<?xml version="1.0" encoding="UTF-8"?>
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<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4JM33</accession>
    <name>W4JM33_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CoA-transferase family III</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_461388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553114.1">
        <property type="nucleotide sequence ID" value="XM_009554819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JM33"/>
    <dbReference type="STRING" id="747525.W4JM33"/>
    <dbReference type="GeneID" id="20677163"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_461388"/>
    <dbReference type="eggNOG" id="KOG3957">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033975_2_0_1"/>
    <dbReference type="InParanoid" id="W4JM33"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050483">
        <property type="entry name" value="CoA-transferase_III_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207:SF3">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW74612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="50005" checksum="C470BE5B62B97484" modified="2014-03-19" version="1">MLSRSAQYRASFRTFQGFPSSLRKLTIVPPDTPDNLPLTGIRVLELGQLIAGPFAGQLLGHFGAEVIKVEPPVTGDPLRIWRELDVDGTSPWFRSLGRNKKSVTIDMRKEEGRALVKKLALQSDVVIENFKPGTLEKWGLGPEDLRPLSPSLIFTRVSGYGQTGPWSTRPGYASVCEAESGFRYINGFPDPKTGALAGPPVRPNISLGDSVAGLHAAFGTVLALFARRVKQDNGLARGSTVDVSILESMLNLMEGIIPEYDRKGKVRGPSGSSITGIVPTNAYPCLPSPSTPTTPAYVIIGANADSMYERLMVTIGRSDLIGPDYKRNNHRVDRQEEIEHTISDWTKKRHAEEVLETLKKIGVPVGRVVNVKDIVEGEQIKARGSIEDVWVGKGKQEEGGDGWTVKMPMVAPVLEGCDAKTRWAGPDLGQHNREVLVDRLGLSEEEMERLVEQGIIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMJ9</accession>
    <name>W4JMJ9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Serine protease S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_153222</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553243.1">
        <property type="nucleotide sequence ID" value="XM_009554948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JMJ9"/>
    <dbReference type="FunCoup" id="W4JMJ9">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JMJ9"/>
    <dbReference type="GeneID" id="20667425"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_153222"/>
    <dbReference type="eggNOG" id="KOG1153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_1_4_1"/>
    <dbReference type="InParanoid" id="W4JMJ9"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844849" evidence="7">
        <location>
            <begin position="21"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="9">
        <location>
            <begin position="57"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="169"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW74758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="500" mass="52574" checksum="69469795FC662F13" modified="2014-03-19" version="1">MSPILSVSLAALSLAAVAAAKPLSTNPNYVPRHGSPFSYAPLLVAEHEAPHGIVNNSYIVMFKQGLHPQAMDNHLNFLQMAHAEDPLMGDESGLRHAYDGHVKGYAGWFSEGVLERIRQMPEVDFIERDQIVRTQDTQRSAPWGLARISHRPKLGFGTFTKYEYEPSGGEGVDVYVIDTGINTKHAEFEGRAAWGKTIPLNDVDDDNNGHGTHCAGTIASQKYGVAKAANVIAVKVLGSNGSGTMSDVVAGVDFAAKAATAKAVAAAAEVKATGSTKHKGSVANMSLGGGKSRALDTAVNGAVDTGLHFAVAAGNDNRDACSYSPAAAEKAVTVGASTLGDERAYFSNFGPCVDVFGPGLNILSTWIGSEHAINTISGTSMASPHVAGLLAYLLSIYPSATFNPSVSSLIPDELNSARPFSGSFSRLYEMAYDCVPGWAAGFLPPPRLVQVISGEGSNEFKTLSPAQLKAALVALASRDLLKEIPSDTVNLLIFNNATTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4JN53</accession>
    <name>W4JN53_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_442796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553446.1">
        <property type="nucleotide sequence ID" value="XM_009555151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JN53"/>
    <dbReference type="GeneID" id="20675487"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_442796"/>
    <dbReference type="HOGENOM" id="CLU_1323639_0_0_1"/>
    <dbReference type="InParanoid" id="W4JN53"/>
    <dbReference type="OrthoDB" id="2884925at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="36"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW74992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="231" mass="26371" checksum="A4011EBE60169F60" modified="2014-03-19" version="1" fragment="single">MAEESDDSTREEVFMESTNALWTLERKVQWNALAPISKLPQEVLLQIFSYHRYGIPRHSFFPTWISITHVCRLFRSISLNCPSLWNNIVLSSSEWTQVMLARAGMVPLEIDTRSLNFQEHTQRQNLCIVLSHLLRIRILSLIGVPAISRDVLAALIAHPAPLLESFTHSTEKEEFTMILPDDIFQGGQVPRLKELSLIGCNFSWTSPLFRDSLTSLSLRCGNEMALPSMFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNP5</accession>
    <name>W4JNP5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_331191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552608.1">
        <property type="nucleotide sequence ID" value="XM_009554313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNP5"/>
    <dbReference type="GeneID" id="20671637"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_331191"/>
    <dbReference type="eggNOG" id="ENOG502SJRZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044614_3_3_1"/>
    <dbReference type="InParanoid" id="W4JNP5"/>
    <dbReference type="OrthoDB" id="3346544at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="291" mass="31899" checksum="51CC35F50D7C9BF3" modified="2014-03-19" version="1">MTQHDISLGKATVISTALEAVLYGFSLMMFIETLWVLLRRARKDISVPMVSAAAMLFTFSTIHIGINIYYSIQGLVHNVYPIIDQNSSELPFILKLVIYWSQTITGDAIIIYRCYVVWQSFYVILLPITMLCGVGVTGAISVWAYATSSPATLGWMLAFYILTLSANLLYTSLLSFGIWRANRTIQKADVYSAFSLIPIIFVIIDAGAIYTIALLASLLCLVNDQNGVLITLDLAVPIISITFYMVIVRVGMPKTSGVMGADGTGTTAFTTVLEPGRDDGINRMADAQFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JP51</accession>
    <name>W4JP51_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_437092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552734.1">
        <property type="nucleotide sequence ID" value="XM_009554439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JP51"/>
    <dbReference type="GeneID" id="20674929"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_437092"/>
    <dbReference type="HOGENOM" id="CLU_2904453_0_0_1"/>
    <dbReference type="InParanoid" id="W4JP51"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW75303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="62" mass="7393" checksum="3D16C2F75EC69C91" modified="2014-03-19" version="1">MVVCRRRMQFLSEYLRIVFMQASCCHINGASFRFILCVPVDRENDNQRQGDSSWRRHLALKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPA4</accession>
    <name>W4JPA4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nab2 type CCCH zinc finger 4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_431107</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553378.1">
        <property type="nucleotide sequence ID" value="XM_009555083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPA4"/>
    <dbReference type="STRING" id="747525.W4JPA4"/>
    <dbReference type="GeneID" id="20674507"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_431107"/>
    <dbReference type="eggNOG" id="KOG3702">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031482_0_0_1"/>
    <dbReference type="InParanoid" id="W4JPA4"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.40">
        <property type="entry name" value="Nuclear abundant poly(A) RNA-bind protein 2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040366">
        <property type="entry name" value="Nab2/ZC3H14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043094">
        <property type="entry name" value="Nab2/ZC3H14_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049017">
        <property type="entry name" value="Nab2_Znf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738:SF29">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21803">
        <property type="entry name" value="Nab2-zf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nab2 type CCCH zinc finger 4" evidence="10">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="81"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="308"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="580"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW74915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="622" mass="65442" checksum="10D476E8848A1698" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPD0</accession>
    <name>W4JPD0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_247322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553228.1">
        <property type="nucleotide sequence ID" value="XM_009554933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPD0"/>
    <dbReference type="STRING" id="747525.W4JPD0"/>
    <dbReference type="GeneID" id="20669166"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_247322"/>
    <dbReference type="HOGENOM" id="CLU_047592_8_0_1"/>
    <dbReference type="InParanoid" id="W4JPD0"/>
    <dbReference type="OrthoDB" id="2367075at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW74741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13372" checksum="6DEC26D8EDA6D987" modified="2014-03-19" version="1" fragment="single">INIDDIESRDFDAFLSILYPTDFDEPDVCTVEGWASVLHLANMWSFNSIRRLAITRLTGLASPVDKLVYGNKYAVGEWLVPAYVSLCQRQEVLSFEEGRRLSSDDIILIMTIRESIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPD4</accession>
    <name>W4JPD4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxyanthranilate 3,4-dioxygenase</fullName>
            <ecNumber evidence="9">1.13.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">3-hydroxyanthranilate oxygenase</fullName>
            <shortName evidence="9">3-HAO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">3-hydroxyanthranilic acid dioxygenase</fullName>
            <shortName evidence="9">HAD</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Biosynthesis of nicotinic acid protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BNA1</name>
        <name evidence="10" type="ORF">HETIRDRAFT_330547</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:17953"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:77612"/>
            <dbReference type="EC" id="1.13.11.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 3-HAO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.6" evidence="9"/>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552755.1">
        <property type="nucleotide sequence ID" value="XM_009554460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPD4"/>
    <dbReference type="STRING" id="747525.W4JPD4"/>
    <dbReference type="GeneID" id="20671587"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_330547"/>
    <dbReference type="eggNOG" id="KOG3995">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095765_0_0_1"/>
    <dbReference type="InParanoid" id="W4JPD4"/>
    <dbReference type="OrthoDB" id="204928at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000334">
        <property type="term" value="F:3-hydroxyanthranilate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06123">
        <property type="entry name" value="cupin_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000131">
        <property type="entry name" value="3-hydroxyanthranilate 3,4-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00825">
        <property type="entry name" value="3_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010329">
        <property type="entry name" value="3hydroanth_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03037">
        <property type="entry name" value="anthran_nbaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497:SF3">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06052">
        <property type="entry name" value="3-HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW75324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="174" mass="19639" checksum="EB2C04F6F14A4B7E" modified="2014-03-19" version="1">MPLAPPLNLPLWLRTHGELLKPPVNNFCLYAGADYVVMAVGGPNERRDYHVNETEEWFYQYRGAMLLRVVDGDAFEDIHIAEGEMFLLPANTPHNPVRFADTIGLVIERVRPADATDRLRWYCREPAHAAPTIIREDAFHVTDLGTQLKPLIERWIADPALRRCPACGVVAPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQB5</accession>
    <name>W4JQB5_HETIT</name>
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        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_436740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="747525.W4JQB5"/>
    <dbReference type="GeneID" id="20674908"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_436740"/>
    <dbReference type="eggNOG" id="KOG0406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066075_0_0_1"/>
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    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="244" mass="26628" checksum="A643157CE2B2AE7D" modified="2014-03-19" version="1">MAAAQAAPITFYTAKVCPFAQRVELAFAEAGAQVNRYFIDLQAKPDWYAPKVNPASKVPAVAYGGPVVPADQPSPESTKIVESLVLLEFVADLYPNAQLLPSSPVDRSRARYFIDVVSNKVVPGFFSMIVKAEGHDALLRGLEEIQSLLPSEGGFAVGEKWSIADAALTPFLGSADLFLRNDMGKYPAGEGPKVHAEIFRGARFARLQKYFADVTVRESWQKTFFPDHIIEKASKALARPAPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQH6</accession>
    <name>W4JQH6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_162576</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552058.1">
        <property type="nucleotide sequence ID" value="XM_009553763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQH6"/>
    <dbReference type="GeneID" id="20667782"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_162576"/>
    <dbReference type="HOGENOM" id="CLU_1219821_0_0_1"/>
    <dbReference type="InParanoid" id="W4JQH6"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW75807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="227" mass="26025" checksum="41A837ED243BD2F8" modified="2014-03-19" version="1">MLMAAICPLPACQGRTFISDTALEQHMRSSRLQHPFCESCDRKFVNVPAFAQHLQAIHSPQYNCCAKTFHSNESLKQHQTTASSHPECSWCDERFINEEERDNHEVARHRLVQCRVCRDCVVRLHELDDHYADSDQHDRCSFCQRGFSDREELFAVSGVSSALTLVQLKMPSIYGKVIQMYSAKSAMNRSYLKNRSNFIMIKRSLSTRVVEYVTSGSKIIRSSVSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQK4</accession>
    <name>W4JQK4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_38032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551847.1">
        <property type="nucleotide sequence ID" value="XM_009553552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQK4"/>
    <dbReference type="STRING" id="747525.W4JQK4"/>
    <dbReference type="GeneID" id="20672013"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_38032"/>
    <dbReference type="eggNOG" id="KOG3968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012358_11_2_1"/>
    <dbReference type="InParanoid" id="W4JQK4"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050287">
        <property type="entry name" value="MTA/SAH_deaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794:SF11">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794">
        <property type="entry name" value="AMINOHYDROLASE SSNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="68"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW75837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="503" mass="53660" checksum="AD21F615791D8A71" modified="2014-03-19" version="1">MGAITLLQNGLLATFTNADGPTATPAARRADVLIDTDRIVQVAAANSIDAAALSPPAAQVIDCSNKWIAPGFVDTHRHLWMSVVEGHEDWTLAEYLAKLSWTTASVVDADDVYIGELAGALQALHGGTTTVVDHFHCANSPEHIKKAIEAATESGLRCMLCMARQSVPSSIDPLRFDNDSAISDMQVSMLESLAQIDAGKLTRDGRVTLGLAYDVLGLNPVEDKRIVTLARSLNITPITAHFVGGPQAPAYGNKAHVWNNAGLLDGDIIFSHANGFTHRGGDENEWALLKNSGASIASTPEDELGMGHGGPVTYEAVRRGVKVGLGIDCKSIVSADMFPAMHSVLQWERGRIHALHAHTSPPKAVKYNAYSCASVFRLATLGGAEAAHAADRIGSIEPGKLADIVLYDADSINLAGCTDPFKGIVIHATAQDVDLVMVNGTIVKKNGRLLPVVTSRGAEEWPKIAARLKTRIAGIQKRLAGTDLHARYDTVAKILHYDFADEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQM9</accession>
    <name>W4JQM9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_436821</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552107.1">
        <property type="nucleotide sequence ID" value="XM_009553812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQM9"/>
    <dbReference type="STRING" id="747525.W4JQM9"/>
    <dbReference type="GeneID" id="20674910"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_436821"/>
    <dbReference type="eggNOG" id="KOG2590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008575_0_0_1"/>
    <dbReference type="InParanoid" id="W4JQM9"/>
    <dbReference type="OrthoDB" id="340227at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF132">
        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="748"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="468"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="551"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="855"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="551"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="866"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW75867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="911" mass="99148" checksum="D546EBF7540F22BB" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4JR38</accession>
    <name>W4JR38_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">GST10</name>
        <name evidence="2" type="ORF">HETIRDRAFT_126057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552234.1">
        <property type="nucleotide sequence ID" value="XM_009553939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JR38"/>
    <dbReference type="STRING" id="747525.W4JR38"/>
    <dbReference type="GeneID" id="20666926"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_126057"/>
    <dbReference type="eggNOG" id="KOG0406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_9_1_1"/>
    <dbReference type="InParanoid" id="W4JR38"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="1">
        <location>
            <begin position="122"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="278" mass="31408" checksum="8E4BA47763D93083" modified="2014-03-19" version="1">MSVASDSGKQYHLECTGLALDTVKKHSAKEDITLFGSCFCPFVQRVWVSFEFLSIPYQVNEADPYKKPRDLLEVSPKGLVPGLKFNTCNPPRALNESTVIMEDLEDLSARTASSTLLPPLTDPYARALVRLQADHVNRALVPTFYRFLQAQDTATQIETSKKLHATLEELVSLLERADRETEAGSGLWKEGGTLNWTDVMANHVWLFRTINVLKHYRAFDLPVGPRFAAWLHRIFEHPAFKSTCSTEQLYLDSYERYAYNRPNTSQVANAINSGQPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRA1</accession>
    <name>W4JRA1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Nonmuscle myosin heavy chain b</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_423094</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552817.1">
        <property type="nucleotide sequence ID" value="XM_009554522.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="W4JRA1">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JRA1"/>
    <dbReference type="GeneID" id="20673868"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_423094"/>
    <dbReference type="eggNOG" id="KOG0161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000192_5_3_1"/>
    <dbReference type="InParanoid" id="W4JRA1"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01377">
        <property type="entry name" value="MYSc_class_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000002">
        <property type="entry name" value="Myosin heavy chain 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.270.10">
        <property type="entry name" value="Myosin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="12">
        <location>
            <begin position="25"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="11">
        <location>
            <begin position="78"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="8">
        <location>
            <begin position="707"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1637"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1974"/>
            <end position="1994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2329"/>
            <end position="2354"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="900"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1739"/>
            <end position="1773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1677"/>
            <end position="1691"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="171"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW75396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2354" mass="270056" checksum="EBBFACAE2F61B077" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRC1</accession>
    <name>W4JRC1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Winged helix DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_66473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551892.1">
        <property type="nucleotide sequence ID" value="XM_009553597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRC1"/>
    <dbReference type="FunCoup" id="W4JRC1">
        <property type="interactions" value="249"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JRC1"/>
    <dbReference type="GeneID" id="20678779"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_66473"/>
    <dbReference type="eggNOG" id="KOG3341">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070147_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRC1"/>
    <dbReference type="OrthoDB" id="283883at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016689">
        <property type="entry name" value="ESCRT-2_cplx_Snf8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806">
        <property type="entry name" value="EAP30 SUBUNIT OF ELL COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806:SF0">
        <property type="entry name" value="VACUOLAR-SORTING PROTEIN SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="28105" checksum="BF1213BD93B0C401" modified="2014-03-19" version="1">MHRLGGVGLAAFDRQQQSQRSFAALSTTLSQSQLDNLHTQLAQFRAALTHFATHRRADIQRDPRFRHAFQQMCATIGVDPLAGPRRGGWWEEALGLGDWQSELGVQIVDVCVSTRERNGGIIEMGELVRLVSRLRGVDGGAVSEEDVVRSIKSLQPLGAGYEVIDFGDGRKMVRSVVKELDEAQMVVLALAQEHGGRVDEDLLVLTQGWTPERAKATLRNMLLRDGTCWVDDQDGPDGMGRSYWVPSAMHWDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRF3</accession>
    <name>W4JRF3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_162813</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552268.1">
        <property type="nucleotide sequence ID" value="XM_009553973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRF3"/>
    <dbReference type="ESTHER" id="9homo-w4jrf3">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="20667795"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_162813"/>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_10_7_1"/>
    <dbReference type="InParanoid" id="W4JRF3"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005150312" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="30"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="42"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="276"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW76044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="523" mass="55589" checksum="493E9DF81C3CBBE4" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4JS66</accession>
    <name>W4JS66_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_389387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551300.1">
        <property type="nucleotide sequence ID" value="XM_009553005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JS66"/>
    <dbReference type="GeneID" id="20672408"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_389387"/>
    <dbReference type="eggNOG" id="ENOG502RXJG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056749_0_0_1"/>
    <dbReference type="InParanoid" id="W4JS66"/>
    <dbReference type="OrthoDB" id="2106152at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40470">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G15850)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40470:SF1">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G15850)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="28086" checksum="4C89CFFC71799A4D" modified="2014-03-19" version="1" fragment="single">MTRPIKETFDAQGFVIIPNLVPSDLRVELEQASENVISKTRSGAWQHRRVVGKQFPPYGNDGVDSWGVQHVMHPDLGEPAFANWYSSHKLREAVKELLGCSDDDLQMELFNLLINPESHEFALRWHRDDVKATASEEEEREALAVWHHGIQWNTALYEDSCLFVVPESHKSPRTNEQRSQSSTPDPPVDPLTMPNAIRVTLQPGETVFYNNNILHCATYNSQAKRATLHASMGDTRGGAARARNILQHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSA7</accession>
    <name>W4JSA7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_441944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551251.1">
        <property type="nucleotide sequence ID" value="XM_009552956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSA7"/>
    <dbReference type="GeneID" id="20675400"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_441944"/>
    <dbReference type="HOGENOM" id="CLU_2073466_0_0_1"/>
    <dbReference type="InParanoid" id="W4JSA7"/>
    <dbReference type="OrthoDB" id="10576005at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="118" mass="13008" checksum="E3EEE2D3CE2AB8B4" modified="2014-03-19" version="1">MLKFSDNTVEGRKTLMADLTLKQKELERQATRQSDQILALIERDQQQFRTAIDARLAKFTSVIQTVYPAITSSAPASIQMITDAHVADVSAARSDQYSDALFEATVATGSGVRINDLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSC6</accession>
    <name>W4JSC6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_411859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551368.1">
        <property type="nucleotide sequence ID" value="XM_009553073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSC6"/>
    <dbReference type="GeneID" id="20672975"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_411859"/>
    <dbReference type="HOGENOM" id="CLU_2292065_0_0_1"/>
    <dbReference type="InParanoid" id="W4JSC6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="101" mass="11843" checksum="FC2B16FC12AB7D11" modified="2014-03-19" version="1">MSVSQLWSYHAIQCPAHTLRRLKAVNCRHTLQMDENAQKCPRLGPVLEPKVRMHILVSHHWLAHIDLGKSWQIEAVRVFAMALRWRQSEMWRLSSNNCMAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSM5</accession>
    <name>W4JSM5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_429907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551361.1">
        <property type="nucleotide sequence ID" value="XM_009553066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSM5"/>
    <dbReference type="STRING" id="747525.W4JSM5"/>
    <dbReference type="GeneID" id="20674393"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_429907"/>
    <dbReference type="HOGENOM" id="CLU_1094416_0_0_1"/>
    <dbReference type="InParanoid" id="W4JSM5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844940" evidence="2">
        <location>
            <begin position="22"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW76459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="254" mass="28721" checksum="E95A1B637366E48A" modified="2014-03-19" version="1">MIFLLLQMASIINLTINYSDSTFVNESTQMTPTPKSSVTEEQFSLSDKEQAAYEAGMDDEATTRLQEEEDRYRDEIMEELKYQERLRQYTEEEAAHPTPSPPHSPSPPPLICEGNKGIIFLDRELYLSTPVTYLMGLIEGSPSTEFVLGPTWPEIQRALEILEEERAFVQHAQSALQMREGTLIARINAGSEGGIREAFGRYRTALDKYQRCRLAPNTVGPCPTNDKPPKDIRQHLGQFAHTSRTHHGHTGVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSN9</accession>
    <name>W4JSN9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_389594</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551447.1">
        <property type="nucleotide sequence ID" value="XM_009553152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSN9"/>
    <dbReference type="STRING" id="747525.W4JSN9"/>
    <dbReference type="GeneID" id="20672419"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_389594"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="InParanoid" id="W4JSN9"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032787">
        <property type="term" value="P:monocarboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000173">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier protein] reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050259">
        <property type="entry name" value="SDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879:SF2">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW76558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="252" mass="26778" checksum="3F86C88813D22688" modified="2014-03-19" version="1" fragment="single">MSKLTSPGTYTPTILQGKLALITGATGGIGQATTRLLASRGVSIAVHYFSSQAKADALVSEILANNPSIKAAAFQADLGDYDAVRRMHKQIVETLGSPDILYCNAAATGTIVGIKGKIQDVTVEEFEKVWRSNTASAFLLSQLCLPFMVEQAWGRVIFCSSIAAATGGVIGPHYASSKSALHGIMHWIANQYCRTGVTCNAVAPALITNTEMFKAPTTAHLDLIPMGRFGQPEEIAAVVELLVTNSYMTNKV</sequence>
</entry>
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            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="GeneID" id="20674921"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_436918"/>
    <dbReference type="HOGENOM" id="CLU_442827_0_0_1"/>
    <dbReference type="InParanoid" id="W4JT84"/>
    <dbReference type="OrthoDB" id="3270378at2759"/>
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        <location>
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            <end position="29"/>
        </location>
    </feature>
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        <location>
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            <end position="225"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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            <begin position="1"/>
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        </location>
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        </location>
    </feature>
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            <end position="565"/>
        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="617" mass="66599" checksum="5408C7736E03862F" modified="2014-03-19" version="1"> </sequence>
</entry>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
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                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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    <dbReference type="InParanoid" id="W4JTR4"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="54" mass="5862" checksum="EB24145ED4BBAEFC" modified="2014-03-19" version="1" fragment="single">VKCGPSAAKCPLVGYGWLSRDRPCLVIVGIFGTYLALFSVSSKLPKYLSQTLAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
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            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
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                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
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            </authorList>
            <dbReference type="PubMed" id="22463738"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="162" mass="16528" checksum="8A6341A78FEB0F15" modified="2014-03-19" version="1" fragment="single">SLVECQSADIVVQSLAGESSVGRPPYYMIAYEVNGLATVSPAGSDPARLSWTVDHRAGSDVILSLVDSAGNSGGVAPATYSITDGSSSCLPSVPAAWPLINANTTKDLDTCQSLGLVMAGGVPPYTVSIVQLGGSVRNVTLGSQDNAYTWINQAAPNSDLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4JU55</accession>
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    <protein>
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    <reference evidence="2 3" key="1">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
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                <person name="Henrissat B."/>
                <person name="Hietala A."/>
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                <person name="Hoffmeister D."/>
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                <person name="Kohler A."/>
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                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009552339.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_388630"/>
    <dbReference type="HOGENOM" id="CLU_2049972_0_0_1"/>
    <dbReference type="InParanoid" id="W4JU55"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="120" mass="13181" checksum="EA2C20DFC2D76057" modified="2014-03-19" version="1">MAIWRGWRRSGVVCSATPGRGLRDWTFHLARARRPAACSLALTAHFPTHTRAGACLWPTHSTPTSPTTHPPPSSAFAAPSPLPPPPLRSHIPPTPSALRPQRHLLSTRGHRHPRAQERHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUK6</accession>
    <name>W4JUK6_HETIT</name>
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        <recommendedName>
            <fullName evidence="4">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_446239</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009552401.1"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JUK6"/>
    <dbReference type="GeneID" id="20675679"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_446239"/>
    <dbReference type="eggNOG" id="KOG0272">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_255861_0_0_1"/>
    <dbReference type="InParanoid" id="W4JUK6"/>
    <dbReference type="OrthoDB" id="163438at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050349">
        <property type="entry name" value="WD_LIS1/nudF_dynein_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44129">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="375"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="834"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="870"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="913"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="956"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="999"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1042"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
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            <end position="1126"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1128"/>
            <end position="1160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW77154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1284" mass="140697" checksum="F47F31990C4CFD58" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4JV80</accession>
    <name>W4JV80_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BAH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_105477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550897.1">
        <property type="nucleotide sequence ID" value="XM_009552602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JV80"/>
    <dbReference type="GeneID" id="20666069"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_105477"/>
    <dbReference type="HOGENOM" id="CLU_030738_0_0_1"/>
    <dbReference type="InParanoid" id="W4JV80"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="2">
        <location>
            <begin position="128"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW77384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="463" mass="50770" checksum="EA25976C555C110B" modified="2014-03-19" version="1">MDGGEEEEGNRWSPRVLWTEDCGHASCLIGPRFCDPAHPLPRPLCPQHHDNPAVAIAVAVARQQHIPHHPRSLASPKMPRAKPRLTRKKKSKAKQAARADPELAALPTDAEWESLTKKKYCDVGSPPFRLRVGTDVLILGQGMSTTSSHFTHELWVGRILELARRRPLARPVDDPGVWAKVQWYYSGADVANDTDIDPANILASCGRYERLRADESDYDYVAHTSFNGPAKVVEYHEEDIAQPPIADGEFYVRRAYSRFSKRATVTKTQRPGPPAPPACNTVYDPDDARPMHFCPKPACRRWFHRDCLEHTAAHSVHVSVESHAFNLLRSDPDSDAPFPLPPPPPPPPPPPPHASSPSRAPPPWTLAALPAKLREAAAQQMLKGVPPYGLVGNAQPIAAARRLVYACLRARTPAELRAAATALDGWMERMDCTDVEGLLADADGGGPGLYFVALFCPLCGGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JV89</accession>
    <name>W4JV89_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_327258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
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            <taxon>Heterobasidion annosum species complex</taxon>
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                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549675.1">
        <property type="nucleotide sequence ID" value="XM_009551380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWJ4"/>
    <dbReference type="FunCoup" id="W4JWJ4">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JWJ4"/>
    <dbReference type="GeneID" id="20678801"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_67203"/>
    <dbReference type="eggNOG" id="KOG2536">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072692_0_0_1"/>
    <dbReference type="InParanoid" id="W4JWJ4"/>
    <dbReference type="OrthoDB" id="278212at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF1">
        <property type="entry name" value="COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="30471" checksum="9F5BA1D30C6E88AD" modified="2014-03-19" version="1">MSALRSLRQLTASSSRTLSTRSLLSTSARSRLPAFALSRTAAVAQPAVRAFSMSMRRLGEGSSDLALSQKLAEELQYEKEASTDAEPDFLKDFRQSGIWTIEDVVGNDEVTIHRKFGNEDIRLVFSIADIQNPEESELEQEESEGESSEDELSTSYPLRCSFSISKPGISGALTIDAMCQEGTFLVDNISFYKDSKLATELTAEADWKRRGLYIGPQFDTLDVAVQDEFDKFLQERGINESLAFFVPEYAEHKEQKEYVRWLQNVKTFIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXF6</accession>
    <name>W4JXF6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_454177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550142.1">
        <property type="nucleotide sequence ID" value="XM_009551847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXF6"/>
    <dbReference type="GeneID" id="20676473"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_454177"/>
    <dbReference type="HOGENOM" id="CLU_045014_0_1_1"/>
    <dbReference type="InParanoid" id="W4JXF6"/>
    <dbReference type="OrthoDB" id="3466517at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="29666" checksum="48AFBB26E4806D45" modified="2014-03-19" version="1">MFPFAAAHRLRLVAVNQRDYRNSTPLSEEDLALLRSEDDDRRTEYFRRISEDGKEEGEIVLVGWPSGNTVVRPLFAYAYEAPEDLKDALEPYMRAYGLYDVPRRLCGFPDIAGFFRPFPDNSELPPAQQLASFETWMSGYYSHPYVMSRDLKCLMQQLQMNVALGKPPTLCTMTPEDKMAVMDPAAVQDHEMFINSMPHDVYLRGILGKCVTGAWDLADSYDEKAKGEVTRAMITTSSRANHFIHWDEPEKVASVFANFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXL3</accession>
    <name>W4JXL3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_453924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549832.1">
        <property type="nucleotide sequence ID" value="XM_009551537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXL3"/>
    <dbReference type="GeneID" id="20676449"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_453924"/>
    <dbReference type="eggNOG" id="ENOG502R79C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_649007_0_0_1"/>
    <dbReference type="InParanoid" id="W4JXL3"/>
    <dbReference type="OrthoDB" id="3181669at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="14"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="423" mass="48841" checksum="179B8D4953A61F0B" modified="2014-03-19" version="1">MQLKRHHSSLNDIIPDDILVSIFHAIVNREFADQAQASDWERQRHQFLCTMDLIQITHVCRRWRYVSVNDPRLWSHILWKRPKWSAEMLLRCKGLPITIDQTIDNHPSIADMREILSHLPRTRALRLSGRQNVCRAFDKELSQPAPMLQSATLIGLEKAYYFWDDESSIVPSNLFAGNAPYLRRLVISRYTLSWKAPIISGLRHLEVRMDNPYPYRTISDYRDRMIPLTSTNDILDALEQAHELQTLILAFTLPYIPDNKPLRSIDRIIRMPRLSQLILQGYMRDCADFAGHLAIHPNARLQYHCLYAGNGEDSSDLALRLLQPCHASITSKPMDVFYAHHELRFFDLKAVERMSQSPTFDLMLDQGPLRGPDSETRNACLLAALQILRSQFVRRAEEHIPAIHVPRPLNSVILSTYSTPAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXY7</accession>
    <name>W4JXY7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polysaccharide lyase family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_149208</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550372.1">
        <property type="nucleotide sequence ID" value="XM_009552077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXY7"/>
    <dbReference type="STRING" id="747525.W4JXY7"/>
    <dbReference type="GeneID" id="20667329"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_149208"/>
    <dbReference type="eggNOG" id="ENOG502S66G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021894_1_0_1"/>
    <dbReference type="InParanoid" id="W4JXY7"/>
    <dbReference type="OrthoDB" id="1637350at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="van Diepen L.T."/>
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                <person name="Hietala A."/>
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                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
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                <person name="Yakovlev I."/>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
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</entry>
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                <person name="Cullen D."/>
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                <person name="Yakovlev I."/>
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    <dbReference type="InParanoid" id="W4JYU7"/>
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    </dbReference>
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            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="66" mass="7035" checksum="909E385B6D8E09DE" modified="2014-03-19" version="1">MYDLSSADFPSNGPSGSLRHSLGSTMLNQHQSLAIPAGHQLSMHPVVTPIRLVTSLLGTRPEGRLV</sequence>
</entry>
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    <accession>W4JYY0</accession>
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                <person name="Broberg A."/>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
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                <person name="Grimwood J."/>
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                <person name="Hietala A."/>
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                <person name="Kues U."/>
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                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="270" mass="29696" checksum="3F749B20D2F22D7E" modified="2014-03-19" version="1">MSSDESPYLSSADDTLIDERTLLPSYLRSPTVSEAGDFKAILRNEDTPMLSARGQEYRREEAERRYQAQVDADAAEEAAAAQTPGSPVIDISTSSSSSPSPPPLIREANEGVVFPDRETYLTTPVVYMMGLIEGTPNTEFVLGPTRPEIQRALEILEEERSFNLQDSFHPAGDPTPSTKYHMPTTAVVSRASSLASNGAPLCPMPGTYPTRTDRERDVYRFAQVSPRYHIIPARLGLIRSSTRTRPPLPFTEYDSSKSDTVPVVLCPRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYY1</accession>
    <name>W4JYY1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dihydrolipoyllysine-residue succinyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HETIRDRAFT_411257</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="5"/>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550088.1">
        <property type="nucleotide sequence ID" value="XM_009551793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYY1"/>
    <dbReference type="FunCoup" id="W4JYY1">
        <property type="interactions" value="505"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JYY1"/>
    <dbReference type="GeneID" id="20672938"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_411257"/>
    <dbReference type="eggNOG" id="KOG0559">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_0_0_1"/>
    <dbReference type="InParanoid" id="W4JYY1"/>
    <dbReference type="OrthoDB" id="5391403at2759"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000006">
        <property type="entry name" value="Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004309">
        <property type="entry name" value="PRK05704.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="14">
        <location>
            <begin position="51"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="126"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETW78086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="447" mass="48246" checksum="C3726DF7CA2E7A02" modified="2014-03-19" version="1">MLSKRVIALARGRAVLSRSATVSPIALSRGWDIAAPHTRRSKFHTTNLLQAETVKVPQMAESISEGTLKSWLKKVGESVEADEEVATIETDKIDVSVNAPAAGKITEFLANEEDTVSVGQDLFRFEPGAAGDAPIDPTPSPSSSESPKDLPKETKDAAEPADQQLNKQTPPPPPPSGGVQGGVPTEGQKKDSKKELKETSKPSKEQKASPPQVAGSRNETRVKMSRMRLRIAERLKESQNAAASLTTFNEIDMSSLMEMRKKYKDEVLDAHGVKLGFMSAFAHASCLALKEIPAANASIEGDEIVYRDYVDLSVAVATPKGLVTPVLRNAEGMSFVDIEREIASLGKKARDGKLTLEDMAGGSFTISNGGVFGSLYGTPIINLPQAAVLGMHAIKERPVVVNGQIVVRPIMVVALTYDHRLLDGREAVTFLVKVKEYIEDPRKMLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZC9</accession>
    <name>W4JZC9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_453384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549112.1">
        <property type="nucleotide sequence ID" value="XM_009550817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZC9"/>
    <dbReference type="STRING" id="747525.W4JZC9"/>
    <dbReference type="GeneID" id="20676374"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_453384"/>
    <dbReference type="eggNOG" id="KOG4305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1042282_0_0_1"/>
    <dbReference type="InParanoid" id="W4JZC9"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CNH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW78809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="267" mass="31025" checksum="67C35B46AEF50C4A" modified="2014-03-19" version="1">MRRVLHLKNVTQCAMLEEVSVFLVMANKVDRLIDALVRLRHELFKALFACHIDMMVASPPPSTADKCIVRPAADQPWWKPWLHQEAKPHSETRYRSTVYFLTLHPVARKIKEKAEVETLGSRLGLRPPRSEWFREDRSFYVPSSFSERLSSPSASLSSPYRRARPNRVAIPRFDDSRCDELAKRCSSRRPMGMSRVRKNEYLLCYNEFGLYTDRHGCPIRSRDTIQWEVTAQRVAWHPPYVHLSDLEVTEIRHIDTGGLCDQNSCGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZG2</accession>
    <name>W4JZG2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycolate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">GOX2</name>
        <name evidence="7" type="ORF">HETIRDRAFT_50111</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548766.1">
        <property type="nucleotide sequence ID" value="XM_009550471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZG2"/>
    <dbReference type="STRING" id="747525.W4JZG2"/>
    <dbReference type="GeneID" id="20678131"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_50111"/>
    <dbReference type="eggNOG" id="KOG0538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020639_0_1_1"/>
    <dbReference type="InParanoid" id="W4JZG2"/>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF75">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_4G07050)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="3"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="315"/>
            <end position="319"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="338"/>
            <end position="339"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW78968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="404" mass="44177" checksum="0AB7F2ADF0FA390B" modified="2014-03-19" version="1">MSTVPSFSVHPDELTESTKETLNNRAYFYANSNAGLGWYGQGKQAFYRWRIVPRMLVDTNTRDLTTELFRHRIPAPILFAPIGINKLYSPEGDLVPAKITGELGLPYCLSTASSQPIEAVAAANDRGASGPNGGNAKSPRFFQLYIGHDDEIAHLTDRIAQTVSLLERAWKSGFDVCMLTVDTWQLGWRPTDIAIANYTFGQHVGNEVGTSDAVFMKKHGEEMKTDSGKWIDSAVWHGKAHTWDKMPWLIREWKRISSGRPFVIKGIQSVEDAVGCEGIVVTNHAGRQVDGAVGSLEVLPEIVHAVGGKMKIIFDSGIRTGADVFKALALGAHAVQVGRLYVWGMSHEGEAGCRHVIKSLLADLDITMTVAGYASVTEDVRRNRKALRYTASGTAPGSGEHAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4K023</accession>
    <name>W4K023_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_120969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550419.1">
        <property type="nucleotide sequence ID" value="XM_009552124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K023"/>
    <dbReference type="STRING" id="747525.W4K023"/>
    <dbReference type="GeneID" id="20666727"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_120969"/>
    <dbReference type="HOGENOM" id="CLU_003921_7_2_1"/>
    <dbReference type="InParanoid" id="W4K023"/>
    <dbReference type="OrthoDB" id="3252634at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="416"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW78451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="54322" checksum="A4037C6E377ACA6C" modified="2014-03-19" version="1">MATPSMPARGDRTAPTFDPHQPRELRRYFADLDFHFVRSAVEDEQERKKHACRFLDVDTCELWESLTTFTDATKTFKEFCEEVYRLYPGSEEERKWSVSDMDKLVGETSRVGILSLSELGDYHRRFLAITVFLLSKARISVAEQGRAFARGFQPELWARISQRLQLKFPDHFPDDPYNLQDIHDAARFVLHSTTSAYSTTSTDISRAAPAAPPTNTIKAEDLATMFERLTDTFVKAIAAQGTSRPADRPSRQPGQGGDNCMFCGSPEHFMRACPEVNEYIRIGKCKRNIEGKVVLSSGAFVPREITGSNLKDRVDEWHRRNPGQLATGQMMFTVNAAPTHPMTIASRHDSPSLLDVTPTYQLTDVQRIASLERELFALRTRGARAREMAQTGRSAPTPSPAPERRARTETPEPEPRPTTPTQRPPPVPAKDDAPIHPYAKAQDATYAPPHERNIGAPAKIPSAKKDAPAYKTTAPIYDEKVAAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0L6</accession>
    <name>W4K0L6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_453761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
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                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548188.1">
        <property type="nucleotide sequence ID" value="XM_009549893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2P0"/>
    <dbReference type="GeneID" id="20668698"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_226882"/>
    <dbReference type="eggNOG" id="ENOG502SDII">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022145_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2P0"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055647">
        <property type="entry name" value="DUF7223"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23865">
        <property type="entry name" value="DUF7223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7223" evidence="1">
        <location>
            <begin position="290"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="501" mass="51990" checksum="EBC6D765275C2EF1" modified="2014-03-19" version="1" fragment="single">AANDWTVPCVQGECSYDVSSPDGNNAATLKIWGASDAISDITPAAGWQILSCDPNGMDQDIRLVCMHDDASCDHLLEGGAENTIVRLPETCAQMPFARVARQWTSQDQSLPAAVRRNIVSRASSPVVHALALDTNFADIDPSKKGNVSFAAQGSTIGGVGGNSTAQRRDLRHLSVFSRKHRRGFLSSIADAFKGALDSIKQLDEFNKTLDKQLPPIDLNKSANLFNASVSCPASATSPAAFDASVSVDVTGEVHAVVDLGVAAAGTIIPPKVSHFALIAGASSMSFFCLNANVGGTLDVSANANGHLDTGAIKLFEVAIPGFDIPGIFTIGPSFKLNAQATGDLNIDLDMKVDIAYTVNNAQLTFPPDQGASKGVFKPADSNLALSASSNLNGDATLEAHIIPTVDVGISFLGSVASATVFLDLDASATLDITGAAQASAGASTKTGKAASASAQGCVDLSSGFDVNAGAQGSFFGLFDKSTQVTLFSKDFELFQVRTRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3K9</accession>
    <name>W4K3K9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_409881</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547179.1">
        <property type="nucleotide sequence ID" value="XM_009548884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3K9"/>
    <dbReference type="FunCoup" id="W4K3K9">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K3K9"/>
    <dbReference type="GeneID" id="20672815"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_409881"/>
    <dbReference type="eggNOG" id="KOG1102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005350_11_2_1"/>
    <dbReference type="InParanoid" id="W4K3K9"/>
    <dbReference type="OrthoDB" id="295078at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000003">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF22">
        <property type="entry name" value="RAB-GAP TBC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="74"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="357"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW80423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="443" mass="50738" checksum="797616DAAD8928C1" modified="2014-03-19" version="1">MDLSRNHDGGSQRRSVDGKLTLQDEYNRSHGGDSQEDNGGTGGIDWEFWGSVVSDYQTFASEHGDRLARAIEKGVPDSLRGMMWQLMSTSKDVELENTYIKLLKESSPHEKAITRDLGRTFPHHTFFTDNQGIGQENLFNVLKAYSIYDPQVGYCQGLPFIVAVLLLNMPDEEAFCLLVRLMHSYDLRGHFLPEMPKLQLHLFDRLIEEMLPVLHIHFLRQGVKSSMFCSQWFLTLFSYRFPHEIVNRIFDNVLASGIESIFGFSLALLQKNEDKLLELKFDQIVAFLNTQIVDTYLEPSPEGSDLKPTYRVDDFVQDAMSTKITSFMLDSYTHEYNEMIRVREAHILEMEALRTSNRNLSLQVNTLETSLAQLNQEHVDLLQNELVAARLRHEELEGELVRYKLLYAESVHKNEDALSGHRISLSVSRPASGSTSLRSLISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3M3</accession>
    <name>W4K3M3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_101565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547164.1">
        <property type="nucleotide sequence ID" value="XM_009548869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3M3"/>
    <dbReference type="GeneID" id="20665780"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_101565"/>
    <dbReference type="HOGENOM" id="CLU_1396491_0_0_1"/>
    <dbReference type="InParanoid" id="W4K3M3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="195" mass="20828" checksum="80F128BDD0B48644" modified="2014-03-19" version="1">MSFSSRAARTASNVHWERRAPVSHSVALPGGSSGRRVKATGVSAIEEMPVKVRVQPEQEGSSAKVWAALALMVNKPSNTQQTARETQAVTLRGGRAACIARRAPRRTSDTSTDLLGAQPARSPALDQPNTPRLSTPSLQTQPNTPTDRTQAKPARLAAPARCASPDRRSRASEIPVQARTPVPRVVCARAGIWSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W4K462</accession>
    <name>W4K462_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peroxisome targeting sequence binding protein Pex5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_46561</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxisomal targeting signal receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546951.1">
        <property type="nucleotide sequence ID" value="XM_009548656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K462"/>
    <dbReference type="STRING" id="747525.W4K462"/>
    <dbReference type="GeneID" id="20677196"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_46561"/>
    <dbReference type="eggNOG" id="KOG1125">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013516_1_0_1"/>
    <dbReference type="InParanoid" id="W4K462"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005052">
        <property type="term" value="F:peroxisome matrix targeting signal-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024111">
        <property type="entry name" value="PEX5/PEX5L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130:SF0">
        <property type="entry name" value="GH08708P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="129"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="163"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="197"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW80602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="287" mass="31552" checksum="B391FCEA6FD69B5F" modified="2014-03-19" version="1" fragment="single">DVVQSVLQLEAAVQRDPTNARAWFELGVKQQENEREQQAIQALRRALELEPSHLPSWLALAISSTNEGDRMGTFASVKEWVDRNERFQAAVAAHRASVGGVGAGADTFSGLIDCLIAMARSEANGSVDADIQIALAVLLNTNEEYAKAQDCFRAALAVRPEDWLLYNRVGATMANSGQAEEAILYYNRALELNPAYIRARFNLGISYINLQRYEEAASHILDALVLQDSDRVGGPDDGRGIMSSALWDSLKTTSLHMQRADLAALCERQDLEGTSRGAHNLEHEQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4P5</accession>
    <name>W4K4P5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_320071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547484.1">
        <property type="nucleotide sequence ID" value="XM_009549189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4P5"/>
    <dbReference type="GeneID" id="20670641"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_320071"/>
    <dbReference type="HOGENOM" id="CLU_2298311_0_0_1"/>
    <dbReference type="InParanoid" id="W4K4P5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW80778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="101" mass="11353" checksum="B45DBBE2CD0665FB" modified="2014-03-19" version="1" fragment="single">EHIAKVSAQFILHLFVCPNTPLSLSATSILPCDWTTSLYIPFIRNNSELPSPLPFFTFFSDPRPAFPLLRAPWATVYLSEHLSLPSRLSMITLIPIMPSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4U0</accession>
    <name>W4K4U0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_101538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547135.1">
        <property type="nucleotide sequence ID" value="XM_009548840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4U0"/>
    <dbReference type="GeneID" id="20665778"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_101538"/>
    <dbReference type="HOGENOM" id="CLU_771741_0_0_1"/>
    <dbReference type="InParanoid" id="W4K4U0"/>
    <dbReference type="OrthoDB" id="3245210at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="372" mass="43664" checksum="644B9AE46C205E5D" modified="2014-03-19" version="1">MSKRQPGQTKNALEIQLEAEEKKVDEIILRERKKAHLEWETFRRSARREMLEIEARSKERLADEKSKIEEVKIQAMGRLSKVREGMDEALRQLKSKHEREWSRLTGLETDIILEREREMAATRTSMEEEAEEKIKDVKAKLKAENDDLYGRFREAVQRARAEGRKRKTDAVEKWFEEKNKRERNLMLAKQTEAEASGQHREWERRAKSKGDESKRRTAEKGRKICLAGQQVSARAARAWAEYEDRWRRIKSDSRETVLLFRDIPWPTLKTPYHAFDIEIDGIHEFVLSPNHSPGMSVEARLNSELMRWDEDVFAYVLSRVAEADKTQVELGAILVRTFLEELLERSETTPSMGTDKRSSRNSLSSMSPYRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4Z6</accession>
    <name>W4K4Z6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_410065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547510.1">
        <property type="nucleotide sequence ID" value="XM_009549215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4Z6"/>
    <dbReference type="GeneID" id="20672832"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_410065"/>
    <dbReference type="HOGENOM" id="CLU_2671357_0_0_1"/>
    <dbReference type="InParanoid" id="W4K4Z6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="75" mass="8487" checksum="BEDDB0FC4FC5866F" modified="2014-03-19" version="1">MYGRARTAERRRRAGGGMVSVGWRREWGWRPRRQGSMKQEWKPGGETGATRMGATGARREKRGLKLKRSDAANAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5W0</accession>
    <name>W4K5W0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1168-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_123173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547449.1">
        <property type="nucleotide sequence ID" value="XM_009549154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5W0"/>
    <dbReference type="STRING" id="747525.W4K5W0"/>
    <dbReference type="GeneID" id="20666814"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_123173"/>
    <dbReference type="eggNOG" id="KOG4055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079129_1_0_1"/>
    <dbReference type="InParanoid" id="W4K5W0"/>
    <dbReference type="OrthoDB" id="10067079at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009548">
        <property type="entry name" value="Prkrip1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507:SF0">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06658">
        <property type="entry name" value="DUF1168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="24817" checksum="E29C0B8F3CAFDA6A" modified="2014-03-19" version="1">MSTHSPSPHPSSTEPSSRHASTPVEKQRSQLERLLKDPSKPAYIPAPPKEKTIRPAREMMKNVQGSSAGAGSGEFHVYKAGRRREYERLKAMEDQARKEQEESEFEARKRQREEEADAKTAKNRAKRQKKKERAKGKGPEKDGAEDAGGSAIGPAQATTSGAPLKKRRLVNGKELVFKRPGEESDDDEEVGPEPVSKAEFGPYDSENALAPIAIDVPRIIIHEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6J5</accession>
    <name>W4K6J5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Terpene synthase</fullName>
            <ecNumber evidence="6">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_51706</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the terpene synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="6"/>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545852.1">
        <property type="nucleotide sequence ID" value="XM_009547557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6J5"/>
    <dbReference type="STRING" id="747525.W4K6J5"/>
    <dbReference type="GeneID" id="20678191"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_51706"/>
    <dbReference type="eggNOG" id="ENOG502SJ0F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042538_5_0_1"/>
    <dbReference type="InParanoid" id="W4K6J5"/>
    <dbReference type="OrthoDB" id="6486656at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW81359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="332" mass="38044" checksum="03BA4A7E36D6EF38" modified="2014-03-19" version="1">MTTKIYLPDTLAHWRWPRRINPHYLEVKEEAAAWIASFRVFSPKAQRAFDLCDFKHLRTGCDFMNLLLLFDESSDVEDAAGVQLQADIIMDALCNPHKPRPAGEWIGGEIFRQFWERAIKTASPQSQKRLVNAFSTYTQSMVQQAADRSHAHIRDIDSYLQVRRETVATKPAFALFELDMDLPDEVVNHPVIQDLSIWAADMHSLANDMLSYNVEQARGDDAHNIVTVVMNQLKTDIAGAMTWVEGYHKELERKFNEHFDKVPQWGGLIDVQVALYMNGVGNSVRANDQWCFESKRYFGNKGLEILKTRYVTLMPKTHADEMGPQVIDDSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6J7</accession>
    <name>W4K6J7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleolar protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_426853</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-25S rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRM RBM34 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546075.1">
        <property type="nucleotide sequence ID" value="XM_009547780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6J7"/>
    <dbReference type="FunCoup" id="W4K6J7">
        <property type="interactions" value="304"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K6J7"/>
    <dbReference type="GeneID" id="20674156"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_426853"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018832_0_0_1"/>
    <dbReference type="InParanoid" id="W4K6J7"/>
    <dbReference type="OrthoDB" id="442677at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF25">
        <property type="entry name" value="RNA-BINDING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="297"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="481"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="332"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW81428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="538" mass="59393" checksum="6AA434D949F863E2" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6T8</accession>
    <name>W4K6T8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Carnitine O-acetyltransferase, mitochondrial</fullName>
            <ecNumber evidence="16">2.3.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HETIRDRAFT_156259</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-carnitine + acetyl-CoA = O-acetyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:21136"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57589"/>
            <dbReference type="EC" id="2.3.1.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.7" evidence="16"/>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546185.1">
        <property type="nucleotide sequence ID" value="XM_009547890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6T8"/>
    <dbReference type="STRING" id="747525.W4K6T8"/>
    <dbReference type="GeneID" id="20667630"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_156259"/>
    <dbReference type="eggNOG" id="KOG3717">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013513_5_1_1"/>
    <dbReference type="InParanoid" id="W4K6T8"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000007">
        <property type="entry name" value="Carnitine O-acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF103">
        <property type="entry name" value="CARNITINE O-ACETYL-TRANSFERASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="20">
        <location>
            <begin position="42"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ETW81552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="624" mass="69597" checksum="FCACD6308AA424F7" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7N8</accession>
    <name>W4K7N8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peroxidase</fullName>
            <ecNumber evidence="13">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">hpox3</name>
        <name evidence="16" type="ORF">HETIRDRAFT_169836</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 Fe(II)-[cytochrome c] + H2O2 + 2 H(+) = 2 Fe(III)-[cytochrome c] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.11.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="13"/>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547769.1">
        <property type="nucleotide sequence ID" value="XM_009549474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7N8"/>
    <dbReference type="SMR" id="W4K7N8"/>
    <dbReference type="STRING" id="747525.W4K7N8"/>
    <dbReference type="GeneID" id="20668241"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_169836"/>
    <dbReference type="eggNOG" id="ENOG502QR1E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036959_1_1_1"/>
    <dbReference type="InParanoid" id="W4K7N8"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004130">
        <property type="term" value="F:cytochrome-c peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00691">
        <property type="entry name" value="ascorbate_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000009">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000005">
        <property type="entry name" value="Cytochrome c peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF58">
        <property type="entry name" value="CYTOCHROME C PEROXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 13 16" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="15">
        <location>
            <begin position="179"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETW81091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="376" mass="41489" checksum="F3589D981D446A87" modified="2014-03-19" version="1">MQSSFASSFRASARRAAFSSARVPKGPLRSAYRKYSTEPEAPKSKTGLYAGIGALAVGGGLALYFYSSSPDTLATSAKSGAQAVKVAANFVPTKEDYQKVYNKIAEAIDEAGDYDDGSFGPVFLRLAWHSSGTYDKNTSTGGSNYATMRFEPEALHGANNGLNIARGLMEKVKQEFPWISYGDLWTLGGVAAIQEMSGPKIPWRAGRIDGFPKDVTPDGRLPDASQGQNHLRDIFYRMGFNDQEIVALSGAHALGRAHTDRSGFEGPWTFSPTTLTNEFYKLLLDEKWIWRKWAGPKQLTDKTTGTLMMLPTDYALVQDKTFKKYVKAYAADQDLFFKDFSAVVSRLFELGIPDSQFTSTEKWTLKSLDEQKEASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7Y2</accession>
    <name>W4K7Y2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_440109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546449.1">
        <property type="nucleotide sequence ID" value="XM_009548154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7Y2"/>
    <dbReference type="STRING" id="747525.W4K7Y2"/>
    <dbReference type="GeneID" id="20675228"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_440109"/>
    <dbReference type="eggNOG" id="ENOG502SJSA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062080_0_0_1"/>
    <dbReference type="InParanoid" id="W4K7Y2"/>
    <dbReference type="OrthoDB" id="2596855at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW81854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="354" mass="38203" checksum="F3B04EEE4EBDB0CF" modified="2014-03-19" version="1">MASTNEAASGSTSSARALDVQEMHPPAGPLPSKRGEIGYQEQIHGRPQVQEAEAASIPERHPADTPLAGNLSSPSSSPSSSVPTITTSSAPASAPSTPLNDSSSTHSMGKRSIASLLKPKNVPTYGGVRLTTILILLFQLSLLGGTIAGWVLAVKLLGRRQSQQPGDDPNGQINGGTTSIFVYVAFGITVLAQLLFLERRIFRVRAERYGYLHPGEMLPTSLRRVSARRSTAMGIAPWHRPPLPTYAAALAQSGVGTGDVEDSAIAPPPPPAYGHTRGSRLLLAGFLRTSLRAQARELEVDRRSRMSERSDRPVSFMSRDEEWEERRDAERALQVEEALARLEEGHQERPVRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4K884</accession>
    <name>W4K884_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_427210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546587.1">
        <property type="nucleotide sequence ID" value="XM_009548292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K884"/>
    <dbReference type="STRING" id="747525.W4K884"/>
    <dbReference type="GeneID" id="20674185"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_427210"/>
    <dbReference type="eggNOG" id="KOG2651">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016581_1_2_1"/>
    <dbReference type="InParanoid" id="W4K884"/>
    <dbReference type="OrthoDB" id="10258156at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052220">
        <property type="entry name" value="METTL25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496">
        <property type="entry name" value="CGI-41 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496:SF0">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="167"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW82003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="577" mass="63502" checksum="2EBDBAA85BA88063" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8F8</accession>
    <name>W4K8F8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_318294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546649.1">
        <property type="nucleotide sequence ID" value="XM_009548354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8F8"/>
    <dbReference type="GeneID" id="20670493"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_318294"/>
    <dbReference type="HOGENOM" id="CLU_2740327_0_0_1"/>
    <dbReference type="InParanoid" id="W4K8F8"/>
    <dbReference type="OrthoDB" id="10039611at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="71" mass="8266" checksum="DC979E1D6C4915F3" modified="2014-03-19" version="1">MNATSTRMAKNNKLVHGVDGKVMKEKVWMVDAMFNRHPQSLYFSDGKHPDHAAGVFKGMIRILEEHWYYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8W2</accession>
    <name>W4K8W2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_317685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546742.1">
        <property type="nucleotide sequence ID" value="XM_009548447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8W2"/>
    <dbReference type="GeneID" id="20670439"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_317685"/>
    <dbReference type="HOGENOM" id="CLU_1610918_0_0_1"/>
    <dbReference type="InParanoid" id="W4K8W2"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="19152" checksum="17D7441D0C239218" modified="2014-03-19" version="1">MKEWCLSNMTGMASCGLLEPAFLYVLKHIDPLIIPRPAGRRFSKHLAHELQQKWNAIVDEYIAMGEFPRSSFEVERAAKIGYGNGALIRVCGAEECDNVEEGADDKFRFRQCSGCHIVSSFPVVVRSRPTEDWFRVVQSVCCSSKCQRSAWPTHKKACGSDTHLQQMLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9I7</accession>
    <name>W4K9I7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_154744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546597.1">
        <property type="nucleotide sequence ID" value="XM_009548302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9I7"/>
    <dbReference type="STRING" id="747525.W4K9I7"/>
    <dbReference type="GeneID" id="20667520"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_154744"/>
    <dbReference type="eggNOG" id="KOG1216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1372668_0_0_1"/>
    <dbReference type="InParanoid" id="W4K9I7"/>
    <dbReference type="OrthoDB" id="3366093at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005034">
        <property type="term" value="F:osmosensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006972">
        <property type="term" value="P:hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007232">
        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001402">
        <property type="term" value="P:signal transduction involved in filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039295">
        <property type="entry name" value="MSB2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35778">
        <property type="entry name" value="SIGNALING MUCIN HKR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35778:SF1">
        <property type="entry name" value="SIGNALING MUCIN HKR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW82015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="22207" checksum="208F74EDAFAA1600" modified="2014-03-19" version="1">MWLAYIPSSNVSSLASLVSTQKSKFYTGVPDPYATLASHIDPAFSVDTVSVTAGTGSSSGSGSSAASTTGGSSNNSRQDAIIGVVSALGGLTLIILAVLVYRAVKKRRELAHRRLSDPNIPNDPYPDRAGRDFDQDSIGGPRRRSFYFAEDSLRGTSVQPSGVQTQHPAMGEVEYSYRHSPENMRERRPVMPGAISAPILQQSSMNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9J1</accession>
    <name>W4K9J1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Metallo peptidase M3A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_36792</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545785.1">
        <property type="nucleotide sequence ID" value="XM_009547490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9J1"/>
    <dbReference type="STRING" id="747525.W4K9J1"/>
    <dbReference type="GeneID" id="20671829"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_36792"/>
    <dbReference type="eggNOG" id="KOG2089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001805_1_2_1"/>
    <dbReference type="InParanoid" id="W4K9J1"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06455">
        <property type="entry name" value="M3A_TOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000006">
        <property type="entry name" value="Thimet oligopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.40">
        <property type="entry name" value="Endopeptidase. Chain P, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="9">
        <location>
            <begin position="223"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW81741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="681" mass="76856" checksum="2E1FCDEF0D6E1498" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9R6</accession>
    <name>W4K9R6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ICL3</name>
        <name evidence="13" type="ORF">HETIRDRAFT_65122</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545906.1">
        <property type="nucleotide sequence ID" value="XM_009547611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9R6"/>
    <dbReference type="FunCoup" id="W4K9R6">
        <property type="interactions" value="80"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K9R6"/>
    <dbReference type="GeneID" id="20678718"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_65122"/>
    <dbReference type="eggNOG" id="KOG1260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019214_2_2_1"/>
    <dbReference type="InParanoid" id="W4K9R6"/>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
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    </dbReference>
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    </dbReference>
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            <position position="204"/>
        </location>
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            <begin position="95"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="12">
        <location>
            <position position="166"/>
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        <ligand>
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        </ligand>
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        <location>
            <begin position="205"/>
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        </location>
        <ligand>
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        <ligand>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW81791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="541" mass="59578" checksum="38A85A094FE93E02" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAN0</accession>
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        <recommendedName>
            <fullName evidence="1">MACPF domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">HETIRDRAFT_38497</name>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Bondarzewiaceae</taxon>
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            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="ETW82882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="494" mass="54069" checksum="CDAF9B233A906355" modified="2014-03-19" version="1">MDYPIVTDVLHGSVRAKVSAAIAGDTLNEVNNDPVQRNKLIDNNNLLSGVVMTSGSPVISSRKLIVRPNILNTTIDNSAGIRTTMVEAEFSNTLMESNYTSVAVKVSTPYVAASVEYSESSSYKSTETEKTVYSSSCYRFPQGRIDFNRPSSGSGSILLSTEFTSEINTALAKSSLLEKREALYNIFNEYGHVFRNQVTIGGALSAHTQETFSRSENEDEVRQDIKVALEGELKGWGGSASAGHGNSKTTITTKQGKNLVTDYIVTGGDYTKIQNTADWISTTNRPEYWRVIEVTSVIPVVDLLPEQQSSQVKRLLKPLLGKWVDVEKMQGFDHLPIAIYRPISIPSGWFWLGHTADSKKALLVKPTLPAKGGRNFVLSGGHANSSGVSTQLLADHAHYQFLATYFGQLDFTQNPGASIRALRPDIALLGQYTMYGDSIDTAVYVTRPISPLSPEDEGLDLQSTVRVKLVGMGNVPKPKWVLRKDAVLFDSGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAT5</accession>
    <name>W4KAT5_HETIT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_107099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545242.1">
        <property type="nucleotide sequence ID" value="XM_009546947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAT5"/>
    <dbReference type="GeneID" id="20666213"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_107099"/>
    <dbReference type="HOGENOM" id="CLU_834346_0_0_1"/>
    <dbReference type="InParanoid" id="W4KAT5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="333" mass="35531" checksum="D6C77CA693040316" modified="2014-03-19" version="1">MARERQGSVGSQERSLDWTGRSNRGRQTRSDLPGTPPAAIEFEIRFAGKETDSKGPAPSMTHRPNRAPSCPGSSRGPTFSPPPTNTILQAGVRAAVAAVTAAAAAAAASSRTRPVHAPPETPDTPPPATRRGDRAAQKRPRAQCSDGADCDQPGLKQLELSVRPACVRQRSLVARTPDLRRPPVGPVTSRNHVHVPAAFLSLFSNESQIPVFERPSPRASTPGLMNPPCNTTPAHPTRKRILSPDAVFGSQSPPSNYQPPRRPTSDEPAAAIAPLAWAALLATASRCYDPSRLRSQTCQPPIDIPAHNVDHPTDPETRVSLARSLFPPSARVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAV1</accession>
    <name>W4KAV1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_315577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009546866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAV1"/>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_315577"/>
    <dbReference type="eggNOG" id="KOG4650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043418_1_0_1"/>
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    <dbReference type="OrthoDB" id="67965at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF17">
        <property type="entry name" value="STEROID 5-ALPHA REDUCTASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="288" mass="31831" checksum="3593DBC687FF53CC" modified="2014-03-19" version="1">MNAFSRLLPVLGSAYGLQAALAAIFVPQANEKFYDLGGALGFISTTLISLYYPAVRAQIRYGSAAAPFPSLSSFAPRQLLLSAALGIWSVRLGSFLVQRAIKAGGDSRFDEVKHQPTKFTAFWMAQATWVFLVGLPVYLVNTLPSNLHPALGLRDYAAIGIYGSSLLFEVIADRQKSAWRHEKENKQHDDKFITIGLWSLSRHPNYVGEVGIWTGIWMLAIGSLQTAYFPAYTFALAAISPITTYTLLRNVSGVPPLEASGDKKFGQDPKWKEYKKTVPVFWPWGGYD</sequence>
</entry>
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    <accession>W4KAY0</accession>
    <name>W4KAY0_HETIT</name>
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        <recommendedName>
            <fullName evidence="6">CWH43-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_242467</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545284.1">
        <property type="nucleotide sequence ID" value="XM_009546989.1"/>
    </dbReference>
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        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KAY0"/>
    <dbReference type="GeneID" id="20668929"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_242467"/>
    <dbReference type="eggNOG" id="ENOG502RZQS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050573_3_0_1"/>
    <dbReference type="InParanoid" id="W4KAY0"/>
    <dbReference type="OrthoDB" id="10032492at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="6">
        <location>
            <begin position="2"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW82992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="210" mass="23307" checksum="ADED372172B25207" modified="2014-03-19" version="1" fragment="single">YVWIPAFGAFIWFGTLLSMILTWVGQGRPIYISEDGTIPYISDIGADILKPLFVAGCSVTAISFILSLSIERLLRHTGRLHPDMRKREFAFSYLAILGSVIGGAGLILLSCFDTKRHPSLHRVFLLVFIVGVALSALFTIAEYRWLSKGCADERELKIAYSAKAIIALILIALAIAFGITLFKNTNVGGILEWIIAFGYTFYLLSFVYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4KB62</accession>
    <name>W4KB62_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
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                <person name="Velez H."/>
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                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009547030.1"/>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_458595"/>
    <dbReference type="eggNOG" id="ENOG502SPA1">
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    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="150"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW83038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="590" mass="66400" checksum="665D377569DFBE0E" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4KB90</accession>
    <name>W4KB90_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aspartic peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_107207</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545352.1">
        <property type="nucleotide sequence ID" value="XM_009547057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KB90"/>
    <dbReference type="GeneID" id="20666223"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_107207"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037038_0_0_1"/>
    <dbReference type="InParanoid" id="W4KB90"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF74">
        <property type="entry name" value="AGR407CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845276" evidence="2">
        <location>
            <begin position="21"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="74"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW83068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="585" mass="61583" checksum="CB949F3531474FFD" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBY1</accession>
    <name>W4KBY1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_107006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545149.1">
        <property type="nucleotide sequence ID" value="XM_009546854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBY1"/>
    <dbReference type="GeneID" id="20666205"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_107006"/>
    <dbReference type="HOGENOM" id="CLU_132759_0_0_1"/>
    <dbReference type="InParanoid" id="W4KBY1"/>
    <dbReference type="OrthoDB" id="3235294at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="126" mass="13712" checksum="1956ED503B97861B" modified="2014-03-19" version="1">MNSVHTLYPDDDSEKEVYVQANGLSFSGVGDRHLTGGVGGYGHYSPFAEIRPSAEIKHELFVLGKFSRAQRDETLKLARDVVLVKASRTNNCCVWTRDLLGAMLGARLISQAAFAAVDAGRWSPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KC88</accession>
    <name>W4KC88_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_450975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545640.1">
        <property type="nucleotide sequence ID" value="XM_009547345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KC88"/>
    <dbReference type="GeneID" id="20676097"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_450975"/>
    <dbReference type="HOGENOM" id="CLU_1669593_0_0_1"/>
    <dbReference type="InParanoid" id="W4KC88"/>
    <dbReference type="OrthoDB" id="3070163at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW83383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="158" mass="18397" checksum="A564D3A8A556DD8E" modified="2014-03-19" version="1">MLMKAQELWDKVFPRHLHVLAAKDEAVFNLVMQRIYVWRRNFATEAIKRVKAFWESDPLYADAEERAAYVQWAVPETKGGQVPAIYEDVDKSDITNPAEHMLLQWSIGNFKAPKGEEEQFSQKYWGVKTVEYVESLGKATEKSWKKIFLKTAVTTARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4KD15</accession>
    <name>W4KD15_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_449399</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543500.1">
        <property type="nucleotide sequence ID" value="XM_009545205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KD15"/>
    <dbReference type="FunCoup" id="W4KD15">
        <property type="interactions" value="844"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Lactamase_B_6"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="314"/>
            <end position="462"/>
        </location>
    </feature>
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        <location>
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            <end position="173"/>
        </location>
    </feature>
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        </location>
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        <location>
            <begin position="660"/>
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        </location>
    </feature>
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            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
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        <location>
            <begin position="535"/>
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        </location>
    </feature>
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            <begin position="565"/>
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        </location>
    </feature>
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        <location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW83747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="932" mass="102554" checksum="C689200560C8FCA2" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDN5</accession>
    <name>W4KDN5_HETIT</name>
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        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_123637</name>
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            <taxon>Agaricomycotina</taxon>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <text evidence="2">Belongs to the fl(2)d family.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="WTAP"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        </location>
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        </location>
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            <end position="235"/>
        </location>
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            <end position="280"/>
        </location>
    </feature>
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            <end position="312"/>
        </location>
    </feature>
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            <end position="336"/>
        </location>
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            <end position="352"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW83908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="352" mass="38676" checksum="D1422BFF8FAF0D3C" modified="2014-03-19" version="1">MDLPSARELELEELLRRRDVQLAELNDEVAHLRQYLSTQPGPSKTDPVSLPPALVSLLLPHINTIADDAHAGSRSSTVTTALTQRAKLLQEENDELYELLKSGETGRLKEEVRGLRRAVDRLEMALRESHLVITSLSDELDKSYDAIQSTGRHHNNTNAHPHLPTRQNFHSAAPAPVPAHPQSTSNGNAKPLPTGPRAHKKPRLSEPQISPANSTAALPRIQTQQTQRQGSAQTRGHSTASPERSPVLPPDHRKASGVKMEVDDDQRTRPRTPPLPPPPAPRDRERDRGRDRDREKDRGRDRNRDRDRERTSRRNGGQGGGGRKGGRTGGGGGGGGGRHDSGDRTLAERMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEE6</accession>
    <name>W4KEE6_HETIT</name>
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        <recommendedName>
            <fullName evidence="3">Amidoligase enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_314822</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545679.1">
        <property type="nucleotide sequence ID" value="XM_009547384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEE6"/>
    <dbReference type="GeneID" id="20670162"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_314822"/>
    <dbReference type="eggNOG" id="ENOG502SUNA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039967_0_0_1"/>
    <dbReference type="InParanoid" id="W4KEE6"/>
    <dbReference type="OrthoDB" id="5291055at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022025">
        <property type="entry name" value="Amidoligase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847:SF1">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12224">
        <property type="entry name" value="Amidoligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW83431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="39771" checksum="2BEBD8B8F9BC2F0D" modified="2014-03-19" version="1">MSGCLPGSAYKFYEEASSSKPRTVFTQSSDGYCFGIEIELTLSPKVQNIHQFHSSLLPGPMEDDGTYPWEQMATALTMLLDRVLWDRGMGRASQRQSYDKWCVTFDDTIQPPRGFSGFEIISPILTTEMDWRVVIETIYAVVDAYFIIQASPSCGTHVHITPGRRTWNVADLRALSKAIVLWDPVIEGLLPEERRIDAPDSWHRSNIHGQLALHLEQFHSDGFDHLFQMIDDIDDRDEIVDFISPDKAWAWNFCHVKEACGTVEFRKPPMALTSSAAVAWIEFTLMFVRAATGMEMGYWEGVGSQNARPSIRALESFVCLGLMPGTIDGKSGLTLFQDLTTSRSGGSAGPCLVAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEH1</accession>
    <name>W4KEH1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Delta-1-pyrroline-5-carboxylate dehydrogenase</fullName>
                <shortName evidence="10">P5C dehydrogenase</shortName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="9">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
                <ecNumber evidence="9">1.2.1.88</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_408379</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="9"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543909.1">
        <property type="nucleotide sequence ID" value="XM_009545614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEH1"/>
    <dbReference type="FunCoup" id="W4KEH1">
        <property type="interactions" value="182"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KEH1"/>
    <dbReference type="GeneID" id="20672679"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_408379"/>
    <dbReference type="eggNOG" id="KOG2455">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_4_1_1"/>
    <dbReference type="InParanoid" id="W4KEH1"/>
    <dbReference type="OrthoDB" id="5322683at2759"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000006">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000005">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 9" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="11">
        <location>
            <begin position="67"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW84213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="547" mass="59306" checksum="84093198C98C3625" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEQ4</accession>
    <name>W4KEQ4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="13">TC-AMP synthase</shortName>
            <ecNumber evidence="3 13">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HETIRDRAFT_458094</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3 13"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543921.1">
        <property type="nucleotide sequence ID" value="XM_009545626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEQ4"/>
    <dbReference type="FunCoup" id="W4KEQ4">
        <property type="interactions" value="240"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KEQ4"/>
    <dbReference type="GeneID" id="20676883"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_458094"/>
    <dbReference type="eggNOG" id="KOG3051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031397_0_0_1"/>
    <dbReference type="InParanoid" id="W4KEQ4"/>
    <dbReference type="OrthoDB" id="412787at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000009">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="32"/>
            <end position="224"/>
        </location>
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        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>L-threonine</name>
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        </ligand>
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    <feature type="binding site" evidence="14">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
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            <position position="81"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>L-threonine</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
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        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
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        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
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    <feature type="binding site" evidence="14">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
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            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
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        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR004930-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETW84229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="399" mass="42624" checksum="D53438EE2C66302D" modified="2014-03-19" version="1">MSVSAHVLRCEPSSISFSADDELPNFDDEVTRASLTAAAHQIKSAQAIGFPTETVYGLGALALDASAAARIFSTKGRPADNPLIVHVSSQRMLRSLLPPTYAPSRSYEVLMKRFWPGALTLLFPSDPSTVPQIVTANHPTVAIRMPSHPVARALIALVDAPIAAPSANSSGKPSPTRAEHVFKDLGSKLSLILDGGSCTVGLESTVVDGLNEDGNIRVLRPGGVTVEDIEGALREEIGEGSKVPRVLVHKRDFQDAAMEATPTTPGMKYRHYSPSVPVTLLYTSTSPPPGTASTTLSDLFASLKTTHAQRPVKVGLLVPSDSRILLQTDEVSGLEFTVFYLGAVSDPAVTAHRLFDGLLTLEERGSDIILVEAILEEKEGLAVMNRVKKAASESQWINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KF19</accession>
    <name>W4KF19_HETIT</name>
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        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_63165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009544991.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_63165"/>
    <dbReference type="eggNOG" id="ENOG502SKAZ">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_046025_5_4_1"/>
    <dbReference type="InParanoid" id="W4KF19"/>
    <dbReference type="OrthoDB" id="3263055at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF6534"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
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            <end position="110"/>
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    </feature>
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        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
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            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
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        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
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            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
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            <begin position="170"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW84447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="311" mass="34276" checksum="89A9AD025C8A563A" modified="2014-03-19" version="1">MASSGAVPSIDATLGATFIGVVVAAVLYGVTCLQTWHYYHTYGSDTWRLKGLVLSVWICDTVHQVLISHTVYTYLVTHYADPQYLSMLVWSLLVEVLFNGFTAFVVQCFFTIRIYNLSHKNIMLTGLVAALVLAQFCVTLVYVGKSLPMKTYEQLDTLKGLSMAVNATTAASDVVIAMSLVSMLHLSRTGFKRSDSVINKLILYTVNTGLLTSIDAICSLASIAALPNTFIYICFFFALGRLYANSLLATLNARKSIRQKVSPDDMSLSGLQSIPRTVDVPGLKKVCLNIFLVIARPNLYDSADKQYRHPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KF22</accession>
    <name>W4KF22_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucocorticoid receptor-like (DNA-binding domain)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_416017</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family.</text>
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        <property type="protein sequence ID" value="ETW84314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009545703.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="W4KF22">
        <property type="interactions" value="206"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KF22"/>
    <dbReference type="GeneID" id="20673284"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_416017"/>
    <dbReference type="eggNOG" id="KOG1741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139869_2_1_1"/>
    <dbReference type="InParanoid" id="W4KF22"/>
    <dbReference type="OrthoDB" id="413436at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1480:FF:000001">
        <property type="entry name" value="30S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_uS14_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006477">
        <property type="entry name" value="PRK08881.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836:SF19">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW84314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11578" checksum="BAC9FCFF688E287C" modified="2014-03-19" version="1">MPNIRILRDMRARQGVSENEIVRRAYLFVARNQSLPPQVRYQAQLQLNTFGRYTRPTTVKNRCSESGRGRGVMSEFKLCRVQFRQKALAGELPGVHKASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFM0</accession>
    <name>W4KFM0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_382109</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544186.1">
        <property type="nucleotide sequence ID" value="XM_009545891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFM0"/>
    <dbReference type="STRING" id="747525.W4KFM0"/>
    <dbReference type="GeneID" id="20672105"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_382109"/>
    <dbReference type="eggNOG" id="ENOG502QVFZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015119_1_0_1"/>
    <dbReference type="InParanoid" id="W4KFM0"/>
    <dbReference type="OrthoDB" id="165352at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="562"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="595"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW84524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="640" mass="71845" checksum="B9DF3680605DD95B" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFT4</accession>
    <name>W4KFT4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_432937</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543640.1">
        <property type="nucleotide sequence ID" value="XM_009545345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFT4"/>
    <dbReference type="STRING" id="747525.W4KFT4"/>
    <dbReference type="GeneID" id="20674641"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_432937"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_490946_0_0_1"/>
    <dbReference type="InParanoid" id="W4KFT4"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="158"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="256"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="370"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="386"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="517"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW83911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="568" mass="61342" checksum="B00D92190AACFAA8" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFU8</accession>
    <name>W4KFU8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_449532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543654.1">
        <property type="nucleotide sequence ID" value="XM_009545359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFU8"/>
    <dbReference type="GeneID" id="20675956"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_449532"/>
    <dbReference type="HOGENOM" id="CLU_1042277_0_0_1"/>
    <dbReference type="InParanoid" id="W4KFU8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="267" mass="29349" checksum="FD9E9273D8B3DDCC" modified="2014-03-19" version="1">MPPKRKAPLEATESERPLTRFRTRSADLASSTELPAPRRTRARGPASPILEVSEPAVKRRRAGARKAESNNITGEISQKDESSHPDETPDVVPVRRGRPRKPSTSEGVPKTKPARPTRIIRSKAQEHSQHEDEHESNDKVVQAPTRRGRPRKAASSVPQSSKPVMVNTVAPEPHEVRSNEYATQSLVPVRRGRPRKAATLASQNSKPSKKLKPDIIPLEPDESHSDTEEHEQSKGLEEPSTALQPSSKVVDEQIAEASSPAIYTSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFV6</accession>
    <name>W4KFV6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_449542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543663.1">
        <property type="nucleotide sequence ID" value="XM_009545368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFV6"/>
    <dbReference type="GeneID" id="20675958"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_449542"/>
    <dbReference type="HOGENOM" id="CLU_1434603_0_0_1"/>
    <dbReference type="InParanoid" id="W4KFV6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="189" mass="20572" checksum="FE53135CFA43447D" modified="2014-03-19" version="1">MSRKRHRTTPAGANDRPATACHPLTNPTKAGNACEGKPLPPPPTVASLAVPTPRHARARIEHGHHDHNHDDDHDDANANANANDECRRSPTTQRRADSFPSDRDNESVGRSQLLDGCYSAPGRPTIGTSCTQRASIGTPLPVVRVRVRLRLRLRLRLPHEKKHGHPSVRRRIASAATDAGGFHAPQLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGW1</accession>
    <name>W4KGW1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_473637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544575.1">
        <property type="nucleotide sequence ID" value="XM_009546280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGW1"/>
    <dbReference type="STRING" id="747525.W4KGW1"/>
    <dbReference type="GeneID" id="20677527"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_473637"/>
    <dbReference type="eggNOG" id="ENOG502R1CZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123996_0_0_1"/>
    <dbReference type="InParanoid" id="W4KGW1"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="33"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW84954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="188" mass="20864" checksum="FEDC04BBF0C7EF46" modified="2014-03-19" version="1">MASIDPPSDRKRPRTELDAELLINHPALYFDDGNVILQCGKTLFRVHRSILLKHSTLFQEMLAPARDTLRDCTSIKVVDDKDDMEALLNTIYDGFTIDASQITIENFPTISGILRLAHKYRVPRLRVAWPSALDKHLARARALTAWRASQPHAEDLIVHPAACAPSTAPITPCSPRSSTTSAAARRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGY7</accession>
    <name>W4KGY7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar ATPase assembly integral membrane protein VMA21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_312422</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544240.1">
        <property type="nucleotide sequence ID" value="XM_009545945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGY7"/>
    <dbReference type="STRING" id="747525.W4KGY7"/>
    <dbReference type="GeneID" id="20669954"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_312422"/>
    <dbReference type="eggNOG" id="ENOG502SBNA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154717_0_0_1"/>
    <dbReference type="InParanoid" id="W4KGY7"/>
    <dbReference type="OrthoDB" id="160405at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019013">
        <property type="entry name" value="Vma21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792:SF3">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09446">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW84590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12210" checksum="9A7B4CC514A65CFF" modified="2014-03-19" version="1">MRGQTAGSTIVDQGVQGGVLIKLIIFSLSLGVIPIGSYFISEKYLWKGKRSSYSVMQSSDDLYAGNATYAAITAIIAANLVLVAYIVLSLIEDRHDQEVLSIVKDKQSRKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4KH04</accession>
    <name>W4KH04_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_381789</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543995.1">
        <property type="nucleotide sequence ID" value="XM_009545700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KH04"/>
    <dbReference type="FunCoup" id="W4KH04">
        <property type="interactions" value="195"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KH04"/>
    <dbReference type="GeneID" id="20672088"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_381789"/>
    <dbReference type="eggNOG" id="KOG3507">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179456_0_1_1"/>
    <dbReference type="InParanoid" id="W4KH04"/>
    <dbReference type="OrthoDB" id="5585087at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.30:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerases II, IV and V subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006591">
        <property type="entry name" value="RNAP_P/RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039747">
        <property type="entry name" value="RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056:SF2">
        <property type="entry name" value="GEO11084P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03604">
        <property type="entry name" value="Zn_ribbon_RPAB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00659">
        <property type="entry name" value="RPOLCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW84311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="62" mass="7062" checksum="2DD7A79D03AA2F3D" modified="2014-03-19" version="1" fragment="single">MNQPGTQNTNGNGTGTGFMPAPRQEMEYLCADCGAKNEIKSREPIRCRECGHRIMYKKRTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHE2</accession>
    <name>W4KHE2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bola-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_17930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543145.1">
        <property type="nucleotide sequence ID" value="XM_009544850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHE2"/>
    <dbReference type="FunCoup" id="W4KHE2">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KHE2"/>
    <dbReference type="GeneID" id="20668552"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_17930"/>
    <dbReference type="eggNOG" id="KOG3348">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109462_0_1_1"/>
    <dbReference type="InParanoid" id="W4KHE2"/>
    <dbReference type="OrthoDB" id="203381at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052275">
        <property type="entry name" value="Mt_Fe-S_assembly_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188:SF1">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW84476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9037" checksum="821B13D36BE0737E" modified="2014-03-19" version="1" fragment="single">RPYSAASSPPPNLDSGEQVIYHKLTERFKPSELLVQDVSGGCGSFYAITIASQAFKGLSIVKQHRLVNDALKKEIEGIHGLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHG1</accession>
    <name>W4KHG1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_312645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544170.1">
        <property type="nucleotide sequence ID" value="XM_009545875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHG1"/>
    <dbReference type="GeneID" id="20669972"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_312645"/>
    <dbReference type="HOGENOM" id="CLU_3032603_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHG1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="55" mass="6357" checksum="C799EB2DF8A35D6E" modified="2014-03-19" version="1">MFHHCHHHHPNSSNCLSHKYGLPVVALTVVVFKCATIYSPYFPPLPSCQYYYSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4KI38</accession>
    <name>W4KI38_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_60879</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541857.1">
        <property type="nucleotide sequence ID" value="XM_009543562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KI38"/>
    <dbReference type="FunCoup" id="W4KI38">
        <property type="interactions" value="267"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KI38"/>
    <dbReference type="GeneID" id="20678526"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_60879"/>
    <dbReference type="eggNOG" id="KOG0542">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037266_1_0_1"/>
    <dbReference type="InParanoid" id="W4KI38"/>
    <dbReference type="OrthoDB" id="448399at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051274">
        <property type="entry name" value="3-5_Exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044">
        <property type="entry name" value="3'-5' EXONUCLEASE ERI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044:SF61">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="4">
        <location>
            <begin position="53"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW85507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="295" mass="33549" checksum="053A633037C92712" modified="2014-03-19" version="1">MFSIIKARPAPLPASFIRSATTNDAPVFVSDSADIPVAAPEPLPPFVHQPFDAFLVLDVEATCLQGTDFQWPNEIIEWPVCLLRWTDKQKNGHASTLETVDEFRSFVRPTWRPKLSEFCTALTGITQEQVDNAPQFPQVAENFSHFLAKNGLIHPDTGERLVRFCWCTDGPFDVRDFVVKQCFISKMQMPHWIRGDVMDVRRVVSHWQFGMAQTKKPLLPRRLSLNIAGQLRALGLAPFQGREHSGIDDARNISRIVTELARRGFRLEPNTHIQPGRRWAWMGRSGQVIEAYCLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJK1</accession>
    <name>W4KJK1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_310571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542114.1">
        <property type="nucleotide sequence ID" value="XM_009543819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJK1"/>
    <dbReference type="GeneID" id="20669788"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_310571"/>
    <dbReference type="HOGENOM" id="CLU_2469363_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJK1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW85241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="88" mass="9827" checksum="A455ABD6C486F8DC" modified="2014-03-19" version="1">MSSWLLFSLYLARSLDFYTLVQLVNFALLVILTLLFVLVLLSANHSGLLGPSRVTTSFQCICCYSPSRKRNSSCASPHQFAPRSRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KK86</accession>
    <name>W4KK86_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_141440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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                <person name="Martin F."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_141440"/>
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            <end position="37"/>
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    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="71" mass="7751" checksum="7EC3CAB53A0DBF17" modified="2014-03-19" version="1">MSLSSSQPIQLASPQPHATMSPIPTSHSPTGIVPPQQSKGIFVTYQPDRRPTPDLEDILSKKKVAQTWGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
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                <person name="Murat C."/>
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                <person name="Rouze P."/>
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                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
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    </reference>
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    <dbReference type="eggNOG" id="ENOG502SKHB">
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    </dbReference>
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    <dbReference type="Pfam" id="PF18759">
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        </location>
    </feature>
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        <location>
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            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="644"/>
        </location>
    </feature>
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        <location>
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            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="980"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="998" mass="114727" checksum="E3C5BEEB8ABAF261" modified="2014-03-19" version="1"> </sequence>
</entry>
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    <accession>W4KKZ3</accession>
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        </submittedName>
    </protein>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009544271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKZ3"/>
    <dbReference type="GeneID" id="20667350"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_150109"/>
    <dbReference type="eggNOG" id="KOG2615">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_54_6_1"/>
    <dbReference type="InParanoid" id="W4KKZ3"/>
    <dbReference type="OrthoDB" id="419616at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="61"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW85736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="527" mass="56921" checksum="17FB90227B1EC6AB" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLF3</accession>
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        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_308501</name>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542682.1">
        <property type="nucleotide sequence ID" value="XM_009544387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLF3"/>
    <dbReference type="FunCoup" id="W4KLF3">
        <property type="interactions" value="172"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KLF3"/>
    <dbReference type="GeneID" id="20669593"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_308501"/>
    <dbReference type="eggNOG" id="KOG4288">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055314_0_0_1"/>
    <dbReference type="InParanoid" id="W4KLF3"/>
    <dbReference type="OrthoDB" id="276721at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF16">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="325" mass="35007" checksum="1098A29797DED643" modified="2014-03-19" version="1">MESLVQKILVVGGNGFIGSAVCKAALSRGFQVTSLSTSGQPFRTPKGHSPAWTSKVDWRVGDALRPETYAHMLPGVSAVVHTLGTLLEDTGYKKALRSGDVGGAVKSFMRSVTGVRGNPLEKGQGKGSYEVLNRDSALTVAEAFMGSKATVELPGPRPFVYISAEDIFRPMISARYVETKREAERGIEQLTAGRPEYRGVYIRPSLVYHPHFRPYTSPVAALLDLSSVVHSKIPRGLPTPSNLLRALSPAFPTGTAPSSPIQTSPLDSVANALTLPPIHVDHVAEAICIAVDNARPDIHGVYGVREMREMIGWSQKGQQPSLRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLH5</accession>
    <name>W4KLH5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_438656</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542970.1">
        <property type="nucleotide sequence ID" value="XM_009544675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLH5"/>
    <dbReference type="STRING" id="747525.W4KLH5"/>
    <dbReference type="GeneID" id="20675061"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_438656"/>
    <dbReference type="eggNOG" id="ENOG502SIK2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035837_0_0_1"/>
    <dbReference type="InParanoid" id="W4KLH5"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF18">
        <property type="entry name" value="HEAT SHOCK PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="166"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW86210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="403" mass="44697" checksum="D14C10BEACAAE475" modified="2014-03-19" version="1">MFAIASDDVEEVRRVLESGEAGPNDQLGPQSALAFTLTNDRLMHKMEIVKELLAYGANPASLHNPEMNPPHSASIFASGSDHGREAGGWPLVVTPPLTTTMDGMNPATRYYISRADAPATRKTSALIHRSIFRPLTRMRYDIVGQDRVFEQLFMHLNEHSRRFSVSPIVFLFCGPSGHGKSLLAHKFGSLLGIPTHTVNMTSLRSTHDLWQSQSYQDMSPQTLSEFLLENEGKRCVVVLDEIEKVQDPKVHYSLLPAFEGRYFLHGPNRLVDMRNVVWLGTSNLGDQYVFEYQSTLSNPTAAMSREEYLDLIGLMRTKVTDQLGGGLIGRCTAVLPFVPFTEEEKIVIATEALLMHQADAELAEGLSAATLENAARKSLARYIPAEGARSLHRAVSAMLLDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLN3</accession>
    <name>W4KLN3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methionine aminopeptidase</fullName>
            <ecNumber evidence="10">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_145807</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="10">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associates with the 60S ribosomal subunit of the 80S translational complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="10"/>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542754.1">
        <property type="nucleotide sequence ID" value="XM_009544459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLN3"/>
    <dbReference type="FunCoup" id="W4KLN3">
        <property type="interactions" value="611"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KLN3"/>
    <dbReference type="GeneID" id="20667102"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_145807"/>
    <dbReference type="eggNOG" id="KOG2738">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_2_1_1"/>
    <dbReference type="InParanoid" id="W4KLN3"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="12">
        <location>
            <begin position="5"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW85956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="379" mass="42135" checksum="060485112709A92A" modified="2014-03-19" version="1">MSAPIVICQSSKCPHGNPPSRLECPTCHKLGIQGSFFCGQDCFKADCESKTHKLVHELATPRQLLLDDPSINKNGTFNPFHGYRFSGSLRPVYPLSPPRTVPEHIPKPDYAEDGIPTSESRRAGQPPRILSTEDQEKMRKVCKLAREVLDIAASHIRPGITTDDIDAVVHQAAIERNAYPSPLNYRHFPKSVCTSVNEAICHGIPDQRRLQEGDIINIDVTLYYDGFHGDLNETYPVGRIDDDSRKLIRVARECLDESIKLCRPGALFRDLGKTIEPIARANGCSVVRTYTGHGINDLFHSSPNVPHYSKNKAIGTMKPGMTFTIEPMINLGSSWDEIHWPDNWTATTSDGKKSAQFEETLLITETGVEILTAGKPRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLP2</accession>
    <name>W4KLP2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_456594</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540632.1">
        <property type="nucleotide sequence ID" value="XM_009542337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLP2"/>
    <dbReference type="FunCoup" id="W4KLP2">
        <property type="interactions" value="410"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KLP2"/>
    <dbReference type="GeneID" id="20676760"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_456594"/>
    <dbReference type="eggNOG" id="KOG3301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089738_0_0_1"/>
    <dbReference type="InParanoid" id="W4KLP2"/>
    <dbReference type="OrthoDB" id="1697570at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000021">
        <property type="entry name" value="40S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003139">
        <property type="entry name" value="PRK04051.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="10">
        <location>
            <begin position="6"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="9">
        <location>
            <begin position="107"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW86629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="193" mass="22376" checksum="5C9F3130EA72278F" modified="2014-03-19" version="1">MPRAPRNHSKTYKVPRRPFESARLDAELKLAGEYGLRNKREIWRIALILSKIRRAARELLKLDDKDPKRLFEGNALIRRLVRIGVLDESRMRLDYVLALKIEDFLERRLQTQVFKSGLAKSIHHARVLIRQRHIRVGKQIVNVPSFVVRLDSQKHIDFALTSPYGGGRPGRVKRKRALAAAKKEEGGDEEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMH8</accession>
    <name>W4KMH8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_100234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543012.1">
        <property type="nucleotide sequence ID" value="XM_009544717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMH8"/>
    <dbReference type="GeneID" id="20665673"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_100234"/>
    <dbReference type="HOGENOM" id="CLU_1806408_0_0_1"/>
    <dbReference type="InParanoid" id="W4KMH8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="143" mass="15260" checksum="CE37BE5F52084D78" modified="2014-03-19" version="1">MRSDIHRSTDTALAHKRKQAARSSACRGACNTIANPFRLRLATLARIGAHNTSDWGHSGRVSSSSAAHLQGPVDVIDARCPLVPRRPPVGCHACVRGLKPGPSANPASRWEPPGGRPRRAPFDESQARGRSEGASAQRRTASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMV6</accession>
    <name>W4KMV6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_431328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540705.1">
        <property type="nucleotide sequence ID" value="XM_009542410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMV6"/>
    <dbReference type="GeneID" id="20674527"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_431328"/>
    <dbReference type="eggNOG" id="ENOG502SNEH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084561_0_0_1"/>
    <dbReference type="InParanoid" id="W4KMV6"/>
    <dbReference type="OrthoDB" id="3363533at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="34"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW86710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="227" mass="25655" checksum="00D7F62C4E5148BA" modified="2014-03-19" version="1">MRRAQTLRHNGRPSLALGADDLGMLRENPDESTEDILRRQLLEKDRENDKLQTQIQSLQVQLAQRPPIETIQALEKEYKNLELILQGTQRENERAMTELERGKTREKMLERELAKLAGENWQACLRRTAYSANLEIAPSSASAFVARSLIAGPPQGSSPKGSQTKHEASPATAEATLAHVEQMRLLILGMQQRLQTREETLTKVIERAEGEGMKFEELRRSMLSAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPQ8</accession>
    <name>W4KPQ8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">MFS sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_153907</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541278.1">
        <property type="nucleotide sequence ID" value="XM_009542983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPQ8"/>
    <dbReference type="GeneID" id="20667460"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_153907"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="InParanoid" id="W4KPQ8"/>
    <dbReference type="OrthoDB" id="648285at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000119">
        <property type="entry name" value="MFS monosaccharide transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF73">
        <property type="entry name" value="METABOLITE TRANSPORT PROTEIN YDL199C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="22"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="473"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW87370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="530" mass="58267" checksum="5671B3EE1FA27B8D" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W4KQP6</accession>
    <name>W4KQP6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_413677</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541274.1">
        <property type="nucleotide sequence ID" value="XM_009542979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KQP6"/>
    <dbReference type="FunCoup" id="W4KQP6">
        <property type="interactions" value="338"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KQP6"/>
    <dbReference type="GeneID" id="20673123"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_413677"/>
    <dbReference type="eggNOG" id="KOG2910">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086201_0_1_1"/>
    <dbReference type="InParanoid" id="W4KQP6"/>
    <dbReference type="OrthoDB" id="441172at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF5">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="164"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW87366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="207" mass="23444" checksum="12B8856566C8C4D4" modified="2014-03-19" version="1">MGGNQSVPRVTAQDRAILDLKLQRDKLKQYQKKIQTILNREHEIAKQQLAAGQKDRALFALRRRKYQESLLVKTDGQLENLEQLVSTIEFSLVEVSVLHGLKQGNEVLREIHKEMNIESVEKLLDETAEARAYEKEIGELLSNSLTLDEEDAVQEELKALQEQAVLEQSHEEDQELPSVPTTEPVSEAEEAGKLDAQQGRERIPIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W4JME7</accession>
    <name>W4JME7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dynamin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_437290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553215.1">
        <property type="nucleotide sequence ID" value="XM_009554920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JME7"/>
    <dbReference type="STRING" id="747525.W4JME7"/>
    <dbReference type="GeneID" id="20674944"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_437290"/>
    <dbReference type="eggNOG" id="KOG0446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008964_4_1_1"/>
    <dbReference type="InParanoid" id="W4JME7"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="55"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="660"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW74727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="754" mass="84356" checksum="44C88D3AA8B7F170" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMJ3</accession>
    <name>W4JMJ3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucosidase II subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HETIRDRAFT_68114</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">TC 32-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
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        <property type="protein sequence ID" value="ETW74753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009554790.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="W4JMJ3">
        <property type="interactions" value="450"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JMJ3"/>
    <dbReference type="GeneID" id="20678847"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_68114"/>
    <dbReference type="eggNOG" id="KOG1066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000631_7_0_1"/>
    <dbReference type="InParanoid" id="W4JMJ3"/>
    <dbReference type="OrthoDB" id="3237269at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090599">
        <property type="term" value="F:alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="GH31_GANC_GANAB_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF54">
        <property type="entry name" value="BCDNA.GH04962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844897" description="Glucosidase II subunit alpha" evidence="11">
        <location>
            <begin position="24"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="13">
        <location>
            <begin position="91"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="12">
        <location>
            <begin position="372"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="14">
        <location>
            <begin position="713"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETW74753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="963" mass="108184" checksum="2D798577A77C9854" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMP3</accession>
    <name>W4JMP3_HETIT</name>
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        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_456322</name>
    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009554966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JMP3"/>
    <dbReference type="GeneID" id="20676731"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_456322"/>
    <dbReference type="eggNOG" id="ENOG502SRA7">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="19"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW74783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="317" mass="35784" checksum="18AD32DD97AFF228" modified="2014-03-19" version="1">MADQSAVLVGLQHLNIETYVNACAITILAYDYLLTLPYEIKYMWTQKWSLIKVLFFLTRYPVFFDTYNSVTIFRLKFAMPFTALLDGSSYLGSPLLKVRLFFAMHRLSAHPPTLKGIIIMRTWAIWGRRKSIGIFLISLFTASLITACVCLALFEKSTRFVPISTLGPLSTGKGCLADRANIDVVGTYASFTVFDTVIVILTVIKGLQLRELHPSHSNLFLTLYRDGMLFYVTLFVIVAVATDLMLLLLGLQRVLYSVLSARILFHIHQAVEPPPMSFAQNDMPMKFAVHRTPRQTRDQESGASCSTDVEMAVFDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMQ2</accession>
    <name>W4JMQ2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">GST6</name>
        <name evidence="4" type="ORF">HETIRDRAFT_164952</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="GST_omega"/>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
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    </dbReference>
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        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GSTRNSFRASEO"/>
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        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="27"/>
            <end position="105"/>
        </location>
    </feature>
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            <begin position="112"/>
            <end position="232"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW74827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="256" mass="29244" checksum="492C471BA9A68861" modified="2014-03-19" version="1">MAIADADLFPHATGEAAKTVAKHTEPQELVFYAGWFCPYAQRGWIALEEKGIPYQYKEINPYHKEKHFLAINPKGLVPAIEYQNKPLYESLIISEFLEDAFPTHEPHLLPADPFARAQARLWIDHISKAVIPAFQRLLQSQEAPKQAAALEELKTALRTLAQNAKGPYFFGEGWSLVDTAIAPWVTRDYIQQEHRGYKREDVSPEWVAYAGKLETRESVVKTRSEKRHYEPIYGRYLRDEAQSEAAKAIRAGRVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNR7</accession>
    <name>W4JNR7_HETIT</name>
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        <recommendedName>
            <fullName evidence="4">Microtubule associated protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">HETIRDRAFT_330826</name>
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        </lineage>
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            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75183.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </feature>
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            <end position="774"/>
        </location>
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            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="671"/>
            <end position="685"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW75183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="793" mass="87119" checksum="28259F188CF58AE5" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNT2</accession>
    <name>W4JNT2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_330662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
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                <person name="Murat C."/>
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                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="20671599"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_330662"/>
    <dbReference type="HOGENOM" id="CLU_1454603_0_0_1"/>
    <dbReference type="InParanoid" id="W4JNT2"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW75217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="186" mass="21374" checksum="E1045B53CD573EB0" modified="2014-03-19" version="1">MHEHGSAARVEVDRKVFGRYHETLRLLVTSRHEGDIEVSIGSLCPQGHVRVGEDFANEDTGIYLDGMLGRHTKLAKRREEIKASLLKNAQGMFGLAALQIEDLIKCRKRKEMQEHLDRPPSTLFAMYDRILSRLDHGGREDARKVLLWLAFSVHKLNLRQLVEVIAVNFDTEDEPCFYPTSRYEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4JP24</accession>
    <name>W4JP24_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_153262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553137.1">
        <property type="nucleotide sequence ID" value="XM_009554842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JP24"/>
    <dbReference type="GeneID" id="20667426"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_153262"/>
    <dbReference type="HOGENOM" id="CLU_765171_0_0_1"/>
    <dbReference type="InParanoid" id="W4JP24"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW74641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="362" mass="39788" checksum="819711C174AD30B2" modified="2014-03-19" version="1">MSPSLVGFQIDPFQDLLIAVFMNTCPGDPGHSSCQVRPLSMTGGKHSSGASESSCTLLGDYEEESIIHINGDLVTILVQGLSVHQVIIVWDWKAAKLKTQLHFTQVLIFDLAFLSDYLLCVLEDRFISGTTKQAALLVYDVKSTTAEIVLHDSNFVAAFLLPDCSDDVDIEHISLQVDLVPQSSSGGLAAISLFGRYTGNGDGPAFRTLDIFVHSSFLVRCSEASYDRRRIIPWSEWGPFNTHAVSTTSSDYIEEQPISLSGLRASARSTSESIVRVYDFDPLRIGRSRGEEEIMISDSCHVPPGTWNKDGISTHLPCLVSEVELPTTLRWWNPKYGMICELGLFSAIDDPSADVGFGWFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JP30</accession>
    <name>W4JP30_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_442522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552743.1">
        <property type="nucleotide sequence ID" value="XM_009554448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JP30"/>
    <dbReference type="GeneID" id="20675461"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_442522"/>
    <dbReference type="HOGENOM" id="CLU_1468345_0_0_1"/>
    <dbReference type="InParanoid" id="W4JP30"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="184" mass="20755" checksum="D28D96D06E1526AB" modified="2014-03-19" version="1">MCDLGGPHQGSTCNSLQRQSIHPQDSLIGNGESLDEMFNRMEFSNSLQRQSIHPQDSLIGNERIINTKTCGKFLTSNKIQDVRQQLCDCVISLDRPQQDLTTEFSTTRLSASFINKTLQRQDLRHPSTATLLYGKIPTSVTSRFIKRQEQDSRQSATTMLSNVSPRSLISRYSKSLTIQPLHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4JP52</accession>
    <name>W4JP52_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_442745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553322.1">
        <property type="nucleotide sequence ID" value="XM_009555027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JP52"/>
    <dbReference type="GeneID" id="20675483"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_442745"/>
    <dbReference type="eggNOG" id="ENOG502SSE9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070119_0_0_1"/>
    <dbReference type="InParanoid" id="W4JP52"/>
    <dbReference type="OrthoDB" id="3259136at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW74850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="416" mass="45193" checksum="4E7EAB8AE638B5F6" modified="2014-03-19" version="1">MSPTTMTTLSALHTARPRALSVIAEAEWRAQGSTTCGVAFPAPAPAPRATFPLPNELIIDILEYAVVYPTHLAHLALISKRTAELFNTILYRTVLLPTARAILHFARTATSAAPGFLHQHVKRVVFAELHAPLSVHDAVRAILRACTGAHTFALPGAFVSDLLKPDNFPATSSHGAIPLSAPTHLTIGYFDDPDASRRWSAFLPPATARTAPLPPLCTPRAAPALLAGLTHLRLGEPAELFLAPRALLAHLGALPRLTHLHVARQIDANEDNDIAFVQDVAQLLRARPALACVVVGAFLPLFGPARHRLAGFLDDGHEDREGEGAVREKEKGKAEQGAERCRAATIWRLVEALQRTEERLLLVPGRYGSWWHEWQGAGCVANASEPVDFWRETVAEGLRERERGRLAEAVGEGKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQH7</accession>
    <name>W4JQH7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_331260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552761.1">
        <property type="nucleotide sequence ID" value="XM_009554466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQH7"/>
    <dbReference type="STRING" id="747525.W4JQH7"/>
    <dbReference type="GeneID" id="20671641"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_331260"/>
    <dbReference type="eggNOG" id="ENOG502SF9S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_963317_0_0_1"/>
    <dbReference type="InParanoid" id="W4JQH7"/>
    <dbReference type="OrthoDB" id="2546621at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="279" mass="30138" checksum="85AD669C2BA36718" modified="2014-03-19" version="1" fragment="single">QNIDPLSDTTAPRYAVESDEEEDEFNPLFPEGNHQSRNVGIDIKGISPTNAIGGNLVVATGDAGKIWAKGASLEEQQGAVYVNQLQVGLVFRPSWSNATTVVVSELTASLPIWAMSPYAQAVLDYFKPANTVLLDTYPTPVYITAAPVPYRDEAPVRYLSTGPSGTGAPSFAPPNLIQTTSAAFLSIVSVSSPSPSATAFLLPSPRIPRPRPSDLTQQDVSTISEEDIAWPSATMQTVDQAVFEVLGETLKRQWRRKDGAREGKSQLKRREVGDGSMYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQL0</accession>
    <name>W4JQL0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_430652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552620.1">
        <property type="nucleotide sequence ID" value="XM_009554325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQL0"/>
    <dbReference type="GeneID" id="20674470"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_430652"/>
    <dbReference type="eggNOG" id="ENOG502SJRZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044614_3_3_1"/>
    <dbReference type="InParanoid" id="W4JQL0"/>
    <dbReference type="OrthoDB" id="3354175at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="337" mass="37314" checksum="7882225DC4B58862" modified="2014-03-19" version="1">MDMFTDVPLDKAGIVSTVIEGVLYGFSLFMFGITLWVLLYRRPTKTINRPMVVVAIMLFALSTTVRTSLELQLCPAERTNDQHLGVDIHRIILGLIDNRNYPGGPALWFANPSQSTFVTKNVIYYFQTMLGDSVVIYRCYMVWKSIYVIIFPLVMLAGVSVAAIGSGLACSQADPSQGGIFFQRTGQWITAFYASTLSTNLISTSLLAFRIWQINSRVRNNGGSGSTLMPVLLIVIDAGLLYSVTLLSALLCFVNHSNGQYVVLDLVMPIISIAFYMVIIRVGVTKIIPSHQGDPSGFGSVIGQTQNRDYAMRPLEVHITQLTESQKDKVDGRSDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQN1</accession>
    <name>W4JQN1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_412430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552641.1">
        <property type="nucleotide sequence ID" value="XM_009554346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQN1"/>
    <dbReference type="GeneID" id="20673026"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_412430"/>
    <dbReference type="HOGENOM" id="CLU_1396495_0_0_1"/>
    <dbReference type="InParanoid" id="W4JQN1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="195" mass="20809" checksum="98968B914E20F8D0" modified="2014-03-19" version="1">MPLPATPGVSKVESLDTAGEQSQSQSQSQQPPAQPPQPQQLASSRPPHAQRTTPPIYVNQTQTRSRNGSIYVEPQPVSASTLPRTVYSSSSASSSSSIMAPALVLPHRPKAISRASEAAEAFEAEKQRRKLEAARNTEGQAAASAQAAPALKESTNAYDGGLMRRVSLERRPSDRKPAIDGGSLRSRRVISPMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRB9</accession>
    <name>W4JRB9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Esterase/lipase/thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_162783</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552235.1">
        <property type="nucleotide sequence ID" value="XM_009553940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRB9"/>
    <dbReference type="ESTHER" id="9homo-w4jrb9">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="20667793"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_162783"/>
    <dbReference type="eggNOG" id="KOG4389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006586_15_3_1"/>
    <dbReference type="InParanoid" id="W4JRB9"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004104">
        <property type="term" value="F:cholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="47"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW76009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="484" mass="53028" checksum="F0F1B2DB1C4792AB" modified="2014-03-19" version="1">MGNPLSTASMLSTSLAFFFTFILYASLARTTQALSVRSSVLSNSSKSLIVETTSGKARGFLDNITTSISLKKCFGIRYAQDTSGHNRWRPPQPYRYNDTIFNATAFGPACLQGRTDGGSGTSVQSEDCLRINVIAPVGAKELPIYLYSYGGGFDSGASSDPKIDGSFMAAKGIVFASYNYRLSLWAWPHATEIAQANQTQNFGLLDTRAAIRWIQANADVFGGDPAKITLGGESVGAEMTNFYLSAWPDDPIIRGAIMQSSDTSQPQWVLGNQLEAISKNQSCPTGNGQLDCLRGKDGFALQSILLETGNQFQPVIDNITVFKNYVKQTRENRIANVPLLIGTNKVFLSRDIIRDAAWLVRERCFYVHSFVSCSKSNNFNFPFANTTDVLKLYPTSSTLYPSVYNATSAMWRDAHMLCLAHNLGKWRTEALGLPVWRYRFDLVANNLNSLGASIGTFHGEDIQFVMGCGVLDTVIGTQPTVIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRN8</accession>
    <name>W4JRN8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan 1,4-alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">1,4-alpha-D-glucan glucohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glucan 1,4-alpha-glucosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_39327</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal (1-&gt;4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 15 family.</text>
    </comment>
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        <property type="protein sequence ID" value="ETW75536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009554190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRN8"/>
    <dbReference type="FunCoup" id="W4JRN8">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JRN8"/>
    <dbReference type="GeneID" id="20672493"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_39327"/>
    <dbReference type="eggNOG" id="ENOG502QPM2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012173_2_1_1"/>
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    <dbReference type="OrthoDB" id="6123450at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004339">
        <property type="term" value="F:glucan 1,4-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000165">
        <property type="entry name" value="Glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008291">
        <property type="entry name" value="Glucoamylase_SBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF12">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001031">
        <property type="entry name" value="Glu-a-glcsd_SBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00736">
        <property type="entry name" value="GLHYDRLASE15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GH15-like" evidence="13">
        <location>
            <begin position="50"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW75536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="554" mass="60888" checksum="7BC000FBEE92BCD4" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRY9</accession>
    <name>W4JRY9_HETIT</name>
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        <submittedName>
            <fullName evidence="4">Lep6-lignin expressed protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">lep6</name>
        <name evidence="4" type="ORF">HETIRDRAFT_442189</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551917.1">
        <property type="nucleotide sequence ID" value="XM_009553622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRY9"/>
    <dbReference type="GeneID" id="20675422"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_442189"/>
    <dbReference type="eggNOG" id="ENOG502SH62">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046025_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRY9"/>
    <dbReference type="OrthoDB" id="3206554at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="181"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW75651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="340" mass="37636" checksum="47FB85704EEAFF84" modified="2014-03-19" version="1">MGDINVVSTLGAILVGCLLCVALSALVFLQTIIYFYIYRQDLWRIQLIVGTVWALDATHVALTCTATWTYLVLNFGNEDITDFIPITSSIVYENSSACVHTSQQLGIAFTGLVGFIVQAFFTHRVFRLSNNRVLASILIVMTVVRLGAALVTTIEMMRLKSFGVLLDQFAWSISLGLALSSALDLLLSASLSFYLRSNKTGFGTQMDRIVSAIILYTINTGMLTSMMTVSTLICWLVIPNNCAFLAMHFAVSKLHANSLLTTLNTRKVLQEYSKPRFEVGTHQLDTLPRRPSVLVFRKPVKGEHYSLDTGPSKAVERDGTCEERDTMDNRPSVEDKVAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4JT60</accession>
    <name>W4JT60_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_25385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551837.1">
        <property type="nucleotide sequence ID" value="XM_009553542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JT60"/>
    <dbReference type="STRING" id="747525.W4JT60"/>
    <dbReference type="GeneID" id="20669246"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_25385"/>
    <dbReference type="HOGENOM" id="CLU_1768329_0_0_1"/>
    <dbReference type="InParanoid" id="W4JT60"/>
    <dbReference type="OrthoDB" id="3250044at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20108" checksum="29C0E9A86D26E8C6" modified="2014-03-19" version="1" fragment="single">VKWGRGVGMSEARTQDFLAKQVNEDNNSAVRVPVIYLAFRLNNVGYIAMQHVGDRDCTRDDFPKIALAVKHLQQIPSPTSAPGPVNRGPIMHSLFSDCISSVPYSSVDLLEEHINALLASRRWPWRVNFAEKAGIPLSLCIDDLHWGNFRIDSSGLIYSIDHARTNFLPLAFRHLSLAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4JT99</accession>
    <name>W4JT99_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_118682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551239.1">
        <property type="nucleotide sequence ID" value="XM_009552944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JT99"/>
    <dbReference type="GeneID" id="20666601"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_118682"/>
    <dbReference type="HOGENOM" id="CLU_044614_9_3_1"/>
    <dbReference type="InParanoid" id="W4JT99"/>
    <dbReference type="OrthoDB" id="2744793at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="309" mass="33986" checksum="4445D449C8E14E65" modified="2014-03-19" version="1">MSTSGPSSDTTVSSLELVSLGQKIVTNSFGLLFEIWFHGMRQGSNSKANVTMLIVTLTMFSMSTAVLGLNFATVVQEVRHWFILNPSLSLVERERVASNYSARFDWVQDTLFSVEFSIGDSIVLWRAWTLSQASGNTIYIVYVGILLILASFNRQHRRLIKASFGDTARRTRVEKVLVLLVESGVIYFALWVAQIFDFLPITSSSAAAGTASTILSSAGNQLVGLYPTIIVVLVHYQRSLWDSPEVTLNHIKTSISFVSPPSTAVVQSRLTVGEDANHHFDKVVTVHPLESSSTSHASNRTNLEAKSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2024-01-24" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTF1</accession>
    <name>W4JTF1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_118726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551298.1">
        <property type="nucleotide sequence ID" value="XM_009553003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTF1"/>
    <dbReference type="GeneID" id="20666605"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_118726"/>
    <dbReference type="HOGENOM" id="CLU_834348_0_0_1"/>
    <dbReference type="InParanoid" id="W4JTF1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="333" mass="36010" checksum="89F9C1D27795FD87" modified="2014-03-19" version="1">MVLAVPPAAFCLGGPWGESKKVSRVSVFGMLDAGAEERGLRESLKDVATRKDVWLLTSCNWIMMWSWLFPSADAIPESESPKLTDLRREATDYYSSKKRKFGVINALLLPLRFNLQECAVYSGADPFANPTVLKLYGVERYFGKSSERRSADPYCKLELSYGRLTKYYQLATTAKYPLTHDVHVAQHALSLASTCARASVLTGLLSAMNAHNISARVGAFQASAAAIVGRIGKQYQDHVSLIVAPYCTILLHHNSSTVVLDIRESHATGTDRSIAAALSELVPEDDDNGEYEHGDGTRDDALLLHPAGASRAAGGLGGVRSDYQDAGLAADAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTI4</accession>
    <name>W4JTI4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_422770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552414.1">
        <property type="nucleotide sequence ID" value="XM_009554119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTI4"/>
    <dbReference type="GeneID" id="20673849"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_422770"/>
    <dbReference type="HOGENOM" id="CLU_2004229_0_0_1"/>
    <dbReference type="InParanoid" id="W4JTI4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="124" mass="13574" checksum="B021229C47DAEC2A" modified="2014-03-19" version="1">MMHVYALCRSGIHWSCRRITGIMAVGFLSAMSAGVVIIYESLEATTTQVIYNPLVDASLCAISGIPKYVPLFFVPMATLELVLGGLATYTLLRNTGLRSPQPSLTFNVCSYGIRPYTLSYTLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JU08</accession>
    <name>W4JU08_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_446436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551271.1">
        <property type="nucleotide sequence ID" value="XM_009552976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JU08"/>
    <dbReference type="STRING" id="747525.W4JU08"/>
    <dbReference type="GeneID" id="20675689"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_446436"/>
    <dbReference type="eggNOG" id="ENOG502SHQ1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035509_15_2_1"/>
    <dbReference type="InParanoid" id="W4JU08"/>
    <dbReference type="OrthoDB" id="3258294at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
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    </dbReference>
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        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="27"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW76351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="329" mass="37543" checksum="469FF00E898455C5" modified="2014-03-19" version="1">MSGNGITNLPIPYRRALNIGKQSRAGALGLLAYDHFITLDREIELIWRQDKNRQGFWLFVFNRFFPLLWLIFDTIPLARSGIVSSKVCIIYLMCDDIVTLLITISVQSILQLRVYALYGRSRRMLIFLVCCCTVEIAIMAVLVGVTMRKISHLPVVSTPTGCYYSGIFSLSALFWIPILIFEPILCLLILWKAWGEEIMYRFGLGLREFDGRPKATSTPRMVKLIARDSLMYFLAIFVELLINTIIWAKFNRYINIVMPWSCTLPSIFGSRLLLNMREMVLDKGDHNSYILETFAVAEGQMEHIDASSSITMDAPRRNRNSIGVDSAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUH5</accession>
    <name>W4JUH5_HETIT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">HETIRDRAFT_105684</name>
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    <organism evidence="1 2">
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUH5"/>
    <dbReference type="GeneID" id="20666085"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_105684"/>
    <dbReference type="HOGENOM" id="CLU_1310287_0_0_1"/>
    <dbReference type="InParanoid" id="W4JUH5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW77119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="210" mass="23076" checksum="4C309C52FE92D1A9" modified="2014-03-19" version="1">MPPPTCDRAHTLSLPLPIPRSRSHKMRALDALHPRSHKTSVSLYPLAAAAHPFPHSYPLAAAADLRLRSPRRVQVWPLSMPPPTLPALMSAGLSSFNTATHLRPQVWACILLLPPPTLPVLMLSRCRRRSSPPALAQDECVLVFFCCRRPPYLRSYPLAAAAHLACARTLSLPLPILAAHACTRRVRARVLLLLPPTLPALVLSRCCCQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUK9</accession>
    <name>W4JUK9_HETIT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_118835</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009553165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUK9"/>
    <dbReference type="STRING" id="747525.W4JUK9"/>
    <dbReference type="GeneID" id="20666610"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_118835"/>
    <dbReference type="HOGENOM" id="CLU_1240286_0_0_1"/>
    <dbReference type="InParanoid" id="W4JUK9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="223" mass="24638" checksum="C3981A0A76169A94" modified="2014-03-19" version="1">MGRTTLGTDPHSGELERHADALLQQSTISAGNPEMRIATYLNDWLVPVSRSEGLHSKPTLTRPLGTSTMTDDHELSSSIPTNSPSMSTESSFQLSSSLENWALSNQNVPHPEERPMPVPNPRRSPHTVVERPSLRQREIRTAHSNPVTSSSHRVQNLPLSHGGTNEEELPVYRRNEGRKSRGTQAALRRGTTIGGNNPGNYDDADPYYRPDEGGDGYQGPYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4JV96</accession>
    <name>W4JV96_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_222673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550913.1">
        <property type="nucleotide sequence ID" value="XM_009552618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JV96"/>
    <dbReference type="STRING" id="747525.W4JV96"/>
    <dbReference type="GeneID" id="20668665"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_222673"/>
    <dbReference type="HOGENOM" id="CLU_1763171_0_0_1"/>
    <dbReference type="InParanoid" id="W4JV96"/>
    <dbReference type="OrthoDB" id="2799068at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="33"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="148" mass="17011" checksum="A1D0F5F76381A312" modified="2014-03-19" version="1" fragment="single">MNSAPPPNKRRRIDAEPEQGMLRNHSKLFYSDGDTIIQCESILFRVHISRLADHAQWFSKFLTPERERKDNMLFLSLKAGSDDMAAFLTAIYDGLLPDPVLTVNNYIYFCSVLKTAHRYGAESIKNAVLTRFQATWPAKLEDHMVHVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVC7</accession>
    <name>W4JVC7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_37198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550466.1">
        <property type="nucleotide sequence ID" value="XM_009552171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JVC7"/>
    <dbReference type="GeneID" id="20671844"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_37198"/>
    <dbReference type="eggNOG" id="ENOG502QU2T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_1_1_1"/>
    <dbReference type="InParanoid" id="W4JVC7"/>
    <dbReference type="OrthoDB" id="2310150at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW77434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="339" mass="38266" checksum="6E7A2C33C9E124FB" modified="2014-03-19" version="1">MPNQKSAINIVMGAMTFGAPGTEGARVHDLKDVEAILDVFQKHGHIEVDTARTYCSGTSEEYLGKIDWKGRGLKMETKLYPNVRPGVAIDSTREAISHTPESLRKNLERSLKALNTDSLEMWYLHGPDRTTPYEVTLKTVNDLHKEGLFKRFGISNYAAWEVAEIVGICRANGYIQPTAYQGIYNAIHRGVEPELFPCLRKFGISFYEFNPLGGGFFTGRYTSIQDQVEEGARFDPNRGQGKNYRSRYWNEPYFKAIESIRAVADKHGLTMAEIALRWISHHSLLKRAHGDAILIGASSLNHIEQNLVDLEKGPLPDEVVSALDDAWFSVKLYATNYWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWG3</accession>
    <name>W4JWG3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_107444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549809.1">
        <property type="nucleotide sequence ID" value="XM_009551514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWG3"/>
    <dbReference type="STRING" id="747525.W4JWG3"/>
    <dbReference type="GeneID" id="20666245"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_107444"/>
    <dbReference type="eggNOG" id="ENOG502SNUV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1190045_0_0_1"/>
    <dbReference type="InParanoid" id="W4JWG3"/>
    <dbReference type="OrthoDB" id="3046261at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW77779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="233" mass="26329" checksum="A6E659178C1C5147" modified="2014-03-19" version="1">MFVDSFHVTRLAREGYECLTGARRKPFNETLLLSHLTSLDALRAILDAIIARIHLLLPGPNTPFIDRALRSCLFTTSLAWAALVHPVYLELKRRLSITVVAAPPSANADYSEPSLQRMELLSQGLKRMTVTAALDVARNVRDIQDLSFITHLRLVMLDVWARVLIDERETAALMGVDRIQALQWILRGLKLRGWSHVDRSGIIEAVEHHLREDIEATFWAVFDPQLLPISLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWG8</accession>
    <name>W4JWG8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_144363</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549909.1">
        <property type="nucleotide sequence ID" value="XM_009551614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWG8"/>
    <dbReference type="STRING" id="747525.W4JWG8"/>
    <dbReference type="GeneID" id="20667043"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_144363"/>
    <dbReference type="eggNOG" id="KOG4072">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080518_1_0_1"/>
    <dbReference type="InParanoid" id="W4JWG8"/>
    <dbReference type="OrthoDB" id="29558at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW77892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="239" mass="26132" checksum="91AC1227F83B0D56" modified="2014-03-19" version="1">MARGRKILNGDSADKPITSTEPSETKPSPPRASLPALAISAAAQDVDRDEVKVNSANLSELKNACDDALKRFLSRPDLFKQIHLHTDVRLALGWAGVFVAAGTAFYGWKVDFEQSKPVMWVGLVLYVLLTLLQTLYAYFIEGDIVFVGKRKTFDKRIVTERITLSARTLPSTPEKAPHYSLSVAYLRSSGAGKSLLAKGHADAARGYDAFFDAAGVLDQVRFEAWLSELVGRVMEAGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWZ6</accession>
    <name>W4JWZ6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_479259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550084.1">
        <property type="nucleotide sequence ID" value="XM_009551789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWZ6"/>
    <dbReference type="STRING" id="747525.W4JWZ6"/>
    <dbReference type="GeneID" id="20677862"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_479259"/>
    <dbReference type="eggNOG" id="ENOG502SU8B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084280_4_1_1"/>
    <dbReference type="InParanoid" id="W4JWZ6"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046528">
        <property type="entry name" value="DUF6593"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20236">
        <property type="entry name" value="DUF6593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6593" evidence="2">
        <location>
            <begin position="9"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW78082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="218" mass="24957" checksum="57B53E9073D5AF87" modified="2014-03-19" version="1">MQLTLTRESPTNSVYRDQDGRPIYRVETPPKSVGMTSTITRFVSNSSSSHDESMTPARSDTESETDIHLMRLEEEGVAQILWRTFSGTSFKFGERTVLAGTYLPRMGSLGWKRRHRTFTASDGRSYKWRLGNNTSSVSHDFTRRRILGAERTWQLTLNDERKIAVARFHQRSYGVVGKSHKASLEIYPQGEAIVDEILTTFVYVETRRKQENGEAMVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXZ6</accession>
    <name>W4JXZ6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_454355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550379.1">
        <property type="nucleotide sequence ID" value="XM_009552084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXZ6"/>
    <dbReference type="GeneID" id="20676495"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_454355"/>
    <dbReference type="eggNOG" id="ENOG502SE0R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073894_1_0_1"/>
    <dbReference type="InParanoid" id="W4JXZ6"/>
    <dbReference type="OrthoDB" id="2281895at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040030">
        <property type="entry name" value="Ribosomal_mL57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L15, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="31"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="201" mass="21875" checksum="D674438600B6BD44" modified="2014-03-19" version="1">MSTSTPSTASGSSDSPLAHHLNTLFAPLDFNQELSQRILTHMSHKEAVQGHNARFSFMGRRVLHSYLLLFLHSSTASPPSLDYEDVASRALNTYILGEFVAPQWALGDVIRWTPARPVEDKGLTSLKGIGLYKVHGTVVEAVMGGVFHQFGGSVAHRLFHTRLLPHILLPGRSEGLHDSFHEDALATCEKMGGANGPLVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYH1</accession>
    <name>W4JYH1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_419847</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548922.1">
        <property type="nucleotide sequence ID" value="XM_009550627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYH1"/>
    <dbReference type="STRING" id="747525.W4JYH1"/>
    <dbReference type="GeneID" id="20673607"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_419847"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_10_0_1"/>
    <dbReference type="InParanoid" id="W4JYH1"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="30"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW78593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="469" mass="51048" checksum="857153DF71EB84AD" modified="2014-03-19" version="1">MASPPATFKGDWITPEHPDYAKAIARWAVNAERHAKVVAFVKDNDDVHDALQYAKENNLPLAIRGGGHSPSGASSIEGGLVVDLSRYLASVRVDPDKQLAYVGGGAVWGTVDKAAIAHGLASVAGTVDHAALCRISLLLGGGYGYLTGQHGLVIDNLVQATVVIADGSALTANATENPDLYWAIRGGGSNFGVATEFVLQLHPQRRRVFAGLSIFPPTVLAKMNEILAEWWEKGPDEKETILQALTKGPDGKPCIVLVLFWNGSEEEGRAHFKQLFDLGPVVDLCKEIPYEELNTLQNDGVAPGSNYYMKSVFVSGPQPDVAEDILSHLDTLTEKHKLRVIFIYEFFPVNKVLSVPTEATAYVRRPRLSTMVLVRWDNDGSDKLADVRLAATELTNLALSAENKVPPAENTGYGNYISEEIVPVSKDVAPTSRAEALFGENYPRLQKIKNQYDPEGIFSRWYGIKPNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYL6</accession>
    <name>W4JYL6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_172107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548879.1">
        <property type="nucleotide sequence ID" value="XM_009550584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYL6"/>
    <dbReference type="GeneID" id="20668387"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_172107"/>
    <dbReference type="HOGENOM" id="CLU_2886076_0_0_1"/>
    <dbReference type="InParanoid" id="W4JYL6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="63" mass="6820" checksum="E7AC020DD17F0ECB" modified="2014-03-19" version="1">MFCQSPLYASNPSSASRAACSSSESHGMDRSSITDDSEIKGGDGGQERRVVVSISWRRRGLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYN6</accession>
    <name>W4JYN6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_454228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550202.1">
        <property type="nucleotide sequence ID" value="XM_009551907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYN6"/>
    <dbReference type="STRING" id="747525.W4JYN6"/>
    <dbReference type="GeneID" id="20676482"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_454228"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068189_0_0_1"/>
    <dbReference type="InParanoid" id="W4JYN6"/>
    <dbReference type="OrthoDB" id="2670091at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="36058" checksum="92229739AF3F0B18" modified="2014-03-19" version="1">MNDCIITPICLDVKVSNRDHYAGAKATIDSAYKGVIINKTWVRKHRFPTYTLNNPICVRNIDNTINKAGLIRFALDVNLTIWDIHGRTHIERVQMFISNLGKDDLILETDWLKYHDPSIKWRQREVHFDWCPQKCHQPHRFTKEREEPQNDRRLRNVEPWHKPRIRKQATGEPVIRKLAPEPSGFASFDQDLEDEIIITNLKERVPKAYHEFLDIFSKRKSQRLPEYTYWDHAIDLKPTFKPQVPKIYALNSSPIFFIRKKDGKLRPVQDYHHLNSHTIPNVCPLPLIQELLDVIKGATIFSKLDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZ49</accession>
    <name>W4JZ49_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_324012</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549142.1">
        <property type="nucleotide sequence ID" value="XM_009550847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZ49"/>
    <dbReference type="STRING" id="747525.W4JZ49"/>
    <dbReference type="GeneID" id="20671011"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_324012"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="InParanoid" id="W4JZ49"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="4"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW78843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="307" mass="33106" checksum="F3279D0D119187B6" modified="2014-03-19" version="1">MSSRVWLITGTNSGLGLALAEHVLSQGDKVIATVRNIAKLPASLKSVSPLELDLNSSPEDIKAVGLKALEIYGHVDVLVNNAGYGIEVPMEELSPTELVTQFQANFFSAVYLIQSLLPAFRARKSGTVLNISSIASTDPAPALTAYSASKAALDAMSEALAQELTPWGIRIFIVQPGFFLTNWHANATSIGAESRRAAEESRKTGVYADLHGCMGRTLHGNLTVRQVGDPRRAAHRMYDVVTGTGLVEGLQIKGGCPRILLGRDSGERFLEKVQALQENAESTKTIWSATDLDPVRVEEMRKEAGIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZQ2</accession>
    <name>W4JZQ2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_324791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549238.1">
        <property type="nucleotide sequence ID" value="XM_009550943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZQ2"/>
    <dbReference type="GeneID" id="20671083"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_324791"/>
    <dbReference type="eggNOG" id="ENOG502STFQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166304_0_0_1"/>
    <dbReference type="InParanoid" id="W4JZQ2"/>
    <dbReference type="OrthoDB" id="3212455at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="111" mass="12533" checksum="B8D70A0BAFE0A75B" modified="2014-03-19" version="1">MLRYGSVAVALVQRQVMVVQAAHTYDHGDGFLEVYTFAPFHDRVFTATAAPCARIAPGDLLTIFPDTDVFSMPARDTLELPPQAFGEYHELRTRHVRKSERLWAACKAKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZW4</accession>
    <name>W4JZW4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 monooxygenase 32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cyp32</name>
        <name evidence="11" type="ORF">HETIRDRAFT_64305</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548812.1">
        <property type="nucleotide sequence ID" value="XM_009550517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZW4"/>
    <dbReference type="STRING" id="747525.W4JZW4"/>
    <dbReference type="GeneID" id="20678675"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_64305"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_3_1"/>
    <dbReference type="InParanoid" id="W4JZW4"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW79019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="512" mass="57250" checksum="9F5E87A2EEDF4806" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W4K027</accession>
    <name>W4K027_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Terpene cyclase/mutase family member</fullName>
            <ecNumber evidence="7">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_453585</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="7"/>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549348.1">
        <property type="nucleotide sequence ID" value="XM_009551053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K027"/>
    <dbReference type="SMR" id="W4K027"/>
    <dbReference type="FunCoup" id="W4K027">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K027"/>
    <dbReference type="GeneID" id="20676396"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_453585"/>
    <dbReference type="eggNOG" id="KOG0497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009074_2_1_1"/>
    <dbReference type="InParanoid" id="W4K027"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000250">
        <property type="term" value="F:lanosterol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000002">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000003">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF20">
        <property type="entry name" value="LANOSTEROL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
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    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Squalene cyclase N-terminal" evidence="9">
        <location>
            <begin position="86"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase C-terminal" evidence="8">
        <location>
            <begin position="385"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW79079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="734" mass="82230" checksum="6F1943A2468DC07C" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4K058</accession>
    <name>W4K058_HETIT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_453672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="20676405"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_453672"/>
    <dbReference type="HOGENOM" id="CLU_2158759_0_0_1"/>
    <dbReference type="InParanoid" id="W4K058"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="111" mass="11628" checksum="3203761D7D6E55D0" modified="2014-03-19" version="1">MSTKVEQTSEPRGPIAAQISPFTSSASLPSYPFPLPQSPPTPPSRPSSADKTSFASSRTPFQNTLLDHTPAAPPLPAPPSSARSLRHTPAPPSPPPPVPLPRRPAATLHDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4K166</accession>
    <name>W4K166_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Delta12-FADS-like protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="primary">desa12</name>
        <name evidence="3" type="ORF">HETIRDRAFT_49416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009549653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K166"/>
    <dbReference type="GeneID" id="20678106"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_49416"/>
    <dbReference type="eggNOG" id="ENOG502QQNB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033094_0_0_1"/>
    <dbReference type="InParanoid" id="W4K166"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="2">
        <location>
            <begin position="120"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW79557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="419" mass="48856" checksum="2578F080105E5761" modified="2014-03-19" version="1">MNKTSPQSIRTDSRAIGKSYIDGIPNFTPLSWYAFALYTCQIYHVLRWIRVRSMKDIREVIPSHLLVRNTCRGLSVLGRDILVACSIFLCTLHIGRYLDTLVASTTMGLALLYSFRALLWCTYWILQGFALTGIWVIGHECGHGAFSAHGWLCDILGYACHTFLLTPYFSWKISHHRHHMKHASIEYDEPYIPKTRSDLGIPAEDEDEIDYEDYFGDTPIYTLFMLIRQQILAFPAYLVSNVSGQARYPKWTNHYNPDSVLFTREQRSAVLMSNLGILFMGFTLKWGCSRWGTSTVVQYYAMPWICVNHWFVMITYLQHTDPALPHYRSGQWNFQRGAAATMDREFLGFIGHFFLHDVAHFHVIHHFFPKMPFYHAQEATHHLQRLLGEHYHRSRKPVFQALWDNYNNCQFVEDKGQSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4K183</accession>
    <name>W4K183_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zf-UBP-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_420274</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
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                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="263"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="8">
        <location>
            <begin position="300"/>
            <end position="410"/>
        </location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="ETW79100.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="637" mass="68284" checksum="A32C9A689D02E1C3" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4K195</accession>
    <name>W4K195_HETIT</name>
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        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_124446</name>
    </gene>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="9"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="487" mass="53805" checksum="EBB2F50CFB35CABE" modified="2014-03-19" version="1">MSLQHTPIAELDSIYETLQKTFRDGVARPLEWRKHQLYQLARMAQENSDAFAASMHADLGKPAMEAILGEIGPLVERSIISAQSLDEWAKPEPVPVPEWQQPWAPTLHKTPKGVVLIIAPWNYPMILSLQPLMGAIAAGCPAVIKPSEVCPTYSSLLASLLPRYLDQSAYRVVNGSVPEVSHLLKLKWDHIFYTGNGSVARIVSAAAAKHLTPVTLELGGKSPVLVDANCDLKLAAKRAFFGKTTNAGQICICPDYVILPRSAKDEFVAGLQDAYDTFYPEGALKSESFGSIVSKLHYDRLLDLQKRTRAKAVIGGKTDGRNRIEPTVYVDVEDDDSLMEGEIFGPLFPIVLVDDINEGIELINKRPHPLVLYAFTNDPKVKQALIDRTRSGTLIFNDTIQQLSVNEIPFTGIGESGQGYQILKYTYDGFTHLRASIDIPAESEPILSPRYAPYTPENIKLLTDATLNQPIPKSVYPKAEQNGKARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4K325</accession>
    <name>W4K325_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_321136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547003.1">
        <property type="nucleotide sequence ID" value="XM_009548708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K325"/>
    <dbReference type="GeneID" id="20670725"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_321136"/>
    <dbReference type="HOGENOM" id="CLU_2776228_0_0_1"/>
    <dbReference type="InParanoid" id="W4K325"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW80223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="69" mass="7892" checksum="32259AD38C5C34EF" modified="2014-03-19" version="1">MLLRRRQRAAILAAIANGTYVPPSPPSRANQSVFGEKPRMYEVFLDEEKACSQKWASLAIHHSRSLRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3B3</accession>
    <name>W4K3B3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_475911</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547079.1">
        <property type="nucleotide sequence ID" value="XM_009548784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3B3"/>
    <dbReference type="GeneID" id="20677652"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_475911"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_9_3_1"/>
    <dbReference type="InParanoid" id="W4K3B3"/>
    <dbReference type="OrthoDB" id="10016252at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF4">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="9"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="411"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW80313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="661" mass="73521" checksum="430A9F316A4FFA48" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3F5</accession>
    <name>W4K3F5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_419510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548405.1">
        <property type="nucleotide sequence ID" value="XM_009550110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3F5"/>
    <dbReference type="STRING" id="747525.W4K3F5"/>
    <dbReference type="GeneID" id="20673573"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_419510"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_1_1_1"/>
    <dbReference type="InParanoid" id="W4K3F5"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF812">
        <property type="entry name" value="2OG-FE(II) OXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="177"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW79865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="364" mass="40890" checksum="9E973C83EAEF6682" modified="2014-03-19" version="1">MTANFTNVPVLDYALLSSPTSRPDFIAQLRNALINVGFLYLSHPPVSQSDIDALVAYIPGLFALPQESKDAIQMANSPHFLGYSRLGVERTKRALDQREQFDFATPHINKWTEGEPEYLKLWGPSQWPKEAELPGFKETVLRYLDQVQKLSFEFISLIAEALGLQPDGLARFYDTDEFMQHRSKIVKYPSQDEVSSDQGVGPHFDAGFLTFLFQASSHPGLQVQNLAGQWIDVPPIPYTFVINIGKALETATKGLTRATSHRVLSPAKGSTPRYSIPFFQNIGQRFKLSESALQFPPEILKLKEERGEPATSDSVNFSEYDREPSGFVALIGRIKSHPDVAQRHYPDLFKQFFPEGLPAHGEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4K484</accession>
    <name>W4K484_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_319300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547349.1">
        <property type="nucleotide sequence ID" value="XM_009549054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K484"/>
    <dbReference type="STRING" id="747525.W4K484"/>
    <dbReference type="GeneID" id="20670586"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_319300"/>
    <dbReference type="eggNOG" id="ENOG502RZZ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082172_0_0_1"/>
    <dbReference type="InParanoid" id="W4K484"/>
    <dbReference type="OrthoDB" id="266663at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="130"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW80622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="236" mass="25316" checksum="16A8485462D050C8" modified="2014-03-19" version="1" fragment="single">PSKPELSQLSSISERPPHDAAPGIPLPPTPAPSVPTIGNLFLSSCPGKKVRLNGPVRGRGAICRDLKQDLERMKDAGVGCVVCCLDDDELEFLGAPWPVYSQVANELGLDILRIPMPEGLAPVSAHTLDAQLARLISTYTLNGAHVLVHCRGGVGRAGLIACCWMLRLGLCGTPLPARRGVGEVRAGTLQLVERVVAIVRRRRSLKAIETYEQVKFLVGYVEFMAERAAEGGRLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4C1</accession>
    <name>W4K4C1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphatase phospho-type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_418592</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547323.1">
        <property type="nucleotide sequence ID" value="XM_009549028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4C1"/>
    <dbReference type="STRING" id="747525.W4K4C1"/>
    <dbReference type="GeneID" id="20673489"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_418592"/>
    <dbReference type="eggNOG" id="KOG3120">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068983_1_0_1"/>
    <dbReference type="InParanoid" id="W4K4C1"/>
    <dbReference type="OrthoDB" id="10267182at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016965">
        <property type="entry name" value="Pase_PHOSPHO-typ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889:SF12">
        <property type="entry name" value="LP01149P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889">
        <property type="entry name" value="PHOSPHATASE, ORPHAN 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06888">
        <property type="entry name" value="Put_Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031051">
        <property type="entry name" value="PyrdxlP_Pase_PHOSPHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW80594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="28740" checksum="F7ED73A2753C51AE" modified="2014-03-19" version="1">MAKDIERQLIVFDFDWSLADQDTDRWIFEVLAPDIRRKMKTLKEEIQWTDLIAQSLRELHERGGTREDIEGALKIMPFHPAMVRGVKAVKAASKPATTFFCLSNANSVFITTILQSKGLQDLFTEIVTNPAEWDPSGLLKLRRRVDPAGPQHSCKVGCSPNMCKGDELEAFLARHRPDFDRIIYVGDGSNDFCPILRLRSQDMILCRQYRGLEKRIAKEGEKEGLKCQVRYWAGAWEVEEIFKQLPNVIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4T3</accession>
    <name>W4K4T3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_440480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547508.1">
        <property type="nucleotide sequence ID" value="XM_009549213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4T3"/>
    <dbReference type="GeneID" id="20675265"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_440480"/>
    <dbReference type="HOGENOM" id="CLU_1475347_0_0_1"/>
    <dbReference type="InParanoid" id="W4K4T3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="183" mass="20727" checksum="462A86A006619119" modified="2014-03-19" version="1">MTISCATRDHSASTPSQIRVQASPPCKDVERELQVMRDRHSMHAAELAAARSAKRKLEDACERERVARRRVERQMSDLERALARAERREESALEQIKSEVEARRVAEERAIAERKARVEAEEAIKEREKERQAAERELEKVQEKQREGLLPMFESLAGMFQRAAMGSVNMAGDGTRVPSSSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4K509</accession>
    <name>W4K509_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">LAG1-DNAbind-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_385547</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Su(H) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547598.1">
        <property type="nucleotide sequence ID" value="XM_009549303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K509"/>
    <dbReference type="STRING" id="747525.W4K509"/>
    <dbReference type="GeneID" id="20672246"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_385547"/>
    <dbReference type="eggNOG" id="KOG3743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008944_0_0_1"/>
    <dbReference type="InParanoid" id="W4K509"/>
    <dbReference type="OrthoDB" id="5600360at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1450:FF:000003">
        <property type="entry name" value="Related to J kappa-recombination signal binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1450">
        <property type="entry name" value="LAG1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015350">
        <property type="entry name" value="Beta-trefoil_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036358">
        <property type="entry name" value="BTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040159">
        <property type="entry name" value="CLS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015351">
        <property type="entry name" value="RBP-J/Cbf11/Cbf12_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037095">
        <property type="entry name" value="RBP-J/Cbf11_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038007">
        <property type="entry name" value="RBP-Jkappa_IPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10665">
        <property type="entry name" value="RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09270">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09271">
        <property type="entry name" value="LAG1-DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20144">
        <property type="entry name" value="TIG_SUH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01268">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01267">
        <property type="entry name" value="LAG1_DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110217">
        <property type="entry name" value="DNA-binding protein LAG-1 (CSL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RBP-J/Cbf11/Cbf12 DNA binding" evidence="8">
        <location>
            <begin position="245"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-trefoil DNA-binding" evidence="9">
        <location>
            <begin position="398"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="609"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="479"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="644"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="697"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW80903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="890" mass="94870" checksum="6C6F5FA69C3C0074" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5D7</accession>
    <name>W4K5D7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Concentrative nucleoside cotransporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_62005</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546976.1">
        <property type="nucleotide sequence ID" value="XM_009548681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5D7"/>
    <dbReference type="STRING" id="747525.W4K5D7"/>
    <dbReference type="GeneID" id="20678578"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_62005"/>
    <dbReference type="eggNOG" id="KOG3747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016813_1_1_1"/>
    <dbReference type="InParanoid" id="W4K5D7"/>
    <dbReference type="OrthoDB" id="6075923at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="SODIUM/NUCLEOSIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 28 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="512"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter N-terminal" evidence="9">
        <location>
            <begin position="171"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside transporter/FeoB GTPase Gate" evidence="11">
        <location>
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            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW81129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="177" mass="20083" checksum="90B5E74603CC3372" modified="2014-03-19" version="1">MHSLYARINNITATLSTCMMVLLAGIACSSSLFTADPKGTLNISSVQVFPGQTRRIPGRTQDFAFVNFNLTADLTPLFNWNTKQLFLYVGAEYTNAKGVKNEVVIWDRIVRRKEDAYIQVQGKNKYPFRDPSEKFRNPEPAEYTLKYNLMPYVGLLTYGEAARTTPIPFPEAKERLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5U8</accession>
    <name>W4K5U8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">40S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_320181</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547441.1">
        <property type="nucleotide sequence ID" value="XM_009549146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5U8"/>
    <dbReference type="FunCoup" id="W4K5U8">
        <property type="interactions" value="484"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K5U8"/>
    <dbReference type="GeneID" id="20670651"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_320181"/>
    <dbReference type="eggNOG" id="KOG3311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103849_0_1_1"/>
    <dbReference type="InParanoid" id="W4K5U8"/>
    <dbReference type="OrthoDB" id="1702480at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.910.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_uS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003140">
        <property type="entry name" value="PRK04053.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW80725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="17933" checksum="211E4FF98DB1CE4A" modified="2014-03-19" version="1">MSLVLPEAHQQFQHILRLLNTNVDGKRKIMYALTEIKGVGRRYSNLVCKKADVDLNKRAGELNSDELERLVTIIQNPTQFKIPTWFLNRQRDIVDGKNSQVLSNGVDSKLRDDLERLKKIRAHRGLRHSWGLRVRGQHTKTTGRRGKTVGVSKKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4K605</accession>
    <name>W4K605_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_46209</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546944.1">
        <property type="nucleotide sequence ID" value="XM_009548649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K605"/>
    <dbReference type="GeneID" id="20677181"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_46209"/>
    <dbReference type="eggNOG" id="KOG1110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042860_3_2_1"/>
    <dbReference type="InParanoid" id="W4K605"/>
    <dbReference type="OrthoDB" id="899at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF115">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="3">
        <location>
            <begin position="16"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW81204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="121" mass="13306" checksum="6FD26B8014CE8B0B" modified="2014-03-19" version="1">MQAERSDLAPPKDDPFTLDQLKQFDGSDPSKPIYVAIKGTVFDVSHKSDTYGPGKSYNLFAGKDASKALGKSSLKPEDAVPDYSDLPENEMKVLNDWHVFFTKRYNVVGKVVDLPAAVANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7A1</accession>
    <name>W4K7A1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_33736</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
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                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Lunden K."/>
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                <person name="Rouze P."/>
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                <person name="Velez H."/>
                <person name="de Vries R.P."/>
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        </source>
    </evidence>
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        <source>
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                <person name="Asiegbu F."/>
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                <person name="Bouzid O."/>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
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                <person name="Durling M."/>
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                <person name="Fossdal C.G."/>
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                <person name="Hietala A."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546552.1">
        <property type="nucleotide sequence ID" value="XM_009548257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K809"/>
    <dbReference type="GeneID" id="20670392"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_317124"/>
    <dbReference type="eggNOG" id="ENOG502S3G3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_676251_0_0_1"/>
    <dbReference type="InParanoid" id="W4K809"/>
    <dbReference type="OrthoDB" id="8955945at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="279"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="334"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW81962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="406" mass="45342" checksum="C157FA5E63316DCD" modified="2014-03-19" version="1">MSGQASTSTNTPSATVQPGRGKVKLPDNYTGDRIESQKFMLQCLLLFAAESDRYKTDQDKISLVLSCMRYGTAGAWAENFLLKSVGADPPTDLGTWKDFLAKFKLQFRETGKTDKARSALMAFSQGRMTVDEYSNQFILIAADADISDKEQVPYFQRGLDPRVMDKIYDKEVQPKDTIQDWINTACEIDGRLRARTAQKAILANSTSFRSDYLNRFHNQISPRYNSTNAPRRMNNQVVDMDIDATRKRNAESQKRKFDGKQPKCYNCGRRGHYSADCRSARRGVPPVRGNSKRRLGTTGRGNRAVDLEGEDDAPAMGNQAGIYRGMETEDVHRNNQRVPQPGPSMERPHSTPSGRPQTNHGQRTMLPNGRRGDGGVSHSARIGAVLGELGEDEAREVILGHAERFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8H8</accession>
    <name>W4K8H8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="10">DOHH</shortName>
            <ecNumber evidence="10">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LIA1</name>
        <name evidence="13" type="ORF">HETIRDRAFT_51265</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="10">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="10"/>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545835.1">
        <property type="nucleotide sequence ID" value="XM_009547540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8H8"/>
    <dbReference type="FunCoup" id="W4K8H8">
        <property type="interactions" value="355"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K8H8"/>
    <dbReference type="GeneID" id="20678173"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_51265"/>
    <dbReference type="eggNOG" id="KOG0567">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053974_0_0_1"/>
    <dbReference type="InParanoid" id="W4K8H8"/>
    <dbReference type="OrthoDB" id="421002at2759"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000099">
        <property type="entry name" value="Deoxyhypusine hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="11">
        <location>
            <begin position="77"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW81655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="332" mass="36355" checksum="A040AEF1E5519B04" modified="2014-03-19" version="1">MSAGLVVSDSDLENLEDTLLNKSGGIPLHNRFRALFTLKALKNEDAIRIISKGFQDPSALLKHELAYCLGQIEHEAALPTLERVLADATEDPMVRHEAAEAMGAISSTSSLPILKKYIRDPERAVRETCEIALARIEWDNSEEGRRHQSAQAIQTFTSIDPAPPTSGLLSGKPKSEDLSEASISRLQSQLVDTKLPLFERYRAMFALRNIGTAEAVDALASGFTDDSALFKHEIAFVFGQLLSPHSVPALLQVLQSSSESDMVRHEAAEALGGIATPEVLPYLKEYINKEDVPVVVRESCQVALDMYEYENSDQFQYANGLDGTLLSQVVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4K930</accession>
    <name>W4K930_HETIT</name>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">HETIRDRAFT_409798</name>
    </gene>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546859.1">
        <property type="nucleotide sequence ID" value="XM_009548564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K930"/>
    <dbReference type="GeneID" id="20672807"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_409798"/>
    <dbReference type="HOGENOM" id="CLU_1927895_0_0_1"/>
    <dbReference type="InParanoid" id="W4K930"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="131" mass="14055" checksum="F856DF3CA784F695" modified="2014-03-19" version="1">MNLPPPSSPPPAFSCSSPLPLPASSALGVRPRSADERGAASEARRGQHGRDGVRGIRARRRVAAVRAERREAAVEVEAEVERKLARGVVVVDEAAAERRVWEVDAWHAERVASARRARAGAYGSGPRTSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4KA00</accession>
    <name>W4KA00_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_459061</name>
    </gene>
    <organism evidence="6 7">
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        <lineage>
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            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546482.1">
        <property type="nucleotide sequence ID" value="XM_009548187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KA00"/>
    <dbReference type="GeneID" id="20676968"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_459061"/>
    <dbReference type="eggNOG" id="ENOG502SVRI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027659_0_0_1"/>
    <dbReference type="InParanoid" id="W4KA00"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="575"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="276"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="542"/>
            <end position="565"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
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            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="104"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="161"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
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        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW81891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="655" mass="65065" checksum="6BFED92C654149E3" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4KA72</accession>
    <name>W4KA72_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_126207</name>
    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009546766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KA72"/>
    <dbReference type="FunCoup" id="W4KA72">
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    </dbReference>
    <dbReference type="STRING" id="747525.W4KA72"/>
    <dbReference type="GeneID" id="20666933"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_126207"/>
    <dbReference type="eggNOG" id="KOG1509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040416_0_2_1"/>
    <dbReference type="InParanoid" id="W4KA72"/>
    <dbReference type="OrthoDB" id="10267058at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213:SF5">
        <property type="entry name" value="BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW82732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="240" mass="26077" checksum="DFBF00AD25073D75" modified="2014-03-19" version="1">MAPKREPAVLPHALRVPGLTKLTGKRVVLASASPRRREILRTFGLAPEVVPSTFEEDLDPMSFEDVHEYPVATATHKAVEVYERLVEENPDDAPDLVIGADTVVLTHAQAALSDAPFISAQGARPEVLEKPAGRADNLRMLLDMNGAVLFPVLTAPGYAIRSIEERSLVYFADNPTYLLEAYADSGEGADRAGGFAVQGLGGLLIRKVDGDFQNVVGFPAASFFRFLDLLVEEDDEFLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAP0</accession>
    <name>W4KAP0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA-binding protein VTS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">RNA-binding protein vts1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HETIRDRAFT_150381</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA-binding protein involved in post-transcriptional regulation through transcript degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546707.1">
        <property type="nucleotide sequence ID" value="XM_009548412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAP0"/>
    <dbReference type="STRING" id="747525.W4KAP0"/>
    <dbReference type="GeneID" id="20667361"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_150381"/>
    <dbReference type="eggNOG" id="KOG3791">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017632_1_0_1"/>
    <dbReference type="InParanoid" id="W4KAP0"/>
    <dbReference type="OrthoDB" id="2155283at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09556">
        <property type="entry name" value="SAM_VTS1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000033">
        <property type="entry name" value="Protein vts1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057327">
        <property type="entry name" value="Vts1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037635">
        <property type="entry name" value="VTS1_SAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF5">
        <property type="entry name" value="PROTEIN SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25479">
        <property type="entry name" value="Vts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SAM" evidence="14">
        <location>
            <begin position="631"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="377"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="589"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="393"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="418"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETW82151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="703" mass="72340" checksum="83E0E105B9BBAC70" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAS9</accession>
    <name>W4KAS9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Onanonoxo-7-onima-8-eninoihtemlysoneda</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_316475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545202.1">
        <property type="nucleotide sequence ID" value="XM_009546907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAS9"/>
    <dbReference type="STRING" id="747525.W4KAS9"/>
    <dbReference type="GeneID" id="20670336"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_316475"/>
    <dbReference type="eggNOG" id="KOG1401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010794_0_0_1"/>
    <dbReference type="InParanoid" id="W4KAS9"/>
    <dbReference type="OrthoDB" id="425114at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03109">
        <property type="entry name" value="DTBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000080">
        <property type="entry name" value="Bifunctional dethiobiotin synthetase/adenosylmethionine-8-amino-7-oxononanoate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684:SF3">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13500">
        <property type="entry name" value="AAA_26"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW82893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="807" mass="87761" checksum="2FE4EDB02DA84B69" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBP7</accession>
    <name>W4KBP7_HETIT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_316714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ETW83159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBP7"/>
    <dbReference type="GeneID" id="20670353"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_316714"/>
    <dbReference type="eggNOG" id="ENOG502SC0I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164170_1_0_1"/>
    <dbReference type="InParanoid" id="W4KBP7"/>
    <dbReference type="OrthoDB" id="2141050at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39218">
        <property type="entry name" value="OXIDOREDUCTASE 14 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39218:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 14 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844201" evidence="1">
        <location>
            <begin position="17"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="90" mass="9644" checksum="08726CD815A95719" modified="2014-03-19" version="1">MALLTSIFGFSLFGLAARLGQLGIQKRNLFDNPGGHVISMLAFGYAGYWAHQWDERAAVLIAEKRAEIAARRQRAIAAAEADGAAALADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBR7</accession>
    <name>W4KBR7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Multicopper oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">HaMco2</name>
        <name evidence="11" type="ORF">HETIRDRAFT_157048</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
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        <property type="protein sequence ID" value="ETW83287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545556.1">
        <property type="nucleotide sequence ID" value="XM_009547261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBR7"/>
    <dbReference type="SMR" id="W4KBR7"/>
    <dbReference type="STRING" id="747525.W4KBR7"/>
    <dbReference type="GeneID" id="20667688"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_157048"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_7_1_1"/>
    <dbReference type="InParanoid" id="W4KBR7"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13857">
        <property type="entry name" value="CuRO_1_Diphenol_Ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13883">
        <property type="entry name" value="CuRO_2_Diphenol_Ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13904">
        <property type="entry name" value="CuRO_3_Diphenol_Ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF414">
        <property type="entry name" value="ADR239WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844395" evidence="7">
        <location>
            <begin position="21"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="91"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="216"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="461"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW83287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="648" mass="69860" checksum="1FAECF4017B0E534" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCJ7</accession>
    <name>W4KCJ7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Type 1 phosphatases regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_165784</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the YPI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545748.1">
        <property type="nucleotide sequence ID" value="XM_009547453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCJ7"/>
    <dbReference type="STRING" id="747525.W4KCJ7"/>
    <dbReference type="GeneID" id="20668007"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_165784"/>
    <dbReference type="eggNOG" id="KOG4102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098333_0_2_1"/>
    <dbReference type="InParanoid" id="W4KCJ7"/>
    <dbReference type="OrthoDB" id="307488at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW83503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="173" mass="19053" checksum="76C9AFD8551D8A77" modified="2014-03-19" version="1">MSHTVAHGPSTSAPSDGSRTLVLHDTQPESSRHDSNGNGHDVGPLRLRGAHRNQQRVSWEEDVIDNEGMGKKKTKICCIYHRPKQFDESSDEDSSDSDSDSGSDSGPCRTSHHRHGHHHHGHRTPPHAPSHGNGLRMKDSENGGVIHELEDGDDRNAYESMPSKKGKGKHIPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCP4</accession>
    <name>W4KCP4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ASTRA-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_238895</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat ASA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545394.1">
        <property type="nucleotide sequence ID" value="XM_009547099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCP4"/>
    <dbReference type="FunCoup" id="W4KCP4">
        <property type="interactions" value="175"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KCP4"/>
    <dbReference type="GeneID" id="20668814"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_238895"/>
    <dbReference type="eggNOG" id="KOG0322">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041940_0_2_1"/>
    <dbReference type="InParanoid" id="W4KCP4"/>
    <dbReference type="OrthoDB" id="7668193at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW83110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="403" mass="43839" checksum="6F7AF21068FE2A3F" modified="2014-03-19" version="1" fragment="single">PPTPIHLIRSHASPVSAVCFSDDNERIYSGDSSGLVVITSTRSLRALASWNAHTDGILGIQEWNEQLITHSRDHKLHVWKRPTQGHSSVGDSALLPGLPNPALAYSMDVNSLNYCRFSLLPLGKSSPIAAEEALIALPNLIESSLADIWMLPSQERIHAAIGKGKLDSLPMPGTDGRGIKNSTGIIMSMHLLPGRPPMGAAPSSSESRSKHPQLLTSYENGSVSMWQYSVDKEKSIEGIGWERLWSTKMHVESGLLMAMAASANHHLALSVSADHLIARYNLAALDDDANSVGAACTAHRTKRPGNGSIALREDGRVCAVGGWDGKIRLYSAKTLKPLGTLVYHKDSVQAIAWARLPQHRPMEVLKDCDSEDDMSSAEKENRERWLVSGGKDGRLAIWGLMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCS5</accession>
    <name>W4KCS5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF427 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_315349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545422.1">
        <property type="nucleotide sequence ID" value="XM_009547127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCS5"/>
    <dbReference type="STRING" id="747525.W4KCS5"/>
    <dbReference type="GeneID" id="20670216"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_315349"/>
    <dbReference type="eggNOG" id="ENOG502SGFY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059611_0_0_1"/>
    <dbReference type="InParanoid" id="W4KCS5"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="entry name" value="Domain of unknown function (DUF427)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34310:SF9">
        <property type="entry name" value="BLR5716 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34310">
        <property type="entry name" value="DUF427 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G02220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF427" evidence="1">
        <location>
            <begin position="18"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="DUF427" evidence="1">
        <location>
            <begin position="130"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="242" mass="27737" checksum="24CF004FAB64895F" modified="2014-03-19" version="1">MTVPFPPAGHVEDSQKRVRVLFNKHFIVDSKKAKLVWEHQHYPSYFFAASEVPTKYLQQPAKSKPDTYDIVVDGKRAEGAAVVYTDGAFKGLVKLVFGKMDAWFEEDDQIFVHPKDPYKRVDVSQSSRHVRVEVDGVEVANTTKPRLLFETGLPVRTYIPKTDVRTDLLEPTDLTTACPYKGVANYYSVVLPSGERRENIVWWYRTPQLECAEIRGFAAFYDEKVDVWVDGEKVQRPKSVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCV0</accession>
    <name>W4KCV0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_316158</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDE2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545200.1">
        <property type="nucleotide sequence ID" value="XM_009546905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCV0"/>
    <dbReference type="STRING" id="747525.W4KCV0"/>
    <dbReference type="GeneID" id="20670293"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_316158"/>
    <dbReference type="eggNOG" id="KOG2827">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060603_1_1_1"/>
    <dbReference type="InParanoid" id="W4KCV0"/>
    <dbReference type="OrthoDB" id="547031at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053822">
        <property type="entry name" value="SDE2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024974">
        <property type="entry name" value="Sde2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF1">
        <property type="entry name" value="SPLICING REGULATOR SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22782">
        <property type="entry name" value="SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13019">
        <property type="entry name" value="Sde2_N_Ubi_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sde2 ubiquitin" evidence="10">
        <location>
            <begin position="3"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="SDE2-like" evidence="11">
        <location>
            <begin position="83"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="83"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW82891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="214" mass="22951" checksum="088412D54BEA2F3E" modified="2014-03-19" version="1">MSTTVLVSTFSPFPTLAFSAPSETTIDELYGVLSTRYPFLPPTSDLFLAPHSRALSNGSSTLSSLHSPDEALVSLRLTPRMRGGKGGFGSQLRAAGGRMSSQKTSNNDSCRDLSGRRLSTIKEAKKLAEYLEQEPARKKAASEAQRAKLEALERKLGLGKNGGPSGSGEPETLAGKKHRLDDTEYLEQSREIVDNVKNAVAAGQIISLITLNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCW5</accession>
    <name>W4KCW5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF572-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_163319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545213.1">
        <property type="nucleotide sequence ID" value="XM_009546918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCW5"/>
    <dbReference type="FunCoup" id="W4KCW5">
        <property type="interactions" value="357"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KCW5"/>
    <dbReference type="GeneID" id="20667838"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_163319"/>
    <dbReference type="eggNOG" id="KOG2990">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050402_0_1_1"/>
    <dbReference type="InParanoid" id="W4KCW5"/>
    <dbReference type="OrthoDB" id="360327at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF2">
        <property type="entry name" value="SPLICING FACTOR YJU2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW82906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="37340" checksum="28BEF7DE44A37207" modified="2014-03-19" version="1" fragment="single">QGFNKYYPPDYDGEKHKSLNSYRGKHALGDRARKIDQGILITRFELPFNIWCGTCNAHIGMGVRYNAEKKKIGKYYSTPIFSFRCKCHLCSGWFEIQTDPQNTRYVVVSGARQKDEDWDPEENGGYAIHDTEGKDVAVDPLIALEKSVDSQNFATKVQAPRIEQLQNMSEHYNADPYAHSLRLRKRFREEKKVEKQKEEADNNIKARYGLPSELSLLRDDDTSIQEASDAWAKARSDRVREEASKRRKLDLDKPLLPSSARSASGSRKQSGSSSKVKLSLPNSSSDMVSSLRARILSNTSRQSGVFLTSIPQPGKRFPDEKAAGFLKKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDC0</accession>
    <name>W4KDC0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="3 12">2.5.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_48027</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="3 12"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543227.1">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
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        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00012221"/>
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            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00060338"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR004967"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW83847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="463" mass="51160" checksum="C41AFCF3E9C193E9" modified="2014-03-19" version="1">MTTKNPRKRFVGSKSARPSKPGVTSVVANQIPEDILSDVQLNGAIQQLPSNYSFEIHKTIHHVRKNGAKMVALQMPEGLQMFACTIVDIIERFTDALAVIMGDVTYGACCIDDYTAVALGCDMLVHYGHSCLVPMDQTTIKTLYIFVEIAIDAAHLAQTVRINFPGDRLRFHAELLDSEENKGASSKSTRLALVSTIQFVAALSRLKDDLTPMLYTGRYDAIIPRSKPLSPGEILGCTAPRLSDDVDALIYLGDGRFHLESIMIANPTVPAFRYDPYSKKFTRERYAHEEMKTVRNDAVQTARKSIDTFAHRSATNAETTSVAKSLSDPLDEPPMWGVILGTLGRQGSFKQLQAITHQLTQSHTPIPYIPILLSELSPAKLSLFSPHISTFVQTSCPRLSIDWGYAFDRPLLTPYETSVAIGQAIGWMDYTEDGEGKKIDGVYPMDFYAAGTPWAISRTTASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDR8</accession>
    <name>W4KDR8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_458764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009547411.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_458764"/>
    <dbReference type="HOGENOM" id="CLU_500213_0_0_1"/>
    <dbReference type="InParanoid" id="W4KDR8"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
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        <location>
            <begin position="334"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="473"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
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        <location>
            <begin position="214"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="493"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW83460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="545" mass="58702" checksum="11527E7B3A4A278C" modified="2014-03-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KE55</accession>
    <name>W4KE55_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_314180</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009545510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KE55"/>
    <dbReference type="GeneID" id="20670102"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_314180"/>
    <dbReference type="eggNOG" id="ENOG502QU9T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029940_1_0_1"/>
    <dbReference type="InParanoid" id="W4KE55"/>
    <dbReference type="OrthoDB" id="3162524at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10938">
        <property type="entry name" value="CE4_HpPgdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037950">
        <property type="entry name" value="PgdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561:SF1">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="7">
        <location>
            <begin position="28"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW84093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="303" mass="34576" checksum="F973EDE3C5AA0715" modified="2014-03-19" version="1">MPRKVLIGFGVDVDAVAGWLGSYGGEDSPLDISRGMFAGEVGVPRLLKLFAKYKLKTTWFIPGHSLETFPEQMAAVRDAGHEIGLHGYSHENPVSMTFEQQKDILDHTYNLLTVFNNGVPPKGSVAPWWETSKEGTELLLNKGLEYDHSNMAHECAYYLRDQDTWTKIDYTAKAHTWMKPLQKGKETGIVEIPANWYLDDLPPMMFIKASSNSHGWVNARDVEQLWKDTFEYLYREEESFIFPITIHPDVSGRPHVLLMLERFIEWVNAHDGVSWVPMIEMANEFRSRVKPREGAAMPRGFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4KE59</accession>
    <name>W4KE59_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipid transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_46877</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543191.1">
        <property type="nucleotide sequence ID" value="XM_009544896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KE59"/>
    <dbReference type="FunCoup" id="W4KE59">
        <property type="interactions" value="187"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KE59"/>
    <dbReference type="GeneID" id="20677250"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_46877"/>
    <dbReference type="eggNOG" id="KOG3177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079653_1_1_1"/>
    <dbReference type="InParanoid" id="W4KE59"/>
    <dbReference type="OrthoDB" id="292693at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="5">
        <location>
            <begin position="34"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW83605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="209" mass="23136" checksum="F6533FB697CB77F1" modified="2014-03-19" version="1">MRRTFITLPDFSSLSPFSNSVPEAQTYHERKILPYVRSELYRVVADVSSYHKFIPFCTSSRILESSSPLQAHLTARDKPDVLEMDGELTVAFLALKESYVSKVTCKPYESVQAVALSSTPLFKNLTTTWRFQPASPQSPHMSMDGPTAQTQKISAGDEAGPTLLTLDLSYAFANPLHAAVSSAFFGQVSKLMVEAFEKRCLAVYGLGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEB1</accession>
    <name>W4KEB1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_472615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543857.1">
        <property type="nucleotide sequence ID" value="XM_009545562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEB1"/>
    <dbReference type="GeneID" id="20677467"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_472615"/>
    <dbReference type="eggNOG" id="ENOG502SS2X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_959954_0_0_1"/>
    <dbReference type="InParanoid" id="W4KEB1"/>
    <dbReference type="OrthoDB" id="3251949at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="290" mass="32205" checksum="2012A5B2A1AB9C6E" modified="2014-03-19" version="1">MEKIEAVDIETVSLGAILFEGIMQCTCQGVIFAQVCRYWEIPLDDTGRMKAFVAVLLILASLQTGLTIYKLWHALVEHLHWSKSPLYFCDILLNGLICTISETFLVRRCWKATSKNRWVLVGLASIAATAFVAILYLSIAIARGTRSTFPKSNNARIPLMSDLFFDTVLAFNVWIFASLVLDLSVTSILMVYLWKSKTGLGYLDKALKHIIGITWESAAIPSILMIISVILYHCKAVSALVTFDTCLRPLTWSRPLEAGGATPFLAIHSPDREILHPGYAPNTQLSPEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEL1</accession>
    <name>W4KEL1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_62989</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543284.1">
        <property type="nucleotide sequence ID" value="XM_009544989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEL1"/>
    <dbReference type="FunCoup" id="W4KEL1">
        <property type="interactions" value="521"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KEL1"/>
    <dbReference type="GeneID" id="20678626"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_62989"/>
    <dbReference type="eggNOG" id="KOG1467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_3_1_1"/>
    <dbReference type="InParanoid" id="W4KEL1"/>
    <dbReference type="OrthoDB" id="10254737at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233:SF14">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW84272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="446" mass="47386" checksum="D74052BE7D13A357" modified="2014-03-19" version="1">MTKAERRELQEQQRAAKAAAKASGVPQASQGASASAKGTGNKQAQPSTPTSSGQKKGARGEAPAPSLVQARGGALVVAAAKGTKDAKAGVNAAEGAVGRSRGLRIFSHFALQKTASHVIKGDIHPAIVRLGLKFSEFKICGANARCIATLSAFKQVIQDYITPPNTTLSRHLMTHLSAQISHLVSARPMSVTMGNAIRELKLEISGSDIDLPQQDAKDALCVKIDNYIRDRIIIADQVIQETAMKKIHDGDVILTYARSSVVEKVLLQAWAEGTQFSVVVVDSRPMLEGKRLLSVLAAANIPCTYLLLPALNAIITEVSTVFVGAHSLHSNGAVFSRAGTALVAMQAKRHSVPVIVCCETYKFSEGVQLDSFTKNELAPVGDLFSSFPLARPRDSLLLQNRPNLEILNPLYDLTPPSSITAVVTEVGVIPPDSISSIPLALGRLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEN3</accession>
    <name>W4KEN3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">14-3-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_432754</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543317.1">
        <property type="nucleotide sequence ID" value="XM_009545022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEN3"/>
    <dbReference type="FunCoup" id="W4KEN3">
        <property type="interactions" value="469"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KEN3"/>
    <dbReference type="GeneID" id="20674633"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_432754"/>
    <dbReference type="eggNOG" id="KOG0841">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058290_0_0_1"/>
    <dbReference type="InParanoid" id="W4KEN3"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11309">
        <property type="entry name" value="14-3-3_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000002">
        <property type="entry name" value="14-3-3 protein epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00797">
        <property type="entry name" value="1433_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="5">
        <location>
            <begin position="5"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW83536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="255" mass="28789" checksum="C6E57079CCC6515C" modified="2014-03-19" version="1">MPESREDSVYLAKLAEQAERYEEMVENMKRVASSDQELTVEERNLLSVAYKNVIGARRASWRIVSSIEQKEESKGNEAQVSMIKGYREKIESELAKICEDILDVLDKHLIPSAASGESKVFYHKMMGDYHRYLAEFALGDKRKDSADKSLEAYKSASDVAVTELPPTHPIRLGLALNFSVFYYEILNSPDRACHLAKQAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQDSADKPSEKDDAGDAADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFD3</accession>
    <name>W4KFD3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_432852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543511.1">
        <property type="nucleotide sequence ID" value="XM_009545216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFD3"/>
    <dbReference type="STRING" id="747525.W4KFD3"/>
    <dbReference type="GeneID" id="20674637"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_432852"/>
    <dbReference type="HOGENOM" id="CLU_490058_0_0_1"/>
    <dbReference type="InParanoid" id="W4KFD3"/>
    <dbReference type="OrthoDB" id="3270840at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="556" mass="59521" checksum="B21A528257BF81BA" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFH3</accession>
    <name>W4KFH3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_408623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544260.1">
        <property type="nucleotide sequence ID" value="XM_009545965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFH3"/>
    <dbReference type="GeneID" id="20672692"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_408623"/>
    <dbReference type="eggNOG" id="ENOG502QSDS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_683454_0_0_1"/>
    <dbReference type="InParanoid" id="W4KFH3"/>
    <dbReference type="OrthoDB" id="2386201at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035361">
        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019021">
        <property type="entry name" value="Mms22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28122">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SUBSTRATE RECEPTOR MMS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28122:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SUBSTRATE RECEPTOR MMS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09462">
        <property type="entry name" value="Mus7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW84612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="403" mass="45744" checksum="ACCC92C36E3243C3" modified="2014-03-19" version="1">MEDILDWSGGMADSLITAYLEIDVQGPKVRVADQKRQAIRSLEILLACVRSVIETTSRGNEPTYPLPGYLQGSWVHRVLSVPGLAYDPVVGRALRELLQTFFDARNGAMPAADSSAPVNNSESQDEYGAFDLDLEDPDVLAALGGPVEPSPIEIKENATREIIASSVSPAIYHFISKYPTTPEDDPMPRQSWDDMDGWVDRWVDYSQICVKSGKQDWSSYLELGAFSWEKILDESWRRHVGLRFMYRLLQVDPHSYSAYRNQYLKVWIISLVCVNVTVEHQYTSLLLKTDKMNHPLLRDLPTTIDATLSRTEFQGFRLPFLRVVFKHLSDDLQINFGIPSGHNQLYLSYLASAFSAMRNNYEDKDGFVYRDFCKSVFVALKEFPLISAHSTLSYSVLWGKSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFL6</accession>
    <name>W4KFL6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_449455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543567.1">
        <property type="nucleotide sequence ID" value="XM_009545272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFL6"/>
    <dbReference type="STRING" id="747525.W4KFL6"/>
    <dbReference type="GeneID" id="20675951"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_449455"/>
    <dbReference type="eggNOG" id="ENOG502SYR1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1563069_0_0_1"/>
    <dbReference type="InParanoid" id="W4KFL6"/>
    <dbReference type="OrthoDB" id="3253535at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="18790" checksum="505EC1E12C49E32C" modified="2014-03-19" version="1">MPSLTSSLPWTTSSESPSSTWQPLLSPSSQSTPPSPRPSLASPPLHIPEPALQPEGAVEPPKTASRRTPPPSAVPQPRFRFNGNTHSVDIPLPCPGGRPFAPEMITISLKRGDRMDIVADAWHLEEDCHYEWHISLPRAIDISSLRARFNDDGTLLTIDVRNTRYSNRAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGX9</accession>
    <name>W4KGX9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_313703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544590.1">
        <property type="nucleotide sequence ID" value="XM_009546295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGX9"/>
    <dbReference type="GeneID" id="20670056"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_313703"/>
    <dbReference type="HOGENOM" id="CLU_1514081_0_0_1"/>
    <dbReference type="InParanoid" id="W4KGX9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="200" mass="22103" checksum="8DA13D7FB475ABE9" modified="2014-03-19" version="1">MVMDTRSSSRQSGTTVRTSCYRPFRLPLPRHPRLEPPRIRLLSPLAPPRMCGPTTPPIRPPLPRLAYPRLFALPPSMPRTPATQCARPPPVAPRQEAQIRLSRAPTPPRSYPSPSQSSTTLSPVDHPTSPSTHDSLETMPDQLNVDTWLQDKAGRELAARCPGRPVALRGVKVPVDKSCCRNGRVLSAAARLPTAQIRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4KH85</accession>
    <name>W4KH85_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_115390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542091.1">
        <property type="nucleotide sequence ID" value="XM_009543796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KH85"/>
    <dbReference type="GeneID" id="20666479"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_115390"/>
    <dbReference type="eggNOG" id="ENOG502SUDH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_688982_0_0_1"/>
    <dbReference type="InParanoid" id="W4KH85"/>
    <dbReference type="OrthoDB" id="3263038at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="222"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW85218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="400" mass="42885" checksum="36EDBABADC6FE536" modified="2014-03-19" version="1">MSAVSVSTNTLPSNVPKLDPKGTNWVIFSIRFKDAITTKKKWGHFDGTAPCPSFTVATGATLSEKQLTTIQTWNDDEASAKYLLSQRLPDSTVIRTNKIAMIATHWASIVTDYTAKSAFAQTALRKEFLDLCMPRSGDVDTFFKDLAAKKEKLATCGSSAEKKFDIQVLMDLVVEEYEHLTREQGANTGGSNSSSNANDVALLVMGGSGERGKSKRPFQGACWNCGEKGHIWDKCPKLKKTDGSSSSKSGLKTTGSANVAVDYDSNSDGFWIAESMSGALEVDDDEGHGSMLSLYSVSGSDASDSVPTLDDDEGGWFSEMEEDEGGEFEAWAGDMCPEVYGDVARDLASSISGVNPDSVHNDTSVTNMTDEPELSAAVFPGVNSAAYSRHCHAIFDSGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHR4</accession>
    <name>W4KHR4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_438216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542125.1">
        <property type="nucleotide sequence ID" value="XM_009543830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHR4"/>
    <dbReference type="GeneID" id="20675027"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_438216"/>
    <dbReference type="HOGENOM" id="CLU_2831479_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHR4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="66" mass="7596" checksum="DA916F1C0D589ED8" modified="2014-03-19" version="1">MRRESFDTPLHALKIHAQGSGSIRARSITVQMAKEFDSCYIWENSELFHAPTSIMLLILEMEADRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHY9</accession>
    <name>W4KHY9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS monocarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_63436</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543296.1">
        <property type="nucleotide sequence ID" value="XM_009545001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHY9"/>
    <dbReference type="GeneID" id="20678638"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_63436"/>
    <dbReference type="eggNOG" id="ENOG502RWDV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012596_1_0_1"/>
    <dbReference type="InParanoid" id="W4KHY9"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF160">
        <property type="entry name" value="NODULIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845403" evidence="6">
        <location>
            <begin position="28"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW84696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="501" mass="53474" checksum="888ABC893CC24AB7" modified="2014-03-19" version="1">MADAPSLLSLPRLATLLTSLLVALSSGTNYVVSAYAPQLGSRLHLSHTQLNLVALSGNVGVYTSGPVWGKLVDSRGPQILLIGAFVCLLAGYSGIRSLYDAGLDEGERLSNMHLSLMILCGFLTGLGGNAGLTSAINSTAKSFPDRLRATAVGVVISGFGLSAFFFTSLSHIFFPGDTSRFLLILALGTSLPMILGFFFIRPIPLPAGDDTHTLEHGAADQYQRLSTNETAGVGRALWTSGDFWLMFSICMLLSGTGLMYINNVGSISQALYTKDNTSYDEVAAAAFQAAQVSMISIMNFIGRILVGVAADFTKSRLHYPRSVCITAVAGLFVLSQAITLGMDDVRHLWRASALLGLAYGSMFGLFPTICIEWFGLAHFSENWGYVSLSPVIGGNLFSLAFGRNLDAHDSPRASAPANATLLPADAPSSLRLMRRAGLPSAHQCLDGRDCYVASLYLTLGACVVALGLSVWAGWRDTRDRRARGPEVLVEEVVWEVPGAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIS1</accession>
    <name>W4KIS1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_145007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544572.1">
        <property type="nucleotide sequence ID" value="XM_009546277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIS1"/>
    <dbReference type="GeneID" id="20667057"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_145007"/>
    <dbReference type="HOGENOM" id="CLU_3068944_0_0_1"/>
    <dbReference type="InParanoid" id="W4KIS1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="53" mass="5581" checksum="61EE16CD716F18C2" modified="2014-03-19" version="1">MLSPRASPCPVKPKLDSSSPRPSATECPRSLSSLELTHPPSPATQIRPRSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKC4</accession>
    <name>W4KKC4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_448780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542604.1">
        <property type="nucleotide sequence ID" value="XM_009544309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKC4"/>
    <dbReference type="GeneID" id="20675888"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_448780"/>
    <dbReference type="HOGENOM" id="CLU_2171401_0_0_1"/>
    <dbReference type="InParanoid" id="W4KKC4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="110" mass="12207" checksum="1DC6814AA59C8BFF" modified="2014-03-19" version="1">MGLTEPDIFRSHLPPSRLGVPKVDPSLSVAVRFRERPPTRLPTRSFSERSKRIHHGAATAGLCQIVTLAAIARDRRSPASTDDSPPLLLSRFSVSTRARWRVMLRSVAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKT3</accession>
    <name>W4KKT3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_244238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540483.1">
        <property type="nucleotide sequence ID" value="XM_009542188.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKT3"/>
    <dbReference type="STRING" id="747525.W4KKT3"/>
    <dbReference type="GeneID" id="20669033"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_244238"/>
    <dbReference type="HOGENOM" id="CLU_161753_1_0_1"/>
    <dbReference type="InParanoid" id="W4KKT3"/>
    <dbReference type="OrthoDB" id="3261594at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="68" mass="7537" checksum="D195CC6B5A0E5163" modified="2014-03-19" version="1" fragment="single">VKKKVAELSGITSIIHNICPNTCAAYTSPYADLDKCPLCHRSQYDEVHLALTGKKKPRQQFHTISLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLC3</accession>
    <name>W4KLC3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_307397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540520.1">
        <property type="nucleotide sequence ID" value="XM_009542225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLC3"/>
    <dbReference type="GeneID" id="20669487"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_307397"/>
    <dbReference type="HOGENOM" id="CLU_2503865_0_0_1"/>
    <dbReference type="InParanoid" id="W4KLC3"/>
    <dbReference type="OrthoDB" id="2449121at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="86" mass="9959" checksum="F2BB52C49854BE32" modified="2014-03-19" version="1" fragment="single">YKHSYCKIYKVKFEDAKKVAQQCLSRLTQIDSDAILGLITFCFFRSKNWPPPFYRGNFHKGHFLTPFASLSPNLNSVCPKKFHLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLS9</accession>
    <name>W4KLS9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_468302</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="2"/>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540674.1">
        <property type="nucleotide sequence ID" value="XM_009542379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLS9"/>
    <dbReference type="FunCoup" id="W4KLS9">
        <property type="interactions" value="549"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KLS9"/>
    <dbReference type="GeneID" id="20677223"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_468302"/>
    <dbReference type="eggNOG" id="KOG1936">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025113_4_0_1"/>
    <dbReference type="InParanoid" id="W4KLS9"/>
    <dbReference type="OrthoDB" id="1906957at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="6">
        <location>
            <begin position="84"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="363"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW86674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="582" mass="64131" checksum="B4050C10CC31728D" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMI9</accession>
    <name>W4KMI9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-flanking protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_145292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540982.1">
        <property type="nucleotide sequence ID" value="XM_009542687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMI9"/>
    <dbReference type="GeneID" id="20667073"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_145292"/>
    <dbReference type="eggNOG" id="ENOG502S2II">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063290_1_1_1"/>
    <dbReference type="InParanoid" id="W4KMI9"/>
    <dbReference type="OrthoDB" id="2290255at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056138">
        <property type="entry name" value="DUF7721"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477:SF1">
        <property type="entry name" value="BETA-FLANKING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24845">
        <property type="entry name" value="DUF7721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7721" evidence="2">
        <location>
            <begin position="57"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW87032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="216" mass="22145" checksum="B0CE6AE9DF82F44C" modified="2014-03-19" version="1">MENFVNLAKKGLDAYEQHQKSSSSNSESNYGKTGGAEYNSPHHSEQGRPSSGSPQFDHDDVVKTAQEHGSGDSSLFSSAMSFISSNKGEHQNPIDEDAAQEAHKKAYHEDSASNMDASSIGSAAALQILKKFTSGSSSGSSGGSQSQLISMAMAEATKLFDKSGGASSGNKQDAVNSAAMTVVKLMVQSKFSGGGTTGGSSSGGLGSLLSLASKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMK4</accession>
    <name>W4KMK4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_443814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543027.1">
        <property type="nucleotide sequence ID" value="XM_009544732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMK4"/>
    <dbReference type="GeneID" id="20675542"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_443814"/>
    <dbReference type="HOGENOM" id="CLU_1787097_0_0_1"/>
    <dbReference type="InParanoid" id="W4KMK4"/>
    <dbReference type="OrthoDB" id="2637024at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="143" mass="16216" checksum="4F0AADB79337DBA1" modified="2014-03-19" version="1">MPSINPPYPSFTLVMSNNMGSSGTSRPSAYRGSHSGRYHPYPRAYPLHYEDHMMTVDYRYSEPPQACPRSSFALPAIIVEDCDLEIEAGAADDTDTAVERRARPNIKNIGDYILAFVLAVRRKCRRALTVKNIEDELRFEFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMQ7</accession>
    <name>W4KMQ7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_468908</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541044.1">
        <property type="nucleotide sequence ID" value="XM_009542749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMQ7"/>
    <dbReference type="FunCoup" id="W4KMQ7">
        <property type="interactions" value="705"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KMQ7"/>
    <dbReference type="GeneID" id="20677263"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_468908"/>
    <dbReference type="eggNOG" id="KOG1498">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033860_2_0_1"/>
    <dbReference type="InParanoid" id="W4KMQ7"/>
    <dbReference type="OrthoDB" id="268763at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000070">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="268"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW87102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="474" mass="53973" checksum="623599CA9A844516" modified="2014-03-19" version="1">MAETRKQEKDFAKEVDELVPQATTLAESGQLGDALEKLLALEKQTRNASDQASTTRLAKSVLELAYAARDYTQLNSNINFLSKKQGQYKVTIQAMVELSMGWLEDIKARDGVEKWLELVETLRAVTEGKLFLETPRARVTLLLSHYHESLVETPTPTSPPPRDSLITASELLADLEVETYSSMERREKTEFILEQMRLLIAVARLKDAESGSEGKDSLGGGETEWVKVRVGSRKINEGFLSEAAHEDLKLKYYDMMVQHGLHHSAYLDVAKYYHKVWETPSIKEDVSGKGRIALEHIVYFVVLASHDNEQSDMMHRLFTNPALSRLELHYNLVKSFTTPELMRWPGIESIYGPFLRKSAVFEVDKHWQDLHTRVIEHNIRVIAQYYTRITLARLTTLLDLSPQQTEDTLCRLVVSGTIWARIDRPSGVVNFRNKRSAEDVMNDWSADMQKLLGFVEKTWMGMNAAQAAQSRVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNE9</accession>
    <name>W4KNE9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="6">2.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_413641</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + acetyl-CoA = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="6">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.12" evidence="6"/>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541241.1">
        <property type="nucleotide sequence ID" value="XM_009542946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNE9"/>
    <dbReference type="FunCoup" id="W4KNE9">
        <property type="interactions" value="391"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KNE9"/>
    <dbReference type="GeneID" id="20673122"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_413641"/>
    <dbReference type="eggNOG" id="KOG0557">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_10_2_1"/>
    <dbReference type="InParanoid" id="W4KNE9"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000003">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006257">
        <property type="entry name" value="LAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01349">
        <property type="entry name" value="PDHac_trf_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 6" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="9">
        <location>
            <begin position="163"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="114"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW87327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="452" mass="48104" checksum="D7DC71FC647D904E" modified="2014-03-19" version="1">MSASSLARIFARKIHVSARRHALTRMNMPAMSPTMTEGGIASWKKAEGDSFAAGDVLLEIETDKAVIDVEAADDGILAKIIAKDGAKGVAVNAPIAILAEEGDDLSGAADLAAQALSESAEPPKKEEKAPEPSKSEETPKPAPAESQPKSESKSQLAKGERIFASPIAKKIALERGIPLAKVKGTGPEGRIIREDVEKYQPSAAAAAPGAPSAPAVQTPDYVDIPTTSMRRTIGSRLTQAKVEAPHYYLTVDINMDKVTKLREVFNKSFGEKDKAAKLSVNDFIVKAVSKALEDVPEANTAWLGEVIRQYKKADISIAVATPNGLITPIVKDVGSKGLATISSEAKALAKKARDGKLQPHEYQGGTFTVSNLGMFDISHFTAIINPPQSCILAVGSTQPTLVPAPEEERGFKTVNLMKVTLSCDHRTVDGAVGARWLTAFKGYLENPLTFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNF5</accession>
    <name>W4KNF5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_306181</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540881.1">
        <property type="nucleotide sequence ID" value="XM_009542586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNF5"/>
    <dbReference type="STRING" id="747525.W4KNF5"/>
    <dbReference type="GeneID" id="20669386"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_306181"/>
    <dbReference type="eggNOG" id="KOG2499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010969_1_0_1"/>
    <dbReference type="InParanoid" id="W4KNF5"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06564">
        <property type="entry name" value="GH20_DspB_LnbB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052764">
        <property type="entry name" value="GH20_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43678:SF1">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43678">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845610" description="beta-N-acetylhexosaminidase" evidence="7">
        <location>
            <begin position="26"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase bacterial type N-terminal" evidence="9">
        <location>
            <begin position="29"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="8">
        <location>
            <begin position="184"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR625705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW86915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="719" mass="78362" checksum="13CE75E11AB9DDF8" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNK5</accession>
    <name>W4KNK5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_306247</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541298.1">
        <property type="nucleotide sequence ID" value="XM_009543003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNK5"/>
    <dbReference type="GeneID" id="20669390"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_306247"/>
    <dbReference type="eggNOG" id="ENOG502QRIN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020021_1_1_1"/>
    <dbReference type="InParanoid" id="W4KNK5"/>
    <dbReference type="OrthoDB" id="7344096at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044159">
        <property type="entry name" value="IQM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31250">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN IQM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31250:SF27">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN IQM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="418"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="418"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW87392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="480" mass="54438" checksum="9D4FDA088B1642C8" modified="2014-03-19" version="1">MSKSDRSHTNTDGISQREAAERIQRVWRSRNRASSKKYMTPDARWNDALLTVEMEASDIGAQREGGNGAKMRWRRAAVTTQRLHDRNSVLRNEGLDIPGAAHKRLETQHWLELVDGKHRYGSNLKYYFKRWKDSDTEDNFFKWLDRGDGKKLSLKECPREQLEKEVRVEFCLNYLVNIDSDGKLRWARNGHLVDTSAGHWKDAGRDEGIVPLDAPDAPEHQGSNTSALSPVSSSLSSAEENAIAHYVGPQKGKYGLTRALRSHFTIHGIIDKLLRKTLRRNTWIYVSDMNFNLFVGIKEPGTFQHSSFLAGGLVTSAGLISVKEGMIHTLSPLSGHYRTSIDHFRSFLKALERRGVNMEKVEKSKAETALWLIEHLAKMRKHQSELFSRGKNKAKSTMGEAGELGDAVVSGSWKRDILEGRKKQRPEGKAKETHRSQNSESQEKREEQRGEKAEWPVSGGPHESDVQTREKHNGDHSSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNV6</accession>
    <name>W4KNV6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_377315</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="ETW86731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_009540726.1">
        <property type="nucleotide sequence ID" value="XM_009542431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNV6"/>
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        <property type="interactions" value="453"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KNV6"/>
    <dbReference type="GeneID" id="20671873"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_377315"/>
    <dbReference type="eggNOG" id="KOG0469">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_11_2_1"/>
    <dbReference type="InParanoid" id="W4KNV6"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
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    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03700">
        <property type="entry name" value="EF2_snRNP_like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF10">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="17"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW86731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="842" mass="93477" checksum="05C59A4AC1B96B80" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4KP09</accession>
    <name>W4KP09_HETIT</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_431573</name>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_009542769.1"/>
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    <dbReference type="HOGENOM" id="CLU_004580_0_0_1"/>
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    <dbReference type="OrthoDB" id="10255344at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1395"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1503"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1574"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="1651"/>
        </location>
    </feature>
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        <location>
            <begin position="113"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="617"/>
            <end position="700"/>
        </location>
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    <feature type="coiled-coil region" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
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            <end position="1180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1230"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1359"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1402"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1622"/>
            <end position="1639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW87125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1651" mass="186596" checksum="3A76F58C9699BDAF" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W4KP47</accession>
    <name>W4KP47_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_59609</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540415.1">
        <property type="nucleotide sequence ID" value="XM_009542120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KP47"/>
    <dbReference type="FunCoup" id="W4KP47">
        <property type="interactions" value="352"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KP47"/>
    <dbReference type="GeneID" id="20678481"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_59609"/>
    <dbReference type="eggNOG" id="KOG0975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031922_0_1_1"/>
    <dbReference type="InParanoid" id="W4KP47"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000005">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW87479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="416" mass="45296" checksum="5344700B533684D6" modified="2014-03-19" version="1">MAFSLRAHHARTLLLLKGPSWAVASRTLSTRWDSSAAARVLADIDPAKLQIERTTAPKPLPPSANLKFGHNFTDHMLTIPWTQKEGWAAPKIVPYGPLSLDPSCTVFHYAQCLFEGLKAYRDASGRVTMFRPDMNMKRMNRSAQRIALPTFDGDALLELLKQLIRLDKHWIPQEKGHSLYIRPVLIGTQNTIGITPPDSALLYVICSPVGPYYPDGFKPVALHGTTEHVRASPGGTGEFKIGANYAPGIYPQKKAAHLGYVQNLWLYGPEHNLTEVGTMNLFVVFRRDDGALELVTPPLDGMILPGVTRDSVLSLARAHASGAHPLPSLPPNLAVSERGVTMREVRAAAQAGRLVELFGTGTAAVVSPVDRIGYEGADVEIPVAADGMGPVSRALWTELVGRQMGEIPSEWSVVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPU6</accession>
    <name>W4KPU6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proteasome activator PA28 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_377824</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PA28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541025.1">
        <property type="nucleotide sequence ID" value="XM_009542730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPU6"/>
    <dbReference type="STRING" id="747525.W4KPU6"/>
    <dbReference type="GeneID" id="20671903"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_377824"/>
    <dbReference type="eggNOG" id="KOG4470">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062515_1_0_1"/>
    <dbReference type="InParanoid" id="W4KPU6"/>
    <dbReference type="OrthoDB" id="6591885at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008537">
        <property type="term" value="C:proteasome activator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000045">
        <property type="term" value="P:regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.180:FF:000002">
        <property type="entry name" value="Proteasome activator complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.180">
        <property type="entry name" value="Proteasome activator pa28, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003186">
        <property type="entry name" value="PA28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036997">
        <property type="entry name" value="PA28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009077">
        <property type="entry name" value="Proteasome_activ_PA28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003185">
        <property type="entry name" value="Proteasome_activ_PA28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036252">
        <property type="entry name" value="Proteasome_activ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10660:SF2">
        <property type="entry name" value="LD45860P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10660">
        <property type="entry name" value="PROTEASOME REGULATOR PA28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02252">
        <property type="entry name" value="PA28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02251">
        <property type="entry name" value="PA28_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47216">
        <property type="entry name" value="Proteasome activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome activator PA28 N-terminal" evidence="4">
        <location>
            <begin position="10"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator PA28 C-terminal" evidence="5">
        <location>
            <begin position="113"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="49"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW87081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="28729" checksum="F0CA897873A3F66A" modified="2014-03-19" version="1">MAGQPKVDADTAAQLEEFRKAVAAEADIVIFRTFPNKVRQLQQLIDSTSSTSSPFHLSHASSSTDATVYPPPGSVDSSQEPDAKKRKRATDDKGVAVSNANGTHHARFPNLMLSNKHLVQVHAKVKEECEHLAELCDKVKLWINLTMPKIEDGDNFGVQIQEEVLSELHRSQESAYNLRDGARQSHLNRAKIASKIIKYPHIEDYALALKEHDEKQLYVARQNLFDLRNIYAVISDILHKNIAKIRSPKGNNGASLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPU9</accession>
    <name>W4KPU9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_470021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541675.1">
        <property type="nucleotide sequence ID" value="XM_009543380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPU9"/>
    <dbReference type="GeneID" id="20677320"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_470021"/>
    <dbReference type="HOGENOM" id="CLU_2399935_0_0_1"/>
    <dbReference type="InParanoid" id="W4KPU9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW87817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="93" mass="10354" checksum="86B68C6A0B822EFB" modified="2014-03-19" version="1">MPYRAAVIPPEPQPREANWLLGRVGLSNLDHVGNDFGLDQACFGPSTTAIPTWHMRRRSVLADRAVLESAWNGGSMTRYMNQYSLLIPEITLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KR05</accession>
    <name>W4KR05_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_145515</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541390.1">
        <property type="nucleotide sequence ID" value="XM_009543095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KR05"/>
    <dbReference type="FunCoup" id="W4KR05">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KR05"/>
    <dbReference type="GeneID" id="20667086"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_145515"/>
    <dbReference type="eggNOG" id="KOG2909">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017554_0_0_1"/>
    <dbReference type="InParanoid" id="W4KR05"/>
    <dbReference type="OrthoDB" id="6605928at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1460.10">
        <property type="entry name" value="subunit c (vma5p) of the yeast v-atpase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1180">
        <property type="entry name" value="Vacuolar atp synthase subunit c, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW87496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="393" mass="45138" checksum="A93E769970632D67" modified="2014-03-19" version="1">MPSDQSTWLIAAPQDGDSDGLLQELHTKLSQQSKSFSYNNIGQLYIPSFKTGTLDSLIALSEELPKQEAFFTATVAKIVETLRNLLNNDPAKLSQHILVDERNVDDYVLKEWRWNDGRYGVQRGLREIVEVLNKEMTSIDNVMKTKLNSYNLAKGSLTQMQRKKTGNLSVRSLVDVVKQADFIQDSEYLETLLVAVPKNLIKEWNAKYERLTSMVVPRSASSVSSDDEYTLFSVVIFRRVHDEFVQKCRENKYLVREFHFSEESLLKEREDLVTADTTEKELWTELLRLSRTNFSESFQILVHLKVVRLYIESVLRYGLPANYIGLAIKPEPKATKRTLALLHEYFAYLSPRSGSKNSSGASVGADDFVGEYQTLLEQEYFNFVLYEVPWIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W4KRF3</accession>
    <name>W4KRF3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_246092</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CYC8/SSN6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541525.1">
        <property type="nucleotide sequence ID" value="XM_009543230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KRF3"/>
    <dbReference type="STRING" id="747525.W4KRF3"/>
    <dbReference type="GeneID" id="20669101"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_246092"/>
    <dbReference type="eggNOG" id="KOG1124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003728_4_1_1"/>
    <dbReference type="InParanoid" id="W4KRF3"/>
    <dbReference type="OrthoDB" id="418911at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000403">
        <property type="entry name" value="General transcriptional repressor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000078">
        <property type="entry name" value="Transcriptional corepressor Cyc8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051630">
        <property type="entry name" value="Corepressor-Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017:SF1">
        <property type="entry name" value="LD02225P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4 9" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="174"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="246"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="280"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW87651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="379" mass="43226" checksum="D19B5554224E12A1" modified="2014-03-19" version="1" fragment="single">GNVAEQMGDLEHALSAYENALRHNPMSVPGLTQVAGIARVKENFPMAVEYFQRVIHLQQDNGEIWSALGHCYLMQDDLQKAYSAYQQALYSLPNPKENPKLWYGIGILYDRYGSLDNAEEAFSSVLRMDKEDFDKSNEVLFRLGIIYKQQSKYDDSLRCFDRILRNPPSPLANADIWFQIGHVYEQQGDHVRARDAYERVVAENPVHAKVLQQLGWLFHQDGTPFQNQDVAIHHLTKSLEADPADAQSWYLLGRAYMAGQKYNKAYEAYQQAVYRDGRNPTFWCSIGVLYFQINQFRDALDAYSRAIRINPYIPEVWFDLGSLYESCNNQISDAIDAYARAAELDPQNVSVTSRLQLLKHSQATGAQLPAAPPPQDVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JM59</accession>
    <name>W4JM59_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_331741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553133.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JM59"/>
    <dbReference type="GeneID" id="20671680"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_331741"/>
    <dbReference type="HOGENOM" id="CLU_1378296_0_0_1"/>
    <dbReference type="InParanoid" id="W4JM59"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW74637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="198" mass="22072" checksum="2CEAA61979EB6688" modified="2014-03-19" version="1">MPAIEFVYLSSCLKALGQPTEEMLAYIELYHETAPIDIKDADNSRDLQAHVTLASERLAHLTIEQVKAGAGRFNTAMMVDLGMRAILCLVYHRLNRFAKSKDLLDLAMAVKLADCAARIGQPTPVIIRADETLDLAISSIMEGPHGLENPDVANICKIVPECDALEKCLRRRNRVLVEDLRNQALKKMRAPNKYQCAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4JME6</accession>
    <name>W4JME6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_332488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553135.1">
        <property type="nucleotide sequence ID" value="XM_009554840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JME6"/>
    <dbReference type="GeneID" id="20671735"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_332488"/>
    <dbReference type="HOGENOM" id="CLU_3032622_0_0_1"/>
    <dbReference type="InParanoid" id="W4JME6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW74639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="55" mass="5954" checksum="97FD51B6D281B641" modified="2014-03-19" version="1">MPPEFSQLTILYSCTANKNSAGMTTTALYALFSAPTTLEASSGQGDILLFWEISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMV4</accession>
    <name>W4JMV4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_68012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553077.1">
        <property type="nucleotide sequence ID" value="XM_009554782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JMV4"/>
    <dbReference type="GeneID" id="20678839"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_68012"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_4_1"/>
    <dbReference type="InParanoid" id="W4JMV4"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW74887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="38146" checksum="0BEE26BD615E8DBA" modified="2014-03-19" version="1">MAKLSILQFIRDQYKTVPPVVKVDLSGKTVLVVGANTGLGLEAAKHFASMNPEKLLLACRNAEKGQRAIEAIEAATGFTRSELRIVDLSKFSSVVEFANKCDNDRERLDVYVYNAGVYFADYEATEDGWETTLQVNHLSCMLLSILLVPCLFRAVGAPLSPSPYPRMVIVASDAHFWATLSEEELGSNNMILKLNDREYCNSSVMGDRYVVSKMLNVVFARELAARLPSDSPIIVNSVDPGYCISELRRSFSAPRMAFDKLMELALARTTEQGSRQLVWAAVGGQGREPELRGAYVSSADIKDPSDVVLDKTGAVTQKRIFDESIAVLSKVSPRFQAILEEHRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNT9</accession>
    <name>W4JNT9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pinin/SDK/MemA protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_482515</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pinin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553218.1">
        <property type="nucleotide sequence ID" value="XM_009554923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNT9"/>
    <dbReference type="STRING" id="747525.W4JNT9"/>
    <dbReference type="GeneID" id="20678033"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_482515"/>
    <dbReference type="eggNOG" id="ENOG502S8HT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068517_0_0_1"/>
    <dbReference type="InParanoid" id="W4JNT9"/>
    <dbReference type="OrthoDB" id="330772at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039853">
        <property type="entry name" value="Pinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006786">
        <property type="entry name" value="Pinin_SDK_MemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707:SF0">
        <property type="entry name" value="PININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707">
        <property type="entry name" value="PINN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04696">
        <property type="entry name" value="Pinin_SDK_memA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Pinin/SDK/MemA protein" evidence="10">
        <location>
            <begin position="30"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="206"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="69"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW74730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="306" mass="34281" checksum="603A98DEFD12E4E6" modified="2014-03-19" version="1">MQDKDIPTGPAAMATGTKKRPRLDLNVESRERKRGKSIFGIVLGTLNKAKKEDIQRNSSEAGKKRQLIEQRLQDKIRKETDSVRRAEEAKKDKTIANRKEEELQLNDSIHKLRRTRLPLLSNFLSTSDDIPIDDSEPASTRAPLSLPPRSHPPPLFYLPVTLLPSQEAFLAKRKAEVKEAAETEWNTFRAGRTAGIEEIRTLRHRAAEEEARKKAEREANKQQVKDGDTGADVVSPRRDESHAVPSTEKRDADMDVDEPPAVTNGSEPVERADEGRNGAEKATAAEPERKDEPAPMQADDDDAVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JP35</accession>
    <name>W4JP35_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_455906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552689.1">
        <property type="nucleotide sequence ID" value="XM_009554394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JP35"/>
    <dbReference type="GeneID" id="20676677"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_455906"/>
    <dbReference type="HOGENOM" id="CLU_1378294_0_0_1"/>
    <dbReference type="InParanoid" id="W4JP35"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="198" mass="20660" checksum="35F1EB234B5060D9" modified="2014-03-19" version="1">MALNWDRETSVGALGAMKSHRVPRFRAICTRSLVNCRFEPHAKITRLGPDARSAASPTRQVPPLSPSSATSRLPAAGTGVATCVPFISVAERGSQKPAIGAQHRFWRASVFAAVRAMPASAIFGARALRVASSSAMPLIAGLSSPFGEGAAFRGSKGPATSVPSSAKLLWRDASVASAEIPLQHPNTLSSAFSPPRTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQ58</accession>
    <name>W4JQ58_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_481162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551961.1">
        <property type="nucleotide sequence ID" value="XM_009553666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQ58"/>
    <dbReference type="GeneID" id="20677957"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_481162"/>
    <dbReference type="HOGENOM" id="CLU_700316_0_0_1"/>
    <dbReference type="InParanoid" id="W4JQ58"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW75697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="43362" checksum="AC03FEE07E664695" modified="2014-03-19" version="1">MNTYNSSSRDNQCSRRQRSKDIAHDLDTFIVCRQIKLSISAQIQEVYFQNPNHLVAFSKIMAQLPWAHQDPSTLPSCACHPHDHDFGVASHRKKHKASVRYAGKDRDGHSALGDAKCEAPFSISCAISCGVGTFLLVEAVRGGERNARDVELRRTFLNLRSQDIENNPNTTRTSASPFVDDKFLSTSGPESSDASYQQPVTCSVPVSEVLNVQSDLLEVDLLSLGAMAYELIHGCKPTHGSKFLRDLRLQKDRVVFKSKETMDEPTQVSIYQSLLKDLIGHILLDVIQDSGLRSDPEVNCQNCQNSAQKAHQMLGAPMLSCTDSRDVRQTSWASTSTTTSSSDISDISAAIDASDSFVSVVLDEPAVPVTSTKTCSFASRSLARLSRFFLCRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQ99</accession>
    <name>W4JQ99_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_330024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551998.1">
        <property type="nucleotide sequence ID" value="XM_009553703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQ99"/>
    <dbReference type="GeneID" id="20671540"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_330024"/>
    <dbReference type="HOGENOM" id="CLU_906311_0_0_1"/>
    <dbReference type="InParanoid" id="W4JQ99"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="307" mass="35401" checksum="2D3B9E8158F82E14" modified="2014-03-19" version="1">MTMPHLEWTTPAEKSWLETRVRAEYTYQTDATRYNWSRGIARDFMDEFPREKRELKGRLESDEELEERWRKVETRVRTWIRNHHNRVLHGPTSPSILSPSRRTRTRTRAKSPRDFILKGDQLTVHKHSELNKLHREGKITKAQKMAQFGRFVSGRLALPEVKALCKAMADEFNQSRHQITASVESTDSLHIAQPPAPHPEAVAGPSFTHHFESLTVDRTVASESFNYSHEFLMLLNDDHIHYAEDLFPVEEQAQAADNVVLDHTYTYTFPTDMLPTLLNTSPTIPQPNSPSALLDDSHPNAENSLGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4JR32</accession>
    <name>W4JR32_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_331192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552757.1">
        <property type="nucleotide sequence ID" value="XM_009554462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JR32"/>
    <dbReference type="GeneID" id="20671638"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_331192"/>
    <dbReference type="eggNOG" id="KOG2787">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036244_3_1_1"/>
    <dbReference type="InParanoid" id="W4JR32"/>
    <dbReference type="OrthoDB" id="10257263at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031179">
        <property type="term" value="P:peptide modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04794">
        <property type="entry name" value="euk_LANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736">
        <property type="entry name" value="LANC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736:SF7">
        <property type="entry name" value="LANC-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158745">
        <property type="entry name" value="LanC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR607822-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW75326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="254" mass="26186" checksum="8FAD2A7046AFFFC0" modified="2014-03-19" version="1">MWRWHGKRYLGGAHGVAGILQIILHAPPALLYPHTAAISSTLAYLVSLQDRTGNWPSKAPARHDDQDRENDLVQWCHGAPGILPLLATALALSEPQPQPDPQPASSSHLPAPALSLPPALRPALLSALAHGAALVSARGLLRKGPGLCHGAAGNACALFCASDALGRAGAGHRAAAASAMAGGVRLLLRCVELRGTPAFGRPDRPWSLYEGEAGLCAVLAEAVERVGSVLDGAGAGAVREYGSGLVGYCDLVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JR94</accession>
    <name>W4JR94_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_456159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553006.1">
        <property type="nucleotide sequence ID" value="XM_009554711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JR94"/>
    <dbReference type="STRING" id="747525.W4JR94"/>
    <dbReference type="GeneID" id="20676703"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_456159"/>
    <dbReference type="HOGENOM" id="CLU_1713521_0_0_1"/>
    <dbReference type="InParanoid" id="W4JR94"/>
    <dbReference type="OrthoDB" id="343070at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW75610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="153" mass="16554" checksum="80B8D81942F9861A" modified="2014-03-19" version="1">MPTRALHARYNPAGLQGCILALKMIGGGFYKVRGELGVFDSELGTHPAVVRAMAEPPAIYRSSPIRPHHPSLLLLPLPSLPHMPNLRPWAMQAYTKERDTSKSMLARTRDGASAEPYVNGTGSWIGSRGVNGAAESVTSELQEVVPELELAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRH3</accession>
    <name>W4JRH3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_119296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552287.1">
        <property type="nucleotide sequence ID" value="XM_009553992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRH3"/>
    <dbReference type="GeneID" id="20666642"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_119296"/>
    <dbReference type="eggNOG" id="ENOG502RC55">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035509_7_0_1"/>
    <dbReference type="InParanoid" id="W4JRH3"/>
    <dbReference type="OrthoDB" id="2686513at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="8"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW76064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="285" mass="32518" checksum="CFD9F052241A265C" modified="2014-03-19" version="1">MQKYVPFILYYDHLMTLSEEITWIWSRPRARSSLLFFLNRYVPLVGHIAVLVYTFGGFTICDKFPGIHSIPSLPDYVQPNSRGQFYSLADTAHYYHLLVCTSNAWGEQWSAITAYTVTSAELAHDRHNHISFPKLSFVAYCLAAPWEMHIVFDVTVFILTTVKWSQHRRDSLAHLDTCEKWSGAMYFCAMGLAELANIFTFYDPLRGTLSTFATCISVTMMSRLILNLHGTSSRLPSSTQATESIVFASRRDTMMHPDDADDDVVHDIGSHRLEHLSQEDVNVCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSL2</accession>
    <name>W4JSL2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_480662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551425.1">
        <property type="nucleotide sequence ID" value="XM_009553130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSL2"/>
    <dbReference type="GeneID" id="20677927"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_480662"/>
    <dbReference type="eggNOG" id="ENOG502SNIP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035509_1_1_1"/>
    <dbReference type="InParanoid" id="W4JSL2"/>
    <dbReference type="OrthoDB" id="3251775at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="18"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW76533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="213" mass="24063" checksum="7A32AA306237AA40" modified="2014-03-19" version="1" fragment="single">MDAEKLISALKNVNATRYLSAAGLVALLYDHLLTINDEIELIWRARNTLPKTLFLINRYLVPILMLVTIYPLAALSPGPSDAVCKTWFTIAIILGMISIANGHFIVLLRLWILWNKQPRLVCASLAVFVISQLGTFAMVTWVAVQMRPVLEYNATLRICSLTRKVHIEGLWAPGVFFEVVVFVTVCWNAMARPRESDQALTRVLYRDGLVFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTE9</accession>
    <name>W4JTE9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_455249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551663.1">
        <property type="nucleotide sequence ID" value="XM_009553368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTE9"/>
    <dbReference type="GeneID" id="20676601"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_455249"/>
    <dbReference type="HOGENOM" id="CLU_2049973_0_0_1"/>
    <dbReference type="InParanoid" id="W4JTE9"/>
    <dbReference type="OrthoDB" id="3022331at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="120" mass="12839" checksum="35950D65F03318EA" modified="2014-03-19" version="1">MPAYSGEEAQVVVSHTPFMDGSFPAQGFTHDGASPSIATSSEASQLLLPSTSTYATEIFGLTSPTNGQLGSDYEMTHDSLWSNLPSGFELEDWDTFIFGFGQIQPDVHPNGHSNGTVRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUU2</accession>
    <name>W4JUU2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BPL/LPL catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_147935</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the biotin--protein ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550790.1">
        <property type="nucleotide sequence ID" value="XM_009552495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUU2"/>
    <dbReference type="STRING" id="747525.W4JUU2"/>
    <dbReference type="GeneID" id="20667242"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_147935"/>
    <dbReference type="eggNOG" id="KOG1536">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051096_2_1_1"/>
    <dbReference type="InParanoid" id="W4JUU2"/>
    <dbReference type="OrthoDB" id="10250105at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin--[biotin carboxyl-carrier protein] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835">
        <property type="entry name" value="BIOTIN PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835:SF5">
        <property type="entry name" value="BIOTIN--PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="38"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW77259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="323" mass="34899" checksum="AE9038397CB79576" modified="2014-03-19" version="1">MVLAPGELPSNKITPLFDVRGYFDALREARKHEEPPTSEKARDEEGWGLGEALLYGEVITSTQTMLDKNPHLLNILPSPLLSLATHQLAGRGRGANTWLSPLGCLQFSLLLHVPLSALPAARLVFVQYLFALAVVRACRDPRGLGGDRGAGVRLKWPNDIYIEMRGGERKKVGGILVHTSFSGGKVDLIVGCGLNVATPAPLASLAFLATPGGAPSPEMMLALIMTKFESMWEEFIRARGSWAQFADAYLDAWMHSDQLVTLTTVTPPRAVRIVGITPDYGLLRTLPERGAWSVGGSADTGFIDLQPDGNSFDLMAGLIKAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4JV39</accession>
    <name>W4JV39_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">A-kinase anchor protein 7-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_147887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550911.1">
        <property type="nucleotide sequence ID" value="XM_009552616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JV39"/>
    <dbReference type="STRING" id="747525.W4JV39"/>
    <dbReference type="GeneID" id="20667236"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_147887"/>
    <dbReference type="eggNOG" id="KOG2814">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044606_1_0_1"/>
    <dbReference type="InParanoid" id="W4JV39"/>
    <dbReference type="OrthoDB" id="277832at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009210">
        <property type="entry name" value="ASCC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360:SF1">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A-kinase anchor protein 7-like phosphoesterase" evidence="2">
        <location>
            <begin position="45"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW77402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="248" mass="26466" checksum="3F972C83D83F9EE5" modified="2014-03-19" version="1" fragment="single">MFTTGSASRHAQQMPRPKPPKARGAPSTSSPATGPSQRPANPKLTHFISLPIGHHASLRASMTGFTSALLQGAPAVAGLDRTIVIPARRLHLTLGVMSLDQPGSARANAPPPTLGAARALLEALLPRVLQMLHGQRLRVDLERMDVLQPERGDASRAHVLFVGPVLGGEDGRRLRSVCEMVRGEFIASGLMVDDHRPLKLHCTVLNTTYRKPRPRGARQPFSYADILQSTAFRAIAATQGSGIGAPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JW84</accession>
    <name>W4JW84_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_105511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550859.1">
        <property type="nucleotide sequence ID" value="XM_009552564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JW84"/>
    <dbReference type="STRING" id="747525.W4JW84"/>
    <dbReference type="GeneID" id="20666072"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_105511"/>
    <dbReference type="HOGENOM" id="CLU_1133705_0_0_1"/>
    <dbReference type="InParanoid" id="W4JW84"/>
    <dbReference type="OrthoDB" id="3269405at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW77340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="245" mass="26650" checksum="4B650CE9FD4DC78C" modified="2014-03-19" version="1">MLNYNVHMGIDLLLDGYLARCFGSGAAERFFRSFPGVPPHPEPIPATYDEGSCAFYLQNGSSYGLRDPLDYAVNNTRGVVVHQTAWTSPALFGAEREQLTASRAHLAPTKFFVNVDGSIGLPISDAIENRGYTLKGCDAAMSFGASFPPYITLHIQWPGYPSWTTQLSTTDDGRGGGITLAECARRLGLAVDAFLVQHVAKRSSKSEWRIGVGGITRGDVVLIGLVEVYKGLWMPVLQLCRHIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWI4</accession>
    <name>W4JWI4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Double-strand break repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HETIRDRAFT_327725</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16 18">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550781.1">
        <property type="nucleotide sequence ID" value="XM_009552486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWI4"/>
    <dbReference type="FunCoup" id="W4JWI4">
        <property type="interactions" value="642"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JWI4"/>
    <dbReference type="GeneID" id="20671356"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_327725"/>
    <dbReference type="eggNOG" id="KOG2310">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009535_3_4_1"/>
    <dbReference type="InParanoid" id="W4JWI4"/>
    <dbReference type="OrthoDB" id="30417at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000011">
        <property type="entry name" value="Double-strand break repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.110">
        <property type="entry name" value="Mre11, capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003701">
        <property type="entry name" value="Mre11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038487">
        <property type="entry name" value="Mre11_capping_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00583">
        <property type="entry name" value="mre11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000882">
        <property type="entry name" value="DSB_repair_MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 16 18" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16 18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 16 18" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 16 18" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 16 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 16 18" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 16 18" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16 18" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14 16 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="19">
        <location>
            <begin position="312"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000882-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ETW77246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="600" mass="67359" checksum="36B9581506D5A460" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W4JX14</accession>
    <name>W4JX14_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphotransferase</fullName>
            <ecNumber evidence="11">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_389219</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="11"/>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551104.1">
        <property type="nucleotide sequence ID" value="XM_009552809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JX14"/>
    <dbReference type="FunCoup" id="W4JX14">
        <property type="interactions" value="227"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JX14"/>
    <dbReference type="GeneID" id="20672396"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_389219"/>
    <dbReference type="eggNOG" id="KOG1369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014393_5_2_1"/>
    <dbReference type="InParanoid" id="W4JX14"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24087">
        <property type="entry name" value="ASKHA_NBD_HK1-2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000156">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000009">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="12">
        <location>
            <begin position="43"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="13">
        <location>
            <begin position="245"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW77625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="496" mass="55028" checksum="69BFEA3E5D75B83E" modified="2014-03-19" version="1">MPASRRGSGSVTLPTGQVLAIHTRTQDEEDLPHATKKTMADHLRKYESLFTLTPQRMRMIVEAFKDTLEIGLEKPGQTVPMIPTFVFGWPTGTETGDYLALDLGGTNLRVCLVTLQGEGKFEITQSKYRLTEEQKQEDGQKLFDFCAECLKTFVTTNLDEGTIKEGERLPLGFTFSYPCTQERIDQGVLIRWTKGFGAADTEGHDVAEMFKRSLEKHDVPVELTALINDTTGTLIASHYVNPRTKIAVIFGTGCNAAYMERIGGIPKIKNLGCDDDDEMAINCEWGAFDSFEHEHLPRTKYDLTIDESSNKPGEQAFEKLISGRYLGEILRLVICELIDDGVLFLGQNTYKIEIAYALDTAFLSLMESDPTEELLMIIGIFSHFFALETTLAERQFFRALAKLVGRRAARLSACGIAAIVSKMGYLEEGCSVGADGSLYNKYPGFADRVHEGLQDIFGDKGRNIITHHAEDGSGVGSAIIAAMTKIRKDKGQYLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4JX55</accession>
    <name>W4JX55_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_454097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550043.1">
        <property type="nucleotide sequence ID" value="XM_009551748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JX55"/>
    <dbReference type="GeneID" id="20676464"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_454097"/>
    <dbReference type="HOGENOM" id="CLU_052689_1_0_1"/>
    <dbReference type="InParanoid" id="W4JX55"/>
    <dbReference type="OrthoDB" id="3226623at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="404" mass="45357" checksum="EC52D9B766E38368" modified="2014-03-19" version="1">MNHPIITRSDSLLSTAPSVHFPRVREEGSSRLHDLPNELWLQIFEWATFDPGFPNSLETAFSDLHYHLNLEWHHIDMSLETKSSLVCVCRRWYALATPLLYQAVVVMNENVHSLFRTLKQATEIPNGIMLGSLVRRLDVCLEREFDLPELGEIFGYISHLRILISASIYENDAKGAFEIAASRCSPTLQELVADVSSPLFSGFLERLPNLRTLHHSDFCPYVLPPLPNLRSMASDNCHSVCSAHFSEDATMPELEATTNISKPVFKALAENCPHLTHLGFHFPPTEKWNDEPDEPDEPIQNEVQEFGYHEDTSDASDDGQPGIATDSPPPIDSPPPAVPKYKAGDGANAPSLQVVQLLDRDMVYGVRRKYSRDLARALETLPGVRVEDHEGIDLRHLLPRLAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4JX82</accession>
    <name>W4JX82_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="14">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HETIRDRAFT_327377</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="14"/>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550991.1">
        <property type="nucleotide sequence ID" value="XM_009552696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JX82"/>
    <dbReference type="FunCoup" id="W4JX82">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JX82"/>
    <dbReference type="GeneID" id="20671324"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_327377"/>
    <dbReference type="eggNOG" id="KOG2124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007676_0_0_1"/>
    <dbReference type="InParanoid" id="W4JX82"/>
    <dbReference type="OrthoDB" id="2748310at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000015">
        <property type="entry name" value="GPI ethanolamine phosphate transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="519"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="558"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="583"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="613"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="637"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="696"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="745"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="805"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="843"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="877"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="910"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="15">
        <location>
            <begin position="449"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETW77491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="947" mass="105058" checksum="D7540269D4FE869E" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXQ3</accession>
    <name>W4JXQ3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_388372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550282.1">
        <property type="nucleotide sequence ID" value="XM_009551987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXQ3"/>
    <dbReference type="STRING" id="747525.W4JXQ3"/>
    <dbReference type="GeneID" id="20672365"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_388372"/>
    <dbReference type="eggNOG" id="KOG0703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023062_1_4_1"/>
    <dbReference type="InParanoid" id="W4JXQ3"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08839">
        <property type="entry name" value="ArfGap_SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000010">
        <property type="entry name" value="Stromal membrane-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044732">
        <property type="entry name" value="ArfGAP_SMAP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF14">
        <property type="entry name" value="ARF-GAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="2">
        <location>
            <begin position="10"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW78303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="132" mass="15412" checksum="CBA08F7A67CB9FAD" modified="2014-03-19" version="1" fragment="single">MSRQDRATTERHTKILRELVKRPENKTCSDCKHNDPRWASWNLGVFLCIRCSGIHRGMGTHISKVKSIDLDTWTPEQMESITKWGNRRANLYWEAHLKSGHVPPDHKMESFIRSKYESRRWAMDGPPPSDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXT9</accession>
    <name>W4JXT9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_244431</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549917.1">
        <property type="nucleotide sequence ID" value="XM_009551622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXT9"/>
    <dbReference type="STRING" id="747525.W4JXT9"/>
    <dbReference type="GeneID" id="20669051"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_244431"/>
    <dbReference type="eggNOG" id="KOG1744">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075666_3_1_1"/>
    <dbReference type="InParanoid" id="W4JXT9"/>
    <dbReference type="OrthoDB" id="10254238at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000016">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW77900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="89" mass="9861" checksum="2ECF2A1F6D12AB73" modified="2014-03-19" version="1" fragment="single">TRKETYSSYIYKVLKQVHPDTGISNKAMAILNSFVNDIFERIATEASKLAAYSKKSTISSREIQTAVRLILPGELSKHAISEGTKSVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYI2</accession>
    <name>W4JYI2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_103921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ETW78509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548846.1">
        <property type="nucleotide sequence ID" value="XM_009550551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYI2"/>
    <dbReference type="GeneID" id="20665954"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_103921"/>
    <dbReference type="HOGENOM" id="CLU_1886026_0_0_1"/>
    <dbReference type="InParanoid" id="W4JYI2"/>
    <dbReference type="OrthoDB" id="6512771at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="135" mass="15417" checksum="C43D2BA5AA774EE2" modified="2014-03-19" version="1">MSVPPLPPNEGVVEVWMPALAPLDDDEDDLYMTPPPETVHNENANNSEDEDDLYMTPPPENLNGVDSRFPVPLDLDIDINPALIPLILGHEHEQERVKYCWTTFHLKCVRLWAAKSVKDIKEAWCRRSESGRKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYR7</accession>
    <name>W4JYR7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_441479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550016.1">
        <property type="nucleotide sequence ID" value="XM_009551721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYR7"/>
    <dbReference type="GeneID" id="20675369"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_441479"/>
    <dbReference type="HOGENOM" id="CLU_1547787_0_0_1"/>
    <dbReference type="InParanoid" id="W4JYR7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="173" mass="19362" checksum="BA7B0CF4A0BE2FDD" modified="2014-03-19" version="1">MPQPKSMTNPSLSPSTSREHFQGPPPSSGPQLQLVPLIGIPRRRSRTSSNWHRHRCTDALCTRHPPARQRTPRNLTPQPSRSRRRADERVTGLTRAKPGPAQRGRAMSRCDRSQPLPPPLSLFDDVSAPIPARRAPSLLPQPTSLQNPRQAAVAIRRNPPDWAQETLLQCLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZR6</accession>
    <name>W4JZR6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_478419</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit APL4 and beta-type subunit APL2), a medium adaptin (mu-type subunit APM1) and a small adaptin (sigma-type subunit APS1). AP-1 interacts with clathrin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009551042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZR6"/>
    <dbReference type="FunCoup" id="W4JZR6">
        <property type="interactions" value="220"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JZR6"/>
    <dbReference type="GeneID" id="20677815"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_478419"/>
    <dbReference type="eggNOG" id="KOG1062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003824_0_0_1"/>
    <dbReference type="InParanoid" id="W4JZR6"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000030">
        <property type="entry name" value="AP-1 complex subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="12">
        <location>
            <begin position="712"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="677"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="691"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW79068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="833" mass="90877" checksum="7A2A67186510AE22" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZY5</accession>
    <name>W4JZY5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HETIRDRAFT_460086</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP = N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hydrogencarbonate + acetyl-CoA + ATP = malonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11308"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549397.1">
        <property type="nucleotide sequence ID" value="XM_009551102.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="W4JZY5">
        <property type="interactions" value="255"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JZY5"/>
    <dbReference type="GeneID" id="20677042"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_460086"/>
    <dbReference type="eggNOG" id="KOG0368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_5_2_1"/>
    <dbReference type="InParanoid" id="W4JZY5"/>
    <dbReference type="OrthoDB" id="14612at2759"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.460.10:FF:000001">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000005">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000010">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.460.10">
        <property type="entry name" value="Biotin dependent carboxylase carboxyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1770.10">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049074">
        <property type="entry name" value="ACCA_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08326">
        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21385">
        <property type="entry name" value="ACCA_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0092">Biotin</keyword>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="17">
        <location>
            <begin position="69"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="16">
        <location>
            <begin position="221"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="15">
        <location>
            <begin position="704"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="18">
        <location>
            <begin position="1506"/>
            <end position="1844"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="19">
        <location>
            <begin position="1848"/>
            <end position="2163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ETW79133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="2267" mass="251838" checksum="9B64050E0629EC58" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1G5</accession>
    <name>W4K1G5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Crinkler effector protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_386139</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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        </citation>
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        </source>
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        </subcellularLocation>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_386139"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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            <begin position="9"/>
            <end position="107"/>
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    </feature>
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    </evidence>
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</entry>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="van Diepen L.T."/>
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                <person name="Duplessis S."/>
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                <person name="Fossdal C.G."/>
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                <person name="James T.Y."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
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                <person name="Cullen D."/>
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                <person name="van Diepen L.T."/>
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                <person name="Fossdal C.G."/>
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                <person name="Lin Y.C."/>
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    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
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                <person name="James T.Y."/>
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                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="Google" id="ProtNLM"/>
        </source>
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</entry>
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    <accession>W4K2S4</accession>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
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                <person name="Velez H."/>
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                <person name="Yakovlev I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW80117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
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</entry>
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    <accession>W4K371</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
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            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
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                <person name="Himmelstrand K."/>
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                <person name="Hogberg N."/>
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                <person name="Kues U."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="20670913"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_322848"/>
    <dbReference type="HOGENOM" id="CLU_163763_0_0_1"/>
    <dbReference type="InParanoid" id="W4K371"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="88" mass="9660" checksum="8418007D7BEC0C28" modified="2014-03-19" version="1" fragment="single">VKCGQTDPSAAECPLVGCSQSGRDQPYLVIVGIFGTCLVLFGVSSKLPEYLFWTLAQVHAHHYFSLHIPSYLTPQHILYPPAMLDTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4K399</accession>
    <name>W4K399_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_440286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547066.1">
        <property type="nucleotide sequence ID" value="XM_009548771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K399"/>
    <dbReference type="GeneID" id="20675248"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_440286"/>
    <dbReference type="HOGENOM" id="CLU_2441130_0_0_1"/>
    <dbReference type="InParanoid" id="W4K399"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="90" mass="9145" checksum="F7A943B898765600" modified="2014-03-19" version="1">MRALYASTQHRREDASAHSRGPLTSLPAHASRRPPPPPVAVLEAVHRGSPVQGSPAKAVQSVPPHLCSGSGSRRASKSADGALRAGGGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3B4</accession>
    <name>W4K3B4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_103588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548365.1">
        <property type="nucleotide sequence ID" value="XM_009550070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3B4"/>
    <dbReference type="STRING" id="747525.W4K3B4"/>
    <dbReference type="GeneID" id="20665918"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_103588"/>
    <dbReference type="eggNOG" id="ENOG502RCUR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_454961_0_0_1"/>
    <dbReference type="InParanoid" id="W4K3B4"/>
    <dbReference type="OrthoDB" id="3242376at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="23"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="394"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW79820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="600" mass="67132" checksum="2B8780CF0549A62B" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3B5</accession>
    <name>W4K3B5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD dependent epimerase/dehydratase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nmra1</name>
        <name evidence="5" type="ORF">HETIRDRAFT_151380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548145.1">
        <property type="nucleotide sequence ID" value="XM_009549850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3B5"/>
    <dbReference type="STRING" id="747525.W4K3B5"/>
    <dbReference type="GeneID" id="20667387"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_151380"/>
    <dbReference type="eggNOG" id="ENOG502S1FN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044876_6_1_1"/>
    <dbReference type="InParanoid" id="W4K3B5"/>
    <dbReference type="OrthoDB" id="5283654at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="11"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW79571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="312" mass="33657" checksum="8B0138BB3461EC81" modified="2014-03-19" version="1">MSTYNNFAVAGVGNVGKFIVEELLNQKAAGKAHEVIILTRKGSNNEAVTELSSRGAKVVAVDYDSVSALASALTGVDVVISALGYAAIFAQQLNLAAASKIAKVGLFIPSQYGLPGRAGIPSEKELKEKLDGVGMSVFLDGALADILFKYADYANLILEKGEATIPGDGTALISFTDRRDVARYVAYVLTTLPPTRLANREFRIEGQRASLKAIVDEYQARTEKTLKVTYLPTEDLENALKKNSNDILSVIRLAWATGKGIVGEESELANSEFPEWKPKTVIDILLVKESARSSNWASLGPVEYWTRRGQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3M5</accession>
    <name>W4K3M5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_319485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547092.1">
        <property type="nucleotide sequence ID" value="XM_009548797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3M5"/>
    <dbReference type="FunCoup" id="W4K3M5">
        <property type="interactions" value="922"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K3M5"/>
    <dbReference type="GeneID" id="20670600"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_319485"/>
    <dbReference type="eggNOG" id="KOG1243">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010392_1_0_1"/>
    <dbReference type="InParanoid" id="W4K3M5"/>
    <dbReference type="OrthoDB" id="447103at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF3">
        <property type="entry name" value="N-TERMINAL KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="25"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW80329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="710" mass="77684" checksum="5E7CD0CE604F7B58" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3X1</accession>
    <name>W4K3X1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_477631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548564.1">
        <property type="nucleotide sequence ID" value="XM_009550269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3X1"/>
    <dbReference type="GeneID" id="20677765"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_477631"/>
    <dbReference type="HOGENOM" id="CLU_1890704_0_0_1"/>
    <dbReference type="InParanoid" id="W4K3X1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="135" mass="14663" checksum="056A0D926213D36E" modified="2014-03-19" version="1" fragment="single">MPYRAPMHHLQRSVLHHARRASGSVIDRGARAQSARNGATRLAAVGDNACGSMYAHPAPTASGKGGDACWRPRTFMPISRPKISRAELSPAAAPRQPGYYQPNSSARLPNSVGARAHRSSARERRIVSDQTDRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3Y4</accession>
    <name>W4K3Y4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Lysophospholipase</fullName>
            <ecNumber evidence="2 9">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_384983</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="2 9"/>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547200.1">
        <property type="nucleotide sequence ID" value="XM_009548905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3Y4"/>
    <dbReference type="FunCoup" id="W4K3Y4">
        <property type="interactions" value="206"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K3Y4"/>
    <dbReference type="GeneID" id="20672227"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_384983"/>
    <dbReference type="eggNOG" id="KOG1325">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014602_1_0_1"/>
    <dbReference type="InParanoid" id="W4K3Y4"/>
    <dbReference type="OrthoDB" id="4084751at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF33">
        <property type="entry name" value="LYSOPHOSPHOLIPASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 8 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005150317" description="Lysophospholipase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
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        <location>
            <begin position="30"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="652"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="688"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW80449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="716" mass="77816" checksum="BADBF5593189ACDA" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4S2</accession>
    <name>W4K4S2_HETIT</name>
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        </recommendedName>
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            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="44"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW80808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="203" mass="22660" checksum="3429C972D363DD96" modified="2014-03-19" version="1">MAAVPTLPKDVSKLGQEIKLFGKWETQDVEVKDISLTDYIQIRHAVYLPHTAGRYAKKQFKKAQMPIVERLVDSLMMKGRNNGKKLMAVRIVAHAFEIIHLLTDQNPIQVLVDAIVNTGPREDSTRIGSQGTVRRQAVDVSPLRRVNQAISLLTIGTRESAFRNVKSIAECLADELINAAKGSSNSYAIKKKDELERVAKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4Z5</accession>
    <name>W4K4Z5_HETIT</name>
    <protein>
        <submittedName>
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    <gene>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="W4K4Z5"/>
    <dbReference type="STRING" id="747525.W4K4Z5"/>
    <dbReference type="GeneID" id="20667523"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_154793"/>
    <dbReference type="eggNOG" id="KOG0101">
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    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW80440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="595" mass="66522" checksum="D72BEE1AAE63DD35" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5G6</accession>
    <name>W4K5G6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_427876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547748.1">
        <property type="nucleotide sequence ID" value="XM_009549453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5G6"/>
    <dbReference type="GeneID" id="20674237"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_427876"/>
    <dbReference type="HOGENOM" id="CLU_555540_0_0_1"/>
    <dbReference type="InParanoid" id="W4K5G6"/>
    <dbReference type="OrthoDB" id="3235325at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="491" mass="50705" checksum="EF9C192FA2ADD2E6" modified="2014-03-19" version="1">MYVEDKDGNCIDGHRAREIRAVVTQFWLWLKKVNQSPRTWTQLDLKLSDLYRLEMAYRFPELQLCEGGWKADMIAIHSYSQWYGRSVVQGPRRVKKEAPNQDMLVAQLTSAKRQNEDPDRLSSEPPKKPRLDPPQHSTVAAKDGRILAPDNEVAHAPDGKAIATDGDSIGLDVGATAMDGGGITLGAETAITSVGGIVEDAENTAQGDEGSAQRDTIANVLSADSILPASPTSQPHGSQPVPPRPRIVTKPMNPLSKLFRGAPTRPLPTLDINSLGPSDAAPAANTSSVLSTTRDATTSGSAPVFAGPGVTTGSADTATDAAAATTTITTTTTTTTAAAAAATLAAATLAAVAPAAVAPAAIAPAAVALAAVAPAAPAITTAAATTATAPTAPAAAPAAPAAPAPAPAVPAASASSASSSKAPSRKKGVGNGVLRIGKQLVARNICARQWKEQFPKGTTNEFKVYWSSLSPDELAVYDRLEQEQKMNIVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5K1</accession>
    <name>W4K5K1_HETIT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_102095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547719.1">
        <property type="nucleotide sequence ID" value="XM_009549424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5K1"/>
    <dbReference type="GeneID" id="20665823"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_102095"/>
    <dbReference type="HOGENOM" id="CLU_1586696_0_0_1"/>
    <dbReference type="InParanoid" id="W4K5K1"/>
    <dbReference type="OrthoDB" id="3018737at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="168" mass="18628" checksum="39BB9BDF9FB55808" modified="2014-03-19" version="1">MTGPLLRFDFPSSPLLSSSSSETVFSSAVLNRMPTLPLPHSAALGSTTSLSTALTEFSLRTPIHLVRAVPHITITRPASDRWEDKPLPPLPSPSPAPKGIPFNLVMSVLEFLERNDRDMASELQRVRRNIQEAEREISEWKQERRLRDAEFADRQRGCGGRSASSAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5N2</accession>
    <name>W4K5N2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">PIG-U-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_434894</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGU family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547754.1">
        <property type="nucleotide sequence ID" value="XM_009549459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5N2"/>
    <dbReference type="FunCoup" id="W4K5N2">
        <property type="interactions" value="476"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K5N2"/>
    <dbReference type="GeneID" id="20674781"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_434894"/>
    <dbReference type="eggNOG" id="KOG2552">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030193_0_0_1"/>
    <dbReference type="InParanoid" id="W4K5N2"/>
    <dbReference type="OrthoDB" id="549017at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009600">
        <property type="entry name" value="PIG-U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW81074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="44942" checksum="AEDA8DF9E2D46FAC" modified="2014-03-19" version="1">MSFGLVFPALVAARLILQLSPLSSLLKHDSQLSSPLTSYSRLQEGIYLFRNGIDPYSGGTFRHSPLYLSLFSIVLLESNALSAVLWTLADAIGAWALVQIWRARSRTSKGRKDSVIAAVYLLNPYIFLPSLAFSTSTFDNAFQLLSLMFASQGRISESLLTLALLSHLSLPSILLLPPTVLLLLSDPTSHLASPKPFAQKLRKAIPLTTEFLAYFSVLIFASTLPSAGWGWVRNTWGAGFLLPDLTPNPGLWWYFFTEMFDHFRPFFLMVFNVHLLIYVAPICIKFQHDPLYATFLLIGVLALFKPYPTLSDPGLFISLISLFPETYAYFRHPIVTTLLHLHASLLLPLFHHLWVAAGTGNANFFYASTLVFGIANGAALIDCVWAGLRIALGEEKEGWVVIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5U7</accession>
    <name>W4K5U7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 monooxygenase 93</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cpm93</name>
        <name evidence="11" type="ORF">HETIRDRAFT_115762</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547173.1">
        <property type="nucleotide sequence ID" value="XM_009548878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5U7"/>
    <dbReference type="STRING" id="747525.W4K5U7"/>
    <dbReference type="GeneID" id="20666500"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_115762"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_3_1"/>
    <dbReference type="InParanoid" id="W4K5U7"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW80416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="510" mass="58203" checksum="E3E6FBF67FEA7C00" modified="2014-03-19" version="1">MTLHLFSLMRDYNDLFFAVAIAALTFFLLMSRTRGLPLPPGPRASWWLGTVHLPEILPWLTVAKWRETYGTQFLKGDIIYISQVGNSILYVNSAKVASDLLDKRSVNYSSRPPSPMVRDLMGWRWAFPSMPYGPTWRKYRALFQKQFQPNSSRYQPIQAKEVHGLLRNLARSPEKFHYHIQRIEEEGDIYVTLSERAIASALNAGVFGTYLVDYIPLLRYVPDWLPGAKFKRQAKEWKKLVDDMVDQPFEMTKERMASGTAEPCFTTLELEDSADRANDAEYATMIKSVAAISYAAGTDTTVSAIETFFLAMMLYPEVQRKAQAHLDKVIGVDRLPRFSDRQDLSYIDCIIWEALRWKPTVPMGLSHTSVKDDIYEGYSIPKGTTIFPNIWAIMHDEKTYPDPSAFRPERFEDRKRNLELGINPLPEVVFGYGRRACPGRWLAFDTLWITVASVLAVYNISKAVDDGGAVIEPDTEYTTGIVSRPKPFRVSLVPRSDAALELIRQTGEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4K617</accession>
    <name>W4K617_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_61600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546961.1">
        <property type="nucleotide sequence ID" value="XM_009548666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K617"/>
    <dbReference type="STRING" id="747525.W4K617"/>
    <dbReference type="GeneID" id="20678563"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_61600"/>
    <dbReference type="eggNOG" id="ENOG502QUM3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016972_1_1_1"/>
    <dbReference type="InParanoid" id="W4K617"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845243" evidence="1">
        <location>
            <begin position="26"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="42"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW80501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="329" mass="35568" checksum="D9B3606E47D54A3F" modified="2014-03-19" version="1">MRTGYALRLLLLALALAQDRAGVDAQTQYVLKDKFVGRDFLDAWTWETMDDPTHGRVNYVDQRTALQKNLSYATDAKFVMRADSWTRVGGGPRGRDSVRITSRGAYGDSLVVLDVAHMPAGCATWPAFWTLSQRGPWPHGGEIDIIEGVNEATANLVSLHTAPDCTMPQQRAQTGTVISTDCSGLANSNQGCGTQMTQAESYGAPFNAAGGGWYAMQRARGRGVRVWFWGRNDQGVPVEVRAGAGLVESVEGWGMPGADGAEGTCGFDEHFDDHVAVFDLTFCGDWAGSAWSSSGCGQGTCEDFVNNNPAAFAESYWEINSLRVYTPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4K623</accession>
    <name>W4K623_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_445428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547885.1">
        <property type="nucleotide sequence ID" value="XM_009549590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K623"/>
    <dbReference type="GeneID" id="20675627"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_445428"/>
    <dbReference type="eggNOG" id="ENOG502SZ87">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_278490_0_0_1"/>
    <dbReference type="InParanoid" id="W4K623"/>
    <dbReference type="OrthoDB" id="3184410at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="746"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
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        </location>
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            <end position="852"/>
        </location>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="ETW81224.1"/>
        </source>
    </evidence>
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</entry>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
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                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
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                <person name="Rouze P."/>
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                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="747525.W4K779"/>
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    </dbReference>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
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</entry>
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    <accession>W4K838</accession>
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        <submittedName>
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        </submittedName>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
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                <person name="Broberg A."/>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
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                <person name="Hansson D."/>
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                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
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                <person name="Raffaello T."/>
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                <person name="Stahlberg J."/>
                <person name="Velez H."/>
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                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
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    <dbReference type="InParanoid" id="W4K838"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="51" mass="5655" checksum="DF604ACC543B54FA" modified="2014-03-19" version="1">MGDEAERPYNTNSSSQILPFTSTTDFASSSAFPVLARSRFFHTSAPMDHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4K896</accession>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
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                <person name="Velez H."/>
                <person name="de Vries R.P."/>
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                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009547580.1"/>
    </dbReference>
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    <dbReference type="STRING" id="747525.W4K896"/>
    <dbReference type="GeneID" id="20678556"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_61404"/>
    <dbReference type="eggNOG" id="KOG2565">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019414_0_2_1"/>
    <dbReference type="InParanoid" id="W4K896"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="5">
        <location>
            <begin position="5"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW82018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="401" mass="45309" checksum="26E9C50C5230A8B6" modified="2014-03-19" version="1">MSTATPFKIAIPDSDIAALKQKLDLVRFPDELDDAGREYGVPLADLKRLVARWKDEYDWRKHEAELNELPMFTRGIEVDGFGTLDIHYVHQESDVEGAISLLFVHGWPGSFIEVQKILPLLTASSAEHPSFHVVGLGLPGYGFSEAPKKKGFAAKQFAEVGHKLMLALGYDEYVTQGGDWGSLITRVMSNLYGPKHVKAWHTNMPTSFPPRLFSHPLQYIKHLVLPYTAEERRRLTRASWFAQQGRGYFEEHATQPQTIGYALADSPTALLAWIYEKLVNWTDKYEWDDDEVLTWISIYWFSRAGPAASVRIYYETRKSGERLNPPRTKVPLGISYFPQELALGPNTWIKTIGNLVYESAIHEKGGHFAAHERPEDLAGDLRKMFGRGGPAYGLVKGKNGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8A2</accession>
    <name>W4K8A2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_318450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546573.1">
        <property type="nucleotide sequence ID" value="XM_009548278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8A2"/>
    <dbReference type="STRING" id="747525.W4K8A2"/>
    <dbReference type="GeneID" id="20670514"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_318450"/>
    <dbReference type="eggNOG" id="ENOG502SRCU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_816509_0_0_1"/>
    <dbReference type="InParanoid" id="W4K8A2"/>
    <dbReference type="OrthoDB" id="3260792at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="38851" checksum="813F3AA363FBEED8" modified="2014-03-19" version="1">MSRVFLEEDIATSPTASSSNLNTSEGMNRFSEPDDVASADQDSSTFGYPLQRMVPVESWDISTEDLSSEYDHDAYHQMSRPQSDSSSTSTFHHVDFEAVIDEYIKQCPTEDGRDLPFISSPINNPDHLSYSLTLRRIPTTSPEYLIVQYLTSNEIHQDPWNPAPRVLYKTERDGNHILCFERLSEYDQPPFQNIANVIDFIRQTLEGLSFLHKHKITHLGYNDPRGFMMDIGHSLPQNFDRTRFRVRYHRVNFAQAQKLNGDISIRSGPFLEDVRECGMMFQTVLSDVPKIDSKLKSLSKAMTGGEFGAEDSRKLFTALFQSVDYLMYDVPLFTPARTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8U7</accession>
    <name>W4K8U7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutathione synthetase</fullName>
            <shortName evidence="10">GSH-S</shortName>
            <ecNumber evidence="10">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">GS1</name>
        <name evidence="15" type="ORF">HETIRDRAFT_61272</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10 12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="10"/>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545865.1">
        <property type="nucleotide sequence ID" value="XM_009547570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8U7"/>
    <dbReference type="FunCoup" id="W4K8U7">
        <property type="interactions" value="608"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K8U7"/>
    <dbReference type="GeneID" id="20678546"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_61272"/>
    <dbReference type="eggNOG" id="KOG0021">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025152_2_1_1"/>
    <dbReference type="InParanoid" id="W4K8U7"/>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.50:FF:000002">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1760:FF:000001">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 10 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="14">
        <location>
            <begin position="219"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="157"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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            <begin position="383"/>
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        </location>
        <ligand>
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        </ligand>
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        </location>
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            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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            <position position="394"/>
        </location>
        <ligand>
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        </ligand>
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        </location>
        <ligand>
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        </ligand>
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        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <ligand>
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        </location>
        <ligand>
            <name>ATP</name>
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        </location>
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        </source>
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        </source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="497" mass="54593" checksum="DED5CF09E69EAC0D" modified="2014-03-19" version="1">MSKFTSWPPELTSEQVEQLTLLATTYALSHSLLYLPPHSASNPPPPSPTSAIHAPFSLLPTPIPRRHFDLVSRLQSTYNVLYSRIAMDEAFLDKIMGEGGVASVDDFTGELWRRWKQLRVEGIVQPLQLGLFRSDYLLDQSSEADPLSLKQVEFNTISSSFGALSQQVSLLHKYLLASTNYFNASPLLKSVNLPFNDTVAGLVSGLAAAHKAYDVESAHILFVVQPGERNIFDQRLLEYELLEKHSIHIIRRSFADLASTATLHPSTRALIVTHNADSVEISTVYYRAGYTPADYPTPAAYDTRQLLERSRAIQCPSLALQLAGGKKVQEVLTHPGVLERFLHADEGLEDIRATWMEMWGLDSDATRSGVDRAREQASQLVLKPQREGGGNNVYKSAIPAFLDSLPERERGAWIAMKLIRPPRGVGGYLVQAGSGGHGIVQSDVVSELGIFGWSLFGNGKVNEEKAVGWLVRTKSEGVDEGGVATGFSVLDSVVLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
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    <name>W4K8Z7_HETIT</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </organism>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Duplessis S."/>
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                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Wiebenga A."/>
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                <person name="Yakovlev I."/>
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            <dbReference type="PubMed" id="22463738"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">TC 32-1</strain>
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    </dbReference>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="749" mass="81273" checksum="D941853238BF2CFD" modified="2014-03-19" version="1"> </sequence>
</entry>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
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                <person name="Raffaello T."/>
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                <person name="de Vries R.P."/>
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                <person name="Yakovlev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="220" mass="24618" checksum="E02129AB6C217B73" modified="2014-03-19" version="1" fragment="single">MGKTWIQETLRRSKSSLITIRRATQRENISLENLPVSQHLSHLQYLYINAGQIPIHMLAQTLKDPAPFLQVLELTCIEQYRTRAIALPLDMFANQLPRLRSLELVNLSFPWATTPLIALVHLKIVLPQRDSAPNPTDPVPPGVQPRPPLALADFLDALEHMTLLETMEILDGLPTPPSGNLHAPAVDHIIRLPRLTSIILKGLAIDCYNLVRCLQIPPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
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            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
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                <person name="Gonthier P."/>
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                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
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                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544940.1">
        <property type="nucleotide sequence ID" value="XM_009546645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KA12"/>
    <dbReference type="FunCoup" id="W4KA12">
        <property type="interactions" value="46"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KA12"/>
    <dbReference type="GeneID" id="20672130"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_382665"/>
    <dbReference type="eggNOG" id="KOG2667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034705_2_1_1"/>
    <dbReference type="InParanoid" id="W4KA12"/>
    <dbReference type="OrthoDB" id="5541786at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF81">
        <property type="entry name" value="ER-DERIVED VESICLES PROTEIN ERV41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="7">
        <location>
            <begin position="31"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="6">
        <location>
            <begin position="178"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW82589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="45155" checksum="721D1BA7E6F9312F" modified="2014-03-19" version="1" fragment="single">MSARTSPSGLGGPSDESSLLDKLDQFAPAPLKSFDAFPKLPSTYKSRSESRGFLTLFVGLLAFLLVLNDIGEFVWGWPDYEFSVDRDAESFMKVNVDLVVNMPCKYLSVDLRDVMGDRMYLSKGFRRDGTLFDIGQATTLKEHAEALSARQAVSQSRKSRGFFSLFKRAPPTYKPTYNYQPDGSACRVYGSLDVKKVTANLHITTLGHGYASSVHVDHNAINMSHVITEFSFGPYFPEITQPLDNSFEITPSPFTAYQYFLRVVPTTYVAPRSDPLITNQYSVTYYTRVLEHNRGTPGIFFKFDMEPMRLTIHQRTTTLAQFLIRCVSWAGVVGGVFVCSAWALRITTRAVTLVAGPSDEDTIAPTPDSAATRASGLRRKWVGGALRARPASGTGQGRVVRQGNSWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4KA52</accession>
    <name>W4KA52_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycerol transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_127299</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544998.1">
        <property type="nucleotide sequence ID" value="XM_009546703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KA52"/>
    <dbReference type="FunCoup" id="W4KA52">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KA52"/>
    <dbReference type="GeneID" id="20666986"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_127299"/>
    <dbReference type="eggNOG" id="KOG3860">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021430_1_1_1"/>
    <dbReference type="InParanoid" id="W4KA52"/>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF18">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE RASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="506"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW82658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="545" mass="62769" checksum="5F7489E928007926" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAG1</accession>
    <name>W4KAG1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_451865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546862.1">
        <property type="nucleotide sequence ID" value="XM_009548567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAG1"/>
    <dbReference type="STRING" id="747525.W4KAG1"/>
    <dbReference type="GeneID" id="20676207"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_451865"/>
    <dbReference type="HOGENOM" id="CLU_128854_0_0_1"/>
    <dbReference type="InParanoid" id="W4KAG1"/>
    <dbReference type="OrthoDB" id="10602344at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="165" mass="17712" checksum="6463C99791B29633" modified="2014-03-19" version="1">MAHRGEGTTTLPGTLPPDAFFSKHAHSTLRTAAHASHERTPSSASGHMHHHAAGAAESTSPAKRRYVADAHGLEIIKKIRQGEVELRDRTIVLCGIKANIRPARFAKLRAIKDAKKPGKAPTAIPAVSGLKRLRGRHRGGAGERGGGERGRRRGRGQRRGREGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBK8</accession>
    <name>W4KBK8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_450871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545508.1">
        <property type="nucleotide sequence ID" value="XM_009547213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBK8"/>
    <dbReference type="GeneID" id="20676087"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_450871"/>
    <dbReference type="HOGENOM" id="CLU_125566_0_0_1"/>
    <dbReference type="InParanoid" id="W4KBK8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="123" mass="14083" checksum="FF2CC6E1DF69FF69" modified="2014-03-19" version="1">MSSNESIYLSSEDTLVERPYEETPSIEPSIPSTPKMSIVEERSVPWDTDKEQAAREAEEGFSKYLEGLDKDERRQDEMIRRLTEDFNRPSPSRSPSPLPLIRTEGTGIIFPDRETYLTTPSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBV3</accession>
    <name>W4KBV3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_426573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545501.1">
        <property type="nucleotide sequence ID" value="XM_009547206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBV3"/>
    <dbReference type="GeneID" id="20674124"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_426573"/>
    <dbReference type="HOGENOM" id="CLU_1749900_0_0_1"/>
    <dbReference type="InParanoid" id="W4KBV3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW83224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="149" mass="16714" checksum="6E5332580FE881BD" modified="2014-03-19" version="1">MKPLLKIGQGINIYPYSAIPVTTGQSSTTGTICIMEHMEGDPSTLCSAAPTLTHGLINLFNVPGGLRIEKKVWILEKAGLDAVWGGKQLLTRCEEEDAWMEVNIQQYLGTDPMFVPRLGEIADSSFEHTAFISRLQRDEKETKEWQYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCK9</accession>
    <name>W4KCK9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chloroperoxidase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cpx1</name>
        <name evidence="9" type="ORF">HETIRDRAFT_170062</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543384.1">
        <property type="nucleotide sequence ID" value="XM_009545089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCK9"/>
    <dbReference type="GeneID" id="20668257"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_170062"/>
    <dbReference type="eggNOG" id="ENOG502QTVQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050230_5_1_1"/>
    <dbReference type="InParanoid" id="W4KCK9"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF18">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="8">
        <location>
            <begin position="88"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW83607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="314" mass="34515" checksum="28D33991AF776535" modified="2014-03-19" version="1">MVPHAYIMSLLTGSIVATSTSIVPPVAESAAPTEALVLSLRLQQLGSCFRRGLLHIAHLLILLIATIVPRRFLPPRQRPHPPVAFPGTGHEFVPRKATDSRSPCPALNTLANHGYLPHNGRDIHASQIVSALREGFHLSLPLSVFLTFGSYLLLGQFRRLSLGDLARHGAIEHDASLARRNARATSEYAPCKLDEDALKALLEDSADGSGLTAHDIARARVRRENSLRVPLDHMHAEIARGEMALVLGIFGQHAGASAVEASQEDEVPLELLSEWWNTERFPDNWRPTRIQGLLQTVRAAADIRKAMEEKQKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDA5</accession>
    <name>W4KDA5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">aTub3</name>
        <name evidence="18" type="ORF">HETIRDRAFT_146577</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 14">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543494.1">
        <property type="nucleotide sequence ID" value="XM_009545199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDA5"/>
    <dbReference type="FunCoup" id="W4KDA5">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KDA5"/>
    <dbReference type="GeneID" id="20667150"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_146577"/>
    <dbReference type="eggNOG" id="KOG1376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015718_1_0_1"/>
    <dbReference type="InParanoid" id="W4KDA5"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000008">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="16">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="17">
        <location>
            <begin position="248"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETW83739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="448" mass="49464" checksum="F0CD2C8EDBE2EBED" modified="2014-03-19" version="1">MREVISIHVGQAGVQIGNACWELYTIEHGLTPDGRFIDKAQVSRAGDGLSTFFSETGSGKYVPRSLYIDLEPGVIDEVKTGTYRSLFHPETMLTGKEDAANNYARGHYTVGKELIDPAMEKLRRLTDNTNGLQGFFVFHSFGGGTGSGFGALLLERLATEYGKKSKLEFCVYPAPQLSSSVVEPYNSVLTTHTTLEHSDCSFMVDNEAIYDICKKRLNVSQPSFTNLNRLIAQVVSSVTVSLRFDGSLNVDLNEFQTNLVPFPRIHFPLATYSPLLSTDKANHEGNTVAEMTLACFEAGNQMVKCDPREGKYMACCLLYRGDVVPKDANAAIASIKTKKTIQFVDWIQTGFKLGVCSEPASTVPGGDLAKTSRSLAMLSNTTAIASAWKRLDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGLDTVEAEEEGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDS8</accession>
    <name>W4KDS8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_458772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545716.1">
        <property type="nucleotide sequence ID" value="XM_009547421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDS8"/>
    <dbReference type="GeneID" id="20676945"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_458772"/>
    <dbReference type="eggNOG" id="ENOG502SS3Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044614_9_3_1"/>
    <dbReference type="InParanoid" id="W4KDS8"/>
    <dbReference type="OrthoDB" id="2744793at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW83470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="415" mass="44516" checksum="B83BD1B438368F02" modified="2014-03-19" version="1">MSSTDIDADALLLQYLGEDFVAGAVSLVFESLLYGAYLVLICFSTLYLSVASRVPRLSSRITDMAASFYFSWRGPKNAHTVALLAVTLLMFAMSSTLLSMDIVNLILTIRGTTIAHLGYSLQDKADMTDDSLIPFFWVENGIFPFEFALGDGVVVWRAWALWKDSNRKALIAPLVLLAGSLGTSVAYVGCTARNGFPHPDANPPGCNDLYLASLCASMATNAAATVLIAWRAWMHRRYLKEMLGASTGKTRVQKVLVLLVESGAIYLAVWISQIYNFFPIAIARGAAYDADLTVTSACNQIVGIYPTLVIVLVSLQRTTWDSPGASRQRHTHTHAHTHTHTGMQFAAAPTPASAVDTSTDTVLSRGGGAGRRDAVHPVSGPFKAQAAGDRESDESGEICGDAAEEEGGKKAGTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDT4</accession>
    <name>W4KDT4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_165755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545721.1">
        <property type="nucleotide sequence ID" value="XM_009547426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDT4"/>
    <dbReference type="GeneID" id="20668006"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_165755"/>
    <dbReference type="HOGENOM" id="CLU_2264099_0_0_1"/>
    <dbReference type="InParanoid" id="W4KDT4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="103" mass="11629" checksum="9EA1FC3D40881B19" modified="2014-03-19" version="1">MLAYRLHANDGHTGRTRSRRNRMGSALDNVGASGGTKHRSRIAHDLVKHEQCKFDDMLQYFLERCLIDPNAAPNDARLSVLQSCLEGVLPICNSEDMKQRLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDX5</accession>
    <name>W4KDX5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear segregation protein Bfr1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_472300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543676.1">
        <property type="nucleotide sequence ID" value="XM_009545381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDX5"/>
    <dbReference type="FunCoup" id="W4KDX5">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KDX5"/>
    <dbReference type="GeneID" id="20677452"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_472300"/>
    <dbReference type="eggNOG" id="ENOG502QRKP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023943_0_0_1"/>
    <dbReference type="InParanoid" id="W4KDX5"/>
    <dbReference type="OrthoDB" id="2195113at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027:SF2">
        <property type="entry name" value="LEBERCILIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="NUCLEAR SEGREGATION PROTEIN BFR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="177"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="281"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="399"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW83949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="58908" checksum="31AEA9DE6521AEB1" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEK8</accession>
    <name>W4KEK8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_449732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543879.1">
        <property type="nucleotide sequence ID" value="XM_009545584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEK8"/>
    <dbReference type="GeneID" id="20675978"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_449732"/>
    <dbReference type="HOGENOM" id="CLU_2831481_0_0_1"/>
    <dbReference type="InParanoid" id="W4KEK8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="66" mass="7065" checksum="BECFD0CD7CC43C7F" modified="2014-03-19" version="1">MGVDVCTDANEDSQPAGGSRAAGTTDERGITSTGRRYDDIRRQTLSSSIFKASRALDSGSALHFYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4KF63</accession>
    <name>W4KF63_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">H/ACA ribonucleoprotein complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Nucleolar protein family A member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_314498</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Common component of the spliceosome and rRNA processing machinery.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543677.1">
        <property type="nucleotide sequence ID" value="XM_009545382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KF63"/>
    <dbReference type="STRING" id="747525.W4KF63"/>
    <dbReference type="GeneID" id="20670133"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_314498"/>
    <dbReference type="eggNOG" id="KOG3167">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084513_0_1_1"/>
    <dbReference type="InParanoid" id="W4KF63"/>
    <dbReference type="OrthoDB" id="5364946at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
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        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
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        <property type="entry name" value="RIBOSOMAL_L7AE"/>
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    </dbReference>
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    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="8">
        <location>
            <begin position="81"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW83950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="206" mass="23072" checksum="059D8DBC839A786D" modified="2014-03-19" version="1">MAKDKSEKIKNVASEPTAEVEDVDMVDAQVRSTVTRNSTHAYTNSAQNERKTKKNKEQISIPLEDLSPIAHPLAQKKLLKKLHKAIKKASKAREVKRGVKEVVKGIRKGERGLLVLAADITPIDIISHLPILSEEAQIPYVFVTSKEELGNASATKRPTSCVMICPNQKKSGKRKEGEVTSKDDDYRELYEECCREVEKLDHKIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFJ3</accession>
    <name>W4KFJ3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_170994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009545868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFJ3"/>
    <dbReference type="GeneID" id="20668315"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_170994"/>
    <dbReference type="HOGENOM" id="CLU_2498134_0_0_1"/>
    <dbReference type="InParanoid" id="W4KFJ3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW84499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="86" mass="9440" checksum="AA3320FF836EBE65" modified="2014-03-19" version="1">MSIFCASGASYGVASAQKLIIATAKTCSEVRVPSAMFMPRQTFGLRDACRNRRRTVITAASKVQPYHAALHLLLDLEKSRCSGERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFU0</accession>
    <name>W4KFU0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_235203</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544244.1">
        <property type="nucleotide sequence ID" value="XM_009545949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFU0"/>
    <dbReference type="STRING" id="747525.W4KFU0"/>
    <dbReference type="GeneID" id="20668747"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_235203"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002074_1_0_1"/>
    <dbReference type="InParanoid" id="W4KFU0"/>
    <dbReference type="OrthoDB" id="411857at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="299"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="344"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="863"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="898"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="18"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW84594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1200" mass="133243" checksum="45BA2CBF77F4ED50" modified="2014-03-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFY7</accession>
    <name>W4KFY7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_103262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544387.1">
        <property type="nucleotide sequence ID" value="XM_009546092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFY7"/>
    <dbReference type="STRING" id="747525.W4KFY7"/>
    <dbReference type="GeneID" id="20665884"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_103262"/>
    <dbReference type="HOGENOM" id="CLU_127785_0_0_1"/>
    <dbReference type="InParanoid" id="W4KFY7"/>
    <dbReference type="OrthoDB" id="3056853at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="181" mass="19168" checksum="BA902BD18575F4A9" modified="2014-03-19" version="1">MSDLDADLYADLYGTDDADFVADPTVKVPPAHEEAQEPTSQAIDKTSDSAIPLHSRPVKADPPEEPSSAPTTPTTAPVSSAPVASSSTTLVPKPESADSTGGQPQSTAATPVPALVTQQIPTYQEPLEDDYHASYGGAANGGYQQISVQERSIRPSEMKDEGKYSWKGSLAVTIMFYRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGI6</accession>
    <name>W4KGI6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Prolyl endopeptidase</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_408499</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of Pro-|-Xaa &gt;&gt; Ala-|-Xaa in oligopeptides.</text>
            <dbReference type="EC" id="3.4.21.26"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase S9A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544094.1">
        <property type="nucleotide sequence ID" value="XM_009545799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGI6"/>
    <dbReference type="STRING" id="747525.W4KGI6"/>
    <dbReference type="GeneID" id="20672684"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_408499"/>
    <dbReference type="eggNOG" id="KOG2237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011290_1_1_1"/>
    <dbReference type="InParanoid" id="W4KGI6"/>
    <dbReference type="OrthoDB" id="248387at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070012">
        <property type="term" value="F:oligopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.120:FF:000001">
        <property type="entry name" value="Prolyl endopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000005">
        <property type="entry name" value="Prolyl endopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.120">
        <property type="entry name" value="Prolyl oligopeptidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051167">
        <property type="entry name" value="Prolyl_oligopep/macrocyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881:SF2">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50993">
        <property type="entry name" value="Peptidase/esterase 'gauge' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S9A N-terminal" evidence="9">
        <location>
            <begin position="12"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="8">
        <location>
            <begin position="533"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW84420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="751" mass="84354" checksum="7239FF6D55915A3D" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4KH75</accession>
    <name>W4KH75_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase active site lid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_154603</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542081.1">
        <property type="nucleotide sequence ID" value="XM_009543786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KH75"/>
    <dbReference type="FunCoup" id="W4KH75">
        <property type="interactions" value="538"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KH75"/>
    <dbReference type="GeneID" id="20667508"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_154603"/>
    <dbReference type="eggNOG" id="KOG3078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032354_1_2_1"/>
    <dbReference type="InParanoid" id="W4KH75"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036193">
        <property type="entry name" value="ADK_active_lid_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57774">
        <property type="entry name" value="Microbial and mitochondrial ADK, insert 'zinc finger' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="6">
        <location>
            <begin position="137"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW85208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="227" mass="25728" checksum="858D3A2DD90D93F8" modified="2014-03-19" version="1">MPSRRSEQSEQHALGIQRQSQARQSLLCSLLVGKGTQAPRIHDQFCQVNQKTKLGVEAKKIMDAGGLVSDDIMVGMIKDQLENNEACKNGFVLDGFPRTVPQAEKLDSMLFERKEKLDSVVQLEIPDELLISRITGRLIHPASGRTYHREFHPPKKAMTDDVTGEPLIQRSDDNVETLTKRLKSFHSQTTPVVQYYKNKGLWHRIDAAQSPSVVWDNLRKVFTAKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHG9</accession>
    <name>W4KHG9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DOPA 4,5-dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_44314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541812.1">
        <property type="nucleotide sequence ID" value="XM_009543517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHG9"/>
    <dbReference type="GeneID" id="20675507"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_44314"/>
    <dbReference type="eggNOG" id="ENOG502S305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090062_1_0_1"/>
    <dbReference type="InParanoid" id="W4KHG9"/>
    <dbReference type="OrthoDB" id="9970095at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1240">
        <property type="entry name" value="DOPA-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023389">
        <property type="entry name" value="DOPA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014980">
        <property type="entry name" value="DOPA_dioxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423:SF2">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08883">
        <property type="entry name" value="DOPA_dioxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143410">
        <property type="entry name" value="DOPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="20556" checksum="F6275B3696168149" modified="2014-03-19" version="1">MAPPTDLQEVLDTEIKEWHFHIYFHQNNADEHQSALELRDAVLRLRRDGAFVAVPLFRVNTAPIGPHPVGSYEIWCPSESFASVFSYLCINRGELSILVHPLTRDEICRDHDTRKAWIGPSFPLDLSTLPIKSDTVPLQYPSLKFGYSSTAEPVPLSDRKKIGSHIERILEKEKEAAKAPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHQ2</accession>
    <name>W4KHQ2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_424615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542117.1">
        <property type="nucleotide sequence ID" value="XM_009543822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHQ2"/>
    <dbReference type="STRING" id="747525.W4KHQ2"/>
    <dbReference type="GeneID" id="20673990"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_424615"/>
    <dbReference type="HOGENOM" id="CLU_083072_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHQ2"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="299" mass="33654" checksum="575DD67A99B4CF67" modified="2014-03-19" version="1">MSSSESIYLSSEDTLVERPYEETPSTEPSIPLTPEMSIVEERSVPWDTDKEQAAREAEEGFSEYLEGLDKDERRQDEMIRLLTEDFNRPSPSRSPSPPPLVRTQSEGIIFPDRETYLTTPVAYMMGLIEGTPNTEFVSGPTRPEVRRALEILEEERSFVRHAQRALQIREGTLIARINAGERKLIGLDQTTPLQDTFHPADDITPVTEYHMPTMAVVSRASSSASNGAPLHPMPGAYPTERGRGRDVYRFAQLSPRYHVIPARLGLICPSTRTRLPLPFVEYDSSESDTQPIILRPRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4KI50</accession>
    <name>W4KI50_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatidylinositol-specific phospholipase C X domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_311254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542229.1">
        <property type="nucleotide sequence ID" value="XM_009543934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KI50"/>
    <dbReference type="STRING" id="747525.W4KI50"/>
    <dbReference type="GeneID" id="20669855"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_311254"/>
    <dbReference type="eggNOG" id="ENOG502QUGH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024117_6_0_1"/>
    <dbReference type="InParanoid" id="W4KI50"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="37014" checksum="E5371E0DE4176254" modified="2014-03-19" version="1" fragment="single">ILLFEKRNLAAFLSQVPDRTPLHSLSLPGAMAFYGWPVSQCQSTDTPLLVQLVSGIRMLDIRLSLIKGKLLSYHSTYPQRTPFLKILSDLHAFLTSPISSRETLVVSIKQENYADVGAIEFSMAVRRDILQGPGGLDMWFLENRIPRLGEVRGRAIMFSRFGADGTGWDRGLEGMGIHPTRWPDSAKEGFTWELKGTLVRTHDWYHIPSFLSIPEKVDLSTSMLMPSANNISTPVLSITYFSASSFPFATPTVVSTGFGWPRFGFGVEGVNSRVARRLLDALSETVDRRADLGEGPRIRAWTLMDFFLEPGDAGVVPLLVECNFRGRAGERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KI86</accession>
    <name>W4KI86_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_311361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542272.1">
        <property type="nucleotide sequence ID" value="XM_009543977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KI86"/>
    <dbReference type="STRING" id="747525.W4KI86"/>
    <dbReference type="GeneID" id="20669864"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_311361"/>
    <dbReference type="eggNOG" id="ENOG502SS2A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100697_0_0_1"/>
    <dbReference type="InParanoid" id="W4KI86"/>
    <dbReference type="OrthoDB" id="2497589at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="174" mass="17978" checksum="ABF8A758D3C67636" modified="2014-03-19" version="1" fragment="single">GRKRKTDEAGMATRGSAKAARVSVSPDSKAKGGKRGPKANLAASQFKARALPLHINVTNTPPSIADGESAPATSVDPGFIGTTTLLPSTFSTGSYGWKGSKRITIELPNPDSGDDSKEKVHVMLTINATVMGSKNAKEEPEGKGGEEVEVAEEEGAKGESLDEGNEAAVAEEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KII0</accession>
    <name>W4KII0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_121129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544479.1">
        <property type="nucleotide sequence ID" value="XM_009546184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KII0"/>
    <dbReference type="GeneID" id="20666735"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_121129"/>
    <dbReference type="HOGENOM" id="CLU_125566_0_0_1"/>
    <dbReference type="InParanoid" id="W4KII0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW84851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="141" mass="15912" checksum="806E6F5AF8EA5B81" modified="2014-03-19" version="1">MSSSESIYLSSEDTLATQPYKETPSTEPSIPTTPKMSIVEEQSVPWDTDEEQAAREAEEGFDEYLRRLDENKQQEDEMIRRLTEDFNRPAPSHSPSPPPLIHTQGDGIIFPDRETYLMTPVAYMMGLIEGTPNTEFVSGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIT6</accession>
    <name>W4KIT6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_310850</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542585.1">
        <property type="nucleotide sequence ID" value="XM_009544290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIT6"/>
    <dbReference type="GeneID" id="20669806"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_310850"/>
    <dbReference type="HOGENOM" id="CLU_2038366_0_0_1"/>
    <dbReference type="InParanoid" id="W4KIT6"/>
    <dbReference type="OrthoDB" id="340346at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="121" mass="13252" checksum="8EFF6F702342EF8A" modified="2014-03-19" version="1">MQDGCVTLRGLAIPLTGCLSDPRGHTRAGISETVQGWANLGPHPTASDHVDVYHVLLMARWDPRFIAGLGDGMGATAVGGVLRWGEDLCAILMRDVVKQYIFLLFVLRVSPTYISHLLVYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJ15</accession>
    <name>W4KJ15_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA repair protein, SNF2 family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HETIRDRAFT_414818</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542655.1">
        <property type="nucleotide sequence ID" value="XM_009544360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJ15"/>
    <dbReference type="FunCoup" id="W4KJ15">
        <property type="interactions" value="433"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KJ15"/>
    <dbReference type="GeneID" id="20673204"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_414818"/>
    <dbReference type="eggNOG" id="KOG0390">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_10_2_1"/>
    <dbReference type="InParanoid" id="W4KJ15"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000010">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000332">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013967">
        <property type="entry name" value="Rad54_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08658">
        <property type="entry name" value="Rad54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="242"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="581"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETW85838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="819" mass="93126" checksum="D771852181141C33" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJD4</accession>
    <name>W4KJD4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_154378</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542616.1">
        <property type="nucleotide sequence ID" value="XM_009544321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJD4"/>
    <dbReference type="FunCoup" id="W4KJD4">
        <property type="interactions" value="1154"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KJD4"/>
    <dbReference type="GeneID" id="20667489"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_154378"/>
    <dbReference type="eggNOG" id="KOG1863">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003532_2_1_1"/>
    <dbReference type="InParanoid" id="W4KJD4"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000011">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000005">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000215">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024729">
        <property type="entry name" value="USP7_ICP0-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029346">
        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF644">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14533">
        <property type="entry name" value="USP7_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12436">
        <property type="entry name" value="USP7_ICP0_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="10">
        <location>
            <begin position="46"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="204"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW85794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1104" mass="126971" checksum="1BD7C785C9F9A8C0" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJJ2</accession>
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        </recommendedName>
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        <name evidence="3" type="ORF">HETIRDRAFT_414994</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ETW86022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KJJ2"/>
    <dbReference type="GeneID" id="20673215"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_414994"/>
    <dbReference type="eggNOG" id="KOG4775">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012263_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJJ2"/>
    <dbReference type="OrthoDB" id="1933281at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013665">
        <property type="entry name" value="Sfi1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08457">
        <property type="entry name" value="Sfi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sfi1 spindle body" evidence="2">
        <location>
            <begin position="441"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="279"/>
        </location>
    </feature>
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        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1154"/>
        </location>
    </feature>
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        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
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            <end position="201"/>
        </location>
    </feature>
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            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
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            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="1141"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW86022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1154" mass="133022" checksum="2B962EA0D90E2AB8" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJJ8</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_141426</name>
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    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009544051.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="20667005"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_141426"/>
    <dbReference type="HOGENOM" id="CLU_2979351_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJJ8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="58" mass="6613" checksum="429B4B26675918C7" modified="2014-03-19" version="1">MSPRCAGLMMRKHRRSSCWLTTVRADALGLNLLSYHTRKARVGKRHDVRGGYGRGRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KK61</accession>
    <name>W4KK61_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_432675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009544694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KK61"/>
    <dbReference type="FunCoup" id="W4KK61">
        <property type="interactions" value="400"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KK61"/>
    <dbReference type="GeneID" id="20674626"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_432675"/>
    <dbReference type="eggNOG" id="KOG3234">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_7_1_1"/>
    <dbReference type="InParanoid" id="W4KK61"/>
    <dbReference type="OrthoDB" id="10264728at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="N-terminal acetyltransferase complex ARD1 subunit homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
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        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051646">
        <property type="entry name" value="NatB_acetyltransferase_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW86232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="183" mass="20721" checksum="5805F490005E4503" modified="2014-03-19" version="1">MSVLRPFRATDMFKFNNVNLDIWTETYGVPFYLTYLGRWPDLCCVQTAPSGRLMGYVIGKAEGSQTEHHGHVTALTVAPEYRRLALARKMMQLLESVSDETYGGFFVDLYVRCANAVAIGMYEGLGYSVYRRVREYYGSLGLGVAGKDEEDAFDMRKPLSRDPMRRSVRANGRDMFVSAHDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KK83</accession>
    <name>W4KK83_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_470877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542565.1">
        <property type="nucleotide sequence ID" value="XM_009544270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KK83"/>
    <dbReference type="GeneID" id="20677366"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_470877"/>
    <dbReference type="HOGENOM" id="CLU_2542830_0_0_1"/>
    <dbReference type="InParanoid" id="W4KK83"/>
    <dbReference type="OrthoDB" id="3242721at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844297" evidence="1">
        <location>
            <begin position="20"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="83" mass="8976" checksum="2A1A657532F51169" modified="2014-03-19" version="1">MSLKLPCTILSLRLTLVYPTLFCVVLLSTSQNPRAIAYSGVPHIYLGLSCGGPTPYLTVQISAAVDHATTITLFYHMILGCFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKQ3</accession>
    <name>W4KKQ3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450 monooxygenase 63</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">cyp63</name>
        <name evidence="12" type="ORF">HETIRDRAFT_58475</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540368.1">
        <property type="nucleotide sequence ID" value="XM_009542073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKQ3"/>
    <dbReference type="GeneID" id="20678434"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_58475"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_3_1"/>
    <dbReference type="InParanoid" id="W4KKQ3"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW86402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="528" mass="59978" checksum="61AC67B2815AD9DE" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKR5</accession>
    <name>W4KKR5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endonuclease</fullName>
            <ecNumber evidence="10">3.1.30.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_443574</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.30.-" evidence="10"/>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542496.1">
        <property type="nucleotide sequence ID" value="XM_009544201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKR5"/>
    <dbReference type="FunCoup" id="W4KKR5">
        <property type="interactions" value="141"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KKR5"/>
    <dbReference type="GeneID" id="20675532"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_443574"/>
    <dbReference type="eggNOG" id="KOG3721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055174_0_2_1"/>
    <dbReference type="InParanoid" id="W4KKR5"/>
    <dbReference type="OrthoDB" id="5418055at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00091">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.570.10:FF:000008">
        <property type="entry name" value="Probable NUC1-dna/rna non-specific nuclease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018524">
        <property type="entry name" value="DNA/RNA_endonuclease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01070">
        <property type="entry name" value="NUCLEASE_NON_SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="13">
        <location>
            <begin position="86"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="12">
        <location>
            <begin position="87"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW85661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="344" mass="37260" checksum="E99D3FDC2E8E07EA" modified="2014-03-19" version="1">MPSATVIRAAFFAVGAAVGGGVATALGVSKRKELAVAVPASTSASQNFPVIDTGAKGDLRLSPSAKSEIVPVLKYGNPGPLSDQLVRKAYAAAYDRRLRHPAWTAEHLTASSLGRSGSGKGSSESEKGDRQKSQFKEDEAIPLPFRARLQDYFRSGYDRGHMVPAADAKKSQDAMDETFLLSNIAPQVGAGFNRHYWAYVEDWCRRLTGSFADVYVFTIPLYLPHRDPDGKWRVTHEVIGNPPNISVPTHFAKVVLTSRPSSPSTPNVFEISTGAFVLPNAIIPDEAPLESFVVPVETVERAAGLTLFSDAIKNGSKHICKTTKCDVIVRRFDDAQKKPKAISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLK8</accession>
    <name>W4KLK8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_380107</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542733.1">
        <property type="nucleotide sequence ID" value="XM_009544438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLK8"/>
    <dbReference type="FunCoup" id="W4KLK8">
        <property type="interactions" value="231"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KLK8"/>
    <dbReference type="GeneID" id="20672002"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_380107"/>
    <dbReference type="eggNOG" id="KOG1379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029404_7_1_1"/>
    <dbReference type="InParanoid" id="W4KLK8"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="52"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW85931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="332" mass="36646" checksum="D3BE1AA3EA8AF6A9" modified="2014-03-19" version="1">MPAWTRFASSMPRPYRFHVGASWIAKPPEPRSRKKVKPFPGDSPIGLWRNETLSRASSSSSKDAGEDFFYVQDMRNQSGVSLGVADGVGGWAESGVDPSLFSQALMYHAHRYSSSAWPGEPEIDPTQEYEEREEVEGWELLPGNCMQLALEGVLRERAVLAGSSTACIVNLNASSGILRAANLGDSGFMIIRSSTVFYRQKSQTHFFNCPRQLAKLPIRADSDAMDYPSDADIYETKLRDGDIIVAYTDGLSDNVFNNEITAICSLVSRAGGPEDMQVQTMADRTAEFARACMVNRTRVSPFEKAAAREGFYFRGGKLDDVTVLVALVREVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLR2</accession>
    <name>W4KLR2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_414971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542787.1">
        <property type="nucleotide sequence ID" value="XM_009544492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLR2"/>
    <dbReference type="GeneID" id="20673213"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_414971"/>
    <dbReference type="HOGENOM" id="CLU_104307_0_0_1"/>
    <dbReference type="InParanoid" id="W4KLR2"/>
    <dbReference type="OrthoDB" id="3204463at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="236" mass="26304" checksum="4B91B0FC8DD6D4FC" modified="2014-03-19" version="1">MPPIAAPQPRRPRPSSPLLQSPTHPRYHISQDDPFICCTPKLKPSQSAFTLESPPLLSPIRFQDRTKRGVMSKSPTPCSSIRGSSSIPLAISRSPRRRRHLSSLKCPFPPRIPSDFDNLPWIDLLSSPSFAQDAWDGSDLSQLIPEDTRPVASHREGPGPIRRRKLSPRTAPHARSLHARSPQRPAELPALLSGRRGSSIAPHTPPPRFHPSKTHFFNLMPIMTDSPLSEARFPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLR5</accession>
    <name>W4KLR5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nascent polypeptide-associated complex subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha-NAC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_457580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAC-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542791.1">
        <property type="nucleotide sequence ID" value="XM_009544496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLR5"/>
    <dbReference type="FunCoup" id="W4KLR5">
        <property type="interactions" value="457"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KLR5"/>
    <dbReference type="GeneID" id="20676848"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_457580"/>
    <dbReference type="eggNOG" id="KOG2239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057806_2_0_1"/>
    <dbReference type="InParanoid" id="W4KLR5"/>
    <dbReference type="OrthoDB" id="3169036at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22054">
        <property type="entry name" value="NAC_NACA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14358">
        <property type="entry name" value="UBA_NAC_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000002">
        <property type="entry name" value="Nascent polypeptide-associated complex (NAC), alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016641">
        <property type="entry name" value="EGD2/NACA0like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21713">
        <property type="entry name" value="NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015901">
        <property type="entry name" value="NAC_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAC-A/B" evidence="6">
        <location>
            <begin position="44"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="121"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW86001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="198" mass="21534" checksum="90D7E9CB2338E309" modified="2014-03-19" version="1">MSATIEEVQSDHSEHEHEHDHDHDHEHDHEEDPTSAAALEKIQSRSERKARKALLSLGLKKVPGITRVTLRRPKNFLFVIASPDVYKSQNSDCYIVFGEAKMEDMNAQAQLNAAQQLAQSGGSLPNLENSGAGGDGDDDDDIPDLEAPEDEGPVDETGIDPKDIELVMAQVNCSRAKAVRVLKESGGDLINAIMAASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMJ2</accession>
    <name>W4KMJ2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_413404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541005.1">
        <property type="nucleotide sequence ID" value="XM_009542710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMJ2"/>
    <dbReference type="GeneID" id="20673107"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_413404"/>
    <dbReference type="eggNOG" id="ENOG502T0KA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104696_0_0_1"/>
    <dbReference type="InParanoid" id="W4KMJ2"/>
    <dbReference type="OrthoDB" id="4991875at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="226" mass="22232" checksum="A51A49505319FEBC" modified="2014-03-19" version="1">MALQYAKGDTSLYIPGFGDQPLSVANIGDDNAGQTTWQVVGGTPTGTFQSAAFAGTATLIEGPHAAFVTAHAPSGIGIAILCSVLNGIATCTEVVDGKTTIVIELVTVIVVQGGGTAPVQPATSIFSSPATATVTVTAIATSSSQPSFSPQITSSIAPSTTNSQSQSASAASITATPTPTQDNVGTTILPSASLIPAVSGAKGRQDSGLETAVAIIAVFASLVIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KN20</accession>
    <name>W4KN20_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_166748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541142.1">
        <property type="nucleotide sequence ID" value="XM_009542847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KN20"/>
    <dbReference type="GeneID" id="20668083"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_166748"/>
    <dbReference type="HOGENOM" id="CLU_2109351_0_0_1"/>
    <dbReference type="InParanoid" id="W4KN20"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW87212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="115" mass="12235" checksum="AC2A4D433110AA82" modified="2014-03-19" version="1">MVPTQKVAIASHVNGIRLLLLGLGFNGHSVFDPMALSDHPLFLILASACRELSLACSAHGRALSSSHRHLLVSHLACAGSCFVGEQHCVLQQMKEAVLSVCVYCCHRATTDAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNM2</accession>
    <name>W4KNM2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">5-hydroxyisourate hydrolase</fullName>
            <shortName evidence="7">HIU hydrolase</shortName>
            <shortName evidence="7">HIUHase</shortName>
            <ecNumber evidence="7">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_305763</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="7"/>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540946.1">
        <property type="nucleotide sequence ID" value="XM_009542651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNM2"/>
    <dbReference type="FunCoup" id="W4KNM2">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KNM2"/>
    <dbReference type="GeneID" id="20669349"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_305763"/>
    <dbReference type="eggNOG" id="KOG3006">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115536_0_1_1"/>
    <dbReference type="InParanoid" id="W4KNM2"/>
    <dbReference type="OrthoDB" id="10265230at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05822">
        <property type="entry name" value="TLP_HIUase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="entry name" value="Transthyretin/hydroxyisourate hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023418">
        <property type="entry name" value="Thyroxine_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023419">
        <property type="entry name" value="Transthyretin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395:SF7">
        <property type="entry name" value="5-HYDROXYISOURATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="URICASE AND TRANSTHYRETIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00095">
        <property type="entry name" value="TR_THY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="Transthyretin (synonym: prealbumin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00768">
        <property type="entry name" value="TRANSTHYRETIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00769">
        <property type="entry name" value="TRANSTHYRETIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transthyretin/hydroxyisourate hydrolase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW86990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="132" mass="14842" checksum="390FCA5A2436BEB7" modified="2014-03-19" version="1">MSKSPITCHVLDSSLGKPATGVQVSLQECYSPAFDGGPVIWEPLAHGYTNSDGRCMDLLPARGSEEAKDKNVELKAGSTYKIVFKTKDYFERSGRRCFYPWVEIPFEVLNPTEHYHIPLLISPYSYTTYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4KP13</accession>
    <name>W4KP13_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_244376</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the assembly of mitochondrial cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the COX19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541468.1">
        <property type="nucleotide sequence ID" value="XM_009543173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KP13"/>
    <dbReference type="FunCoup" id="W4KP13">
        <property type="interactions" value="197"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KP13"/>
    <dbReference type="GeneID" id="20669047"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_244376"/>
    <dbReference type="eggNOG" id="KOG3477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141947_2_1_1"/>
    <dbReference type="InParanoid" id="W4KP13"/>
    <dbReference type="OrthoDB" id="268594at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051383">
        <property type="entry name" value="COX19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW87583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9910" checksum="F80CD130E81443F8" modified="2014-03-19" version="1" fragment="single">MSFGRPPSISGGFQVNPPDRGSFPLDHDGECKEAMMRYLDCLRKHASASTECRHLNRDYLGCRMKKGLMEPDEWKNLGLSNLKGDDPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPD3</accession>
    <name>W4KPD3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_167279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541572.1">
        <property type="nucleotide sequence ID" value="XM_009543277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPD3"/>
    <dbReference type="GeneID" id="20668114"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_167279"/>
    <dbReference type="HOGENOM" id="CLU_744061_0_0_1"/>
    <dbReference type="InParanoid" id="W4KPD3"/>
    <dbReference type="OrthoDB" id="3249478at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="372" mass="41665" checksum="C18A9C7E135E94C4" modified="2014-03-19" version="1">MQSSQQYTRHQLRTSLDHNESMAFVKHPRVHSQAGSISSQFSTSSTLVDVAETPESPGDEHVMMQLDYILPVWEYPGNYIPSTPSSILLPEPSTTSPTPCSSSHHLVSSVSTRGSRLWLHRRRRLATDNQTTTASNTRSSFLTSLLHSRWPKSELEDPIFGQTTPRALSPHRQHFHDEHDRDLLPPVRERPPSTLSAPRSILTRVDSRDKRSVRSFKGSVKFVEKPKLWEYEEYYGDYGFDNERQNRWNVGQVKDDVDEADSVMTLPPSTARSRARSESILRRFIGSSGKSHARGHGKGKKVQGIGEKLVISGPMPLVKAASMRDLKQSSDPDRKGNVKEKGTNMASGAGATKKGNKLRTFWGRLYCGMGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPD8</accession>
    <name>W4KPD8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homoserine kinase</fullName>
            <ecNumber evidence="3">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_239849</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-homoserine + ATP = O-phospho-L-homoserine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13986"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="3"/>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541576.1">
        <property type="nucleotide sequence ID" value="XM_009543281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPD8"/>
    <dbReference type="FunCoup" id="W4KPD8">
        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KPD8"/>
    <dbReference type="GeneID" id="20668836"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_239849"/>
    <dbReference type="eggNOG" id="KOG1537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041243_2_1_1"/>
    <dbReference type="InParanoid" id="W4KPD8"/>
    <dbReference type="OrthoDB" id="195231at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF1">
        <property type="entry name" value="HOMOSERINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861">
        <property type="entry name" value="HOMOSERINE/4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00958">
        <property type="entry name" value="HOMSERKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="13">
        <location>
            <begin position="75"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW87708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="352" mass="37404" checksum="E4A0ADCA3B746243" modified="2014-03-19" version="1" fragment="single">MSSRSRVFTIRVPATSANIGPGFDVVGLSLSLYLTLTVTISTASSDSSSSSTPAPPTLVYSGEGSDEVPLDAYKNLTTRVALYVLRCHGVSTFPQHLTIHAHNEIPFGRGLGSSGAAVIAGVLLGSELGALSLSRERALDFALMVERHPDNVTAALVGGFVGSYLRELAPEAALAASVPLSEVLPEFPPDAGPDWGRDPPVPPPGIGHFVRFGWAKEIKAVAIIPRFELSTARAREVLPESYSRKDLVFNLQRLAVLTTALAQSPPNAELIYEAMKDRIHQPYRKSLIPGLPEVTSSITPNTHPGLLGICLSGAGPTILALAVGGFEAIAEDARTIFREKGIEVDWKLLDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPE3</accession>
    <name>W4KPE3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U2 small nuclear ribonucleoprotein A'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_443290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the U2 small nuclear ribonucleoprotein A family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541460.1">
        <property type="nucleotide sequence ID" value="XM_009543165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPE3"/>
    <dbReference type="FunCoup" id="W4KPE3">
        <property type="interactions" value="912"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KPE3"/>
    <dbReference type="GeneID" id="20675514"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_443290"/>
    <dbReference type="eggNOG" id="KOG1644">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061027_1_0_1"/>
    <dbReference type="InParanoid" id="W4KPE3"/>
    <dbReference type="OrthoDB" id="433501at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000026">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044640">
        <property type="entry name" value="RU2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552:SF6">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW87574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="255" mass="28121" checksum="ABA93C4F82E62F84" modified="2014-03-19" version="1">MKLTPELIAQAPSSLNALKERQLDLRGYKIPAIENLGVTKDQHDAIDLTDNSIVALGNFPLLRRLHTLLIANNRIASISSSIHLSTPNLTTLVLTNNNIQELGDLEPLRELKGLKYLTLLGNPVQEKKWYREWIAWRIPGLRVLDFQRIRDKVPSLPPLHERKAAKGLFLTADGLENSLASSLSTTASTQSTKQTISTDEPRLAVAPGKAGRLMSKEEADKVKAAIAKATSIEEIRRLERSLKEGFVPSLEAVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPG3</accession>
    <name>W4KPG3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_305254</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541478.1">
        <property type="nucleotide sequence ID" value="XM_009543183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPG3"/>
    <dbReference type="FunCoup" id="W4KPG3">
        <property type="interactions" value="158"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KPG3"/>
    <dbReference type="GeneID" id="20669310"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_305254"/>
    <dbReference type="eggNOG" id="KOG0247">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_9_0_1"/>
    <dbReference type="InParanoid" id="W4KPG3"/>
    <dbReference type="OrthoDB" id="123929at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF1008">
        <property type="entry name" value="KINESIN-LIKE PROTEIN SUBITO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="101"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="718"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="7"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="728"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="786"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="820"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="834"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="200"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW87594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="909" mass="99371" checksum="AAA61174197BDC1A" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPK2</accession>
    <name>W4KPK2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_413953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541516.1">
        <property type="nucleotide sequence ID" value="XM_009543221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPK2"/>
    <dbReference type="GeneID" id="20673146"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_413953"/>
    <dbReference type="HOGENOM" id="CLU_2638349_0_0_1"/>
    <dbReference type="InParanoid" id="W4KPK2"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW87639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="77" mass="8922" checksum="6A311ACB171A399B" modified="2014-03-19" version="1">MIDRPSSAFSHKSLRKCVTFQPLAPDVQCRMWTALAEVGLNVNEGSFAHEAEHTWTIDIETEVGRLMYLRMRRSRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPQ3</accession>
    <name>W4KPQ3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_306114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541661.1">
        <property type="nucleotide sequence ID" value="XM_009543366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPQ3"/>
    <dbReference type="GeneID" id="20669380"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_306114"/>
    <dbReference type="HOGENOM" id="CLU_3143248_0_0_1"/>
    <dbReference type="InParanoid" id="W4KPQ3"/>
    <dbReference type="OrthoDB" id="2630497at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW87803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="49" mass="5796" checksum="C1B2595459BE6F5D" modified="2014-03-19" version="1">MLTKYWEMEAHGTNFVKPLLEVLNDKEHYEVKIILDLKQQGCGTKYLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPR5</accession>
    <name>W4KPR5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytoskeleton assembly control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_447658</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLA2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540999.1">
        <property type="nucleotide sequence ID" value="XM_009542704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPR5"/>
    <dbReference type="FunCoup" id="W4KPR5">
        <property type="interactions" value="147"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KPR5"/>
    <dbReference type="GeneID" id="20675796"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_447658"/>
    <dbReference type="eggNOG" id="KOG0980">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004601_0_0_1"/>
    <dbReference type="InParanoid" id="W4KPR5"/>
    <dbReference type="OrthoDB" id="10262320at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17007">
        <property type="entry name" value="ANTH_N_Sla2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1410.10:FF:000004">
        <property type="entry name" value="Cytoskeleton assembly control protein Sla2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000021">
        <property type="entry name" value="Cytoskeleton assembly control protein Sla2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035964">
        <property type="entry name" value="I/LWEQ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002558">
        <property type="entry name" value="ILWEQ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030224">
        <property type="entry name" value="Sla2_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407:SF15">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01608">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00307">
        <property type="entry name" value="ILWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="6">
        <location>
            <begin position="34"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="I/LWEQ" evidence="7">
        <location>
            <begin position="834"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="291"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW87051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1080" mass="122058" checksum="9CC8F6A96751387C" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPS1</accession>
    <name>W4KPS1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA (cytosine(38)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.204</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">DNA (cytosine-5)-methyltransferase-like protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_306746</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.204" evidence="4"/>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541681.1">
        <property type="nucleotide sequence ID" value="XM_009543386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPS1"/>
    <dbReference type="FunCoup" id="W4KPS1">
        <property type="interactions" value="222"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KPS1"/>
    <dbReference type="GeneID" id="20669432"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_306746"/>
    <dbReference type="eggNOG" id="KOG0919">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049101_0_0_1"/>
    <dbReference type="InParanoid" id="W4KPS1"/>
    <dbReference type="OrthoDB" id="414133at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050750">
        <property type="entry name" value="C5-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031303">
        <property type="entry name" value="C5_meth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46098">
        <property type="entry name" value="TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46098:SF1">
        <property type="entry name" value="TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00095">
        <property type="entry name" value="C5_MTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844561" description="tRNA (cytosine(38)-C(5))-methyltransferase" evidence="8">
        <location>
            <begin position="25"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW87823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="329" mass="37053" checksum="67CDE8F56BA1077A" modified="2014-03-19" version="1" fragment="single">ALTFFLRCVLGGLHLALERSTIRGKVVRAFDWDQTACQVYSANRGADVVQKVDISTLGAAELARYAADLWLLSPSCQPYTVLNPLAKGAADPRARSFLHLVENVLPPLVASGAHPHYLLIENVAGFETSSTRQVLLQTLKGLGYATLELLLTPLQLGIPNSRLRYYLLAKMAPLTFKFPADGEPERDRVWRHIPGRGADWDQRHQHAIPDKVLEKWGRLFDIVVPSARRTCCFTRGYTQLVERAGSVLQENEALDAAEIPGAVTLLHPLRLRYFSPKELLRLFYFESCKDGGEGVFQWPERVSRKSQYRLIGNSVNVRVVRELIDFLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPX5</accession>
    <name>W4KPX5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GPI inositol-deacylase</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_241646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541052.1">
        <property type="nucleotide sequence ID" value="XM_009542757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPX5"/>
    <dbReference type="STRING" id="747525.W4KPX5"/>
    <dbReference type="GeneID" id="20668899"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_241646"/>
    <dbReference type="eggNOG" id="ENOG502QQNH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015737_1_0_1"/>
    <dbReference type="InParanoid" id="W4KPX5"/>
    <dbReference type="OrthoDB" id="5592486at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="2">
        <location>
            <begin position="72"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW87111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="264" mass="28844" checksum="D00DE9F78D81737A" modified="2014-03-19" version="1" fragment="single">PKHPVVFCHGLLGFDSVTIGPAIAPLEVSHWRGIKEVLEANGTEVLITRVPATSSPVDRAKVLERTIEAAYPGRAVHLIGHSMGGLDCRYLTTHLRTHTFTVLSLTTLATPHRGSAFADHFLATVGRARLPSVLALLDLLPNGGGDGAAFECLTRESMRAFNDATPDVLGVRYFSWGAQYEPGLIDTWKWPHSVILEQEGPNDGLVSVESSKWGTYLGTLHDVNHLDLVGWINAARYKWAALCGREIQFRPATFYLGVADLLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4KRJ3</accession>
    <name>W4KRJ3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HETIRDRAFT_306455</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541560.1">
        <property type="nucleotide sequence ID" value="XM_009543265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KRJ3"/>
    <dbReference type="FunCoup" id="W4KRJ3">
        <property type="interactions" value="578"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KRJ3"/>
    <dbReference type="GeneID" id="20669406"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_306455"/>
    <dbReference type="eggNOG" id="KOG0344">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_4_1"/>
    <dbReference type="InParanoid" id="W4KRJ3"/>
    <dbReference type="OrthoDB" id="360161at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17957">
        <property type="entry name" value="DEADc_DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044764">
        <property type="entry name" value="DDX52/Rok1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF15">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="166"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="370"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="61"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="534"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="544"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETW87691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="573" mass="63750" checksum="DBC6357B9532997B" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMG2</accession>
    <name>W4JMG2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_423377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JMG2"/>
    <dbReference type="GeneID" id="20673902"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_423377"/>
    <dbReference type="HOGENOM" id="CLU_115504_0_0_1"/>
    <dbReference type="InParanoid" id="W4JMG2"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW74718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="206" mass="23534" checksum="1C97A5960C3AEAF8" modified="2014-03-19" version="1">MSSHCDPDITITPTTSPVEEFRKVSATRSLPLQQHIVKAFRGVPKKLQLQWDPSDHIYTKAELAKLLPLPNLPRALVPRPGMEVPPCLLYGLPISRERIFLLAKLRDPNMQLFAKSGLISIELKRSVTDSLRKEISWPVYLDRALNTPDTPYIPCILDNFSIEACVECNEMPKGNHIRRMRKALGAHPKARLMWYTAAGYYIWQCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPN8</accession>
    <name>W4JPN8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_108000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552853.1">
        <property type="nucleotide sequence ID" value="XM_009554558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPN8"/>
    <dbReference type="GeneID" id="20666297"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_108000"/>
    <dbReference type="HOGENOM" id="CLU_1294567_0_0_1"/>
    <dbReference type="InParanoid" id="W4JPN8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW75434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="213" mass="23366" checksum="6E60C7C2B04435F4" modified="2014-03-19" version="1">MTFFARIYSRRGDQHLLSQSGGKPQATVQYTYFQLLNIQVRPSIDGQIWRLSEGLTVSTTLTADRQASPRNRSKLLACFERLSLSLTALKRQTHDRLRASPTVRAQPPTRGNIWRSLTLTARYALPPLLTGDFQVLRVPAPAPASSSYLKLFFAQRGCECGGGGSGGCAGQARGLRGAGESFASAERRRRNAPHGYGFTPGCICTPMTRYPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPP0</accession>
    <name>W4JPP0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_456507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW75055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553501.1">
        <property type="nucleotide sequence ID" value="XM_009555206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPP0"/>
    <dbReference type="STRING" id="747525.W4JPP0"/>
    <dbReference type="GeneID" id="20676749"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_456507"/>
    <dbReference type="eggNOG" id="KOG0029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004498_3_1_1"/>
    <dbReference type="InParanoid" id="W4JPP0"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001716">
        <property type="term" value="F:L-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF342">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="301" mass="33463" checksum="A7CDF6D894578BE6" modified="2014-03-19" version="1">MRQCGTVPHGEYDDQVISYLEIFDTGTGFYDLALSEIVLDFLDFEYDGDEMWYCIQGDASVIANAMAQKLPEGKIFNGKRVTAIAPTTSRDQPPRTYSHVISTISLSCLRMVDTSHCKFSWGLQTAIRSLHYATSTKVTIKFNERWWERMGQVGGVSNTDRPTRAVVYPSYGIGGTDATMIVSYTWAQDVSRFSPFSGNRDSEKAPLDVISRDLADMHGTKDHNDLRNLVSDHGAFAHFGPGQFSQLYPQVTKPAANGKLHFAGEATSVYHGWVVSALNSAARAIYELAYCEGREDLVQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPS9</accession>
    <name>W4JPS9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_482267</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552940.1">
        <property type="nucleotide sequence ID" value="XM_009554645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPS9"/>
    <dbReference type="STRING" id="747525.W4JPS9"/>
    <dbReference type="GeneID" id="20678020"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_482267"/>
    <dbReference type="eggNOG" id="KOG1812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1310291_0_0_1"/>
    <dbReference type="InParanoid" id="W4JPS9"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097039">
        <property type="term" value="P:protein linear polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF13">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW75538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="210" mass="23195" checksum="E06BB87DC94E701A" modified="2014-03-19" version="1">MPAHPERLACGHVYCTNCLRHFLTTAATRTTFPLVCMGNGAQCGSPILIPVIRRFVPAQHAFDALLRAAFLAHLERHTDEYKFCTTPDCTQIYRASTPGSEGAFVECPSCFGAVCTACHEEAHESFSCGERAKVQEKENERLFSVWAGQNGVKHCPACKIPIERIDGCNHIACRCGRHICWKCMAVFDTSEQTYGHMTAAHGGPFDYNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQ25</accession>
    <name>W4JQ25_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_456460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553437.1">
        <property type="nucleotide sequence ID" value="XM_009555142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQ25"/>
    <dbReference type="STRING" id="747525.W4JQ25"/>
    <dbReference type="GeneID" id="20676744"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_456460"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_6_3_1"/>
    <dbReference type="InParanoid" id="W4JQ25"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="6"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW74981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="425" mass="46467" checksum="53866DF54DEF86CD" modified="2014-03-19" version="1">MQPFLKVAICGGGIGGLTLASFLSKKLTNGSIAVDVYETNSDIRTIGAGIAIWKRYWDVLQDLLNIENDCLERGISLPKDNGVRGPTLRKSDLSSGGHDFYSLTQGPMIISRVALLDILQTKLDSAICTIHTSKRLVCYTSTEPQDPVTLHFADGTTATADLLVGADGIHSRVRMTMFADFPIYAQPRFSGQLAYRMQADIKKNTSERLLRLSQSPGMTIWCGKGRHVTSNTLGDAIHITAYDNVSADNDGPLPDPWVLDVPVQEVSDNFRDWEPDLVSLLRSAHTASRWAIHVVNALPRFVSGKVALLGDAAHAMTPHQGLGAGQGIEDAYILCLLLAHRATTASNLMDVLEIYDRIRLPQAQRVAAQSLSNGLAYGFLLDRFEGMPLETIGQELGESVQWLMSAQGCQEEWAKAEAMMDELNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRQ3</accession>
    <name>W4JRQ3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_390120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552018.1">
        <property type="nucleotide sequence ID" value="XM_009553723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRQ3"/>
    <dbReference type="GeneID" id="20672439"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_390120"/>
    <dbReference type="eggNOG" id="KOG1804">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001666_6_3_1"/>
    <dbReference type="InParanoid" id="W4JRQ3"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032574">
        <property type="term" value="F:5'-3' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18038">
        <property type="entry name" value="DEXXQc_Helz-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026122">
        <property type="entry name" value="MOV-10/SDE3_DEXXQ/H-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418">
        <property type="entry name" value="CANCER/TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418:SF1">
        <property type="entry name" value="CANCER_TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="5">
        <location>
            <begin position="510"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="5">
        <location>
            <begin position="604"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="6">
        <location>
            <begin position="680"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW75760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="935" mass="104274" checksum="B961D3F0CF7F3D71" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRR2</accession>
    <name>W4JRR2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_412354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552463.1">
        <property type="nucleotide sequence ID" value="XM_009554168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRR2"/>
    <dbReference type="GeneID" id="20673020"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_412354"/>
    <dbReference type="HOGENOM" id="CLU_2654800_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRR2"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="76" mass="8279" checksum="A68D1BF3FBDDA7E2" modified="2014-03-19" version="1">MGTINRRPVTTALVKQWSSISNRSSLWTAFDVAERSIPPRVPFTPPKGENPISPQDELDMSLVSGSSRVGIIANIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRT3</accession>
    <name>W4JRT3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_446844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552472.1">
        <property type="nucleotide sequence ID" value="XM_009554177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRT3"/>
    <dbReference type="GeneID" id="20675717"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_446844"/>
    <dbReference type="HOGENOM" id="CLU_2574166_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRT3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="81" mass="8980" checksum="F7FF92CC8B4BEB9D" modified="2014-03-19" version="1">MNGDSMQRQVHGVEGSHVHAWAQRQNWLLRELSERTGLALEIEGVAGSAERIRALLLTLLVNTLERVWHDVCYALCVGSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSC0</accession>
    <name>W4JSC0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HETIRDRAFT_328115</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
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                <person name="Hansson D."/>
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                <person name="Hietala A."/>
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                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
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                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
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</entry>
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                <person name="van Diepen L.T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Yakovlev I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551758.1">
        <property type="nucleotide sequence ID" value="XM_009553463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTW5"/>
    <dbReference type="GeneID" id="20677953"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_481035"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_2_1"/>
    <dbReference type="InParanoid" id="W4JTW5"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW76894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="302" mass="34769" checksum="03EB42B6541D6211" modified="2014-03-19" version="1">MLSSFNSTQPKHSDSIAIVFKQHRLRHSFTVMAQSLRRLKMAVSRYLRIISMSAYCCPNQLVYIIKRIITVQIHHPSPVLLVSLLPHLWYQRKGKHPYSSLPFPPGPKRLPFIGNLFNLPRGHDASVYRDWSREFGSEIVHLDVIGMHAIVVNSAKAAREIFEKRSLLYSDRPSFLVLNKMLGFRWALGFMPYGRKWRNTRKAFHSCFNSTASLRYHRLDLQASHELLRRLLDTPQAFVEHVRHVVVDLILEIAYGSNMRSMGDTGDDYVIIAEKTLDAMLIGSTPHAVLLDLFPIRELALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4JU76</accession>
    <name>W4JU76_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_441691</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009552358.1"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JU76"/>
    <dbReference type="GeneID" id="20675385"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_441691"/>
    <dbReference type="eggNOG" id="KOG0272">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_6_3_1"/>
    <dbReference type="InParanoid" id="W4JU76"/>
    <dbReference type="OrthoDB" id="2658414at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="287"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="835"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="871"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="914"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="957"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1000"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1043"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1086"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1129"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1172"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1215"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1258"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1301"/>
            <end position="1333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW77107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1499" mass="165062" checksum="E14428BC2542A11A" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUI7</accession>
    <name>W4JUI7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_454569</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550755.1">
        <property type="nucleotide sequence ID" value="XM_009552460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUI7"/>
    <dbReference type="STRING" id="747525.W4JUI7"/>
    <dbReference type="GeneID" id="20676532"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_454569"/>
    <dbReference type="eggNOG" id="ENOG502S7YV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070882_2_1_1"/>
    <dbReference type="InParanoid" id="W4JUI7"/>
    <dbReference type="OrthoDB" id="9936937at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058841">
        <property type="entry name" value="HTH_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040554">
        <property type="entry name" value="KPWE_PEX14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855:SF1">
        <property type="entry name" value="PEROXISOME MEMBRANE ANCHOR PROTEIN PEX14P N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25871">
        <property type="entry name" value="HTH_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17733">
        <property type="entry name" value="KPWE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEX14-like helix-turn-helix" evidence="3">
        <location>
            <begin position="7"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxisomal membrane protein PEX14-like KPWE" evidence="2">
        <location>
            <begin position="103"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW77218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="161" mass="18053" checksum="2EEBE47D45AB7507" modified="2014-03-19" version="1">MADLPTDVLQLYATHPFDSDELYQQGLSSIISNDALAATPDEEKEALLRRTRIFYFEKIKGLTISEDEARRAEELYAKPTNMSPDTSALQAPSEFGEEQGKEPRHLSFAELKTLIEQGRTDEIPYNKQIPDKLNDAPPSTSTVPQRRKPWELGTAQAAESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUS8</accession>
    <name>W4JUS8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_109313</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550779.1">
        <property type="nucleotide sequence ID" value="XM_009552484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUS8"/>
    <dbReference type="GeneID" id="20666430"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_109313"/>
    <dbReference type="HOGENOM" id="CLU_078964_0_0_1"/>
    <dbReference type="InParanoid" id="W4JUS8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
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        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="53"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW77244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="266" mass="29950" checksum="B5EDB2EDFCE8BF70" modified="2014-03-19" version="1">MSSSSALLPLLNGTHHLSPLALPVPEPFSHFPMTDIHNALPYPYADPFPGNRLPPIPVFDNTGRPISRPSSPSYDPEQAAREHEIHHSTPVSPPRAGSPSDWINHVREAERAGAAAHPPSPLINGWPRDGVRAAERVWPPLLDPSPSPPPLVLPPPATDTRLCWECDRPGHLIANCPITRIRRRTDLTARNFIRDYEVYGEVVELLSTQLEHVAENYGYYWHIRDRMIDDARWEGHPTRHTPVMDPRTFMALPIRDPDAVTSQRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4JV81</accession>
    <name>W4JV81_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 monooxygenase 100</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cpm100</name>
        <name evidence="11" type="ORF">HETIRDRAFT_147842</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550984.1">
        <property type="nucleotide sequence ID" value="XM_009552689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JV81"/>
    <dbReference type="STRING" id="747525.W4JV81"/>
    <dbReference type="GeneID" id="20667229"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_147842"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_5_11_1"/>
    <dbReference type="InParanoid" id="W4JV81"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW77483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="521" mass="57605" checksum="E016A672BBFE0241" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVB8</accession>
    <name>W4JVB8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Electron transfer flavoprotein-ubiquinone oxidoreductase</fullName>
            <shortName evidence="19">ETF-QO</shortName>
            <ecNumber evidence="19">1.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">HETIRDRAFT_479677</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 19">Accepts electrons from ETF and reduces ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + oxidized [electron-transfer flavoprotein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24052"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.5.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="19">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ETF-QO/FixC family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.1" evidence="19"/>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550581.1">
        <property type="nucleotide sequence ID" value="XM_009552286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JVB8"/>
    <dbReference type="FunCoup" id="W4JVB8">
        <property type="interactions" value="250"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JVB8"/>
    <dbReference type="GeneID" id="20677881"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_479677"/>
    <dbReference type="eggNOG" id="KOG2415">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009667_4_0_1"/>
    <dbReference type="InParanoid" id="W4JVB8"/>
    <dbReference type="OrthoDB" id="437331at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000015">
        <property type="entry name" value="Electron transfer flavoprotein-ubiquinone oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040156">
        <property type="entry name" value="ETF-QO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049398">
        <property type="entry name" value="ETF-QO/FixC_UQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007859">
        <property type="entry name" value="ETF-QO/FixX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617:SF107">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21162">
        <property type="entry name" value="ETFQO_UQ-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05187">
        <property type="entry name" value="Fer4_ETF_QO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 19" id="KW-0274">FAD</keyword>
    <keyword evidence="6 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 19" id="KW-0408">Iron</keyword>
    <keyword evidence="14 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 19" id="KW-0813">Transport</keyword>
    <keyword evidence="15 19" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="21">
        <location>
            <begin position="565"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU366068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ETW77025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="605" mass="65805" checksum="CD77109DF6590CBF" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWX9</accession>
    <name>W4JWX9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_163938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549976.1">
        <property type="nucleotide sequence ID" value="XM_009551681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWX9"/>
    <dbReference type="STRING" id="747525.W4JWX9"/>
    <dbReference type="GeneID" id="20667879"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_163938"/>
    <dbReference type="eggNOG" id="ENOG502SKZI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015091_1_0_1"/>
    <dbReference type="InParanoid" id="W4JWX9"/>
    <dbReference type="OrthoDB" id="2657661at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="634"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="684"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="721"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW77964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="790" mass="88174" checksum="474EE75719B2E7C5" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXA8</accession>
    <name>W4JXA8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alcohol dehydrogenase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_388291</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550178.1">
        <property type="nucleotide sequence ID" value="XM_009551883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXA8"/>
    <dbReference type="STRING" id="747525.W4JXA8"/>
    <dbReference type="GeneID" id="20672361"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_388291"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_1"/>
    <dbReference type="InParanoid" id="W4JXA8"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF2">
        <property type="entry name" value="DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="4">
        <location>
            <begin position="34"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW78183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="435" mass="46437" checksum="D486E8BC6373107E" modified="2014-03-19" version="1">MSTTIPETQLAVRWYPASFDVRLENVPTPMIEHPDDAIVKITFAGLCGSDLHVYRGLEDVHEIHICGHEFIGHVVALGSSFSPLSPPSRPELYATLQVGDKIVSPFTTSCGECSPCRRGFTARCTSSFLFGTPVLPGGQAQYTRVPKAGGTLFVLPSSISPNASAPFLDVATFMALPDPTLLLLADILPTGLFVALQALSHPKLSPFTANTSWPNTMDGILYSHISTSAAPLMEDDRVLTIGVVGLGPVGLCAILALLDLLEHRQLPTRFRIVASDLNKSRRAKMQNMYNALPAPSKGPVGSEFIVCGVESLPTWARHGCHAVLEVVGTPPALTLALSLLAPSGVLSSCGVHQAPPIPFTGRELYNLNVTLEFGRCSVRALFGAAAGLLARRRDVLGVVGEAGVVERVVSLRDAVSAYEMFEQGRCGKVVFDAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXH0</accession>
    <name>W4JXH0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein PBDC1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_460697</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PBDC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551069.1">
        <property type="nucleotide sequence ID" value="XM_009552774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXH0"/>
    <dbReference type="FunCoup" id="W4JXH0">
        <property type="interactions" value="459"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JXH0"/>
    <dbReference type="GeneID" id="20677101"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_460697"/>
    <dbReference type="eggNOG" id="KOG4093">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103791_1_0_1"/>
    <dbReference type="InParanoid" id="W4JXH0"/>
    <dbReference type="OrthoDB" id="10248897at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3560.10:FF:000001">
        <property type="entry name" value="Protein PBDC1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3560.10">
        <property type="entry name" value="yst0336 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023139">
        <property type="entry name" value="PBDC1-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008476">
        <property type="entry name" value="PBDC1_metazoa/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021148">
        <property type="entry name" value="Polysacc_synth_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410:SF9">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04669">
        <property type="entry name" value="PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide biosynthesis" evidence="5">
        <location>
            <begin position="16"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW77586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="168" mass="19954" checksum="3934A5EDA6A06EEF" modified="2014-03-19" version="1">MTTRFDPNNAQNLVEIEKQFAVKAVEHAQTYWNLLEKIHPSQLKLTRLDDEIFEHMMKTFPEISQEHQKLTVLDEDWMKSKDGKERWRQFMAAYEKKVQDYNFGSLIRTNATKEYSETNTIFVTRIQFYAIEISRNRLGLNDKAHEIAKEEARKQQEKIDKAKKKGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYF0</accession>
    <name>W4JYF0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_103973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548905.1">
        <property type="nucleotide sequence ID" value="XM_009550610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYF0"/>
    <dbReference type="GeneID" id="20665960"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_103973"/>
    <dbReference type="HOGENOM" id="CLU_647335_0_0_1"/>
    <dbReference type="InParanoid" id="W4JYF0"/>
    <dbReference type="OrthoDB" id="3237746at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="47073" checksum="EBBDECB1D27EB85B" modified="2014-03-19" version="1">MLIFGETFIGALGGLVDCAAAVHGQLHFGRNHIKLQLLDTICSPQLDQSIVTALANCAPCKNFRGMHLYSILEPITRCRPFELLVADYLSLPKGTNGFHTVGLYLDTYFQCIWGFKYKTHSTAKTTISGLTTITTSWTKPNTFMTDGVIAAYSAWVNGLVEGTNKILLGRLKRLCSPELGEDECTDVKPEDIPKNWPKYFDQVIEWLNNCILPALHHSPNELALGLVINTPKASPNTAEAPPSIAEVERQLAYTEQQRLNGYAFTVDHAHKRKAAFNRRVVSAAPAEVIFARFDLVQVYRNALDFTLFYSKQAASQMVTPPAHPSRRLKKFVPRSGTKLAQEQATLLQDKEGHPKEDGTDGPIFPSEQTEHPLLEDSPSEDPANEDKSEGSNTSDLKDDAETEDKEDESRPRAGRALRSGRIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYR1</accession>
    <name>W4JYR1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_441477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550011.1">
        <property type="nucleotide sequence ID" value="XM_009551716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYR1"/>
    <dbReference type="STRING" id="747525.W4JYR1"/>
    <dbReference type="GeneID" id="20675368"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_441477"/>
    <dbReference type="HOGENOM" id="CLU_1170774_0_0_1"/>
    <dbReference type="InParanoid" id="W4JYR1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="237" mass="25615" checksum="82D91CAAA60806C7" modified="2014-03-19" version="1">MNTDDTGDVDLALDITGTGTGPDADDTDAEPSAVRGEFSQSVFAAGPSAQHSRNQQPSFERLPPGAFHDSDHDDYADNEPVSVRQTRVRTPSPPPPAKTRIPVRVRKTPGKRTTRDPTLKRSLPGAFTAMGDDEDDRLGQRHGHDNDNDNDGEDDEIAPLPKRPLRRSRATRPSTSSVDGEDDAEVRPVRRSSRLSVASSSPEPMSPQKLSTGTGGRTRKAASTTATPGKTRSSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYS3</accession>
    <name>W4JYS3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_453301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549014.1">
        <property type="nucleotide sequence ID" value="XM_009550719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYS3"/>
    <dbReference type="GeneID" id="20676364"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_453301"/>
    <dbReference type="HOGENOM" id="CLU_1704451_0_0_1"/>
    <dbReference type="InParanoid" id="W4JYS3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="154" mass="16897" checksum="40C4BB81A4649CFF" modified="2014-03-19" version="1">MAKSHPEPTHFDDALVDLPTIEMQQTGAALEPPSDVNSRVGKIVESDVDVPVPLEYWQRTEYTAAKHSSAHMTGTCALSVRGTEDGRTASRPSTRRDTIGGYAARTTALVWALRPQRGADRNTWLANAPAQSGKRRTRARPAGFPRSNDAMRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZY3</accession>
    <name>W4JZY3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_50226</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WD repeat peroxin-7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548769.1">
        <property type="nucleotide sequence ID" value="XM_009550474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZY3"/>
    <dbReference type="FunCoup" id="W4JZY3">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JZY3"/>
    <dbReference type="GeneID" id="20678134"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_50226"/>
    <dbReference type="eggNOG" id="KOG0277">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046581_1_0_1"/>
    <dbReference type="InParanoid" id="W4JZY3"/>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005053">
        <property type="term" value="F:peroxisome matrix targeting signal-2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044536">
        <property type="entry name" value="PEX7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027:SF1">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="109"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="152"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="209"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="263"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW78650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="344" mass="37956" checksum="292D01908A7C59E5" modified="2014-03-19" version="1">MNSRPPGVLHTPGFAHYNLAWSPFHTNRIAVASSANYGLVGNGRLHLASVILGPGPLSSVVLDKFYETQDGIYDVAWSEVHENQLVTGSGDGSIKLWDIMLNDLPIRAWQEHTREVFCVDWSNIQKDQFISCSWDGTVKLWTPERPRSLTTLQAHHSCVYQALFSPHNPNLLSTCSTDGTVKVFDLRQPSFSPAANSFTAPLATAAITVPASGTEVLALDWNKYREMVLASGGVDKTVRVWDCRMVPPVEGGGAVGGVCEAQLMGHEYAVRKVQWSPHRPDIIASAGYDMTCRIWTTAPPAGRTHLMHIHDPHTEFVVGCAWSLYDEGLLASCSWDCRLNVFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4K012</accession>
    <name>W4K012_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_477946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548993.1">
        <property type="nucleotide sequence ID" value="XM_009550698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K012"/>
    <dbReference type="GeneID" id="20677788"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_477946"/>
    <dbReference type="eggNOG" id="ENOG502S9U1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1704450_0_0_1"/>
    <dbReference type="InParanoid" id="W4K012"/>
    <dbReference type="OrthoDB" id="2097653at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004843928" evidence="1">
        <location>
            <begin position="26"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="154" mass="15890" checksum="BC62D646EDEB3965" modified="2014-03-19" version="1">MQSRIALLSFWALLAALLAINGASAREVRNEHTHLVRVRRELVERADLTVQPQCTDPSVKLNSHDCNVALLSTGTGIAGKIQFLRVAGTTTTGTSGTCSVKVDAVDGGTAIDISKGRFEQAFKALVAACGVSPGTVTAAGGSTGGNTKITISHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4K014</accession>
    <name>W4K014_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_454379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550411.1">
        <property type="nucleotide sequence ID" value="XM_009552116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K014"/>
    <dbReference type="STRING" id="747525.W4K014"/>
    <dbReference type="GeneID" id="20676500"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_454379"/>
    <dbReference type="eggNOG" id="ENOG502R1CZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033082_1_0_1"/>
    <dbReference type="InParanoid" id="W4K014"/>
    <dbReference type="OrthoDB" id="3218112at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="33"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="269" mass="29997" checksum="BD7084D9AC834F9A" modified="2014-03-19" version="1">MASIDTPSDRERPRTELDAELLINHPALYFDDGDVILQCGKTLFRVHRGILLKHSTLFQEMLAPARDTLRDCTLLKVVDDKDDMEAFLNTIHDGFTIDASHITIEKLPTLSGILRLAYKYRPHTEDLIVHPAAVIALLRSINYADNALLSALFYDLNRRTQQLGGAYGHHLASLSEADIGRLMSCHALVSGFWHSPAGQRCLLNMQDLISQPVENWELVKGQVQGTLALPGLSLTGLCSTCRAEMVKYVGQQQATLWGSLSRHFDLAEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4K040</accession>
    <name>W4K040_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alanine--glyoxylate transaminase</fullName>
            <ecNumber evidence="3">2.6.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">AGT1</name>
        <name evidence="12" type="ORF">HETIRDRAFT_142962</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.44" evidence="3"/>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549361.1">
        <property type="nucleotide sequence ID" value="XM_009551066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K040"/>
    <dbReference type="STRING" id="747525.W4K040"/>
    <dbReference type="GeneID" id="20667023"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_142962"/>
    <dbReference type="eggNOG" id="KOG2862">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027686_5_2_1"/>
    <dbReference type="InParanoid" id="W4K040"/>
    <dbReference type="OrthoDB" id="7403325at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004760">
        <property type="term" value="F:L-serine-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019265">
        <property type="term" value="P:glycine biosynthetic process, by transamination of glyoxylate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000049">
        <property type="entry name" value="Alanine-glyoxylate aminotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000027">
        <property type="entry name" value="Serine--pyruvate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152:SF24">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152">
        <property type="entry name" value="AMINOTRANSFERASE CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="11">
        <location>
            <begin position="28"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW79094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="388" mass="41339" checksum="171B0CC5130A9599" modified="2014-03-19" version="1">MSAQSFHQAPHKLLLIPGPVEVTDEVLFANAHPSVSHMSAEFVSAFGDSLRMTREVVYSKDAQPFLISGSGTLGWDQVSSNLVEAGENALVLNTGYFGESFADCLRTYGANVDQIKAELGTTVSLKEVEKALQAKKYKIVTITHVDTSTAVLSNPKAVAEVVRRVSPDTLVILDAVCAVASEEIRMDDWSIDVVVSASQKGLGAPPGLSVVVASQKALQVAAARSTPVSSYYASWKRWLPIMTAYEKGSAAYFATPPVNLIFAFNQSLTQIVKGSSSLEERFKLHADASNRLKAAAKELGLKQLAADPSIAANGMTALWCPPGVKSSELLPLFLKKGVVIAGGLGAEKDNYFRIGHMGTTVANAERGDVERIIAVLKEVIAEATSKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4K053</accession>
    <name>W4K053_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_108675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550445.1">
        <property type="nucleotide sequence ID" value="XM_009552150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K053"/>
    <dbReference type="STRING" id="747525.W4K053"/>
    <dbReference type="GeneID" id="20666371"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_108675"/>
    <dbReference type="HOGENOM" id="CLU_1428170_0_0_1"/>
    <dbReference type="InParanoid" id="W4K053"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="190" mass="20833" checksum="63D4FFC690027649" modified="2014-03-19" version="1">MQAQHRAFILSDTLTHNCDLLRHTYHLGYSTPLTLILPLSPSQFSVSRLPPPEPAPWDQGPRVLPAPIIDLTDPDPDTPPPMRTPHPTSIFAPLTPPLLLSWPPISRGAHLAAQMVLRVRPTTRLPRCSSQAPPHRLRRSFPRSLHSPRLTRPRHPRTLPSPSPLPAAAPAASPVPHAKSSPTSPAICKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0C8</accession>
    <name>W4K0C8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_242589</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="3"/>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549502.1">
        <property type="nucleotide sequence ID" value="XM_009551207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0C8"/>
    <dbReference type="FunCoup" id="W4K0C8">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K0C8"/>
    <dbReference type="GeneID" id="20668939"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_242589"/>
    <dbReference type="eggNOG" id="KOG2278">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052998_1_1_1"/>
    <dbReference type="InParanoid" id="W4K0C8"/>
    <dbReference type="OrthoDB" id="419694at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW79252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="208" mass="22298" checksum="30CB3D9A96D2EBC9" modified="2014-03-19" version="1" fragment="single">LSKTLSWLLRHGAQSEKLPMRADGFVRVQDLVSAPALATPKLAAQLDWPALQRIVAADTKQRYTLLSEPPSDAAASADAIWWIKANQGHSIKARPAPIPTPTTSPRMSPITSPTDVPMAVHGTTRKAWQSISRQGLSRMSRNHIHLAQGIPGDGIISGMRASAQILIHIDLPKALAAGIPFSLSDNGVVLSAGDARGFLHPAFFSRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4K182</accession>
    <name>W4K182_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_322544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548064.1">
        <property type="nucleotide sequence ID" value="XM_009549769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K182"/>
    <dbReference type="GeneID" id="20670870"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_322544"/>
    <dbReference type="HOGENOM" id="CLU_1619253_0_0_1"/>
    <dbReference type="InParanoid" id="W4K182"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="164" mass="17956" checksum="F2516389AA4D706B" modified="2014-03-19" version="1">MKWECELISFKVPLLAYNRAGQGNGKHVCLSRLLTRPDFGLHSRLVIGRPNQTGINLKIHHLFCLVSPPPDVHWARFAPREGQWHDGGVFPLSHPHPKPDLASASPASSWLPERWLKGSASGDKCLSRPEGNAGEDIGTPGHLHIILQRRATPKIGVLLGAVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1B5</accession>
    <name>W4K1B5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_321418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548191.1">
        <property type="nucleotide sequence ID" value="XM_009549896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1B5"/>
    <dbReference type="GeneID" id="20670747"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_321418"/>
    <dbReference type="HOGENOM" id="CLU_3032613_0_0_1"/>
    <dbReference type="InParanoid" id="W4K1B5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="55" mass="6024" checksum="59E2E80E21782845" modified="2014-03-19" version="1">MGVGGGGLETKSIMSLWTVAHALRPLRLGPSWKYASTLSSFPKTLSLIQRCFCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1J3</accession>
    <name>W4K1J3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EXPERA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_124417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548256.1">
        <property type="nucleotide sequence ID" value="XM_009549961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1J3"/>
    <dbReference type="STRING" id="747525.W4K1J3"/>
    <dbReference type="GeneID" id="20666870"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_124417"/>
    <dbReference type="eggNOG" id="ENOG502S97T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076143_2_1_1"/>
    <dbReference type="InParanoid" id="W4K1J3"/>
    <dbReference type="OrthoDB" id="60858at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919:SF2">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919">
        <property type="entry name" value="PROTEIN CBG05606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="20814" checksum="3A67855816EDE1E7" modified="2014-03-19" version="1">MALKTYSWITFWFLASAPVIFWDAGYCFFRPRSMKGGDLHWIWKPYEIYQEIDYVRVYGVKALAENNGFTNAQSALNIVETLLNLLYAYLAHISHSPIAPAVGFASVTMTLSKTVLYWLNEYFCGWCSIGHNAPRDLLVYWIIPNGIWLVVPSCVLYTLGRDIARALRAHARPAARESKKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4K209</accession>
    <name>W4K209_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_322797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548372.1">
        <property type="nucleotide sequence ID" value="XM_009550077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K209"/>
    <dbReference type="GeneID" id="20670910"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_322797"/>
    <dbReference type="HOGENOM" id="CLU_2671362_0_0_1"/>
    <dbReference type="InParanoid" id="W4K209"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="75" mass="8783" checksum="53D631C59C5AA8F5" modified="2014-03-19" version="1">MTLVPHPRPTPFRILHSRKILVILLRRVPFFLQILRFVSVVTMRNIMSLQEDPIVLRLGTLRGLIMVPSRVQQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2I5</accession>
    <name>W4K2I5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_171465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_171465"/>
    <dbReference type="HOGENOM" id="CLU_2867920_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2I5"/>
    <dbReference type="Proteomes" id="UP000030671">
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    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="64" mass="6896" checksum="82768B7EFAED1229" modified="2014-03-19" version="1">MPAHCIAAPTAAPSAALLLIVLSISISIKRCQTRFLIWIVTLFLPACLDLLDIDSFITSIRSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2I6</accession>
    <name>W4K2I6_HETIT</name>
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        <name evidence="10" type="ORF">HETIRDRAFT_171910</name>
    </gene>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Schmutz J."/>
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                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
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            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="protein sequence ID" value="ETW79565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009549846.1"/>
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    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Cytochrome P450"/>
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        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="EP450I"/>
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    </dbReference>
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    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
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    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
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        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW79565.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="524" mass="58940" checksum="0A839DFDA42BB9C3" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2Y0</accession>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
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                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_322244"/>
    <dbReference type="HOGENOM" id="CLU_2590058_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2Y0"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW80172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="80" mass="8535" checksum="625AAC54DAADB657" modified="2014-03-19" version="1">MLYALERSASLADSSQLTRGQCILRIGRVQACAVSISRLDQGGTAHGRLLPHVTLPVFAALDYCKRAAVDPDAPKQSKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4K303</accession>
    <name>W4K303_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="1 2">
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        <lineage>
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            <taxon>Agaricomycetes</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547945.1">
        <property type="nucleotide sequence ID" value="XM_009549650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K303"/>
    <dbReference type="STRING" id="747525.W4K303"/>
    <dbReference type="GeneID" id="20678103"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_49374"/>
    <dbReference type="eggNOG" id="ENOG502S71Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138679_2_0_1"/>
    <dbReference type="InParanoid" id="W4K303"/>
    <dbReference type="OrthoDB" id="2107880at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061671">
        <property type="term" value="C:Cbp3p-Cbp6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037653">
        <property type="entry name" value="Cbp6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250:SF1">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20180">
        <property type="entry name" value="UQCC2_CBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="104" mass="12005" checksum="9C3CEAE28FCA54BB" modified="2014-03-19" version="1">MSTSTKLAQQLRRISAEWPNDPLRPNMQLKTFLNSLADHPKLSPAAVTAAQVLQENRISKKFPIPEKILKPASMPYHYDRLVEGYEKSLKGIGRPWWKIFFGVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4K334</accession>
    <name>W4K334_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">6-phosphogluconate dehydrogenase C-terminal domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_320728</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547009.1">
        <property type="nucleotide sequence ID" value="XM_009548714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K334"/>
    <dbReference type="STRING" id="747525.W4K334"/>
    <dbReference type="GeneID" id="20670686"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_320728"/>
    <dbReference type="eggNOG" id="ENOG502RXGX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052530_0_0_1"/>
    <dbReference type="InParanoid" id="W4K334"/>
    <dbReference type="OrthoDB" id="9988102at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015814">
        <property type="entry name" value="Pgluconate_DH_NAD-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF2">
        <property type="entry name" value="CYTOKINE-LIKE NUCLEAR FACTOR N-PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09130">
        <property type="entry name" value="DUF1932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844050" description="6-phosphogluconate dehydrogenase C-terminal domain-like protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="3">
        <location>
            <begin position="4"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphogluconate dehydrogenase NAD-binding putative C-terminal" evidence="4">
        <location>
            <begin position="206"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW80233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="32200" checksum="26E124E01CE46179" modified="2014-03-19" version="1">MSHTIAIVAAGAMGSAVAARLTAAGCTVLTNLDGRSDATRRRALEAGMIDVPFTDIPRRASCMLSIIPPSDAQSLAERYLEACRASANAGVATPVYVDCNAVNPQTVKGIATLFKQTGVGFVDAGIIGGPPREGYFPTFYASADQHDLFALGALEELRTYGMKLAVLKGDGAGAGDASALKMSYAGITKGLTGLFTTMILSANAASPATTTALLRELHASQPALLQRATRSIPDMLPKAYRWISEMEEISEFVGEPLQDVHKGMSNVYRRVRDSVGGDGDDQRVLEKFVKDAIEILEKERESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4K344</accession>
    <name>W4K344_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_410305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548071.1">
        <property type="nucleotide sequence ID" value="XM_009549776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K344"/>
    <dbReference type="GeneID" id="20672855"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_410305"/>
    <dbReference type="HOGENOM" id="CLU_1594749_0_0_1"/>
    <dbReference type="InParanoid" id="W4K344"/>
    <dbReference type="OrthoDB" id="3243492at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="18254" checksum="91BDBD7B255465A7" modified="2014-03-19" version="1">MPDQSNIVPDSTKSYPSSRADIAIHSIHDGPRRPASDDAMPPKFVRMERVQEAGLCAGNKHLPDCKDIPTIKGDSVGVVASQKGCSHSRPVTATKGKDRNTALKTQKKPSKNARVPCPKEGCNTTFASNSERNRHVRTSRDHVSQGTFKCDFCGDLLSRNDRSRCPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4K389</accession>
    <name>W4K389_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_171926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548127.1">
        <property type="nucleotide sequence ID" value="XM_009549832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K389"/>
    <dbReference type="GeneID" id="20668372"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_171926"/>
    <dbReference type="HOGENOM" id="CLU_2904447_0_0_1"/>
    <dbReference type="InParanoid" id="W4K389"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="62" mass="6894" checksum="205AD331A7A74899" modified="2014-03-19" version="1">MTVSIVKMSDLPAPVGVRIKVLCPSNILIVPLQYLDCGFDLPLPSVFGSQGHFSCFHFWWVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3V6</accession>
    <name>W4K3V6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_459262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547176.1">
        <property type="nucleotide sequence ID" value="XM_009548881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3V6"/>
    <dbReference type="GeneID" id="20676981"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_459262"/>
    <dbReference type="HOGENOM" id="CLU_314975_0_0_1"/>
    <dbReference type="InParanoid" id="W4K3V6"/>
    <dbReference type="OrthoDB" id="10671530at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="749"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="863"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="699"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="796"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="871"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="911"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="928" mass="99933" checksum="A00F0C9B8DAF0AEE" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4K418</accession>
    <name>W4K418_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_419680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548614.1">
        <property type="nucleotide sequence ID" value="XM_009550319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K418"/>
    <dbReference type="GeneID" id="20673588"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_419680"/>
    <dbReference type="HOGENOM" id="CLU_727731_0_0_1"/>
    <dbReference type="InParanoid" id="W4K418"/>
    <dbReference type="OrthoDB" id="3266192at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW80090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="380" mass="42460" checksum="86D4974CC8FA9F36" modified="2014-03-19" version="1">MRCACCYNLPSISGETGQILLFRCGPNGHRFDHGADRSLREDQRSFVVFAKLKDASLKGPRHTDPRAVEYYSALITDIDRYLDNNPGLDAFTATFTDFFIVGVGVLLHPPPNHRCSAGENEQRVKLLILAVQRAGGVSMLREKLTADQAKCITHYPPRQLALSVVSSLKPSHEGQRASKDYRTLVDDLVHATITSSYRHLNSSGGEPEHIAIELVKFCVKTGATSQFSYVVACLITPPPRMVISPDSLISFVRMLKQLLLLKTIDLAAEPWRRIFVATVEGFANKFMTPKPQELVPASQLQRVGCGCNECTELQNFFFGGKDVISLAKKKRARAHLVDRLSLTEAWGVKWETIEKGKREILRVIPLYLLPTQLVFRPINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4E5</accession>
    <name>W4K4E5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HETIRDRAFT_321057</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HRD1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547424.1">
        <property type="nucleotide sequence ID" value="XM_009549129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4E5"/>
    <dbReference type="FunCoup" id="W4K4E5">
        <property type="interactions" value="509"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K4E5"/>
    <dbReference type="GeneID" id="20670714"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_321057"/>
    <dbReference type="eggNOG" id="KOG0802">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009169_0_0_1"/>
    <dbReference type="InParanoid" id="W4K4E5"/>
    <dbReference type="OrthoDB" id="7759664at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16479">
        <property type="entry name" value="RING-H2_synoviolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
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        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058051">
        <property type="entry name" value="Znf_RING_synoviolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF184">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SYNOVIOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25563">
        <property type="entry name" value="TPR_SYVN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="321"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ETW80708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="384" mass="44616" checksum="460BEE78619C0F47" modified="2014-03-19" version="1">MSMMDILRPRLQSLAGTLVSHRVLLYTLSSTVAISVVIANALQIHSNFYSVTVYLSKSSRSILVLANFSLLVALVIGRIVQQIFFGSLRPLEVERLYDRMWFFVTESLLAFTIFRDEFDIPFAIMFGFLLFVKSFHWLMADRVEWMDQMPYPGPPALFHVRINSLFVLLWITNFVMLGFAVESILANGVGAMVLFASEYAILMASALNAMAKYALSIWEFRRAAYRGGENAPPWENKSMWVFYVDLMTDFLKLTTYLTFFTFILTFYGMPLNVVRDIYVTARSFITRLRTLIRYHNATRNMDERYPNATEAEMVEMSDRTCIICREEMIVRDTLRDDEHRDHPDTSDTPRDGPNITPKKLPCGHIFHFHCLRSWLERQQSCPTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4K541</accession>
    <name>W4K541_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_320170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ETW80859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009549263.1"/>
    </dbReference>
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        <property type="interactions" value="640"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K541"/>
    <dbReference type="GeneID" id="20670648"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_320170"/>
    <dbReference type="eggNOG" id="KOG1092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018687_5_0_1"/>
    <dbReference type="InParanoid" id="W4K541"/>
    <dbReference type="OrthoDB" id="26371at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="TBC1 domain family member 22A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000001">
        <property type="entry name" value="TBC1 domain family member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
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        <property type="entry name" value="LD44506P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="117"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW80859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="413" mass="48118" checksum="A905F39C1046BA77" modified="2014-03-19" version="1">MDPEFAETFVSTKSRQKPNTIREDAQEIVNGTSTRYSYCFQTLIQCLDPLHLVRRRTSKRPNAGSRSRSHSPAHGARSPERLIREHSIRTNRRHKFIECLMREDVDMAELRKLAWSGVPNELRPLAWQLLLGYLPLPTRLRSSTLERKRGEYLSLVGLTFARGREGLDQQIWHQIEIDVPRTRPGVQLWMYRATQRSLERILYVWAIRHPASGYVQGINDLVTPFFQIFLSAYIDSDPESFDPSLLPESVLDAIEADSFWCLSRLLDGIQDNYISAQPGIQRSVRRMSELVARIDAPLHEHLAAQNVEFIQFAFRWMNCLLMREISVKNTIRMWDTYLAEGPDAFSQFHLYVCSAFLVRWSEKLREMDFQGIIMFLQSLPTQDWTDHEIEMLLSQAFVLNSIWQNAQSHFTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4K579</accession>
    <name>W4K579_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_418528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547260.1">
        <property type="nucleotide sequence ID" value="XM_009548965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K579"/>
    <dbReference type="GeneID" id="20673484"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_418528"/>
    <dbReference type="HOGENOM" id="CLU_032924_0_0_1"/>
    <dbReference type="InParanoid" id="W4K579"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="487"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="100"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="500"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW80525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="520" mass="55639" checksum="54CFAD3731FE905D" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4K614</accession>
    <name>W4K614_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_46398</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546948.1">
        <property type="nucleotide sequence ID" value="XM_009548653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K614"/>
    <dbReference type="STRING" id="747525.W4K614"/>
    <dbReference type="GeneID" id="20677189"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_46398"/>
    <dbReference type="eggNOG" id="KOG1826">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="InParanoid" id="W4K614"/>
    <dbReference type="OrthoDB" id="10250725at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08217">
        <property type="entry name" value="STKc_Nek2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF10">
        <property type="entry name" value="NIMA-RELATED KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="8"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="316"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW81214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="352" mass="39910" checksum="B3BF31ED114719EC" modified="2014-03-19" version="1">MSSFLDLYEPLDIIGNGSFGIIRKVRRKSDGAILARKELNFERMSERDRKQIVAEVNILKDLNHEHIVRYHDRHVDRDAGILYILMEYCGGGDLSTLIKQSQKHGRPIPEDTIWNYFMQILLALHHCHHPNGHSRSGSSGEEGENGHRRAQILHRDLKPDNVFLDDANTVKLGDFGLSKALAQASFANTYVGTPYYMSPELMQEKAYDSKSDIWSLGCLIYELCALKPPFHEAKTHSELSVFIRNARIPPLPRGYSQALAGVIKAMLNLNPAMRPSAAQLLQHERLELSFKVFETQKMYVISPQSDARLSAAETLPSGSPPRNRTNCPSKRGSAIWPRGRRDVRLSNRNMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4K622</accession>
    <name>W4K622_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_433973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545936.1">
        <property type="nucleotide sequence ID" value="XM_009547641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K622"/>
    <dbReference type="GeneID" id="20674717"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_433973"/>
    <dbReference type="HOGENOM" id="CLU_2590051_0_0_1"/>
    <dbReference type="InParanoid" id="W4K622"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="85" mass="9540" checksum="93E5030188B2F696" modified="2014-03-19" version="1">MDSKAGARRAWARGDGRGLEGTRERTHAASDRRRRRRLRRGKLRLQHGDGALRGSLSGVELARGLEQRFEPGGNSINTLLRHGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>W4K691</accession>
    <name>W4K691_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_474728</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
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                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="14 15">TC 32-1</strain>
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    </dbReference>
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    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="1"/>
            <end position="28"/>
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            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="892" mass="99033" checksum="CD39C027E2CA9B2C" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6A3</accession>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
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                <person name="Raffaello T."/>
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                <person name="Salamov A."/>
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                <person name="de Vries R.P."/>
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                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">TC 32-1</strain>
        </source>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895:SF74">
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    </dbReference>
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    </dbReference>
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            <dbReference type="EMBL" id="ETW80606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="34439" checksum="CF6FD3420D6C0F5C" modified="2014-03-19" version="1">MPRYNAQHLLRALEAAIGRESARLEFKWMTQALSSAPPPYPMTRHAPIPDLPTMIARRVRGEPLQYILGTQPFGPLQHLRVRPPVLIPRPETEEWALRLSRMLAPSPRAPVRVLDLCTGTGCIPLLLCAQWPPGSTLAVGVDISTAALELAAENAAVCGVPTSTPAAADGPPHPPHPPTSTNVFIPFRGDLSDPDRLARALPFRPFHVLTANPPYIPRAEYDALPPSVRDFEDPAALLGDPPGAPDRRGLTFYHHIARALRSAGGRVLADGALVALEVGDGQARAVERILLDETPLRRTEVWEDAWGKERVVVARGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6Y4</accession>
    <name>W4K6Y4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_451350</name>
    </gene>
    <organism evidence="2 3">
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546233.1">
        <property type="nucleotide sequence ID" value="XM_009547938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6Y4"/>
    <dbReference type="GeneID" id="20676141"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_451350"/>
    <dbReference type="HOGENOM" id="CLU_2606325_0_0_1"/>
    <dbReference type="InParanoid" id="W4K6Y4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="79" mass="8729" checksum="957E5F9AF6DA9C7A" modified="2014-03-19" version="1">MHWAPPISIKASDFRYIQQNPATHRTATPICMHVHHGSATAAPRRGIKTRKNLDRDARMGTAATDVATDPEALDDPQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6Z3</accession>
    <name>W4K6Z3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Vacuolar fusion protein MON1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_417684</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 3">Prevacuolar compartment membrane</location>
            <topology evidence="1 3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vacuole membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MON1/SAND family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546210.1">
        <property type="nucleotide sequence ID" value="XM_009547915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6Z3"/>
    <dbReference type="STRING" id="747525.W4K6Z3"/>
    <dbReference type="GeneID" id="20673418"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_417684"/>
    <dbReference type="eggNOG" id="KOG0997">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014574_2_0_1"/>
    <dbReference type="InParanoid" id="W4K6Z3"/>
    <dbReference type="OrthoDB" id="272411at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043970">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004353">
        <property type="entry name" value="Mon1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027">
        <property type="entry name" value="SAND PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027:SF7">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN MON1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19038">
        <property type="entry name" value="Fuz_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01546">
        <property type="entry name" value="YEAST73DUF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="5">
        <location>
            <begin position="158"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="6">
        <location>
            <begin position="236"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 third Longin" evidence="7">
        <location>
            <begin position="404"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="92"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW81578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="518" mass="56670" checksum="C183F3F3AB16355A" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8J1</accession>
    <name>W4K8J1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CoA-transferase family III</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_418066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546670.1">
        <property type="nucleotide sequence ID" value="XM_009548375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8J1"/>
    <dbReference type="STRING" id="747525.W4K8J1"/>
    <dbReference type="GeneID" id="20673444"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_418066"/>
    <dbReference type="eggNOG" id="KOG3957">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021588_0_0_1"/>
    <dbReference type="InParanoid" id="W4K8J1"/>
    <dbReference type="OrthoDB" id="2308815at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050509">
        <property type="entry name" value="CoA-transferase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228:SF4">
        <property type="entry name" value="BLR3030 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228">
        <property type="entry name" value="SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="43788" checksum="A473AFD5704A0C9C" modified="2014-03-19" version="1">MLQPRSLTRYLHAIFSKANVTDSIYDSHKQGLVDILKCAPTKAAVAAALASWSSIDFEAEVMKRNLCAVAVRSFEEADRHPHARQTVNNESVYVRKIGDAPRRILSGTEFARALDGIRVLDLTRVLAGPVCGRTLAAHGADTLLVTSPNLPSLPLLDMDTSRGKRTTQLDLRDPKDKETLQSLVKDADVFLQAYRPGGLQGLGFGPEEVAKARPGIVYGTLSAYGFSGALKDAKGFDSLLQAIGGMNVAEAQAYKDYVLANGGNVNDFPPHRSLPMQALDHATGYLLAFGIISALCRTITEGGSYEVHVSLGATLHWVRSLGYLSPEEAYKNGEPLPPRGVPLDTEVAGFSTKIEQAVPDAGVQSGPVYHNITAIRHAAVMSKTKVCIGEAPMRLDAHLPVWLKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9A1</accession>
    <name>W4K9A1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_318381</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546834.1">
        <property type="nucleotide sequence ID" value="XM_009548539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9A1"/>
    <dbReference type="FunCoup" id="W4K9A1">
        <property type="interactions" value="369"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K9A1"/>
    <dbReference type="GeneID" id="20670506"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_318381"/>
    <dbReference type="eggNOG" id="KOG0706">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023062_7_0_1"/>
    <dbReference type="InParanoid" id="W4K9A1"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000004">
        <property type="entry name" value="Putative ADP-ribosylation factor GTPase-activating protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="10"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="194"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW82304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="476" mass="50366" checksum="FF2FD503CAA47E00" modified="2014-03-19" version="1">MAEPSKAETEQVFKVLKSGKGNKMCFDCQARNPTWSSVTFGVYICLDCSSVHRNMGVHISFVRSTNLDSWQLIQLRTMKIGGNGSATDFFTRHGGSTLLGESDVKKKYTSRVADLYKEELAKRVREDAAKYPEGIVVEGAETAKSPPTESTAGGDDDFFSSWDKPTSPKPAANSSKPAAPSVIGRAASASSAPRTVTSSSLRSTSTGSSVGRPARLGASRLSSSASTTSAASTAAPKKSKLGGLGAKKAAPVDFAEAERKATEEAERIKQLGYDQEREEQEERVKKEKEALELKSKAATVGVKTKTVEVAKVAPKPNGSSQDMERLGMGMKRLGFGGVPAAAAASSKASTSMVADDAPTTARDRFGGQKAISSDMFFGRNDYDASALSESRARLSQFQGATSISSNQYFGREEEDDLVAGNADGGLLGDGSLAGLETAAKEALARVMANPDVQNLGESIRTNALKLSDYLAQMSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-09-13" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9E3</accession>
    <name>W4K9E3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_173379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546318.1">
        <property type="nucleotide sequence ID" value="XM_009548023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9E3"/>
    <dbReference type="GeneID" id="20668441"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_173379"/>
    <dbReference type="HOGENOM" id="CLU_559040_0_0_1"/>
    <dbReference type="InParanoid" id="W4K9E3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="55054" checksum="2A800E4B9E1DA109" modified="2014-03-19" version="1">MLEKQGAFSFRRRISTARLVVRRVAAYNSSEPTSNRTTALRAPYLWTNVVLCSIPWKKIMLERSKGALIHFDFSTDFGETCVTLHTSLRLAMENLHRMRGLTLWGPIVPLLSDSDTPAPTLRILTLIYHVPVIDGRLPDSFFAHISPGLQELCLNGLGISPHSPLFGNMFTGLTSLTLIPCRVEHGWTLVQLLTVLERTPSLISLTLDEVLSILPDDLSLHSAVALNPVNLPHLQSLRFEHHRLVDCANLMHHLEIPPSTTINLSTIVTSRIALTLPQPVLPRRNLMYNAPGVPLPLHKFQIMHDDYNPAIQTTIYFSCSPTGNQEGMFSLHLEPEGFELSASDVVTVCKDLWLEDVHSLYLSIGRKSFDYATVFALFPAVDKLSVRHSAWHDIVKALASGSADGSDAVQLLCPHLRYLEFYCTKLDWLSRSIDVDENFFEMLATVLEVRRACGMELDRLLIFGEEILCREVADLRMLRKRKILKEYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4KA38</accession>
    <name>W4KA38_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_28205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544615.1">
        <property type="nucleotide sequence ID" value="XM_009546320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KA38"/>
    <dbReference type="STRING" id="747525.W4KA38"/>
    <dbReference type="GeneID" id="20669280"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_28205"/>
    <dbReference type="HOGENOM" id="CLU_164205_0_0_1"/>
    <dbReference type="InParanoid" id="W4KA38"/>
    <dbReference type="OrthoDB" id="3265515at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="95" mass="10995" checksum="ACD15444DCB53374" modified="2014-03-19" version="1" fragment="single">LTLQWVLGHIDIIGNKRSDKEVKAAVRGLTSMDTVLPKAIRGHLPFSWLAARQRFKDGLKKCWKKLMEQSPRWQKLQRIDPTAPSNRFRKITSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KA55</accession>
    <name>W4KA55_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_382709</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ETW82629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009546680.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
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        <property type="entry name" value="Rab-GAP-TBC_dom"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
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        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="1003"/>
            <end position="1191"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
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            <end position="426"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="448"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="575"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
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        <location>
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            <begin position="1"/>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="1268" mass="137179" checksum="9EFF789D0ADCD17B" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <text evidence="2">Belongs to the CIA30 family.</text>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
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    </dbReference>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW82878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="274" mass="30283" checksum="2B9796FDCF00CBD5" modified="2014-03-19" version="1">MSYLSTYLSRSSKILRDGTSRILRMQGAEAPSRAPLTLYTLNSREDLSHYATGCDADIGGTSSVHLDLDEDPAHNTSIGKPATAKFWGDMRLGVKAGLEGKLRGGYAGFRNRHRPTLFGELTDDVSQHHYLALRLRVAGHPRTRNSYFVNIQTDGPITSDLWQHRLYFSRTDGGWEDIFVPFNAFVLTNTGEIASDQISMLRERIRTIGISLLGGNSGVEGPYELGIDEIRAVNEEDVTVLPSRCLDPPHSRSALIWPAEIEPSTEGEGERGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KB11</accession>
    <name>W4KB11_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_408997</name>
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    <organism evidence="2 3">
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545311.1">
        <property type="nucleotide sequence ID" value="XM_009547016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KB11"/>
    <dbReference type="GeneID" id="20672744"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_408997"/>
    <dbReference type="HOGENOM" id="CLU_2794248_0_0_1"/>
    <dbReference type="InParanoid" id="W4KB11"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="68" mass="7294" checksum="D0946955566D5288" modified="2014-03-19" version="1">MSNADPVPPIESSSNTASHLLSNAHSLESKSPFLSGPPSDSDNDLNEQDDLGMFVSTGHALKKRRRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KB14</accession>
    <name>W4KB14_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_450637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545220.1">
        <property type="nucleotide sequence ID" value="XM_009546925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KB14"/>
    <dbReference type="GeneID" id="20676066"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_450637"/>
    <dbReference type="HOGENOM" id="CLU_799398_0_0_1"/>
    <dbReference type="InParanoid" id="W4KB14"/>
    <dbReference type="OrthoDB" id="2742220at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW82914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="405" mass="44931" checksum="E266724D7403D0F0" modified="2014-03-19" version="1">MVEVQDLAMMLADRQALDRSMHVLSGLYIWEFFMTFDYEWALYRRRMPFKWTMLLYIGSRWLTLVFVVCVFILFDRATEMDCDAVFKLLIATSYSALICTSAMSVLRAIAIWRFATAVVVATASIQLLDVAWGIIALTVAGITRARAAWDPELGLCVVKDTALQRDTMLVDLACQLSLLVIMFVGVLRMRAENGLWRVLYHQGMLCLLLAVLALVPSNTLLILNLNGQGDLPFSTTARADLFAHCLLGALDAEVLGTDFADPAPYDHGDQHSAHLSLAERVLRAGARPVRPAPSDHSHRITFPRSTTVTTLDFRTMASMVDGAQTQTLDLPGAHERRKSNLDRRLGAQHGGSPFASLSAVGSDKPPDVEARGAAEPWRRRNVCVQVGAGEESFGVDFVDEWRRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W4KB64</accession>
    <name>W4KB64_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TRX8_PDI</name>
        <name evidence="12" type="ORF">HETIRDRAFT_148540</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545328.1">
        <property type="nucleotide sequence ID" value="XM_009547033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KB64"/>
    <dbReference type="FunCoup" id="W4KB64">
        <property type="interactions" value="204"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KB64"/>
    <dbReference type="GeneID" id="20667276"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_148540"/>
    <dbReference type="eggNOG" id="KOG0191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038617_1_1_1"/>
    <dbReference type="InParanoid" id="W4KB64"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00238">
        <property type="entry name" value="ERp29c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02998">
        <property type="entry name" value="PDI_a_ERp38"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1150.12">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011679">
        <property type="entry name" value="ERp29_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036356">
        <property type="entry name" value="ERp29_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF11">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07749">
        <property type="entry name" value="ERp29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47933">
        <property type="entry name" value="ERP29 C domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005715675" description="protein disulfide-isomerase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="130"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW83043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="369" mass="40128" checksum="9054B22C5908FAF9" modified="2014-03-19" version="1">MRLLSLFPLALATAAYASNVLDLIPDNFDNVIGKGKPGLVEFFAPWCGHCKNLAPTYEQLADAYSHAKDKVVIAKVDADGAGRPLGQKYGVTGYPTLKWFDADGTATPYEGGRDLDALTSFISSKTNVKSNIKPPPPPSTLILDTHTFDDVALNADKDVIVTFTAPWCGHCKNLKPIYEHVAEDFLSESNCIVANVDADAEANRPLALKYGIQSFPTIKFFPKGSGEPEDYTGERTEQAFVDFLNEKCGTQRAVGGGLNEKAGRWPELDSLASKFLVSTGEARDAVFKEASLLSGSVGPSAKHYLRVMEKVVNGTEDYITKESRRLSSILSKRTLSAAKLDEIKIKANVLSAFKAENVEAKIERATEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KB97</accession>
    <name>W4KB97_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_107144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545291.1">
        <property type="nucleotide sequence ID" value="XM_009546996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KB97"/>
    <dbReference type="STRING" id="747525.W4KB97"/>
    <dbReference type="GeneID" id="20666217"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_107144"/>
    <dbReference type="HOGENOM" id="CLU_2498138_0_0_1"/>
    <dbReference type="InParanoid" id="W4KB97"/>
    <dbReference type="OrthoDB" id="407198at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW82999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="86" mass="10257" checksum="D9CA065F06E1449D" modified="2014-03-19" version="1">MRGASEHLRKWQQRQWRTRERESVKNKDLWEILLHGLEKWEKFDVSVQFLLVRREQNAQAMDAAKRGALSEDNRSSCFRKVIAVAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBA1</accession>
    <name>W4KBA1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_459191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546848.1">
        <property type="nucleotide sequence ID" value="XM_009548553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBA1"/>
    <dbReference type="GeneID" id="20676976"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_459191"/>
    <dbReference type="HOGENOM" id="CLU_532156_0_0_1"/>
    <dbReference type="InParanoid" id="W4KBA1"/>
    <dbReference type="OrthoDB" id="3232239at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="58972" checksum="38EF34BAA70CE494" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBN6</accession>
    <name>W4KBN6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Multicopper oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">HaMco1</name>
        <name evidence="12" type="ORF">HETIRDRAFT_119423</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545533.1">
        <property type="nucleotide sequence ID" value="XM_009547238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBN6"/>
    <dbReference type="SMR" id="W4KBN6"/>
    <dbReference type="STRING" id="747525.W4KBN6"/>
    <dbReference type="GeneID" id="20666647"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_119423"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_7_1_1"/>
    <dbReference type="InParanoid" id="W4KBN6"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13857">
        <property type="entry name" value="CuRO_1_Diphenol_Ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13883">
        <property type="entry name" value="CuRO_2_Diphenol_Ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF414">
        <property type="entry name" value="ADR239WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845355" evidence="8">
        <location>
            <begin position="21"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="118"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="245"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="516"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW83262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="674" mass="72079" checksum="73727CFAE87AF2E4" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCP0</accession>
    <name>W4KCP0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_449311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543405.1">
        <property type="nucleotide sequence ID" value="XM_009545110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCP0"/>
    <dbReference type="FunCoup" id="W4KCP0">
        <property type="interactions" value="384"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KCP0"/>
    <dbReference type="GeneID" id="20675936"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_449311"/>
    <dbReference type="eggNOG" id="KOG0089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031413_0_1_1"/>
    <dbReference type="InParanoid" id="W4KCP0"/>
    <dbReference type="OrthoDB" id="41403at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004487">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01079">
        <property type="entry name" value="NAD_bind_m-THF_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000401">
        <property type="entry name" value="Related to MTD1-methylenetetrahydrofolate dehydrogenase (NAD+)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035812">
        <property type="entry name" value="m-THF_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="1">
        <location>
            <begin position="17"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="2">
        <location>
            <begin position="188"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW83632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="39113" checksum="6CD4898DC5CD2A01" modified="2014-03-19" version="1">MSSDPAHAAAPKGLLLKADTIAAPFQAEVQHALAARPRAPKLVGILATSSAPSRSYAEFTRRQCAALGFEFVLREVGAACAPAEEGGERGGEGEGVEDAIIEANADESVDGIMVYYPIFGAQQDHYLQQVVSPFKDVEGLNFKFHYNLYHNIRYLDPNSLLSSAPLTNVPSAKTEDVPPEGTVKSILPCTPLGIVKCLENIGVYNRILPYGDRAYGKTVTVINRSEVVGRPLAALLANDGARVFSVDIDSIQEYTKRPPSSTRRYHPHHVVHPSTLTLEACLAQSDVVVSAVPSAAYKVRTAWLKDGCVCVNVAADKNFEADVREKASLYVPAVGKVTILMLLRNLLRLQEYQDLLVKSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDD4</accession>
    <name>W4KDD4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_311858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543599.1">
        <property type="nucleotide sequence ID" value="XM_009545304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDD4"/>
    <dbReference type="STRING" id="747525.W4KDD4"/>
    <dbReference type="GeneID" id="20669906"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_311858"/>
    <dbReference type="eggNOG" id="ENOG502QS3W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048934_1_0_1"/>
    <dbReference type="InParanoid" id="W4KDD4"/>
    <dbReference type="OrthoDB" id="10253744at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF14">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="303" mass="33038" checksum="404A2A921954B20F" modified="2014-03-19" version="1" fragment="single">ALSTLFPIKVVISTGKSDWERSVTDVKGSLAAHLLAVDSGTAPCSASTSTSGTSTPGTPGSTLRGFEPTAVTGIFKDSETRKVSILNGSHDTLSAASDVETVLVFPDYKLVTEVPCSLDGARELWDHSVDPSVPRLGSSLVLGPLKSWIIPYSCVILICSHRRRDVRCAVVAPKLEHAFSEALHREGWDVHTQLEEPTGPSLEDFNHSDEDKEAEMQRRLQELDEDIHKKALILKTSHIGGHKYAGNVIIYMPQGSGVWYGRVSTHEVYPIVQNTILGGRILPPLLRGGVNLSRPDCKRLNDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDE5</accession>
    <name>W4KDE5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_443938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543517.1">
        <property type="nucleotide sequence ID" value="XM_009545222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDE5"/>
    <dbReference type="GeneID" id="20675551"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_443938"/>
    <dbReference type="HOGENOM" id="CLU_990644_0_0_1"/>
    <dbReference type="InParanoid" id="W4KDE5"/>
    <dbReference type="OrthoDB" id="3268221at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="281" mass="29201" checksum="709A9A7E52D0CBF6" modified="2014-03-19" version="1">MEPETAPSPSLNGELPPGFIPMGPPVSAPTPSQSSRTMSAYTGAGVPLPPSATSTFYQLPSEPGLRAGRGTSSVSGMSGGQPTSRSRRSRNGGSTSDPVMIPLPPTVASSSIVLPPPDLLSRPHGDSTSSTSTTSEDEAVRSSIASSSADTLTTPPMRNRKTLSKARNPAYDAAPVPTGFEYPATPSVRNSTPGNAARVPLPPSTTAGTPRTTSAFTPHRSGANINAGMTPGVRHSSLRSGGREPKVHHRHSYKRFDSNAYLDPAYLASSDDLHETDDSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFM6</accession>
    <name>W4KFM6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_439293</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544289.1">
        <property type="nucleotide sequence ID" value="XM_009545994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFM6"/>
    <dbReference type="FunCoup" id="W4KFM6">
        <property type="interactions" value="164"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KFM6"/>
    <dbReference type="GeneID" id="20675124"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_439293"/>
    <dbReference type="eggNOG" id="KOG4203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067096_1_1_1"/>
    <dbReference type="InParanoid" id="W4KFM6"/>
    <dbReference type="OrthoDB" id="106623at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000023">
        <property type="entry name" value="Probable uracil phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW84648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="222" mass="24476" checksum="4E13DEB75DD92E89" modified="2014-03-19" version="1">MSAPAKPAYTPPSSVITLTPTAQLEALYTIIRNKDTPRGDFLFYSDRIIRLLVEEGLNHLPVVPKTVETPTGATYEGVGFEGKICGVSILRAGEAMEAGLREVCRSVRIGKILIQRDEETTLPKLFYSKLPQDISSRYVLLLDPMLATGGSAMKAVEVIMEHGVPEERIIFINLIASPEGLNTFCKKYPALRVITGWIDDGLNEKAYIIPGLGDFGERRYCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFS6</accession>
    <name>W4KFS6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative lipoate-protein ligase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_314337</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LplA family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543866.1">
        <property type="nucleotide sequence ID" value="XM_009545571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFS6"/>
    <dbReference type="FunCoup" id="W4KFS6">
        <property type="interactions" value="261"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KFS6"/>
    <dbReference type="GeneID" id="20670115"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_314337"/>
    <dbReference type="eggNOG" id="KOG3159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022986_3_1_1"/>
    <dbReference type="InParanoid" id="W4KFS6"/>
    <dbReference type="OrthoDB" id="201621at2759"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017118">
        <property type="term" value="F:lipoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16443">
        <property type="entry name" value="LplA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00545">
        <property type="entry name" value="lipoyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="LIPOATE-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561:SF3">
        <property type="entry name" value="LIPOYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="5">
        <location>
            <begin position="55"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW84165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="372" mass="42075" checksum="B11B888331FC14C1" modified="2014-03-19" version="1">MTIRPSRNFRYACTSRVFATSQTRSLSSHHSIYVSNSVNPCFNLTLEDWLFKHKSHKEPLLLLYRDDPCVVIGRNQNPWKEVNFPALQRADIPFIRRRSGGGTVYHDSGNTNFSIHLPRSQFDRNSTGQVVLRAVRALGIDARLNDRNDLCVGPYKISDFYYTSSYCQHDCLYVSGSAYKIVKDRAYHHGTMLISSQLNTLGDVLHSTKTSMATKGVASVRSPVRNLNEFRPDISHEDFVDALTRAFREHYGVDKPVCIMTGDTNDMNVDEIRSGMAELLSWDWAFGQTPEFTYSIRGQFAWGNVAAEIRSKHGVILSCTLTPDDTTLSKNLDKLGVVLEGQKYGSVCSDLLGSAEQRLRDVAVWLEREMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFS8</accession>
    <name>W4KFS8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_171200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544335.1">
        <property type="nucleotide sequence ID" value="XM_009546040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFS8"/>
    <dbReference type="GeneID" id="20668321"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_171200"/>
    <dbReference type="HOGENOM" id="CLU_2413517_0_0_1"/>
    <dbReference type="InParanoid" id="W4KFS8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW84698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="92" mass="10625" checksum="4439ED440D67EDCE" modified="2014-03-19" version="1">MHSADHALIRSTREDILSTERPLFILTLSRAIIVSETFVISLAGFSQRQWVWTLELHPIRIENAVRVFSHSGQPRSLPRRNHADPFNRCCSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4KG41</accession>
    <name>W4KG41_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_312380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544341.1">
        <property type="nucleotide sequence ID" value="XM_009546046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KG41"/>
    <dbReference type="STRING" id="747525.W4KG41"/>
    <dbReference type="GeneID" id="20669950"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_312380"/>
    <dbReference type="eggNOG" id="ENOG502SUBD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026252_1_0_1"/>
    <dbReference type="InParanoid" id="W4KG41"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050667">
        <property type="entry name" value="PPR-containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47939">
        <property type="entry name" value="MEMBRANE-ASSOCIATED SALT-INDUCIBLE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47939:SF13">
        <property type="entry name" value="OS03G0201400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="595"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW84704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="626" mass="69579" checksum="4BCE72BF7BFD66BD" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4KG98</accession>
    <name>W4KG98_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_312536</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544484.1">
        <property type="nucleotide sequence ID" value="XM_009546189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KG98"/>
    <dbReference type="STRING" id="747525.W4KG98"/>
    <dbReference type="GeneID" id="20669967"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_312536"/>
    <dbReference type="eggNOG" id="KOG0502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_18_0_1"/>
    <dbReference type="InParanoid" id="W4KG98"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="234"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW84857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="314" mass="34068" checksum="44CF97FE47C12924" modified="2014-03-19" version="1" fragment="single">QGGNYGNALYAASYNGHEAIVKLLLDRGVEVNARGGDCLNALYTASYNRHKAIVQLLDRGAELNAQEGLYGKALQVASYNGHDAVAQLLLDRGAELDVQGGYYGNALQTASHNGHDAVVRLLLDRGAEVNEQGGYYGNALQTASHNGQRAIVQLLLDRSADANSQEGDYSDMLQVVSHEGYEAIVRLLLDRGTEVNAQGGDYGHALQAVSYSRSEAITQLVLDQGAEINSRGGRYSNALQAASCRSREAIVRLLLNRGAEVNTQEGHYGNAVEAAYNSRNRTPIQLLLDKDAWRKQWNGIRKLCMHQEKGALLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KH91</accession>
    <name>W4KH91_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_439169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544086.1">
        <property type="nucleotide sequence ID" value="XM_009545791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KH91"/>
    <dbReference type="GeneID" id="20675112"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_439169"/>
    <dbReference type="HOGENOM" id="CLU_1635616_0_0_1"/>
    <dbReference type="InParanoid" id="W4KH91"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="162" mass="17690" checksum="64959DAB4A8EF9D7" modified="2014-03-19" version="1">MHPGRERREEGLQVLLRGGRLPAVFRGKRERAQRALLRAADKKRDGPAQRAAVQEDDQAADTAPRGRASRAGRGGAGRRVRHGDTQRVDGALQGVFGPIWTTLRGAVRGRQTRLKYLGLDARIWNFLIAIASGQRPSACRAGMFGMTPPAADWMTAAGERGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHT2</accession>
    <name>W4KHT2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bacteriophage T5 Orf172 DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_311200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542276.1">
        <property type="nucleotide sequence ID" value="XM_009543981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHT2"/>
    <dbReference type="STRING" id="747525.W4KHT2"/>
    <dbReference type="GeneID" id="20669848"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_311200"/>
    <dbReference type="eggNOG" id="ENOG502QWMU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020641_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHT2"/>
    <dbReference type="OrthoDB" id="2417614at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053006">
        <property type="entry name" value="Meiosis_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10544">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacteriophage T5 Orf172 DNA-binding" evidence="2">
        <location>
            <begin position="157"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW85413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="324" mass="36895" checksum="A269344C2E9DB84F" modified="2014-03-19" version="1">MYHALNPSLELKVPPPPSTPPRLYSDPVAQLSVTALTQTPQSASAKTPQSASTKTPRSSRRKRESSAGVEGEDYVPCNGITLRGQKCTRKVKRSLYQDVAFCYQHSDTLLERVKFTSPKTGESVRFQDWIPDYLHRSTQISLRAEMTKTRSDSDEDGYIYAYEIEKLGLDSNQIHIKVGRTTVLNNRIDQWNKQCNSTEPNLLGWWPDGTHSDTVIRLMAGRVEAGRKGALCHRLERLVHIELFDLAARNLHLDPAFPGDVDPDKIDDSDFFNRSRKTCIDCGRVHKEIFSFARAQDGPYKRKEWDLIVKPVIEKWGSFVEQFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHZ4</accession>
    <name>W4KHZ4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_382351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544338.1">
        <property type="nucleotide sequence ID" value="XM_009546043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHZ4"/>
    <dbReference type="GeneID" id="20672114"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_382351"/>
    <dbReference type="HOGENOM" id="CLU_2558550_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHZ4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW84701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="74" mass="7562" checksum="AC856CF4E5752FA7" modified="2014-03-19" version="1">MPSWLSSPPLGAACAALHTGGPARASVGSRCKTLSACRVRSGPTVPRLGKGGWYWSRCLRGRVTAPGGPTLVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIF9</accession>
    <name>W4KIF9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_236485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542484.1">
        <property type="nucleotide sequence ID" value="XM_009544189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIF9"/>
    <dbReference type="GeneID" id="20668760"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_236485"/>
    <dbReference type="eggNOG" id="ENOG502SKH3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010273_0_0_1"/>
    <dbReference type="InParanoid" id="W4KIF9"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="694" mass="78275" checksum="474F26A4A626144D" modified="2014-03-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIZ8</accession>
    <name>W4KIZ8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_414792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIZ8"/>
    <dbReference type="GeneID" id="20673202"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_414792"/>
    <dbReference type="HOGENOM" id="CLU_2942015_0_0_1"/>
    <dbReference type="InParanoid" id="W4KIZ8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="60" mass="6739" checksum="59960FEB9286CBB5" modified="2014-03-19" version="1">MPCKHCLAIYSCQSSLSNIYLSQGLAKTPRNMKIAFLLVPHMLMQYPPSQLEVLVGFRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
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    <name>W4KJ73_HETIT</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="1" type="ORF">HETIRDRAFT_115444</name>
    </gene>
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            <taxon>Agaricomycotina</taxon>
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            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="20666482"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_115444"/>
    <dbReference type="HOGENOM" id="CLU_1749897_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJ73"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="149" mass="17000" checksum="B8AAA6B2C598AEDD" modified="2014-03-19" version="1">MTLNYARDIYAKYILQAYQTCFNTGSHQVIPNTEHPLMNFFSSVVSGTAEDIDRWKRYTTLPARSLRIWQNLRSHPSVFEDVHVPKESKQKYMCSTSFNERLQTDLEQLISAVPLHIGPFPQAAFLVAQQQTSILPNPRGSGSAKRQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
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            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
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    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
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                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009544470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJD3"/>
    <dbReference type="GeneID" id="20666778"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_122310"/>
    <dbReference type="HOGENOM" id="CLU_2454995_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJD3"/>
    <dbReference type="OrthoDB" id="200924at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="89" mass="10010" checksum="3DE15E8852E8AF9C" modified="2014-03-19" version="1">MTRWPVIRCDAVAGSPVPSLRHEAPRPKPVGNALMPMISFLALLKPRDLVLTIAGASCPHYFRLHFLFSARRPWRMAYQRGPTAPNLDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJN7</accession>
    <name>W4KJN7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_240127</name>
    </gene>
    <organism evidence="9 10">
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009544559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJN7"/>
    <dbReference type="GeneID" id="20668843"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_240127"/>
    <dbReference type="eggNOG" id="ENOG502S27S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037802_1_0_1"/>
    <dbReference type="InParanoid" id="W4KJN7"/>
    <dbReference type="OrthoDB" id="10254418at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046513">
        <property type="entry name" value="DUF6691"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp_TsuA/YedE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YEDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574:SF1">
        <property type="entry name" value="SULPHUR TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20398">
        <property type="entry name" value="DUF6691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW86073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="318" mass="32875" checksum="8E5F8285A8B8D3E9" modified="2014-03-19" version="1" fragment="single">MATGSTPLQSFLGGIGLALPVHTLLMLNGSVFGIAGFLHRAVKGGMEDAASVLGLLLGGIVVGAIEGPGPQMSEASSSTMIASGVLVGLGTKLSNGCTSGHMICGLSRLSPRSIVATATFFITGVLTTHVLHSSRLIAAGPADYTLGDHGTTFMIGSSVSMLSALVVQYLLSPPDSVDMPKIYDETYSHRRIVTSFLTAVSFSLALRLSNLTSPQRVLSFLILPFNSSFDPSLAFLAVGALPLASALYRKWGRGLCPKTSAKVDWRLVTGAAVFGVGWGMEGICPGPGLVNFGRALATSSNIQPLAIWLVSVLVGGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJP1</accession>
    <name>W4KJP1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_122344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542720.1">
        <property type="nucleotide sequence ID" value="XM_009544425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJP1"/>
    <dbReference type="GeneID" id="20666781"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_122344"/>
    <dbReference type="HOGENOM" id="CLU_2722534_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJP1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="72" mass="7477" checksum="0B7EF4C05E76E8C0" modified="2014-03-19" version="1">MSLLRANPFPHSSHPCCCCCCCCPFSTGPATSPPRFFRPCDLLAVDTLPTAAAAPAVDVDACGCCVCKAVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KK01</accession>
    <name>W4KK01_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NECAP PHear domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_407887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542943.1">
        <property type="nucleotide sequence ID" value="XM_009544648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KK01"/>
    <dbReference type="STRING" id="747525.W4KK01"/>
    <dbReference type="GeneID" id="20672637"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_407887"/>
    <dbReference type="eggNOG" id="KOG2500">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069884_2_1_1"/>
    <dbReference type="InParanoid" id="W4KK01"/>
    <dbReference type="OrthoDB" id="10265489at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13228">
        <property type="entry name" value="PHear_NECAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012466">
        <property type="entry name" value="NECAP_PHear"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847">
        <property type="entry name" value="ATP-BINDING CASSETTE ABC TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847:SF9">
        <property type="entry name" value="NECAP-LIKE PROTEIN CG9132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07933">
        <property type="entry name" value="DUF1681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NECAP PHear" evidence="2">
        <location>
            <begin position="9"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW86177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="219" mass="24035" checksum="EFEFA89190CEB892" modified="2014-03-19" version="1">MDDLTNDEIESILYIAREISVYKIPPLKKNEGHRAQDWGDLAQPLWKGRMRIVEKSEAVSLLFEDVTTGELFAKASYDAAKPPVEAVLDSSRYFVVRVEDSGRKAYIGMGFAERSDSFDFNVALQDYTKRYKARLNPPSPTSEDQPSPHIPAGPKKDYSLKEGQTFSISIPGRGNKLDTSKTGLLETNLLGSGTTVSSTNSGGGGFPLLPPPPSAPKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W4KK15</accession>
    <name>W4KK15_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Tubulin gamma chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_150132</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542505.1">
        <property type="nucleotide sequence ID" value="XM_009544210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KK15"/>
    <dbReference type="FunCoup" id="W4KK15">
        <property type="interactions" value="317"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KK15"/>
    <dbReference type="GeneID" id="20667353"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_150132"/>
    <dbReference type="eggNOG" id="KOG1374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015718_1_0_1"/>
    <dbReference type="InParanoid" id="W4KK15"/>
    <dbReference type="OrthoDB" id="10249382at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000004">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000003">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000012">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="10">
        <location>
            <begin position="48"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="11">
        <location>
            <begin position="248"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW85670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="454" mass="50895" checksum="5780808035C6D296" modified="2014-03-19" version="1">MPREIVTVQIGQCGNQMGSVFWQRLCAEHGINKEGILEEWATEGGDRKDVFFYQADDEHYIPRAILVDLEPRVINNIITSPYANLYNPENIFVSKDGGGAGNNWAQGYSAGERLYEDIMEMVDREAEGSDSLEGFMMLHSIAGGTGSGLGSFLLERLNDKFPKKLIQTYSVFPNAQEGDVVVQPYNALLTLKRLTNHADSVVVLDNGALARINADRLHTSTPSFDQTNQLVSTVMAASTQTLRYPGYMNNDLVGIIASLIPTPRCHFLMTSYTPFTSDNIDKAKPIRRTTVLDVMRRLLQPKNRMVSTTPSKTACYISILNIIQGDVDPTDVHQSLLRIRERQLANFIPWGPASIQVALTRRSPYVTTNHRVSGLMLANHTSIASLFKRMLDQFDRLRKRNAFLEQYKKEKMFENGLEEFDDARATAEELLKEYKACESPDYISYGAADGDQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKH9</accession>
    <name>W4KKH9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear speckle splicing regulatory protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_310082</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NSRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542661.1">
        <property type="nucleotide sequence ID" value="XM_009544366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKH9"/>
    <dbReference type="FunCoup" id="W4KKH9">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KKH9"/>
    <dbReference type="GeneID" id="20669744"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_310082"/>
    <dbReference type="eggNOG" id="KOG2117">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042321_1_0_1"/>
    <dbReference type="InParanoid" id="W4KKH9"/>
    <dbReference type="OrthoDB" id="446635at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053246">
        <property type="entry name" value="NS_splicing_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018612">
        <property type="entry name" value="NSRP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47845">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47845:SF1">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09745">
        <property type="entry name" value="NSRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear speckle splicing regulatory protein 1 N-terminal" evidence="4">
        <location>
            <begin position="67"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW85845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="382" mass="43657" checksum="66AC2788BD81D425" modified="2014-03-19" version="1">MKLSFSLANKSKEKPVGVAPSLKRSAAFASIDDDATEDAPHTTSSTSKGVTNRRLIAQNVEMSKTAKKRMEAEKQVDSTVFEYDEVWDHMQESKLRQKEVKEQESKERKPKYISNLLNSAETRRLDHLRAEEKMIQREREAEGDEFMDKEAFVTQAYKDQMAEVRRAEEEEKQREGMPLEKKKGSSSGMAHFYRKMLEESEQKHEETVAATLQAQKKKIQGPQGPAPNLTITKPINFIPQSDLELARLAKAQGKDVELNDDNQIVDKRDLLSAGLNLSAPNTRLLGLRTSVKKVDTEKVEVHRAAGTAASRQEINQRRKKEIFAQMEDEQHRILKEKQQREEEAAARLIARRNDDEAIQSAVERYRQRKRQKLEQAASEGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKR8</accession>
    <name>W4KKR8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_406534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540442.1">
        <property type="nucleotide sequence ID" value="XM_009542147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKR8"/>
    <dbReference type="GeneID" id="20672522"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_406534"/>
    <dbReference type="HOGENOM" id="CLU_2922868_0_0_1"/>
    <dbReference type="InParanoid" id="W4KKR8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="61" mass="6937" checksum="B9CA1B9D20BCAA55" modified="2014-03-19" version="1">MLVRGDAARQERMNRNHGSNKDVSIRLHIRAVLRGWKEYTDEIEFIGDGTKVTVRSEAPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKS6</accession>
    <name>W4KKS6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_310875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543044.1">
        <property type="nucleotide sequence ID" value="XM_009544749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKS6"/>
    <dbReference type="STRING" id="747525.W4KKS6"/>
    <dbReference type="GeneID" id="20669810"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_310875"/>
    <dbReference type="eggNOG" id="ENOG502RCYW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021768_8_2_1"/>
    <dbReference type="InParanoid" id="W4KKS6"/>
    <dbReference type="OrthoDB" id="5404599at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="126" mass="15173" checksum="5327815923EE50CF" modified="2014-03-19" version="1" fragment="single">GPFRSVEEFHGQLIARACSEWPEDQSDLIWHKIRQVHPRPHRMVLTYNDLGPHNILVDNNLHITRIVDWEVAGCLPEYWCFTKATYLPVYCIPQGNWLALMLQVFPQYSDEREAERYLWKYRLRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKW5</accession>
    <name>W4KKW5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine transaminase</fullName>
            <ecNumber evidence="4">2.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_44105</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-(phosphooxy)-L-threonine + 2-oxoglutarate = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-serine + 2-oxoglutarate = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="4"/>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541802.1">
        <property type="nucleotide sequence ID" value="XM_009543507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKW5"/>
    <dbReference type="FunCoup" id="W4KKW5">
        <property type="interactions" value="406"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KKW5"/>
    <dbReference type="GeneID" id="20675322"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_44105"/>
    <dbReference type="eggNOG" id="KOG2790">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034866_0_0_1"/>
    <dbReference type="InParanoid" id="W4KKW5"/>
    <dbReference type="OrthoDB" id="1703350at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000010">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000006">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003764">
        <property type="entry name" value="PRK05355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247:SF1">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="12">
        <location>
            <begin position="6"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW85995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="404" mass="44077" checksum="E53FF5CCFE22D7AF" modified="2014-03-19" version="1">MATSRVVNFGAGPSALPASVLEQAAQSLMDFQGTGIGIAEISHRSKEFTSFLTGLESRIRAQLSVPPTHSILFTQGGGSAQFSAVVYNLLARHRLLHPELTDEQRTMDYVVTGSWSKKAVEEARRLGGGAVNVVVDARKYSKDGKSFDNIPPHSEYTFSPDPALIYYCENETVDGVEFSHDEAAPTSFPYQLLKKGALLPLVADYSSSFMCRPIPNLADHAVIFAGAQKNIGPAGLTILIVRQDCLVDTDAAAKIGAAPVPLTMSYKTLADSKSLYNTPSVLPLYISGLVLERMERLGGIKYYEELNRRKSGKVYAVLKEGEEKGVFQKKVQDGSESWMNVVFTSPKEGSEQRFLDGAEKEGMKGLKGHRSVGGIRVSLYNAVTEEETDKLVSYMKEFIAQEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLF5</accession>
    <name>W4KLF5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_43527</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CKS family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541784.1">
        <property type="nucleotide sequence ID" value="XM_009543489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLF5"/>
    <dbReference type="FunCoup" id="W4KLF5">
        <property type="interactions" value="235"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KLF5"/>
    <dbReference type="GeneID" id="20674813"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_43527"/>
    <dbReference type="eggNOG" id="KOG3484">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140546_1_2_1"/>
    <dbReference type="InParanoid" id="W4KLF5"/>
    <dbReference type="OrthoDB" id="440676at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00296">
        <property type="entry name" value="CYCLINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00945">
        <property type="entry name" value="CKS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW86190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="103" mass="12094" checksum="F3E4429E55D5DA64" modified="2014-03-19" version="1" fragment="single">SDDEYEYRHVILPKPLFKLIPKQYFNADDSGTLRLLTEPEWRGIGITQSLGWVHYEVHAPEPHVLLFRRLKNFDQQYAQQQAYEQQQQLANGKIAAGRNGRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLN4</accession>
    <name>W4KLN4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_413020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540622.1">
        <property type="nucleotide sequence ID" value="XM_009542327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLN4"/>
    <dbReference type="GeneID" id="20673086"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_413020"/>
    <dbReference type="eggNOG" id="ENOG502S3JP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090055_0_0_1"/>
    <dbReference type="InParanoid" id="W4KLN4"/>
    <dbReference type="OrthoDB" id="2107166at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="124"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW86619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="172" mass="19371" checksum="22867D496E29733C" modified="2014-03-19" version="1">MGRWTQYDEDDYRLPDGMKRVGYDSDTGKYYFRDRDGSLWEGSEYGEMQRGTNNNDVEIGPDGYIPLAEDADQPPRPKLSSNDSPYRMLFPFFLIVIVVLLLVWRLIVAPANSRPVLTCPEHSTSSVIVFGDTCWAIAQAHGCVVDDILRLNPKLNCDVLRPGARICIPSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLX0</accession>
    <name>W4KLX0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_438585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542843.1">
        <property type="nucleotide sequence ID" value="XM_009544548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLX0"/>
    <dbReference type="GeneID" id="20675057"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_438585"/>
    <dbReference type="HOGENOM" id="CLU_921528_0_0_1"/>
    <dbReference type="InParanoid" id="W4KLX0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW86061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="302" mass="33949" checksum="4594DA1FC49DDAC1" modified="2014-03-19" version="1">MSDNHTLVHGTTVKTGIDSISSASRSKAKQTPQSSADPEQTNKRKRKAAADGAEPARPERKRRTNPRASDVAATRSIGPITSSVVEEEHEARRTVDDSIPIYLDKLIEKVQDLEALVEHQNKELRALKSQLSRMEKSHSENFHRLLKLYEDRQDAPPNAQQPRAPPPRTLGQFTPNYHSDRGGPNWQPPADDQSVYAFDGSPQRYAQRQSPADNHQHPNILEPSEPMRAPPHPFPHRGRGFGRGRGRGAFRQQPRQSPYHQDLAHAAPDTDYRAQPSRRGYGDSSHTPPRLPYSQYNGTWPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KM04</accession>
    <name>W4KM04_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_443744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542867.1">
        <property type="nucleotide sequence ID" value="XM_009544572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KM04"/>
    <dbReference type="GeneID" id="20675539"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_443744"/>
    <dbReference type="eggNOG" id="ENOG502SQ5R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060356_2_0_1"/>
    <dbReference type="InParanoid" id="W4KM04"/>
    <dbReference type="OrthoDB" id="3237202at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR EAF N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="8"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW86091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="360" mass="40486" checksum="2384AFA795B2344B" modified="2014-03-19" version="1">MLNYRGYEAWITSDGQKLPEYEISIDTEKHRATCWIAGQEGKEFIVNWRDLGGKVDTMSYITLDGFTVPGRFLYGDGISNRAGVRTSPSKERPFVFAKVDEEADIIETDADPKQLGMIILRIRRIRRIGGHMPNTPRPIPNLMRGREKYYEMRAGFGKETTTHPQIPVTFSIEPFDKANPGSYVTFIFRYRTKEFLEAQGIKPSDSGWTSHKKTVSVQALKTAQPSQIPTKTQLSNLPFLETMVAEPALKSEPHQTPYASLTWLPGETGEMPEHPRAVSVPLTPDPSPKISGTKRLRQVVSTFTPQKARRTNSQSIASSRRSHDEADDDFPSKKEKSLDLTSNNNKSPSDMVDDNPPQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMD6</accession>
    <name>W4KMD6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_471598</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542979.1">
        <property type="nucleotide sequence ID" value="XM_009544684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMD6"/>
    <dbReference type="STRING" id="747525.W4KMD6"/>
    <dbReference type="GeneID" id="20677403"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_471598"/>
    <dbReference type="eggNOG" id="ENOG502QWMI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004538_1_0_1"/>
    <dbReference type="InParanoid" id="W4KMD6"/>
    <dbReference type="OrthoDB" id="3429912at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="120"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="669"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="785"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="669"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW86221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="818" mass="88928" checksum="5A0F5F543BD49DF6" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4KN15</accession>
    <name>W4KN15_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_469094</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541161.1">
        <property type="nucleotide sequence ID" value="XM_009542866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KN15"/>
    <dbReference type="FunCoup" id="W4KN15">
        <property type="interactions" value="523"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KN15"/>
    <dbReference type="GeneID" id="20677278"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_469094"/>
    <dbReference type="eggNOG" id="KOG1678">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080796_0_0_1"/>
    <dbReference type="InParanoid" id="W4KN15"/>
    <dbReference type="OrthoDB" id="10255148at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW87233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="201" mass="23884" checksum="D3D943420D1F8D33" modified="2014-03-19" version="1">MGAYKYIGELYKKKQSDVLRFLLRVRCWEYRQLNVIHRASRPSRPDKARRLGYKAKQGYVIYRVRVRRGNRKKHVPKGATYGKPVHQGVNHLKFQRGLRSTAEERVGKRCANLRVLNSYWINQDGVYKYYEVILVDPNHKAIRRDPKINWITAPVHKRREARGLTSIGKQNRGLGKGHRYNHTPRVATWKKHNTLSLRRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNU1</accession>
    <name>W4KNU1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_447981</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541372.1">
        <property type="nucleotide sequence ID" value="XM_009543077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNU1"/>
    <dbReference type="STRING" id="747525.W4KNU1"/>
    <dbReference type="GeneID" id="20675813"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_447981"/>
    <dbReference type="eggNOG" id="ENOG502S5CU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081023_0_0_1"/>
    <dbReference type="InParanoid" id="W4KNU1"/>
    <dbReference type="OrthoDB" id="8949486at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22887">
        <property type="entry name" value="Atg16_CCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045160">
        <property type="entry name" value="ATG16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013923">
        <property type="entry name" value="Autophagy-rel_prot_16_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878">
        <property type="entry name" value="AUTOPHAGY PROTEIN 16-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19878:SF8">
        <property type="entry name" value="AUTOPHAGY-RELATED 16, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08614">
        <property type="entry name" value="ATG16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 16" evidence="4">
        <location>
            <begin position="11"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="224"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="129"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW87477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="281" mass="31417" checksum="E9C4131BD617B1D4" modified="2014-03-19" version="1">MAEPAWQELLRLRLAERNAKETAFAPIIEQYRRLAQQTKLLKERNASLLRAVASVKQNPSSSTVFVPGSGEENPVSAAYISSLESQISSLRDELATVYKTQGQNAQRLLAMNETLREKEELSRLDSEALRKSRDEIANLRRKVDQHAEVMAEKDRTAQILHDEISTLQLELGQIEDRNQNLTRDNAKLLQRWLDAKQAEVNKMNEANEFYQDMRTRHEAVLNWRDGSEATSNAGENVDTRSVSRRSSVSGNGSANGEGRGAAGKDGMRSQPEKGVSLTPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNW1</accession>
    <name>W4KNW1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_306549</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541420.1">
        <property type="nucleotide sequence ID" value="XM_009543125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNW1"/>
    <dbReference type="GeneID" id="20669416"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_306549"/>
    <dbReference type="eggNOG" id="KOG1911">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012918_0_0_1"/>
    <dbReference type="InParanoid" id="W4KNW1"/>
    <dbReference type="OrthoDB" id="433924at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18968">
        <property type="entry name" value="chromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="385"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW87528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1011" mass="113624" checksum="5EB02367EFA22A0A" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KP08</accession>
    <name>W4KP08_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_167147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </evidence>
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</entry>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
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                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
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                <person name="Stenlid J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="636" mass="68626" checksum="7B4AD81B61516564" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="8">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="9" type="ORF">HETIRDRAFT_42313</name>
    </gene>
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            <taxon>Agaricomycetes</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
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                <person name="Bouzid O."/>
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                <person name="Cullen D."/>
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                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
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                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Solheim H."/>
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                <person name="de Vries R.P."/>
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                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
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        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
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    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="PRK05399.1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF34">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
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    </dbReference>
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        <property type="entry name" value="MutS_I"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNA_mis_repair_Msh6"/>
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    </dbReference>
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        <property type="entry name" value="MUTSac"/>
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    </dbReference>
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        <property type="entry name" value="MUTSd"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="8">
        <location>
            <begin position="798"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW87470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="941" mass="103862" checksum="E985A5418201EBCB" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMQ7</accession>
    <name>W4JMQ7_HETIT</name>
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        <recommendedName>
            <fullName evidence="11">Iron-sulfur cluster biogenesis chaperone, mitochondrial</fullName>
            <ecNumber evidence="3">3.6.4.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_442732</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. Assisted by the DnaJ-like co-chaperone jac1 and the nucleotide exchange factor mge1, it mediates ATP-dependent Fe-S cluster transfer from the scaffold proteins isu1/isu2 to grx5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="3"/>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553307.1">
        <property type="nucleotide sequence ID" value="XM_009555012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JMQ7"/>
    <dbReference type="FunCoup" id="W4JMQ7">
        <property type="interactions" value="618"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JMQ7"/>
    <dbReference type="GeneID" id="20675482"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_442732"/>
    <dbReference type="eggNOG" id="KOG0102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_2_1_1"/>
    <dbReference type="InParanoid" id="W4JMQ7"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000005">
        <property type="entry name" value="Heat shock protein ssb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000007">
        <property type="entry name" value="Heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003520">
        <property type="entry name" value="PRK05183.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="647"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="649"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00059314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW74832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="666" mass="72133" checksum="0B432236E54EA238" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JN13</accession>
    <name>W4JN13_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_108372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553410.1">
        <property type="nucleotide sequence ID" value="XM_009555115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JN13"/>
    <dbReference type="STRING" id="747525.W4JN13"/>
    <dbReference type="GeneID" id="20666342"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_108372"/>
    <dbReference type="eggNOG" id="ENOG502SYFS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1129180_0_0_1"/>
    <dbReference type="InParanoid" id="W4JN13"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW74952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="246" mass="26243" checksum="C7E80C8B1F449D19" modified="2014-03-19" version="1">MSTDPGDRMVYQVRAPTSPTSREPSALQGIAFTDSPTSNLYTQPHPSSSQLSQPVDLNMEVYSPTESRPESPSMPPSPAGTSVHPIFLSTTDSFDQQSDVVTSSLHSIADWLETVDWDAILGRNPLDAATLNSSPLAAAATRVIRYLNAGIVGRSTKVPELQAARPSSAISTQPGPAGTMTYANAVSRSLPAPSSNRTNRSTTRPASRLANTVNDSFVEDIFRLREAHPNLSASELLALQRQAASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPE8</accession>
    <name>W4JPE8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_331072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552768.1">
        <property type="nucleotide sequence ID" value="XM_009554473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPE8"/>
    <dbReference type="GeneID" id="20671632"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_331072"/>
    <dbReference type="HOGENOM" id="CLU_3143268_0_0_1"/>
    <dbReference type="InParanoid" id="W4JPE8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW75339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="49" mass="5244" checksum="AF7A40F374606990" modified="2014-03-19" version="1">MALDCYARSLVTWGVLSACQPWAFARSTGSVLPCMGLGVIVTREADQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPG0</accession>
    <name>W4JPG0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">axe1</name>
        <name evidence="6" type="ORF">HETIRDRAFT_181227</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Esterase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the carbohydrate esterase 1 (CE1) family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552838.1">
        <property type="nucleotide sequence ID" value="XM_009554543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPG0"/>
    <dbReference type="GeneID" id="20668593"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_181227"/>
    <dbReference type="eggNOG" id="ENOG502QTDU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027551_1_1_1"/>
    <dbReference type="InParanoid" id="W4JPG0"/>
    <dbReference type="OrthoDB" id="2425929at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050955">
        <property type="entry name" value="Plant_Biomass_Hydrol_Est"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01840">
        <property type="entry name" value="esterase_phb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037:SF5">
        <property type="entry name" value="FERULOYL ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="1 4" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029039118" description="Carboxylic ester hydrolase" evidence="4">
        <location>
            <begin position="18"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="5">
        <location>
            <begin position="320"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW75418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="356" mass="36464" checksum="814A36021C3D4334" modified="2014-03-19" version="1">MLLTALLTLGTTHLSSTGLVAGAAGALQQVMSFGANPTNVGMFVYKPAQLASPTPLIVAMHFCTGTAQIFFSGTQFANLADTHGFIVVYPNAPDSGGCWDVHTNATLTHDAGGDSLGIASMVRYAIASYGVDPQLVFMTGSSSGAMMTNVLAGAYPDLFQAGVAFSGVPYSCFSGPTLWNSACADGDIIMTPQQWGTLALSGYPGYTGARPRMQLWHGTADTTLFYPNFGEEIKQWTDIFGVSQTPTSMLNNSPAAPWTRTSYGANVMGLSGAGVGHPAPVNEAETLAWFGIAAITPGSGGGGSGSTTSAPTATTTAAGATQTHYGQCGGVGWSGPTACASGFTCKAANDYYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPY7</accession>
    <name>W4JPY7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_39330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552486.1">
        <property type="nucleotide sequence ID" value="XM_009554191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPY7"/>
    <dbReference type="STRING" id="747525.W4JPY7"/>
    <dbReference type="GeneID" id="20672494"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_39330"/>
    <dbReference type="eggNOG" id="ENOG502SNPY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057548_0_0_1"/>
    <dbReference type="InParanoid" id="W4JPY7"/>
    <dbReference type="OrthoDB" id="5568181at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="24471" checksum="FB597982ACAB09B9" modified="2014-03-19" version="1" fragment="single">MSEAPTIPPNPELPFDPTTLPIAQLESLRFKANQIISSIQALAWTIEYGGAHVMPPWPEILSKYTVLLSQTHTFSSALLSVPGSAPVDGPGASQGGLARLALHPRVGLSDTQLDNDFIPLLRNQQTTDVLRLESAAVRRLSEHMETRGALGMSAPTSGPGTSTRPKPEHEDVIRECAEIRDQHDRRADRAIRAVAMLREKYNWRERVAVDEEEPEELDWDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQE7</accession>
    <name>W4JQE7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_455943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552727.1">
        <property type="nucleotide sequence ID" value="XM_009554432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQE7"/>
    <dbReference type="GeneID" id="20676682"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_455943"/>
    <dbReference type="HOGENOM" id="CLU_120096_0_0_1"/>
    <dbReference type="InParanoid" id="W4JQE7"/>
    <dbReference type="OrthoDB" id="2575973at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844015" evidence="2">
        <location>
            <begin position="24"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW75295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="196" mass="19921" checksum="B2A982949AB8BBED" modified="2014-03-19" version="1">MFSFVKLATVAAIALGAITAVCGAPHPADVAEVKRQTSSLTTILADLAAELAPSAAQLSSLNSKNATMETISPIVSRISTSVQNSMTQIKALPAQGNKVTSDEVASGLNNVMQTVLVPAKNVMAIRGVDSAIIIPAFLPLGVILDGLVGAVLITVGELVFVVKATLATLLGGLTAVIFDLGFTTLISTLGLVLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQU1</accession>
    <name>W4JQU1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_119211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552141.1">
        <property type="nucleotide sequence ID" value="XM_009553846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQU1"/>
    <dbReference type="GeneID" id="20666637"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_119211"/>
    <dbReference type="HOGENOM" id="CLU_2292067_0_0_1"/>
    <dbReference type="InParanoid" id="W4JQU1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="101" mass="10428" checksum="DB0F6DA3B3C2DDEF" modified="2014-03-19" version="1">MAEADATRALRYQDASTRARLPVSWLVRLLYADGHEYGASSGAGKGLGIGGAITPDSSALKTASLLKQCTTTAMRKASASVTTTAPKAQVGKSIVANDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQW1</accession>
    <name>W4JQW1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_390389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552187.1">
        <property type="nucleotide sequence ID" value="XM_009553892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQW1"/>
    <dbReference type="GeneID" id="20672451"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_390389"/>
    <dbReference type="HOGENOM" id="CLU_2489361_0_0_1"/>
    <dbReference type="InParanoid" id="W4JQW1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW75952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="87" mass="9393" checksum="8DCD82F0EA9CD8E2" modified="2014-03-19" version="1" fragment="single">AELPLEQVACSFQAKKYLRHKSAGTQEAPNEHSIEIRAPRGRGCVEIAINVPLALPIRFLIASHAAAGSIRVFVVWADLGCAGIRCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4JR75</accession>
    <name>W4JR75_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COP9 signalosome complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_156983</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family. CSN5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552267.1">
        <property type="nucleotide sequence ID" value="XM_009553972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JR75"/>
    <dbReference type="FunCoup" id="W4JR75">
        <property type="interactions" value="715"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JR75"/>
    <dbReference type="MEROPS" id="M67.A01"/>
    <dbReference type="GeneID" id="20667681"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_156983"/>
    <dbReference type="eggNOG" id="KOG1554">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053034_0_2_1"/>
    <dbReference type="InParanoid" id="W4JR75"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000003">
        <property type="entry name" value="COP9 signalosome complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040961">
        <property type="entry name" value="CSN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18323">
        <property type="entry name" value="CSN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="11">
        <location>
            <begin position="53"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW76043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="360" mass="39716" checksum="6096666865009D96" modified="2014-03-19" version="1">MASSNIALKTFSLANDIQEISPQDQIYAFDVEADKQINRDSPWAKDPHYFKSCKISAVALIKMVIHARSGVPHEIMGIMQGKVMGDSLVIVDSFALPVQGTETRVNAASEANEYMVQYVSGSEKAKRLENAIGWYHSHPGYGCWLSGIDVDTQMNNQKFQDPFVAVVIDPNRTISAGRVDIGAFRTYPENYTPPNASASEYQSIPLSKIEDFGVHANQYYPLEVQVFKSSLDTELLALLWNKYWVNTLSQSPLISNRAYAASQLVDLHQKLAKAASNVPHTKPVPPTTKDEILLTTSKRSEKKEDENQLAKNVTDSINIAIEAQHGLIAQVIKDVIFSGRPGQSTAAEVRDAVDSAMMIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRE0</accession>
    <name>W4JRE0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_329766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552327.1">
        <property type="nucleotide sequence ID" value="XM_009554032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRE0"/>
    <dbReference type="GeneID" id="20671520"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_329766"/>
    <dbReference type="HOGENOM" id="CLU_3050589_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRE0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="54" mass="5991" checksum="0500FCE9383BB31F" modified="2014-03-19" version="1">MGIQYSCRGWDGLFNKCGKNLNSLVTLKLSLYHKAFDPSPPEMRAPHHQACASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRX5</accession>
    <name>W4JRX5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_66544</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551898.1">
        <property type="nucleotide sequence ID" value="XM_009553603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRX5"/>
    <dbReference type="GeneID" id="20678785"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_66544"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_918486_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRX5"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF35">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="14"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="241"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW76224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="303" mass="31959" checksum="1D7EB92D73ED6C68" modified="2014-03-19" version="1">MGYSARIAANPYVVGSFACIGGGLFGLDISSMSGVLNNDAYLKAFSSPGPNAQGAIVATMPAGSFVGALAVSALADKFGRKKTVILSGIIWVIGSILQCASINRGMLVVGRIISGISVGLASAVVPVYQSEITAPHIRGRLVAMQQWSITWGILIQYFIQFGCSYINGVASFRIPWGLQMIPAIILSTGMLAFPESPRWLIDHGRFDEALQILADLHGGGDPNNALPPHGVEIRTPLLGHASLRPRGHTPSSPHAHGLPLCAPHSTTHDARRTVHRPPSAARRSPQRATPPSAALARPPARPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRY3</accession>
    <name>W4JRY3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_330082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552097.1">
        <property type="nucleotide sequence ID" value="XM_009553802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRY3"/>
    <dbReference type="STRING" id="747525.W4JRY3"/>
    <dbReference type="GeneID" id="20671546"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_330082"/>
    <dbReference type="eggNOG" id="ENOG502SJRQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059781_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRY3"/>
    <dbReference type="OrthoDB" id="3356102at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004843776" evidence="2">
        <location>
            <begin position="21"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW75855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="389" mass="40069" checksum="293970A9CEE59449" modified="2014-03-19" version="1">MLAPLLTVATLLIGAPAVRASPCVAMDINWNLLAFGLGSKDWNAGTQDQWGSAGKATDITTSGRPPFDGANTSCYLSQFTNAIYVMNGDASNPSNIHLYDATAKSWSTQTVTTGTFDPSSFNAILDHDTNVFYAVSKGELFSLDMALLTSANATALPWNDVQKTPYGDSYQPVMALAQNHIHFIDVPGTPAGDANIFVIHFSYFQPEVQSYPIADGSTFPATHGQASSFFQESGVQQEFAFIPDDGSKTYVINVETNSTQALAGPTTKDAKATYFAGLSSLVQLDSAGAVSYLPYQQGNTAVNSAATWSPVSALSSVVPVTTSASSAAASGTAKASGTASSTGSAKASSSASPSSSNTSTSGSSNGAMSKVFMSGTLGALVVGAVALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSS3</accession>
    <name>W4JSS3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_106554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552149.1">
        <property type="nucleotide sequence ID" value="XM_009553854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSS3"/>
    <dbReference type="GeneID" id="20666172"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_106554"/>
    <dbReference type="HOGENOM" id="CLU_880171_0_0_1"/>
    <dbReference type="InParanoid" id="W4JSS3"/>
    <dbReference type="OrthoDB" id="3266090at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="316" mass="34968" checksum="7F3D9090986E46E1" modified="2014-03-19" version="1">MSSSETPIDYSLEFERDADGNPIGDQFTSFKMTARARACRRQSFIEATKHRTPTAQLPDDGNVSRNKDADILHFGFALSVEQIMRSAEKHDLFMKPRSDDPDLVYISAIPGMRVHLAKTCNAVLFYHMPFTVTGQPCMFALYSNYTMERYQLCEQDEKEVIEILQTELGIVEDPMWYWDRCHNPCSQMLKDDTIGSTLLLALPPYRYCAIACIVHQLGLHSVAALNSQEFRSSSPVSAHEGRELKSAPSSGALACPRGGRGGAFARACAGRARRASGERSGPAGQPVEREPAYTSTGVHRRRSCATRTSHLTPSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JT30</accession>
    <name>W4JT30_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_411938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551501.1">
        <property type="nucleotide sequence ID" value="XM_009553206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JT30"/>
    <dbReference type="GeneID" id="20672981"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_411938"/>
    <dbReference type="HOGENOM" id="CLU_1503634_0_0_1"/>
    <dbReference type="InParanoid" id="W4JT30"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="179" mass="19026" checksum="998DA70120CB069A" modified="2014-03-19" version="1">MEKRSEGNEDPPESSDAPSSKGSIFKDRNPRRRGARTTTTESPVRTRTRYQTRIETAQPAAVQPSASVPSAPASFLTPASPSPPAPDFPGEPSTTSFTPPLFYPSSPSTDGHVDEATTSADDALGSSSKPIKARTPSGKAKAKETEKAKAKAKGKEKGKGKGTEKEKRMEKGKGKERAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTC8</accession>
    <name>W4JTC8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_412008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551645.1">
        <property type="nucleotide sequence ID" value="XM_009553350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTC8"/>
    <dbReference type="GeneID" id="20672988"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_412008"/>
    <dbReference type="HOGENOM" id="CLU_1622907_0_0_1"/>
    <dbReference type="InParanoid" id="W4JTC8"/>
    <dbReference type="OrthoDB" id="2858653at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="18519" checksum="2342613AAB619910" modified="2014-03-19" version="1" fragment="single">MNSLPYELLNAIVHEVPPGQNLLQVRMLNRTFCAITTPLIFRRVDVTNTPESARTFSNILRSKALACVVQEIVFRENYAVLMGKGLYLFQGSRQALSRLSLNTSHPEVIALQESLALSFSCLRDFSSIKCLSLSFWSGSRHFYSQHPWNLQMAIIRAISGQLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTQ9</accession>
    <name>W4JTQ9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MutL C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_442135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551696.1">
        <property type="nucleotide sequence ID" value="XM_009553401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTQ9"/>
    <dbReference type="STRING" id="747525.W4JTQ9"/>
    <dbReference type="GeneID" id="20675416"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_442135"/>
    <dbReference type="eggNOG" id="KOG1978">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045861_1_0_1"/>
    <dbReference type="InParanoid" id="W4JTQ9"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.100:FF:000001">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="1">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="189" mass="21784" checksum="E37F32CD7FDAC04F" modified="2014-03-19" version="1">MDDLFIVDQHAADEKYNFETLQQTTRIESQRLFKPRQLEITAADKLVATENLDVLKQNGFELDPGEENDSGEKREVKLVAQPFSKSTVFDMKDLEELLHLMRDLPPGTMVRCSKARAMFAMRACRKSIMVGKALDAKQMTAVVRHMGTMEQPWNCPHGRPTMRHLSDLMAFGRWDAARKTDWAVYRPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTW2</accession>
    <name>W4JTW2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_328932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551753.1">
        <property type="nucleotide sequence ID" value="XM_009553458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTW2"/>
    <dbReference type="GeneID" id="20671457"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_328932"/>
    <dbReference type="HOGENOM" id="CLU_050560_0_0_1"/>
    <dbReference type="InParanoid" id="W4JTW2"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="479" mass="52700" checksum="84A3854A3E3202AA" modified="2014-03-19" version="1">MLLHDDHDASSPSRNSSPDVVLMVANPDVERVERGTSPHRPDAGRIDRGTSPQQPGSTGVLLTPHTNNFSDDDTEDYAKFKERERTRRPSPERASRGAPRHESSDDRNQSSLGPLPVGVPPPSEGTRPSGVAGPSGFRARTAAQLPGHGEAEPIPVLSETAPPPVPTSEPIPSSMGGPPPRTDPHAGELERHADALLQRNTISAVIQMATAMALQRLANFSAGQPGNEHSDVPRRLASASLQIRALALQTDPDTASWYAHNDGRPRALLIHPDEFSQYVNRELLPALLFGGELGNVQPSRTDPFRVVTWNVPRPGEHPTPAPNPRRVPRTVVERPPPRQREVPTAYNHTATPPSHRIRGLPLSQGNTDEEEPPVYRRNEGRRSRGNQATLGRGTTAGRSVRHRPRSPPPSARLRTNEREDNRSSRRTRRIDSEARRNSSWTRSELDAWDALDDPGNYDEADPYYRPDEGGGDYQGPFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUI2</accession>
    <name>W4JUI2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_327427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550751.1">
        <property type="nucleotide sequence ID" value="XM_009552456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUI2"/>
    <dbReference type="GeneID" id="20671330"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_327427"/>
    <dbReference type="HOGENOM" id="CLU_094659_1_0_1"/>
    <dbReference type="InParanoid" id="W4JUI2"/>
    <dbReference type="OrthoDB" id="10255174at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW77213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="149" mass="16564" checksum="B1CDCFC2C76C381E" modified="2014-03-19" version="1" fragment="single">TRMFALVIGIDKYKSPKVDDLGGCVHDAKSFAALLSERFNVPDSQLSILTDESATREAIISHFLTDLVQNPNIERDDTIIFYYAGRGSRAEASQLLSSQENAMETLCPHDEWLEDDHGLIPGIPGRTMNALFRELARAKGDNIVRISDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUL8</accession>
    <name>W4JUL8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_480729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551469.1">
        <property type="nucleotide sequence ID" value="XM_009553174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUL8"/>
    <dbReference type="GeneID" id="20677930"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_480729"/>
    <dbReference type="HOGENOM" id="CLU_2360002_0_0_1"/>
    <dbReference type="InParanoid" id="W4JUL8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="96" mass="10395" checksum="83CE272F707D6128" modified="2014-03-19" version="1">MLDATPADPHVRCVVRRAPLLLGCPAHAVSRAACGAPAFRIHYTRPAWDDVRMVRHVDPHGTWRLTIHCRGTALIGALPGRADACSIQYMRGSSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4JV62</accession>
    <name>W4JV62_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_326548</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550876.1">
        <property type="nucleotide sequence ID" value="XM_009552581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JV62"/>
    <dbReference type="STRING" id="747525.W4JV62"/>
    <dbReference type="GeneID" id="20671251"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_326548"/>
    <dbReference type="eggNOG" id="ENOG502QRET">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035914_1_3_1"/>
    <dbReference type="InParanoid" id="W4JV62"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004843899" description="Tyrosinase copper-binding domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW77359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="362" mass="40894" checksum="E4165AC49AB698C6" modified="2014-03-19" version="1">MGALRISFFIFLATAFCTVRAICTHPSVRKEWRQMTVTERSNWVSAVNCLSHHPHDPRLMPTVNISISAIPPVNTTGSYYDDFVYMHMDLNVLIHFTGLFLPWHRWYVAVYETALKERCGYEGSSPYWNWSMDSGNFFSSAFFEDTDPKSGLGGWGDPTNDYQVPDGGFSDFRISYPAPHTLRRNFTLQPYLGAPASMSPFFIDPGKYANTSFTPEEVSKLVNGFVGDFKSFQAYFEAFEGAHGSVHEIMGGDLAGMCPKNAPANCTPGPTWSANEPLFWMHHAMVDKVWYDWQHKNPSNFWSYSGGSVEAITNVTYYNEYPNGAPPYLNFQSLMPADGLFPQATIHDVFNTTDGILCYVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4JV70</accession>
    <name>W4JV70_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Plus3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_37203</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550468.1">
        <property type="nucleotide sequence ID" value="XM_009552173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JV70"/>
    <dbReference type="FunCoup" id="W4JV70">
        <property type="interactions" value="690"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JV70"/>
    <dbReference type="GeneID" id="20671846"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_37203"/>
    <dbReference type="eggNOG" id="KOG2402">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036626_0_0_1"/>
    <dbReference type="InParanoid" id="W4JV70"/>
    <dbReference type="OrthoDB" id="166375at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115:SF8">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00719">
        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51360">
        <property type="entry name" value="PLUS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Plus3" evidence="6">
        <location>
            <begin position="207"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="126"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="447"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="133"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW77432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="540" mass="61436" checksum="92B04E826E3F7B98" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVA4</accession>
    <name>W4JVA4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_246942</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550567.1">
        <property type="nucleotide sequence ID" value="XM_009552272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JVA4"/>
    <dbReference type="GeneID" id="20669135"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_246942"/>
    <dbReference type="HOGENOM" id="CLU_101063_0_0_1"/>
    <dbReference type="InParanoid" id="W4JVA4"/>
    <dbReference type="OrthoDB" id="3260945at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030894">
        <property type="term" value="C:replisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW77010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="213" mass="23964" checksum="9D40F27726E9A07F" modified="2014-03-19" version="1" fragment="single">GKTAVAYLHLILISHLSKKPPRSLLLFVRSIQSTAVVLMITSLIDVGLCQVEEMSRMGVRAVSLDKETVREAHQKGKNLLKKVKQGKWSVIIMSPERLNSPEFERIVQNEWFRKLLALYVINEAHVVLAWAADFCEAYGQINHVIARIPVGILVLAMSRTLGSEAKTSLTKFLGFYDGTYQTIQRSCEQPNLRIIFSTLMHGLGGKDFPDIAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W4JW41</accession>
    <name>W4JW41_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_125523</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550811.1">
        <property type="nucleotide sequence ID" value="XM_009552516.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="W4JW41">
        <property type="interactions" value="339"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JW41"/>
    <dbReference type="GeneID" id="20666908"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_125523"/>
    <dbReference type="eggNOG" id="KOG1240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001696_0_1_1"/>
    <dbReference type="InParanoid" id="W4JW41"/>
    <dbReference type="OrthoDB" id="242910at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13980">
        <property type="entry name" value="STKc_Vps15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000497">
        <property type="entry name" value="Phosphoinositide 3-kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="28"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="1141"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="1495"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="206"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="552"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="886"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="946"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1014"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="552"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="946"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1038"/>
            <end position="1050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW77285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1604" mass="176315" checksum="AF125462E3AD0831" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWC6</accession>
    <name>W4JWC6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_441426</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 14">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549882.1">
        <property type="nucleotide sequence ID" value="XM_009551587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWC6"/>
    <dbReference type="FunCoup" id="W4JWC6">
        <property type="interactions" value="411"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JWC6"/>
    <dbReference type="GeneID" id="20675362"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_441426"/>
    <dbReference type="eggNOG" id="KOG0374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_0_0_1"/>
    <dbReference type="InParanoid" id="W4JWC6"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000007">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="11">
        <location>
            <begin position="122"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW77863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="331" mass="38061" checksum="30403DA9CB27869A" modified="2014-03-19" version="1">MADNATEIDLDSVIDRLLEVRGNRPGKPVQLQEYEIKYLCTKAREIFINQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFTMHGGLSPDLQSMEQIRRVMRPTDVPDTGLLCDLLWSDPDKDITGWSENDRGVSFTFGPDVVSRFLQKHDMDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLLCSFQILKPAEKKAKYPYGGMNMGRPVTPPRKQKKKDGKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWS4</accession>
    <name>W4JWS4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_429587</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
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                <person name="Velez H."/>
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                <person name="Yakovlev I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Lunden K."/>
                <person name="Morin E."/>
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                <person name="Park J."/>
                <person name="Raffaello T."/>
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                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550051.1">
        <property type="nucleotide sequence ID" value="XM_009551756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWW2"/>
    <dbReference type="GeneID" id="20666266"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_107663"/>
    <dbReference type="HOGENOM" id="CLU_2306508_0_0_1"/>
    <dbReference type="InParanoid" id="W4JWW2"/>
    <dbReference type="OrthoDB" id="8943665at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="100" mass="11499" checksum="C3F686AA179C4DC4" modified="2014-03-19" version="1">MGRSARTVHDDMCGSLASVAELHQSSLQPDHSYSQPDHSSFQPDYPSFQLDYPSFQLDYPSFQLDYSAFQLDYSTFQLDYPSFQLDYSSSQPDLVRLRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWY5</accession>
    <name>W4JWY5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_411603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550894.1">
        <property type="nucleotide sequence ID" value="XM_009552599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWY5"/>
    <dbReference type="GeneID" id="20672961"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_411603"/>
    <dbReference type="HOGENOM" id="CLU_2306512_0_0_1"/>
    <dbReference type="InParanoid" id="W4JWY5"/>
    <dbReference type="OrthoDB" id="10609979at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="100" mass="10761" checksum="5869BEC4EAEC2132" modified="2014-03-19" version="1">MPYPSSYQNVAEHRAANSGAAANPGASAEPAERMRWSVPHTEVVFARPRTPVARDRTKDRVLRQSGDLSLTEAWTAFMSQMDVPGVGAAPSAGRPGREGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4JY45</accession>
    <name>W4JY45_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleosome assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_479626</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550434.1">
        <property type="nucleotide sequence ID" value="XM_009552139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JY45"/>
    <dbReference type="FunCoup" id="W4JY45">
        <property type="interactions" value="261"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JY45"/>
    <dbReference type="GeneID" id="20677879"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_479626"/>
    <dbReference type="eggNOG" id="KOG1507">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038841_1_0_1"/>
    <dbReference type="InParanoid" id="W4JY45"/>
    <dbReference type="OrthoDB" id="27325at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.90:FF:000003">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="358"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="358"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW78468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="47001" checksum="82508A244CA47831" modified="2014-03-19" version="1">MSSTVPISQNDLTAPTPQNTPLTHAPITAGLSRPTVPDISEDNEPAEDASPAHHAMLGLVHGKIAGLLGKSSGYIESLPDNVKLSVEALKGVQVKQNELQNQYKRECFELEKKYLDLQKPLYDRRHALISGTAQPTPEELEAGAAQSLKDDPDHKPLDSSSAAAAAAIPEFWLTALRNHVGLAELITERDAAALKHLTDIRIEYLPPTEPKPGFKLLFSFGPNDYFENSLLEKTYVYQEEVGYSGDFVYDRAIGTEIKWKEDQDLTKEFEIKKQRNKNTNRTRLVRKARPTESFFNFFSPPVPPNEDAIDNGDIEEEELDELEEKLEMDYQIGEDIKEKIIPRAIDYFTGKALEYDMLDEDDDDDYEDLDDDEDDEDRFEDDDSDSEEELPARRRGGPKGRGGAPASAASVNPEECKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYT0</accession>
    <name>W4JYT0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_119985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550031.1">
        <property type="nucleotide sequence ID" value="XM_009551736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYT0"/>
    <dbReference type="GeneID" id="20666672"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_119985"/>
    <dbReference type="HOGENOM" id="CLU_733744_0_0_1"/>
    <dbReference type="InParanoid" id="W4JYT0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="377" mass="40009" checksum="EDDD081B5A262CBA" modified="2014-03-19" version="1">MDVQSHGPHLPDMVVPLRPDAGAPVRSFHLSSSSHKLPRGDLLRADRRTARCLLDSQRAGQGADATRRAPDCPTPGLARSSLTSVAFADSDALALASGGRVQAGMEREWGRWRALGGSGSRGIGEAEVVPWGLSAAGVVDERVACMGWAGGWTSAAFQALHLGTGLRLSFERSCVSGCGFWRSGAVVGAVASGFLTRQVGGGARPRLPRHWAGTAELLSGLVSSRASACPVKSDSEPRRHLAPCRPTRAYLICPSHLSINIVRGGGDAGPDIYKYCHLQGDAWQYLPATVDCSPSMQSAAVRGDDTDGRSARACAASSYHDWSLENIKYVKSEEISVERACILQQSMGQSPVLVNEVHVYPPRSACLGWWGDAQVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYT7</accession>
    <name>W4JYT7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Afadin and alpha-actinin-binding-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_445705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADIP family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549028.1">
        <property type="nucleotide sequence ID" value="XM_009550733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYT7"/>
    <dbReference type="STRING" id="747525.W4JYT7"/>
    <dbReference type="GeneID" id="20675640"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_445705"/>
    <dbReference type="eggNOG" id="ENOG502QQJF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016779_0_0_1"/>
    <dbReference type="InParanoid" id="W4JYT7"/>
    <dbReference type="OrthoDB" id="312015at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021622">
        <property type="entry name" value="Afadin/alpha-actinin-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47057">
        <property type="entry name" value="AFADIN/ALPHA-ACTININ-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47057:SF1">
        <property type="entry name" value="AFADIN_ALPHA-ACTININ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11559">
        <property type="entry name" value="ADIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="408"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="566"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="687"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="221"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="321"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="459"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="572"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="700"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="723"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="766"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW78713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="835" mass="90095" checksum="3F1DA02DC09D4DF5" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYU6</accession>
    <name>W4JYU6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_428575</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
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        <property type="protein sequence ID" value="ETW78723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="W4JYU6">
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    <dbReference type="GeneID" id="20674282"/>
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    <dbReference type="eggNOG" id="KOG0990">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000004">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000129">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF9">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="65"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW78723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="352" mass="39529" checksum="CC72DF7D9956F0DC" modified="2014-03-19" version="1">MDIDQETQPAQLALSSLAKGKGKAVDRQEDENLPWVEKYRPVTLDDVVSHKDITSTIEKFIEKNRLPHLLFYGPPGTGKTSTILAVARRIYGPGFRKQILELNASDDRGIDVVREQIKQFAETRTLFAKGYKLIILDEADMMTTAAQAALRRVIEQYTKNVRFCIICNYVNKIIPAIQSRCTRFRFSPLPIPEVEKRVDHVVQSEQVNLTEDGKKALLKLSKGDMRRALNVLQACHAAYDLTSEMEVYTCTGNPHPSDIETVVHSMMADEFTTSYQMISALKTERGLALQDLLVGAYEYIETIELPPAARVYLLDHLATTEHRLAGGASEKMQLTALLGAFKNAVELTQKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYZ6</accession>
    <name>W4JYZ6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_453302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549015.1">
        <property type="nucleotide sequence ID" value="XM_009550720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYZ6"/>
    <dbReference type="GeneID" id="20676365"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_453302"/>
    <dbReference type="HOGENOM" id="CLU_1142713_0_0_1"/>
    <dbReference type="InParanoid" id="W4JYZ6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="243" mass="26643" checksum="4CC682BF309BAAE6" modified="2014-03-19" version="1">MAGRRDDPSLSRHASAPSRARSLHLQAFQFCKHSTYLFANDCHHTLRSVVHFSARFELKASAACDYGNRSPFMSCATGLRPSATHLRPSIRHSILAHSTPAGARLPRIETQEGELVIHQGSPFSPSAAATLRSWFVRCPLLPVSRSSYGWQATLCNRERKPASRQQAPHFPPAAAATPRPPFVRSRLRWPEAASHAPQLSHEGEPGFHLGDELCATPRPSKPSLAADRPAPKALVDFGFGFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZ08</accession>
    <name>W4JZ08_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">MFS sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_157457</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550120.1">
        <property type="nucleotide sequence ID" value="XM_009551825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZ08"/>
    <dbReference type="GeneID" id="20667726"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_157457"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_43_5_1"/>
    <dbReference type="InParanoid" id="W4JZ08"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000100">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF4">
        <property type="entry name" value="SYMPORT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="106"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="598"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="601"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW78121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="629" mass="69884" checksum="9A3F634C81DE5C0E" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZE3</accession>
    <name>W4JZE3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_410812</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549232.1">
        <property type="nucleotide sequence ID" value="XM_009550937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZE3"/>
    <dbReference type="FunCoup" id="W4JZE3">
        <property type="interactions" value="420"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JZE3"/>
    <dbReference type="GeneID" id="20672901"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_410812"/>
    <dbReference type="eggNOG" id="KOG3168">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_1_1_1"/>
    <dbReference type="InParanoid" id="W4JZE3"/>
    <dbReference type="OrthoDB" id="2020720at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
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        <property type="term" value="C:U5 snRNP"/>
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        <property type="term" value="F:RNA binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Sm_B"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Small nuclear ribonucleoprotein SmB, putative"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LSM_dom_sf"/>
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        <property type="entry name" value="Sm"/>
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        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="11">
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            <begin position="88"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
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            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
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            <begin position="123"/>
            <end position="176"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00041355"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW78948.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="176" mass="18843" checksum="5CE05E77368BD539" modified="2014-03-19" version="1">MPPPKSKGGKMLSLINWRLKVTITDGRALTGQMLAFDRHMNLVLAECEEFRRIRPKKKPGETEAGPEQEVKRTLGLVILRGEAVVSLTVEGPPPVQDEDKKNALPVGPGRGMPAGRGMGMMPPMGPPSLQRPPMPFAPPGMPGAPPGFRPPGFPQNLPFPPPGFGGPPPGFQQPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZN5</accession>
    <name>W4JZN5_HETIT</name>
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        <recommendedName>
            <fullName evidence="10">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_435526</name>
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    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">TC 32-1</strain>
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    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:endosome organization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Znf_ZZ"/>
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        <property type="entry name" value="SEQUESTOSOME 1-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SEQUESTOSOME-1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZnF_ZZ"/>
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    </dbReference>
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        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PB1" evidence="7">
        <location>
            <begin position="12"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="700"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="820"/>
            <end position="877"/>
        </location>
    </feature>
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        <location>
            <begin position="144"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="507"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="567"/>
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    </feature>
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        <location>
            <begin position="171"/>
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        </location>
    </feature>
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        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="514"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="574"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="594"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW79012.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="996" mass="109345" checksum="ADC66F566C967AF7" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0A0</accession>
    <name>W4K0A0_HETIT</name>
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        <recommendedName>
            <fullName evidence="7">Ribosomal protein L35Ae</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_441224</name>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549414.1">
        <property type="nucleotide sequence ID" value="XM_009551119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0A0"/>
    <dbReference type="FunCoup" id="W4K0A0">
        <property type="interactions" value="299"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K0A0"/>
    <dbReference type="GeneID" id="20675339"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_441224"/>
    <dbReference type="eggNOG" id="KOG0887">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100745_2_0_1"/>
    <dbReference type="InParanoid" id="W4K0A0"/>
    <dbReference type="OrthoDB" id="1166329at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.190:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
        <property type="entry name" value="Ribosomal_eL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW79154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11972" checksum="A57A476C623F8901" modified="2014-03-19" version="1">MASTRLYSKGRVLGHKRGKRNTRPNTSLLQIEGVANKEDAQFYLGKRVAYVYRAKREIQGSKVRVIWGRVTRSHGNSGVVKSKFRSNLPPHAFGASVRIMLYPSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0W7</accession>
    <name>W4K0W7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_28187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547903.1">
        <property type="nucleotide sequence ID" value="XM_009549608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0W7"/>
    <dbReference type="STRING" id="747525.W4K0W7"/>
    <dbReference type="GeneID" id="20669278"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_28187"/>
    <dbReference type="HOGENOM" id="CLU_164205_0_0_1"/>
    <dbReference type="InParanoid" id="W4K0W7"/>
    <dbReference type="OrthoDB" id="3265515at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW79473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="99" mass="11325" checksum="3B791CD180FF9A69" modified="2014-03-19" version="1" fragment="single">GRGRLTLRWVPGHVDIVGNERSDEEAKAAARGLTSMDTVLPKAIRGQLPFSRSAARQRFNDGLKKRWKKLMEQSPRWQKLQRIDPTAPSNRFRKITSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0Z5</accession>
    <name>W4K0Z5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_419214</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548086.1">
        <property type="nucleotide sequence ID" value="XM_009549791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0Z5"/>
    <dbReference type="GeneID" id="20673543"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_419214"/>
    <dbReference type="eggNOG" id="ENOG502SQ8R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045560_0_0_1"/>
    <dbReference type="InParanoid" id="W4K0Z5"/>
    <dbReference type="OrthoDB" id="3133596at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="2">
        <location>
            <begin position="42"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW79503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="397" mass="45323" checksum="BCA7019DD4F17885" modified="2014-03-19" version="1">MTASPSLNIESNSSSSNSPNKKRRRARSSNPVPAEPEATEKCLVTGDSVTESPIHLCHVFPELHWSNHPLLSRLEWAWGMKYDTIQMDTDSNTIPLRHDWRKLFESGRWALMPSMDMIDKLWDRWIKFPLSQGNVPSIEDMYNGAETFEYRLVPLFPDVPPISPRNKVEDVPKGKCDEDAGASTYSYPFDTLPPIFARVKPHFVIYDTGQKLEATFSEWTETTSIMACIYGVTYKKAEFANTVVYQTYCTWDRPAHPATFVTSPRRIDSRPRSGLITPGQLSSANQRASRPPKRFRISDDIDSVCLQPNVVRYATSLSRVSPCGSDVLIVGDSGWDTEVDPEFEKIHLRRVIKAVKRWVRECHREALSSGGWVSCFTHDEQVKRYRQEPARKMISTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4K124</accession>
    <name>W4K124_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450 monooxygenase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cyp1</name>
        <name evidence="9" type="ORF">HETIRDRAFT_103815</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548119.1">
        <property type="nucleotide sequence ID" value="XM_009549824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K124"/>
    <dbReference type="STRING" id="747525.W4K124"/>
    <dbReference type="GeneID" id="20665937"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_103815"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_10_1"/>
    <dbReference type="InParanoid" id="W4K124"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW79538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="449" mass="49203" checksum="4C378BEB4028C83C" modified="2014-03-19" version="1">MFPTAVIVLSAIIAHVVFNRLEPRGAAVIGILILGIPATLSIALRASFTSLLSSAAFTLSNYLLSLISSLCIYRLSPFHPLARFPGPVLFKLSRIPAWILARSGVQHHYYLALHQRFGPYVRTGPNHLHVSDASAIPVVLGSRAFTKGGRYSAIKRPGSQGSLLSMSDPHEHSQRRRIWDRALNATALKDYQDSLANRVAQLVTGLEQRVQDGPLDLSEWISMFSFDFMGDLAYGSGFNLLEQGEDVQDLIRIVSAGVRQQELAGAIPWIKPFYDMLPTSSNDLRFVQFAKEMVLKRKAQETPMDEDGSGTPPLVFPTLVQESSLALVAGSDTSGTCLANIFYYLLSNVAAYRTLQSEIDKAEMDSTNATLAGLPYLNAVINETLRLQSVVPNGVQRVLSSKSEGVIISGNYIPPSTTVQVSTYIVHRDPGNFSRIRTLSCPNAGWRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1B2</accession>
    <name>W4K1B2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6589 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_322362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548092.1">
        <property type="nucleotide sequence ID" value="XM_009549797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1B2"/>
    <dbReference type="STRING" id="747525.W4K1B2"/>
    <dbReference type="GeneID" id="20670844"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_322362"/>
    <dbReference type="eggNOG" id="ENOG502S7C8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1396493_0_0_1"/>
    <dbReference type="InParanoid" id="W4K1B2"/>
    <dbReference type="OrthoDB" id="2496395at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6589" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="195" mass="22038" checksum="607BD0D302A83D62" modified="2014-03-19" version="1">MAASHRFITTHLGQPNHLLTNPTSLVTHNMILECKPIVATSLPPFQTCQDLIFIFFYAQVLHYILLVAELTSLDKYMDSLTWETLQSHAATVVNRFTDNCTVHHLQQEHAVHSSHRGNMVFENAILFLRDALHLREFLDAIKAGDSGHVLNILKITHVWPASLIKVVLNNWLVNPTGSLKVGMRWTYCKSTLTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1B8</accession>
    <name>W4K1B8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADPH-dependent diflavin oxidoreductase 1</fullName>
            <ecNumber evidence="9">1.18.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">NADPH-dependent FMN and FAD-containing oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TAH18</name>
        <name evidence="12" type="ORF">HETIRDRAFT_419295</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H(2)O(2)-induced cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 oxidized [2Fe-2S]-[protein] + NADPH = 2 reduced [2Fe-2S]-[protein] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67716"/>
            <dbReference type="Rhea" id="RHEA-COMP:17327"/>
            <dbReference type="Rhea" id="RHEA-COMP:17328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with DRE2; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="9">Relocalizes to mitochondria after H(2)O(2) exposure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548176.1">
        <property type="nucleotide sequence ID" value="XM_009549881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1B8"/>
    <dbReference type="FunCoup" id="W4K1B8">
        <property type="interactions" value="456"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K1B8"/>
    <dbReference type="GeneID" id="20673558"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_419295"/>
    <dbReference type="eggNOG" id="KOG1159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_17_6_1"/>
    <dbReference type="InParanoid" id="W4K1B8"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="22"/>
            <end position="166"/>
        </location>
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            <begin position="213"/>
            <end position="449"/>
        </location>
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        <location>
            <begin position="28"/>
            <end position="33"/>
        </location>
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        </ligand>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW79607.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="602" mass="67636" checksum="6DEE863431B35C97" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1C0</accession>
    <name>W4K1C0_HETIT</name>
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        <recommendedName>
            <fullName evidence="1">DUF6589 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">HETIRDRAFT_428657</name>
    </gene>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="30"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="295" mass="33861" checksum="A4360ACC86EE9374" modified="2014-03-19" version="1">MARAIDSLTLSDLGKVDFYTNMQMLEFTHFQELSSRNILPSLQNLLCYAKVLATQYSTNIAYKQALRLRSALNSSEGGWDIPIESSQASLEDAINGNVFQGDWTLANSVLLLRDGIWSLEVCQAIATGDIGHVWEVFKVWIFTFVGAGNHNYMQYLLEIHCNIKFKYSEATRITLFNNWLVNLKGEPGHFHKLELMQEHFNFWLEELTQHKGKEFGDEWYRHMLAMHIYHFLRLKEEMKSSIPLVRQNKGHTHMDIHNKVPKSCAYAVKGSCIISKAGETLDSTLWTVLLLVTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4K227</accession>
    <name>W4K227_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase II degradation factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HETIRDRAFT_459750</name>
    </gene>
    <organism evidence="18 19">
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
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                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
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                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEF1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="ETW79868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_459750"/>
    <dbReference type="eggNOG" id="ENOG502S359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006015_0_0_1"/>
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                <person name="Yakovlev I."/>
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        <source>
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    </evidence>
    <sequence length="549" mass="59608" checksum="9414035268E4456D" modified="2014-03-19" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="van Diepen L.T."/>
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                <person name="Hansson D."/>
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                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
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                <person name="Karlsson M."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Lunden K."/>
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                <person name="Yakovlev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">TC 32-1</strain>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <source>
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        <source>
            <dbReference type="EMBL" id="ETW79993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
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</entry>
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        </lineage>
    </organism>
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                <person name="Asiegbu F."/>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
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                <person name="Lucas S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">TC 32-1</strain>
        </source>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW80022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="44532" checksum="03804D40F0A21A17" modified="2014-03-19" version="1">MAVTLDADCMPLSDYVVEHIDHVRHLELRDGPMGDVTTVLTRLNRPAPMLESVNIFCDVRGTLQTFLHTPPRACATLFSLKFINHLFTYAETDLPPKQYTYGEVPDVLERMPALEVLYVHRVLSLGPASMGTSRSISFPRLNELSLGSVLNSCCSLVANLALPAHTSVHMICHPFSHTWEDCQLLVPFMAKRVAAAAAIHVVEHLAIYSLSDMDITLTIGPLEARRAPSSALPFNVVITFSLSGGAIIRRLVEAFCAVLPLGGLRELSVFTGLESWWRPQHWQEMLRPVQCVETVNVRGTAAMHLVSSLAWESCAGEPAEEAPSLLFPALETLAMWGLTIHDDTSETLCSDYELVGALVHRTHKAPLETLRFLRYNVQKKWIEKIEAIVPTVTLDFDAQFP</sequence>
</entry>
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    <accession>W4K2S2</accession>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
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                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
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                <person name="Karlsson M."/>
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                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
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                <person name="Murat C."/>
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                <person name="Raffaello T."/>
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                <person name="Velez H."/>
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                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79650.1"/>
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        <property type="nucleotide sequence ID" value="XM_009549920.1"/>
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    <dbReference type="AlphaFoldDB" id="W4K2S2"/>
    <dbReference type="STRING" id="747525.W4K2S2"/>
    <dbReference type="GeneID" id="20675301"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_440732"/>
    <dbReference type="eggNOG" id="ENOG502SCFZ">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053871_0_0_1"/>
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    <dbReference type="OrthoDB" id="2536866at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="301" mass="33430" checksum="9F9E8B2EF0B62D64" modified="2014-03-19" version="1">MVIVNEKSMLPPPPPYLSRSLDAHPPPFPGSSTRPKPSFSTLPPHILLVILYHAFPQTSFLDEGRVERQRRTLYWMSISLRLVSRSVYIACMHILRSTYLPAYTSLLRAPYTSDPFPLSSPPSTTTTTTTTTPPTSTITSTPTPDLPLLPSPHRETAILDAFIALKVREDVWADASELHLEREETFRDVFERVQPRARCEDLVRHYGERAGVVVLDAPGVADPSANGGGGSRTSRTRAIPFSALSVAFEPRRVALVLQPPAGERRRTIAEVPRAARDERLEVAAKRLVRELQAWIAEGGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2S5</accession>
    <name>W4K2S5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dystroglycan-type cadherin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_9532</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548722.1">
        <property type="nucleotide sequence ID" value="XM_009550427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2S5"/>
    <dbReference type="STRING" id="747525.W4K2S5"/>
    <dbReference type="GeneID" id="20678872"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_9532"/>
    <dbReference type="eggNOG" id="ENOG502QURR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012975_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2S5"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006644">
        <property type="entry name" value="Cadg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05345">
        <property type="entry name" value="He_PIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00736">
        <property type="entry name" value="CADG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="463"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="3">
        <location>
            <begin position="15"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="3">
        <location>
            <begin position="117"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="759"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="815"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW79356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="940" mass="100897" checksum="3F057F3AC3927F0B" modified="2014-03-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2X0</accession>
    <name>W4K2X0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prenyltransferase alpha-alpha toroid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_419734</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548678.1">
        <property type="nucleotide sequence ID" value="XM_009550383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2X0"/>
    <dbReference type="STRING" id="747525.W4K2X0"/>
    <dbReference type="GeneID" id="20673596"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_419734"/>
    <dbReference type="HOGENOM" id="CLU_2638358_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2X0"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="3">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW80162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="77" mass="8689" checksum="97A2AFB87BE7F009" modified="2014-03-19" version="1">MHFLYRTISMFSLLSRLNQLNRDKTIVYLMQSRSFDGGFRSIAGAETHIMQVHTVFMCTAVLAILDGLVIINLPTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4K353</accession>
    <name>W4K353_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_322581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548079.1">
        <property type="nucleotide sequence ID" value="XM_009549784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K353"/>
    <dbReference type="STRING" id="747525.W4K353"/>
    <dbReference type="GeneID" id="20670881"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_322581"/>
    <dbReference type="eggNOG" id="ENOG502RCSW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159031_0_0_1"/>
    <dbReference type="InParanoid" id="W4K353"/>
    <dbReference type="OrthoDB" id="2840473at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="15155" checksum="73780C36DEFC290F" modified="2014-03-19" version="1" fragment="single">MINAPKEYSSQLRIWQENVNTSDITQHGSLNTRAYDEYNVIAFQEPYIDFLGNTRASHDWHVLYPSTHLSSNEPKRSVLLIRSNLLSCSWRQIEFPSNDVTVVQFMGDFGILTLFNIYNDCNHRRTLNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4K393</accession>
    <name>W4K393_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_117292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548131.1">
        <property type="nucleotide sequence ID" value="XM_009549836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K393"/>
    <dbReference type="GeneID" id="20666545"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_117292"/>
    <dbReference type="eggNOG" id="ENOG502T20M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_30_1_1"/>
    <dbReference type="InParanoid" id="W4K393"/>
    <dbReference type="OrthoDB" id="3049938at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="19745" checksum="5AF330C5022C37E6" modified="2014-03-19" version="1">MSDKGNKPKDFDGTRSKYREWIYKCHIYILANLTKYDTDMNKTLMVLSYMREGTASLFAQKYYFDRELREYKATETKKTWGMFKDFLKELATAFKDESLEQKARQKLFTMRMGKRSADKFVTDYLMTAGESGFDLESTVDYFHRAIHLEILKQIHRLPDMPTTMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3B8</accession>
    <name>W4K3B8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450 monooxygenase 81</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cyp81</name>
        <name evidence="7" type="ORF">HETIRDRAFT_322517</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548370.1">
        <property type="nucleotide sequence ID" value="XM_009550075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3B8"/>
    <dbReference type="GeneID" id="20670866"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_322517"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022195_0_2_1"/>
    <dbReference type="InParanoid" id="W4K3B8"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW79825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="450" mass="50184" checksum="3D02DA6CDDCD845B" modified="2014-03-19" version="1">MYVTASPFTSRVRSFIPLHSSMPSPQSATQILSYITAVRYLFDGRKLTQEGYDKYKGGVFKIAMLDHWEVIASGPRAIEDISKAPTDTLSLLDAVQRTAEVDYTLVPEIRRDLYHIHIIRSRLTRGLNALFSDVREEVISAFNGLVPVTDEWVPYPAQETVMQIVSWASNRVFVGLLKCRDADFCALNVDFTIAVVKAVLVLNRFPDLMKSLASRLLTSIPSARAIHHLAPIIEERRAKQLALGDSWDDKPGQEQSVRNLAIRILTVNFTAIDTSSMSFTQTLYHFAANPEYACVLREEIESAVAEDGWTKHARERFSRAHRCRHTTILNCMPIPTSSIPGASPACANHTNSDDDLSALVRAKLQIVFTSTDFLFFGHGKHACPGRFFAAHEIKAMLAHVVVAYDVKFENGAADFPPNVFIGSASLPGKGQVIFRKRQVSDELTLAFLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4K427</accession>
    <name>W4K427_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger Mcm10/DnaG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_49497</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MCM10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547952.1">
        <property type="nucleotide sequence ID" value="XM_009549657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K427"/>
    <dbReference type="STRING" id="747525.W4K427"/>
    <dbReference type="GeneID" id="20678110"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_49497"/>
    <dbReference type="eggNOG" id="KOG3056">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015393_1_0_1"/>
    <dbReference type="InParanoid" id="W4K427"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040184">
        <property type="entry name" value="Mcm10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015408">
        <property type="entry name" value="Znf_Mcm10/DnaG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454:SF11">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09329">
        <property type="entry name" value="zf-primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger Mcm10/DnaG-type" evidence="3">
        <location>
            <begin position="431"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="272"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="482"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="591"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="674"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="741"/>
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                <person name="Lin Y.C."/>
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                <person name="Yakovlev I."/>
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            <dbReference type="EMBL" id="ETW80086.1"/>
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    </evidence>
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        <source>
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    </evidence>
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                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">May function both as a monomer and a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547583.1">
        <property type="nucleotide sequence ID" value="XM_009549288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4Z4"/>
    <dbReference type="FunCoup" id="W4K4Z4">
        <property type="interactions" value="377"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K4Z4"/>
    <dbReference type="GeneID" id="20672836"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_410101"/>
    <dbReference type="eggNOG" id="KOG2608">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023061_1_1_1"/>
    <dbReference type="InParanoid" id="W4K4Z4"/>
    <dbReference type="OrthoDB" id="269384at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF0">
        <property type="entry name" value="ERO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="ERO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845171" description="Endoplasmic oxidoreductin" evidence="16">
        <location>
            <begin position="23"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETW80888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="61422" checksum="7A3559CF9B7D1F66" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4K573</accession>
    <name>W4K573_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_61998</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546975.1">
        <property type="nucleotide sequence ID" value="XM_009548680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K573"/>
    <dbReference type="GeneID" id="20678577"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_61998"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_43_5_1"/>
    <dbReference type="InParanoid" id="W4K573"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000100">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF25">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="116"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW80957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="628" mass="70117" checksum="D22D05EEC71906A9" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6K8</accession>
    <name>W4K6K8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_434050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546085.1">
        <property type="nucleotide sequence ID" value="XM_009547790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6K8"/>
    <dbReference type="STRING" id="747525.W4K6K8"/>
    <dbReference type="GeneID" id="20674719"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_434050"/>
    <dbReference type="eggNOG" id="ENOG502QSMW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028123_2_1_1"/>
    <dbReference type="InParanoid" id="W4K6K8"/>
    <dbReference type="OrthoDB" id="5977668at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3110.10">
        <property type="entry name" value="protoporphyrinogen ix oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.20">
        <property type="entry name" value="Protoporphyrinogen oxidase, mitochondrial, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF17">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="521" mass="58149" checksum="C1441E42857A24FA" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6T6</accession>
    <name>W4K6T6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_146467</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547735.1">
        <property type="nucleotide sequence ID" value="XM_009549440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6T6"/>
    <dbReference type="FunCoup" id="W4K6T6">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K6T6"/>
    <dbReference type="GeneID" id="20667137"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_146467"/>
    <dbReference type="eggNOG" id="KOG0752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_10_9_1"/>
    <dbReference type="InParanoid" id="W4K6T6"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="35"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="133"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="265"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW81055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="360" mass="38425" checksum="D22F4E156BB7B590" modified="2014-03-19" version="1">MTSEQQQSSKVSTGDSVSTAPASEPAKAPAPFLSPQISSYFIAGGVAGAASRTVVSPLERLKIIQQVQPRTGDAKQYKGVWSSLVRMFKEEGFRGFMRGNGINCVRIIPYSAVQFTTYEQLKKWFTQNGARELDTPTRLVSGALAGITSVCTTYPLDLIRSRLSIATASIVSSSPSPTPSSAAAPAQPALASAYHTSSAASSAALRSRSELTMWGMTLKVIREEGGVRALYRGMVATATGVAPYVGINFASYELLRGIVTPPGKSSVVRKLSCGALAGAVSQTITYPFDVVRRKMQVSGMSSSALGYKYSSAIDATRSIIRNEGVRGMYRGLWPNLLKVAPSIATSFFTYELVKEFLLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4K713</accession>
    <name>W4K713_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_104919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546229.1">
        <property type="nucleotide sequence ID" value="XM_009547934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K713"/>
    <dbReference type="GeneID" id="20666037"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_104919"/>
    <dbReference type="HOGENOM" id="CLU_950137_0_0_1"/>
    <dbReference type="InParanoid" id="W4K713"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="293" mass="30490" checksum="1A617636B4FF3029" modified="2014-03-19" version="1">MFRISTYRRDPSALVWYACVLGAARARLSALKAARSDLVARGSSGAGRALCAVGAEASRDGARSAFCALDHADGIAALSGCARRASDFSTYTTLSYVSIANPPPLPPSPPAPEAHALWRSGRVRPPAGTANANESRKRIEQPPVAPSITASLSLSLSLLSRVAGPSSHRLVARASLRPRCPSLEASSSLPPFASASMPDTPSHAMSSARAISILTHTHTPSRPLPSAGRYIRVPPRSARSSRTDVGARSFAAATSTRACVAPPIAARAKKEIDRTGHRAMIEDAFSALGAPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7H9</accession>
    <name>W4K7H9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lysosomal cystine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_451118</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545958.1">
        <property type="nucleotide sequence ID" value="XM_009547663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7H9"/>
    <dbReference type="STRING" id="747525.W4K7H9"/>
    <dbReference type="GeneID" id="20676117"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_451118"/>
    <dbReference type="eggNOG" id="KOG3211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053568_0_0_1"/>
    <dbReference type="InParanoid" id="W4K7H9"/>
    <dbReference type="OrthoDB" id="271506at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000006">
        <property type="entry name" value="mannose-P-dolichol utilization defect 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW81285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="308" mass="33393" checksum="4428F7337F783A62" modified="2014-03-19" version="1">MSAITKNLPWFVRDLGVTVVGEKCYVSLVENLHLEDVECLKYSLSKGLGIGIVVGGSIMKIPQLLLILNARSVRGLSLPAYVLETLAYAITLAYSYRNGFPFSTYGENLFLTLQNVVITLLIVYYQAAYTPHRALTTSHPRPTTRLVSLSLATLIAGIALIAAPPALLALLQLATLPLSLFSKLPQIAQNHRARSTGQLSAFAVLAQVGGCAARLFTTATEVGDIVVSAGFALALLLNLVLGMQMYAYWGKDLPSEAPIRQPFEEKTLEKPTSRVDIVVPPQSPAAHQTAHLQPQPASYGRKWARKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7Q6</accession>
    <name>W4K7Q6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_475336</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546419.1">
        <property type="nucleotide sequence ID" value="XM_009548124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7Q6"/>
    <dbReference type="GeneID" id="20677621"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_475336"/>
    <dbReference type="eggNOG" id="ENOG502QQS7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032740_0_0_1"/>
    <dbReference type="InParanoid" id="W4K7Q6"/>
    <dbReference type="OrthoDB" id="9909311at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF70">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="95"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="305"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW81818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="436" mass="48478" checksum="361AA638D4F50CF9" modified="2014-03-19" version="1">MTTAASSTSGHNPQQFSGSPPDNLSPTAPKMDANKPRKQRLYNVDRKAICVYHKENPTMRQEDIALKYGVERSTISKILKQKQKWLNVPDGEEVLVAKQRPSKFPEIEAELVKWLFECKDRRVVLSDCLIRSKAREVARQMEISDDKFKASSGWVENFKNRHGIRKGVWEGNGRNAQVIRAQGGSALHEDEDEEPHPTLADYIYQHNLYDLDETLKPVRRSHKQSVPSGIPAESRVRENDSENPETDAIGANLGSHQDIDEARQAMEATTAQSLGHIHSPEHIQSPVVENPSTAQAHLDVDNSFSSVSTHLSDSLSHSQHMESPQVHVSTSSPAILSRFPDSSDVSMHIESSAQAAQTSPLQYFDMYPPPPGPQLSIPEYADTLGSLDKVMRFVDAQPQGFLRQDDHQALTRIKLAVLAMGSRGGPPPDLEAPQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8F7</accession>
    <name>W4K8F7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450 monooxygenase 108</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">cpm108</name>
        <name evidence="12" type="ORF">HETIRDRAFT_46257</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545818.1">
        <property type="nucleotide sequence ID" value="XM_009547523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8F7"/>
    <dbReference type="GeneID" id="20677182"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_46257"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_3_1"/>
    <dbReference type="InParanoid" id="W4K8F7"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW82117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="519" mass="58975" checksum="CCC0C847D906AACB" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8Q8</accession>
    <name>W4K8Q8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_451236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546091.1">
        <property type="nucleotide sequence ID" value="XM_009547796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8Q8"/>
    <dbReference type="GeneID" id="20676127"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_451236"/>
    <dbReference type="HOGENOM" id="CLU_1337649_0_0_1"/>
    <dbReference type="InParanoid" id="W4K8Q8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="205" mass="21568" checksum="CCAE5CFEB66DB969" modified="2014-03-19" version="1">MPIPFLGSPLVCLRVQASDRDGIRDAIISTLAPAASSPSPLRGRWQLSPRSASASASASPTLFLHLALTLTPLAGRPLCGPSARSFRALVRRVQCVRRVPRHAASATLSHRGRVQMTRAQLSAPPFSCPPTHSRAPAPHAPPTALLAPNPPAARASDPSRAASSDPHRVTTPTLAIPVTHRHQRAPRACAPITHSHSHPPSPVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9L4</accession>
    <name>W4K9L4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RecF/RecN/SMC N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HETIRDRAFT_36823</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545787.1">
        <property type="nucleotide sequence ID" value="XM_009547492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9L4"/>
    <dbReference type="FunCoup" id="W4K9L4">
        <property type="interactions" value="528"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K9L4"/>
    <dbReference type="GeneID" id="20671831"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_36823"/>
    <dbReference type="eggNOG" id="KOG0250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009063_0_0_1"/>
    <dbReference type="InParanoid" id="W4K9L4"/>
    <dbReference type="OrthoDB" id="10072614at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="14">
        <location>
            <begin position="9"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="672"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="924"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="248"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="773"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="691"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="924"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETW81761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1039" mass="118655" checksum="CC77DB3FB3CE58CE" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9V3</accession>
    <name>W4K9V3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphoglucomutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HETIRDRAFT_317679</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546434.1">
        <property type="nucleotide sequence ID" value="XM_009548139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9V3"/>
    <dbReference type="FunCoup" id="W4K9V3">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K9V3"/>
    <dbReference type="GeneID" id="20670438"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_317679"/>
    <dbReference type="eggNOG" id="KOG1220">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_0_1_1"/>
    <dbReference type="InParanoid" id="W4K9V3"/>
    <dbReference type="OrthoDB" id="8300170at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008973">
        <property type="term" value="F:phosphopentomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05799">
        <property type="entry name" value="PGM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000035">
        <property type="entry name" value="Pgm3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745:SF1">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745">
        <property type="entry name" value="PHOSPHOMANNOMUTASE 45A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="12">
        <location>
            <begin position="45"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="13">
        <location>
            <begin position="224"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="14">
        <location>
            <begin position="327"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETW81836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="595" mass="66168" checksum="F35A71F579335BB8" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4KA08</accession>
    <name>W4KA08_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_317056</name>
        <name evidence="3" type="ORF">HETIRDRAFT_318623</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546492.1">
        <property type="nucleotide sequence ID" value="XM_009548197.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546530.1">
        <property type="nucleotide sequence ID" value="XM_009548235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KA08"/>
    <dbReference type="GeneID" id="20670385"/>
    <dbReference type="GeneID" id="20670525"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_317056"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_318623"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_4_2_1"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="172"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW81901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW81940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="326" mass="36861" checksum="24176CE2C448F80E" modified="2014-03-19" version="1">MSETTTPPFPDAIPVAPLLVINHALIKAGDRDEIDKLWKAATELGFWYTKNHGMDKEVEDMYELSMKTLELPLEEKIKSEGHKRNGRWVTDETGSPDNIEFMDIAKDDILAWPERILRSYPHTVNDLTIESTLKPYLLKSLDLCFTAFNIFDGKFGLPGGRLVQNHTGDNISRSEIRCIRCLPRPEVPAHKLSLGVHTDFGSMTILHPRLGGLQVLPPGSSEWLYVKPVPGYVICNLGDAMAIWSGGILRSNQHRVVNPPKEQASLVRWSHGYFTRPNDNCILAPLVTKARRSHNMRLRKPIGRRIPTCDLRPRLTGMSDGTILWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAV0</accession>
    <name>W4KAV0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_427309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546748.1">
        <property type="nucleotide sequence ID" value="XM_009548453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAV0"/>
    <dbReference type="GeneID" id="20674197"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_427309"/>
    <dbReference type="eggNOG" id="ENOG502SV4M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079112_0_0_1"/>
    <dbReference type="InParanoid" id="W4KAV0"/>
    <dbReference type="OrthoDB" id="3239749at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="306" mass="34345" checksum="2D794EC095F6BB03" modified="2014-03-19" version="1">MSTPENTTETSFSTFVHGQQGDDVSSVTPSQTSNVEQGVEHHDIFMPTMGPAIRTPPIVRDIVVTKYSVQWLNLSLPEQGFYAKNHMVAALDSAQPWTIDGITYYNSARISMELGVEMQSADVIGQEDWVSGENYFPGEYAVRLFKTDELFDLVVYHLTYNDRTGATIGDFIDEVLERDMHHFLFLPYTASGHWKGCGDHIIHTFAVFVDEGLLPTTDSNEHPTVPLSTELTYTYFAGGKNTWCRMGRGWWLKYNPPTDPLTPETSFSEGRLTWQLPTAPQSVQQDTQEEVGEGEPSVKSDNDEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBB8</accession>
    <name>W4KBB8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase family 31 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_474666</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546868.1">
        <property type="nucleotide sequence ID" value="XM_009548573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBB8"/>
    <dbReference type="STRING" id="747525.W4KBB8"/>
    <dbReference type="GeneID" id="20677580"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_474666"/>
    <dbReference type="eggNOG" id="KOG1065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087034_0_0_1"/>
    <dbReference type="InParanoid" id="W4KBB8"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF133">
        <property type="entry name" value="P-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="4">
        <location>
            <begin position="58"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW82341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="279" mass="30209" checksum="61D01950B10510A1" modified="2014-03-19" version="1">MQLSAFTMFYRKHNQRGALSQEPYRWDSVANASKTAVSIRYALLPYWYTLFANASTNGTPHVRALFFEFPDEPELFAVDRQFMVGSDILVTPVLEPNVTTVDGIFLGRGQITWRDWYTHTAVNATVGAPTTLSAPLGHINVHIRAGAALLTHAQPAYTTRETRAGPYALLVALGVDGAAYGTAYLDDGTSLPLPDSPIANRTVRFIVHAGALTIESTGTFRVEQPLARVTVLGVPSAPGSVFVGGQEAARGGYTYNADVEQLLMDGLAVNLNNGHLSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBE5</accession>
    <name>W4KBE5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_450741</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545334.1">
        <property type="nucleotide sequence ID" value="XM_009547039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBE5"/>
    <dbReference type="STRING" id="747525.W4KBE5"/>
    <dbReference type="GeneID" id="20676073"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_450741"/>
    <dbReference type="eggNOG" id="ENOG502SK5F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1337648_0_0_1"/>
    <dbReference type="InParanoid" id="W4KBE5"/>
    <dbReference type="OrthoDB" id="2399539at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="81"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW83049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="205" mass="22488" checksum="D6295FBE79053F88" modified="2014-03-19" version="1">MASLSAHFTPCFAACYSDPDCATEHFMLQAVGLVLHEMYKPSLERTQGSCVLPALPSTAPPSDCPHFLLSVTECHGDRDRSFMHMGIAARMAGLLRLHREETYRLLPDASAEDVIASEVARRTFWMIASQDNLQSAMNTPAPFLLRNISALLPCDEQDFALGSALHAREPSRSNNSTLIGTPSRSLFAVLIQAHNLRGQVTHHAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCJ1</accession>
    <name>W4KCJ1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">WLM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_450748</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545344.1">
        <property type="nucleotide sequence ID" value="XM_009547049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCJ1"/>
    <dbReference type="STRING" id="747525.W4KCJ1"/>
    <dbReference type="GeneID" id="20676074"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_450748"/>
    <dbReference type="eggNOG" id="KOG4842">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040077_0_0_1"/>
    <dbReference type="InParanoid" id="W4KCJ1"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053000">
        <property type="entry name" value="WSS1-like_metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WLM" evidence="7">
        <location>
            <begin position="8"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="493"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="370"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="453"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="411"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW83060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="57189" checksum="2E9B8DBBE4013FB3" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4KD56</accession>
    <name>W4KD56_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_432829</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543480.1">
        <property type="nucleotide sequence ID" value="XM_009545185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KD56"/>
    <dbReference type="STRING" id="747525.W4KD56"/>
    <dbReference type="GeneID" id="20674635"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_432829"/>
    <dbReference type="eggNOG" id="ENOG502QR3J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028760_7_0_1"/>
    <dbReference type="InParanoid" id="W4KD56"/>
    <dbReference type="OrthoDB" id="444135at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001209">
        <property type="entry name" value="PRK00175.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF16">
        <property type="entry name" value="SERINE O-SUCCINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="125"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="9"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW83723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="497" mass="53967" checksum="62C28B6D44EB7C08" modified="2014-03-19" version="1">MTSRIPLKPAGLASRLARSASRSPRVQTTRPSSSFSTPSRSPERPVFPCVEQHAARQSRILSSLASTSSDPSSSGPEPPYARPAPQSYKTYHHRAPMPLTYAAPLPEFTVAYETWGTLSPSRDNVLLLHTGLSASSHAASTPANPAEGWWEKFIGPGRAIDTNQFFVVCTNVLGGCYGTTGPSSVDPATGDPYATRFPVVSIFDMVRAQFCLLDHLGVDKLYASVGSSMGAMQSLAAGWLFPERVGKVVSISGTARSSPGSVAMRYAQRSVLMADPNWNNGFYYDRLPPHTGLKLARQIATITYRSGPEWDIRFGRQLKPQRPEVELTADPSLPRTPALCPDFLIETYLDHQGEQFCLKYDANSLIYISKAMDLFDLTRPALEALKITPAPPSKSAAIASLPHRTSHSKSHPPPSNPPAYLPDLAAGLRPLAHTPVLVLGVQSDILFPVEQQREVADALRMAGNERVSYYELGGVWGHDTFLLDVQNVGGALRGFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDM2</accession>
    <name>W4KDM2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase family 32 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_34312</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
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        <property type="protein sequence ID" value="ETW83893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009544870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDM2"/>
    <dbReference type="GeneID" id="20671773"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_34312"/>
    <dbReference type="eggNOG" id="ENOG502QS3D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016900_0_0_1"/>
    <dbReference type="InParanoid" id="W4KDM2"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000005">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.17, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF15">
        <property type="entry name" value="INOSITOL PHOSPHOCERAMIDE MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="463"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="474"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="508"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="532"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW83893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="546" mass="61183" checksum="E9296103FE0C9884" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEI2</accession>
    <name>W4KEI2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF2415 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_458773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545717.1">
        <property type="nucleotide sequence ID" value="XM_009547422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEI2"/>
    <dbReference type="STRING" id="747525.W4KEI2"/>
    <dbReference type="GeneID" id="20676946"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_458773"/>
    <dbReference type="eggNOG" id="KOG4532">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005870_0_0_1"/>
    <dbReference type="InParanoid" id="W4KEI2"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF9">
        <property type="entry name" value="DUF2415 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="533"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="781"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="857" mass="90651" checksum="9527FFAA32576D35" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFA9</accession>
    <name>W4KFA9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Glutamine synthetase</fullName>
            <ecNumber evidence="4 13">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HETIRDRAFT_381300</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homooctamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="4 13"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543717.1">
        <property type="nucleotide sequence ID" value="XM_009545422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFA9"/>
    <dbReference type="FunCoup" id="W4KFA9">
        <property type="interactions" value="518"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KFA9"/>
    <dbReference type="GeneID" id="20672064"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_381300"/>
    <dbReference type="eggNOG" id="KOG0683">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036762_1_1_1"/>
    <dbReference type="InParanoid" id="W4KFA9"/>
    <dbReference type="OrthoDB" id="1936100at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="14">
        <location>
            <begin position="22"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="15">
        <location>
            <begin position="108"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETW83995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="354" mass="39305" checksum="DA2EDC6164609A9B" modified="2014-03-19" version="1">MAFQYRPDLLAPYLALPQGEKVQAEYVWIDGDGGLRSKTTTVPKKVTDIGQLRIWDFDGSSTNQAPGNDSDVYLRPAAIFKDPFRGGDNILVLAETYNNDGTPNMTNYRHHAKKVMDLAKDSVPWFGLEQEYTLFDVDGTPYGWPKGGFPGPQGPYYCGAGTGKVFARDLIEAHYRACLYAGVNISGINAEVMPSQWEFQVGPCEGISMGDHLWMARYLLTRVAEQWGVKVSLHPKPLQGEWNGAGCHTNFSTKEMREPGGIKHIDSAIEKLSKRHDEHIAVYGEDNELRLTGRHETGHISSFSSGVANRGASIRVPRHVAAQGYGYLEDRRPASNIDPYRVTSIIVETTVLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFD9</accession>
    <name>W4KFD9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_311740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544224.1">
        <property type="nucleotide sequence ID" value="XM_009545929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFD9"/>
    <dbReference type="GeneID" id="20669894"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_311740"/>
    <dbReference type="eggNOG" id="ENOG502SNH4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030728_0_0_1"/>
    <dbReference type="InParanoid" id="W4KFD9"/>
    <dbReference type="OrthoDB" id="3208379at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="52078" checksum="A8BC523998409803" modified="2014-03-19" version="1">MTADSTPHLSDSRGSKLVYDAHHPTHASVPPGWDMYIHPQGWVYFTNPVAKVVTDEDVRIPAVLQDIEKYTATFPLSELDEHMEILVPCGALPKEHILTLVVNHLHCTASYTIDQAKAENFPQLERYMVNKQHRLYWNYLSAHPVHVPTPVIAEAQVRDALTWYQIDNLNTGARSVVPFSKTECEDLLRTLNDAKVGTSSEASVSRTVFLSWVSREIWSFRDAERYGRYTKRQSNELRAAGKRPEPESVPALPIYIRLPLDFVVYLAFFGIPSTYLAHVKDASEYHGRLSNIQWRWERYIDRIVQEYQDFLLIFLTARLCSANVSFLAIGDIGATGQAAGVVSVFASMGSIIVGVFCVWKHQANRHQSRSFAYLHNAHHGILGLQGHALTLSLPPVLLVWAVIAFAVAFLAYTIDGTYNPSKLGQAAAWATLGVSLVVLLFIVVGLYTFARIWKWRSRWRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFI0</accession>
    <name>W4KFI0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosidase 2 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_473353</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544264.1">
        <property type="nucleotide sequence ID" value="XM_009545969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFI0"/>
    <dbReference type="FunCoup" id="W4KFI0">
        <property type="interactions" value="670"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KFI0"/>
    <dbReference type="GeneID" id="20677512"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_473353"/>
    <dbReference type="eggNOG" id="KOG2397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016834_2_0_1"/>
    <dbReference type="InParanoid" id="W4KFI0"/>
    <dbReference type="OrthoDB" id="28322at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036607">
        <property type="entry name" value="PRKCSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028146">
        <property type="entry name" value="PRKCSH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF1">
        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12999">
        <property type="entry name" value="PRKCSH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13015">
        <property type="entry name" value="PRKCSH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845361" description="Glucosidase 2 subunit beta" evidence="6">
        <location>
            <begin position="21"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="7">
        <location>
            <begin position="433"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW84617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="551" mass="60747" checksum="BC7498F2343E8138" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFX4</accession>
    <name>W4KFX4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_47230</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="5"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543207.1">
        <property type="nucleotide sequence ID" value="XM_009544912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFX4"/>
    <dbReference type="GeneID" id="20677451"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_47230"/>
    <dbReference type="eggNOG" id="ENOG502S9FN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065200_6_2_1"/>
    <dbReference type="InParanoid" id="W4KFX4"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW84743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="137" mass="15627" checksum="40B49C753A662CF3" modified="2014-03-19" version="1" fragment="single">YIAGWLLQITGTLIRLACYRALGRQFTFELAIRDEHKLVTSGAYAVVRHPAYAGSIMVLSGTLLCTFGPGSWIRECGWLETVAMQCVAALFAGWASWIVFYQIKRTRVEDDALREKFRGDWEDWAERVSYRLVPGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4KG35</accession>
    <name>W4KG35_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">6-O-methylguanine-DNA methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_312510</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = S-methyl-L-cysteinyl-[protein] + a 2'-deoxyguanosine in DNA</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="3"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544411.1">
        <property type="nucleotide sequence ID" value="XM_009546116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KG35"/>
    <dbReference type="GeneID" id="20669962"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_312510"/>
    <dbReference type="eggNOG" id="ENOG502S8GR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_52_3_1"/>
    <dbReference type="InParanoid" id="W4KG35"/>
    <dbReference type="OrthoDB" id="1907495at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815:SF13">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="12">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW84782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="110" mass="11799" checksum="1BC3550D4EE50A87" modified="2014-03-19" version="1" fragment="single">VYDLILKVPAGKISTYKAICAALGSGSPRSVGTALRNNPFAPFVPCHRVVASNFFVGGFFGEWTDLKGGANKGKRKVRMLVQEGIPFTAEGRLVRGEKYLWAGPDAVVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGD9</accession>
    <name>W4KGD9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Beta-mannosidase B</fullName>
            <ecNumber evidence="5">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mannanase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HETIRDRAFT_109221</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="5"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544549.1">
        <property type="nucleotide sequence ID" value="XM_009546254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGD9"/>
    <dbReference type="STRING" id="747525.W4KGD9"/>
    <dbReference type="GeneID" id="20666422"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_109221"/>
    <dbReference type="eggNOG" id="KOG2230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005015_1_1_1"/>
    <dbReference type="InParanoid" id="W4KGD9"/>
    <dbReference type="OrthoDB" id="2866996at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000050">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041625">
        <property type="entry name" value="Beta-mannosidase_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17753">
        <property type="entry name" value="Ig_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="16">
        <location>
            <begin position="26"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="13">
        <location>
            <begin position="233"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="15">
        <location>
            <begin position="711"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase Ig-fold" evidence="14">
        <location>
            <begin position="814"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETW84928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="882" mass="99995" checksum="D3E9BEA2E86DAA72" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4KH30</accession>
    <name>W4KH30_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2423 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_123946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544022.1">
        <property type="nucleotide sequence ID" value="XM_009545727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KH30"/>
    <dbReference type="STRING" id="747525.W4KH30"/>
    <dbReference type="GeneID" id="20666851"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_123946"/>
    <dbReference type="HOGENOM" id="CLU_125052_0_0_1"/>
    <dbReference type="InParanoid" id="W4KH30"/>
    <dbReference type="OrthoDB" id="4087970at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019434">
        <property type="entry name" value="DUF2423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28219">
        <property type="entry name" value="UPF0642 PROTEIN YBL028C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28219:SF1">
        <property type="entry name" value="UPF0642 PROTEIN YBL028C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10338">
        <property type="entry name" value="YBL028C_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2423" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW84341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="94" mass="10671" checksum="46FF7EAF1631872B" modified="2014-03-19" version="1">MAKSTRSKVKRAYRSKKRTEGVYHALEAARLQRLSAKLCGLAASKRISTHGPRNSRREQWRASKGLEARPKARGMTRQGTVAARRKSGRPSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4KI75</accession>
    <name>W4KI75_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_414574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542410.1">
        <property type="nucleotide sequence ID" value="XM_009544115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KI75"/>
    <dbReference type="GeneID" id="20673187"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_414574"/>
    <dbReference type="HOGENOM" id="CLU_024199_2_3_1"/>
    <dbReference type="InParanoid" id="W4KI75"/>
    <dbReference type="OrthoDB" id="2884925at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="30"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="553" mass="62430" checksum="5AC4A90BBCFA3A4B" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4KI79</accession>
    <name>W4KI79_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxisomal ATPase PEX6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peroxin-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_154483</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542415.1">
        <property type="nucleotide sequence ID" value="XM_009544120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KI79"/>
    <dbReference type="FunCoup" id="W4KI79">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KI79"/>
    <dbReference type="GeneID" id="20667497"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_154483"/>
    <dbReference type="eggNOG" id="KOG0736">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_0_0_1"/>
    <dbReference type="InParanoid" id="W4KI79"/>
    <dbReference type="OrthoDB" id="5553750at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19527">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000109">
        <property type="entry name" value="Peroxisomal biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000039">
        <property type="entry name" value="peroxisome biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056995">
        <property type="entry name" value="PEX6_4th_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047533">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF9">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23315">
        <property type="entry name" value="PEX6_4th"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="331"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="607"/>
            <end position="747"/>
        </location>
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            <end position="112"/>
        </location>
    </feature>
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            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
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            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="140" mass="15639" checksum="D626490C5BC40C46" modified="2014-03-19" version="1">MSPSTIYPSTLPAPSSRPLNLSHIRPALPSDPLDPIARCTALPALLARSHAHWPTGRLARIVHIASRIACVARTHARLTRISRSTPRSPARSSSRPPPSTTPTRPPPPPPPLYLLRLLRCRHHHHPHHHHHRFLHLTPLL</sequence>
</entry>
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        </recommendedName>
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        <name evidence="2" type="ORF">HETIRDRAFT_407615</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIY5"/>
    <dbReference type="GeneID" id="20672613"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_407615"/>
    <dbReference type="eggNOG" id="KOG3947">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="630188at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
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        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
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        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
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        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="28"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW85684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="262" mass="28910" checksum="91FB74A340DC264C" modified="2014-03-19" version="1">MATVHIDYGDHVPPHPGTRSGWTRFVCISDTHSHIVPVPPGDVLIHAGDLSSWGTLKQLKTTIDWLMTLPHPTKVIIAGNHDLCLDRAWVEGKSSHRVQSTITSKDAEEARTMIRSQAVRNAGIHYLEYESLELSTSSGKVWKIYGSPACPRFAPGCFQYTTKDEAEDIYSQIPPDTEILITHTPPYHTLDQSRKGVHAGCKTLATKVGQLKPCRLHVFGHIHEANGAHMHQGNPDEGLPDRVSVNGAWGDHSTVIVDLKDD</sequence>
</entry>
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        <recommendedName>
            <fullName evidence="4">Phorbol-ester/DAG-type domain-containing protein</fullName>
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    </protein>
    <gene>
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    </gene>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Solheim H."/>
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                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009544401.1"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KJ66"/>
    <dbReference type="GeneID" id="20669870"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_311440"/>
    <dbReference type="eggNOG" id="KOG4820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001302_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJ66"/>
    <dbReference type="OrthoDB" id="6270916at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="4">
        <location>
            <begin position="614"/>
            <end position="668"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="189"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="978"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="996"/>
            <end position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW85887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="2333" mass="260415" checksum="A4FE84B0BFFCAEC2" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJC5</accession>
    <name>W4KJC5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_407400</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009543753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJC5"/>
    <dbReference type="GeneID" id="20672594"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_407400"/>
    <dbReference type="HOGENOM" id="CLU_1482161_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJC5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="182" mass="18799" checksum="6747981168521817" modified="2014-03-19" version="1">MPPTSPWPAPPPPVQPAYGGYAPYAPHPGAYPQQYAPPGPWPAGPPPGPPPAMYTPAPQYSQPYPPPQQHNGWNGYPGGPQAGYSGGPQAGYPGGPPGGYPGGPLGGYPGGPPGGYPSGGYPGGPPPGWGQPPPQRAQMPPRTRDRADKIDRFAAGPHCSSVLLSCWERSVMNHHHVQMALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJK8</accession>
    <name>W4KJK8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_432558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542822.1">
        <property type="nucleotide sequence ID" value="XM_009544527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJK8"/>
    <dbReference type="GeneID" id="20674617"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_432558"/>
    <dbReference type="HOGENOM" id="CLU_2073455_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJK8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="118" mass="12658" checksum="6C88292929E96854" modified="2014-03-19" version="1">MRCGAMRWWVDTVRCGAAWPCTCACAVYRPGARAVGERDAGEERWDRRDAGVRTSGAAPDARAVVFALCLPFVEGVGSGLVRVRPTGAHRGGSTDSVVALGRERKEGSRELDPMTHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKY0</accession>
    <name>W4KKY0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_415277</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543089.1">
        <property type="nucleotide sequence ID" value="XM_009544794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKY0"/>
    <dbReference type="FunCoup" id="W4KKY0">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="GeneID" id="20673235"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_415277"/>
    <dbReference type="eggNOG" id="KOG1293">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002741_0_0_1"/>
    <dbReference type="InParanoid" id="W4KKY0"/>
    <dbReference type="OrthoDB" id="5559898at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038739">
        <property type="entry name" value="ARMC8/Vid28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651:SF7">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW86344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="776" mass="84894" checksum="F7F0A95DCCE43EBE" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKY6</accession>
    <name>W4KKY6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_471290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542802.1">
        <property type="nucleotide sequence ID" value="XM_009544507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKY6"/>
    <dbReference type="FunCoup" id="W4KKY6">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KKY6"/>
    <dbReference type="GeneID" id="20677388"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_471290"/>
    <dbReference type="eggNOG" id="KOG2197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004457_0_1_1"/>
    <dbReference type="InParanoid" id="W4KKY6"/>
    <dbReference type="OrthoDB" id="10264062at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000077">
        <property type="entry name" value="TBC1 domain family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021935">
        <property type="entry name" value="SGSM1/2_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF502">
        <property type="entry name" value="SMALL G PROTEIN SIGNALING MODULATOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12068">
        <property type="entry name" value="PH_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
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            <end position="557"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW86015.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="833" mass="93706" checksum="D9E9C14B73080AD6" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4KL34</accession>
    <name>W4KL34_HETIT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_167724</name>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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            <taxon>Heterobasidion</taxon>
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    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_167724"/>
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            <end position="138"/>
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    </feature>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW86065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="309" mass="33572" checksum="C83EF3BF7681E1A8" modified="2014-03-19" version="1">MIASSARFYRKKYLHQRGLFERLKSEVAETMSLRKINEELRSENEQLRQYAGISGPGSATASSENGKRRRTDAYRSGTEARDLSSPHSVSNLLGPNRLTLPANHQQPKFTQQLSNSDANSHSNRGTAQDQQRDRPGSSRFVQQYAYVPPQTPQQQNASSMSQSTPIHQIHPRNNSLMPPPPTPVMRNAQGGALRSDSLSIASISRSSVQMPRPTNALVSTQHPPSRFGFPPGSKSSGAYLTSSANSNRFIPSTSSGVPSQQAGFIPQTPSGGSRRFLPPASGSRAPSRAAGTPSHNNQSPRLPFVPQYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMJ4</accession>
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        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <lineage>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Velez H."/>
                <person name="de Vries R.P."/>
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                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_153681"/>
    <dbReference type="eggNOG" id="ENOG502RPVK">
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    </dbReference>
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    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="prtT"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="47"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="172"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="342"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="775"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="15"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW86919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="899" mass="99775" checksum="91917880243CA44E" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4KN86</accession>
    <name>W4KN86_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS17 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_406926</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
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        <property type="protein sequence ID" value="ETW87184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009542820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KN86"/>
    <dbReference type="FunCoup" id="W4KN86">
        <property type="interactions" value="397"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KN86"/>
    <dbReference type="GeneID" id="20672552"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_406926"/>
    <dbReference type="eggNOG" id="KOG1728">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073626_0_2_1"/>
    <dbReference type="InParanoid" id="W4KN86"/>
    <dbReference type="OrthoDB" id="10254436at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1000:FF:000001">
        <property type="entry name" value="40S ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_uS17_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_uS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="5">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW87184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="153" mass="17553" checksum="0CBA6C9317695DDD" modified="2014-03-19" version="1">MADQIEKAFQKQPLFQNTKTRVGKKVSTKDKRWYKDVGLGFKTPSDAISGTYIDKKCPFTGEVSIRGRILTGRVVSTKMTRTIVIRRDYLHYIPKYNRYEKRHKNLAAHLSPAFRVDVGDIVTVGQCRPLSKTVRFNVLRVSKNKAAVKFGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNA3</accession>
    <name>W4KNA3_HETIT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_447255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540547.1">
        <property type="nucleotide sequence ID" value="XM_009542252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNA3"/>
    <dbReference type="GeneID" id="20675752"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_447255"/>
    <dbReference type="HOGENOM" id="CLU_729694_0_0_1"/>
    <dbReference type="InParanoid" id="W4KNA3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="379" mass="43197" checksum="FE641B3DEBEC0115" modified="2014-03-19" version="1">MPRLHLETPPPMSSLWSPIQTSDEWIEEPVLTQAMLDELIEEPVLTAQSPPSSPSLHTSITSQITTPRTTPSSKKEKELANRHPRGPHEMHHGMKTLMTETYRALMKYQWEFHLLLQSRRALELQVPRDYEQEQQLNSQAMEKLNRYQLYRELHLRQYQLVDRFPAPWEELPLRSTISAGNPGMRIATYLDNWLVPVSRSEDSPSKQTLTQPLGTNITTDDHELSSSIPMNSPSMSTESSFQLSSSPENWAPSNQVEPTLSTLSFGMYHVPENHIAIPRRPPLTGYEIFPYPMGVPTRRNHPSIEETREEGVEEPRQPSAAEQLLAGVFDTGLERLLIVLDFVQTRDRITEVAAELAALIWRLEEITLGLDPSSMHGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNM8</accession>
    <name>W4KNM8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_99403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540951.1">
        <property type="nucleotide sequence ID" value="XM_009542656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNM8"/>
    <dbReference type="STRING" id="747525.W4KNM8"/>
    <dbReference type="GeneID" id="20678903"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_99403"/>
    <dbReference type="eggNOG" id="ENOG502RWPB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_319349_0_0_1"/>
    <dbReference type="InParanoid" id="W4KNM8"/>
    <dbReference type="OrthoDB" id="298939at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="344"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="910"/>
        </location>
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                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
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                <person name="Broberg A."/>
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                <person name="Cullen D."/>
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                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Gonthier P."/>
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                <person name="Fossdal C.G."/>
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                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
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                <person name="Yakovlev I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
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    </evidence>
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<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Asiegbu F."/>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="Deflorio G."/>
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                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
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                <person name="James T.Y."/>
                <person name="Karlsson M."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW74849.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
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    </evidence>
    <sequence length="275" mass="30002" checksum="9B389EFD4241CFF8" modified="2014-03-19" version="1">MGSVSTSSISTAGAISEDAGALSASLSSEGKGNGKSDFGEDGGQERSTGANDNSTEGGDEGDEVEVEEGEDKADRIKSNNSSSFDPTLGDGEDEEEGDEGERVVFELVLDTPAPAGYKKERMELTREEHDEAKKLENERKEGRELHGEGDSTNESDVGRSAIQQEWTTSWRTSERTKEHEQLSREVHRPGHAVRALYSPEIFAPHFEAERRQPTKVLTSQASTSHAPAKGKSKGKQIWTLAPLRAHLATVHLHTIARRRDWAHAGRLGRERDGTS</sequence>
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<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 12 protein</fullName>
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        <name evidence="4" type="primary">gh12.4</name>
        <name evidence="4" type="ORF">HETIRDRAFT_56987</name>
    </gene>
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        <lineage>
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                <person name="Asiegbu F."/>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553052.1">
        <property type="nucleotide sequence ID" value="XM_009554757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNZ4"/>
    <dbReference type="STRING" id="747525.W4JNZ4"/>
    <dbReference type="GeneID" id="20678380"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_56987"/>
    <dbReference type="eggNOG" id="ENOG502SH4Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051064_1_2_1"/>
    <dbReference type="InParanoid" id="W4JNZ4"/>
    <dbReference type="OrthoDB" id="89349at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF9">
        <property type="entry name" value="XYLOGLUCAN-SPECIFIC ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844867" evidence="3">
        <location>
            <begin position="19"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW74780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="243" mass="25767" checksum="5AE5D15D88C2A788" modified="2014-03-19" version="1">MFLLTASFISSLAAAVTAQTITGAFDCLPAGTFTLCQNLWGRTAGVGSQNSTLISTSGNSISWSTNWTWVDAPNNVKSYANVESSSAKGVQLSAITTAPTTWTWTYETESSGIRADVSYDIWFGSASSGDPASAASSYEIMIWLSGLGGIQPVGSQITTGTQVAGHAWNLWKGPNANWEVLSFVSTDGNIQDFDADLNDFFQYLIDEQGVSSSQFVQAIQTGTEPFTGAANLVTSEYSVAINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4JP18</accession>
    <name>W4JP18_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_422965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552677.1">
        <property type="nucleotide sequence ID" value="XM_009554382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JP18"/>
    <dbReference type="FunCoup" id="W4JP18">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="GeneID" id="20673858"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_422965"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_0_0_1"/>
    <dbReference type="InParanoid" id="W4JP18"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="370" mass="40867" checksum="A1EBC625792DF572" modified="2014-03-19" version="1">MSVQSKLFETIRVGKCDLKHRVVMAPLTRLRHSATHVPGPGAAEYYAQRASTPGTLVVTESTVIAPQAGGFEYGLNTPGIWSDEQISEWKKVVEAVHAKGSFIFVQLWAMGRAASPSILALDGPELPYVGASDIPLRGRDHEPPAALTIPEIKEYAQLHATAAINAVHKAGFDGVEINCAMGFLLDQFLQDVSNNRTDEYGGSIENRIRFPLEMIGAVVDAVGADRVGLKLSPWNSFQDMRMADPVPTFSALVTRIRDVHPEFAYINVKEARIEGTSERPTTAEENNEFLRKIWGARPYLASGGYNREDAIKTADEKGGLIVFGRWFISNPDLPVRLKKNIPLSPYDPNTFYTPDNVKGYTDYPFSGEDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4JP60</accession>
    <name>W4JP60_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 monooxygenase 67</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cyp67</name>
        <name evidence="11" type="ORF">HETIRDRAFT_56910</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553048.1">
        <property type="nucleotide sequence ID" value="XM_009554753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JP60"/>
    <dbReference type="STRING" id="747525.W4JP60"/>
    <dbReference type="GeneID" id="20678376"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_56910"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_3_1"/>
    <dbReference type="InParanoid" id="W4JP60"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYTOCHROME_P450"/>
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    </dbReference>
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    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW74676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="518" mass="58534" checksum="93C6C7ABDD617E3F" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPK9</accession>
    <name>W4JPK9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_482211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552887.1">
        <property type="nucleotide sequence ID" value="XM_009554592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPK9"/>
    <dbReference type="GeneID" id="20678017"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_482211"/>
    <dbReference type="HOGENOM" id="CLU_621215_0_0_1"/>
    <dbReference type="InParanoid" id="W4JPK9"/>
    <dbReference type="OrthoDB" id="2269034at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004843989" description="F-box domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="48095" checksum="C2CFC8D55F4A9B9E" modified="2014-03-19" version="1">MGKTKAFPAEVLSLIFLHCTPPESHAVHPSTAPLVLTKVARRWRHVARSTPCLWSALTLPDAPRDPAALEAFFDALASWLALSRSTLLSIVLATSDTRADVLLRYLGILFPHSQRFRALRIEVAHDLDVLPSVPHDALPVVQDLDVSSLVVLLDSLILPRLRSLRLSSFLMPGDIHLHLALRRLSTHCFASLHTLTLCEVPIEDGRLSEGLEGLAALVSLALDQMYIGTRFCAALSYVFAPDGTLVAGQNTRLAHMYLNCGAATDLAAYHTALADMVVSRCCVPPGARAARLEAFCLPGGYAPRLRVSGTKRKQGAPKQEARIHRCCKDSGLVYRTKCLTSCECESRALIPLVRDVDGSLTLASRVQSSRGHRDLNSGPIVPLPVKSRDVDILTYVNRFSYYSHKCLSCISPHTYNIASIGIIVSLAVSILIRTCSTNSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQD5</accession>
    <name>W4JQD5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_481257</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552028.1">
        <property type="nucleotide sequence ID" value="XM_009553733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQD5"/>
    <dbReference type="STRING" id="747525.W4JQD5"/>
    <dbReference type="GeneID" id="20677965"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_481257"/>
    <dbReference type="eggNOG" id="KOG2069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017968_2_0_1"/>
    <dbReference type="InParanoid" id="W4JQD5"/>
    <dbReference type="OrthoDB" id="1661054at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007255">
        <property type="entry name" value="COG8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04124">
        <property type="entry name" value="Dor1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW75772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="552" mass="59419" checksum="8AA9FB1A8FE8F247" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQE4</accession>
    <name>W4JQE4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eisosome component PIL1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_461191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552558.1">
        <property type="nucleotide sequence ID" value="XM_009554263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQE4"/>
    <dbReference type="GeneID" id="20677149"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_461191"/>
    <dbReference type="eggNOG" id="ENOG502QQ1T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012875_0_0_1"/>
    <dbReference type="InParanoid" id="W4JQE4"/>
    <dbReference type="OrthoDB" id="5599269at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
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            <end position="781"/>
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    </feature>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW75106.1"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
    <sequence length="831" mass="88508" checksum="530BCA8D90446958" modified="2014-03-19" version="1"> </sequence>
</entry>
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                <person name="Bouzid O."/>
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                <person name="James T.Y."/>
                <person name="Karlsson M."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Lucas S."/>
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                <person name="Velez H."/>
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                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
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</entry>
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    <accession>W4JRW7</accession>
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            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
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                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="188"/>
        </location>
    </feature>
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            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="188" mass="20507" checksum="792175F28F566C1D" modified="2014-03-19" version="1">MKVRRRPSWRQSFPTHVYILTSSFPPAPPPTCLPSTLVRSAHAPHVSGRASLRPHIRTLISVNTSTPTTQCPRNHSARLSAQPDEAAIPPPISPAHIRPLQRTHHLGSKSLSTLPLDLLGHQSSRLCPHAQALTRVPSTPRKVASSFSLPRPASPLRPRGPTTVGVPTLSPSLHRVDEEVKEQLVAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4JS06</accession>
    <name>W4JS06_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 monooxygenase 45</fullName>
        </submittedName>
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        <name evidence="11" type="primary">cyp45</name>
        <name evidence="11" type="ORF">HETIRDRAFT_148210</name>
    </gene>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
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                <person name="Park J."/>
                <person name="Raffaello T."/>
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                <person name="Yakovlev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
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        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="747525.W4JS06"/>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_148210"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_3_1"/>
    <dbReference type="InParanoid" id="W4JS06"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW75666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="517" mass="58268" checksum="442017A5DB5A5995" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4JS40</accession>
    <name>W4JS40_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_429843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551273.1">
        <property type="nucleotide sequence ID" value="XM_009552978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JS40"/>
    <dbReference type="STRING" id="747525.W4JS40"/>
    <dbReference type="GeneID" id="20674385"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_429843"/>
    <dbReference type="eggNOG" id="ENOG502RCZD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101366_0_0_1"/>
    <dbReference type="InParanoid" id="W4JS40"/>
    <dbReference type="OrthoDB" id="3227035at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="22617" checksum="2CBD91212D84D030" modified="2014-03-19" version="1">MSSKELKFAVSGSIVAKSTQLSQTRELLVGGKTYVDAEPGTLHWFSFEIEAKAGEPARFGVFNGFATEADRDVHQAGGLARAAAANGDALFEGPAVIEKVDLLASKVTPDAKAGIKFGVRVKLTAKPEHAGDVKAALLRLEQDVAREAGTPYWYAVAWPGTSTFGVFSVFYDEGSRQAYMLGSAVKKFIAATEGSVTSAAEIDVLEVLATKIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JS50</accession>
    <name>W4JS50_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_422382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551974.1">
        <property type="nucleotide sequence ID" value="XM_009553679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JS50"/>
    <dbReference type="GeneID" id="20673806"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_422382"/>
    <dbReference type="HOGENOM" id="CLU_1547784_0_0_1"/>
    <dbReference type="InParanoid" id="W4JS50"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="183" mass="18729" checksum="35ACF4324681C1E9" modified="2014-03-19" version="1">MGGTIATVSHTAALRTGPLHEIARQSDPASIGTRSTGHLVASLAISARSAHAVPVWDRDSMRPPHTSQPSVGPVILSAIDAHNIQAGTTLGQDPAASAGPVMPSATYARETEAGTLFGQGPEASAGPVMPSAADPHGTEASASFSQDPAALPVNDVDPDSRRVLPLPAISVRKDIPPYVMQHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTK4</accession>
    <name>W4JTK4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">MFS sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_37838</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551152.1">
        <property type="nucleotide sequence ID" value="XM_009552857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTK4"/>
    <dbReference type="GeneID" id="20671923"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_37838"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="InParanoid" id="W4JTK4"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF23">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="14"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW76863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="520" mass="56960" checksum="1F90DE1129CC6D2B" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTZ9</accession>
    <name>W4JTZ9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_174965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551789.1">
        <property type="nucleotide sequence ID" value="XM_009553494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTZ9"/>
    <dbReference type="GeneID" id="20668545"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_174965"/>
    <dbReference type="HOGENOM" id="CLU_2441135_0_0_1"/>
    <dbReference type="InParanoid" id="W4JTZ9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="90" mass="9868" checksum="6187BEEA6A55A738" modified="2014-03-19" version="1">MTSGKALWPTKCPLSACASSLLYPSIFTHTRYPIRRDCSDPALCCGLSHMVSYLPSSLTQSDSRARQRVIWPRSTETSGGLTLSTVHSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUB0</accession>
    <name>W4JUB0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_326740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550681.1">
        <property type="nucleotide sequence ID" value="XM_009552386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUB0"/>
    <dbReference type="GeneID" id="20671268"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_326740"/>
    <dbReference type="eggNOG" id="ENOG502STHT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1713518_0_0_1"/>
    <dbReference type="InParanoid" id="W4JUB0"/>
    <dbReference type="OrthoDB" id="3070403at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW77137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="153" mass="17453" checksum="5C100D2317A82F05" modified="2014-03-19" version="1">MEKIEDEVGVFSKQFKLVFSWQTRSTGDGIILIVEHGQAICAVVDVLWEYHDRYPSNEVIMKWGRDVLRGVRQIYAKKGLDYPLVSMDPKPNTSKRKRSAFMESAGTEVKVVASSRSDFLGRTPDPPKMVSNISEWIDMSLFIVKRCLPRSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUQ4</accession>
    <name>W4JUQ4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_389839</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="5"/>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551665.1">
        <property type="nucleotide sequence ID" value="XM_009553370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUQ4"/>
    <dbReference type="GeneID" id="20672425"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_389839"/>
    <dbReference type="eggNOG" id="ENOG502SEDF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065200_6_2_1"/>
    <dbReference type="InParanoid" id="W4JUQ4"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW76795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="194" mass="21472" checksum="180D3E9D3B781915" modified="2014-03-19" version="1">MYTHSVLEVLAIVCVNTSTSPHASTEVKALAQRVLSLLCAIPARSAHSASALQITPSFLLGFALVALSAYIRTLCYRTLGRLFTFEISIQPKHKLVTSGPYSIVRHPSYTGSIIGFAGSLVCAFCAGGWFCECGWLDTAVGKLFVVAYVLWNVQFASVMLWRTGQEDQMMHGKFGKEWEGWREKVRYKIIPGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUZ6</accession>
    <name>W4JUZ6_HETIT</name>
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        <submittedName>
            <fullName evidence="7">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_174003</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550874.1">
        <property type="nucleotide sequence ID" value="XM_009552579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUZ6"/>
    <dbReference type="STRING" id="747525.W4JUZ6"/>
    <dbReference type="GeneID" id="20668482"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_174003"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_3_1"/>
    <dbReference type="InParanoid" id="W4JUZ6"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW77357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="315" mass="34656" checksum="9D14906C3254B63F" modified="2014-03-19" version="1">MTGTLPGAIGGLLAFGLVRAHTSVLKGWQFLFLVEAIPDLIMAVMILLFLPSFPFSSTFLNARERAIAQARLDRDHKPQSHGGMTGWQGFKAIVTDLNAWLLMMVYATFNIGVATVSYFLPTLIRELGFTSIQAQGMTVAPYLVGWFMVFFQAWHSDRTSDRGWHVMASTFVSFVGYLILATSVQKSVGAAYFALFLVVGGNYSLFPLVMSWAANTFSPTSKRGVGTAFIVSISNCVSIASPQIYFDPEDSYRKGHAISAACLLVSFTCAFILRTRLSRKNKENAEKLAVLEAEGELEPPSGELADHDPRYVFMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWN6</accession>
    <name>W4JWN6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_326147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549883.1">
        <property type="nucleotide sequence ID" value="XM_009551588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWN6"/>
    <dbReference type="GeneID" id="20671212"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_326147"/>
    <dbReference type="HOGENOM" id="CLU_2455005_0_0_1"/>
    <dbReference type="InParanoid" id="W4JWN6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW77864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="89" mass="9791" checksum="AD55D6408BCD9D3C" modified="2014-03-19" version="1">MGAYRGFCAVGILLEADGWAMSDAVARRKSNDWNAHGQHKAHIGSIRLEYHVRLYFQTRPHPLPSFRSATLCTLPGSARRGTAPLCVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWN7</accession>
    <name>W4JWN7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">GST9</name>
        <name evidence="2" type="ORF">HETIRDRAFT_107605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549991.1">
        <property type="nucleotide sequence ID" value="XM_009551696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWN7"/>
    <dbReference type="STRING" id="747525.W4JWN7"/>
    <dbReference type="GeneID" id="20666260"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_107605"/>
    <dbReference type="eggNOG" id="KOG2903">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037263_0_1_1"/>
    <dbReference type="InParanoid" id="W4JWN7"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="1">
        <location>
            <begin position="95"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="257" mass="29597" checksum="C993F7D97E6DD993" modified="2014-03-19" version="1">MRKLKSLESIISVTIASPHQYEKGYAFASVDDFPGSEVDPLYDSSYIEDLYLRADPDYTGKCTVPVLWDKILHTIVNNDASDIMRIFNFAFNGLLPENKAALDFYPAHISPEIDDFSEWADGVMIEGAHKTGLATTFEKYRCVVVPLFEALDRVERMLKDKTYLIGDRLTAADISLYTTLIRFDPVYVDLFKCNLKTIRHGYPNIHLWLRRLYWCNDAFQSTTDFNHIKIGYYSSWMEINPHCIVPIGPVPHIEPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXP9</accession>
    <name>W4JXP9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Small nuclear ribonucleoprotein Sm D1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">snRNP core protein D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_441580</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550236.1">
        <property type="nucleotide sequence ID" value="XM_009551941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXP9"/>
    <dbReference type="FunCoup" id="W4JXP9">
        <property type="interactions" value="608"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JXP9"/>
    <dbReference type="GeneID" id="20675375"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_441580"/>
    <dbReference type="eggNOG" id="KOG3428">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123956_3_0_1"/>
    <dbReference type="InParanoid" id="W4JXP9"/>
    <dbReference type="OrthoDB" id="9626941at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097525">
        <property type="term" value="C:spliceosomal snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01724">
        <property type="entry name" value="Sm_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000016">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034102">
        <property type="entry name" value="Sm_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="79"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW78249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="122" mass="13534" checksum="E8641DB01D644204" modified="2014-03-19" version="1">MKLVRFLMKLNNETVTIELKNGCVVHGTITGVDMQMNTHLKTVKMTARNRDPTSLDSLSIRGNNIRYFILPDSLPLDTLLVDDAPKPKGRKKEDTRGRGRGGRGGGDRGRSRGRGRGRGRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXU8</accession>
    <name>W4JXU8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Rab-type small GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_325373</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Protein transport. Probably involved in vesicular traffic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550336.1">
        <property type="nucleotide sequence ID" value="XM_009552041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXU8"/>
    <dbReference type="FunCoup" id="W4JXU8">
        <property type="interactions" value="385"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JXU8"/>
    <dbReference type="GeneID" id="20671145"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_325373"/>
    <dbReference type="eggNOG" id="KOG0078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_23_1_1"/>
    <dbReference type="InParanoid" id="W4JXU8"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000363">
        <property type="entry name" value="Secretion related GTPase srgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW78358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="23017" checksum="A9098BA358DA98CD" modified="2014-03-19" version="1">MPPPHYDFLIKLLLIGDSGVGKSCLLLRFCDDAWTPSFITTIGIDFKIRTIELDGKRIKLQIWDTAGQERFRTITTAYYRGAMGILLVYDVTDERSFNNIRTWHANIEQHASEGVNKILIGNKSDWTDKKAVTEEQGRALADELGIRFMETSAKVNEGVEEAFFTLARDIKARLIDSQADAAGAPGGSPADGSVKVNQPSTQTATGCCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXX7</accession>
    <name>W4JXX7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_68379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549690.1">
        <property type="nucleotide sequence ID" value="XM_009551395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXX7"/>
    <dbReference type="STRING" id="747525.W4JXX7"/>
    <dbReference type="GeneID" id="20678857"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_68379"/>
    <dbReference type="eggNOG" id="ENOG502S9XI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025711_4_3_1"/>
    <dbReference type="InParanoid" id="W4JXX7"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="7"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW78388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="218" mass="23508" checksum="1C20C7DDE73EA9D2" modified="2014-03-19" version="1">MRVLILGATGPTGILIVRELLASSVQYDIVIYARTPTKLPSDIVTHQDVAIIKGELSDSDTFSKAVEGVEAVLSALGPLASHPNNNPLAHGYKLLLELMQRHSVTRLIALGTASITDENDKSSWAYSAMIATVKLLARNAYNDIVAVGEVIKASPENLRWTIVRVGLLTNAENNDVIVGYVGDGKTGTRLARAGYATFALQELEKERWSRKAPLISSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4JY17</accession>
    <name>W4JY17_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_479161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549997.1">
        <property type="nucleotide sequence ID" value="XM_009551702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JY17"/>
    <dbReference type="STRING" id="747525.W4JY17"/>
    <dbReference type="GeneID" id="20677856"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_479161"/>
    <dbReference type="eggNOG" id="KOG4265">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015598_0_0_1"/>
    <dbReference type="InParanoid" id="W4JY17"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045194">
        <property type="entry name" value="MGRN1/RNF157-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996">
        <property type="entry name" value="MAHOGUNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996:SF0">
        <property type="entry name" value="RE60872P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="372"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="531"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW77990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="574" mass="61224" checksum="D0887D76C6282E1D" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYV4</accession>
    <name>W4JYV4_HETIT</name>
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        <recommendedName>
            <fullName evidence="4">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="5" type="ORF">HETIRDRAFT_388136</name>
    </gene>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550054.1">
        <property type="nucleotide sequence ID" value="XM_009551759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYV4"/>
    <dbReference type="FunCoup" id="W4JYV4">
        <property type="interactions" value="521"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JYV4"/>
    <dbReference type="GeneID" id="20672352"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_388136"/>
    <dbReference type="eggNOG" id="KOG2050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013994_2_0_1"/>
    <dbReference type="InParanoid" id="W4JYV4"/>
    <dbReference type="OrthoDB" id="497380at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012959">
        <property type="entry name" value="CPL_dom"/>
    </dbReference>
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        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040059">
        <property type="entry name" value="PUM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389:SF0">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="81"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW78051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="618" mass="69473" checksum="5BD6E4F7BA573B86" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYY9</accession>
    <name>W4JYY9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_107862</name>
    </gene>
    <organism evidence="1 2">
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYY9"/>
    <dbReference type="GeneID" id="20666285"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_107862"/>
    <dbReference type="eggNOG" id="ENOG502S3G3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158785_0_0_1"/>
    <dbReference type="InParanoid" id="W4JYY9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="124" mass="14060" checksum="C449C0F556C5F88F" modified="2014-03-19" version="1">MPLAKNGNMMASLQAPVTIAEKQDTGILTARHDAEAFNRLEETRRDAWVRQGEEAARLIWKEKTTHPLWETNGYHNLVLQWNVLTLPHPDDPERTMGNALCYLTDDGETEASVILLESEQCSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZ47</accession>
    <name>W4JZ47_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_147314</name>
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    <organism evidence="10 11">
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009550815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZ47"/>
    <dbReference type="FunCoup" id="W4JZ47">
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    </dbReference>
    <dbReference type="GeneID" id="20667193"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_147314"/>
    <dbReference type="eggNOG" id="KOG1286">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="InParanoid" id="W4JZ47"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="56"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW78807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="554" mass="60727" checksum="116A3027E0C98316" modified="2014-03-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZH6</accession>
    <name>W4JZH6_HETIT</name>
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        <recommendedName>
            <fullName evidence="8">Splicing factor U2AF subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">U2 snRNP auxiliary factor large subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_36024</name>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for the splicing of pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the splicing factor SR family.</text>
    </comment>
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        <property type="protein sequence ID" value="ETW78983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548742.1">
        <property type="nucleotide sequence ID" value="XM_009550447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZH6"/>
    <dbReference type="FunCoup" id="W4JZH6">
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    </dbReference>
    <dbReference type="STRING" id="747525.W4JZH6"/>
    <dbReference type="GeneID" id="20671811"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_36024"/>
    <dbReference type="eggNOG" id="KOG0120">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021795_4_2_1"/>
    <dbReference type="InParanoid" id="W4JZH6"/>
    <dbReference type="OrthoDB" id="10266058at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="RRM1_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12231">
        <property type="entry name" value="RRM2_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
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    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
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    </dbReference>
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        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006529">
        <property type="entry name" value="U2AF_lg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01642">
        <property type="entry name" value="U2AF_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="115"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="224"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="338"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW78983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="460" mass="49185" checksum="A8C92B0D3B2FE24D" modified="2014-03-19" version="1">MPRGGGPGAGGRRGRRAERDGGPGAGTPERRSPTPPGVIPLSQRRRKASGWDVHAPGYEQYSAMQAKQTGLFNLPGANRTQIPPILSVPGLPPPMPVQTFGMGMGVNPNLSRQSRRLYIGSITSDINEQNLADFFNNKMIEMNIGTGAPGNPVLAVQCNYEKNYAFVEFRSAEDATAAMAFDGIIFLNGPLKIRRPKDYGGIDMSAPAYIVPGVVSTNVPDSANKIFVGGLPSYLNEEQVMELLKSFGELRAFNLVRENGNGASKGFAFFEYNDPSVTDVAIQSLSGMELGDRYLVVQRASVGAKAGQPGIPNLPYDQFPEIPRPILPAGDLSTSDARILLMLNMVTPDDLVDDQEYADILDDIREEVGNYGTVEDVRIPRPGAGIGDAQRADEASGVGRVYVKYTDSNGAAAAMKALAGRAFAGRSIIATVLSEDSQTTPPLELIFAPQPHAPPPLPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4K033</accession>
    <name>W4K033_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_454397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550428.1">
        <property type="nucleotide sequence ID" value="XM_009552133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K033"/>
    <dbReference type="GeneID" id="20676504"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_454397"/>
    <dbReference type="HOGENOM" id="CLU_1816052_0_0_1"/>
    <dbReference type="InParanoid" id="W4K033"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="142" mass="15316" checksum="2980C9E0DF4ADA1E" modified="2014-03-19" version="1">MPPCATSRHTGGSTRFSAHRQPTHNFPAALPPSTHSCAQPPSKPERAQRQPPPFARQMADAARCLGRERTPRYERVLRVHRRTCRRVSSPRPSATAGLSWLAMRACMGSPLPGRAPAQQAALGVAGVFASEWIIVCAAGSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0K8</accession>
    <name>W4K0K8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="12">DHBP synthase</shortName>
            <ecNumber evidence="3 12">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_387644</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the DHBP synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="3 12"/>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549555.1">
        <property type="nucleotide sequence ID" value="XM_009551260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0K8"/>
    <dbReference type="FunCoup" id="W4K0K8">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K0K8"/>
    <dbReference type="GeneID" id="20672323"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_387644"/>
    <dbReference type="eggNOG" id="KOG1284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020273_3_0_1"/>
    <dbReference type="InParanoid" id="W4K0K8"/>
    <dbReference type="OrthoDB" id="60371at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000002">
        <property type="entry name" value="3,4-dihydroxy-2-butanone 4-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00180">
        <property type="entry name" value="RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF18">
        <property type="entry name" value="3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0318">Glutathionylation</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW79312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="249" mass="27261" checksum="E9357A03E9CCF601" modified="2014-03-19" version="1">MASAATASTSEPAELVSVNHWHPKSRDVPPRTAFAFDPIEDALEAFARGEFLVVMDDESRENEGDLIVAASGCSTEQMAWMIKHTSGYICIALPGERLEELQIPMMVPQNEERHRTAYTVTVDYKHGTTTGISAHDRALTARALALPSSTPADFTRPGHLVPLRARTGGVLTRRGHTEASVDLCRLAGLAPAGLLCEIVNDDEQGSMSRRDECRAFADRWGVKMINVGMLVDWRRKLGPALQNGHVEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0N3</accession>
    <name>W4K0N3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_453780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549585.1">
        <property type="nucleotide sequence ID" value="XM_009551290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0N3"/>
    <dbReference type="GeneID" id="20676421"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_453780"/>
    <dbReference type="HOGENOM" id="CLU_1896488_0_0_1"/>
    <dbReference type="InParanoid" id="W4K0N3"/>
    <dbReference type="OrthoDB" id="391988at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="134" mass="15093" checksum="A5524E33A4A0389B" modified="2014-03-19" version="1">MSQNQTRFEQELKSTVDEILQTCPKRADSYVRCRILNYTLEVVEHGRTAVVSDIEDETTSPQDPRLILHDSQGSSHGDAGTLELVLNFIYKRSRMTDIKDKLHAIRLCTAVPTYGGSLLEIADEMIIQLKARGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4K161</accession>
    <name>W4K161_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_410302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548046.1">
        <property type="nucleotide sequence ID" value="XM_009549751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K161"/>
    <dbReference type="GeneID" id="20672854"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_410302"/>
    <dbReference type="HOGENOM" id="CLU_2638356_0_0_1"/>
    <dbReference type="InParanoid" id="W4K161"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="77" mass="8236" checksum="BA573F229BC4E447" modified="2014-03-19" version="1">MQGLDLRLSSSLDLPRQNCRPCTFSLAHGLAATAPIVGLLLQEKSLRGGQIPDADCRSSTVPANESARSVWSINSWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1B0</accession>
    <name>W4K1B0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_117243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548186.1">
        <property type="nucleotide sequence ID" value="XM_009549891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1B0"/>
    <dbReference type="GeneID" id="20666544"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_117243"/>
    <dbReference type="HOGENOM" id="CLU_444846_0_0_1"/>
    <dbReference type="InParanoid" id="W4K1B0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="614" mass="64365" checksum="17347E6A87B4A185" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1S8</accession>
    <name>W4K1S8_HETIT</name>
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        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_445822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009551032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1S8"/>
    <dbReference type="STRING" id="747525.W4K1S8"/>
    <dbReference type="GeneID" id="20675648"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_445822"/>
    <dbReference type="eggNOG" id="ENOG502T9DQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1158761_0_0_1"/>
    <dbReference type="InParanoid" id="W4K1S8"/>
    <dbReference type="OrthoDB" id="3364132at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR EAF N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="7"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW79056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="240" mass="27133" checksum="FA117BC1988B88B9" modified="2014-03-19" version="1" fragment="single">MPQLHGYSVTITSHGREVEHYDVKLENPDTVSCYIVSESGMEFTVQYTDLQGRRTMKVDVFIDGRMLASKSAEPGKTLSIWGSRTSKTTRSTFRFSEITLVDDDDADGLVTPPSIGSIEVKLYRARIEKCRISSRSHYRRSDPPQTGPVSEKSKKGGWHQVSLGRDRRSEWQPSPTRAIRLDPIDAPYAIFRFNYRPRAMLQAENIIPPLGMLTKLNVEALQAPVCKRSPSPHIARNLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1Z6</accession>
    <name>W4K1Z6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_117862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549595.1">
        <property type="nucleotide sequence ID" value="XM_009551300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1Z6"/>
    <dbReference type="STRING" id="747525.W4K1Z6"/>
    <dbReference type="GeneID" id="20666566"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_117862"/>
    <dbReference type="HOGENOM" id="CLU_580105_0_0_1"/>
    <dbReference type="InParanoid" id="W4K1Z6"/>
    <dbReference type="OrthoDB" id="3362851at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="471" mass="50931" checksum="303BCD817BB21691" modified="2014-03-19" version="1">MDPPWSPSSGKRPRKRKARSPSPEQPPHSPKRASGSQLSATVLPPIREMQAFLPSPGPPSQHPEDVYPQHPQPTGFPLFSSSDSRFVSQAGPSTPAAEYNPEIMDSEPEADAEPSGRPKQKRRRQALSCTERTHVDHVLGVLTIIVGSPVKSFSDKYVSRAEFDEVKARLDKLEAIVYGTPPAALPPSSSIELSSRSATIGVGMPSAASSSRRYTEPHHQIPPFPTGPSRREDYPSKHTSSEHSNPASVHVTAPSQTAHPAPSQPHSQTYLGQPSSQSSPTFRSYESTRSPSHHFGGSGVGGDTGPGAVSIAGPSSAVKPSPFSLSAITAPYNTPVAPPLPQPHPKNSYAQTFTPLGERLCIRVVQGPAAPTYPHLSHIVDSLSRSFTPTRAPTFRPCSCSHRRRCYRPRPARCQRPMITMGELIVRAARGRYHGGSAMRAHTRSHRNLMLIAAKGTLQTSERRLHAPGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4K276</accession>
    <name>W4K276_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_452898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548364.1">
        <property type="nucleotide sequence ID" value="XM_009550069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K276"/>
    <dbReference type="GeneID" id="20676309"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_452898"/>
    <dbReference type="HOGENOM" id="CLU_1195010_0_0_1"/>
    <dbReference type="InParanoid" id="W4K276"/>
    <dbReference type="OrthoDB" id="5401486at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="232" mass="25305" checksum="3F9B162B499A60E3" modified="2014-03-19" version="1">MQFHWKQVPRSEKKETKDREWVALSEHRLTRSDTGLVARKWSPTVTISPLLHDEESSTSSFRCLAKHGGVADDGLVQGHRQQRPATTNKTHRLQISLPTNTATSSTSVDFPAAVDVSQVRLPSLLGASISASTPEASFNADPLPDARTTDRLTAVHSRHQGPAAHQGPAAHQGPAAHQSPAGQSVHTPSTRTPTGTHALRLEDEQQKNTGTHALRLEDEQQKNTRTTTTPWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4K281</accession>
    <name>W4K281_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DEAD/DEAH-box helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_232841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548459.1">
        <property type="nucleotide sequence ID" value="XM_009550164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K281"/>
    <dbReference type="GeneID" id="20668721"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_232841"/>
    <dbReference type="eggNOG" id="KOG0351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001103_20_0_1"/>
    <dbReference type="InParanoid" id="W4K281"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD/DEAH-box helicase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="129" mass="14460" checksum="555AE0DCE65A4510" modified="2014-03-19" version="1" fragment="single">LSQIYKKTLSFFKKHPCLWQLKVVKAILKGDRDVTCISGTGSGKTLTFWMPLLFASRIQIIVTPLNILGKQNEGDLRKLGIPAVTLTGQTSNPAIYQYCAIIVSSEELIKENGGFEKLWKNEQFTSQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2F0</accession>
    <name>W4K2F0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_435197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548507.1">
        <property type="nucleotide sequence ID" value="XM_009550212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2F0"/>
    <dbReference type="FunCoup" id="W4K2F0">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K2F0"/>
    <dbReference type="GeneID" id="20674808"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_435197"/>
    <dbReference type="eggNOG" id="KOG1203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025711_1_3_1"/>
    <dbReference type="InParanoid" id="W4K2F0"/>
    <dbReference type="OrthoDB" id="10254604at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF50">
        <property type="entry name" value="UPF0659 PROTEIN YMR090W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="10"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="246" mass="26057" checksum="D8FD88263526C289" modified="2014-03-19" version="1">MSLKKVVIVGGHGKVALRLAGLIASKHSITSIIRDPAHSADLKAISTDITPLVLSLEDSPVSEFSSAFTDAATVVFSAGAGGNGGAERTRKVDYEGALKVFDAIEAVAGPKPHLVLVSALDVRDPNKIPEHYTEEDKNVSERVRSRIKDYMHWKYEADKNLVARTAFTWTILRPGGLTEGPGTGKASIGRTHMIPTIPRGDVANALAALVDRPDAAGLAIDIVGGETLISEGIDAFIKKGVTDWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2M7</accession>
    <name>W4K2M7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_445928</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549551.1">
        <property type="nucleotide sequence ID" value="XM_009551256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2M7"/>
    <dbReference type="FunCoup" id="W4K2M7">
        <property type="interactions" value="493"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K2M7"/>
    <dbReference type="GeneID" id="20675657"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_445928"/>
    <dbReference type="eggNOG" id="KOG1745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078295_4_0_1"/>
    <dbReference type="InParanoid" id="W4K2M7"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000001">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HISTONEH3"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="47"/>
            <end position="134"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="22"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW79306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
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</entry>
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    <accession>W4K3B7</accession>
    <name>W4K3B7_HETIT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
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                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_418330"/>
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    <dbReference type="InParanoid" id="W4K3B7"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="81" mass="9242" checksum="DD15EBCDCCC7D2F0" modified="2014-03-19" version="1">MYIVSYIELDSILCLLDVHQPSYALIYRDTISDAMSIDPGSRVPVRELACTGFFSDFDDPRHPAIQKHPCKQYRPQPPTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3D0</accession>
    <name>W4K3D0_HETIT</name>
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        <recommendedName>
            <fullName evidence="8">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_35628</name>
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    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009549620.1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="eggNOG" id="KOG2248">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
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        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW79586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="649" mass="71644" checksum="F0F506B6CECFA5F7" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3N8</accession>
    <name>W4K3N8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_241243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547106.1">
        <property type="nucleotide sequence ID" value="XM_009548811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3N8"/>
    <dbReference type="GeneID" id="20668887"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_241243"/>
    <dbReference type="HOGENOM" id="CLU_046025_16_0_1"/>
    <dbReference type="InParanoid" id="W4K3N8"/>
    <dbReference type="OrthoDB" id="2884999at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="209" mass="23513" checksum="F9782658009EA0EE" modified="2014-03-19" version="1" fragment="single">MPGIDTSLGASLNCAFISCFLYGAMAIQTYTYYQSGFNTTDSLMIRILVFITRFSETATTILVCIYAYSCAVSNFGDPNYLTLTVWPLKYTLLGSLITALLVEVFFAWRIRTLSRTWLLTILSLTSCLLRLCGTVALMFVIPKDPVDIAGFVRNHRGLVIILFGTGVFSDFVNASALCYYLWRDNSVREARHSTQRVINKIIMWTIGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3Y7</accession>
    <name>W4K3Y7_HETIT</name>
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        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_320366</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547281.1">
        <property type="nucleotide sequence ID" value="XM_009548986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3Y7"/>
    <dbReference type="FunCoup" id="W4K3Y7">
        <property type="interactions" value="145"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K3Y7"/>
    <dbReference type="GeneID" id="20670660"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_320366"/>
    <dbReference type="eggNOG" id="KOG3750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048143_1_0_1"/>
    <dbReference type="InParanoid" id="W4K3Y7"/>
    <dbReference type="OrthoDB" id="5579088at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034389">
        <property type="term" value="P:lipid droplet organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019388">
        <property type="entry name" value="FIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10261">
        <property type="entry name" value="FIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844281" evidence="9">
        <location>
            <begin position="24"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW80548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="284" mass="31544" checksum="E905A05A8CF8AD8F" modified="2014-03-19" version="1">MTDLRVVALILSFLVVLIGTLHSVKNHTYLDTSNPLLTALPHPLHKTHYFASKSNPLNTVFIKRAWGWTSAVFILHIFTSPPRTHRARRTIQYLLATFTWLAFTTWFFGPALIDRFIVVSGGECVLHLPGPDGAYVPVDQEYCFTHARLSPSTHPDLFPPVPNASALLEKWAGVPRLRRGHDVSGHVFLLTLSTLFLADQVRASFRARTAWSQAHLLGVVFSVSLIMLWLFANWTTSVYYHSPVEKVSGFLLGVLGFAASQAPLLLFPEAVSSPAPIAAKLHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4K459</accession>
    <name>W4K459_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_101679</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547268.1">
        <property type="nucleotide sequence ID" value="XM_009548973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K459"/>
    <dbReference type="GeneID" id="20665789"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_101679"/>
    <dbReference type="HOGENOM" id="CLU_056208_0_0_1"/>
    <dbReference type="InParanoid" id="W4K459"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW80534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="408" mass="45995" checksum="3E5839D5B9586A3C" modified="2014-03-19" version="1">MAATTAGIMDIIEFEDEMTALQETARRHQEEADGRAAALFGQDAITGDGTPAETSLRTPSNSLFPLFLGDLQTPNSRDTFEPFHPDVNGCPGSLLLLGHAASEATVGTTSNISLINLATQPLTPCTKRHYKEYAEFCCEEADIPKSKHAHIVEAAQRPLQELMIKVLVAVNAPMSEEEGLSALQTFIVSDDTLEEFIKAPVDIIMLDPKLSGFKLGFTSRLLHHIRVNPGQYHIPHRLIPFLTTKVFATAISRSIIASRAEIKRKLKELFHKKANIYALVKKLVGNLKSQVTVTEDHWYRWAWVHNAYIRFENLNLHQKTFWNWVDNDLSLRRQSVKNMPEPARSKALKGMFKQAFDKHLNAYPPSKRLTASTQRETLWQTNAAHSISAMEEYDLHDIPNDVDEEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4K486</accession>
    <name>W4K486_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_322849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548393.1">
        <property type="nucleotide sequence ID" value="XM_009550098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K486"/>
    <dbReference type="GeneID" id="20670914"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_322849"/>
    <dbReference type="HOGENOM" id="CLU_1772493_0_0_1"/>
    <dbReference type="InParanoid" id="W4K486"/>
    <dbReference type="OrthoDB" id="3242409at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="173" mass="19332" checksum="B66215DEB5009598" modified="2014-03-19" version="1">MGAFSCDRWYKIIGAISVIGRAAVITVFTMRTYTVCAQNRLILYVLGAIGLTCVVLDCLHVPGLRCQLSSSIKIGRESHRLSALPSFCSTTRQTANTLLSILICVLESVAAIFTVIRSFQANRVRGKGKLRNHTLHYLLLEQGVLYFWWISRHIRVSLYDELGILIAAYLSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4K565</accession>
    <name>W4K565_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 10">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 10">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GS2</name>
        <name evidence="12" type="ORF">HETIRDRAFT_61613</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 10"/>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546962.1">
        <property type="nucleotide sequence ID" value="XM_009548667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K565"/>
    <dbReference type="FunCoup" id="W4K565">
        <property type="interactions" value="232"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K565"/>
    <dbReference type="GeneID" id="20678564"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_61613"/>
    <dbReference type="eggNOG" id="KOG3754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010467_0_0_1"/>
    <dbReference type="InParanoid" id="W4K565"/>
    <dbReference type="OrthoDB" id="7939818at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000002">
        <property type="entry name" value="Glutamate--cysteine ligase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000001">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW80510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="683" mass="77720" checksum="E09EAC8E8F87CF0A" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5S5</accession>
    <name>W4K5S5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_319572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547421.1">
        <property type="nucleotide sequence ID" value="XM_009549126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5S5"/>
    <dbReference type="GeneID" id="20670611"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_319572"/>
    <dbReference type="HOGENOM" id="CLU_3143257_0_0_1"/>
    <dbReference type="InParanoid" id="W4K5S5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW80705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="49" mass="5683" checksum="C4EE66637AA7CAAB" modified="2014-03-19" version="1">MIVIRSIESRSRTTVVPSSSKFLRQTPTRPKSVNETYYRIQSARRIALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6X6</accession>
    <name>W4K6X6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_101887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547491.1">
        <property type="nucleotide sequence ID" value="XM_009549196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6X6"/>
    <dbReference type="GeneID" id="20665806"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_101887"/>
    <dbReference type="HOGENOM" id="CLU_1816051_0_0_1"/>
    <dbReference type="InParanoid" id="W4K6X6"/>
    <dbReference type="OrthoDB" id="3260546at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW80786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="142" mass="15843" checksum="8E76F1E05DBAB0E6" modified="2014-03-19" version="1">MATQVMLTQRELLSLSAEVRSQVREATLAHRSPNKDASNVRTFYQDANLPYTIDDLKPPTRPTVSSFVNVLHQPKTPLPGVIIIFDMYETYLKNLQPGQEVECVIDPGSQVIAMLEGICNKLALIYDPEIVLNMQSANGKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4K704</accession>
    <name>W4K704_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-structural maintenance of chromosomes element 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_320513</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the SMC5-SMC6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NSE4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547517.1">
        <property type="nucleotide sequence ID" value="XM_009549222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K704"/>
    <dbReference type="FunCoup" id="W4K704">
        <property type="interactions" value="246"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K704"/>
    <dbReference type="GeneID" id="20670671"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_320513"/>
    <dbReference type="eggNOG" id="KOG2866">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041037_1_0_1"/>
    <dbReference type="InParanoid" id="W4K704"/>
    <dbReference type="OrthoDB" id="361242at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027786">
        <property type="entry name" value="Nse4/EID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014854">
        <property type="entry name" value="Nse4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029225">
        <property type="entry name" value="Nse4_Nse3-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15412">
        <property type="entry name" value="Nse4-Nse3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08743">
        <property type="entry name" value="Nse4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nse4/EID protein Nse3/MAGE-binding" evidence="10">
        <location>
            <begin position="77"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Non-structural maintenance of chromosome element 4 C-terminal" evidence="9">
        <location>
            <begin position="222"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW80816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="326" mass="37203" checksum="DE382B5FF4518D06" modified="2014-03-19" version="1">MPRSDNDTLRNGPAYDPDQDPEEKRAIRRNYRNLTKGEDGAALNLNDYTAQELVDKVQRADSLFYRAVAAPQEATLDSAFLVMASNMGATKARAMKSGSGAFDMDDFISKLITFMGGRRGDQLSDESEMDDDHAGHRLDWEKIGRKALAKSRRVPTIDFMLGPLEVEQKKRNVGKRAKLEKNKEDERKPQELQEDDIIRAENETTKNVIAIQTLLEGMGEAVNLFRFVVNPHDFAQSVENIFYLSFLIRDGVCALEIQENGEPMIFICEAPGDQDYQQGLRKQQMVMSFDMETWERAIEVFNIQEPIIPQRPKQQAQMSDGRKWVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7J8</accession>
    <name>W4K7J8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_452487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547726.1">
        <property type="nucleotide sequence ID" value="XM_009549431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7J8"/>
    <dbReference type="STRING" id="747525.W4K7J8"/>
    <dbReference type="GeneID" id="20676259"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_452487"/>
    <dbReference type="eggNOG" id="ENOG502RZXK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061244_1_1_1"/>
    <dbReference type="InParanoid" id="W4K7J8"/>
    <dbReference type="OrthoDB" id="2310204at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844055" evidence="1">
        <location>
            <begin position="20"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="226" mass="23202" checksum="26C76D1D4A444241" modified="2014-03-19" version="1">MARIAIWCFLAAQATATLASSGLNIKRAVSFFDPNAGGGSMLDSVGGDLGEPLNVIISGLSSAAVLTDDGFLNYARSIGFSIECFGIHLGAPQTANLGDGNGSLNQTIELRQDYGNSDVGTCLESLIGGNHFRMWRQNGPSANSGALFLAVSKEENVTEGHTIVPDGYNIGRDDLVSAAAGTTSFDGVSYTTVAENLTGLLAPGSTGVNHGIATDGTTKLLTVTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7S6</accession>
    <name>W4K7S6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_417928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546468.1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="334" mass="36818" checksum="CCF400F1FDF8485F" modified="2014-03-19" version="1">MPDKLLVETDPTLPLRPLLHPAEHIDCVDCASMSATGSSVPAVSSDFSPEIIQVIATVASQSAFFGIFVVIMLFSTYFLCCKGFETKANVMMLSVTTIMFATSTTYWAFTLTISVMSVQALYHPDKITLQEGEFIGGLYIAQMYLPMINYVLSDTVVAWRAWVLWQHNTRISIIPFVPLLGSLGTPRGGLFNRLAVYKVKGFKSQATDSLFAAWVLSLATNVAATILIACKAWRHRRMIKSYLAHGGLRRTQMEKIFALLIESGALYCVLWVLLITTRFSVVSAPECELIQDASVQIAVRQIICSSTESIPSSLLGYLPYSHCRPSDSSENGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
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                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="van Diepen L.T."/>
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                <person name="Karlsson M."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
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                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
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                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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    <dbReference type="InParanoid" id="W4K829"/>
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    </dbReference>
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            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
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            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="136" mass="15088" checksum="57E587493FE2250C" modified="2014-03-19" version="1">MAHASVHRVDLPESKPDRTRASTVVIKVQPPSTPPSYTTSTLLRAFDRAWPAPLRAALARKGPPPTTHAETKITSAFKHPYPAPRRKRRAAKFGVPPRRLGAPTFVRSLGRSIDDYTYSASFFFFFRVGRRSAAAS</sequence>
</entry>
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                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_434334"/>
    <dbReference type="HOGENOM" id="CLU_1796723_0_0_1"/>
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    <dbReference type="Proteomes" id="UP000030671">
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    </dbReference>
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            <begin position="20"/>
            <end position="58"/>
        </location>
    </feature>
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        <location>
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            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="144" mass="15214" checksum="B8EE0CA57C08C5DC" modified="2014-03-19" version="1">MQRDAFYAIPKPCHECDSNRVTKSVTARPQSAHLPSIASPRARPPSQTRPNAHTCPKGQVAVGNSVVATVRKGKARVAQLGRSSAKRGGAPWRATTFRPDKEGAPQRAGFEAKPTRPSVRGAPGGMTRPHGCAGCAARKPRSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAA8</accession>
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    <protein>
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            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
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            <dbReference type="PubMed" id="22463738"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545092.1">
        <property type="nucleotide sequence ID" value="XM_009546797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAA8"/>
    <dbReference type="STRING" id="747525.W4KAA8"/>
    <dbReference type="GeneID" id="20676054"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_450525"/>
    <dbReference type="eggNOG" id="KOG4412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_18_2_1"/>
    <dbReference type="InParanoid" id="W4KAA8"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="156"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW82767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="218" mass="23460" checksum="EFF94D99852A1104" modified="2014-03-19" version="1">MLRSLLSADPKLLNAEDVDGRTPLHWAASSGSLEITRYLIDQKADINKMDGSGWSALHIAVSAGNEEVAKELIGAGADVNQRTDKGLTPLHYAASKSRVDIGRFLISRGADINARDKANQHPLHRAATTGSTGFVNLLLHPPEGAPKTRLNTGDRLGNTPLHLAMESAHAESAALLIEAGADRTRTNTEDQTAEDLEGVGGQEQKRAREYLIERFGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAL1</accession>
    <name>W4KAL1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NOT2/NOT3/NOT5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_247300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546684.1">
        <property type="nucleotide sequence ID" value="XM_009548389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAL1"/>
    <dbReference type="FunCoup" id="W4KAL1">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KAL1"/>
    <dbReference type="GeneID" id="20669162"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_247300"/>
    <dbReference type="eggNOG" id="KOG2151">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033275_4_1_1"/>
    <dbReference type="InParanoid" id="W4KAL1"/>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="38"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW82126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="168" mass="18771" checksum="B981607CBA43824B" modified="2014-03-19" version="1" fragment="single">LLGLLAMIKNADLDQNLLGVGTDLGTMGLDMQHQGNLYSTFITPWADASAAHAVEPDFHLPACYNVQPPAPGPNKAAAFSDDTLFFMFYSAPRDALQEVAAQELYNRNWRYHKELRLWLTKESGTAQSQKVPNGEQGTYTFWDPEGWGKERKEMTVLYGDLEEKSQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAT8</accession>
    <name>W4KAT8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Aspartic peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HETIRDRAFT_148451</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545148.1">
        <property type="nucleotide sequence ID" value="XM_009546853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAT8"/>
    <dbReference type="FunCoup" id="W4KAT8">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="GeneID" id="20667273"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_148451"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_1_1_1"/>
    <dbReference type="InParanoid" id="W4KAT8"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000060">
        <property type="entry name" value="Aspartic-type endopeptidase ctsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF75">
        <property type="entry name" value="ENDOPEPTIDASE (CTSD), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845332" evidence="13">
        <location>
            <begin position="24"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="14">
        <location>
            <begin position="222"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="253"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETW82834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="543" mass="54905" checksum="85010554A5AD9984" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAY9</accession>
    <name>W4KAY9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_433697</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Yakovlev I."/>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545172.1">
        <property type="nucleotide sequence ID" value="XM_009546877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KC01"/>
    <dbReference type="GeneID" id="20673371"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_416899"/>
    <dbReference type="HOGENOM" id="CLU_2171404_0_0_1"/>
    <dbReference type="InParanoid" id="W4KC01"/>
    <dbReference type="OrthoDB" id="3214103at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="110" mass="12202" checksum="BA480E91444812F2" modified="2014-03-19" version="1">MGDIMAYVGLGLSLLINVVAISSIGITAWRHRQSLMSNLGQSSRRTQVEKILILVIESSLLYCLANVILTSCRTICLPGHNPLSQHMWPISTHIAASIFFVIFEPWHDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCH0</accession>
    <name>W4KCH0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_439473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545091.1">
        <property type="nucleotide sequence ID" value="XM_009546796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCH0"/>
    <dbReference type="GeneID" id="20675148"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_439473"/>
    <dbReference type="eggNOG" id="ENOG502SVVK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106822_0_0_1"/>
    <dbReference type="InParanoid" id="W4KCH0"/>
    <dbReference type="OrthoDB" id="2687560at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="254" mass="27961" checksum="F9E19D4F98100868" modified="2014-03-19" version="1">MSAALAPCSFTMDDPSNDVDHRREPSLVAPDFHDIDNKLVVFPQSMMSTSHSLPPLLETHRTLRRKQGMTVIRKKSSRLLRNCASISALQRPESSRDEAGKRASIAFSSASDPRVHSDVRLGHPSRPYYTAIRKNMSPANPYLPASTPLPTGRSSFTLSNRPVSNLSPADIAHTHPDPPVTLPRGSMSVSSPFEGGFSLSGEVELHMALARVRSRDSPREPQEFRFSETRRDVTVKGTVKKLGKGLKKLVLGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCL0</accession>
    <name>W4KCL0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_439620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545364.1">
        <property type="nucleotide sequence ID" value="XM_009547069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCL0"/>
    <dbReference type="GeneID" id="20675170"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_439620"/>
    <dbReference type="HOGENOM" id="CLU_2794249_0_0_1"/>
    <dbReference type="InParanoid" id="W4KCL0"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845370" description="Secreted protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="68" mass="7435" checksum="280EF4128168CB27" modified="2014-03-19" version="1">MITMPCLSHGHSAFAIIASLLIVSVFDQHQYPPRGVPLPVVARVYSTSVCIHGSRSVRVLQVGYLVRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCN8</accession>
    <name>W4KCN8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_123426</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543328.1">
        <property type="nucleotide sequence ID" value="XM_009545033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCN8"/>
    <dbReference type="FunCoup" id="W4KCN8">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="GeneID" id="20666826"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_123426"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012970_2_1_1"/>
    <dbReference type="InParanoid" id="W4KCN8"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore-iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000197">
        <property type="entry name" value="Siderophore iron transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF92">
        <property type="entry name" value="GLUTATHIONE EXCHANGER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="518"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW83548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="551" mass="59737" checksum="3EC38128BE7FC5A6" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCS2</accession>
    <name>W4KCS2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">Cystathionine beta-lyase</fullName>
            <ecNumber evidence="5">2.7.1.36</ecNumber>
            <ecNumber evidence="6">4.4.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="27">Cysteine-S-conjugate beta-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="34" type="ORF">HETIRDRAFT_439505</name>
    </gene>
    <organism evidence="34 35">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="34 35" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="34 35">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17065"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.36"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:17066"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>L,L-cystathionine + H2O = L-homocysteine + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13965"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:18121"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29256"/>
            <dbReference type="ChEBI" id="CHEBI:58717"/>
            <dbReference type="EC" id="4.4.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="26">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from L-cystathionine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="25">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="5"/>
    <dbReference type="EC" id="4.4.1.13" evidence="6"/>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545168.1">
        <property type="nucleotide sequence ID" value="XM_009546873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCS2"/>
    <dbReference type="STRING" id="747525.W4KCS2"/>
    <dbReference type="GeneID" id="20675156"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_439505"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1511">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009484_2_0_1"/>
    <dbReference type="InParanoid" id="W4KCS2"/>
    <dbReference type="OrthoDB" id="2545919at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047804">
        <property type="term" value="F:cysteine-S-conjugate beta-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000013">
        <property type="entry name" value="Cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000009">
        <property type="entry name" value="Cystathionine gamma-synthase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000003">
        <property type="entry name" value="Mevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006238">
        <property type="entry name" value="Cys_b_lyase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01329">
        <property type="entry name" value="cysta_beta_ly_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF50">
        <property type="entry name" value="CYSTATHIONINE BETA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="19" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="23" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="22" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="18" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="32">
        <location>
            <begin position="573"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="33">
        <location>
            <begin position="765"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00029310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00046315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00047517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00047625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00072331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="EMBL" id="ETW82856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="914" mass="99001" checksum="0E5D2F0E7AF205EF" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCV9</accession>
    <name>W4KCV9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_417157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545452.1">
        <property type="nucleotide sequence ID" value="XM_009547157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCV9"/>
    <dbReference type="GeneID" id="20673389"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_417157"/>
    <dbReference type="eggNOG" id="ENOG502SQZU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063099_3_0_1"/>
    <dbReference type="InParanoid" id="W4KCV9"/>
    <dbReference type="OrthoDB" id="3259746at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487:SF3">
        <property type="entry name" value="CLEAVAGE_POLYADENYLATION SPECIFICITY FACTOR A SUBUNIT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845307" evidence="1">
        <location>
            <begin position="22"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="219" mass="21398" checksum="8C31EA45ADD0D747" modified="2014-03-19" version="1">MFSTLVSATLVSVLAIQGARAAFTIDTPVLTQCQDTHITWSQSQAPYNLLIVPSADPCGDSLADLGDHNGLSMTWKVNLAAGTKVMLSLEDGSSDEAWSADIVVQPSNDTSCLSGAAASSVIASASAAASSIASAIASASAVTSAVPTTLSIAYTGKPASVVTSAVASGTSSSSGATVSALGAANAGANPFSSGAPAARSLYKPAMIFGALGAALAIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDU0</accession>
    <name>W4KDU0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TFIID-18kDa-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_457979</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SPT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543737.1">
        <property type="nucleotide sequence ID" value="XM_009545442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDU0"/>
    <dbReference type="FunCoup" id="W4KDU0">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KDU0"/>
    <dbReference type="GeneID" id="20676875"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_457979"/>
    <dbReference type="eggNOG" id="KOG3902">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038706_2_0_1"/>
    <dbReference type="InParanoid" id="W4KDU0"/>
    <dbReference type="OrthoDB" id="66982at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22926">
        <property type="entry name" value="HFD_SPT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000023">
        <property type="entry name" value="transcription initiation protein SPT3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF16">
        <property type="entry name" value="TRANSCRIPTION INITIATION PROTEIN SPT3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="271"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW84017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="40517" checksum="0CA41E9914B02842" modified="2014-03-19" version="1">MPPAPKPPVGGDIEKRKEYKYQQEISQMMFVFGEIQDPLTETVNLVEDIIRSQLVELIVQARVQANRRGARYLSAEDLIFLIRHDRAKVNRLRTYLSWKDVRKHAKDSNADGGGGVEVETLEDGADDKLTAKAQKITIKLPWEITTIYSEVLRQSGLQEDDEEDEDDLEAQEASLERLKEADDVTKQMTREEYQHYSDCRQASFSYRKAKRFREFLNLPPHLDLKANDDTVDIVGFLAFEMVRSLTVASLEVKKSLEESYLREDHTASPVLGKRKMGVGLDSSSKRRREESPDEDSDTPLPASSLFMQPPEARTALRPEHIQDAFGRMQGDWSQSRSAGMRNWRGGLIRTSVSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEE4</accession>
    <name>W4KEE4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_48586</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543243.1">
        <property type="nucleotide sequence ID" value="XM_009544948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEE4"/>
    <dbReference type="FunCoup" id="W4KEE4">
        <property type="interactions" value="434"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KEE4"/>
    <dbReference type="GeneID" id="20678073"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_48586"/>
    <dbReference type="eggNOG" id="KOG1167">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_118_2_1"/>
    <dbReference type="InParanoid" id="W4KEE4"/>
    <dbReference type="OrthoDB" id="10020333at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14019">
        <property type="entry name" value="STKc_Cdc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF23">
        <property type="entry name" value="CDC7 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="52"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW84217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="372" mass="42746" checksum="28E1F05D1BA5B80E" modified="2014-03-19" version="1" fragment="single">MEEDEEEEDDEDDDDEFDEEMTIYLKSNVEQEEIREEIADLERNVPSLLPDYRIVDRLGTGTFSSVYKALDVGYHTKWDNTAWHGHHPSTSSAHYQSAIRPSGSKVFVAIKRIYVTSNPERIRNEIMIMEDCRGCRHVSQLITAFREEDQIVAIMPYHRNGDFREMYRLLSLEGVKTYFRCMFRALRDIHARGIIHRDVKPANFLFDPYTGTGTLCDFGLACRLERGPNAGACLHTPYQRGHPHGRIRKHDEYDTTHIKKMQKDARAKCHRPSDRVGYLDNDPRPHSKANRAGTRGFRAPEVLLKCGDQTGAIDVWSAGMILLFFLIKKFPLFQSGDDVEALVEIASIIGKRRMEKIATLHSRTFATNIPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEV2</accession>
    <name>W4KEV2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">GST3</name>
        <name evidence="5" type="ORF">HETIRDRAFT_34834</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543170.1">
        <property type="nucleotide sequence ID" value="XM_009544875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEV2"/>
    <dbReference type="FunCoup" id="W4KEV2">
        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KEV2"/>
    <dbReference type="GeneID" id="20671778"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_34834"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_14_0_1"/>
    <dbReference type="InParanoid" id="W4KEV2"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="7"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="103"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW84363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="222" mass="25487" checksum="CE39853BF29D1A98" modified="2014-03-19" version="1">MSSNSLKLYTASTPNGRKVSIFLEELKAAYGIEYDVQRIDMSKVEQKEPWFIKINPNGRIPAIVDRTRGGPDGFPVFESAAILLYLAQHKDTEHRFWFKPDEQPEDYSEMLQWIFFAHGGIGPMQGQAGHFIRLSEDIPYGKKRYTDETKRLYGVLEIRLKDRDYLAGPGRGVYSLADINSYPWVAMHNYVNISLDEWPAVKAWVERMAEKPAVKSGWQIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEY1</accession>
    <name>W4KEY1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_438870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
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                <person name="Kues U."/>
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                <person name="Lind M."/>
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        </citation>
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            <end position="35"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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</entry>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Asiegbu F."/>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
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                <person name="Cullen D."/>
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                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
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                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
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                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
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                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
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                <person name="Yakovlev I."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
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    </dbReference>
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        <property type="entry name" value="DNA REPAIR PROTEIN RAD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RING/U-box"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
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        <location>
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            <end position="571"/>
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    </feature>
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        <location>
            <begin position="742"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
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            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="264"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="11"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW84428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="999" mass="111303" checksum="F921DC2421AA69F9" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KF43</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543446.1">
        <property type="nucleotide sequence ID" value="XM_009545151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KF43"/>
    <dbReference type="STRING" id="747525.W4KF43"/>
    <dbReference type="GeneID" id="20669944"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_312309"/>
    <dbReference type="HOGENOM" id="CLU_035509_15_2_1"/>
    <dbReference type="InParanoid" id="W4KF43"/>
    <dbReference type="OrthoDB" id="3258294at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="334" mass="38251" checksum="EC09869AD86E7517" modified="2014-03-19" version="1">MTSKVINLDREVIYHVKSEFKQTFIRVWAFQVEFIWGQKKNRLGFWLYVFVSANRLFNLRNNNLRSRCSAKDVSLGAEAIVSPFTHTKSCSCITYLTLDDAVTLLITIVTQTILQIRVYALYVQSRSILIFLLCCCALEVLTMLVLAVITMDRLSHFPVISTATGCYYSGLSRPSAIFWIPPLIYELILCLLVVWKAWDEEILYRFGLGPHTSDGQPLFTTPCMVKLIARDSLRYFSAIFVEFVISTVIWSHYKYYVDVTMPWACALPSILGSRLFINMRESMLETSNQNSYVLETFQFATRPVLESADARRDPELTADALHPHMTSAPDVELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KF53</accession>
    <name>W4KF53_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fms interacting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_449547</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543667.1">
        <property type="nucleotide sequence ID" value="XM_009545372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KF53"/>
    <dbReference type="STRING" id="747525.W4KF53"/>
    <dbReference type="GeneID" id="20675961"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_449547"/>
    <dbReference type="eggNOG" id="KOG2216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082754_1_0_1"/>
    <dbReference type="InParanoid" id="W4KF53"/>
    <dbReference type="OrthoDB" id="20582at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019163">
        <property type="entry name" value="THO_Thoc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375">
        <property type="entry name" value="FMS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375:SF3">
        <property type="entry name" value="THO COMPLEX SUBUNIT 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09766">
        <property type="entry name" value="FmiP_Thoc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW83940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23419" checksum="DA0057F9CE30AB9A" modified="2014-03-19" version="1">MDLPPSPDSVIDALRDLTDPASQLKDTSTVHARAGALFARLKALNRAANVATKAHKQATADARHHMDQTHLELQNLLYEKRHLEREIDKCRQFASIYQDIPMYTVDQFVELAPPEAHAEDVMSNQHQLMLNRLSFELQPRHRLDQRVKELTQQKEELLRDSKSKLVTMESVKVQIDTLVKTASEIRKKVDELVPSTVSPVGTPLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4KF85</accession>
    <name>W4KF85_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar sorting protein VPS24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_313829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543694.1">
        <property type="nucleotide sequence ID" value="XM_009545399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KF85"/>
    <dbReference type="FunCoup" id="W4KF85">
        <property type="interactions" value="255"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KF85"/>
    <dbReference type="GeneID" id="20670067"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_313829"/>
    <dbReference type="eggNOG" id="KOG3229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069208_0_1_1"/>
    <dbReference type="InParanoid" id="W4KF85"/>
    <dbReference type="OrthoDB" id="2329734at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="24497" checksum="DEDB6B77344E153F" modified="2014-03-19" version="1">MQSINRFLYGPTPEEKVRGWQSKLRQESRTLDREMRQLDLETNKARSTVKQLAKKGDVKSARILAREIVRSNKQKDRLSVSKARLSSIGTQLTQQLAMSKVTGSLQKSTEIMKLSNNLIKLPQISQTMRDMSMEMTKAGILDEMLADTFEVDEDDEIEEEADAEVDKVLFDLTNGKLGQVGSVETGLPSLQDQLEEEEAEREMEKYREQLNGLLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFJ4</accession>
    <name>W4KFJ4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_415545</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543547.1">
        <property type="nucleotide sequence ID" value="XM_009545252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFJ4"/>
    <dbReference type="STRING" id="747525.W4KFJ4"/>
    <dbReference type="GeneID" id="20673257"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_415545"/>
    <dbReference type="eggNOG" id="KOG2121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031317_4_0_1"/>
    <dbReference type="InParanoid" id="W4KFJ4"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46018">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46018:SF2">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23023">
        <property type="entry name" value="Anti-Pycsar_Apyc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW83801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="377" mass="41013" checksum="85459357C2897D37" modified="2014-03-19" version="1">MISSINITFLGTASAQPSSTRNHSALALRLSGGVWLFDCGEATQHQIQRSQVKMGKIEKIFITHTHGDHIFGILPLLASRLNGAGGITEGEDSRAEEPIEIYGPLGTRAYIRNGLSYSHTLLGGPYVVHELRFPTDPQDGDFTSLPRLPFESPTGRNISQANGIWTDIFKNDLISVSAAPILHSVPCVGYVVTEAPVPGKIDPRQYIPHIKRTGAPMTVMRRVQQGESVELPDGTVLRGPDRRQGRKLAILGDTYDPSPIADLAAGVDILIHEATNAYLRGVVAETKESDTVESVEARTKLRGHSTPQMAGAFAQRIAAKKLVLNHFSARYAGDDHKDPLARTTMNAIKALAQENYNGPVVCARDFMSFDVEFSSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFN5</accession>
    <name>W4KFN5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_103195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544305.1">
        <property type="nucleotide sequence ID" value="XM_009546010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFN5"/>
    <dbReference type="GeneID" id="20665874"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_103195"/>
    <dbReference type="HOGENOM" id="CLU_850085_0_0_1"/>
    <dbReference type="InParanoid" id="W4KFN5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="327" mass="35957" checksum="48046F55A1140A38" modified="2014-03-19" version="1">MAAGGSADAGGSTACKRPVSFARFPVCADFFKASSSQATEISAVTTSFESRDLTSAMHDTRLQERAVRRSTGVLLSGIHEQWEQERARHKEELAALFARQLQELRGEMEGMLEKAVEKAAGKAEREQEMRDVVLAKRLEKAEGAGEATARVGTQEKLQLDSRFKTDHEQLQATVHRQVEHMAMLSEHKKSKVRCRQLTTVESLVPSEVCPSDHGCSGIVGLAHTIEGLCNLIKPTKAFDKIVAAGCKDKERLATAKGLFTGSTSDKVLALRLLKSPAGYLVVRRFAPLRRKAPVDRELEGIQPAGDRLHSQTRDGILLLVFFVCDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFV5</accession>
    <name>W4KFV5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_314076</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544258.1">
        <property type="nucleotide sequence ID" value="XM_009545963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFV5"/>
    <dbReference type="STRING" id="747525.W4KFV5"/>
    <dbReference type="GeneID" id="20670087"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_314076"/>
    <dbReference type="eggNOG" id="KOG4210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_15_1_1"/>
    <dbReference type="InParanoid" id="W4KFV5"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="100"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="169"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW84609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="257" mass="26861" checksum="63664D0372B4A34F" modified="2014-03-19" version="1" fragment="single">TIFVGRLSWNVDNDWLASEFAECGEVVNARVQMDRNTGKSRGFGYVEFKTAEAVESALKLNGKEIDGRPVNIDKSHGVDKSTSRDNRAKTFGDSTSPPTSTLFVGNLSYDATEDALWEVFAEYGEVKSIRVPTDRETGKVKGFGYVEFTDLESSKKALEALNGQDIAGRNVRLDYSQPRDDSGGSRGGRGGGGFGGRGGGRGGGRDGGFGGRGGGGFGGRGGGRGGPRGGGRGAPRGRGGPRTGGITSFEGKKTTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KG22</accession>
    <name>W4KG22_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_408703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_408703"/>
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    <dbReference type="InParanoid" id="W4KG22"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="384"/>
        </location>
    </feature>
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        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
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            <begin position="202"/>
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        </location>
    </feature>
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            <begin position="330"/>
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        </location>
    </feature>
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            <begin position="363"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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    </organism>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="94"/>
            <end position="141"/>
        </location>
    </feature>
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        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
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            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="141" mass="15258" checksum="A515C554EBBB9542" modified="2014-03-19" version="1" fragment="single">MHWWCHSQRAALLYCQDAHVTRSRRGLHVRSSMTGYTQSSDARMRFRSHDAGLHFAAMFAHPAPSFAAHPFPFPAPIPFSLPTWASTSTPVLAPHRRIPHAPSSTPAPVLEIPTGPVSPVPEESPSPATPAAPLTTIAPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGL9</accession>
    <name>W4KGL9_HETIT</name>
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    </protein>
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        <name evidence="2" type="ORF">HETIRDRAFT_416467</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
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                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_416467"/>
    <dbReference type="HOGENOM" id="CLU_050560_0_0_1"/>
    <dbReference type="InParanoid" id="W4KGL9"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
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        </location>
    </feature>
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        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="88"/>
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        </location>
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        <location>
            <begin position="432"/>
            <end position="447"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="465" mass="50809" checksum="0923A2E9D6D5A599" modified="2014-03-19" version="1">MLLHEDHDASSPSRNSSPDVVLMVSNPDIGRVDRGASPHPSNAGRIDRGTSPHRPEPAVVTLTPHLNDFSDDDTEDYTKFKERERTRQPSSQGPPRDASQNENPDDRNLPGSDEVPVGVPPPATITASIGAAGPSGLRARIAAQLPSHGETESIPVIQGATPPPVPTGGQIPCSMGRTTLGTDPHARELERHADALLQRSTISAVIQMATAMALQRLANFAAGQPGNEHSDIPRRLASASLQIRGLALQTDPDTASWYEHNDGRPRALLIHPDEFSQYVNRELLPALLFTGELGTVQPSRTDPFRIVVWNVPRPGERPTAVPNPRRTPHTVVERPSPRPRESCPAHSNPTTSSSHRVRNFPLSHGGTDEEELPATLRRGTTTGGSVRHRPGTPPPSARFRTDEGQNNRSSRRTRRANSEARRNRSWTRSELDAWDALDDPGNYDDADPYYRPDEGGNGYQGPYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGN2</accession>
    <name>W4KGN2_HETIT</name>
    <protein>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">HETIRDRAFT_408719</name>
    </gene>
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            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544491.1">
        <property type="nucleotide sequence ID" value="XM_009546196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGN2"/>
    <dbReference type="GeneID" id="20672704"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_408719"/>
    <dbReference type="HOGENOM" id="CLU_1927893_0_0_1"/>
    <dbReference type="InParanoid" id="W4KGN2"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="131" mass="13099" checksum="7CDE79A1BDA4D17C" modified="2014-03-19" version="1">MRLNPLSKGQAPLLPSLPFLTALPLTSLAVTIPFPISSTVSLNTLASATTSPSPSSTLALFSGVCSSPSLRRFLVSRRKTDGSHRGSIRASMMGAVGVAGVAGVAGYGTPLDAGLNGTGVAVDAGTCGTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGU3</accession>
    <name>W4KGU3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_414203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541964.1">
        <property type="nucleotide sequence ID" value="XM_009543669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGU3"/>
    <dbReference type="GeneID" id="20673160"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_414203"/>
    <dbReference type="HOGENOM" id="CLU_1731689_0_0_1"/>
    <dbReference type="InParanoid" id="W4KGU3"/>
    <dbReference type="OrthoDB" id="2884925at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="17578" checksum="32285E4D036708D5" modified="2014-03-19" version="1">MEEAQSVPRPATGQLILFDLRNVNQISRHLLTPDLDIRIVDPRAHNEALPISQTPNEVLERHFHFCLDRQERHHQRLVFAAGCVYLRLTPYPEWLQITRICSRWCRVALGYSRLWSTIASDSKQRFDLCIEKLPPKQVIDVALKITDNQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHB7</accession>
    <name>W4KHB7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Bifunctional P-450:NADPH-P450 reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">cpr1</name>
        <name evidence="20" type="ORF">HETIRDRAFT_124013</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 17">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544115.1">
        <property type="nucleotide sequence ID" value="XM_009545820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHB7"/>
    <dbReference type="STRING" id="747525.W4KHB7"/>
    <dbReference type="GeneID" id="20666857"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_124013"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_7_0_1"/>
    <dbReference type="InParanoid" id="W4KHB7"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070330">
        <property type="term" value="F:aromatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06206">
        <property type="entry name" value="bifunctional_CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11068">
        <property type="entry name" value="CYP120A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000040">
        <property type="entry name" value="Bifunctional cytochrome P450/NADPH--P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000198">
        <property type="entry name" value="Bifunctional cytochrome P450/NADPH--P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023206">
        <property type="entry name" value="Bifunctional_P450_P450_red"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF127">
        <property type="entry name" value="BIFUNCTIONAL CYTOCHROME P450_NADPH--P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000209">
        <property type="entry name" value="Bifunctional_P450_P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="6 17" id="KW-0349">Heme</keyword>
    <keyword evidence="13 17" id="KW-0408">Iron</keyword>
    <keyword evidence="9 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="18">
        <location>
            <begin position="492"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="19">
        <location>
            <begin position="675"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="17">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000209-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ETW84441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1078" mass="118421" checksum="FE12A3597B450677" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHM9</accession>
    <name>W4KHM9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcium-binding protein NCS-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_439269</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544236.1">
        <property type="nucleotide sequence ID" value="XM_009545941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHM9"/>
    <dbReference type="FunCoup" id="W4KHM9">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KHM9"/>
    <dbReference type="GeneID" id="20675122"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_439269"/>
    <dbReference type="eggNOG" id="KOG0044">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072366_1_2_1"/>
    <dbReference type="InParanoid" id="W4KHM9"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000009">
        <property type="entry name" value="Visinin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF178">
        <property type="entry name" value="NEUROCALCIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW84586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="190" mass="22232" checksum="38F210302F441788" modified="2014-03-19" version="1">MGKSQSKLSPEQLADLQKNTYFDKRELQQWYKGFLKDCPSGQLDKTEFSRIYKQFFPFGDPGEFADYVFDVFDENKNGTIDFKEFICALSVTSRGRLDEKLRWAFQLYDIDKDGTITYQEMLQIVQSIYKMTGQMVKLPPDEDTPEKRVDKIFRNMDRDKDAKLTYDEFVEGSKQDPTIVQALSLYDGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIK5</accession>
    <name>W4KIK5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">transketolase</fullName>
            <ecNumber evidence="4">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HETIRDRAFT_379532</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542389.1">
        <property type="nucleotide sequence ID" value="XM_009544094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIK5"/>
    <dbReference type="FunCoup" id="W4KIK5">
        <property type="interactions" value="377"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KIK5"/>
    <dbReference type="GeneID" id="20671972"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_379532"/>
    <dbReference type="eggNOG" id="KOG0523">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_0_0_1"/>
    <dbReference type="InParanoid" id="W4KIK5"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049557">
        <property type="entry name" value="Transketolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
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        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TRANSKETOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
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    </dbReference>
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        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="15">
        <location>
            <begin position="359"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="120"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="530"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049473"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR605478-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR605478-3"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR605478-4"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR605478-5"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETW85539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="686" mass="73801" checksum="31E95E6B551C6C86" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIP0</accession>
    <name>W4KIP0_HETIT</name>
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        <recommendedName>
            <fullName evidence="1">Piwi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_309780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="747525.W4KIP0"/>
    <dbReference type="GeneID" id="20669712"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_309780"/>
    <dbReference type="eggNOG" id="KOG1041">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004544_4_3_1"/>
    <dbReference type="InParanoid" id="W4KIP0"/>
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    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNaseH-like_sf"/>
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    </dbReference>
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        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="403"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="745" mass="82745" checksum="FB6FB212D24A0A67" modified="2014-03-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIX9</accession>
    <name>W4KIX9_HETIT</name>
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        <recommendedName>
            <fullName evidence="5 16">CDP-diacylglycerol--inositol 3-phosphatidyltransferase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HETIRDRAFT_44242</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16 17">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.11" evidence="5 16"/>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541809.1">
        <property type="nucleotide sequence ID" value="XM_009543514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIX9"/>
    <dbReference type="FunCoup" id="W4KIX9">
        <property type="interactions" value="497"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014387">
        <property type="entry name" value="CDP_diag_ino_3_P_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000848">
        <property type="entry name" value="CDP_diag_ino_3_P"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 16" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00010441"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013212"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ETW85787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="257" mass="28894" checksum="A9EC799C7A59D11B" modified="2014-03-19" version="1">MSGKQPIQRRRRHSDVVDPKQAVDLATAQTYSENVFLFVPNLIGYSRVLLAAVALHFMSYHPKYCTLAYCISCLLDAVDGQAARALGQTSKFGAVLDMVTDRCTTSCLLCYLASVYPDFALFFQFLIALDFASHYMHMYSSLVTGSRSHKLVTSDVSRILWLYYNDSRTLFVICAGNEMFFVALYLMKWVQTPIGLGHPLVEDLTWPQLIAIPTGIISFIKNIINVVQLWKASKILVGVDLAERKQAREEGMRSKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIZ1</accession>
    <name>W4KIZ1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_308737</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ETW85689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009544229.1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="eggNOG" id="KOG4150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="W4KIZ1"/>
    <dbReference type="OrthoDB" id="18781at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17923">
        <property type="entry name" value="DEXHc_Hrq1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SF2_C_Hrq"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="HRQ1_WHD"/>
    </dbReference>
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        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957:SF3">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="MZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22982">
        <property type="entry name" value="WHD_HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="140"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="380"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW85689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="913" mass="102595" checksum="3BC581CDE1500170" modified="2014-03-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJ36</accession>
    <name>W4KJ36_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_448320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541972.1">
        <property type="nucleotide sequence ID" value="XM_009543677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJ36"/>
    <dbReference type="GeneID" id="20675847"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_448320"/>
    <dbReference type="eggNOG" id="ENOG502T2EC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1354769_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJ36"/>
    <dbReference type="OrthoDB" id="3155837at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="32"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW85086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="202" mass="22355" checksum="FADE8D4FB2C77147" modified="2014-03-19" version="1">MVTVDVLKLDFVSPLTQPPVGKIPIDVPFLPAFLDVAVTGILLTFLLRSRADIYSKRFRRVVTRLMIVAWEAAIPPCACAVTALVTYFTLVNVNYWDLTFQAILGKLYVISLFVTLNGRADIDAQRSHFPTFSNIISPTTGPSIRLSNTRPPEFVAARPSGTISFSSVHQTPTSDVETEGSQDDLERGRRWISRTPGSDLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJJ0</accession>
    <name>W4KJJ0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_414310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542104.1">
        <property type="nucleotide sequence ID" value="XM_009543809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJJ0"/>
    <dbReference type="GeneID" id="20673166"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_414310"/>
    <dbReference type="HOGENOM" id="CLU_1686824_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJJ0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="17750" checksum="3461E29023853606" modified="2014-03-19" version="1">MSSIHRTHAALALPLQASKHHPGPSVVQAHLTFSNRNCEPILPFDTRTKPCDAPKAILQMSAIDYWSPPAQLRLDLLSDLSVTASVNDPNIYRIFDDEVAFLRNTIRAINAWRNDIIPMCHLPSETLAHIFYFLAVIDPPWIRDLGWIKISHICRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KK63</accession>
    <name>W4KK63_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_309749</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543009.1">
        <property type="nucleotide sequence ID" value="XM_009544714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KK63"/>
    <dbReference type="FunCoup" id="W4KK63">
        <property type="interactions" value="292"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KK63"/>
    <dbReference type="GeneID" id="20669708"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_309749"/>
    <dbReference type="eggNOG" id="KOG1535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_5_0_1"/>
    <dbReference type="InParanoid" id="W4KK63"/>
    <dbReference type="OrthoDB" id="74910at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000003">
        <property type="entry name" value="Fumarylacetoacetate hydrolase domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="10"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW86253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="227" mass="24766" checksum="A222E66753F907C0" modified="2014-03-19" version="1">MAAFVRNGKKIVAIGRNYVDHVKELNNAIPKEPFFFLKPTTSYLPFGGNVEIPRGIIAHHEVELGLVIGKGGRDISQENAGSHIAGYALAVDMTARNFQDEVKKKGLPWSAVKGFDTFTPISSFVPKSEVTDPHNLKLWLKVNGQFKQNGVTSHMIFRIPRLIEHISSIMALEEGDLILTGTPSGVGPLSIGDQVTCSLSDGSTDKELAKLEFGTVLRGGGYFYQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKS1</accession>
    <name>W4KKS1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_415229</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 22 family. PIGB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543039.1">
        <property type="nucleotide sequence ID" value="XM_009544744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKS1"/>
    <dbReference type="FunCoup" id="W4KKS1">
        <property type="interactions" value="548"/>
    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_415229"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012353_0_1_1"/>
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    <dbReference type="OrthoDB" id="416834at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845467" description="Mannosyltransferase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006065"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW86284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="562" mass="61279" checksum="46C8569AFE3F7AA8" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLK9</accession>
    <name>W4KLK9_HETIT</name>
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        <recommendedName>
            <fullName evidence="3 9">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_468343</name>
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    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
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            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
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                <person name="Solheim H."/>
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                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the histone H3 family.</text>
    </comment>
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        <property type="protein sequence ID" value="ETW86712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000001">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
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        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="46"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00020835"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW86712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="138" mass="15440" checksum="8338A7221DC59F25" modified="2014-03-19" version="1">MARTKQTARKSTGGKAPRKQLATKAARKTAAAAATGGVKKPHRFRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEAAEAYLVSLFEDTNLAAIHAKRVTIQPKDLALARRLRGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KM69</accession>
    <name>W4KM69_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_447229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540494.1">
        <property type="nucleotide sequence ID" value="XM_009542199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KM69"/>
    <dbReference type="GeneID" id="20675746"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_447229"/>
    <dbReference type="eggNOG" id="ENOG502S72V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058661_0_0_1"/>
    <dbReference type="InParanoid" id="W4KM69"/>
    <dbReference type="OrthoDB" id="6162636at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="395" mass="42481" checksum="10802CBECDE00D17" modified="2014-03-19" version="1">MVRNLNNYKQGNITKRYNGAKKFEYKMVPIGSKRLMDVYRHSRPDCADEENSASSYQYPFGNLPTLVSHVQPHWVILNAGMKLDSRSECEMDAFYERVAHAYDISRTVAISFIKDIIDLNAKWRSPTPQEVASPKVALPKITIPKVTLPKVTLPKVALPKVARSKVVLPKAASPEVALSKVASPEVALSKVAPLQVAPPQVASPEVASLQVALPEVALSKVASPEVALSKVAPLQVAPPQVASPEVASLQVALPEVALSKVASPEVALSKVAPLQVAPPKVALPEGASTAQVVSPQVAPPKVALPEGASTTQVVSPEVADVVDVVDDISGEDNDSRSNKSSDSHRFIKPMTTTLQHYLHKRSSSSPHSPSLRSPVREVKRSKISPTYSGRKPKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMR4</accession>
    <name>W4KMR4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_425208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543069.1">
        <property type="nucleotide sequence ID" value="XM_009544774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMR4"/>
    <dbReference type="STRING" id="747525.W4KMR4"/>
    <dbReference type="GeneID" id="20674023"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_425208"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001324_5_4_1"/>
    <dbReference type="InParanoid" id="W4KMR4"/>
    <dbReference type="OrthoDB" id="2272314at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="695" mass="79497" checksum="18AC2F79701112C9" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMT5</accession>
    <name>W4KMT5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HETIRDRAFT_413081</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540688.1">
        <property type="nucleotide sequence ID" value="XM_009542393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMT5"/>
    <dbReference type="FunCoup" id="W4KMT5">
        <property type="interactions" value="411"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KMT5"/>
    <dbReference type="GeneID" id="20673089"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_413081"/>
    <dbReference type="eggNOG" id="KOG0922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_2_0_1"/>
    <dbReference type="InParanoid" id="W4KMT5"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17971">
        <property type="entry name" value="DEXHc_DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21691">
        <property type="entry name" value="GH2-like_DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05684">
        <property type="entry name" value="S1_DHX8_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000061">
        <property type="entry name" value="ATP-dependent RNA helicase DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2130:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000101">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000191">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044762">
        <property type="entry name" value="DHX8/Prp22_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049588">
        <property type="entry name" value="DHX8_GH2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049621">
        <property type="entry name" value="S1_DHX8_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="204"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="511"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="699"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="139"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETW86690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1163" mass="131022" checksum="9E0A929559890D07" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4KN39</accession>
    <name>W4KN39_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_447441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540761.1">
        <property type="nucleotide sequence ID" value="XM_009542466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KN39"/>
    <dbReference type="STRING" id="747525.W4KN39"/>
    <dbReference type="GeneID" id="20675777"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_447441"/>
    <dbReference type="eggNOG" id="ENOG502SN2M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049938_0_0_1"/>
    <dbReference type="InParanoid" id="W4KN39"/>
    <dbReference type="OrthoDB" id="3229208at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="466" mass="49103" checksum="E9D153B831FB6D43" modified="2014-03-19" version="1">MFRASPWISYDPASGDPRTEDLTTTAIAHNHSESDMDEDVDMDAPHISTLREEDSPPPQSSPSHTGKFRVNLVVNEPKPGTKFITFNGETGEEARESDEADEEEDVEEEEEDQLIDDDEEGISSTVVTPGPSAPGPSTRGAAPTKRGKGRGGGTKRKGRTGALNPAPLMTTFEVSPPASHAVRTSPSRDVADPVDGEGSSHATILALKKAVPKGTTAAQRAPRKSGPKYSQLYYLSTPVHDELSEGYTGTAPSSPTRHEAHTPEVESITAPALLGVPQVDEFNLDTVALPRYPLPSKPFYVQPPPKIGNGYAPVIPLDRSGKKVRHWRTANREIRGIAGGRWFARSWVGEKDSELASAAAAATAANQQAAAAAAVETERLAGGSGSLTLPKLPTLSLSAPPAGRVGNKARAGKVETVASSATSRSVSAVPDVASVSVSPGIRAATRKKSQLSIAVSEVDKDIELVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4KN82</accession>
    <name>W4KN82_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Het-C-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_121390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540812.1">
        <property type="nucleotide sequence ID" value="XM_009542517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KN82"/>
    <dbReference type="STRING" id="747525.W4KN82"/>
    <dbReference type="GeneID" id="20666750"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_121390"/>
    <dbReference type="eggNOG" id="ENOG502QRXF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010063_2_0_1"/>
    <dbReference type="InParanoid" id="W4KN82"/>
    <dbReference type="OrthoDB" id="2506204at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845605" description="Het-C-domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="780"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="852"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="865"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="877"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW86830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="913" mass="100900" checksum="FEE32791992332D6" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4KP23</accession>
    <name>W4KP23_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine protease 26A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_42324</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S26 family. IMP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540357.1">
        <property type="nucleotide sequence ID" value="XM_009542062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KP23"/>
    <dbReference type="FunCoup" id="W4KP23">
        <property type="interactions" value="311"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KP23"/>
    <dbReference type="GeneID" id="20673887"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_42324"/>
    <dbReference type="eggNOG" id="KOG0171">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028723_4_3_1"/>
    <dbReference type="InParanoid" id="W4KP23"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052064">
        <property type="entry name" value="Mito_IMP1_subunit"/>
    </dbReference>
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        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383:SF16">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S26" evidence="8">
        <location>
            <begin position="8"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="8">
        <location>
            <begin position="93"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW87454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="146" mass="15810" checksum="3DD5DD4D7D0C5785" modified="2014-03-19" version="1" fragment="single">QTINIGCAIHLFFEYVGRPTLVQGPSMIPTMAESGELVIEYRLPLRLNPNHLQRGDLVTLTSPVQPGRIVCKRVLGLPGDVVCVDPTGMKAPSTEHVVIPKGHIWIMGDNAAASRDSRDYGPVSLSLVRGTLLARVRAIICALGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KRE3</accession>
    <name>W4KRE3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_307090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009543222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KRE3"/>
    <dbReference type="GeneID" id="20669458"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_307090"/>
    <dbReference type="HOGENOM" id="CLU_1740740_0_0_1"/>
    <dbReference type="InParanoid" id="W4KRE3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="150" mass="17440" checksum="D37AF63848154FE9" modified="2014-03-19" version="1">MYQNPDGTPSSPAYTTPLITKESFQAEQQTASPTVFTSTDQAERRPLSLVPVRRPPEPELPSPSVPENRFRTFYQQIILLRWPWKRAYATSKDDVAETRHMVGSPELAPQPTIQPSSGMYSDTRTHFRQWFRKRHIIRVERVQRDTVDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNC3</accession>
    <name>W4JNC3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_67959</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553075.1">
        <property type="nucleotide sequence ID" value="XM_009554780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNC3"/>
    <dbReference type="FunCoup" id="W4JNC3">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="GeneID" id="20678837"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_67959"/>
    <dbReference type="eggNOG" id="KOG2816">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017517_1_0_1"/>
    <dbReference type="InParanoid" id="W4JNC3"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="565"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="616"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="646"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW74979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="711" mass="75294" checksum="295A5185AFC82953" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNJ3</accession>
    <name>W4JNJ3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase class V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_68211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">TC 32-1</strain>
        </source>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008265">
        <property type="term" value="F:molybdenum cofactor sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
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        <property type="entry name" value="Aminotrans_V_dom"/>
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            <end position="557"/>
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    </feature>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="11"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW74635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="623" mass="66340" checksum="9F2E64117EBD5C0F" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNL5</accession>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
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                <person name="Cullen D."/>
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                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
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                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <end position="116"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <end position="110"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW75074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="139" mass="15862" checksum="15E502F5ACFAD1A5" modified="2014-03-19" version="1">MLLAASPTKEEWDVHLQECQRLLMEGLVVRGQLLDERNHDVDDAHARHVRLQPYKTIEELDEFRNPTPMHLALPFLNVFHGLYGGSVPLHQGPRTHAAPRRGQSRQRSGGRGRGSATWRWEVVDDEAIYIGTSHTHSFP</sequence>
</entry>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
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                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Velez H."/>
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                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">TC 32-1</strain>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW75617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
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                <person name="Gonthier P."/>
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                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
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                <person name="Lin Y.C."/>
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                <person name="Lunden K."/>
                <person name="Morin E."/>
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                <person name="de Vries R.P."/>
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                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_330338"/>
    <dbReference type="eggNOG" id="ENOG502SCUH">
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    <dbReference type="InParanoid" id="W4JQ68"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="CDD" id="cd02224">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW75707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="20337" checksum="4B8495A416A86AF2" modified="2014-03-19" version="1">MPTISSPPYLIHSLLEPRPNFEHPLDPAARRQQLSLGLRTGLTRTGVHLCRLEPQMESTILHWHTADDEWLYIISCGPNASIIVHETSDEGKDEVKEVPLQTGDFLGFPAGMRTARKLFSGDVDMQYLVGGSREPVDVVHYPTLGKRLVLDRTGSGSSWWVDTANAQDRKKTVFDSTLDSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRI0</accession>
    <name>W4JRI0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">GMC oxidoreductase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">gor1</name>
        <name evidence="12" type="ORF">HETIRDRAFT_148218</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551954.1">
        <property type="nucleotide sequence ID" value="XM_009553659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRI0"/>
    <dbReference type="GeneID" id="20667260"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_148218"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_0_1"/>
    <dbReference type="InParanoid" id="W4JRI0"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="11">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="538"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="581"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW75690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="601" mass="66969" checksum="EDD27B09673CB9CD" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRI6</accession>
    <name>W4JRI6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_162457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551959.1">
        <property type="nucleotide sequence ID" value="XM_009553664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRI6"/>
    <dbReference type="GeneID" id="20667771"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_162457"/>
    <dbReference type="HOGENOM" id="CLU_2979365_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRI6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW75695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="58" mass="6803" checksum="5043598199FA4357" modified="2014-03-19" version="1">MDIRAGVVFVLLSVRGQVNEVQLDHYHTLYSNRRDTHTSVPIRLRCPRPWRLVDSILC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRK6</accession>
    <name>W4JRK6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_144002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552415.1">
        <property type="nucleotide sequence ID" value="XM_009554120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRK6"/>
    <dbReference type="GeneID" id="20667039"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_144002"/>
    <dbReference type="HOGENOM" id="CLU_2455010_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRK6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="89" mass="9460" checksum="4A47607022FB8917" modified="2014-03-19" version="1">MTLVLFDTDGPDAQLDLGVQLLECFRGRSLNTNWCALTGRTYGMKGDASAPSFHSISSKNSLPMPSAPLVNEGVAIMTSSNVPRDANNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRL6</accession>
    <name>W4JRL6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_455424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551986.1">
        <property type="nucleotide sequence ID" value="XM_009553691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRL6"/>
    <dbReference type="GeneID" id="20676618"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_455424"/>
    <dbReference type="HOGENOM" id="CLU_1046056_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRL6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="266" mass="29202" checksum="D0B9A2FA835A1DED" modified="2014-03-19" version="1">MRTREMKTPRNRLDPIDATLNARDQEWYFRTLVLRSRLGPSPPPFPESRSGLHTPPPHGDPSNQGTLRRPWPPRQLATRICAGYIRVSASGGDRAYAIGRTAGSEQYAGKYKHSWTAARTGDRPAQLSDTASPVLFINTNGSPPRLLPTRAHRIAHKLDCIRRSDTRARACTRRRGKGRVLYMAFNSPPGGDAIALVAAVGAGTRLERGHSMQHGPRGGSRTKERGVNKPWTARPEALSVSRSRGAFLKEGSNSRCGTGRLDMPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRQ1</accession>
    <name>W4JRQ1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_430514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552360.1">
        <property type="nucleotide sequence ID" value="XM_009554065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRQ1"/>
    <dbReference type="GeneID" id="20674455"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_430514"/>
    <dbReference type="HOGENOM" id="CLU_1602949_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRQ1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="166" mass="18651" checksum="2CC6006262272BF5" modified="2014-03-19" version="1">MFRADKDGIANGGGPCDSSRGRYNRLIVVSISSFICNSTPLQDGRIGAQRRRTILRSGANIAWSSVRKSAASGKTNRWKGEEIRSATNLSQKSGCEENVEVVTPVHCVAFYEHTLHRTMSERRSNERGETPDVVNIQEGRQREGMIQWACQMSRIWTSKMEDTAWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRZ1</accession>
    <name>W4JRZ1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_327937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551240.1">
        <property type="nucleotide sequence ID" value="XM_009552945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRZ1"/>
    <dbReference type="GeneID" id="20671373"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_327937"/>
    <dbReference type="eggNOG" id="ENOG502T03A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043056_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRZ1"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="390" mass="44866" checksum="41D159E67816984C" modified="2014-03-19" version="1">MNVNGSYARVFLFTMDNDLKVIGRIVLPVREAVKTKAEVAAMDMIRARTNVPVPQVYLYCSSPQNPVRTEWILMEYIRGETLGDCFGSLTFQQKMRTATELAIIMSSLFNIKAARSGSLNPKYGRDDRDFCLRSLRYHLDTPNNLNTLNTSADSHLGVGPINDVTFLDYPRQVSPSRCGPFRSELEFLEAFAFRGHPPTRSDDKLERWAFEKVFEVYHAVRPLYRGFGSSCNADQGDTFHFSHGDLSSWNVLVDPESGGITGVIDWEMAGFRPAWLAAVGCGWFNDDSDRFLMTDDQDGRLGYADDTPTDARLRAHFRLQLAERSMELFRHYWLGVELRAIFYSLCHEYPGNAEVWLEKYENHEWDVARRGRFPFDLMAWIEEKLDLEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSL7</accession>
    <name>W4JSL7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_328972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551429.1">
        <property type="nucleotide sequence ID" value="XM_009553134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSL7"/>
    <dbReference type="GeneID" id="20671461"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_328972"/>
    <dbReference type="HOGENOM" id="CLU_211257_0_0_1"/>
    <dbReference type="InParanoid" id="W4JSL7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="58" mass="6401" checksum="FCB2187CCC8290BC" modified="2014-03-19" version="1" fragment="single">CLIQSQNYLGTIISHSLLLFNMLLISKVITNNSLSLPTLKIVLVLCSVLRDTSSISMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSR1</accession>
    <name>W4JSR1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_245910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551466.1">
        <property type="nucleotide sequence ID" value="XM_009553171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSR1"/>
    <dbReference type="GeneID" id="20669094"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_245910"/>
    <dbReference type="eggNOG" id="ENOG502SNH9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036643_0_0_1"/>
    <dbReference type="InParanoid" id="W4JSR1"/>
    <dbReference type="OrthoDB" id="3178870at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="37446" checksum="BDAEFB02AE5CFA93" modified="2014-03-19" version="1" fragment="single">LSSCLPTEILDHICCDIASPSDLFPLLLTNSVVHPIAARVLYRDLVNLSKTQTVHLLQSLSKPPHPSNDKYLPSRHDFVKNLEINFDDCTLLMSLLTMVRQTLERLPNLKSLLIEFSSSDNRRPLARFFPLNAPFKLRYLTTSVRYDPELAMFLNAQPEIQDLSLRGFQTTGEFKLNPDALPNLRSFRSVHTGPSVISQMITGRPVEAMSLSLYPDDSPELLDTLNLPSTKIKRLTLLMIDCASPYNLFQQLSSRLPDLIALHIVALGVDYNMVDLFECATTLSTFNNLQYLTYMVSGPPATIAQEALLAVKWAAACPTLRTIILPRGKVWYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4JT27</accession>
    <name>W4JT27_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_480863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551572.1">
        <property type="nucleotide sequence ID" value="XM_009553277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JT27"/>
    <dbReference type="GeneID" id="20677937"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_480863"/>
    <dbReference type="HOGENOM" id="CLU_044614_3_3_1"/>
    <dbReference type="InParanoid" id="W4JT27"/>
    <dbReference type="OrthoDB" id="3186354at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="359" mass="38971" checksum="465AE0339EFDE309" modified="2014-03-19" version="1">MPTVEMKLPPLDQMFLVGIWIETLLYGACVILVFATAVRILLKKRSTGTFSIFLLSASSFLFIISTIYVSVCLRQLLEAFIWGPPGQATLYFANEPYKLSILKLVLYNVNVCTQDLILIWRLWVVWGRKWMMVVLPLTLEAIRFSSNLVAIVRGAHPNIPIFDPIIHRWSIVTWSMDLTINVGVTLLLAYRLFMFGRAVPTPHGRNNTYASIIYTVVESGLLFSAATIVVVALYLSGSSAVVAALDVTVQIATISPLLIVVRIGLGLTHGQTVASAVYSTTSYGAHSQTQSRTLPPLSAHAPVVQIGGAGARSPLGGPIKVDITRSVDMYTPSGRGYEMEVLNEKGLGSASASEGGSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTI8</accession>
    <name>W4JTI8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="8">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HETIRDRAFT_480993</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="8"/>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551710.1">
        <property type="nucleotide sequence ID" value="XM_009553415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTI8"/>
    <dbReference type="STRING" id="747525.W4JTI8"/>
    <dbReference type="GeneID" id="20677950"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_480993"/>
    <dbReference type="eggNOG" id="KOG0940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002173_0_0_1"/>
    <dbReference type="InParanoid" id="W4JTI8"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08382">
        <property type="entry name" value="C2_Smurf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000079">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E3_ubiq-protein_ligase"/>
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        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
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    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 8 10" id="KW-0833">Ubl conjugation pathway</keyword>
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        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
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        <location>
            <begin position="223"/>
            <end position="256"/>
        </location>
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    <feature type="domain" description="WW" evidence="13">
        <location>
            <begin position="293"/>
            <end position="326"/>
        </location>
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    <feature type="domain" description="WW" evidence="13">
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            <begin position="347"/>
            <end position="380"/>
        </location>
    </feature>
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        <location>
            <begin position="437"/>
            <end position="770"/>
        </location>
    </feature>
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        <location>
            <begin position="140"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
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            <begin position="267"/>
            <end position="289"/>
        </location>
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            <end position="171"/>
        </location>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR001569"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETW76843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="770" mass="86793" checksum="57252C27DED23252" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVQ3</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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            <taxon>Bondarzewiaceae</taxon>
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            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
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    </dbReference>
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        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
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            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="684" mass="76796" checksum="84A6C167057F6AFE" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4JW11</accession>
    <name>W4JW11_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_326449</name>
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            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
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            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Stahlberg J."/>
                <person name="Velez H."/>
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                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="ETW77066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="42370" checksum="2F63D538DF9DD518" modified="2014-03-19" version="1">MPNQYKPLSPEDELEPWIKLYYHLGLTDIQIAELTLENFDREVFGLGSIWTRVKQKWFSACKKKWGLKSTQQQAHTIETIAVHVAEIKRCFPNRGLTPLPRPSELRTTSAFLGKKFSLPDICEVSTSFWHRALVAKYLTLTEPEAVKKHRHQKFKRHMFWAAGLNSIWAMDQHNKFIHWMKIWWTNQNPRLIASFYIETACCEKGIPLIMQSDPGSENFGVANAHTLWMRKYQNIKPESHWSILLLFRWLAIPWLQCKLDAWVYQRNMTAHHANRHKILPHGIPELICQQPHHYDSIDFKVVISDALINELEQRWALPAHDVFKLVLDKFVDRIQPLYLNLSEPQVSFDLFWNIFCHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JW74</accession>
    <name>W4JW74_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_441368</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549759.1">
        <property type="nucleotide sequence ID" value="XM_009551464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JW74"/>
    <dbReference type="GeneID" id="20675358"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_441368"/>
    <dbReference type="eggNOG" id="ENOG502R1YP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_980243_0_0_1"/>
    <dbReference type="InParanoid" id="W4JW74"/>
    <dbReference type="OrthoDB" id="3251571at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046528">
        <property type="entry name" value="DUF6593"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20236">
        <property type="entry name" value="DUF6593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6593" evidence="1">
        <location>
            <begin position="23"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="284" mass="30776" checksum="0081AC37E1B57A63" modified="2014-03-19" version="1">MSVPPSGVGPPSYHLKLSSTTVMDTTYVDTATSRPVFATITRAGVTTLYRFGGRDGIEDVGEIRWNGGARGGQLVTLHGQTVPCEDFVRKSKGILGGVSHTFEAARQRCKWKSGETIGFMHETSGYPGMREWHCRLVAQSASSTATALCSPTQSTSDTLLARFVPPQLGLIKSELSIYPAGAAIIDELLLTSIMVAAGKSEWRTRESPSSRTRESLARGRASGLPLYRLQLAPGHQRVRSLPMPMIPFDGDDDPDLPPYRSTLTVNMEGAGVVPYSYSQAIREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWF9</accession>
    <name>W4JWF9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATPase dynein-related AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_156533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550934.1">
        <property type="nucleotide sequence ID" value="XM_009552639.1"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JWF9"/>
    <dbReference type="GeneID" id="20667642"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_156533"/>
    <dbReference type="eggNOG" id="KOG1808">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001400_1_0_1"/>
    <dbReference type="InParanoid" id="W4JWF9"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000587">
        <property type="entry name" value="von Willebrand factor A domain containing 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039891">
        <property type="entry name" value="VWA8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21610">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21610:SF9">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase dynein-related AAA" evidence="2">
        <location>
            <begin position="78"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase dynein-related AAA" evidence="2">
        <location>
            <begin position="782"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1032"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1032"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW77425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1392" mass="154997" checksum="A8002BFC0C12EE84" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWR5</accession>
    <name>W4JWR5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lysophospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_326661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550823.1">
        <property type="nucleotide sequence ID" value="XM_009552528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWR5"/>
    <dbReference type="STRING" id="747525.W4JWR5"/>
    <dbReference type="GeneID" id="20671260"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_326661"/>
    <dbReference type="eggNOG" id="KOG2112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062889_0_0_1"/>
    <dbReference type="InParanoid" id="W4JWR5"/>
    <dbReference type="OrthoDB" id="437457at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="2">
        <location>
            <begin position="43"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW77301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="293" mass="31310" checksum="D62DDC0F8B50AAA7" modified="2014-03-19" version="1">MPDPTDIHVRASADIGAQIRRSPRTKPGPNASALPIPFTYTPSPDGVDENLLVLLHGLGDTHGPFASLGRALNLPQTATLALCASLQLPFLDAPGFQWYPSLTALAEPDPQADPTPAFDLISTVISYLTTECQWPANRVHMFGFAQGGSVAVETVVRWAREAEKGKGKDKEKEGDASAGVGALGSVASVCGSLLSYPTPGMPACPTPLFYFHRPSATRPSAASTLAALRKAFDSVTEASFPVKLTDDEGGEEGEVSMPRTRDEWEPVMRFWGQRLSRRAPADDGDIYEVMTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXA6</accession>
    <name>W4JXA6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha</fullName>
            <ecNumber evidence="4">2.5.1.58</ecNumber>
            <ecNumber evidence="3">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">CAAX farnesyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FTase-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ras proteins prenyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Type I protein geranyl-geranyltransferase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HETIRDRAFT_325323</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="4"/>
    <dbReference type="EC" id="2.5.1.59" evidence="3"/>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550096.1">
        <property type="nucleotide sequence ID" value="XM_009551801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXA6"/>
    <dbReference type="FunCoup" id="W4JXA6">
        <property type="interactions" value="138"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JXA6"/>
    <dbReference type="GeneID" id="20671139"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_325323"/>
    <dbReference type="eggNOG" id="KOG0530">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026582_1_1_1"/>
    <dbReference type="InParanoid" id="W4JXA6"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF1">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE_GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="251"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETW78094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="347" mass="40016" checksum="238FD1EA3058EDAF" modified="2014-03-19" version="1">MVDVTTEQPLLFSERPEWSDVVPIEQYDGVSPLAPIFYSEEYKDAANYFRGIVKTGEMSPRVLDLTERIIRLNPAHYSAWQYRYQTLLATSSSLAAELALTNALTKSFLKTYQVWHHRRLLVTLLNEPAPELPFVENALTVDAKNYHTWSYRQWVLAHFDRAEMWEGEIAFVERMLDKDVRNNSAWHHRFFVLFERGGAKTEEAVRRELVFAKEKIALAPNNASAWNYLRGVLDHTHTPYATQSSFAKLYTVSPEEEDDDDEDERESEEKGSEHDVLDLENPAPSKGAKLPCVAALEFMADVYEAEGKDGLSRAVELWTSLASEHDTIRKKYWEYRIKEATTNVQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYC9</accession>
    <name>W4JYC9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_50280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548772.1">
        <property type="nucleotide sequence ID" value="XM_009550477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYC9"/>
    <dbReference type="GeneID" id="20678137"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_50280"/>
    <dbReference type="eggNOG" id="ENOG502S3G3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_32_0_1"/>
    <dbReference type="InParanoid" id="W4JYC9"/>
    <dbReference type="OrthoDB" id="128646at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="126" mass="14518" checksum="27162836297758B4" modified="2014-03-19" version="1" fragment="single">MNDRIITPIRLNVKVSNRSQYAGAKATIDSACEGVIVNETWVKKHRFPTYTLNNPIRVRNVDDTINKAGLIRSALDVNLTIRDISGRTHTERVQMFISNLGKDDLILGTDWLKYHDPSIEWRRREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZS5</accession>
    <name>W4JZS5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_453511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549261.1">
        <property type="nucleotide sequence ID" value="XM_009550966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZS5"/>
    <dbReference type="GeneID" id="20676394"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_453511"/>
    <dbReference type="HOGENOM" id="CLU_1865385_0_0_1"/>
    <dbReference type="InParanoid" id="W4JZS5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="137" mass="15200" checksum="71079887EF9A5828" modified="2014-03-19" version="1">MSSSRFRASIDAFRLSPAPSAQRFKYSRVAQRRIDGCSALEDQRRLGRACARICARVEYEYELRTFSGRRDAHPWALGRAERHAPGRLATGRKPSGTAVARPAQTSASTNPLETPPRKDNTHAPPRAADAKRKQVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4K021</accession>
    <name>W4K021_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pericentrin/AKAP-450 centrosomal targeting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_477957</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
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        <property type="entry name" value="GCFC_dom"/>
    </dbReference>
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        <property type="entry name" value="STIP/TFIP11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045211">
        <property type="entry name" value="TFP11/STIP/Ntr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329:SF1">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
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            <begin position="257"/>
            <end position="303"/>
        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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    </feature>
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            <end position="351"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW79222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="953" mass="106758" checksum="74624F9ADC7B1C6E" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0U3</accession>
    <name>W4K0U3_HETIT</name>
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        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_321581</name>
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    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
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            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW79448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="210" mass="23860" checksum="CCDD8E1C302E3BFC" modified="2014-03-19" version="1">MSNPASSVFNLRVVGVCLFCSNIQGYEWAMLLDQEVSMIWNSPWNLSKVLYLLSRYTPVLDMSLSIKHVPRNFRCRNRTYALYANSKKILSSLGSLWAIWVSVNIWILVKWMDSLVFAKPPSPLIPGCYIVHADPIVFVSFASLLFHETVIVLLTVRKALQLTRQSESPLLFTLFRDGIIFYVCLLRTSSKGHNSIIPAAFLTKRSASQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4K132</accession>
    <name>W4K132_HETIT</name>
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        <recommendedName>
            <fullName evidence="13">DWNN-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_156028</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
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                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="ETW79050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="FunCoup" id="W4K132">
        <property type="interactions" value="232"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K132"/>
    <dbReference type="GeneID" id="20667615"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_156028"/>
    <dbReference type="eggNOG" id="KOG0314">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019105_2_1_1"/>
    <dbReference type="InParanoid" id="W4K132"/>
    <dbReference type="OrthoDB" id="106784at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E3 ubiquitin-protein ligase RBBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DWNN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033489">
        <property type="entry name" value="RBBP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DWNN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="78"/>
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            <end position="225"/>
        </location>
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            <end position="137"/>
        </location>
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        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
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        </source>
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        </source>
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        <source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="608" mass="66966" checksum="9DF687BF32508AE3" modified="2014-03-19" version="1"> </sequence>
</entry>
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    <accession>W4K144</accession>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
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                <person name="Bouzid O."/>
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                <person name="Cullen D."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Yakovlev I."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
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        </source>
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            <end position="73"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="73" mass="8230" checksum="CC90E576A0B167E6" modified="2014-03-19" version="1">MRKKLLRRSLRISKKSPVRAGSERARTSVPCGARVSCSSKMKDRGGRRRPTNLTATNETTRRPILRPYSSSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4K160</accession>
    <name>W4K160_HETIT</name>
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        <name evidence="11" type="ORF">HETIRDRAFT_171924</name>
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            <taxon>Bondarzewiaceae</taxon>
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            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
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                <person name="Coutinho P.M."/>
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                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
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            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
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        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Cytochrome_P450_fung"/>
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        <property type="entry name" value="CYTOCHROME P450 98A3"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="EP450I"/>
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    </dbReference>
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        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="478"/>
        </location>
        <ligand>
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        </ligand>
        <ligandPart>
            <name>Fe</name>
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    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW79552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="561" mass="63901" checksum="601899166165453D" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1Y4</accession>
    <name>W4K1Y4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_322294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548349.1">
        <property type="nucleotide sequence ID" value="XM_009550054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1Y4"/>
    <dbReference type="GeneID" id="20670835"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_322294"/>
    <dbReference type="HOGENOM" id="CLU_050560_0_0_1"/>
    <dbReference type="InParanoid" id="W4K1Y4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="479" mass="52597" checksum="89A3EF8A3FE69C14" modified="2014-03-19" version="1">MLLHDDHDASSPSRNSSPDVVLMVANPDVERVERGTSPHRPDAGRIDRGTSPQQPGSTGVLLTPHTNNFSDDDAEDYAKFKERERTRRPSPERASRGAPRHESSDDRNQSSLGPLPVGVPPPSEGTRPSGVAGPSGFRARTAAQLPGHGEAEPIPVLSETAPPPVPTSGPIPSSMGGPTPRTDPHTGELERHADALLQRNTISAVIQMATAMALQRLANFSAGQPGNEHSDVPRRLASASRQIRTLALQTDPDTASWYAHNDGRPRALLIHPDEFSQYVNRELLPALLFGGELGNVQPSRTDPFRVVTWNVPRPGEHPTPVSNPRRVPRTVVERPPPRQREVPTAHSHTATPPSHRIRGFPLSQGNTDEEEPPVYRRNEGRRSRGNQATLGRGTTAGRSIRHRPGSPPPSARFRTNEREDNRSSRRTRRADSEARRNSSWTRSELDAWDALDDPGNYDDADPYYRPDEGGGDYQGPFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4K269</accession>
    <name>W4K269_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
            <ecNumber evidence="7">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_151266</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="7"/>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548433.1">
        <property type="nucleotide sequence ID" value="XM_009550138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K269"/>
    <dbReference type="STRING" id="747525.W4K269"/>
    <dbReference type="GeneID" id="20667383"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_151266"/>
    <dbReference type="eggNOG" id="KOG2499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007082_0_2_1"/>
    <dbReference type="InParanoid" id="W4K269"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06562">
        <property type="entry name" value="GH20_HexA_HexB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF26">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845121" description="Beta-hexosaminidase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="11">
        <location>
            <begin position="22"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="10">
        <location>
            <begin position="177"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001093-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW79897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="553" mass="61177" checksum="9BBF9AC960E45A6B" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2B3</accession>
    <name>W4K2B3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_321624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548473.1">
        <property type="nucleotide sequence ID" value="XM_009550178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2B3"/>
    <dbReference type="GeneID" id="20670772"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_321624"/>
    <dbReference type="HOGENOM" id="CLU_2996741_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2B3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="57" mass="6435" checksum="C2263017AE170615" modified="2014-03-19" version="1">MLRVCHMATMTCKLLSHLCHTTPLCEPQPCHSSARLFPVFISCHLLIKCLPPYVPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2H3</accession>
    <name>W4K2H3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_117293</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548130.1">
        <property type="nucleotide sequence ID" value="XM_009549835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2H3"/>
    <dbReference type="GeneID" id="20666546"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_117293"/>
    <dbReference type="HOGENOM" id="CLU_048769_1_0_1"/>
    <dbReference type="InParanoid" id="W4K2H3"/>
    <dbReference type="OrthoDB" id="3070075at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="45"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW79550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="167" mass="18223" checksum="DA1FAB322F467E27" modified="2014-03-19" version="1">MAVDTVRTTLTDEERNRLRMEGGCFYCRQKGHMANQCPVRGSSRVYEGSTGHVQQGSRTVGNRSAQTSSRMGGGGSGYGRAFSAGTPGSTQGGTTAQGRSMATTNPFRARLAARQAHAPGPDAPVREEEPEISREEIQRVIGKMRWDEQEALLQELSEISKRKESDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2K7</accession>
    <name>W4K2K7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_453737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549531.1">
        <property type="nucleotide sequence ID" value="XM_009551236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2K7"/>
    <dbReference type="FunCoup" id="W4K2K7">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="GeneID" id="20676410"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_453737"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2K7"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="377" mass="41787" checksum="3DA184C6E97B56AF" modified="2014-03-19" version="1">MSSADPKLFHPIRVGNINLQHRIVLAPLTRCRANAEHVHGDYAVDYYSQRASVPGTLLITEATFIAPQAGGNTNVPGIWSDEQVEAWKKVTDAVHVKGSFIYLQLWALGRAADPTILAEEDPSFPYVSSGNIQMTGAPYPPRPLTIAEVKEYVQLYATAASNAVHRAGFDGVEIHNGNGYLPDQFLQDTANNRTDEYGGSIENRARFSLEVVDAVAKAVGEKVVGIRFSPWAPFQDMRMADPIPTFSHLITAIRDRHPEFGYVHLVEPRISGDGDSHVGHPHDLESNDIFRALWGPRPYLTAGGYNRSSAIKVAEEKGGLIVFGRHFLANPDLPLRLRKDLPLTPYHRETFYHPRNSPIGYTDYPFTKEEPQIAGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4K362</accession>
    <name>W4K362_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_419215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548089.1">
        <property type="nucleotide sequence ID" value="XM_009549794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K362"/>
    <dbReference type="GeneID" id="20673544"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_419215"/>
    <dbReference type="eggNOG" id="ENOG502SQ8R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094288_0_0_1"/>
    <dbReference type="InParanoid" id="W4K362"/>
    <dbReference type="OrthoDB" id="3133596at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="258" mass="29927" checksum="A508C6015F6A516B" modified="2014-03-19" version="1">MSFMNAIGTIILCRLNQLSRLEWAWGMKYDTIQTDQYSNTISLRHDWRDLLESDRWVLIPSTDIIDKLWDRWVKFPLRDGNIPSIEYMYDGAETFEYRLVPLFPDVPSISCHNKAKDVPEGDESPGTSVHSYPFDYLPPIFSRVKSHFVVCNSGRKIRSMLLEFDRTTSDITCIYVFEEKAECVKLVVYATYCAWNNHVHPAMFVISPRIIDSRSRSSLIRTGQMNCASQAICPKKLLEVSPPALYLRYSIFRTSLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3T2</accession>
    <name>W4K3T2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HbrB-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_476087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009548918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3T2"/>
    <dbReference type="STRING" id="747525.W4K3T2"/>
    <dbReference type="GeneID" id="20677660"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_476087"/>
    <dbReference type="eggNOG" id="ENOG502RZ40">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016137_1_0_1"/>
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    <dbReference type="OrthoDB" id="2290221at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013745">
        <property type="entry name" value="Bit61/PRR5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428:SF2">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="432"/>
        </location>
    </feature>
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        <location>
            <begin position="166"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
    </feature>
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    </feature>
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            <end position="400"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW80467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="47470" checksum="5542256F85C54155" modified="2014-03-19" version="1">MHRLGNFAHLPSALAPSLSTGPSSSSLSLANSSAPAPSILSTSSTENPWGTLHVLVLPLFNGEPLRIPIEDLNTLVKRHIASIVSNSPPKAIATLEAEASELIGSGMDTLNGKLAGIEDDKLVGRVVELWGFFWDQVLPYVEGVLLPLQTDPILSSLYRTPKTHRNSSPTRQNGKGSMSMPSHLLPSTAQIDVRTVALRSFRDKIILPIYTRLHARLSSQKQESFSEGHTYPRLQQMLLVLVSQGRRQMTSLSLTEPASQPPAGEAAVTHLLRLVRSTTSGTRIGSAHTNPHQARTLSFLSSNIPRDRRGRIAHRPNPLRADVSEEDEDEDDIDEDEDGAETPRLGFASARERYRGREFLEALRSPDRPGVRQSGGWGLGAFNEDGKEKADEDDEDEQPDWDNLQADVERMVGMKSTTSGGPPLPERRRRMT</sequence>
</entry>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3Z3"/>
    <dbReference type="GeneID" id="20671792"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_35488"/>
    <dbReference type="eggNOG" id="KOG3375">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068528_1_0_1"/>
    <dbReference type="InParanoid" id="W4K3Z3"/>
    <dbReference type="OrthoDB" id="21120at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019380">
        <property type="entry name" value="Casein_kinase_sb_PP28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039876">
        <property type="entry name" value="HAP28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22055">
        <property type="entry name" value="28 KDA HEAT- AND ACID-STABLE PHOSPHOPROTEIN PDGF-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10252">
        <property type="entry name" value="PP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Casein kinase substrate phosphoprotein PP28" evidence="2">
        <location>
            <begin position="117"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
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            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
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            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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        </location>
    </feature>
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        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW79771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="206" mass="23747" checksum="BDE1C95F7D552849" modified="2014-03-19" version="1">MVRGSGKFKTKRGGGRSFSRNLELDENGTAVSTDKPRRRRNDPQEEESSEEEEDIEEESSEEESEEDAAGGLALDKPELSRQERRDLKKKQADQKNKKKADGEGSDEDADADELLVNPNRVVKKMNISDLNEPRQLSRREREVKEKQEAKDRYWKLHLEGKTDQAKTDLARLARIRQERETAQAKRKAEAEERTKEIEAKKNAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4K405</accession>
    <name>W4K405_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucose-6-phosphate isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_322918</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009550304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K405"/>
    <dbReference type="STRING" id="747525.W4K405"/>
    <dbReference type="GeneID" id="20670917"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_322918"/>
    <dbReference type="eggNOG" id="KOG2446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2334090_0_0_1"/>
    <dbReference type="InParanoid" id="W4K405"/>
    <dbReference type="OrthoDB" id="5831190at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW80075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="12368" checksum="5CFB88769EBA6C7A" modified="2014-03-19" version="1" fragment="single">YAAWKMLQQLYDTEKDQLVLNNLFAVDPARFSRDYKEHTAVSDSANTLLLDYFKNLIIQPVFATVLDIVREAGGEQVRDKMFTGEHINTSENRGVLHVVLCSFGSLNTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4K547</accession>
    <name>W4K547_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_319807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547623.1">
        <property type="nucleotide sequence ID" value="XM_009549328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K547"/>
    <dbReference type="STRING" id="747525.W4K547"/>
    <dbReference type="GeneID" id="20670625"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_319807"/>
    <dbReference type="eggNOG" id="KOG1674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057371_3_0_1"/>
    <dbReference type="InParanoid" id="W4K547"/>
    <dbReference type="OrthoDB" id="337735at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF117">
        <property type="entry name" value="PHO85 CYCLIN PHO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="28646" checksum="D7125B541DED7E6F" modified="2014-03-19" version="1">MESEGRVGLPPAYEDADVDSLAQLMALMLERLMSINDRIPLSPYVITRFHSASVPNINVLDYLRRVVRFTNIEKTCLLIVMHYIDQICARMPVFTISSLTCHRFLITAVALASKTLCDTFCTNAHYARIGGITTHELGRLEREFLFAIDWRLTCTREVLQLYYENLVSHSGGRFIIIGAQSGGSVSSDSDVEADSPPSRSMSPIEEDSPGLVPGPSTRPHEPSTILIDTATLVPEAPRGPTVEQNMAFEQFQRSLGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5J9</accession>
    <name>W4K5J9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ferrochelatase</fullName>
            <ecNumber evidence="7">4.98.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_385801</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>heme b + 2 H(+) = protoporphyrin IX + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.98.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ferrochelatase family.</text>
    </comment>
    <dbReference type="EC" id="4.98.1.1" evidence="7"/>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547766.1">
        <property type="nucleotide sequence ID" value="XM_009549471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5J9"/>
    <dbReference type="FunCoup" id="W4K5J9">
        <property type="interactions" value="483"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K5J9"/>
    <dbReference type="GeneID" id="20672255"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_385801"/>
    <dbReference type="eggNOG" id="KOG1321">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018884_1_0_1"/>
    <dbReference type="InParanoid" id="W4K5J9"/>
    <dbReference type="OrthoDB" id="1323at2759"/>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1400:FF:000001">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0408">Iron</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW81087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="353" mass="38858" checksum="50D97A46DAAD769E" modified="2014-03-19" version="1">MLNMGGPATVPETHDFLKNLFMDSDLIPLPFQSMIAPWIAKRRTPQIEAQYTAIGGGSPILRYTELQGKSMATLLDELHPETAPHKSYVAFRYTNPLTDDAIKRMKEDGVKRAVAFTQYPQYSCSTTGSSLNEIFRKGKAGDIGDIEWSVIDRWGTHPGFIEAVSQNIEAALQKFPESTRSETVLLFSAHSLPMSVVNRGDPYVLEVSATVSRVMDRLNHSNPYRLVWQSQVGPSAWMGMQTNDAVKGLARLGKKQVVLVPIAFTSDHIETLYELDLEYVKEAKEHGIDAQRAASLNDSPVFIRALADIAAKHLKDYSTGAIGHTSVQMGLRCPGCTNAVCGQQKAWFAGGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5P4</accession>
    <name>W4K5P4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_101801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547399.1">
        <property type="nucleotide sequence ID" value="XM_009549104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5P4"/>
    <dbReference type="GeneID" id="20665798"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_101801"/>
    <dbReference type="HOGENOM" id="CLU_1190043_0_0_1"/>
    <dbReference type="InParanoid" id="W4K5P4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="233" mass="26101" checksum="375C876C36E5F7B2" modified="2014-03-19" version="1">MHVRPITKRSREIRQRQRPKTRLISRAIGHSPHRQVQPSQPNQSTGSELSEPRCGIASGEAEAEALDGQKSTLGVSWDPEDTVWTAGIAGAVQKTDAQTERNHGRTKSGGVGVEPGSMTILTQRNPRDKMARIPAYAIVARGQKTTNRDTLAKYSSASERQRQQRDLPQAAIRPQRRDRYGEITDWEVDRPRVCSRKALERKTRDGASTRDMRGIHDGAALENWTPEHGRQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5W1</accession>
    <name>W4K5W1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_410266</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547857.1">
        <property type="nucleotide sequence ID" value="XM_009549562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5W1"/>
    <dbReference type="GeneID" id="20672847"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_410266"/>
    <dbReference type="eggNOG" id="ENOG502S02V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066046_1_0_1"/>
    <dbReference type="InParanoid" id="W4K5W1"/>
    <dbReference type="OrthoDB" id="10006218at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026913">
        <property type="entry name" value="METTL24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026:SF10">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13383">
        <property type="entry name" value="Methyltransf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844100" description="Methyltransferase domain-containing protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="4">
        <location>
            <begin position="99"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase FkbM" evidence="3">
        <location>
            <begin position="235"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW81192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="42185" checksum="C97B490F684F0C6B" modified="2014-03-19" version="1">MPVRHPRYTFLLAVLVLLVLFLLLLDTSYSYNSFYPAPSSPARTVTTDLGLPARVARAERIYQKMLAKRKGLINKFGPNVKDIVPFPEDREPWPAYTIWDFFPPAFNCPHELERIGALGDGGKWLCGLSRLESKPDCVVYSIGAAAHASFEAELLARTRFCEVWGFDFTVPGFGPEITAPHKSDSDWRAYFAEPVEHFYTADGQEREEGTDAEEGGRKEYWSDRGKSLERRTHFKPWGVAGHDAPATSDKPPIYTIESLMRSNDHAHIDVLKIDAESLEFDVLTAFVAAFSTLPIGQLIVELHVWNRPFDELLKWWEALERAGLRAFMAEPNLIYQNYNRHASPELAEFSFLNVKNTNVFVADASAAPDTARGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4K638</accession>
    <name>W4K638_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase C15, pyroglutamyl peptidase I-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_476485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547499.1">
        <property type="nucleotide sequence ID" value="XM_009549204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K638"/>
    <dbReference type="STRING" id="747525.W4K638"/>
    <dbReference type="GeneID" id="20677690"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_476485"/>
    <dbReference type="eggNOG" id="KOG4755">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043960_1_0_1"/>
    <dbReference type="InParanoid" id="W4K638"/>
    <dbReference type="OrthoDB" id="407146at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="entry name" value="Peptidase C15, pyroglutamyl peptidase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PROTEASE FAMILY C15 PYROGLUTAMYL-PEPTIDASE I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402:SF1">
        <property type="entry name" value="PYROGLUTAMYL-PEPTIDASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW80795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="37045" checksum="BC5549E7E32A6928" modified="2014-03-19" version="1">MPALDPDPDPFASRFHGPIPDIPDDAYRVLLTGFGPFFRYRENPSWLAARPLNNVTFHFDPSPDRMVEDDLPPAANGRGRARLIHITSLQLPVTYQAVLDCGPGFHARPPVLPPSSDPLHPLAPPPEGGYDFIFHLGLAGRGPLRMERLAHKIGYRMKDTAGQHAPIVDYLPDPATLEQSQAEVLEHAARLAAFLGNRVTEGVMDVHGPLDAVQDSPTRGFGKGYESFVDDMFTAIDVEKLVYDLKEQGIDTVYSSMDAGHYVNDFLYYCSLAESRRTATKHDRTKLTRVLFMHCPPAGQPVSTQEVIDAVKKIIFWVCKDEDTIPPVPPLTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4K663</accession>
    <name>W4K663_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 7">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_440489</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role as a glucosyl donor in cellular metabolic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 7"/>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547526.1">
        <property type="nucleotide sequence ID" value="XM_009549231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K663"/>
    <dbReference type="FunCoup" id="W4K663">
        <property type="interactions" value="451"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K663"/>
    <dbReference type="GeneID" id="20675268"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_440489"/>
    <dbReference type="eggNOG" id="KOG2638">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023632_3_0_1"/>
    <dbReference type="InParanoid" id="W4K663"/>
    <dbReference type="OrthoDB" id="932129at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW80825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="503" mass="56838" checksum="CC2A5AD92C187ABB" modified="2014-03-19" version="1">MANLLPRADSFNARTRGSSHIDFKTATTGVAAKAMRNELSRLVGTVQDSKQKKAFDTEMQSFFYLFTRYLTERAQNQDLDWDRIHSPGKDQIVPYASLIKPKDSSNLNKLAVLKVNGGLGTSMGMTGAKSALEVKDDMTFLDLTVRQIEHLNTTHRVDVPLILMTSFNTHDDTLRIIKKYANQQLRITTFNQSRYPRIYKETLLPAPKTADDDKKNWYPPGHGDLYNALLHSGVLDQLIAEGKEYLFVSNSDNLGAVVDQSILQHMIDTQAEYLMEVTDKTKADIKGGTLVDYEGSIRLLEVAQVPSEHVEEFKSIRKFKIFNTNNLWINLKALKHIMDTEGMELEIIINPKVNDDGQAVIQLETAAGAAIKHFRNAHGINVPRSRFLPVKSCSDLLLIKSDIYSLEHGQLVINENRMFETTPVIKLGDHFKKIQQFQKRFKKIPKIIELDHLTVTGDVYFGRNVTLRGTVIVVANEGQRIDIPDGCILENRLLSGNLNMIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4K730</accession>
    <name>W4K730_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA-capping enzyme subunit beta</fullName>
            <ecNumber evidence="8">3.6.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-triphosphate monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_317859</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:67005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the fungal TPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="8"/>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546244.1">
        <property type="nucleotide sequence ID" value="XM_009547949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K730"/>
    <dbReference type="FunCoup" id="W4K730">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K730"/>
    <dbReference type="GeneID" id="20670454"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_317859"/>
    <dbReference type="eggNOG" id="ENOG502RZAX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018004_1_0_1"/>
    <dbReference type="InParanoid" id="W4K730"/>
    <dbReference type="OrthoDB" id="272147at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07470">
        <property type="entry name" value="CYTH-like_mRNA_RTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="entry name" value="mRNA triphosphatase Cet1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040343">
        <property type="entry name" value="Cet1/Ctl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004206">
        <property type="entry name" value="mRNA_triPase_Cet1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118:SF1">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE CTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02940">
        <property type="entry name" value="mRNA_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA triphosphatase Cet1-like" evidence="10">
        <location>
            <begin position="59"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW81613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="340" mass="38386" checksum="7B5866C06947861B" modified="2014-03-19" version="1">MNTRDRARYASGSEQEAEYQRPQKRLRTSPSPDRPNGNGHTSMSLPPLSVSILGVEPLDEFIREVADFVHHMIMTRAPDLQGQVEVEAKIGVLKDKGTGRRIALPVLVETILTPQEIDCRFESNMSASQHKHFNKLLNELRTASSQPGHPSTTLAYDHLRLVDSFYSSEGSGDRDKIRVTRNEKTNEVIECLRKVRLGNLDIYSPKRAADWRISVNVEVPGEYPSIGNDHPLCRAAKTIPVKHPIGTATLKRRKDRMSYSHEEFRIDLTQVTSQAAQSQQPEILHELELEFARPALLLATAAKRNDENVTEHEQSAFDELIRAFVNNARILVRNAGEGWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4K794</accession>
    <name>W4K794_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_427006</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546299.1">
        <property type="nucleotide sequence ID" value="XM_009548004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K794"/>
    <dbReference type="GeneID" id="20674170"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_427006"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001324_5_4_1"/>
    <dbReference type="InParanoid" id="W4K794"/>
    <dbReference type="OrthoDB" id="3353471at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="4">
        <location>
            <begin position="670"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="779"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW81673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1002" mass="113309" checksum="A493FA6365974DC5" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7C6</accession>
    <name>W4K7C6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_104976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546292.1">
        <property type="nucleotide sequence ID" value="XM_009547997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7C6"/>
    <dbReference type="GeneID" id="20666041"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_104976"/>
    <dbReference type="HOGENOM" id="CLU_2109357_0_0_1"/>
    <dbReference type="InParanoid" id="W4K7C6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="115" mass="13145" checksum="D17D8CFA4D35AA92" modified="2014-03-19" version="1">MTWSLYSPPYWSTDIDRNRVGLEASRPLGLLCDTDAKSESDPSPSPLLRSGEFEMGETSQRESRHESETVNAEMETRGVLVTPSQSVVHRRVFSRARIDKRDRFDGRYARAQVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7G7</accession>
    <name>W4K7G7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoglycerate mutase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_25713</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545769.1">
        <property type="nucleotide sequence ID" value="XM_009547474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7G7"/>
    <dbReference type="STRING" id="747525.W4K7G7"/>
    <dbReference type="GeneID" id="20669251"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_25713"/>
    <dbReference type="eggNOG" id="KOG0235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_0_1_1"/>
    <dbReference type="InParanoid" id="W4K7G7"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043456">
        <property type="term" value="P:regulation of pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051695">
        <property type="entry name" value="Phosphoglycerate_Mutase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517:SF1">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2">
        <location>
            <position position="3"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="2"/>
            <end position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW81709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27200" checksum="41AEDF8405D80F15" modified="2014-03-19" version="1" fragment="single">IRHGESTDNLRSVWAGWEDAPLSNHGKQQARAMGQSFTETRFTAIYASTLKRAFTTAQALYDGQKDPKPTFTSSPLLREQHFGIAEGKPWTYHREKGMTLEEQFDQGKFPVLHHDDEKFPGGESLNDLAARANRAIEELVLPHVWTAAKEGEKGVHIALVSHGLCISQLMIQLLKHNTDGPDGGDYRGLKNTAWSRVTVSIKQGLKEGERLESVDDAQSPLDIRVTDIDRHSHIENIVCAPLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7N0</accession>
    <name>W4K7N0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_247666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546426.1">
        <property type="nucleotide sequence ID" value="XM_009548131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7N0"/>
    <dbReference type="GeneID" id="20669195"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_247666"/>
    <dbReference type="eggNOG" id="ENOG502S8XQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083660_2_1_1"/>
    <dbReference type="InParanoid" id="W4K7N0"/>
    <dbReference type="OrthoDB" id="2339190at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW81827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="100" mass="10733" checksum="A8FB5FFD1DE17035" modified="2014-03-19" version="1" fragment="single">IVVSPPITSPTASTVWNVGDKVLVTWDTSDIPEPKNFTGQLLLGFQENDSENLMLDSPLASGFQLIDGQVQITVPDVPPKSDYIVVLFGDSGNASPEFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7U3</accession>
    <name>W4K7U3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl-CoA thioesterase-like N-terminal HotDog domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_125007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546073.1">
        <property type="nucleotide sequence ID" value="XM_009547778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7U3"/>
    <dbReference type="STRING" id="747525.W4K7U3"/>
    <dbReference type="GeneID" id="20666893"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_125007"/>
    <dbReference type="eggNOG" id="ENOG502S4FF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071618_0_0_1"/>
    <dbReference type="InParanoid" id="W4K7U3"/>
    <dbReference type="OrthoDB" id="2532955at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052389">
        <property type="entry name" value="Sec_Metab_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110">
        <property type="entry name" value="CHROMOSOME 23, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110:SF1">
        <property type="entry name" value="THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="1">
        <location>
            <begin position="29"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="321" mass="35059" checksum="E68A05BC087D0A0A" modified="2014-03-19" version="1">MEASKIMNRGSSGSKLRPVTLSALPGRRYVLGLIVEACLRYQSSTSQPDPVHVTAHYLRATSVGPFEVRVRTLRTGKGLANLLADLIQDNVIKVTAHAIFGNLDPASASQTGPSLTLVPPAPGARVTPFGIYPSSLKPSTKEPRWNFTPYIQAARDRSIHERHARLAKAGESDGGVEGGGWYTFSDPGDVLTPASLAFFADLFPDKLPVAAYPDLPSSWFPTVTMSVQFCARIPRGSENHSQHTVGTFTSGRFIDEPMGRHDIYVEVWTAPSDLGDGKQPKEGWREDQRCLVVAHQMALTVPMEVNERKRKPATQDAKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4K869</accession>
    <name>W4K869_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Association with the SNF1 complex (ASC) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_384393</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546534.1">
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_384393"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="531008at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
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    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="ASC_dom"/>
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    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="248"/>
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            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="144"/>
        </location>
    </feature>
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            <begin position="151"/>
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        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW81944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="248" mass="25193" checksum="80FCD83D03AB8BF6" modified="2014-03-19" version="1">MSNLSASISKHTGPPSTPTNGNGAANATSNNAGGFQISFWSESSVGGARAGPPKWTQDLPAELLAAAREEEIYLADGAAGGAPAPNIPPAPVLPRHLDKLILNTRPAAPRSDANARAEERARRTAGASTQAPGHGRVRSRTRHSALGMTEVQGQGQGGSADGEGAIPVTTASGTDVTATAAGRGETGARAGVSLSGPALADDASVLPVPSHVVLHHLSTSAIRNGVLAVGNTTRYKKKFITTIYYKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8X1</accession>
    <name>W4K8X1_HETIT</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_115560</name>
    </gene>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_115560"/>
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    <dbReference type="InParanoid" id="W4K8X1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="199" mass="21479" checksum="230D7B544EBCFD3B" modified="2014-03-19" version="1">MPTALSLALSTLSDSAAPPTLSAILPHYIRFAGYPPTALPKQSGAPLSAAAQITSPIAVAALRAFEHALDKHPASSSLVRDLRRAYWRLRLGADIVPCRCCDAAMAAMVAGDAPPVKLARETERALWAFAEAEEDDRAEMRLRKMRKRRVAVLEPYPFVSAGSPPDGIVLETAMDKLDTYNPIDGQTSDGVARTFIDCF</sequence>
</entry>
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    <accession>W4K9D3</accession>
    <name>W4K9D3_HETIT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_409802</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009548571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9D3"/>
    <dbReference type="GeneID" id="20672808"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_409802"/>
    <dbReference type="HOGENOM" id="CLU_2688124_0_0_1"/>
    <dbReference type="InParanoid" id="W4K9D3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="79" mass="8776" checksum="F7486F3E64E708C2" modified="2014-03-19" version="1">MRARTTPRRQEPAFACDPQPPARPLDPTPVSSSPRSLATECLRLHQPLGPTHPSSPATYIRTRASRQAHARMLEPSTYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9T9</accession>
    <name>W4K9T9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_316510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544875.1">
        <property type="nucleotide sequence ID" value="XM_009546580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9T9"/>
    <dbReference type="GeneID" id="20670338"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_316510"/>
    <dbReference type="HOGENOM" id="CLU_1036455_0_0_1"/>
    <dbReference type="InParanoid" id="W4K9T9"/>
    <dbReference type="OrthoDB" id="2693103at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="269" mass="29304" checksum="ADFAD23D7B48E053" modified="2014-03-19" version="1" fragment="single">DVVHSVHMIPGFAYGHTSELLAHSIARKHEENKPDGNDDKEDPEWMYQNEYDERCEETDYLFYYVGMFSDRDMFMRFRGGGIGHRGTRSVDKYLQQDTYTLDPEDLTEEHEAPLNGPSNTNAATVSAAEADVASNDAHMSTANATATLYVDIPSTEGDADGVADKGGGISDSEDSGMPEDPENISKGKSRETAGKSDTHNDDKDEDEEEDEGEHEGESESGSEDESESESESDDGSGSEDAADEGSESGDTDDEADDEAIRDREGYGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4KA70</accession>
    <name>W4KA70_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aspartic peptidase DDI1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_57882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544685.1">
        <property type="nucleotide sequence ID" value="XM_009546390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KA70"/>
    <dbReference type="STRING" id="747525.W4KA70"/>
    <dbReference type="GeneID" id="20678414"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_57882"/>
    <dbReference type="eggNOG" id="ENOG502SRIE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003921_0_0_1"/>
    <dbReference type="InParanoid" id="W4KA70"/>
    <dbReference type="OrthoDB" id="3252634at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="30449" checksum="B67C53047183DA34" modified="2014-03-19" version="1">MGAPAKIPLAKKDAPAYETTAPIYDEKVAAEVYNRAMATQVTLTQRELLSLSAEVRSQVREATSARRSPARDASNVRTFYQDADLPYAIDDLEPPTRPTVSSFVNVLHQPETPPPGAIIIPDMYEMYLKNLQPGQVPQPLIVAKESSALRSIIPLVDHQQEVECVVDPGSQVIAMSEGICNELALIYDPEIVLNMQSANGEIDRSLGLARNVPFLIGDITLYLQVHIIRNPAYDVLLGRPFDILTESIVKNYSNEDQTITISDPNTGRRATIPTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KA83</accession>
    <name>W4KA83_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450 monooxygenase 57</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">cyp57</name>
        <name evidence="12" type="ORF">HETIRDRAFT_68311</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544706.1">
        <property type="nucleotide sequence ID" value="XM_009546411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KA83"/>
    <dbReference type="STRING" id="747525.W4KA83"/>
    <dbReference type="GeneID" id="20678852"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_68311"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_3_1"/>
    <dbReference type="InParanoid" id="W4KA83"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW82654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="516" mass="58257" checksum="A9DF7C79DA19AC85" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KA84</accession>
    <name>W4KA84_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_451819</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546795.1">
        <property type="nucleotide sequence ID" value="XM_009548500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KA84"/>
    <dbReference type="FunCoup" id="W4KA84">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KA84"/>
    <dbReference type="GeneID" id="20676199"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_451819"/>
    <dbReference type="eggNOG" id="KOG3275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_3_0_1"/>
    <dbReference type="InParanoid" id="W4KA84"/>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="12"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="100"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW82260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="142" mass="15601" checksum="2D79E904F4A069B4" modified="2014-03-19" version="1">MASSARNLASCIFCKIIKGEIPSYKLVETDLSFSFLDIGPLSKGHALIIPKYHAAKLHEMPDEYLADALPIAKKIVNALGAENYNILQNNGRIAHQVVDHVHFHVIPKPSESDAEGLVIGWPTSSPPKEEVAKLHEELLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W4KB08</accession>
    <name>W4KB08_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methionine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_458559</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="3"/>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545266.1">
        <property type="nucleotide sequence ID" value="XM_009546971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KB08"/>
    <dbReference type="FunCoup" id="W4KB08">
        <property type="interactions" value="495"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KB08"/>
    <dbReference type="GeneID" id="20676924"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_458559"/>
    <dbReference type="eggNOG" id="KOG1247">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009710_3_2_1"/>
    <dbReference type="InParanoid" id="W4KB08"/>
    <dbReference type="OrthoDB" id="5844513at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.20:FF:000001">
        <property type="entry name" value="Methionine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000037">
        <property type="entry name" value="Methionyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="entry name" value="Methionyl-tRNA synthetase, Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000738">
        <property type="entry name" value="WHEP-TRS_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="Methionyl-tRNA synthetase (MetRS), Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51185">
        <property type="entry name" value="WHEP_TRS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WHEP-TRS" evidence="13">
        <location>
            <begin position="648"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW82973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="699" mass="78058" checksum="6CDC72157E1214A8" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBN7</accession>
    <name>W4KBN7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_426147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544841.1">
        <property type="nucleotide sequence ID" value="XM_009546546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBN7"/>
    <dbReference type="GeneID" id="20674083"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_426147"/>
    <dbReference type="HOGENOM" id="CLU_132424_0_0_1"/>
    <dbReference type="InParanoid" id="W4KBN7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="102" mass="11566" checksum="34453C564188449C" modified="2014-03-19" version="1">MPNNVQARHRLSLDSQQKMMKIRRGIILTSAQVPEEPSDEAVDEQGGAEDNDSEEEYEEEKGEEGPLMEEEEDSDDDLDPLPKGDGRERDERVLAEEGYGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCA9</accession>
    <name>W4KCA9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HETIRDRAFT_316471</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 19">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545268.1">
        <property type="nucleotide sequence ID" value="XM_009546973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCA9"/>
    <dbReference type="FunCoup" id="W4KCA9">
        <property type="interactions" value="269"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KCA9"/>
    <dbReference type="GeneID" id="20670335"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_316471"/>
    <dbReference type="eggNOG" id="KOG2108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004585_4_1_1"/>
    <dbReference type="InParanoid" id="W4KCA9"/>
    <dbReference type="OrthoDB" id="1470711at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17932">
        <property type="entry name" value="DEXQc_UvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001201">
        <property type="entry name" value="ATP-dependent DNA helicase UvrD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.486.10">
        <property type="entry name" value="PCRA, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF2">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE SRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="15">
        <location>
            <begin position="8"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="16">
        <location>
            <begin position="304"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="802"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="802"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="813"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="860"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="29"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETW82975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="936" mass="103502" checksum="D1C05427B692629F" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCE6</accession>
    <name>W4KCE6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_474540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545657.1">
        <property type="nucleotide sequence ID" value="XM_009547362.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCE6"/>
    <dbReference type="GeneID" id="20677571"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_474540"/>
    <dbReference type="HOGENOM" id="CLU_2654787_0_0_1"/>
    <dbReference type="InParanoid" id="W4KCE6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW83404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="76" mass="8916" checksum="25CCE85D41FA3123" modified="2014-03-19" version="1" fragment="single">MCYIGPRERMLHCILYFYHCIDYSIRSELDQSRIPSFCPSLGYLSCDLLCVIPACMLRYIDLGLLYRICRSLVGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCF7</accession>
    <name>W4KCF7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Uridine kinase</fullName>
            <ecNumber evidence="11">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HETIRDRAFT_157190</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>cytidine + ATP = CMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>uridine + ATP = UMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UPRTase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the uridine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="11"/>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545314.1">
        <property type="nucleotide sequence ID" value="XM_009547019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCF7"/>
    <dbReference type="FunCoup" id="W4KCF7">
        <property type="interactions" value="489"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KCF7"/>
    <dbReference type="GeneID" id="20667705"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_157190"/>
    <dbReference type="eggNOG" id="KOG4203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021278_0_3_1"/>
    <dbReference type="InParanoid" id="W4KCF7"/>
    <dbReference type="OrthoDB" id="738517at2759"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00579">
        <property type="reaction ID" value="UER00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043771">
        <property type="term" value="F:cytidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044211">
        <property type="term" value="P:CTP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000023">
        <property type="entry name" value="Probable uracil phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002070">
        <property type="entry name" value="Uridine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004018">
        <property type="entry name" value="PRK05480.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00235">
        <property type="entry name" value="udk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="13">
        <location>
            <begin position="66"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="14">
        <location>
            <begin position="303"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETW83025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="534" mass="59577" checksum="73F6F5D4B0F1DC27" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCG2</accession>
    <name>W4KCG2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_163436</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545319.1">
        <property type="nucleotide sequence ID" value="XM_009547024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCG2"/>
    <dbReference type="STRING" id="747525.W4KCG2"/>
    <dbReference type="GeneID" id="20667845"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_163436"/>
    <dbReference type="eggNOG" id="KOG1287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013661_0_0_1"/>
    <dbReference type="InParanoid" id="W4KCG2"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF353">
        <property type="entry name" value="METHIONINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW83030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="550" mass="59459" checksum="634C9644F0E232CC" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCL9</accession>
    <name>W4KCL9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_47514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543213.1">
        <property type="nucleotide sequence ID" value="XM_009544918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCL9"/>
    <dbReference type="GeneID" id="20677605"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_47514"/>
    <dbReference type="HOGENOM" id="CLU_2910295_0_0_1"/>
    <dbReference type="InParanoid" id="W4KCL9"/>
    <dbReference type="OrthoDB" id="6512771at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW83528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="62" mass="6371" checksum="BB53C9CB9675B6EB" modified="2014-03-19" version="1" fragment="single">AHAYATRCYAGPCLLCSIPLVCPCRCGATTHNVPCSAVGGAAPAPEILCDRPYGALRACARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCZ5</accession>
    <name>W4KCZ5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_438795</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543484.1">
        <property type="nucleotide sequence ID" value="XM_009545189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCZ5"/>
    <dbReference type="STRING" id="747525.W4KCZ5"/>
    <dbReference type="GeneID" id="20675078"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_438795"/>
    <dbReference type="eggNOG" id="KOG1717">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027074_11_7_1"/>
    <dbReference type="InParanoid" id="W4KCZ5"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF511">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="86"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW83727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="172" mass="19656" checksum="E07A0D46B52BE63D" modified="2014-03-19" version="1">MGWKNVSAVIEGRLFLGNLVSAQSTRSLTERRITHIVSVCTDPIPAEHPQSGIRHIRIPVQDFDHEDLLIWMPHACRFIDEALRAGGVVLVHGVYGLSRSATIMASYLMYSRRISSTDALDTVRRAREQIWPKAGFLEQLSMFEMCRYAPSMNEGIYVRWRQHMDRRLQGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4KD77</accession>
    <name>W4KD77_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_380979</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gemin-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543505.1">
        <property type="nucleotide sequence ID" value="XM_009545210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KD77"/>
    <dbReference type="GeneID" id="20672046"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_380979"/>
    <dbReference type="eggNOG" id="ENOG502SCAA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061593_0_0_1"/>
    <dbReference type="InParanoid" id="W4KD77"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035426">
        <property type="entry name" value="Gemin2/Brr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794:SF0">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794">
        <property type="entry name" value="GEMIN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04938">
        <property type="entry name" value="SIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW83753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="401" mass="44806" checksum="BF9C6420001C7B28" modified="2014-03-19" version="1">MSSGFKRKRDDADEDDEPAYGLRQILPVANLPSNFEGEPEDGMQYLFTVRRETRQLPAVKRAPNPYETAPPEPALPSASTFIASTIAPSPPSQKSHIPSEQWRSTFTRRFVNFRKNTSQPTIHVYMPMPRARGQKLMPDKKERDRWWEFFAGSPASVWDPPRAAKQPKQREVRRLGNDDHAVPPFHRTNAYGSSTDEWVVGTVTEEQLAEMHDGTRVSDTDPRQGAFASGSLQASTGNMSGANDGVSELQSASSPSPPLVPREPTPTLLQYIDHRMSVHLLMYFTHWFNLHLEWLDSASTAPPAHIPTESHARWIFTLLGRVDAFCTADEISGLRGLARVCLGLVRARRERGDGDVKGKSTEAHRGMGEVACWMVVCIVVGMWGQQDLWSDAEEMLSKVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4KD89</accession>
    <name>W4KD89_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidylethanolamine binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_170176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543477.1">
        <property type="nucleotide sequence ID" value="XM_009545182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KD89"/>
    <dbReference type="STRING" id="747525.W4KD89"/>
    <dbReference type="GeneID" id="20668268"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_170176"/>
    <dbReference type="eggNOG" id="KOG3346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043994_1_0_1"/>
    <dbReference type="InParanoid" id="W4KD89"/>
    <dbReference type="OrthoDB" id="275748at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845311" evidence="2">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW83719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="299" mass="30897" checksum="81542A71BF4031F6" modified="2014-03-19" version="1">MLSYFAILAFSCWIRPGGAQVDAASLSTVKSAFETSKVVPDVIPSFDPTALLDVVFVDPFTNDTVHVTPGMELTANREFRILMPAARGLCCSANEPLAETANKPQFFVSFSDNSVAEQTFVLAMVDPDAPTPQNRSLSQIRHFLAGDIKVAGGSSNHSQLVNASVPLTAYLNPSPPAGSDAHRYTILLFPQPDNFDHTALDLVNASVDASRLSFNLTTFASSVGMGSPLAGTFFLTKGPTADSTTSGTAAASNPASAVAPSASGGTGNGNANGAGASRDFNGVALAVAVIVGILSIAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDA6</accession>
    <name>W4KDA6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_472133</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543568.1">
        <property type="nucleotide sequence ID" value="XM_009545273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDA6"/>
    <dbReference type="FunCoup" id="W4KDA6">
        <property type="interactions" value="323"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KDA6"/>
    <dbReference type="GeneID" id="20677439"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_472133"/>
    <dbReference type="eggNOG" id="ENOG502RZ3Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070319_2_0_1"/>
    <dbReference type="InParanoid" id="W4KDA6"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03141">
        <property type="entry name" value="GATase1_Hsp31_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="6">
        <location>
            <begin position="84"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW83827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="226" mass="24161" checksum="577B616A028FB193" modified="2014-03-19" version="1">MSQSRILFVYTSADKTLRGHQTGWYLPEAAHPYHVLAPHFPIDFASPAGPNPPIDQGSIEMFKDEQSVKFLEDPAVKALLANAKPLKDVNVDEYIAIFYVGGHGPVLDLATDHANIELANKFYRSGKIVSAVCHGPAALVGVTGADGKSIFDGKAATCLTNVEEEQVDKVKDIPFLVEDRIVSLGGKFEKAEPWGVKVVQSGTLLTGQNPASAGPLGEAILKALKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDW6</accession>
    <name>W4KDW6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <ecNumber evidence="3 11">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_449546</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="3 11"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543666.1">
        <property type="nucleotide sequence ID" value="XM_009545371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDW6"/>
    <dbReference type="FunCoup" id="W4KDW6">
        <property type="interactions" value="322"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KDW6"/>
    <dbReference type="GeneID" id="20675960"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_449546"/>
    <dbReference type="eggNOG" id="KOG0563">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013524_2_3_1"/>
    <dbReference type="InParanoid" id="W4KDW6"/>
    <dbReference type="OrthoDB" id="60984at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000015">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000111">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 11" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="6 11" id="KW-0521">NADP</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="12">
        <location>
            <begin position="26"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="13">
        <location>
            <begin position="209"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW83939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="512" mass="57862" checksum="8CFA0A826AB4BA8B" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KE30</accession>
    <name>W4KE30_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-mannosidase B</fullName>
            <ecNumber evidence="3">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mannanase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_62676</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="3"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543269.1">
        <property type="nucleotide sequence ID" value="XM_009544974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KE30"/>
    <dbReference type="STRING" id="747525.W4KE30"/>
    <dbReference type="GeneID" id="20678611"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_62676"/>
    <dbReference type="eggNOG" id="KOG2230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005015_1_1_1"/>
    <dbReference type="InParanoid" id="W4KE30"/>
    <dbReference type="OrthoDB" id="2866996at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000050">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="11">
        <location>
            <begin position="24"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="9">
        <location>
            <begin position="196"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="10">
        <location>
            <begin position="687"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW84009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="860" mass="98175" checksum="9A71FAECBD114D75" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KE81</accession>
    <name>W4KE81_HETIT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_119480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545618.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KE81"/>
    <dbReference type="STRING" id="747525.W4KE81"/>
    <dbReference type="GeneID" id="20666653"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_119480"/>
    <dbReference type="eggNOG" id="ENOG502SBYH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_303655_0_0_1"/>
    <dbReference type="InParanoid" id="W4KE81"/>
    <dbReference type="OrthoDB" id="2246127at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912:SF34">
        <property type="entry name" value="NOTOCHORD-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="980" mass="109821" checksum="C41F3B7D983F9D3B" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEC1</accession>
    <name>W4KEC1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_439012</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GnRH family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543802.1">
        <property type="nucleotide sequence ID" value="XM_009545507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEC1"/>
    <dbReference type="GeneID" id="20675094"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_439012"/>
    <dbReference type="eggNOG" id="ENOG502SD56">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061858_0_0_1"/>
    <dbReference type="InParanoid" id="W4KEC1"/>
    <dbReference type="OrthoDB" id="2502001at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002012">
        <property type="entry name" value="GnRH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00473">
        <property type="entry name" value="GNRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844190" description="Thioredoxin domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="296"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="305"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW84089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="38242" checksum="8072C28066F143E6" modified="2014-03-19" version="1">MRLSALLLAVGCAAPLGASAQYFSQGWKPGQAAPAPSSTPHAFDPSTAPAAAAPPQKAKADYGLSSILTDFVSSGPIASLLDRAGINVTERLSAAQQDIWDERIPLITDENYKEIIVNEVFETEQEEKDRVWFLIISVTTAQPQGVSKYADEQFDAAFNLTQIENDLPNVRWGRIDYINVTTITTKWNVWQAPMLVVLKDRGQTLRFWRATQLRLKPDSLREFLRTEHFERTAPWKSNFGPGGSREFVLDYLAIAMAVMYDYTRRLPRWALYMFTGAFGSLVIGFVHRGDTKKLAAKEKAEAQKQQETANNATSIAPPPSAVSTSVSPASGTPKKTSAKGKKGKKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KF11</accession>
    <name>W4KF11_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_408428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543983.1">
        <property type="nucleotide sequence ID" value="XM_009545688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KF11"/>
    <dbReference type="GeneID" id="20672681"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_408428"/>
    <dbReference type="HOGENOM" id="CLU_1768321_0_0_1"/>
    <dbReference type="InParanoid" id="W4KF11"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="147" mass="15816" checksum="F1645B0768BB5901" modified="2014-03-19" version="1">MPSQPYTHIPPPPPLPPQPLQLISVPSSRQSYLPPASPSSSALSPSSSTPSTQGHLRATSGRHSLPLPQPPSGVPQQQPIYQPIPPPPLLVSNSHIQYQTPRPPVQQSHGFYPGPPPRPPAQITGPIGRSQWLPSGEMRTYEQQGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KF13</accession>
    <name>W4KF13_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_47466</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Yakovlev I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <end position="146"/>
        </location>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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        </location>
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            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="216" mass="24425" checksum="FBA22ED4027E36F1" modified="2014-03-19" version="1">MKFDNRLSWPPSILPDSAHHTMSYYVQSTPRHRSHSLSAYPSPMPTYSTSPYGHNTTGQYYHPPTPGGYAAYGGGTPQRYNSVGGSYRGASYAVPSTTHHIPTSHTRSAHGPAYYVAPSTHHHSTHRGRHHSHRRSQSTSSHRRHATPVYADSGRHHNYHHSSSKHYRPHISLADRIRNFFGIGHHSNHRSHSRTRFTDARTGREVDTRGRPIIAY</sequence>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
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                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
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                <person name="Velez H."/>
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                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW84518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
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    </evidence>
    <sequence length="77" mass="8538" checksum="1567F6A9A5697E9D" modified="2014-03-19" version="1">MCRRCSACCCTGRAGGAAPARRCTYTLVLEATHARWEAPLHIGLRGRTKPSGEGGFCRTPHRWDGRFDTDLRLVPHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Cullen D."/>
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                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
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                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
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                <person name="Yakovlev I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
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    <dbReference type="STRING" id="747525.W4KFZ7"/>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
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                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
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                <person name="Yakovlev I."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
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</entry>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Hansson D."/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMP_N"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Creatinase/aminopeptidase"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROLINE_PEPTIDASE"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="70"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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    </feature>
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            <begin position="8"/>
            <end position="23"/>
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    </feature>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
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        <source>
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        <source>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KH51</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">HETIRDRAFT_407337</name>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_407337"/>
    <dbReference type="HOGENOM" id="CLU_485757_0_0_1"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="340"/>
            <end position="363"/>
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            <begin position="195"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="561" mass="61080" checksum="AB8FF51031A93AAC" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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            <taxon>Heterobasidion</taxon>
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    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="GeneID" id="20668151"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_168367"/>
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    <dbReference type="Proteomes" id="UP000030671">
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
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        <location>
            <begin position="50"/>
            <end position="95"/>
        </location>
    </feature>
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            <begin position="211"/>
            <end position="235"/>
        </location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="285" mass="30236" checksum="8473337D0F7328F2" modified="2014-03-19" version="1">MLQDRLRQGCLPLASLNLAEEMLQRYSFILVLILSFYIVMAKKGSEHLESSTSEAPSSTSHTAMDGSNPSTTSTITVASSLSASPTSASPSPTSSNSPYLYFDSPANTTTCNDTTFSWKFEGQTSVPLTIQITNSLSVQIAIAPGYSRAMVSFRTLTTDVPSTAAELEWSPVDVDEGSYTAVAFDTSRAAGIFAQSSPFFVASGNNRTCLANSSSTSSPSNTSSPSSSSRSSTGKHLSRGALAGTIAGLASGVIILFLAFSVPRLLRHHLPTRRNRRPGGPYYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
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                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Velez H."/>
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                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="InParanoid" id="W4KHZ8"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="90" mass="9884" checksum="D23B3BF59324A637" modified="2014-03-19" version="1">MQLLPETVTESPAGGIQRQSGTREDTFHGPTHGVGIVTVDQMGERRTSPIENPPNTSALKNGKRYYTISSRGETWTTLASDRYGTRGRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIH5</accession>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">TC 32-1</strain>
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    </reference>
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    <dbReference type="FunCoup" id="W4KIH5">
        <property type="interactions" value="34"/>
    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_309932"/>
    <dbReference type="eggNOG" id="ENOG502S81F">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016340">
        <property type="entry name" value="Ribosomal_mL60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L31, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09784">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="11887" checksum="257934EDB4A6C37B" modified="2014-03-19" version="1">MFGAFRATSPVNVGLLWKVPWRLSSTRKANVRTRLKKVDAVIEAVRASGVECSALTSALELPKEHEMDPKDKYTVFTPHARGYRKGIHKVPKFTRITHRVNPKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJ56</accession>
    <name>W4KJ56_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_438488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542687.1">
        <property type="nucleotide sequence ID" value="XM_009544392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJ56"/>
    <dbReference type="STRING" id="747525.W4KJ56"/>
    <dbReference type="GeneID" id="20675051"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_438488"/>
    <dbReference type="eggNOG" id="ENOG502S6PS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_5_2_1"/>
    <dbReference type="InParanoid" id="W4KJ56"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="36603" checksum="6681BC89DA33F459" modified="2014-03-19" version="1">MCARCAPSDVLFVDPADHDQFFRDVHGRRCNSLNDRYLFPADEEELKRFELSHRMLQFVLEGKNYVGPVERVLSPAGRGDDSEELQVLDLGTGGGLWAIDMADEFPHVQVTGVDLAPMQPRLVPPNCTFELCDLDRYCLPYPSNSYDVVHARYMHTGIHNYPLFLHELTRILRPGGVLILIESDLRPIADGKPALSPAKSGIPGWCALADAFRRALARRGVDATVPERMAHMLSDLFGAHYDVVRQQQADIPIGFWPKDPTLLAVGQLAWMNWDLLLLATRPLLLSSGIPEWQVKSLIEEAQRDLYHPLVHIASRLYVVHAIKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJV8</accession>
    <name>W4KJV8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_308679</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542907.1">
        <property type="nucleotide sequence ID" value="XM_009544612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJV8"/>
    <dbReference type="FunCoup" id="W4KJV8">
        <property type="interactions" value="388"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KJV8"/>
    <dbReference type="GeneID" id="20669607"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_308679"/>
    <dbReference type="eggNOG" id="KOG1465">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_4_3_1"/>
    <dbReference type="InParanoid" id="W4KJV8"/>
    <dbReference type="OrthoDB" id="269919at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000008">
        <property type="entry name" value="Translation initiation factor 2B, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW86137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="369" mass="40578" checksum="CBA945AC8DEEC906" modified="2014-03-19" version="1">MASDLHNAASQRAVETLAAKLRRRQVVGSRETALETVLVLRQVVSKARFQNIQQLVEIIGGVGRKLVEAQPKEHTVGNTVRKMLHHLREEYNNASKGTVASSSTFSISKFVLQGQPRKHLTTQKTESTLVLRENDPDDPDSFARTFKPVLMEAIQDILDELDTVYDNISKSAKDHIHSDEIILTIGKSSTVEAFLKSAAHYHNYTVIVAESGPSYGGHDMARSLSSSGISTFLVSDSSIYALMSRVNKVILGAHAILANGGMFAITGSSLAASAARAHSTPVVVCAGQFKLTPLWNLYHEYGALDFADPSSVLGYEEGDLVDKVDVINPYYDYVRPELVDVYITNDGDHPPPSIYRLIKESYDDEDNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKB4</accession>
    <name>W4KKB4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_100841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542363.1">
        <property type="nucleotide sequence ID" value="XM_009544068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKB4"/>
    <dbReference type="GeneID" id="20665712"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_100841"/>
    <dbReference type="HOGENOM" id="CLU_844827_0_0_1"/>
    <dbReference type="InParanoid" id="W4KKB4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="329" mass="34399" checksum="BE589D1092CA0BB0" modified="2014-03-19" version="1">MSLRRAPKKPDDPGIPNTGKGFRVGRMGYVIAGEASGGPFPLTRASKKPDNPEMPNAGKGFRVGRTGYVIDGEASTGLGGPLHLGRAPKKSDNPGMPNTVKSFRVGRMGYVIAGEASGGPFPLTRASKKPDNPGMPNAGKGFRVGRRGHEIAAPMHKNAATEGIYALNQGTDAGTAEPRDEASVAPSLDGGSLYSLSRSGLPFAPASATHSDCNPSGLALYELESDPLKYQTSEKLLDSFLNSGSGSGSGSGPGSAWLWLSRGHRLQCSSLAPAVDGHTLCPERPDSAQPSNSDTRKKSQNTQKASRPLTPPENDNERTRTAALLDLPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKJ3</accession>
    <name>W4KKJ3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Dihydroxyacetone kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_122126</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542995.1">
        <property type="nucleotide sequence ID" value="XM_009544700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKJ3"/>
    <dbReference type="STRING" id="747525.W4KKJ3"/>
    <dbReference type="GeneID" id="20666771"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_122126"/>
    <dbReference type="eggNOG" id="KOG2426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017054_6_0_1"/>
    <dbReference type="InParanoid" id="W4KKJ3"/>
    <dbReference type="OrthoDB" id="1724672at2759"/>
    <dbReference type="UniPathway" id="UPA00617">
        <property type="reaction ID" value="UER00669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019588">
        <property type="term" value="P:anaerobic glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.340:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF14">
        <property type="entry name" value="DIHYDROXYACETONE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="12">
        <location>
            <begin position="9"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="11">
        <location>
            <begin position="446"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW86239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="652" mass="68442" checksum="E7249A3E0FB23522" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLE0</accession>
    <name>W4KLE0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_447338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540645.1">
        <property type="nucleotide sequence ID" value="XM_009542350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLE0"/>
    <dbReference type="GeneID" id="20675764"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_447338"/>
    <dbReference type="HOGENOM" id="CLU_1267035_0_0_1"/>
    <dbReference type="InParanoid" id="W4KLE0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="218" mass="24161" checksum="D216AFA054680113" modified="2014-03-19" version="1">MPALPARSRITPSPIHHVAIAPGARHRSLHNPRAHAFVNPGSRPPRLVHRTHHMRTAVAGGRVSRICPPYMSPVYVSSRLLAPQRRRQREPPRIISKHGNLGGTPAAHPRRPPVPSPPPPLLQRTRPRAHSPKHTLQHTPCSAHTRPNHEPRLRPPDHAPPMTRPRPIPDVPRRTRDSASLTSPNPASPNASRHTGRHAADTRPTHKFPVKTPDVAHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLW0</accession>
    <name>W4KLW0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_310923</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542834.1">
        <property type="nucleotide sequence ID" value="XM_009544539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLW0"/>
    <dbReference type="FunCoup" id="W4KLW0">
        <property type="interactions" value="562"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KLW0"/>
    <dbReference type="GeneID" id="20669816"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_310923"/>
    <dbReference type="eggNOG" id="KOG1541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055194_0_2_1"/>
    <dbReference type="InParanoid" id="W4KLW0"/>
    <dbReference type="OrthoDB" id="2877at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000017">
        <property type="entry name" value="probable 18S rRNA (Guanine-N(7))-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022238">
        <property type="entry name" value="Bud23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12589">
        <property type="entry name" value="WBS_methylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="10">
        <location>
            <begin position="54"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal" evidence="11">
        <location>
            <begin position="202"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="219"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW86051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="287" mass="31990" checksum="4D67D46F45383C2F" modified="2014-03-19" version="1">MSRPELQAPPEIYYGDTEAKKYTNNTRVQQIQADMTYRALELLNLPPDEPAFLLDIGCGSGLSGEILDEEGYIWTGVDIAPSMLEIALEREVEGDLFLQDIGQGFGFRPGSFDGAISISVIQWLLNAETSHPTSSPPHRLTRFFTTLHSALRNPSRAVLQFYPTSDDQVQLITSIAQKAGFGGGVVVDYPNSKKARKVFLCLFVGGGGASQVPKGLDVGDGVGEEDDSKAKFEKRRQREMKRAKSGKTKKVLGKEWILKKKELYRRRGKEDVPRDSKYTGRKRKTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4KM60</accession>
    <name>W4KM60_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_30556</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540277.1">
        <property type="nucleotide sequence ID" value="XM_009541982.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="W4KM60">
        <property type="interactions" value="141"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KM60"/>
    <dbReference type="GeneID" id="20669336"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_30556"/>
    <dbReference type="eggNOG" id="KOG3613">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001197_0_0_1"/>
    <dbReference type="InParanoid" id="W4KM60"/>
    <dbReference type="OrthoDB" id="297643at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056457">
        <property type="entry name" value="DOP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056458">
        <property type="entry name" value="TPR_DOP1_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24598">
        <property type="entry name" value="DOP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24597">
        <property type="entry name" value="TPR_DOP1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like middle TPR" evidence="8">
        <location>
            <begin position="253"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like C-terminal" evidence="9">
        <location>
            <begin position="1145"/>
            <end position="1611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW86774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1636" mass="183691" checksum="1E6E9FAF0E73D534" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMA7</accession>
    <name>W4KMA7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_310651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542957.1">
        <property type="nucleotide sequence ID" value="XM_009544662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMA7"/>
    <dbReference type="GeneID" id="20669794"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_310651"/>
    <dbReference type="eggNOG" id="ENOG502SG7S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078271_0_0_1"/>
    <dbReference type="InParanoid" id="W4KMA7"/>
    <dbReference type="OrthoDB" id="3365310at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="242" mass="26209" checksum="B429C808055A308E" modified="2014-03-19" version="1">MSLFSSFTTKYRFHLASSSTVSAAGLLYALSQGTRRQSTSAGSSKFILREPPRTAPRQVPTPLAFVSASTWDKESDRGMTALSSMFAEKGFMCMEIDLSSPRQDGTQRSSTELMAHFEKELASHLRFGTVAPGPFPPIIFSRSHGALITQTYISSHPASGLILMSPPPSNASAEGSLLPTPLKEFDYEVKFPVAVVGTKGELERIKTVGRLGSDAVDIIEVESLDGQEAFVKIDTLLDDWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMK9</accession>
    <name>W4KMK9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_99475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541022.1">
        <property type="nucleotide sequence ID" value="XM_009542727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMK9"/>
    <dbReference type="GeneID" id="20678905"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_99475"/>
    <dbReference type="HOGENOM" id="CLU_1180347_0_0_1"/>
    <dbReference type="InParanoid" id="W4KMK9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="235" mass="25929" checksum="90B553D91057C8A6" modified="2014-03-19" version="1">MPSFDTVRSQIHASATRRARAEAPVLAFSSLRVLRAEHDKPLSHTIPDLASGEARSRLLVARSILSFGRSDSPSSYPRGPFTAPPSLSHRRTRHVIGISFWAQSTDIRRRVCIRIAPTRSVRARIQRAQTLPTLTWEGLVPIPAAPVCVPAFHFRKTRPRRDLGTAGTAARFAPSQTHLFAPNSQRPIMPPSFANFVIHGASLSWHHSLAPTLTGSMMYNGSRNLREALFASQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMQ1</accession>
    <name>W4KMQ1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">diacylglycerol cholinephosphotransferase</fullName>
            <ecNumber evidence="9">2.7.8.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pis1</name>
        <name evidence="13" type="ORF">HETIRDRAFT_121281</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>CDP-N,N-dimethylethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33775"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:65117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:33776"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.2" evidence="9"/>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540662.1">
        <property type="nucleotide sequence ID" value="XM_009542367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMQ1"/>
    <dbReference type="FunCoup" id="W4KMQ1">
        <property type="interactions" value="286"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KMQ1"/>
    <dbReference type="GeneID" id="20666743"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_121281"/>
    <dbReference type="eggNOG" id="KOG2877">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035066_5_2_1"/>
    <dbReference type="InParanoid" id="W4KMQ1"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004142">
        <property type="term" value="F:diacylglycerol cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000012">
        <property type="entry name" value="sn-1,2-diacylglycerol cholinephosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW86660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="421" mass="47323" checksum="9F98195E4451DFAE" modified="2014-03-19" version="1">MSYIPQHALANLRNYSYKGVDKSLLSNYVLNPYWTWLVTLWPTWVAPNMITLSGLSIVIINFLTLLYYDPTYLAQKGGASVPQWVYYTWGAGLFLYQSFDAIDGKQARRTGMAGPLGEMFDHGCDALNTTLEVILASHALNLGRSWWTVAAQVATLANFYLTTWEEYYTGQLYLGVFSGPVEGIIMIVAIYILTGIYGPTFWDNKILTFTGLDQVDAIASRVPNIALNELFMVFGTLGMAFNIATSYVNVFRSRRASHGSVFKPLWYLLPFPLSVAAQVLWMNHPKFTNSDILRSPAFVPFLCAWGLQFAHQVGRMILAHVTGQPFPWWDSMWVWSVIGAVDANLPWLIGRPPIIQSSPENTEKFVYVTLAIAFLSYSRFVVLVINDITNYLGIACLTVRKKDARGVWRQAGPQASSEKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMX8</accession>
    <name>W4KMX8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_145360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541128.1">
        <property type="nucleotide sequence ID" value="XM_009542833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMX8"/>
    <dbReference type="GeneID" id="20667076"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_145360"/>
    <dbReference type="HOGENOM" id="CLU_2399934_0_0_1"/>
    <dbReference type="InParanoid" id="W4KMX8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="93" mass="10573" checksum="B4452806778788A0" modified="2014-03-19" version="1">MQLCCPFSTVDQEYPLMEVGLALPKGEIFELEHLVPYPARSRRCLLLNLFLLILSAVRVSFVSTFFFFIDPFLVCRPLSSLSPLSAQIILHNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMZ3</accession>
    <name>W4KMZ3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_469062</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541143.1">
        <property type="nucleotide sequence ID" value="XM_009542848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMZ3"/>
    <dbReference type="STRING" id="747525.W4KMZ3"/>
    <dbReference type="GeneID" id="20677276"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_469062"/>
    <dbReference type="eggNOG" id="KOG3508">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011610_0_0_1"/>
    <dbReference type="InParanoid" id="W4KMZ3"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05137">
        <property type="entry name" value="RasGAP_CLA2_BUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="73"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="268"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="601"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="726"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="637"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="661"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="726"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="749"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW87213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="762" mass="86111" checksum="B05B5AB0C612D098" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNC5</accession>
    <name>W4KNC5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">60S ribosomal protein L13a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_308123</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541219.1">
        <property type="nucleotide sequence ID" value="XM_009542924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNC5"/>
    <dbReference type="FunCoup" id="W4KNC5">
        <property type="interactions" value="302"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KNC5"/>
    <dbReference type="GeneID" id="20669547"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_308123"/>
    <dbReference type="eggNOG" id="KOG3204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076922_0_0_1"/>
    <dbReference type="InParanoid" id="W4KNC5"/>
    <dbReference type="OrthoDB" id="1882297at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3250:FF:000001">
        <property type="entry name" value="60S ribosomal protein L13a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_uL13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW87302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22718" checksum="CB7020987312D1BE" modified="2014-03-19" version="1">MATLSSSPIVIDGKGHLLGRLASIISKQILSGQKITVVRCEEINISGSFFRNKLRYHNFLHKRHIVNPKKSGPFHHRAPSKILFRAIRGMVPHKTARGAAALERLKLFEGVPPPYDRKKRMVVPEALRVLRLKPGRKYCTVKRLSHEVGWGYKDVVDHLEEKRKIKAQAFHERKLAAVKLRQKAISDTASSFEQLTALGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4KP38</accession>
    <name>W4KP38_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_407176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541467.1">
        <property type="nucleotide sequence ID" value="XM_009543172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KP38"/>
    <dbReference type="STRING" id="747525.W4KP38"/>
    <dbReference type="GeneID" id="20672576"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_407176"/>
    <dbReference type="eggNOG" id="KOG1018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036590_8_2_1"/>
    <dbReference type="InParanoid" id="W4KP38"/>
    <dbReference type="OrthoDB" id="252265at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF162">
        <property type="entry name" value="RIBOFLAVIN BIOSYNTHESIS PROTEIN PYRD, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18785">
        <property type="entry name" value="Inv-AAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="171" mass="17806" checksum="4D6BD99DB55BA4A5" modified="2014-03-19" version="1">MALPDEHVRHLRRALAQAHKCTPSPSAFCVGCVLVVRGVVLATGHSRELPGNTHAEANALANARALSPAALAALFPAAPPPASADDLLRAADVYTTLEPCSVRTSGLAPCADALIAARVRRCFVGVGEPDDFVKCEGAQRLIDAGIEVVWVKGLEDECLAAARRGHDSPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4KP44</accession>
    <name>W4KP44_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear protein localization protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HETIRDRAFT_121918</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NPL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541472.1">
        <property type="nucleotide sequence ID" value="XM_009543177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KP44"/>
    <dbReference type="FunCoup" id="W4KP44">
        <property type="interactions" value="747"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KP44"/>
    <dbReference type="GeneID" id="20666760"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_121918"/>
    <dbReference type="eggNOG" id="KOG2834">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017172_1_0_1"/>
    <dbReference type="InParanoid" id="W4KP44"/>
    <dbReference type="OrthoDB" id="10251089at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08061">
        <property type="entry name" value="MPN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000243">
        <property type="entry name" value="Nuclear protein localization protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016563">
        <property type="entry name" value="Npl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007717">
        <property type="entry name" value="NPL4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024682">
        <property type="entry name" value="Npl4_Ub-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007716">
        <property type="entry name" value="NPL4_Zn-bd_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710:SF0">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05021">
        <property type="entry name" value="NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11543">
        <property type="entry name" value="UN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05020">
        <property type="entry name" value="zf-NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010052">
        <property type="entry name" value="Polyub_prc_Npl4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0811">Translocation</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MPN" evidence="16">
        <location>
            <begin position="237"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="592"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="600"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETW87587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="660" mass="72572" checksum="76B3ED3C4B551D1F" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4KQ84</accession>
    <name>W4KQ84_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_307416</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541146.1">
        <property type="nucleotide sequence ID" value="XM_009542851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KQ84"/>
    <dbReference type="STRING" id="747525.W4KQ84"/>
    <dbReference type="GeneID" id="20669489"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_307416"/>
    <dbReference type="eggNOG" id="ENOG502S13M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095018_1_1_1"/>
    <dbReference type="InParanoid" id="W4KQ84"/>
    <dbReference type="OrthoDB" id="5546837at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36460">
        <property type="entry name" value="UPF0132 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G10255)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36460:SF1">
        <property type="entry name" value="UPF0132 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G10255)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW87216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="172" mass="18959" checksum="C762D390A5F2F577" modified="2014-03-19" version="1" fragment="single">PPPDEPQPSSSRITRPWLPAPPPSQQATSYQSGGVPTWNTSMAGGAGAAEESEEQQSQWETRYNTRVDVLSAFAYILGPLSALFLLITETKNDYVRFHAYQSALLTTPLLLLRVMTSLLGLPSSLRTLFTLLLVAPASFMAYQAYKGAAQDGLYRFHIPSIGQLAEQWLQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4JM64</accession>
    <name>W4JM64_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_39939</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553046.1">
        <property type="nucleotide sequence ID" value="XM_009554751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JM64"/>
    <dbReference type="STRING" id="747525.W4JM64"/>
    <dbReference type="GeneID" id="20672506"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_39939"/>
    <dbReference type="eggNOG" id="ENOG502RKCK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008737_0_0_1"/>
    <dbReference type="InParanoid" id="W4JM64"/>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="272"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="104"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="165"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="212"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW74618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="725" mass="76580" checksum="76D101A712CBEADB" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMV6</accession>
    <name>W4JMV6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_46171</name>
        <name evidence="1" type="ORF">HETIRDRAFT_57367</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540367.1">
        <property type="nucleotide sequence ID" value="XM_009542072.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553066.1">
        <property type="nucleotide sequence ID" value="XM_009554771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JMV6"/>
    <dbReference type="GeneID" id="20677179"/>
    <dbReference type="GeneID" id="20678394"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_46171"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_57367"/>
    <dbReference type="eggNOG" id="ENOG502RWGT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179474_1_0_1"/>
    <dbReference type="OrthoDB" id="5599163at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW74863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="100" mass="11125" checksum="8FD2C64789BDABF4" modified="2014-03-19" version="1" fragment="single">MLSLFSSFVPGSLHSTNIADPVAIFAAKRKYKPVAQKTRPVLADLPEQFRIVRNILGDPLAALPTLTPNPPPFTPTGRYTAERRDLIDKVHSDDFLWPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPA6</accession>
    <name>W4JPA6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_430720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552726.1">
        <property type="nucleotide sequence ID" value="XM_009554431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPA6"/>
    <dbReference type="GeneID" id="20674475"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_430720"/>
    <dbReference type="HOGENOM" id="CLU_120096_0_0_1"/>
    <dbReference type="InParanoid" id="W4JPA6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844873" evidence="2">
        <location>
            <begin position="24"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW75294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="192" mass="19046" checksum="8F157350F67B3B8C" modified="2014-03-19" version="1">MFSLVKLTTFVALAFGAIASVSAAPQPAAAVQVKRQSDAITAILADLTAELAPAAAQLNSLNAHTATAENITPIVNSIVSSVQNSQSKISALPAQDTSAISANDIASGLNSVFQTVLVPAGNVIALPGVDSATVVPALSPLGGALDGLLTIVLGLVAELLVVVKATLDTLLSGLVHVLVGLNLTGLLASLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRK3</accession>
    <name>W4JRK3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_106689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552314.1">
        <property type="nucleotide sequence ID" value="XM_009554019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRK3"/>
    <dbReference type="STRING" id="747525.W4JRK3"/>
    <dbReference type="GeneID" id="20666184"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_106689"/>
    <dbReference type="eggNOG" id="KOG3341">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2158762_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRK3"/>
    <dbReference type="OrthoDB" id="283883at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016689">
        <property type="entry name" value="ESCRT-2_cplx_Snf8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806">
        <property type="entry name" value="EAP30 SUBUNIT OF ELL COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806:SF0">
        <property type="entry name" value="VACUOLAR-SORTING PROTEIN SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="111" mass="12364" checksum="84B185E372A50775" modified="2014-03-19" version="1">MTDTFDLGQIHPSLFSRSATLCAFVQPTSSLTLAVTIPSSDTVSAVLRRGLHHLSQSQLDNLHTQLAQFRAALTHFATHRRADIQRDPRFRHAFQQMCTTIGVDPLAGPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRU6</accession>
    <name>W4JRU6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_148361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552403.1">
        <property type="nucleotide sequence ID" value="XM_009554108.1"/>
    </dbReference>
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            <begin position="12"/>
            <end position="31"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
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        </source>
    </evidence>
    <sequence length="321" mass="35768" checksum="6C8B6C9F7F248EDA" modified="2014-03-19" version="1">MAATNDGSGMGATYGSLLIGTILSGIFYGITSLQSIHYFNGYADRDQWKMKTLVSVLLLIDTIVMVLHFHAAYHYFVVAFGDASALEGQIMTWSFQLESVFTGVVTFLCQMFFVIRIRKLHRGLYPDSTFAPWLFSSLTLLAVVAFVTSLVLSIILFLNPLWLTLETERLQELMIANIVFATVLDVFITIALCVILERHRSGFKSTDSLINGLMRFMITRGIITTVIQGATLVTYLALPSTFIWLIFHLSTSKIYANAVLTTLTSRTPPRVVNNKDTEIPGDTWNERDPNACVTSTTISFQAQPDMLSCTTVALEDSRIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRV6</accession>
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            <fullName evidence="5">Carbohydrate-binding module family 19 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">HETIRDRAFT_481330</name>
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            <taxon>Basidiomycota</taxon>
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            <taxon>Heterobasidion</taxon>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">TC 32-1</strain>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
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            <taxon>Bondarzewiaceae</taxon>
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            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
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                <person name="Karlsson M."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
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                <person name="Yakovlev I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">TC 32-1</strain>
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    <dbReference type="GO" id="GO:0005634">
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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            <end position="1369"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="875"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="899"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1053"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1077"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1088"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1133"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1181"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1378"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1397"/>
            <end position="1413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW75626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1419" mass="156839" checksum="8ED05532E2394595" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSK9</accession>
    <name>W4JSK9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_23707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551836.1">
        <property type="nucleotide sequence ID" value="XM_009553541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSK9"/>
    <dbReference type="STRING" id="747525.W4JSK9"/>
    <dbReference type="GeneID" id="20668767"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_23707"/>
    <dbReference type="eggNOG" id="KOG4313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048013_0_1_1"/>
    <dbReference type="InParanoid" id="W4JSK9"/>
    <dbReference type="OrthoDB" id="10261522at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031804">
        <property type="entry name" value="DUF4743"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15916">
        <property type="entry name" value="DUF4743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="134"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="317" mass="35311" checksum="CE9913DB3A7927CA" modified="2014-03-19" version="1" fragment="single">QEPVIPFFLSAPTEGQTAQPTGFLRPEVMQRLQHDHSILLRGSGNSPWLLGNSEGMQFVSFSPAVNRDGKQSRTFYINQLVAEWRKQGLFQDILRGWSNEDFPIYHYTPVSNHSPEAVNDPVAFSIERAALPLFGFANFGCLLTAYYRSPDTGKTMFWIPRRSKTKRTWPGRLDVTVGGGMSTGDTASATIIRECAEEASLDANFVQENLRPAGVLPFPNRSPAGWILPGLYYLFDLPLPSDGSVRPKVNTADGEVEEFELMDAQTVLDNLVTGVFKPSSALALVDFLIRHGFVTEETDPRFVDICLQLRQPMSLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4JST8</accession>
    <name>W4JST8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_162925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552381.1">
        <property type="nucleotide sequence ID" value="XM_009554086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JST8"/>
    <dbReference type="GeneID" id="20667809"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_162925"/>
    <dbReference type="HOGENOM" id="CLU_2705105_0_0_1"/>
    <dbReference type="InParanoid" id="W4JST8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004843795" description="Secreted protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="8026" checksum="2D81353F14A20BEF" modified="2014-03-19" version="1">MVMCCTCISLYTMVISMQLALTFDSSRKIVSSNVSDICDNRSASLEGTLTVERAYLTNNAVPLITPLRVSTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTJ9</accession>
    <name>W4JTJ9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl-CoA N-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_106263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551747.1">
        <property type="nucleotide sequence ID" value="XM_009553452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTJ9"/>
    <dbReference type="STRING" id="747525.W4JTJ9"/>
    <dbReference type="GeneID" id="20666147"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_106263"/>
    <dbReference type="HOGENOM" id="CLU_1384331_0_0_1"/>
    <dbReference type="InParanoid" id="W4JTJ9"/>
    <dbReference type="OrthoDB" id="61113at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="22115" checksum="62B6BB2784507365" modified="2014-03-19" version="1">MPRSVVSRIEDPSNDNLEEIVDLLAYTNTDQWVNSMVGGDQTLLPEMFRAMVRAALLDGEVHVVEDGIDETGRAEVCSVGRWFGTYRKCWDTEAQRALGFDKFLGHVSPRSKKSLKEVYSFSYNELFYQVLRKEKEGSCWAMAMDAIHGQKGFGRAIVDTMYQKAIADNMVITGGTSGQEYVRLRIGLTDTQPANSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2024-01-24" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTP6</accession>
    <name>W4JTP6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_156814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551683.1">
        <property type="nucleotide sequence ID" value="XM_009553388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTP6"/>
    <dbReference type="STRING" id="747525.W4JTP6"/>
    <dbReference type="GeneID" id="20667671"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_156814"/>
    <dbReference type="HOGENOM" id="CLU_983723_0_0_1"/>
    <dbReference type="InParanoid" id="W4JTP6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004843878" evidence="2">
        <location>
            <begin position="21"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW76814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="283" mass="27492" checksum="E5A516BB492AAAAE" modified="2014-03-19" version="1">MQNFISLALAFSAFSSGGASAPNLAHRQIFSSFEATAPATTELFPTVSSGISLGAPMTSPIAPVGITSASVVTIQSSAGPIESSATAVTFSSVATIESSASASVVSASTSAHGVTLTSAATSASPIESSSVVTVATSSPGVTFTSVASGPTSCVAYTTITVVVTSTTAVTITASAPSATFTTVPVASSSSAVTSGSSSRRVTRTTVTSVESSSAGTTSPTSAPTESSSASAVTIRSSAPGVTFTSVVTVESASTAHIHSGTTKAITSPIESSDAPVFTSTLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTU7</accession>
    <name>W4JTU7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_421198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW76978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550536.1">
        <property type="nucleotide sequence ID" value="XM_009552241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTU7"/>
    <dbReference type="GeneID" id="20673708"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_421198"/>
    <dbReference type="HOGENOM" id="CLU_2638364_0_0_1"/>
    <dbReference type="InParanoid" id="W4JTU7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="77" mass="7632" checksum="A3DA177983ED7A50" modified="2014-03-19" version="1">MADASTATRPSRAAAGGADWAAAGSGPLGGPRACSRPTMSSRAAQAPPALPPRPSTGWARTRSMLMLGRACTALAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVE6</accession>
    <name>W4JVE6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_51982</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550483.1">
        <property type="nucleotide sequence ID" value="XM_009552188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JVE6"/>
    <dbReference type="GeneID" id="20678199"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_51982"/>
    <dbReference type="eggNOG" id="ENOG502SI5I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1528747_0_0_1"/>
    <dbReference type="InParanoid" id="W4JVE6"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Wax synthase" evidence="5">
        <location>
            <begin position="60"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW77548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="176" mass="19577" checksum="3F248B8B1882D450" modified="2014-03-19" version="1" fragment="single">LEPLFSLQGPEARSITSQGPLLLYVNIVAYMCTPYGMMNMQHSLILAVNVALGISHASAWPDPYGSRVDAYTVRNFWGKTWHQMMRRYISFIGRFFSSLFRFQRGTPLSSYTQLYIGFIVSGIMHTAGGDAMVGYKYLGASLPSFLVRPLAITLEDLVIASASKAGFQSTRLAKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWB3</accession>
    <name>W4JWB3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_420654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549849.1">
        <property type="nucleotide sequence ID" value="XM_009551554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWB3"/>
    <dbReference type="GeneID" id="20673666"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_420654"/>
    <dbReference type="HOGENOM" id="CLU_1199956_0_0_1"/>
    <dbReference type="InParanoid" id="W4JWB3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW77827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="231" mass="25146" checksum="FA46CCF3F7858698" modified="2014-03-19" version="1">MTWIPLDSPCAHRTNTDMVVLGNLPEVTAADGSWTAIVSIVTFLVGWAGIHLNNLSLMTVHTFICVISLNAILGLPMKLPSTPLPSPTALDIRPHSELSRRFSFLESMMTSASLTVDQRRCSPTLSLPNALPSGPCKTEKTLPPHLRVPMPMATLETDRSNRLSRMEPGLGLVLDLLPIKVVSPPPSLRAHTQLPHHRHTRFPPLTRTPPVRTGPAALPRIPNPPFCSSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWD3</accession>
    <name>W4JWD3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_325330</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549890.1">
        <property type="nucleotide sequence ID" value="XM_009551595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWD3"/>
    <dbReference type="GeneID" id="20671140"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_325330"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004645_1_0_1"/>
    <dbReference type="InParanoid" id="W4JWD3"/>
    <dbReference type="OrthoDB" id="446925at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="9">
        <location>
            <begin position="330"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW77873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="473" mass="54064" checksum="AFFCAFD0E7EB61CA" modified="2014-03-19" version="1" fragment="single">GSAANVILAVDTSQIAVGFHLCQCALDNPRVRYYARFGSITLNDRESRFSQPKLELYGLFRALRSLKMYLIGVRNLIVEVDARYIKGMLTNPDLEPSASINRWIVSILTFHFTLVHVPGTSHGPDGLSRRPPQPSDRPEPEDDFDDWIDNLYGFLHQINNTFPTSISTSTTTIFTSSLIGNLPTDTESDDEGPTIDYSDIPRSQKALEAEERLWLVRDWHRTLVRPPSLSDSEYATFLRYCTEFFIAADKLWRKDSHGRHKIVAAPSSRITILTAAHDDVAHKGFYATTALIAERFWWPHMRQDISWFVRTCHLCQIRQTRNVLIPPTVATPAPLFAKMYMDTMHMPTAGGFKYLLQGRCSVSHYPEFRMLRRETSSALADWIFEDILCRWGTLVEIVSDNGPAFVKALDQLAKKYHVRHIRISGYNSRANGIAERPHFDVQQALFKAVDGDQAKWNCAAHFVFWADRITVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWX7</accession>
    <name>W4JWX7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_239899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551073.1">
        <property type="nucleotide sequence ID" value="XM_009552778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWX7"/>
    <dbReference type="GeneID" id="20668839"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_239899"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_6_1"/>
    <dbReference type="InParanoid" id="W4JWX7"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="30947" checksum="E7AF7AA4E1448575" modified="2014-03-19" version="1" fragment="single">IPDLHGKVAVVTGANSGIGYQTTAQLALHGAKVYLACRTESKALAAIARIEKENPILKGTENLIWTPLDLSSISSAKAAAEEILAKEQRLDLLVNNAGFLPAEYSVTEDGMERTVSATANTPGADVRVVIISSVSYKSAGEVNFDTLECFNDKRSIGGTWFARFAQYGQSKLMNILFAMELQRRFDNEGVPIIVSSLHPGGVDTEGAEANAPYVIKILIRLLAMSPLEGAYTSLFAATSAEVVAQPHKYKGKYLERCQVVTPTTKDASDPVLARKLWEATEKVVAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWY0</accession>
    <name>W4JWY0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Clp1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_37249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550471.1">
        <property type="nucleotide sequence ID" value="XM_009552176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWY0"/>
    <dbReference type="GeneID" id="20671849"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_37249"/>
    <dbReference type="eggNOG" id="ENOG502SCZS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059618_0_0_1"/>
    <dbReference type="InParanoid" id="W4JWY0"/>
    <dbReference type="OrthoDB" id="2570975at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="40554" checksum="3743831566CA44CD" modified="2014-03-19" version="1">MVLHHSNSQNRRVSQAENAPPTRLGVVSTIKNHASRQRAMRRANNAPPQPAVAARRLRSRPRTSVQFEFPLPIHLVPPPVASSIDVEMAPPVPGPTKTLVKLPRYLYHPERKEPRPEVVEASVPDLEGVPLQYARDKLPLLSGDMFKVLTGAKIAPPMGALPKEIEVSINDVTSDMPTHVLALYCPLIRPDPNAAVAPKRRITLYPIHSTVFAVHCASLPPLPPSHPEPVPIGGTITVPVLPIGLPSPSAFPFLSHYLYHRRPDKLIASLIPCPPPVAIPIADDASVEEKRNAEKEIIKAYAMKCAAMLTPHALLDRTLLVNGLWRDAYVLGVFDEGLWGSLDLAWEILVNAMAISSGDPDSVQVCLPEWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWZ1</accession>
    <name>W4JWZ1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_411248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550079.1">
        <property type="nucleotide sequence ID" value="XM_009551784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWZ1"/>
    <dbReference type="GeneID" id="20672936"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_411248"/>
    <dbReference type="HOGENOM" id="CLU_2922879_0_0_1"/>
    <dbReference type="InParanoid" id="W4JWZ1"/>
    <dbReference type="OrthoDB" id="66510at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="61" mass="6565" checksum="A5660EE57751083D" modified="2014-03-19" version="1">MVGYGGQNRSTRPLDIGIDVRHIAEGSDSTAGLCEEQNEEPREVGGEVDGLIYANEDAEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXN5</accession>
    <name>W4JXN5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_326002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550306.1">
        <property type="nucleotide sequence ID" value="XM_009552011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXN5"/>
    <dbReference type="GeneID" id="20671197"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_326002"/>
    <dbReference type="HOGENOM" id="CLU_485758_0_0_1"/>
    <dbReference type="InParanoid" id="W4JXN5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="554" mass="61899" checksum="63B8AF2F3C7688D7" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4JY49</accession>
    <name>W4JY49_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HETIRDRAFT_67389</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549682.1">
        <property type="nucleotide sequence ID" value="XM_009551387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JY49"/>
    <dbReference type="FunCoup" id="W4JY49">
        <property type="interactions" value="741"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JY49"/>
    <dbReference type="GeneID" id="20678808"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_67389"/>
    <dbReference type="eggNOG" id="KOG0326">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_30_0_1"/>
    <dbReference type="InParanoid" id="W4JY49"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
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    </dbReference>
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    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="10" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
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            <begin position="72"/>
            <end position="242"/>
        </location>
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            <end position="412"/>
        </location>
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        </location>
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            <end position="454"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="487" mass="54454" checksum="556ECF852B38805E" modified="2014-03-19" version="1">MSQQARPSSSSSPNDNWRAGLRPPPRDDRPQTEDVMATKGLEFEDMFLRRELLMGIFEAGFEKPSPIQEEAIPMALTKRDILARAKNGTGKTAAFVIPSLQQIDINKNKIQALLLVPTRELALQTSQVCKILGKHMGIQVMVTTGGTTLKDDILRLSETVHVLVGTPGRILDLTGKNVADLSECPVFVMDEADKLLSPEFSPVMEQLLAYLPKDRQVMLFSATFPLIVKDFKDKHMNSPHEINLMDELTLRGVTQYYAFVEERQKVHCLNTLFSKLQINQSIIFCNSTNRVELLAKKVTELGYSCFYSHAKMLQSHRNRVFHDFRNGVCRNLVCSDLLTRGIDIQAVNVVINFDFPKNSETYLHRIGRSGRFGHLGLAINLVTYEDRFNLYKIEQELGTEIQPIPHQIDKGLYVAPSAVEEPTGQKPSRSTQSEQQSQSQLQQPQSQLQPPRSQATNGTAQPAGGARPYPTGAPAGAYRGQVPVAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4JY88</accession>
    <name>W4JY88_HETIT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_164040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
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                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="61" mass="6932" checksum="C8BD31BAB7DBF413" modified="2014-03-19" version="1">MEGQSARSRHRPSFLTILWPTNFGLRFAPVSVSRNQPPLLGLCASLGGEWGMFATFRRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYB2</accession>
    <name>W4JYB2_HETIT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_103967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
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                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
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                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
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                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="747525.W4JYB2"/>
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    <dbReference type="OrthoDB" id="3070390at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="140"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="201" mass="22996" checksum="45ADFD7904B0834D" modified="2014-03-19" version="1">MLANLREELEALKQALTKERALRETVSQNLSETSQALKDKSRALEDMSERCTRAEERERLLVIELNRQQDQMAKLEISQATQTDVHSREIEMLKETQKTVLNRLNGIGPHASQDIFVALDSVEYQIADSATKLHATEAVLNNEADDRHLAEQQLKQEQRRHARIIRDIEKEMKDPFVVPALLSAFVNLSDLTERAIQSGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYZ4</accession>
    <name>W4JYZ4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_478054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549083.1">
        <property type="nucleotide sequence ID" value="XM_009550788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYZ4"/>
    <dbReference type="GeneID" id="20677798"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_478054"/>
    <dbReference type="HOGENOM" id="CLU_2015565_0_0_1"/>
    <dbReference type="InParanoid" id="W4JYZ4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="123" mass="13451" checksum="DEEE333BDFA4CD4C" modified="2014-03-19" version="1">MRSTGTRVKTYQGPQGPLLVRALFIPRSTPRLFFCTMRSSSAVLPSQSLTWPTVVERSTPSSISTGKVLPGFSLPFCHPRQWMDSRPAGGKQRPPTSPTPASLQNRPRTLSTPRRPCGCLVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZB4</accession>
    <name>W4JZB4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_20153</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548727.1">
        <property type="nucleotide sequence ID" value="XM_009550432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZB4"/>
    <dbReference type="STRING" id="747525.W4JZB4"/>
    <dbReference type="GeneID" id="20668635"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_20153"/>
    <dbReference type="eggNOG" id="ENOG502RYE1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007340_4_1_1"/>
    <dbReference type="InParanoid" id="W4JZB4"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="632"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="640"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="683"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW78918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="694" mass="77228" checksum="DC1ED1FDE4ECF981" modified="2014-03-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZI4</accession>
    <name>W4JZI4_HETIT</name>
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        <submittedName>
            <fullName evidence="9">Glycoside hydrolase family 31 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_410606</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
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        <property type="protein sequence ID" value="ETW78495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="interactions" value="51"/>
    </dbReference>
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    <dbReference type="GeneID" id="20672883"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_410606"/>
    <dbReference type="eggNOG" id="KOG1065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000631_11_0_1"/>
    <dbReference type="InParanoid" id="W4JZI4"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030459">
        <property type="entry name" value="Glyco_hydro_31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF133">
        <property type="entry name" value="P-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00707">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="7">
        <location>
            <begin position="249"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="8">
        <location>
            <begin position="680"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW78495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="898" mass="97678" checksum="F22F94A788BE0574" modified="2014-03-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZK5</accession>
    <name>W4JZK5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 45 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gh45.1</name>
        <name evidence="2" type="ORF">HETIRDRAFT_104329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549290.1">
        <property type="nucleotide sequence ID" value="XM_009550995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZK5"/>
    <dbReference type="GeneID" id="20665988"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_104329"/>
    <dbReference type="eggNOG" id="ENOG502S75I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1267040_0_0_1"/>
    <dbReference type="InParanoid" id="W4JZK5"/>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22278">
        <property type="entry name" value="DPBB_GH45_endoglucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22514">
        <property type="entry name" value="EXPB1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004843988" evidence="1">
        <location>
            <begin position="21"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="218" mass="22561" checksum="171768DA5442FB22" modified="2014-03-19" version="1">MKLLLSVSLATVYGAIFVHGTLDTRATGGYVQNSSGSASFTMYSGCGSPACGKTASGFTAAINQLAFGSGPGLGPGDACGRCFSLTGQADPYSPAFTGPFKTVIVKVTDLCPVSGNEEWCGQSTSATTNQHGAPFHFDLCEDTGAAAAFFPSGHANGQELTAQVCGMELASTGSLQVFGPQALAAATKVHLIDFYSFELSDSLRDIDRHRSFVKYPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZP0</accession>
    <name>W4JZP0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_323526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549294.1">
        <property type="nucleotide sequence ID" value="XM_009550999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZP0"/>
    <dbReference type="STRING" id="747525.W4JZP0"/>
    <dbReference type="GeneID" id="20670970"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_323526"/>
    <dbReference type="eggNOG" id="ENOG502S808">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056788_1_0_1"/>
    <dbReference type="InParanoid" id="W4JZP0"/>
    <dbReference type="OrthoDB" id="3022198at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047655">
        <property type="entry name" value="Transpos_IS630-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033545">
        <property type="entry name" value="transpos_IS630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="146"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="319" mass="36758" checksum="7578881020507ACC" modified="2014-03-19" version="1">MPPPLPHPVRELIIDWHYNDQLTVSEIAHRARCSKSSVYRILQLEREFGLIINPNARTRGARQILDQSDKDSIKAFIERNPAAYLDEIQQHLLDTKNVWVSTSTISRTLAQMEITIKQISKTAAERDELVRAIWKGKHGRIAKENIVWLDESSVDDLTNQRLRGWAELGRACVRRDTFIRGQRYSILPALTIEGIIALDIFEGSVTKERFIKYLRTHLAPLLNPFGPRSVVIMDNCSIHHDEEIRQVIEVECGAQLIYLPPYSPDMNPIEHAFSAMKAWLRRHEDEAVRPEARRWLIQRAIASVTEEDALGWIDHCGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4K055</accession>
    <name>W4K055_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_323190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549034.1">
        <property type="nucleotide sequence ID" value="XM_009550739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K055"/>
    <dbReference type="GeneID" id="20670945"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_323190"/>
    <dbReference type="HOGENOM" id="CLU_052689_1_0_1"/>
    <dbReference type="InParanoid" id="W4K055"/>
    <dbReference type="OrthoDB" id="3232644at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="53090" checksum="D8AF20356774FBDD" modified="2014-03-19" version="1">MSTEPSSMRLPAELWLRIFQLATVVPGILEIEALDPFDSPTALLPHSEYEWLSSTAKSALVTKRALVQVCKDFYWLATPLLYEAVFIGPPKSTSVRSLRDAIQKSKQVAETNTSGGRALGSWTRRLVMTRTNYYDPSFDEVGFQCLADIMSCMPNLEILSVHTNALDLYIPSFVVDSLIATSKCSLRKLYFQRDSGLHLRASDCINLLESCRELRAVSLGDFGGCKGLCPIDLLRVSEPSFLSICSTPAGCASKHLEHTPARPSLRHALFSRHGHNTENSVAAMCHFLTIQGQYLESIQLDARFTPYDWTQIALNLFADYCISLTHLTLILGSTSWRSLNPNGLTLPPITHLGLYFDRHQVSNPGDFHQLFRCLSNTHAPSLKVVRILEPRRARHLRRYVSEGRDVGFSFLSSCKFRLEDFDGQSIFPMPTARQSRLPRRAYLTFSKQRGLLSNVFHSPPSDNDLTMLLAGSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0F7</accession>
    <name>W4K0F7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_445736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549100.1">
        <property type="nucleotide sequence ID" value="XM_009550805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0F7"/>
    <dbReference type="GeneID" id="20675643"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_445736"/>
    <dbReference type="HOGENOM" id="CLU_729695_0_0_1"/>
    <dbReference type="InParanoid" id="W4K0F7"/>
    <dbReference type="OrthoDB" id="3181669at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="41468" checksum="74DB81844B959219" modified="2014-03-19" version="1">MTNVLNKFPAHLPILESLTLNCIRTVSFPDAELPRGTNSILHSHTPSLRRLNLVGITLPWTAPLFRGLTHLDVQLEAWHPKLDTFLNVLDACPDLELLRLYEAHPVSSDEAIPRRVNLPRLQTIDLQGPSAAYILAFLVPPATAHIHIPFFRYQPAWHSHLPNLPAIDTFVLSLYNPPGSSPSEPVLRGTAAPARTGASTAAPRVLLESPFGDRPLLIVFWIDVACLVGLCRASTFLLGPGDVADPKFACTEWAQGLANMASVRTLALHTRKAFCALVGMTDDTETDTDADADAAPVLCPALEHLELGDFQLSRADAARVERWVARRHAQGASALQTMRLCDMRPLLLVVVQRLRKVVPTVVVFDEGVPVGTTFGRTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0M8</accession>
    <name>W4K0M8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_324788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549171.1">
        <property type="nucleotide sequence ID" value="XM_009550876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0M8"/>
    <dbReference type="GeneID" id="20671082"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_324788"/>
    <dbReference type="HOGENOM" id="CLU_1943117_0_0_1"/>
    <dbReference type="InParanoid" id="W4K0M8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="130" mass="14511" checksum="262074290D5EF4BE" modified="2014-03-19" version="1" fragment="single">LGAHSTSTLISGSIFYLEALFTIKTYIQLWNKPAFAPHSSELIRTRLNHRNHLCRLPKTCHPRRSASFAFVLVSSLVPPSSLVYCQSPVWLLKHVVVGRDTTFSLPTASPTRPTECLVGVRRSPETVRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0N5</accession>
    <name>W4K0N5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_324079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549007.1">
        <property type="nucleotide sequence ID" value="XM_009550712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0N5"/>
    <dbReference type="GeneID" id="20671018"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_324079"/>
    <dbReference type="HOGENOM" id="CLU_2223607_0_0_1"/>
    <dbReference type="InParanoid" id="W4K0N5"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="106" mass="12268" checksum="6FA5CBB39038D5EB" modified="2014-03-19" version="1">MFISPSVRRVYLEPSETEDLQNQVAQLEARIESLRRDKNMLIDKCESTIAKAAKHAEGEKAARLEAQTAQKEAHDMRKKYEVIKAKYQDIKNQSVFYPHVLSPLYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0P9</accession>
    <name>W4K0P9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_386891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549022.1">
        <property type="nucleotide sequence ID" value="XM_009550727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0P9"/>
    <dbReference type="STRING" id="747525.W4K0P9"/>
    <dbReference type="GeneID" id="20672296"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_386891"/>
    <dbReference type="HOGENOM" id="CLU_1094430_0_0_1"/>
    <dbReference type="InParanoid" id="W4K0P9"/>
    <dbReference type="OrthoDB" id="3596986at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="301" mass="31984" checksum="DF962BD658DA129B" modified="2014-03-19" version="1">MPRARAPRPEGRPRPAKRRKLGEPASRSDVDADADVAAGFAEDEAEADGEAETESRARDLVLETSCERFLVAACVPGGAEKEKEKENAGAGKSARRRWTISLIADGPAEPAAAAPPRPPPRPPSPPSTIRTLTTGESENVNEKENEKAMAVDLETSPLPEPSTNSAPGATPLSDPSVAQPSEHVAAGTDGARSPSRPPPDASSSAETAPASLTLTKNTLERQPRSQSPSLSSSMPPPPPPPIQPAPASEPKQNTQVLHVLQRDLDESNIEFDKAEVRILGDVGADGMRRGWAIEVRRWRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1S0</accession>
    <name>W4K1S0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_147175</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548237.1">
        <property type="nucleotide sequence ID" value="XM_009549942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1S0"/>
    <dbReference type="STRING" id="747525.W4K1S0"/>
    <dbReference type="GeneID" id="20667187"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_147175"/>
    <dbReference type="eggNOG" id="KOG2099">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010198_1_0_1"/>
    <dbReference type="InParanoid" id="W4K1S0"/>
    <dbReference type="OrthoDB" id="9215500at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04300">
        <property type="entry name" value="GT35_Glycogen_Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000002">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000003">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF3">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE, LIVER FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW79674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="871" mass="98585" checksum="1F278868AE086583" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1X9</accession>
    <name>W4K1X9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BAG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_171676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548345.1">
        <property type="nucleotide sequence ID" value="XM_009550050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1X9"/>
    <dbReference type="GeneID" id="20668357"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_171676"/>
    <dbReference type="eggNOG" id="ENOG502SY3Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_392340_0_0_1"/>
    <dbReference type="InParanoid" id="W4K1X9"/>
    <dbReference type="OrthoDB" id="333905at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAG" evidence="2">
        <location>
            <begin position="403"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
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        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
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        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <end position="651"/>
        </location>
    </feature>
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            <end position="691"/>
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            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW79797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="703" mass="74348" checksum="29E7839D5140A6A8" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4K283</accession>
    <name>W4K283_HETIT</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">HETIRDRAFT_103518</name>
    </gene>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_103518"/>
    <dbReference type="HOGENOM" id="CLU_032924_0_0_1"/>
    <dbReference type="InParanoid" id="W4K283"/>
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    </dbReference>
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            <end position="225"/>
        </location>
    </feature>
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        <location>
            <begin position="338"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="509"/>
        </location>
    </feature>
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            <begin position="110"/>
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        </location>
    </feature>
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        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW79912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="509" mass="54452" checksum="39BD430F7DEB7B31" modified="2014-03-19" version="1">MSSLLSVLKTKLGEYMLSLPDGTAEYEDYEAWAQGFAKRVAVFDRSARGQDVPELAAWVAEAESGLDHVATNDWLAWGSRILPQRAARFAAQKQQQAAEEQALAEEAAWVAVTEREAEEAEAMRAAAARQLAKADRRRRREALVEAMFNGSLDPEQGDRQLSELEAESVLPLPLFLHSPSPSAAASSSRPVPSADSSHPDPSADSSYPDPSADSSYPDPSADSALASATDALDRMSMGLAAAAAPTDAKGKKTAAAVVVKFAHQRTPPLGRVVLPLGPGTGRMSTVRSPMERNGAGKVLEDPPELLPGDVLADYACHRCATAFQTKVFRDLKGCSFQPGWMPMEKGKGKSKEKGKGKSKEQSAPKAEERERPLKRRKVEVVVPVRSVGDSIAQTKAARTRKPVQRLPTTARAVLAPTRSRSVAVPALSDSSRLSPIVAQGIASDLRYRIAVAEGTRASLARSIKMWQAELESLEVQAGPSTSSDVVLVEDSSAAEDSDMSVSGDFVPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
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    <name>W4K322_HETIT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">HETIRDRAFT_451873</name>
    </gene>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009548702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K322"/>
    <dbReference type="GeneID" id="20676209"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_451873"/>
    <dbReference type="HOGENOM" id="CLU_776249_0_0_1"/>
    <dbReference type="InParanoid" id="W4K322"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="357" mass="38695" checksum="498F69CCD1ACCC46" modified="2014-03-19" version="1">MGIDDENVVMDAASLSRTNVMKRRSAVDAASGHPFSPRNPATQRPRAHPLDGSHPPLPRAASPPKPSARSPLCTLAPRILVLVLSAVDVPAVEVTIFNGVDANPFDITAPASAREHDVLVEFPTLVNRTLKTLWARDVADPPDENMYQCRRFLYSSLKHRFHVSTVTPQSRGVFLSNTASTDTLLAADTASTSTLSVSRYSPSSGPSSHIPKSWSARPRESRCGHMGSAYVGWRFLLKIGRAVSIRRVIKQELGQYTPAPASASNEFSPTLYSVEEAKPAAPVQRASSSSASNRRVDHPEDHYPLQPNLLRQQPPYSAESLLRHLPLSGRSSGDSRFRKASSECSSSAGCSLPPIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3T9</accession>
    <name>W4K3T9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_322642</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548289.1">
        <property type="nucleotide sequence ID" value="XM_009549994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3T9"/>
    <dbReference type="FunCoup" id="W4K3T9">
        <property type="interactions" value="486"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K3T9"/>
    <dbReference type="GeneID" id="20670891"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_322642"/>
    <dbReference type="eggNOG" id="KOG2256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011272_0_0_1"/>
    <dbReference type="InParanoid" id="W4K3T9"/>
    <dbReference type="OrthoDB" id="10266662at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030691">
        <property type="term" value="C:Noc2p-Noc3p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687">
        <property type="entry name" value="NUCLEOLAR COMPLEX 2 AND RAD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687:SF4">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03715">
        <property type="entry name" value="Noc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW79731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="689" mass="77735" checksum="3220611256B41369" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4R4</accession>
    <name>W4K4R4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_427702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547492.1">
        <property type="nucleotide sequence ID" value="XM_009549197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4R4"/>
    <dbReference type="GeneID" id="20674225"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_427702"/>
    <dbReference type="HOGENOM" id="CLU_1053941_0_0_1"/>
    <dbReference type="InParanoid" id="W4K4R4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW80787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="29358" checksum="387F755D3B862C4E" modified="2014-03-19" version="1">MSRKGRNTLADSWTSTPTFKEFCEKVYKLYPGSEEEHKWSVLDMDKLVGKMSRVSILSLSELDDPYNLQDIHDAAQFVLHGTTSAYSTMSTDISRAAPAAPPTNAIKAEDLATMFEWLTDTFIKAIATQRTSRPADRPSRQPGQGGNNCMFCGSPEHFMHACPEVTEYIQIVKCKRNIEGKVESRTVGDWTDDVYGKRGANSPDDDSLPSQFTLIAGCHPDLPTHRRPVNHKPQTQTIHTPNMGREGMQNGTDRTFGAYPITGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4U5</accession>
    <name>W4K4U5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial intermembrane space import and assembly protein 40</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Mitochondrial import inner membrane translocase TIM40</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_28180</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546887.1">
        <property type="nucleotide sequence ID" value="XM_009548592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4U5"/>
    <dbReference type="STRING" id="747525.W4K4U5"/>
    <dbReference type="GeneID" id="20669277"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_28180"/>
    <dbReference type="eggNOG" id="KOG4149">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127296_2_0_1"/>
    <dbReference type="InParanoid" id="W4K4U5"/>
    <dbReference type="OrthoDB" id="7481291at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039289">
        <property type="entry name" value="CHCHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622:SF0">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CHCH" evidence="12">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW80380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="61" mass="6868" checksum="7EDB2E00DB9BD74E" modified="2014-03-19" version="1" fragment="single">GKINWDCPCLGGMAYGPCGMQFREAFSCFVFSEEEPKGIDCVEKFKAMQDCFRANPEVYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4W9</accession>
    <name>W4K4W9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="9">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_434768</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="9"/>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547551.1">
        <property type="nucleotide sequence ID" value="XM_009549256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4W9"/>
    <dbReference type="STRING" id="747525.W4K4W9"/>
    <dbReference type="GeneID" id="20674772"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_434768"/>
    <dbReference type="eggNOG" id="KOG2448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014271_4_1_1"/>
    <dbReference type="InParanoid" id="W4K4W9"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009082">
        <property type="term" value="P:branched-chain amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002068">
        <property type="entry name" value="PRK00911.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF5">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="12">
        <location>
            <begin position="3"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="13">
        <location>
            <begin position="340"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW80852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="535" mass="57347" checksum="C59C89E8F87D5598" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4K511</accession>
    <name>W4K511_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_440488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547525.1">
        <property type="nucleotide sequence ID" value="XM_009549230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K511"/>
    <dbReference type="GeneID" id="20675267"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_440488"/>
    <dbReference type="eggNOG" id="KOG4476">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1378286_0_0_1"/>
    <dbReference type="InParanoid" id="W4K511"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF1">
        <property type="entry name" value="CAMP INDEPENDENT REGULATORY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW80824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="198" mass="21820" checksum="95319F7B6965D190" modified="2014-03-19" version="1">MSSGPRLTISLPSWPPGPITMPMTYTTGPSLTGAFFRSLEDASKVFYAAARGVLPLCSDRLNEAERKQVRPGNVYVYDSTALVRWADGRRWGASRVRGFFLCYPEKSSRNRYDLKNPLARVACTANVTLPNGQIRQWGMVLYLDNSSPLTPVGDIPNVGDTHVPPGRVVITQGSQQGSELHAYFVPAVNVRRLQANSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5Y4</accession>
    <name>W4K5Y4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Threonine protease T2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_169216</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547208.1">
        <property type="nucleotide sequence ID" value="XM_009548913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5Y4"/>
    <dbReference type="STRING" id="747525.W4K5Y4"/>
    <dbReference type="GeneID" id="20668210"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_169216"/>
    <dbReference type="eggNOG" id="KOG1592">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021603_1_0_1"/>
    <dbReference type="InParanoid" id="W4K5Y4"/>
    <dbReference type="OrthoDB" id="2262349at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04701">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF43">
        <property type="entry name" value="ASPARAGINASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="240"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="283"/>
            <end position="286"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="3">
        <location>
            <begin position="211"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW80461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="369" mass="39802" checksum="7667B3153A7B801E" modified="2014-03-19" version="1">MQEKKPLIPKPSNKPRYVLVIHGGAGTMSREASTPEREARYKTALSSALRAGHAVLQDGGEAMDAAVAAVMSMEDCPLFNSGKGAVFNVVGQNELEASIMLSRPPSSHPKIPHKRRGFSLTLLTRTRNPSHMVRELYLSPQSSPHPFLSGAAAETVGETLGEQLVDPSYFFTEARWREHRRGLGLPETPFPPGHVLSSPPSELNLDQLPTGTVGAVALDVHGCIVAVTSTGGRTNKMAGRIGDTPHMGAGFWAEEWKTEGWIRRTWNKALGRKSKQAVGVSGTGDGDYFIRQNTACTLARRMQYLHEPLSKAAQYAVDDLRRVGGDGGLIAVDSEGHVAMPLNCPGMYRGLIGVDGIPKTAIFSDEELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4K634</accession>
    <name>W4K634_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_319127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547261.1">
        <property type="nucleotide sequence ID" value="XM_009548966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K634"/>
    <dbReference type="GeneID" id="20670574"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_319127"/>
    <dbReference type="HOGENOM" id="CLU_2564622_0_0_1"/>
    <dbReference type="InParanoid" id="W4K634"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="82" mass="8780" checksum="1B4CD4A5DBDA9851" modified="2014-03-19" version="1" fragment="single">FGRCSAQSRNRSGAIISHSPIASHSSTPALEVVLVLCSALRATSSVTFWSPPRGVSIQNYLKESTSLVPTNSGARRTTNSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4K635</accession>
    <name>W4K635_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_169525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547494.1">
        <property type="nucleotide sequence ID" value="XM_009549199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K635"/>
    <dbReference type="GeneID" id="20668224"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_169525"/>
    <dbReference type="HOGENOM" id="CLU_513929_0_0_1"/>
    <dbReference type="InParanoid" id="W4K635"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="530" mass="58141" checksum="085EC9A4416EE16F" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4K650</accession>
    <name>W4K650_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_101903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547511.1">
        <property type="nucleotide sequence ID" value="XM_009549216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K650"/>
    <dbReference type="GeneID" id="20665809"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_101903"/>
    <dbReference type="HOGENOM" id="CLU_1699692_0_0_1"/>
    <dbReference type="InParanoid" id="W4K650"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="155" mass="16324" checksum="FC554EA6A5B38C44" modified="2014-03-19" version="1" fragment="single">CAHTAEAARPGPLERLTGVFSAQPPSAPPRPPSCRRPSPSSAEWRPSWLPSVLTSSCIPTGRVHRGPACPGGGGRGTLRPPASLPLLSRPHCTAYPRPATQPPSPHSIKPRRLSTSLPSISSRKCNLASSLALVACGNSNLLRWTSRPARLHGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6Q6</accession>
    <name>W4K6Q6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_318448</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 14 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546072.1">
        <property type="nucleotide sequence ID" value="XM_009547777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6Q6"/>
    <dbReference type="STRING" id="747525.W4K6Q6"/>
    <dbReference type="GeneID" id="20670513"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_318448"/>
    <dbReference type="eggNOG" id="KOG1315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037348_0_0_1"/>
    <dbReference type="InParanoid" id="W4K6Q6"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="126"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW81424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="358" mass="40454" checksum="D2B39BE08AAC6C0A" modified="2014-03-19" version="1">MSELQQPAFSPVLGSSEDEEDETIKKRWYHFLPLCCAVLLLLAPHPSLLYVLVNYHLLTLHSPLLFSLHLCVTYALTFLAFCSLIVCVARDPGPVPSIEQENEQDSGMSLTDALMAPPDYDYTAPGKWCRVCWAPKHERTHHCSQCGRCVLKMDHHCPWIGGKCIGHRTYPSFLHFLFSITLLSVYIAAISIQGLSFAFRNPLAIDPVTPVNELFLAFAGVVFTMVIGSFFCYHIYLVLTNQTTIENISPFILLRHLPPLPPSDDTNRKLSNPPIEHELSYAQRRLVKDTRGVIRLYDLGWRNNLEQTFGPARASWRCWAARMLWGGQCGGDGIKFPVNPRAEDMLARLAVELVRSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6U2</accession>
    <name>W4K6U2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_383923</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546189.1">
        <property type="nucleotide sequence ID" value="XM_009547894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6U2"/>
    <dbReference type="STRING" id="747525.W4K6U2"/>
    <dbReference type="GeneID" id="20672175"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_383923"/>
    <dbReference type="eggNOG" id="ENOG502S2FP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036920_0_0_1"/>
    <dbReference type="InParanoid" id="W4K6U2"/>
    <dbReference type="OrthoDB" id="2278929at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW81557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="437" mass="45884" checksum="618E6EA2B29A38B2" modified="2014-03-19" version="1">MSPSPSDNLPWPQPTPPPNPSKRTRHWSGAAPLDHRRSIVPRQVVVNQTGVAEAAEQCQFTSGNDVVSCFPTANSIFPQHEWATFVWNSNLPDFTQTDRVDIRLFHGDSGHQVLEMLDQLNPRGRAGAVTAQVNDTWFPDGGLGWSGTNISYPFYWVITRANVSPNDTTTPQATFTAVQTTYADSVTSSLASVSSVAAASATSVAAISSASVASTRSVASVSASQAATASTPGVSTTSSGAGGLQQDSGSSFPHWAIAVIVVLGFLAIVATCVLIFLIARRVRRNRSLANSRRGSIGSASPMITNTLGGAPQSPVLDQPGMQGFGDPPSIAQRPPSISSPDGASTISHPHSAGEGLFSGADAAIMADAFRKALRKPDFAEPAIEEGDSPEAVERRDAELLSRELAEEGRDIRSVSSSRGVRVETLSDGGGTIHDSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4K708</accession>
    <name>W4K708_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_104913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546224.1">
        <property type="nucleotide sequence ID" value="XM_009547929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K708"/>
    <dbReference type="GeneID" id="20666035"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_104913"/>
    <dbReference type="HOGENOM" id="CLU_1107255_0_0_1"/>
    <dbReference type="InParanoid" id="W4K708"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="251" mass="26820" checksum="036C7FA3146A0E10" modified="2014-03-19" version="1">MAPVRLPAFILKTRGPLPCTGAFEFSPHYFPGSTPSHSAANPLPASAIFLSLLCVSCAQEAAGLRLAYVLASAPSCDPAPAIRASSLPPRRDGDLRAALGTDSRPQQTAFNKLTSPYLMMRSPAFVSRPLRSSRPALAFPGPPLPGRCASEPAMHEAARSTWPMLVLGESLAAHTRLRSQDNRECIFDNHNNAPSELTLLGGSERLPAHRFCVVSACIPSASPVGTAVPEHRLHFPGWPSFLAIVLWARAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4K782</accession>
    <name>W4K782_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Chromatin modification-related protein EAF6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_384074</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546312.1">
        <property type="nucleotide sequence ID" value="XM_009548017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K782"/>
    <dbReference type="STRING" id="747525.W4K782"/>
    <dbReference type="GeneID" id="20672183"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_384074"/>
    <dbReference type="eggNOG" id="KOG3856">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112128_0_0_1"/>
    <dbReference type="InParanoid" id="W4K782"/>
    <dbReference type="OrthoDB" id="440324at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13476">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="139"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW81692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="189" mass="20970" checksum="9CC7DFAB037D3252" modified="2014-03-19" version="1">MPNDGPGPSPEDKARYDGARKELIQALSKKRAVDKQLAQLEIQIYNLESSYLLETSAHSGGNIIHGFDGYLKNQMTKKKYELNDGDRIFSTSSLTFQKSIELSGEGEESSATVDDYKQPTPGLTTVVLPPASRAQELTAAQLKKNRDREYQRKKRAAAGRISMGTVSDEESAPSTGRRPTKRSRMMDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="1 2">
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009548141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7S5"/>
    <dbReference type="GeneID" id="20670396"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_317175"/>
    <dbReference type="eggNOG" id="ENOG502S1UM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067896_0_0_1"/>
    <dbReference type="InParanoid" id="W4K7S5"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="285" mass="32130" checksum="641DE12F6F84F7B8" modified="2014-03-19" version="1">MSRGNRVVSSGNMSTSMRDNYNQHGVGEYYRKVGVTYRNPHYPGVRRCLFAWFTSWWQQEHANIDARGPTIFDMACGVHSSKVIIALQEWWLSGLSTNNQPTPTEITQMSIPLPRSKSHILLPPLDSHTPRPLVMAADPYTSEAFKARTSLPCAALSFSDIAQGIMPASTSRLPLSAPAQAATAKSKDAVSPREIIPNLVEMVICSFALHLIETPSELFALLWELSTKCRWLVILAPHKKPQIKDGWGWSKWDTEKWSNCSMAEVQGEFLFDRVHCRVYRSLNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2024-07-24" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4K812</accession>
    <name>W4K812_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_451574</name>
        <name evidence="3" type="ORF">HETIRDRAFT_451603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546480.1">
        <property type="nucleotide sequence ID" value="XM_009548185.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009548223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K812"/>
    <dbReference type="GeneID" id="20676166"/>
    <dbReference type="GeneID" id="20676172"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_451574"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_451603"/>
    <dbReference type="HOGENOM" id="CLU_1787101_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW81928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="145" mass="16069" checksum="EC65EAB18068106D" modified="2014-03-19" version="1">MRRTEPIYVDLTLHCISSTAARFLLYRPKPKGTNPVKTRIIYYPAAPAFPRARSRPPPLALSPLAVPDLINIAQPADLDARIASQATGDETPGNAARHQLPGRPRAGPHPHLPSPSFFRRVFDARAFLFVFADVYFAGLAFSREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4K892</accession>
    <name>W4K892_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_418021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546596.1">
        <property type="nucleotide sequence ID" value="XM_009548301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K892"/>
    <dbReference type="GeneID" id="20673439"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_418021"/>
    <dbReference type="HOGENOM" id="CLU_2210393_0_0_1"/>
    <dbReference type="InParanoid" id="W4K892"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="107" mass="12448" checksum="AC76E272554147D4" modified="2014-03-19" version="1">MRGIVFVYRGSSRPPRPKVPKCIRDVVVPEIDWATLFRTAMMILPDGTEMARSEWHRRKNSPLFSPTHFASIHYALINHRKARFNSGARTLACLLTYKKLKHARICR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8W3</accession>
    <name>W4K8W3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lactate 2-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">lmo1</name>
        <name evidence="7" type="ORF">HETIRDRAFT_440215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546770.1">
        <property type="nucleotide sequence ID" value="XM_009548475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8W3"/>
    <dbReference type="FunCoup" id="W4K8W3">
        <property type="interactions" value="91"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K8W3"/>
    <dbReference type="GeneID" id="20675238"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_440215"/>
    <dbReference type="eggNOG" id="KOG0538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020639_0_1_1"/>
    <dbReference type="InParanoid" id="W4K8W3"/>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF143">
        <property type="entry name" value="FMN-DEPENDENT ALPHA-HYDROXY ACID DEHYDROGENASE PB1A11.03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="32"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="111"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="360"/>
            <end position="364"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW82228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="435" mass="47411" checksum="26D3EAD7DBBB1DF9" modified="2014-03-19" version="1">MSLRAALENGETPPETWSSFMADIYRNKNPPVNTTYDFDKLEEKAREVTKDYHAAFLYTFGSAGSGSTNRANRQALKQWRIVPRMLRDASDRTLETTLFGVKYKSPILVAPIGVQGIMHRDGELATARAAAKVGVPFIMSSASSRSIEDVAEANGAGPRWFQLYWPRTDAITLSLLARAKAAGFTALVVTLDTMLLGWRPHDLDAAYLPFAHGVGIQIGTSDPAFMAAQQLPVRPRERPAWPFDAAALDARLRAGDAEARANARLGARWLAQLNSGLFRTWEDVAFLRAHWEGPIVLKGIQAVADAHRAMDVGVDGIVVSNHGGRQIDGAVPSFVALEQIMLSRRVTDAQRAGTFTVLFDSGIRSGSDVIKALAMGAQAVLVARPYMYGLAVGGERGVEEVLRALHADTEITLGLSGYKNVGEVWHKKEEVMVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4KA37</accession>
    <name>W4KA37_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_316548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544987.1">
        <property type="nucleotide sequence ID" value="XM_009546692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KA37"/>
    <dbReference type="STRING" id="747525.W4KA37"/>
    <dbReference type="GeneID" id="20670342"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_316548"/>
    <dbReference type="eggNOG" id="ENOG502SHSB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1154038_0_0_1"/>
    <dbReference type="InParanoid" id="W4KA37"/>
    <dbReference type="OrthoDB" id="2576233at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="241" mass="27507" checksum="A64534B40BD94EFC" modified="2014-03-19" version="1" fragment="single">IISPDKTQLTLFHNKSAYPIYMTFGNLLKDICKKPSQHSQILIEYLPTTQLDHFTNNAACHRAMSNLFHSCVHKILEPLRCHGKEGLAMVSGDGIWWCCHPILAILMGDYPEQCLATCTLFGDCSKYTVPHNKLRDHIHYMAHNLNDVQDLLDLADEDPASYNSACHNACNKPVYHPFWEAFPYGNIFIAITSDILHQGYQGIVKHLVIWLNDASGVVVRNGFSPRHDRGFLFFRMYLVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KA47</accession>
    <name>W4KA47_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_408843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544994.1">
        <property type="nucleotide sequence ID" value="XM_009546699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KA47"/>
    <dbReference type="GeneID" id="20672732"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_408843"/>
    <dbReference type="HOGENOM" id="CLU_3068946_0_0_1"/>
    <dbReference type="InParanoid" id="W4KA47"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="53" mass="6164" checksum="AB20A77A0299BB6E" modified="2014-03-19" version="1">MKKSSQAHISRRPCRASTRASDPNKKHPAKRVGVREQKERSEECGMRSKRRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAJ2</accession>
    <name>W4KAJ2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_165205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544740.1">
        <property type="nucleotide sequence ID" value="XM_009546445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAJ2"/>
    <dbReference type="STRING" id="747525.W4KAJ2"/>
    <dbReference type="GeneID" id="20667967"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_165205"/>
    <dbReference type="eggNOG" id="ENOG502SRIE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003921_3_0_1"/>
    <dbReference type="InParanoid" id="W4KAJ2"/>
    <dbReference type="OrthoDB" id="3189091at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="332" mass="37940" checksum="1696E95088D22A97" modified="2014-03-19" version="1">MTTPSMPARGDRTAPTFDPRQPRELRRYFSDLEFHFNRSTVVDTTERKKHACRFLDVDTCELWETLAEYTNAAMSYEDFCKAVYRLYPGSEEERKWSVADMDKLVGESSRIGILSLSDLGEYYRQFLVITSFLLSKDHISTAKQGRAFTRGFQPELWGRISQRLQLKFPDHFPDDPYQLQDIHDAARFILHGTSSTFQLASADSSRATRRTKTEPSIKTEDLATMFERIAETFIKALANQPAQVSTMSQPPRARRDPSSSDRCMFCGGPDHLYVNAVRLLNISGLGSARRTRKEGSYYRQAHSYREKFRVTTSRIASMNGTVATPARSPPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAX8</accession>
    <name>W4KAX8_HETIT</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_450663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545243.1">
        <property type="nucleotide sequence ID" value="XM_009546948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAX8"/>
    <dbReference type="GeneID" id="20676068"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_450663"/>
    <dbReference type="HOGENOM" id="CLU_2558553_0_0_1"/>
    <dbReference type="InParanoid" id="W4KAX8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="82" mass="9535" checksum="BCDA531491FD9400" modified="2014-03-19" version="1">MHSTPDLPPDPVDAPVEIPRSGTQRERRPRRTRRSMAIVRRAPWRDDDDRERERIQHSLHCSLFKGTPRDDKALTKPKPASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBF2</accession>
    <name>W4KBF2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aspartic peptidase DDI1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_450471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545021.1">
        <property type="nucleotide sequence ID" value="XM_009546726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBF2"/>
    <dbReference type="STRING" id="747525.W4KBF2"/>
    <dbReference type="GeneID" id="20676050"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_450471"/>
    <dbReference type="HOGENOM" id="CLU_003921_0_0_1"/>
    <dbReference type="InParanoid" id="W4KBF2"/>
    <dbReference type="OrthoDB" id="2801388at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27384" checksum="8C6EF33BD21B8E80" modified="2014-03-19" version="1">MATQVTLTQCKLLSLSAKVCSQVREATSARRSPTKDASNVRTFYQDADLPYAIDDLKSPTRPTISSFVNVLHQPETPPPGAIIIPDMYETYLKSLQPGQVPQPLIVAKESSALRSIVPLVDHQQEVKCVIDPGSQVIAMSEGICNELALIYDPEIILNMQSVNGKIDQSLGLARNVPFLIGDITLYLQIHIIQNPAYDVLLSRPFDILTKSIIKNYSNEDQTITISDLNAGLQATIPTIRREPPRVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBJ1</accession>
    <name>W4KBJ1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_163506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_163506"/>
    <dbReference type="eggNOG" id="ENOG502T1AE">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2386433_0_0_1"/>
    <dbReference type="InParanoid" id="W4KBJ1"/>
    <dbReference type="OrthoDB" id="3197992at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW83099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="94" mass="11203" checksum="033CA42E997A0683" modified="2014-03-19" version="1">MLRKSIQRMRSRCRFHRFSIVAHPLLQHYVRLYSTGNTTDCNSPHCAFSAAHMHKTARTCMCHRVMYDDRRVLNLFQEPCDDCKEAGFDRGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
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    <name>W4KBM6_HETIT</name>
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        <submittedName>
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        </submittedName>
    </protein>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
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                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Solheim H."/>
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                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="747525.W4KBM6"/>
    <dbReference type="GeneID" id="20669077"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF9">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="573"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="607"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="125"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW83193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="654" mass="73659" checksum="60F4D232845EB9FF" modified="2014-03-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBS2</accession>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
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                <person name="Gonthier P."/>
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                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
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                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
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                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
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                <person name="de Vries R.P."/>
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                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
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    <dbReference type="HOGENOM" id="CLU_1133702_0_0_1"/>
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    <dbReference type="InterPro" id="IPR045339">
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    <dbReference type="PANTHER" id="PTHR40465">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="30"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW83297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="245" mass="26655" checksum="CA1FFA332384C555" modified="2014-03-19" version="1">MSHPSSDSRRLGPASANVAWVAYLNTSAIVLSDAVIAGGLCYRLASKAGLSDFAKTKDLVSKLISYVVGTSMLTSICAALTLITFAARPHTFIFIAFFLLLSKLYFNAMLANLNSRTKLRESTTGHDDVMLSIPLSITERGRTNDALHALSHSQTGSMAKNTPMQVHMAVDRVQVYDPKVSNPCPGHLADLSRVSSRALTPRHHPRPAARAVYQTAYEARDANIRSARAAAPDRDRTRTVMPQMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBW8</accession>
    <name>W4KBW8_HETIT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_316266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545619.1">
        <property type="nucleotide sequence ID" value="XM_009547324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBW8"/>
    <dbReference type="GeneID" id="20670309"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_316266"/>
    <dbReference type="HOGENOM" id="CLU_003921_8_1_1"/>
    <dbReference type="InParanoid" id="W4KBW8"/>
    <dbReference type="OrthoDB" id="5596707at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW83357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="116" mass="12993" checksum="38F032845888D228" modified="2014-03-19" version="1" fragment="single">CNELVLIYDPKIVLNMQSANGEINQSLGLARNVLFLIGNITLYLQVHIIQNPAYNVLLGWPFDILTKSIVKNYSNEDQTITISDPNTGQRATIPTIRQGPPRVLHQRQAGFCDSMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCM1</accession>
    <name>W4KCM1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_433775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545374.1">
        <property type="nucleotide sequence ID" value="XM_009547079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCM1"/>
    <dbReference type="STRING" id="747525.W4KCM1"/>
    <dbReference type="GeneID" id="20674700"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_433775"/>
    <dbReference type="eggNOG" id="ENOG502SM2S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007930_0_0_1"/>
    <dbReference type="InParanoid" id="W4KCM1"/>
    <dbReference type="OrthoDB" id="3261862at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="808"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="864"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="649"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="808"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="881"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="940" mass="101397" checksum="98398E59AA533C39" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCP6</accession>
    <name>W4KCP6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_165796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545759.1">
        <property type="nucleotide sequence ID" value="XM_009547464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCP6"/>
    <dbReference type="GeneID" id="20668012"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_165796"/>
    <dbReference type="HOGENOM" id="CLU_035509_11_4_1"/>
    <dbReference type="InParanoid" id="W4KCP6"/>
    <dbReference type="OrthoDB" id="3350812at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="16"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW83514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="211" mass="23811" checksum="D699BAB1ECE56C75" modified="2014-03-19" version="1">MSDPASSVFNLRVVGYVEVVSATLLGYEWAILLDQEVSLIWNSPWNLSKILYLLSRYTPVLDMSLSMQHVPCNLRCRNSLYRHRNSNIGTKILSSLGSLWIIWVCVNIWVLVKFMDSLVFADPPSALIPGCYLANGDPIVFVSFASLLFVETVIVILTVYKGFQLTHQSKSPLLLTLYRDGIVFYLCLLRMSFTEYDSIIPAAILMMTSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W4KES7</accession>
    <name>W4KES7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_62256</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543249.1">
        <property type="nucleotide sequence ID" value="XM_009544954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KES7"/>
    <dbReference type="FunCoup" id="W4KES7">
        <property type="interactions" value="528"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KES7"/>
    <dbReference type="GeneID" id="20678591"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_62256"/>
    <dbReference type="eggNOG" id="KOG0177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_12_1_1"/>
    <dbReference type="InParanoid" id="W4KES7"/>
    <dbReference type="OrthoDB" id="268428at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000008">
        <property type="entry name" value="Proteasome subunit beta type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW83576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="194" mass="21904" checksum="C49DF03E9E0D98DB" modified="2014-03-19" version="1">MDCSFALTGKDYVIIAADTTAARSIVKMKVDEDKIKTLSPHLLMAYSGEPGDTVQFAEYVERNLRLYHIRNLYPLRPQSAAAWIRRALADSLRSRHPYNVNILLGGYDTADDKPQLYWMDYLGTLASVPFAAHGYGSYFTLGLFDKYHNPNASLEEGLETLKRAIDETSRRLVVAPGKYKVKIVDKNGVREIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEZ2</accession>
    <name>W4KEZ2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_471885</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543409.1">
        <property type="nucleotide sequence ID" value="XM_009545114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEZ2"/>
    <dbReference type="STRING" id="747525.W4KEZ2"/>
    <dbReference type="GeneID" id="20677419"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_471885"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_34_23_1"/>
    <dbReference type="InParanoid" id="W4KEZ2"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="139"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="645"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="678"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="714"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="744"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW83636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="833" mass="92525" checksum="9D28AE8A5D97D268" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEZ6</accession>
    <name>W4KEZ6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aspartic peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_123912</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543969.1">
        <property type="nucleotide sequence ID" value="XM_009545674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEZ6"/>
    <dbReference type="FunCoup" id="W4KEZ6">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="GeneID" id="20666845"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_123912"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_1_4_1"/>
    <dbReference type="InParanoid" id="W4KEZ6"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF57">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844198" evidence="5">
        <location>
            <begin position="19"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="94"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="125"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW84284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="389" mass="40563" checksum="6168F65C2B256971" modified="2014-03-19" version="1">MRLLFAVVVSTLSLIASASPVFRVGITVPLTRHVRFANGNGVSNMTLLHSHLAAVQGKLRRGFEAFKQNTGTQHPSDNGHLHKRATGADKLTDNEGALWQGGISVGNPAKDFTGSSDLFLPGTDCTVNCEGHTLYDPDASSESSDTDTPFSLAFGDESTVQGTVFRDTGTIAGLTANKQAINDANRFSAGFAIDELPPDGLLGMAFPQISVFGENPFFQTLVAQGTVTAPEFAFKLATSGSELFSGGVNDNLFTGSFTELPVTTAGFWEVDLDSVNANGDTAVTGLSAIIDTGTTLIVGDADTVAQFYASVPAPCASVPNVSLTFGGTDFPMSADTFNLGPLSARSSQCVGGIAAADLGPFWVVGDIFLQNVYTSFDVGNTRVAFATLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KG84</accession>
    <name>W4KG84_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_312271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543984.1">
        <property type="nucleotide sequence ID" value="XM_009545689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KG84"/>
    <dbReference type="GeneID" id="20669940"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_312271"/>
    <dbReference type="eggNOG" id="ENOG502S9PZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101084_1_0_1"/>
    <dbReference type="InParanoid" id="W4KG84"/>
    <dbReference type="OrthoDB" id="3356019at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14514" checksum="5E0336C1BEF062F7" modified="2014-03-19" version="1">MSSAHAQRARRREEVDQAYRLQVRAGMVGAAQYGAFGLGLATITHHSWPFFRRQTLAFKGFLVSCITIYGLVTAADEALLSHEHKQRLEETHLRREARIDLARRGMVATETEISKWKAEREAQAGHPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGV5</accession>
    <name>W4KGV5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zona occludens toxin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_473230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544207.1">
        <property type="nucleotide sequence ID" value="XM_009545912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGV5"/>
    <dbReference type="GeneID" id="20677502"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_473230"/>
    <dbReference type="eggNOG" id="ENOG502QQSW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015256_4_0_1"/>
    <dbReference type="InParanoid" id="W4KGV5"/>
    <dbReference type="OrthoDB" id="2316594at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="HELICASE MJ1565-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957:SF1">
        <property type="entry name" value="HELICASE MJ1565-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW84550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="53783" checksum="B08C841CDC432C3A" modified="2014-03-19" version="1">MPTPLVKASDYGATSHSAVDFDLKDESLLLNNLSFNTDSGESETHELRTAPIFTREAYLEANLGKNVLQYGVLGTIMSIRSPSGAQSPPTDRRLYVNTNAPFSAVVCGVQGSGKSHTVSVLLESMFIPNCPATGELKKPLSGLVLHFGETGSSSRPCEVAFLGASQYRGVQPPDIRVYVSPSSLNRMTALYAPLGKRVQVEPLYLSESELDASAFLSMMAIGSSEAAPLYIQTVKAILRTLGEKYTYTKFLNILETKKKTFNPAQLSGIQQRLDLLMSFTSPNIPKTASKSRFCEGRITIIDLSDPFIDSSSACGLFEILLRLFERADVSTGKVLVVDEAHKYLSESRAASGLTKALLTLIRQQRHMAMRVVLSTQEPTIIPPVFIELSSLAIMHRFSSSAWWNHLAKHVSADLSGHDTFDQIVKLKTGEAIVLAPSGLAILEENNPSTGASNGTKRRLGQLGRRSLLIKTRKRVTKDGGMSILTVDGTYGFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4KH63</accession>
    <name>W4KH63_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_470236</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542057.1">
        <property type="nucleotide sequence ID" value="XM_009543762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KH63"/>
    <dbReference type="GeneID" id="20677338"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_470236"/>
    <dbReference type="HOGENOM" id="CLU_074158_0_0_1"/>
    <dbReference type="InParanoid" id="W4KH63"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW85182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="288" mass="31262" checksum="359958F2A094EC96" modified="2014-03-19" version="1">MARDIVEAPRDTVLRVLAEVPPQVLVEEAPELVPELPPSPETASEPVLLEHHVHVEEEPRQKKAKNGEGRDGREEGASQGASGATAGRRIVKRPRMPPIAGYGRFSVKLPSDYAERERETAGERGQMLVVHPQAHGSAPQQTTLTSTTSTYRVENPTSDPVPEAVLQSIGGPWTSTPGEEQRGARKRKRADPHVCDGTDGCRKRLSCPYDMPRHKATLRHGGQREFACGDCPALFVRKDEVHRHKREHCPNRGRKHSGEDGPSQGPRHDGPEGGGGGMEGIGDGLLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHW7</accession>
    <name>W4KHW7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_310038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542144.1">
        <property type="nucleotide sequence ID" value="XM_009543849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHW7"/>
    <dbReference type="GeneID" id="20669740"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_310038"/>
    <dbReference type="HOGENOM" id="CLU_1514079_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHW7"/>
    <dbReference type="OrthoDB" id="2832808at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="198" mass="22338" checksum="138D8B5E525B4325" modified="2014-03-19" version="1">MALPPRLVTPAKLIFEAANKANVTAVLFGGAAAKLHGAKRDTKDLDINVSSLAFTTLLPNEFVCHPRTVDTRQHITWANTVKCDVATERTELVNDAFETYSCVTEDGIRYASANILLADKIRTYGQRPFQAVQKQYNDLDDVLQLIDVMRQKGDKMPDELKESILSEDVLRAFFERVPIEDHLVYRTFLEELDVVLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHX9</accession>
    <name>W4KHX9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_314300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544324.1">
        <property type="nucleotide sequence ID" value="XM_009546029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHX9"/>
    <dbReference type="STRING" id="747525.W4KHX9"/>
    <dbReference type="GeneID" id="20670108"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_314300"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001324_5_7_1"/>
    <dbReference type="InParanoid" id="W4KHX9"/>
    <dbReference type="OrthoDB" id="2272314at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="2">
        <location>
            <begin position="451"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW84686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="625" mass="72373" checksum="0B2480798B3C185E" modified="2014-03-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KI52</accession>
    <name>W4KI52_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_438307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542374.1">
        <property type="nucleotide sequence ID" value="XM_009544079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KI52"/>
    <dbReference type="GeneID" id="20675039"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_438307"/>
    <dbReference type="HOGENOM" id="CLU_2256423_0_0_1"/>
    <dbReference type="InParanoid" id="W4KI52"/>
    <dbReference type="OrthoDB" id="2017782at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="104" mass="11795" checksum="7F995700A9240AE9" modified="2014-03-19" version="1" fragment="single">MVACIDCSTLFDTPVFPPRKVSLPYALLHSFEDKIADEDLALSLNSPMLEWPSFFISFFTSQFAACFFFSASFDSSFLPSSLYLCIHKQGCKKWPTNIIDGFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIH4</accession>
    <name>W4KIH4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_149305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
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                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
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                <person name="Karlsson M."/>
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                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Solheim H."/>
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                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
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    </evidence>
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</entry>
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    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="56" mass="6605" checksum="39818A7B34A09D39" modified="2014-03-19" version="1" fragment="single">HPVFHATMLTKYRETKAHGENFARPLPEVLNNKEHYKVETIVDLKKQGWGIKYLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJ29</accession>
    <name>W4KJ29_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_311241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542666.1">
        <property type="nucleotide sequence ID" value="XM_009544371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJ29"/>
    <dbReference type="FunCoup" id="W4KJ29">
        <property type="interactions" value="169"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KJ29"/>
    <dbReference type="GeneID" id="20669853"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_311241"/>
    <dbReference type="eggNOG" id="KOG1116">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013399_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJ29"/>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF31">
        <property type="entry name" value="ACYLGLYCEROL KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="82"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="443" mass="48577" checksum="0C7E2D4F920EE962" modified="2014-03-19" version="1" fragment="single">VPLQRVLWADSSESGTVVHVLAKKSERRGLVLVKAEGNAKKGASDELAREWSKLLMDAAYAGKSSTCIGRVPFKSLACIGVKQQRRFKIFINPNSGPGNAKTLYKRKVEPILKACRCSLDITFTERRNHAADIAAKLPLDEFDALLTVSGDGMVHEVFNGLAAHKDPLKALDIPIVPMPAGSGNGTSINLLGIEEGLDISAAALNAVKGRPMKVDLCSILQNGKRSFSFMSQCVGLMADLDLGTEHLRWMGSNRFVYGYLRGILTRRICPVSVSIKAIETDKVKMVEALNSFVPQTTINENSSLPEVGCASEDTDGWITFEQPLIYLYAGKGPYVGRDLMQFPMSVPNDGTIDIVIQGLVSRGELLDAMDGADMGKTFWRESSHYFKAQAYRVKPLSKNGYLAIDGEKFPFDEYLIEVHRGLGTVMSMYGQYVANFNVPRPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJ50</accession>
    <name>W4KJ50_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Imidazoleglycerol-phosphate dehydratase</fullName>
            <ecNumber evidence="4 9">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_145891</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="4 9"/>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542569.1">
        <property type="nucleotide sequence ID" value="XM_009544274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJ50"/>
    <dbReference type="FunCoup" id="W4KJ50">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KJ50"/>
    <dbReference type="GeneID" id="20667105"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_145891"/>
    <dbReference type="eggNOG" id="KOG3143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044308_3_0_1"/>
    <dbReference type="InParanoid" id="W4KJ50"/>
    <dbReference type="OrthoDB" id="447729at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000004">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000001">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="entry name" value="Imidazole glycerol phosphate dehydratase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002111">
        <property type="entry name" value="PRK00951.2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002114">
        <property type="entry name" value="PRK00951.2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133:SF2">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE HIS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW85739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="201" mass="21881" checksum="C125D545282C101A" modified="2014-03-19" version="1">MAERKATISRKTNETEIEVSINLDCQPGSTSQQVIEVSTGIGFLDHMYHALAKHSGISLTLKAKGDLWIDDHHTAEDTAIALGTAFKEALGEVRGIRRYGTGFAPLDEALSRAVIDICARPYCVTDLGIKREKIGDLSTEMFPHIFYSFAMASGCTLHVDVLRGENDHHRAESAFKALALAIRQAIERTGGNDVPSTKGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJ90</accession>
    <name>W4KJ90_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_379299</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009543949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJ90"/>
    <dbReference type="GeneID" id="20671963"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_379299"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015676_1_0_1"/>
    <dbReference type="InParanoid" id="W4KJ90"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="ETW85380.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000030671"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="67721" checksum="B76ACCF4B2D3B7F9" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJE4</accession>
    <name>W4KJE4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_414787</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
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                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
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                <person name="Park J."/>
                <person name="Raffaello T."/>
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                <person name="Velez H."/>
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                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009544331.1"/>
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    <dbReference type="STRING" id="747525.W4KJE4"/>
    <dbReference type="GeneID" id="20673201"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_414787"/>
    <dbReference type="eggNOG" id="ENOG502SH1N">
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    <dbReference type="InParanoid" id="W4KJE4"/>
    <dbReference type="OrthoDB" id="3261594at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="244" mass="27540" checksum="AE10847677BC89CE" modified="2014-03-19" version="1">METILAELHILGKLAVFDDILHGSDCWDAYQHGRYLPGDIVVMFSMDRAQLYKNKASDCWIYIWILVNLAPNKCYKKRYMMPRAIIPGPNKPKNIDLFMYPGLHHVAALQKEGFQVWDVSRRATNPSHPWIILVTADAVGASLLYRGVSHHGKKGCCKGCNKVGHRKPGGSHYYSACLKPDNYNEDGCNHSDDEPANLPVWSPEEYQDDCIQLQQSASIAKYEHRCLKTGISRPSIFSGMPSEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJV0</accession>
    <name>W4KJV0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_167632</name>
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    <organism evidence="8 9">
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009544618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJV0"/>
    <dbReference type="STRING" id="747525.W4KJV0"/>
    <dbReference type="GeneID" id="20668126"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_167632"/>
    <dbReference type="eggNOG" id="KOG4652">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014668_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJV0"/>
    <dbReference type="OrthoDB" id="1928087at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007130">
        <property type="term" value="P:synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051294">
        <property type="entry name" value="HORMA_MeioticProgression"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225">
        <property type="entry name" value="HORMA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225:SF7">
        <property type="entry name" value="MEIOSIS-SPECIFIC PROTEIN HOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="7">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="305"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="394"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="636"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="714"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="642"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="719"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW86143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="791" mass="87985" checksum="233CA1517812C99E" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJW9</accession>
    <name>W4KJW9_HETIT</name>
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        <recommendedName>
            <fullName evidence="5">Tuberous sclerosis 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_414974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJW9"/>
    <dbReference type="STRING" id="747525.W4KJW9"/>
    <dbReference type="GeneID" id="20673214"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_414974"/>
    <dbReference type="eggNOG" id="ENOG502R01W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007465_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJW9"/>
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    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="298"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="622"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="720"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW85999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="886" mass="101437" checksum="3745D0C788436133" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJZ8</accession>
    <name>W4KJZ8_HETIT</name>
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        <submittedName>
            <fullName evidence="14">Metallo peptidase M16B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_31896</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M16 family.</text>
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    <dbReference type="OrthoDB" id="952271at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="10">
        <location>
            <begin position="4"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="11">
        <location>
            <begin position="212"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="12">
        <location>
            <begin position="398"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="13">
        <location>
            <begin position="797"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW86188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1066" mass="120319" checksum="EEC852AA9EAAB15E" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KK87</accession>
    <name>W4KK87_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Metallo peptidase M13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_32392</name>
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    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541741.1">
        <property type="nucleotide sequence ID" value="XM_009543446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KK87"/>
    <dbReference type="STRING" id="747525.W4KK87"/>
    <dbReference type="GeneID" id="20671004"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_32392"/>
    <dbReference type="eggNOG" id="KOG3624">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006187_2_0_1"/>
    <dbReference type="InParanoid" id="W4KK87"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="11">
        <location>
            <begin position="151"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="10">
        <location>
            <begin position="632"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW85740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="845" mass="94130" checksum="4411EA1F7C7C83A8" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4KK92</accession>
    <name>W4KK92_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_309211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543024.1">
        <property type="nucleotide sequence ID" value="XM_009544729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KK92"/>
    <dbReference type="GeneID" id="20669654"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_309211"/>
    <dbReference type="HOGENOM" id="CLU_2688111_0_0_1"/>
    <dbReference type="InParanoid" id="W4KK92"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="74" mass="8439" checksum="112C4D30DDD66954" modified="2014-03-19" version="1">MLVILESKLTYVCCEVSPITHLRATSSRQGCFQTAVRDHQSYWRTRKPSPLSAIFYSGTVGQVLYICIETGRFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKJ4</accession>
    <name>W4KKJ4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_243182</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COA8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542672.1">
        <property type="nucleotide sequence ID" value="XM_009544377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKJ4"/>
    <dbReference type="GeneID" id="20668969"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_243182"/>
    <dbReference type="eggNOG" id="ENOG502SD1P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120079_0_0_1"/>
    <dbReference type="InParanoid" id="W4KKJ4"/>
    <dbReference type="OrthoDB" id="6246201at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097193">
        <property type="term" value="P:intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018796">
        <property type="entry name" value="COA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31107">
        <property type="entry name" value="APOPTOGENIC PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31107:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10231">
        <property type="entry name" value="COA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW85860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="175" mass="19690" checksum="1B69791F23DD3515" modified="2014-03-19" version="1" fragment="single">RSRPRLLSTTAPVHDLIGPSDPLSNLRPVIYTDGPSSSSSSSPSPSPPAIRRHPYSLTEFRLRTKAPGAREVGPGAEPALAYRWRLQKQQLDAFNHAFWADSNARFDASLASAVAGTAPSSPQHERALNAFYGRWVHAEAVRQEEYNREWRRRSVEEIKLAFRVSWQRLLARFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKR4</accession>
    <name>W4KKR4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Formate dehydrogenase</fullName>
            <shortName evidence="5">FDH</shortName>
            <ecNumber evidence="2 5">1.17.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NAD-dependent formate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_380119</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>formate + NAD(+) = CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:15985"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.9" evidence="2 5"/>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542741.1">
        <property type="nucleotide sequence ID" value="XM_009544446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKR4"/>
    <dbReference type="STRING" id="747525.W4KKR4"/>
    <dbReference type="GeneID" id="20672005"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_380119"/>
    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_0_0_1"/>
    <dbReference type="InParanoid" id="W4KKR4"/>
    <dbReference type="OrthoDB" id="418179at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042183">
        <property type="term" value="P:formate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05302">
        <property type="entry name" value="FDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000057">
        <property type="entry name" value="Formate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03210">
        <property type="entry name" value="Formate_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033689">
        <property type="entry name" value="FDH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005750">
        <property type="entry name" value="PRK07574.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF9">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="7">
        <location>
            <begin position="32"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="8">
        <location>
            <begin position="127"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="172"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="228"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="309"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW85940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="358" mass="39535" checksum="0D02174D52E2DE07" modified="2014-03-19" version="1">MKVLAILYNGYKAAEEEPRLLGTVENQLGIREYLESLGHEYIVSSSKEGPDSDFQRHIVDADVLITTPFHPGYLTRELMEKAKNLKICVTAGVGSDHIDLNAAVERKIQVLEVSGSNVVSVAEQVLMSILLLVRNFVPAHEMIERGDWQVSDIARNAYDLEGKVVGTLGAGRIGYRVLQRLVPFNCKELIYFDYNPLPAEAEKAVNARRVQDMKEFVSQCDIVTINAPLHEGTLGLINKELLQHFKKGAWLVNTARGAICNADDVAEAIRSGQLNGYAGDVWNVQPAPKDHPWRTVKNPFGGGNGMTPHYSGTTLDAQARYAQGTKTILQNFFEGKPQDPGNVIVGIGKYETKAYGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLE5</accession>
    <name>W4KLE5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_309516</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542945.1">
        <property type="nucleotide sequence ID" value="XM_009544650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLE5"/>
    <dbReference type="FunCoup" id="W4KLE5">
        <property type="interactions" value="432"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KLE5"/>
    <dbReference type="GeneID" id="20669684"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_309516"/>
    <dbReference type="eggNOG" id="KOG0106">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_34_2_1"/>
    <dbReference type="InParanoid" id="W4KLE5"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12339">
        <property type="entry name" value="RRM2_SRSF1_4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF51">
        <property type="entry name" value="SERINE-ARGININE PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="3"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="96"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="166"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW86180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="296" mass="35001" checksum="4D28EDD8293BF59B" modified="2014-03-19" version="1">MARRLYLGKLPPDTRTDDVSKFFDGYGKIVDCRVMTGFGFVEFESSRDAEDAMHHFNGKNFMGSSIVVEFAKESRPRRDPYDDRYGAPRVRRPPGIRITVTGISRDTSWQDLKDFGREAGSVSFADIDRDNVGTGILEYIAREDADRAVKELDGKDLRGQSVRVALQEDRGPDNYRRDDRRVDDRYRDDRYRDDRHRDDRHERSYRDDKPYRRERSRSPARRGDVDDRRPRSPPPRRDLDDRRPAGYDDRRGGYDDRRGPDPYYDRRRDDRRRDEKDDRIDDRVSSRHANGDGGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLR9</accession>
    <name>W4KLR9_HETIT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_246983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543055.1">
        <property type="nucleotide sequence ID" value="XM_009544760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLR9"/>
    <dbReference type="GeneID" id="20669137"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_246983"/>
    <dbReference type="eggNOG" id="ENOG502ST30">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1801052_0_0_1"/>
    <dbReference type="InParanoid" id="W4KLR9"/>
    <dbReference type="OrthoDB" id="2678231at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="144" mass="16495" checksum="19345F7D9BCFD25B" modified="2014-03-19" version="1" fragment="single">EEPGTISDDDDDDDWDEEKTLVAFLHDRGIEDSESPAPSALVDKLGPAFARSSKRAKQDVVDSLLPAMRRIRTVHEKLSEDTDRGIAAGVLEIDNACKHFEEVQLQREEELSRALSETQVRLKKLFSDLQKRYKLREQLRIDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLT7</accession>
    <name>W4KLT7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6830 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_305827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540682.1">
        <property type="nucleotide sequence ID" value="XM_009542387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLT7"/>
    <dbReference type="GeneID" id="20669351"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_305827"/>
    <dbReference type="eggNOG" id="ENOG502SHSB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006344_10_2_1"/>
    <dbReference type="InParanoid" id="W4KLT7"/>
    <dbReference type="OrthoDB" id="3232986at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049233">
        <property type="entry name" value="DUF6830"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20722">
        <property type="entry name" value="DUF6830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6830" evidence="1">
        <location>
            <begin position="747"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1009" mass="112778" checksum="FFBD714520E8A33E" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMX4</accession>
    <name>W4KMX4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T2</fullName>
            <ecNumber evidence="2">4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Rnase_T2_2</name>
        <name evidence="7" type="ORF">HETIRDRAFT_40579</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the RNase T2 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.19" evidence="2"/>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540308.1">
        <property type="nucleotide sequence ID" value="XM_009542013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMX4"/>
    <dbReference type="GeneID" id="20672516"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_40579"/>
    <dbReference type="eggNOG" id="KOG1642">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037966_2_0_1"/>
    <dbReference type="InParanoid" id="W4KMX4"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018188">
        <property type="entry name" value="RNase_T2_His_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF17">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00530">
        <property type="entry name" value="RNASE_T2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844369" description="ribonuclease T2" evidence="6">
        <location>
            <begin position="20"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012571"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR633697-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW87059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="306" mass="34054" checksum="0FCCFCBB0C89233C" modified="2014-03-19" version="1">MPVHYGLLTLLAVSSACYASSSQFSFVPNTFPNISACVNQPPTFSCENTTTITNTCCSPTPGGLVLQTQFWNTYTGFERQGQLLPKNSWTIHGLWPDNCDGSYEQYCDLSRQYDPNPSPAVLPDGTVVPPYNGPGLGTFVEEFGRWDLLDFMNKYWVSQGSLNSDFWGHEFSKHATCTSTFDLTCYGPDYKKHQDTVDFFLAVVRAFKMFPTFDTLAASGIIPSNKTTYSLSHIQNALKAQTGSIPFIGCGHNGTVLQEIWYFNHVMGTEQFGSFKSVDSTTKSSCSNTTGINYYERTPTSEREVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNW7</accession>
    <name>W4KNW7_HETIT</name>
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        <recommendedName>
            <fullName evidence="2">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">HETIRDRAFT_59470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">TC 32-1</strain>
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    </reference>
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        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
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        <property type="nucleotide sequence ID" value="XM_009542115.1"/>
    </dbReference>
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    <dbReference type="STRING" id="747525.W4KNW7"/>
    <dbReference type="GeneID" id="20678476"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_59470"/>
    <dbReference type="eggNOG" id="KOG0805">
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    </dbReference>
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    <dbReference type="OrthoDB" id="10250282at2759"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF1">
        <property type="entry name" value="CN HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="5"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW87389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="315" mass="34541" checksum="81D4C4AD85EFB47E" modified="2014-03-19" version="1">MSNTIRASVVQTCTAAYSLSNTLDKLERLTRLAKDRDGSKLAVFPEAFIGGYPKMMTFGAVVGERSVQGRDEFLRYYNAAIELPSPALSRIETISRETDVFLVIGIIERDGGTLYCTAIFVDPIDGFVGKHRKLMPTASERLIWGQGGPDTIAVHTKQFPSVGQSDVHVNTKISAAICWENYMPLLRTHYYSQGTQLYCAPTVDARPVWQSTMTHIAIEGRCFVLSACQFSQEKDFPEDHAVADPSARNAENVMIAGGSVIINPLGKVLAGPLLNGEGVLTAELDLDDIARGKFDLDVVGHYARHDIFKLEVIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4KP84</accession>
    <name>W4KP84_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_413196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540822.1">
        <property type="nucleotide sequence ID" value="XM_009542527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KP84"/>
    <dbReference type="GeneID" id="20673096"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_413196"/>
    <dbReference type="eggNOG" id="ENOG502S8P6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003032_0_0_1"/>
    <dbReference type="InParanoid" id="W4KP84"/>
    <dbReference type="OrthoDB" id="2526154at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1145"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
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        <location>
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            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="686"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
    </feature>
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        <location>
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            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="917"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="957"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1077"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1145"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1184"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1198"/>
            <end position="1214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1256" mass="135705" checksum="1F1ABA3FB047DCEA" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPA7</accession>
    <name>W4KPA7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="7">3.4.21.92</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_31617</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="7"/>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540301.1">
        <property type="nucleotide sequence ID" value="XM_009542006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPA7"/>
    <dbReference type="STRING" id="747525.W4KPA7"/>
    <dbReference type="GeneID" id="20670295"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_31617"/>
    <dbReference type="eggNOG" id="KOG0840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058707_3_1_1"/>
    <dbReference type="InParanoid" id="W4KPA7"/>
    <dbReference type="OrthoDB" id="2017408at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009368">
        <property type="term" value="C:endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381:SF11">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW87647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="178" mass="19152" checksum="FA7F31136AC435AE" modified="2014-03-19" version="1">MLYGPIRDTDSALIVAQLLFLEAEETSKPIHLYINSPGGSVTAGLAIYDTVRYVSSPIHTYCVGQASSMGSLLLAAGENGKRHCLPNASIMIHQPSGGASGQASDIAIHAKEILRIRKLLTGIYQKHCAQSGESEEAGVQRFETALERDYFMTAQEALAFGIVDGILEKRPKFDGDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPC7</accession>
    <name>W4KPC7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_413871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541449.1">
        <property type="nucleotide sequence ID" value="XM_009543154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPC7"/>
    <dbReference type="GeneID" id="20673138"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_413871"/>
    <dbReference type="HOGENOM" id="CLU_1796713_0_0_1"/>
    <dbReference type="InParanoid" id="W4KPC7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW87559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="144" mass="16071" checksum="E8090DD38C262B61" modified="2014-03-19" version="1">MGDGWRGARLTADCDRSEIGAGHVQIQLVGGVHKLLFPLFAVYHLHDDRSFLCLSTSLIDIISRYTTLGRVQSASEFGHDVWSTTEYGIYWQLPPREGHVVIKSWDIFPLHSSHLPLHTRLILQHASSCNPPPGRALSALTSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPE4</accession>
    <name>W4KPE4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_431969</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541580.1">
        <property type="nucleotide sequence ID" value="XM_009543285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPE4"/>
    <dbReference type="FunCoup" id="W4KPE4">
        <property type="interactions" value="153"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KPE4"/>
    <dbReference type="GeneID" id="20674580"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_431969"/>
    <dbReference type="eggNOG" id="KOG4155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012350_0_0_1"/>
    <dbReference type="InParanoid" id="W4KPE4"/>
    <dbReference type="OrthoDB" id="496at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF28">
        <property type="entry name" value="CCR4-ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="361"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="450"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="551"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="574"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="654"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="274"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW87713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="685" mass="75583" checksum="688188BD18FBDE8F" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPM7</accession>
    <name>W4KPM7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">WD repeat-containing protein 75 second beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_307124</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540960.1">
        <property type="nucleotide sequence ID" value="XM_009542665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPM7"/>
    <dbReference type="FunCoup" id="W4KPM7">
        <property type="interactions" value="577"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KPM7"/>
    <dbReference type="GeneID" id="20669461"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_307124"/>
    <dbReference type="eggNOG" id="KOG1963">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005417_1_0_1"/>
    <dbReference type="InParanoid" id="W4KPM7"/>
    <dbReference type="OrthoDB" id="4096at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057644">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23869">
        <property type="entry name" value="Beta-prop_WDR75_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23769">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="130"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="330"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="WD repeat-containing protein 75 second beta-propeller" evidence="10">
        <location>
            <begin position="457"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW87006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="960" mass="104716" checksum="A9D0C3A518780E87" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPN4</accession>
    <name>W4KPN4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_99999</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541548.1">
        <property type="nucleotide sequence ID" value="XM_009543253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPN4"/>
    <dbReference type="FunCoup" id="W4KPN4">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KPN4"/>
    <dbReference type="GeneID" id="20678928"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_99999"/>
    <dbReference type="eggNOG" id="KOG0682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_1"/>
    <dbReference type="InParanoid" id="W4KPN4"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF4">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="21"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="471"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW87679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="513" mass="54883" checksum="A140C29D276440B9" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPW1</accession>
    <name>W4KPW1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_41624</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540343.1">
        <property type="nucleotide sequence ID" value="XM_009542048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPW1"/>
    <dbReference type="GeneID" id="20673302"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_41624"/>
    <dbReference type="eggNOG" id="ENOG502QPVD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028452_3_0_1"/>
    <dbReference type="InParanoid" id="W4KPW1"/>
    <dbReference type="OrthoDB" id="546893at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF3">
        <property type="entry name" value="PROTEIN TSGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW87096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="45157" checksum="A4B3884607F25FB9" modified="2014-03-19" version="1" fragment="single">SELSFARWAFAFALVTSLFFTWGFAYGLLDVLNSHFQTVFGISKLQSTLLQLAYFVRIIVLCVGAIRGNMRRYGYKKGIHLGLTLYSLGAVFFWPSAKFEKYGGFVGSTFVIGCGLATLEVAANSYISVLGTPQYAAMRLNFSQGFQGLASFAGPLIASTYFFKGKNANSLTNVQWVYLAVAALGLVLNILFFFCDLPEITEEALEKEIEDAGLVEDDIGPFWKQYRCIFGFVAQMAYCGAQITVASFVVNYLTEQGVGIDHSRASLMFSFCQLTFTGGRFIGVVLLKWLDPALVLSAYGIACCAFCLGVALAGGNGGIACLFLLFFFESICYPCIFTLGTKNLGVHTKRGSGLIVMGVGGGAWYPPAQGALADKTFTRHSYLVPFSGYVAMSAYAMYVPSLPTDSGDADRKAFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4KQC7</accession>
    <name>W4KQC7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_167172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541488.1">
        <property type="nucleotide sequence ID" value="XM_009543193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KQC7"/>
    <dbReference type="GeneID" id="20668105"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_167172"/>
    <dbReference type="HOGENOM" id="CLU_2441123_0_0_1"/>
    <dbReference type="InParanoid" id="W4KQC7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW87605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="90" mass="9444" checksum="B9FDA1951DE43CB7" modified="2014-03-19" version="1">MVEEVQALLTGGEETVGAERGRWTGREGTAVVVEDRWTGNGAMVAVEEDLSIGSEATGVEAVALSTGEERTVAVVLDRWIGSQLVISQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4JM73</accession>
    <name>W4JM73_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_412654</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553147.1">
        <property type="nucleotide sequence ID" value="XM_009554852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JM73"/>
    <dbReference type="STRING" id="747525.W4JM73"/>
    <dbReference type="GeneID" id="20673054"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_412654"/>
    <dbReference type="eggNOG" id="ENOG502S50U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058846_1_0_1"/>
    <dbReference type="InParanoid" id="W4JM73"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="4">
        <location>
            <begin position="56"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW74652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="303" mass="31435" checksum="A108001B7EBEEF42" modified="2014-03-19" version="1">MSAIATDPPTLPAPFSPDAVAGLCLHEPKYFKVQLQSTAHRAAIIAHWVIPAGARVLEIGCGQGDTTAVLAELVGEAGHVTGVDPGALDYGAPFTLGQAQAHLSAGPLGPRITWAHADPLAFLAARAPDAPPFDVAVLSLCTWYFASPRVLSALLAALAPHATRLCVAEWSLSAARPAAHAHVLAALAQAALEHRNPASESNVRTAFAPASIVRAAAAPEGGAWTVVSEGRFRPAEGTLDGQWEVQAVLGGGFERGIEEFVKDEGERAVVVALREAVRAAADVVGGPKKVEAMDVWCAEFVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMW9</accession>
    <name>W4JMW9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HETIRDRAFT_332035</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553366.1">
        <property type="nucleotide sequence ID" value="XM_009555071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JMW9"/>
    <dbReference type="FunCoup" id="W4JMW9">
        <property type="interactions" value="455"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JMW9"/>
    <dbReference type="GeneID" id="20671698"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_332035"/>
    <dbReference type="eggNOG" id="KOG0338">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_3_2_1"/>
    <dbReference type="InParanoid" id="W4JMW9"/>
    <dbReference type="OrthoDB" id="10259843at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17947">
        <property type="entry name" value="DEADc_DDX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="233"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="435"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="64"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="654"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="713"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="95"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="654"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="752"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="777"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETW74902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="792" mass="87677" checksum="F0C98A40E39DFBA2" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNT6</accession>
    <name>W4JNT6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_442683</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553213.1">
        <property type="nucleotide sequence ID" value="XM_009554918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNT6"/>
    <dbReference type="GeneID" id="20675477"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_442683"/>
    <dbReference type="eggNOG" id="ENOG502T160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094660_1_0_1"/>
    <dbReference type="InParanoid" id="W4JNT6"/>
    <dbReference type="OrthoDB" id="3267106at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004843789" description="CFEM domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="7">
        <location>
            <begin position="72"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW74725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="236" mass="22918" checksum="8CAEA16B12FEE801" modified="2014-03-19" version="1">MLALPCSLVFLLLFALVSAQSSSSVPSSSARSASASQSSSASASNVPSASVTRTLTSVTLTDASGLTTIIPITVTPSSSASHSGSATSTASFPSLTGYSSCVVDCLTHAVSAANCSSVTDVNCFCESSVFPPSYESCVETSCASDLPSATSLANQFCAVSSPSTSISFTSPTSTPTSSGSSTRPSSSTPSSTTSQSASSSASSNAAAAQRGIGGTQGGLATAGISILGSILGALLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPU3</accession>
    <name>W4JPU3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_412616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552988.1">
        <property type="nucleotide sequence ID" value="XM_009554693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPU3"/>
    <dbReference type="GeneID" id="20673044"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_412616"/>
    <dbReference type="HOGENOM" id="CLU_2688124_0_0_1"/>
    <dbReference type="InParanoid" id="W4JPU3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="79" mass="8746" checksum="F7487F2F65F719C3" modified="2014-03-19" version="1">MRARATPRRQEPAFACDPQPPARPLDPTPVSSSPRSLATECLRLHQPLGPTHPSSPATYIRTRASRQAHARMLEPSTYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQG0</accession>
    <name>W4JQG0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cup1</name>
        <name evidence="2" type="ORF">HETIRDRAFT_331039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552741.1">
        <property type="nucleotide sequence ID" value="XM_009554446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQG0"/>
    <dbReference type="STRING" id="747525.W4JQG0"/>
    <dbReference type="GeneID" id="20671630"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_331039"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_10_2_1"/>
    <dbReference type="InParanoid" id="W4JQG0"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="1">
        <location>
            <begin position="93"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="264" mass="30703" checksum="DC9DDBDC3ED9ED0F" modified="2014-03-19" version="1">MSWVDPWLECAQHIANGVRDRIEHYNLNRNVYLKEHPTAVRPLLPEIQSFIRFNHIEVVQELARLLALGLELPEDALVQKLSYEDKNNAYCRFMMYHPRPEEEEVKTDQVWLKGHPDQTLMSVLWSQPVSALQIRDSDGKWRWVKHVENALVVNCGDSLDMLSGAYYKSAIHRVIRPPEDQRGHNRLGVFYFCYADDDVQLEPLIDSPVLQRVGITRRVPEGKAPFMEAWRKARTAAYGTSDLKKGLEDVEEEILEGIRVKHYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQK7</accession>
    <name>W4JQK7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWR1-complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_329856</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552059.1">
        <property type="nucleotide sequence ID" value="XM_009553764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQK7"/>
    <dbReference type="STRING" id="747525.W4JQK7"/>
    <dbReference type="GeneID" id="20671525"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_329856"/>
    <dbReference type="eggNOG" id="KOG4776">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083063_0_0_1"/>
    <dbReference type="InParanoid" id="W4JQK7"/>
    <dbReference type="OrthoDB" id="445677at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011421">
        <property type="entry name" value="BCNT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407:SF1">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07572">
        <property type="entry name" value="BCNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51279">
        <property type="entry name" value="BCNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCNT-C" evidence="4">
        <location>
            <begin position="86"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW75808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="170" mass="18982" checksum="04FB0637B97DB1ED" modified="2014-03-19" version="1">MIMIEKKYRFAGEDVIEVKEVAADSEEARKWPVWQSPESNDKASPIAAVEPAASTFPESNAGVDTSQHPVAPPPPQPLAGKKPVRRKPKVQLAALPSSSAQKPKKLTTLEKSAIDWQAHVGSQEDPQLQDELEANRRTGGYLEKMQFLQRVEDRKDQAFDASRDKKRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQP8</accession>
    <name>W4JQP8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_181277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552039.1">
        <property type="nucleotide sequence ID" value="XM_009553744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQP8"/>
    <dbReference type="STRING" id="747525.W4JQP8"/>
    <dbReference type="GeneID" id="20668606"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_181277"/>
    <dbReference type="eggNOG" id="ENOG502RYNU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020536_0_0_1"/>
    <dbReference type="InParanoid" id="W4JQP8"/>
    <dbReference type="OrthoDB" id="5303367at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="59"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="543" mass="60991" checksum="7EFA16E1659682BC" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W4JR96</accession>
    <name>W4JR96_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_331291</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552812.1">
        <property type="nucleotide sequence ID" value="XM_009554517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JR96"/>
    <dbReference type="FunCoup" id="W4JR96">
        <property type="interactions" value="775"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JR96"/>
    <dbReference type="GeneID" id="20671646"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_331291"/>
    <dbReference type="eggNOG" id="KOG0861">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074848_0_1_1"/>
    <dbReference type="InParanoid" id="W4JR96"/>
    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15867">
        <property type="entry name" value="R-SNARE_YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000020">
        <property type="entry name" value="synaptobrevin homolog YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045848">
        <property type="entry name" value="R-SNARE_YKT6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="8"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="139"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW75391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="199" mass="22246" checksum="9F8542FF8816EBCE" modified="2014-03-19" version="1">MKIYSLAVVLSPPSGPSAILSQASDLSSFSFYQKGSVGEFMTFFTKTVAERTSQGQRQTVQENNYTAHVYNRGGAEQLSAVIVTDMEYPARPAFSLLTKILDEFTAKVPQSSFSNPSAISFPDINTYIQKYQDPRQADNIMRVQQELDETKIILHKTIESVLERGEKLDNLVERSTALSAQSKMFYKTAKKQNSCCSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRD3</accession>
    <name>W4JRD3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_329582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552249.1">
        <property type="nucleotide sequence ID" value="XM_009553954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRD3"/>
    <dbReference type="GeneID" id="20671504"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_329582"/>
    <dbReference type="eggNOG" id="ENOG502RVFF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_445530_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRD3"/>
    <dbReference type="OrthoDB" id="412109at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052671">
        <property type="entry name" value="Acrosomal_SP-10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17571:SF34">
        <property type="entry name" value="ACROSOMAL PROTEIN SP-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17571">
        <property type="entry name" value="URINARY PROTEIN RUP /ACROSOMAL PROTEIN SP-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="331"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW76024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="613" mass="71437" checksum="166BD9C5CAA5ED74" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRG9</accession>
    <name>W4JRG9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_106359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009553650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRG9"/>
    <dbReference type="GeneID" id="20666158"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_106359"/>
    <dbReference type="HOGENOM" id="CLU_2109364_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRG9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="115" mass="12931" checksum="7DD5E0B874D40098" modified="2014-03-19" version="1">MGPLSVRAQRAQPRSRSLNGRVCGKNPTRPTPRTPARAEAVPSVRIQSTERPQPASICLRPETAQDDLVPVQKRHEKQHEKRHESRAAPHQHRRSEGGWEVEAHDSPESTRSDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRJ8</accession>
    <name>W4JRJ8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_430485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552309.1">
        <property type="nucleotide sequence ID" value="XM_009554014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRJ8"/>
    <dbReference type="GeneID" id="20674449"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_430485"/>
    <dbReference type="HOGENOM" id="CLU_619726_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRJ8"/>
    <dbReference type="OrthoDB" id="2905268at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012384442" evidence="2">
        <location>
            <begin position="16"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW76089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="442" mass="48922" checksum="7A5123FFB63C7685" modified="2014-03-19" version="1">MFALFCLSMPSLSSARIGRWLAMTLWPFTLATACLGFQIWWTVTALVSHRAYPGGPDAWISQHGADAKNVVLNVFRRVWVARSAGSSLLVLSGQTYRSYVIFNHKPAVTVLPSEMFVATVVTGSLSLYNLTRSQVVEHEIANFAITYRTVSLSLSVILTSLITTRLLDIRREVGKLLSEDTGGRGLRSYTSVVAMLVGSASLETVTALVYICLLGVGRPLQDVFLPVLGQVRCLANEGISSRWGCYQTWERETTRTLIQQTHELPVAFSPKYKPKDFSFISRPGRETISGGGSPPTSALQRNSVHQEWQFSTTCLVFCRRADFHTVAFAAEQQGPGDEKSYDGHYVGSKHSFAEDVDYTQKIMDTDLLKARTAEVTHRVVGLEKRGALSLRVVERRDTAVAGGTREDRGPVFLATQMAAAGSRHCRQLQTHPDTSTTLRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRX7</accession>
    <name>W4JRX7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_390267</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552093.1">
        <property type="nucleotide sequence ID" value="XM_009553798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRX7"/>
    <dbReference type="FunCoup" id="W4JRX7">
        <property type="interactions" value="585"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JRX7"/>
    <dbReference type="GeneID" id="20672444"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_390267"/>
    <dbReference type="eggNOG" id="KOG2121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006220_3_1_1"/>
    <dbReference type="InParanoid" id="W4JRX7"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07718">
        <property type="entry name" value="RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027794">
        <property type="entry name" value="tRNase_Z_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13691">
        <property type="entry name" value="Lactamase_B_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNase Z endonuclease" evidence="13">
        <location>
            <begin position="6"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="12">
        <location>
            <begin position="729"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="159"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="217"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="875"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW75850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="898" mass="98431" checksum="A36008222BBFD4E9" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4JS64</accession>
    <name>W4JS64_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_436863</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552180.1">
        <property type="nucleotide sequence ID" value="XM_009553885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JS64"/>
    <dbReference type="GeneID" id="20674917"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_436863"/>
    <dbReference type="eggNOG" id="KOG0988">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003387_1_0_1"/>
    <dbReference type="InParanoid" id="W4JS64"/>
    <dbReference type="OrthoDB" id="10055769at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF14">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="254"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW75945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1198" mass="134544" checksum="630006A3CCF0B899" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSA9</accession>
    <name>W4JSA9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_429895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551336.1">
        <property type="nucleotide sequence ID" value="XM_009553041.1"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JSA9"/>
    <dbReference type="GeneID" id="20674389"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_429895"/>
    <dbReference type="eggNOG" id="ENOG502SKHB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002498_0_1_1"/>
    <dbReference type="InParanoid" id="W4JSA9"/>
    <dbReference type="OrthoDB" id="2687259at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1290"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1301"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1313"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1340"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1354"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1387"/>
            <end position="1399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1399" mass="158350" checksum="4B062A939280812D" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSJ6</accession>
    <name>W4JSJ6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_421979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551428.1">
        <property type="nucleotide sequence ID" value="XM_009553133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSJ6"/>
    <dbReference type="GeneID" id="20673767"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_421979"/>
    <dbReference type="HOGENOM" id="CLU_3143263_0_0_1"/>
    <dbReference type="InParanoid" id="W4JSJ6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="49" mass="5816" checksum="0E3B121CB0F0105D" modified="2014-03-19" version="1">MVCDLTQFYTIAWLSKSYIYYFFFIGSSIPVPATNTWIIYYKHSGFGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSU7</accession>
    <name>W4JSU7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_422752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552391.1">
        <property type="nucleotide sequence ID" value="XM_009554096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSU7"/>
    <dbReference type="GeneID" id="20673846"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_422752"/>
    <dbReference type="HOGENOM" id="CLU_2886080_0_0_1"/>
    <dbReference type="InParanoid" id="W4JSU7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="63" mass="7520" checksum="97D1F9B4BE42CEBD" modified="2014-03-19" version="1">MHIYFRRSAGQSRTIPPLEQLQQTITRRLRVSSAEHRDWIEARRPVLLGHIPMEFSSCVYRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4JT90</accession>
    <name>W4JT90_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 monooxygenase 89 like-protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cyp89</name>
        <name evidence="10" type="ORF">HETIRDRAFT_329228</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551559.1">
        <property type="nucleotide sequence ID" value="XM_009553264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JT90"/>
    <dbReference type="STRING" id="747525.W4JT90"/>
    <dbReference type="GeneID" id="20671477"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_329228"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2085137_0_0_1"/>
    <dbReference type="InParanoid" id="W4JT90"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW76679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="117" mass="13944" checksum="5EAA5F8E65F7DC7E" modified="2014-03-19" version="1" fragment="single">LPIFADYENLPYIQALIRETLRWNPIDPLDTYLMLKFQDDWYEGYFIPASTIYIDNMWDANVPEFKLEHYLDKQGRLVKAPVDTRDKGHIIFGFGRRICIERHLANNSLFINIAYML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTB7</accession>
    <name>W4JTB7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_105834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551262.1">
        <property type="nucleotide sequence ID" value="XM_009552967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTB7"/>
    <dbReference type="STRING" id="747525.W4JTB7"/>
    <dbReference type="GeneID" id="20666106"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_105834"/>
    <dbReference type="HOGENOM" id="CLU_046025_2_0_1"/>
    <dbReference type="InParanoid" id="W4JTB7"/>
    <dbReference type="OrthoDB" id="3223377at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="162"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW76340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="332" mass="37164" checksum="22080446109ED0FD" modified="2014-03-19" version="1">MPFLNAEPLDPSSYVFILSGLTLIGTFISLILYGVVLMQTYSYHVTYKDDKAWQKAYVWTLFVVGTVNIGLDMAHIYDHLVNKFGPLTTGIIGSMVQLFLGRRIWILTNSLWVFITIVALAAIECIAAMATSVAMFCTPDILLTSRIQSTVIIWLIATTIDDTLITVILVTFLKRHKTGSPPTDDIIDKIIRLAIQTGLVTALWAVADIVLYITFVRPSPSPVPVTPPQPISDWVLHRRFTSQLRSDYIVFGYPLAELYMISLLSSLNSRKGWTSSVESTRYIGGISRPRTIEFCDRSAVRDVGRPPYLIPFIVPDLFARLRAKSCPATQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTN4</accession>
    <name>W4JTN4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_422180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551669.1">
        <property type="nucleotide sequence ID" value="XM_009553374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTN4"/>
    <dbReference type="GeneID" id="20673784"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_422180"/>
    <dbReference type="eggNOG" id="ENOG502S8UP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052543_2_0_1"/>
    <dbReference type="InParanoid" id="W4JTN4"/>
    <dbReference type="OrthoDB" id="2858653at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42057">
        <property type="entry name" value="F-BOX DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42057:SF2">
        <property type="entry name" value="F-BOX DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00200)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="45982" checksum="309D3924BE53FE7E" modified="2014-03-19" version="1">MNTLPYELLDAIVDEVPNRTDLAQIRTVNKVFCALVTRRFFRHVKVKTALKSASEFGEVLGRDRVAEYKPILDLIVDALASSFTRIHELPRLKTLELSFYATHDTSYGDFLIIQWTILSAILSQSPSPSLTSLTINRLAPLYHPIYDSPSSGGLLRSLTSLSVLTAYHDIYTAEDHTRNSYVKFWNEAIQDHMLGSLSHNLATLRLQGQTFVGHIPGPDLSRVNFPALETLSLQKFLFYEGTGVEEFIVRRRKTLRGLWLADCAIAIENLGEGHFARELKALVLLIVQSDCLDDDGSTTDSFGEDDSLKYPQPNWEDWLSYDPWDGPVWFGDGDLLALRELRRLVRSQAAERFLSLLSRYSLVGFGGVVRAYGTGVERVAERGERDGTHPRENIKHYNQVAWYSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTP0</accession>
    <name>W4JTP0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_412062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551787.1">
        <property type="nucleotide sequence ID" value="XM_009553492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTP0"/>
    <dbReference type="GeneID" id="20672992"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_412062"/>
    <dbReference type="HOGENOM" id="CLU_2346965_0_0_1"/>
    <dbReference type="InParanoid" id="W4JTP0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="97" mass="11073" checksum="3D40EC16BC1FF341" modified="2014-03-19" version="1">MSVPISSNPTDTHRIICRTIDEWLDLYGMSPPKPNRVRAFDKVPPTLQPLADDPHRCLFERQCQGYNDRASQSIDSVAKVIQSHNMHEIQSLEVSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTX6</accession>
    <name>W4JTX6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6589 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_421218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550565.1">
        <property type="nucleotide sequence ID" value="XM_009552270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTX6"/>
    <dbReference type="STRING" id="747525.W4JTX6"/>
    <dbReference type="GeneID" id="20673711"/>
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        <property type="entry name" value="DUF6589"/>
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        <location>
            <begin position="78"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6589" evidence="1">
        <location>
            <begin position="409"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20231"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW77008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="489" mass="55326" checksum="E9CF401AD20022DC" modified="2014-03-19" version="1">MMAWKAHEVLRNVGTDGQPTIVVLDNIQAYKRLWNPSLGREAQMIVGTGATAAQMEDCPPGAFELAPLLENCKQNKWFTLMIKALEKHINWVHIHAVKRFHWVDALIFYVPALAMHRDAFGHMFNDQTCKHQINPKRHTVVSMQGMTAALSNFLGQLGITEETYGRKLLFFTGDGKTFEGINKVKKLLSAQEGDFRSFQFVHAVLEIWHTKWTNLIRIFQCHWGTSHEVSDPSTLGYLAQATLSPIPDYLGTNNLSAFFESLAVANRLPCLTALLDDANILVKQYCTTDAYMCAPHPELVGGAWYSNAPIRPTWGIHGMNSSTTGRDIQLNLDKSVRLLGDLNNHGGALQSESLDTGSLLEESKHESPNSRSDWALVNNILLMRDGIWFLEVCHAVTLGDIGRVWEVLKGKAGKFHELDLTQEHFNKYLEEFAQHKGKEFGDKWYRDVLSIYIHNFMCLSDKMEKAVNLADRSLHHTNKCIDNKLRLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTY9</accession>
    <name>W4JTY9_HETIT</name>
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        <recommendedName>
            <fullName evidence="2">Meiotically up-regulated protein Msb1/Mug8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_156673</name>
    </gene>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009552958.1"/>
    </dbReference>
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    <dbReference type="STRING" id="747525.W4JTY9"/>
    <dbReference type="GeneID" id="20667657"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_156673"/>
    <dbReference type="eggNOG" id="ENOG502RBV5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002468_0_0_1"/>
    <dbReference type="InParanoid" id="W4JTY9"/>
    <dbReference type="OrthoDB" id="3362494at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037508">
        <property type="entry name" value="Msb1/Mug8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012965">
        <property type="entry name" value="Msb1/Mug8_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093:SF1">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08101">
        <property type="entry name" value="Msb1-Mug8_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="125"/>
            <end position="322"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="763"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="849"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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            <end position="1061"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="1143"/>
            <end position="1200"/>
        </location>
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            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
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            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
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            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
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            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
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            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
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            <begin position="926"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="953"/>
            <end position="964"/>
        </location>
    </feature>
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        <location>
            <begin position="989"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1167"/>
            <end position="1177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW76331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1221" mass="133483" checksum="AB10CFC7F7047B11" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4JU02</accession>
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        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_454454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_454454"/>
    <dbReference type="HOGENOM" id="CLU_523799_0_0_1"/>
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    <dbReference type="OrthoDB" id="3253362at2759"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW77042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="50288" checksum="F8D0A4A5081DA052" modified="2014-03-19" version="1">MDGGLFPEIQSEIFLYCARNDADDLLHPSKAPLVLTRVCRSWRAIALQSTPSLWTLLQIPRVDSYNHDSLCRALETWLSLSNRRPLTISVIAPAQPYVDRLLAIIGAHSHRWKDMVLQLPVMPPLDDAPPLLERLALTTYGDRGIESFVPAILSAKRLRHLAVRPDSWHEEFQSLFSSRILEVFSAHCWHRSPSWDMGRFADNARGSHLVALRLSFRELAVKNTDIGTRCILPRLESLNISIEDCDAIAVFIDALELPRLKCLELSAAPLLKKSKRIGPSLLSLLSYCTDTISKICLRSVRMPPAHLQAVLASANNIQSLTLTNTYHASLVLKHLALVFSPTGELTRGQNTNLSYLCVLPQWEDADKCRYYCRQLVKVVESRRRCGRVAKLKGLGICTQTWSEAEEKGLVDPLHRMIWRDEGLRVHEGGRMETGDEWFARMTDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JU43</accession>
    <name>W4JU43_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_326652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009552242.1"/>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_326652"/>
    <dbReference type="HOGENOM" id="CLU_2292061_0_0_1"/>
    <dbReference type="InParanoid" id="W4JU43"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="101" mass="11415" checksum="C0F2DBD41B6C0B2A" modified="2014-03-19" version="1">MSATSYSSSPRVLFRGLPCTLTLRHPPCLTPPGDALRSGYCECGLWMRRLAEPHAEDTMGARCRRPARREHVSVQAILIFLPQTLLQRIHRHSPVARRLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JU87</accession>
    <name>W4JU87_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_429463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550664.1">
        <property type="nucleotide sequence ID" value="XM_009552369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JU87"/>
    <dbReference type="GeneID" id="20674346"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_429463"/>
    <dbReference type="eggNOG" id="ENOG502SUXU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_871714_0_0_1"/>
    <dbReference type="InParanoid" id="W4JU87"/>
    <dbReference type="OrthoDB" id="3231188at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW77118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="319" mass="35905" checksum="EE532A6D69ED3691" modified="2014-03-19" version="1">MTDLSHSDDKDIQAIPVPGKNATLEDYQEALKIAQLQVVGKHQTALQKICTLVGTLQSNQQSHRKGPKTVKKHDEEISMLGHKCSVMVPHPVIEANSPNRYLSEMSTKQGVVADLHDLVPPKLHKMMQKYSPFAQKFRAALSGSCSSIIHHLRGSITKIFPSSKADYFQIDFKGYEDLPEFQAYLKFDATKSSYPTFAPILYPNLKKNDKKLFQSMILVHARFIVSPNIRFEQQGAHSRINYQKDFNRYKEILIKGAQRPNLPSNLMHNDNNEERDEFDASAILAGMDAKDVDNDDDNMGVEISDTTNILSSLGLDNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUR2</accession>
    <name>W4JUR2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_479883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550805.1">
        <property type="nucleotide sequence ID" value="XM_009552510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUR2"/>
    <dbReference type="GeneID" id="20677889"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_479883"/>
    <dbReference type="eggNOG" id="ENOG502QQPD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031812_1_1_1"/>
    <dbReference type="InParanoid" id="W4JUR2"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03887">
        <property type="entry name" value="M20_Acy1L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="2">
        <location>
            <begin position="274"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW77278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="526" mass="56029" checksum="51AAC4AA6BA43FAD" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUS4</accession>
    <name>W4JUS4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Arabinogalactan endo-beta-1,4-galactanase</fullName>
            <ecNumber evidence="3 6">3.2.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_37715</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>The enzyme specifically hydrolyzes (1-&gt;4)-beta-D-galactosidic linkages in type I arabinogalactans.</text>
            <dbReference type="EC" id="3.2.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 53 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.89" evidence="3 6"/>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551149.1">
        <property type="nucleotide sequence ID" value="XM_009552854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUS4"/>
    <dbReference type="STRING" id="747525.W4JUS4"/>
    <dbReference type="GeneID" id="20671867"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_37715"/>
    <dbReference type="eggNOG" id="ENOG502QU6R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011259_0_0_1"/>
    <dbReference type="InParanoid" id="W4JUS4"/>
    <dbReference type="OrthoDB" id="110914at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031218">
        <property type="term" value="F:arabinogalactan endo-1,4-beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011683">
        <property type="entry name" value="Glyco_hydro_53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34983">
        <property type="entry name" value="ARABINOGALACTAN ENDO-BETA-1,4-GALACTANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34983:SF1">
        <property type="entry name" value="ARABINOGALACTAN ENDO-BETA-1,4-GALACTANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07745">
        <property type="entry name" value="Glyco_hydro_53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005150313" description="Arabinogalactan endo-beta-1,4-galactanase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW76651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="341" mass="36371" checksum="24BB2E15F70569B8" modified="2014-03-19" version="1">MICYLLLSCIFFAHSLALTYKGADLSSILLVESQGVKYTDGGPAKPFETILTSHGSNTARIRVWTTGQYDLQYGLKLAKRVKAAGMTLIVDLHYSDTWADPGHQSIPSGWPTTLSGLNTQIYTYTKDVVKQFSDQGTPIDILQVGNEINNGLLWPVAEISVNGINPVSQLLHSAINGAKSVASPKILIHLANGWDWSGLSSFFSGVFIQGALATSDVDIIGVSFYPFYDSGATLAALKSSLTNLANTYGKPIVVAETDWPVSCSGVSLTEPSIPVSVAGQLTWITDIKNVLSGLPKGLGQGIFYWEPGWIGNAALGSACSDNLLVSSSGATRSSINIFKNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4JV58</accession>
    <name>W4JV58_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_455355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551823.1">
        <property type="nucleotide sequence ID" value="XM_009553528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JV58"/>
    <dbReference type="GeneID" id="20676614"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_455355"/>
    <dbReference type="HOGENOM" id="CLU_1678134_0_0_1"/>
    <dbReference type="InParanoid" id="W4JV58"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="157" mass="16234" checksum="4BE743E458B0EDC2" modified="2014-03-19" version="1">MSLSPSSISLPPSAPSSSPVHAHLSPSTSSPRCPQRPILRLYPPPPLVRSTSPTSDPLSRPTCSPVQLALPPGPLDPIARCTALPALLARSHAHWPTGRLARIVHIVSRIAWLDTTAVHHPGTSSASSTFVNTSTSASSSAVATTTTHTTTTTASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4JV66</accession>
    <name>W4JV66_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_173996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550880.1">
        <property type="nucleotide sequence ID" value="XM_009552585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JV66"/>
    <dbReference type="FunCoup" id="W4JV66">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JV66"/>
    <dbReference type="GeneID" id="20668481"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_173996"/>
    <dbReference type="eggNOG" id="KOG2852">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_14_0_1"/>
    <dbReference type="InParanoid" id="W4JV66"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF150">
        <property type="entry name" value="OXIDOREDUCTASE TDA3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW77364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="408" mass="43368" checksum="74844D0DD46A7022" modified="2014-03-19" version="1">MSSKHVVIIGGGIIGSTTAFYLAHHAASTSVTITLLEASKEGVAQGASGKAGGLVAKWAYPKELAQVSFQEHARLAREFDGEARWGWRWTGVGEWEGRGREASDERVKESSGETKTLSKKLGLPAAGGSNKSRRAKGLPTDLAWVDEELTDSYTPLAPSGDTAQVHPYLFTTSMLNLASEKGVRLIKGKVISLESDSGQITGVRYCSSEGAFSEEVNLAADTVILAAGAWSPTLLSSLPITGTRAHSIIIRPSMQADVIAPYVLFTSIALPAGGRNVTPEIYPRPDSTIYVCGPGDTREALPLTVDEVKTDPLACEEIWEWVAETGIIQSNVLGEIEKHQACYLPIVENEGGPIIGNVPNMKGLVVATGHTCWGICNAPGTAKAVSELVLEGKIKCANLRSLDPSLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4JV99</accession>
    <name>W4JV99_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MICOS complex subunit MIC10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_327697</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Mitochondrion inner membrane</location>
            <topology evidence="2 9">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the MICOS complex subunit Mic10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550999.1">
        <property type="nucleotide sequence ID" value="XM_009552704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JV99"/>
    <dbReference type="FunCoup" id="W4JV99">
        <property type="interactions" value="170"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JV99"/>
    <dbReference type="GeneID" id="20671350"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_327697"/>
    <dbReference type="eggNOG" id="KOG4604">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068905_4_0_1"/>
    <dbReference type="InParanoid" id="W4JV99"/>
    <dbReference type="OrthoDB" id="1916310at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007512">
        <property type="entry name" value="Mic10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304:SF0">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04418">
        <property type="entry name" value="DUF543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW77503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="86" mass="9188" checksum="CB1927D64C524915" modified="2014-03-19" version="1">MSANARPNSSEDIVAQKYDRCLADLIVKAGIGFSVGVVASVILFRRRAWPIALTTGFGAGAAYADCDRSFNPARIAGVRVLKEESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVC3</accession>
    <name>W4JVC3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1688-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_446215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550585.1">
        <property type="nucleotide sequence ID" value="XM_009552290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JVC3"/>
    <dbReference type="STRING" id="747525.W4JVC3"/>
    <dbReference type="GeneID" id="20675677"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_446215"/>
    <dbReference type="eggNOG" id="ENOG502QR4F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026445_1_0_1"/>
    <dbReference type="InParanoid" id="W4JVC3"/>
    <dbReference type="OrthoDB" id="2153176at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012469">
        <property type="entry name" value="DUF1688"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687:SF3">
        <property type="entry name" value="PROTEIN URG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07958">
        <property type="entry name" value="DUF1688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="48561" checksum="81CC2980C4A84528" modified="2014-03-19" version="1">MNIANAGLSLEQKIAYLRTLPAIRERCGRVYELAKQGKLQYFDYNSDREDVAADYCIKIIERDFGKDYASIPPHGRWRHLDAGLPRVQPLIEKWNASASPPDIKEVTKRLLDLFLVSVLLDAGAGNAWAYYEAVSEQKFTRSEGLGVASMHMFQEGFFSGDRAQPYRVDAAGLAQITVERTAQAMQVDASNPMVGLEGRASLLKNLSRALKQNPVFFGDGGRPGNILDYLETESILDGKTRRVPLAALWHVLITGLAPIWPSDRTSLGGVPLGDVWPCDALKAAAVEEGDEFVPFHKLTGWTTYSLVEPIEKVLGWKFEGLEDMTGLPEYRNGGLLVDLGILSLKKSVISATFYPSPSSTIPRLPPSHPAIIEWRAMTVIELDRLADLIRRKLTLTVDQLTLAQVLESATWKGGREIAKEKRPETSGPPIDIQSDGTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWF0</accession>
    <name>W4JWF0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_118433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550924.1">
        <property type="nucleotide sequence ID" value="XM_009552629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWF0"/>
    <dbReference type="STRING" id="747525.W4JWF0"/>
    <dbReference type="GeneID" id="20666586"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_118433"/>
    <dbReference type="HOGENOM" id="CLU_1098618_0_0_1"/>
    <dbReference type="InParanoid" id="W4JWF0"/>
    <dbReference type="OrthoDB" id="61113at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW77415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="253" mass="29551" checksum="A1899803CC1DA819" modified="2014-03-19" version="1">MQSLFRMFLEGSLRDGEVWVAGFDNRIEAAALWTEPGKDAIISMHENYQALLSDEMKDWLKFHLIPKYKELYNTSFSAGESTRMQAWHLNLVAVDPQHYRRGLGRALPCIYSHYPVQADRNHQTMTADVPTLHSVYFFQSLGFKYKGVKNFIRHMTGKSRVQLLATTLVEQSVQYFSGQFYQESLSRKTRKLQFWTYCDPRITNWQRIAKRSRVNYNIKNMPVASLQASRFKFEAFLDMSGIVADWHPLNLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWM3</accession>
    <name>W4JWM3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Required for respiratory growth protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_479105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for respiratory activity and maintenance and expression of the mitochondrial genome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRG9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549965.1">
        <property type="nucleotide sequence ID" value="XM_009551670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWM3"/>
    <dbReference type="GeneID" id="20677852"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_479105"/>
    <dbReference type="eggNOG" id="ENOG502S7IA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1510814_0_0_1"/>
    <dbReference type="InParanoid" id="W4JWM3"/>
    <dbReference type="OrthoDB" id="5578174at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010487">
        <property type="entry name" value="NGRN/Rrg9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475:SF3">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06413">
        <property type="entry name" value="Neugrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW77952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="178" mass="20858" checksum="88AA7650633A6696" modified="2014-03-19" version="1">MLEELKEPDEQASNLPHSSNFAPLKPPTPDEWKSHRGTMRSQFPQGWAPPRRLSRDAMEGLRSLHAYDPATFSTPILAQKFHVSPEAVRRILRSKWQPTKDERARMVQREQKTRQEWIKQRRVEERMRDIAAQLEGDQRGEFKTVGAADQRDGSRRDWDRKRSGKVTGINRYDKLSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWR6</accession>
    <name>W4JWR6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_479179</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550008.1">
        <property type="nucleotide sequence ID" value="XM_009551713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWR6"/>
    <dbReference type="FunCoup" id="W4JWR6">
        <property type="interactions" value="260"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JWR6"/>
    <dbReference type="GeneID" id="20677858"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_479179"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_172_3_1"/>
    <dbReference type="InParanoid" id="W4JWR6"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF68">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATG1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="347"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW78002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="417" mass="46272" checksum="71D2D8E755FE3C9F" modified="2014-03-19" version="1" fragment="single">MATNTPPRPPALGSFIDNGSLELISVLGYGGYGIVYRALDTTSGAGQRTYAVKCLFHSQSRSHRQRRLQMQEIALHQLASLHPHVVSLHRVIEEDGCTFIVMDYCPDGDLFAQILHKRRYLGHDGLIKHVFLQILDAVEYCHSLGIYHRDLKPENVLCFNGGLRLAITDFGLATTEKISEEFRTGSVYHMSPECQGGIFAPSGTYSPPFNDVWSLGIILLNLITGRNPWKSASPSDPTFHAYLQEPANFLPSVLPISAEVNEILLRTLDVDWRTRITIAELRFAIKGVNSFYAEDAVFEGSMARCSWEVGIDITGSSTPEDEPAELPKKELKSVWSQESGSQMVFAAHSETDKSWTEEPSSATWGADSALRSRSPSPSPPELSTSYELYDDRRTPSSSSSMYSPALSEPSLSNRYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWS0</accession>
    <name>W4JWS0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_436230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550827.1">
        <property type="nucleotide sequence ID" value="XM_009552532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWS0"/>
    <dbReference type="STRING" id="747525.W4JWS0"/>
    <dbReference type="GeneID" id="20674875"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_436230"/>
    <dbReference type="eggNOG" id="ENOG502S3SW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032490_1_0_1"/>
    <dbReference type="InParanoid" id="W4JWS0"/>
    <dbReference type="OrthoDB" id="94039at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="146"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="448" mass="49410" checksum="156120D33C24DB27" modified="2014-03-19" version="1">MTKSSCLSYPRPESFQTWTPINPRPLLPIQPPPLQGLALPPLPSPTRDAAFGPAYTLTTHLVPSAFPRSSADIPQPQVPAHETKVERKARVARVAKEMLALKERQEAGESLGEGSRAVLWNSLNRYVRNEVGGQERHTRKKHLTLFCAHANGMHKETYEPMLRHLLSQSDASYEIDEIWTFDSVQHGDSGLVNAAQLRGMFDWADNARDILSFFLNYLPDGVSSEPLPTHLERVPSAVADQRRASGFNQRSLVCVGHSYGGCSLVMGAHDSPALFSSLILVDPVLIPEGYDRSAVLPGMVLAAVARRDIWSSREEAHKLLSASPFFGRWDPEVLKAYVEHAITSDGTGNVTLKTSGIQEAVVFLESLVCSEAFALMPKIDERISLKWIMPGPPEEGIAGDAVSRERVWLRPQNASNVRILGAGHLAVQEKPLEVGEASSQLCRRVRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JX07</accession>
    <name>W4JX07_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_327764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550915.1">
        <property type="nucleotide sequence ID" value="XM_009552620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JX07"/>
    <dbReference type="GeneID" id="20671357"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_327764"/>
    <dbReference type="HOGENOM" id="CLU_1175557_0_0_1"/>
    <dbReference type="InParanoid" id="W4JX07"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW77406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="236" mass="27270" checksum="A47BD5B50348F9F5" modified="2014-03-19" version="1">MDVSMIRKMRRQGDIPYRLIPKNPLEFNDDPCFPMDRKQVIPLCNVIESYYDMMGYASGRFRTTVYFGCETVSGIWPRSMRSHRHAEIPHQRNKVITCRKFNSSDGTFSPSFEATVVNRYMNRALLGVDIPYYRAHSSTPRGPEDVQRLIGEMCLVKELVEDPSDPEGDHFLWEWTPAIIESDWAGPFLVRFEKGYRAHLKHGDELVHAIWAAPNTAQARDILRAHDEPMAEPVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXA0</accession>
    <name>W4JXA0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_105372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551007.1">
        <property type="nucleotide sequence ID" value="XM_009552712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXA0"/>
    <dbReference type="GeneID" id="20666061"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_105372"/>
    <dbReference type="eggNOG" id="ENOG502SY6F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1547788_0_0_1"/>
    <dbReference type="InParanoid" id="W4JXA0"/>
    <dbReference type="OrthoDB" id="3010419at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW77511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="173" mass="19680" checksum="20A553031A66B2B8" modified="2014-03-19" version="1">MLNISSLKSLTIGPGHTHSKDVILSLLEGTPNLEILDIYYDAFLEDFYELAPASYPGLRQLHDLTVRHQGVALKHQFAALFKWIQAVVPTPSLEHLELVSDDSRECKYSQTFVEMIRQYPSLKTLTVPSVHLTNSEFKQTVAQCSRLSTLYFTVRGVGGKETKRRKFWREGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXS4</accession>
    <name>W4JXS4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_325058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550307.1">
        <property type="nucleotide sequence ID" value="XM_009552012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXS4"/>
    <dbReference type="STRING" id="747525.W4JXS4"/>
    <dbReference type="GeneID" id="20671107"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_325058"/>
    <dbReference type="HOGENOM" id="CLU_196206_0_0_1"/>
    <dbReference type="InParanoid" id="W4JXS4"/>
    <dbReference type="OrthoDB" id="6511194at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="80" mass="9270" checksum="33355EA0C28DC7E7" modified="2014-03-19" version="1">MCIWAKCSLVCSIENEHCCMARLLSNQADVKNQVSLLEQEITAHSHICMFLPKFHCELNLMEMMSKLLILPFSILFFSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXX5</accession>
    <name>W4JXX5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_411410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550403.1">
        <property type="nucleotide sequence ID" value="XM_009552108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXX5"/>
    <dbReference type="GeneID" id="20672948"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_411410"/>
    <dbReference type="eggNOG" id="KOG0527">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1351770_0_0_1"/>
    <dbReference type="InParanoid" id="W4JXX5"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="78"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="78"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW78432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="203" mass="22657" checksum="7357599708D97C02" modified="2014-03-19" version="1" fragment="single">MSRSDHILAHHPHRTSATAGPNNSDLDDAPRRLDRDSSLSGSDDSSSVPHSPQTQKLSADSPEDVQLTAQTLNADGTPKRPMNAFMIFARRRRPQVSAANQMMRTGEISKILSREWTSMDLSDKQYYLDQAKHLKDNFNSKYPDYVYRRRPNNSRKKRKLDATLNTLLDSGSSADHLDDVGATHGFDYASSVEDDGAVHASTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4JY38</accession>
    <name>W4JY38_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_163994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550020.1">
        <property type="nucleotide sequence ID" value="XM_009551725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JY38"/>
    <dbReference type="GeneID" id="20667883"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_163994"/>
    <dbReference type="HOGENOM" id="CLU_1949090_0_0_1"/>
    <dbReference type="InParanoid" id="W4JY38"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="129" mass="14078" checksum="CCCC9D3A2D5D0F60" modified="2014-03-19" version="1">MPEGSRPSSVPDHHVGNPSYAARARAASSVFWGERLHMYLFPNLGTVTTSSQRFTFPSSLLPCAPEAVVHVLLMVMSVGRVPHLPWRHASAPNPGPSNTPCPLAYYSIPMAPKHMLLRAVQVVVLHAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4JY59</accession>
    <name>W4JY59_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7729 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_325408</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550044.1">
        <property type="nucleotide sequence ID" value="XM_009551749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JY59"/>
    <dbReference type="GeneID" id="20671149"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_325408"/>
    <dbReference type="eggNOG" id="ENOG502S3AD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042319_4_1_1"/>
    <dbReference type="InParanoid" id="W4JY59"/>
    <dbReference type="OrthoDB" id="2564812at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056146">
        <property type="entry name" value="DUF7729"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39460:SF1">
        <property type="entry name" value="C6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39460">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24855">
        <property type="entry name" value="DUF7729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7729" evidence="3">
        <location>
            <begin position="212"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW78040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="456" mass="46627" checksum="90DB322480785451" modified="2014-03-19" version="1">MFTPPDSPLAPPKRSRDTPSPTPSPTPSSRATTPTPPSRLAAPSSTSSSPSPSRSPSPSPSKLRPHVTHTHSTDAPTAHERKQRIARRTRLSMLLVPLVLILITITTHYTAHPRVLDLLSSASPDPHLAWSDLAGWGTHPAHVRRQDAAASEVVSTAAGTISFPSSLSISASSTSASGTASSVAASSSSSGTPVAASGIPTIPSTAPVLPTPFPQPFDSMSTEGFLTVGCMQFVVNMTLDPQFRPCRPFSLLMETSSAFIKAQNNITALNIDVWGTCNTPVDADQCAATMAMYASELPNQCQAEIDNKKTVVLQALTGLQTYALYRDVGCLANNSTGAYCYVEAAAAASPADLYFYGLAWGSALPAGTTPSCSVCTKRVMALFAEGRGGVTGLQATYDAAAEVAAQACGAGYVQLASGVSGAGPRTRAGTAGVGVGAGAVVAIGLGLGLGAGVGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZF7</accession>
    <name>W4JZF7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_117632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549247.1">
        <property type="nucleotide sequence ID" value="XM_009550952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZF7"/>
    <dbReference type="GeneID" id="20666559"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_117632"/>
    <dbReference type="eggNOG" id="ENOG502T2KJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_834287_0_0_1"/>
    <dbReference type="InParanoid" id="W4JZF7"/>
    <dbReference type="OrthoDB" id="2836053at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="40505" checksum="48684C7087255612" modified="2014-03-19" version="1">MMDSLSTRFQHLLIIDPIILQTSQPSWPYLPVELIQRILEKAWTSPLTGEEVTSMLTSLPLVSKTFLAIYNRLAFRDVHVATEDYSDRFQPLLSSRTPEKEAYCEAHPLLSIPSPTTINSLCRSITFHIPGLGGYPGKDPIQLYSENHPMGQALSGTLYQLKRLPWLPSLRHITIEYTNWGYNDIFDQDRLLDLPLRVSTLELRYLFTANIGKRSIRGLSNRYFGRQRWRSGHYSLPGVRELIVSGDCLDIVVDVAHMCPTLKVLEVDELKGISVLAPLPPSVHTLVLRSGRGFILNDDSLQEMQLERALKNKLFGSSEHPRIILESASVDPTVFNYTVNLCQNHDIELIHRSLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W4K003</accession>
    <name>W4K003_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[RNA-polymerase]-subunit kinase</fullName>
            <ecNumber evidence="2">2.7.11.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HETIRDRAFT_36188</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.23" evidence="2"/>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548747.1">
        <property type="nucleotide sequence ID" value="XM_009550452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K003"/>
    <dbReference type="FunCoup" id="W4K003">
        <property type="interactions" value="792"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K003"/>
    <dbReference type="GeneID" id="20671816"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_36188"/>
    <dbReference type="eggNOG" id="KOG0659">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="W4K003"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07841">
        <property type="entry name" value="STKc_CDK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000097">
        <property type="entry name" value="Putative cyclin-dependent kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000498">
        <property type="entry name" value="Serine/threonine-protein kinase KIN28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037770">
        <property type="entry name" value="CDK7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF0">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="15"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="21"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETW79127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="365" mass="41340" checksum="62810DEDA779553B" modified="2014-03-19" version="1">MDAVEKANLARQKRWTKDQKVGEGTYAVVYRGREAATGRKVAIKKIKVGQLKDGLDMSAVREVKYLRELHHQNVIELLDVFSSKANLNLVLEFLDTDLEMIIKNRSLVFLPADIKSWMAMTFRGLEFCHRNFVLHRDLKPNNLLIASDGQLKIADFGLARDFADPGYKMTCQVITRWYRPPELLFGCRYYSTAVDIWSVGCIFAELMLRTPYLPGESDMDQLKTIFRALGTPTEEDWPGHTKLPDYVPVGQFPRAPLRELFTAASADTLNLLSKCLIYEPRKRISAKDALSHPYFFALPYPSHPSKLPRSVPFGSQKALEEVDGNVDFTGDGPKVKAAAPGRLKRKLSKDDIGRNIARKLDFSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4K015</accession>
    <name>W4K015_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Metallo peptidase M20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_64447</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548817.1">
        <property type="nucleotide sequence ID" value="XM_009550522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K015"/>
    <dbReference type="FunCoup" id="W4K015">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K015"/>
    <dbReference type="MEROPS" id="M20.002"/>
    <dbReference type="GeneID" id="20678680"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_64447"/>
    <dbReference type="eggNOG" id="KOG2275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_11_0_1"/>
    <dbReference type="InParanoid" id="W4K015"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05674">
        <property type="entry name" value="M20_yscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000027">
        <property type="entry name" value="N-fatty-acyl-amino acid synthase/hydrolase PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017141">
        <property type="entry name" value="Pept_M20_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037217">
        <property type="entry name" value="Carboxypeptidase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="8">
        <location>
            <begin position="233"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW79137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="539" mass="58657" checksum="0210E3AFF1296321" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1J0</accession>
    <name>W4K1J0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_49662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548755.1">
        <property type="nucleotide sequence ID" value="XM_009550460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1J0"/>
    <dbReference type="FunCoup" id="W4K1J0">
        <property type="interactions" value="610"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K1J0"/>
    <dbReference type="GeneID" id="20678119"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_49662"/>
    <dbReference type="eggNOG" id="KOG0797">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006974_0_1_1"/>
    <dbReference type="InParanoid" id="W4K1J0"/>
    <dbReference type="OrthoDB" id="5572108at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10206">
        <property type="entry name" value="ASKHA_NBD_Arp8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="423"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="462"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW79210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="638" mass="70953" checksum="F19B831F96BBAB7E" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4K410</accession>
    <name>W4K410_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BAG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_476210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547285.1">
        <property type="nucleotide sequence ID" value="XM_009548990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K410"/>
    <dbReference type="FunCoup" id="W4K410">
        <property type="interactions" value="182"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K410"/>
    <dbReference type="GeneID" id="20677665"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_476210"/>
    <dbReference type="eggNOG" id="ENOG502SGZ8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082772_0_0_1"/>
    <dbReference type="InParanoid" id="W4K410"/>
    <dbReference type="OrthoDB" id="417450at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039773">
        <property type="entry name" value="BAG_chaperone_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12329:SF16">
        <property type="entry name" value="BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12329">
        <property type="entry name" value="BCL2-ASSOCIATED ATHANOGENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00264">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="BAG" evidence="4">
        <location>
            <begin position="147"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW80552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="21854" checksum="889526FEAB82D754" modified="2014-03-19" version="1">MSILVKWGRERLHFPLPALDTKLGALRNTLAEYTHLPSSSFKLIHAGAVMKDDNAPLSAYGIHANSTILLLDSTPQAAAASSPNASTASSNTKKVPAHREPKTEASTISQIRAELDAVQQTLEPGVDGFLNNIGAPERSDPAALEAEHRRLGELLLQALLRLDAIGFEGGWEDARRERKGAVKIVQGLLDRLDVGWRARARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4K470</accession>
    <name>W4K470_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_154839</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547277.1">
        <property type="nucleotide sequence ID" value="XM_009548982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K470"/>
    <dbReference type="STRING" id="747525.W4K470"/>
    <dbReference type="GeneID" id="20667526"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_154839"/>
    <dbReference type="eggNOG" id="KOG1305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009020_4_1_1"/>
    <dbReference type="InParanoid" id="W4K470"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="29"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW80544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="438" mass="47335" checksum="210957D4396D9886" modified="2014-03-19" version="1">MGEANGNGSGMTAGDMDLEELAAKQHSGGGMFNSITNMANSILGAGIIGLPYAISKAGFWTGMFLLIVLCAVTDWTIRLIVTNAKMSGANSYIGIMNHCFGSSGRAAVSFFQFAFAFGGMCAFGVIIGDSIPHVIRSIFPTLPTIPVLSIFANRQFVIALCTLGVSYPLSLYRDIHKLSISSAFALVGMLIIVFSVTFEGPHVPPELKGDPAKRFSLIDSGIFQAIGVISFAFVCHHNTLLIYGSLRTPTLDRFAKVTHVSTAISLVACSIIAVSGYMVFTDKTQGNILNNFSPTDSLINVARFCFGLNMFTTLPLELFVCREVIEQYFFSHETFSIQRHVFFTTTILLASMFIALVTCDLGVMLEIIGGVSATALAFIFPAACYLKLAGAHAHRPWYTRERLPAYVCVTFGVTVMLLSLFLALGKVWTPEGNATICM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5K5</accession>
    <name>W4K5K5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_320049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547724.1">
        <property type="nucleotide sequence ID" value="XM_009549429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5K5"/>
    <dbReference type="STRING" id="747525.W4K5K5"/>
    <dbReference type="GeneID" id="20670638"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_320049"/>
    <dbReference type="eggNOG" id="KOG0700">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020130_0_0_1"/>
    <dbReference type="InParanoid" id="W4K5K5"/>
    <dbReference type="OrthoDB" id="420076at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="37"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="388" mass="43356" checksum="6B68652FC62A399B" modified="2014-03-19" version="1">MLSETHLSNELRRLANPCSREGVDGITFQPCPIFEFRSQDRSRIEHWPMPGGTWVFTAIFDGHAGHSTVDHTAQTIPVMVKNSLDAYLRASPRTPPSPDRISSILSDAIVRFDHSITTEFLSLFPGGPAALARMSDGQIRHIIDDRATGGRNTTSAIRCLQGSTALITLTDPAKINLWVANLGDCQAVLGSRNAQGQWHASFATTLHDGENLHEIHRIRSEHPGERESTLDNRVIGFLGPTRSVGDTWLKIPAIYSQRVLLGFRQEWTVERPEPFISRITTPPYVSSTPDVYHLPLPRGAPGRPRDLFLLMCSDGLGDLYDDRSRADIINRWVRTVGRSLDSRDQSNLSLILLRDALGGADTRLVSQYLTVEMDEKWMDDVTVIVQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4K673</accession>
    <name>W4K673_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_61667</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546963.1">
        <property type="nucleotide sequence ID" value="XM_009548668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K673"/>
    <dbReference type="GeneID" id="20678565"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_61667"/>
    <dbReference type="eggNOG" id="KOG2262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004965_3_0_1"/>
    <dbReference type="InParanoid" id="W4K673"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="624"/>
            <end position="645"/>
        </location>
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    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="385"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="704"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="68"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="588"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="852"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="589"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="884"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW80746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="897" mass="100871" checksum="2B5CF91DD546CCDD" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6T0</accession>
    <name>W4K6T0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_321333</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547730.1">
        <property type="nucleotide sequence ID" value="XM_009549435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6T0"/>
    <dbReference type="FunCoup" id="W4K6T0">
        <property type="interactions" value="409"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K6T0"/>
    <dbReference type="GeneID" id="20670739"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_321333"/>
    <dbReference type="eggNOG" id="KOG2227">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025750_0_0_1"/>
    <dbReference type="InParanoid" id="W4K6T0"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049945">
        <property type="entry name" value="AAA_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="192"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="492"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="575"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW81050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="680" mass="72816" checksum="D4FF2C0EC7A0DDE0" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6T1</accession>
    <name>W4K6T1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 10">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1 10">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 10">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_319562</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1 10"/>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547475.1">
        <property type="nucleotide sequence ID" value="XM_009549180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6T1"/>
    <dbReference type="FunCoup" id="W4K6T1">
        <property type="interactions" value="455"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K6T1"/>
    <dbReference type="GeneID" id="20670608"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_319562"/>
    <dbReference type="eggNOG" id="KOG2623">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024003_0_0_1"/>
    <dbReference type="InParanoid" id="W4K6T1"/>
    <dbReference type="OrthoDB" id="337870at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000001">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF0">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="TYROSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW80766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="477" mass="52752" checksum="47EB38D1A426CD5A" modified="2014-03-19" version="1">MLHRLHPLKRTSRLLLQRHPPNLRRCFHSETVLSELEDRGFISAVTRREQLIGTLQASRQTVYSGIDPTARSLHVGHLLPMMCLVHFQLQGHHIIPLIGGATALIGDPSGRSAERPHLERAAVEEDMQKLTANVQTFFDRALAYAAKKRPSSQESYSTARVMNNIEWLGELGLLEFLRSTGIYARVNTMIARDSVQSRLKSQQGISFAEFSYQLLQAYDFFSLNKRAGCTIQIGGSDQWGNIIAGIELINRTTNSSTSGTSEGDRGFGITTPLLTTATGEKFGKSSGNAVWLDESFTSVFDFYQASHNFFMRTLDDDVGRYLRLFTLLPLSTIDDIVSKHQKHPQQRIAQKILADEVTELVHTVQGVKRAQAATKVLFETDLTDILANDVLHAFRGDTRLHFVNSNEIFGVPVAHLAVRYKLAPSNGAARALVSSGGLYLNGMAIVSGQVLSSRDLIDGNLVILRAGKSKHAIMSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6Z4</accession>
    <name>W4K6Z4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ZIP-like zinc transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_125108</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546243.1">
        <property type="nucleotide sequence ID" value="XM_009547948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6Z4"/>
    <dbReference type="STRING" id="747525.W4K6Z4"/>
    <dbReference type="GeneID" id="20666896"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_125108"/>
    <dbReference type="eggNOG" id="KOG3907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028824_2_0_1"/>
    <dbReference type="InParanoid" id="W4K6Z4"/>
    <dbReference type="OrthoDB" id="19859at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW81612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="329" mass="34489" checksum="77AD98018684042D" modified="2014-03-19" version="1">MQISLLAMSGLLALTSFGVGMLPLSFSYSRKHLSRLSSLGTGLLLGTALGVIIPEYVEGISIVLAESSSQLPTGTIALSLLAGFSLMLVVEQLGSSHVHEAPSDQSLKPRHVVDDVSFDVELGELENEQGIPSRSRDVSPRRGTVESDTKQPAYPLTIGLVIHGLADGLALGVSAVSSGDSSVSSDLSFLVFLALAIHKAPTALAYSTTLLSTSLPRVECKKHLFVFSCSTPVGAVVAYSAFAFLGISQAHNVGIALLISGGSFLYVATVLQPVSHHALPGVSAEEEGKKSRIIFILLGMFIPYFIGSVLEHGHDHASTSSPALESPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7S9</accession>
    <name>W4K7S9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_156203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546059.1">
        <property type="nucleotide sequence ID" value="XM_009547764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7S9"/>
    <dbReference type="GeneID" id="20667624"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_156203"/>
    <dbReference type="eggNOG" id="ENOG502SRUT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089679_0_0_1"/>
    <dbReference type="InParanoid" id="W4K7S9"/>
    <dbReference type="OrthoDB" id="2887913at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="191" mass="21748" checksum="90C5CDEDF0BA50F5" modified="2014-03-19" version="1">MANNTELWLVYHQTSRTSKPATAQLIDLELQHPLTDLEDVLEHIFQQGFVDAKYRSMTWWEQHDGVSVKATHGVQELLKLGVGRSPETALRLVIADRPPALWFTYVFLRTPRAQAATQRVKLDAPNLKCERLAHITNHIFAKGYLPANYRSLVHWQGACGKQVDENAKVEDLLSWGEGVSEDKSLRLIIDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8N0</accession>
    <name>W4K8N0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 15">Aurora kinase</fullName>
            <ecNumber evidence="1 15">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HETIRDRAFT_318059</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1 15"/>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546671.1">
        <property type="nucleotide sequence ID" value="XM_009548376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8N0"/>
    <dbReference type="FunCoup" id="W4K8N0">
        <property type="interactions" value="441"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K8N0"/>
    <dbReference type="GeneID" id="20670469"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_318059"/>
    <dbReference type="eggNOG" id="KOG0580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="InParanoid" id="W4K8N0"/>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045143">
        <property type="term" value="P:homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044779">
        <property type="term" value="P:meiotic spindle checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902115">
        <property type="term" value="P:regulation of organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072479">
        <property type="term" value="P:response to mitotic cell cycle spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="44"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 13">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="123"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="172"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="12">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETW82109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="310" mass="35950" checksum="7E6D83703D79CCF0" modified="2014-03-19" version="1">MGRQRSNLPSIRASLGQCASTTPWPYAHVYYRARPTREWHLYDFDIGRPLGKGKFGRVYMIRTKCEPRYILALKCLYKSEIIQSKVEKQIRREIEIQQNLRHPHVLRLYGYFHDEKRIFLMLEFAGKGELYKQLTKYGSFSERRSAVYIDQMADALSYLHSKHVIHRDIKPENLLLGINGELKIGDFGWSVHAPGNRRTTLCGTLDYLPPEMVEGKVHSEKVDYWALGVLTYEFICGAPPFEDLRGYGATYKRIASVDLHIPSKVSGEARDLIMSLLQYDPDKRIPLSDVRKHPWIVRYRTKAPSEGKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8S2</accession>
    <name>W4K8S2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_451747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546705.1">
        <property type="nucleotide sequence ID" value="XM_009548410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8S2"/>
    <dbReference type="GeneID" id="20676191"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_451747"/>
    <dbReference type="HOGENOM" id="CLU_1532758_0_0_1"/>
    <dbReference type="InParanoid" id="W4K8S2"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="175" mass="18763" checksum="471F5883EE03D81A" modified="2014-03-19" version="1">MGRGRRGEENEVRGEDRGWEGCKEEEGLDRDAPTTSADPSLASTHPSATNPAARRTKRKRTSPTRIAGTEHEEALDAGACQPTANPRPALAIRIPEFLSPTSAPLSRHPLVPTARSGTNQVSTSPPRHLPPPPASSPSRKSNTAVESLDRSTAQIAPLTIVRPQKRTAHTLAYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9G7</accession>
    <name>W4K9G7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="14">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HETIRDRAFT_384116</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14"/>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546335.1">
        <property type="nucleotide sequence ID" value="XM_009548040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9G7"/>
    <dbReference type="FunCoup" id="W4K9G7">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K9G7"/>
    <dbReference type="GeneID" id="20672185"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_384116"/>
    <dbReference type="eggNOG" id="KOG2448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014271_4_2_1"/>
    <dbReference type="InParanoid" id="W4K9G7"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002068">
        <property type="entry name" value="PRK00911.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF5">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="17">
        <location>
            <begin position="68"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="18">
        <location>
            <begin position="405"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ETW81721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="600" mass="63866" checksum="278EE33ED3038B92" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAB8</accession>
    <name>W4KAB8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Metallo peptidase M20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_154741</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546610.1">
        <property type="nucleotide sequence ID" value="XM_009548315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAB8"/>
    <dbReference type="STRING" id="747525.W4KAB8"/>
    <dbReference type="GeneID" id="20667519"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_154741"/>
    <dbReference type="eggNOG" id="KOG2276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008535_1_0_1"/>
    <dbReference type="InParanoid" id="W4KAB8"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017149">
        <property type="entry name" value="GSH_degradosome_Dug2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF8">
        <property type="entry name" value="DI- AND TRIPEPTIDASE DUG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037237">
        <property type="entry name" value="Peptidase_WD_repeats_DUG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="8">
        <location>
            <begin position="519"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW82031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="781" mass="84695" checksum="400EC309EA5D654F" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAJ3</accession>
    <name>W4KAJ3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 12">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">hat1</name>
        <name evidence="15" type="ORF">HETIRDRAFT_54722</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 12"/>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544654.1">
        <property type="nucleotide sequence ID" value="XM_009546359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAJ3"/>
    <dbReference type="STRING" id="747525.W4KAJ3"/>
    <dbReference type="GeneID" id="20678316"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_54722"/>
    <dbReference type="eggNOG" id="KOG2747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011815_0_3_1"/>
    <dbReference type="InParanoid" id="W4KAJ3"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990467">
        <property type="term" value="C:NuA3a histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="14">
        <location>
            <begin position="21"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETW82837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="248" mass="28924" checksum="DAD22FD8B014D14F" modified="2014-03-19" version="1">MTPARSTSPSPSTPGPLLSKPPSLRIRTIRFGLFDIQTWFDAPFPEEYANIPEGRLWICEFCLKYMKSRFGAARHRMKCKSRHPPGDEIYRDGTVSIFEVDGRRNKIYCQNLCLLSKMFLDHKSLFYDVEPFLFYVMTEVDEFGCHFIGYFSKEKRCPKNYNLSCIMTLPVRQRQGWGNLLIDFSYLLSKKERRCGTPEKPLSGLGALGYKNYWKLAVFRYLDSAPDRVRLEGMLYARESRIHSAYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBE0</accession>
    <name>W4KBE0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ca3427-like PBP 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_316275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein SsuA/TauA family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545444.1">
        <property type="nucleotide sequence ID" value="XM_009547149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBE0"/>
    <dbReference type="GeneID" id="20670312"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_316275"/>
    <dbReference type="eggNOG" id="ENOG502QRHZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061316_1_0_1"/>
    <dbReference type="InParanoid" id="W4KBE0"/>
    <dbReference type="OrthoDB" id="1363at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd13637">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054364">
        <property type="entry name" value="Ca3427-like_PBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024">
        <property type="entry name" value="ALIPHATIC SULFONATES-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024:SF47">
        <property type="entry name" value="TAURINE-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22384">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ca3427-like PBP 2" evidence="4">
        <location>
            <begin position="83"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW83162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="296" mass="31734" checksum="9D44DABBA238F6A6" modified="2014-03-19" version="1">MPLRVGYVREHFSSPLLQYAEVDQGKTFTLVECPSGTGQLIARLTNDEIDVAIALTDPLISGIAKGSKAYKLIGSYVNTPLNWAVITGKDSKYKSIADLKGTPLGISRPGSGSQTMASVMALQQGWDTSALEFKVNNDIHGLIASVNDGSTSAFMWEWFTTKPFADAGAVRFIGSVPTPWPSWLIAAHPSHTRAPPDALRTFLSALSAHVRAFDSAEARAGADVAFITDKFGYPEEDVKAWLETVAYPADCAEIPRNVLTDTLKVLEAAGVVQSPTGGQFDLQDFINGQIVALSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBL4</accession>
    <name>W4KBL4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_383269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545465.1">
        <property type="nucleotide sequence ID" value="XM_009547170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBL4"/>
    <dbReference type="STRING" id="747525.W4KBL4"/>
    <dbReference type="GeneID" id="20672151"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_383269"/>
    <dbReference type="eggNOG" id="ENOG502SQDH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016736_0_0_1"/>
    <dbReference type="InParanoid" id="W4KBL4"/>
    <dbReference type="OrthoDB" id="5584477at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="312"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="597"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW83183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="822" mass="92152" checksum="9573C744EF0820D4" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBS9</accession>
    <name>W4KBS9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Diphosphomevalonate decarboxylase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_247911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545575.1">
        <property type="nucleotide sequence ID" value="XM_009547280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBS9"/>
    <dbReference type="STRING" id="747525.W4KBS9"/>
    <dbReference type="GeneID" id="20669209"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_247911"/>
    <dbReference type="eggNOG" id="KOG2833">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040369_3_0_1"/>
    <dbReference type="InParanoid" id="W4KBS9"/>
    <dbReference type="OrthoDB" id="10253702at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977:SF3">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="77" mass="8554" checksum="B2CD591223C268AC" modified="2014-03-19" version="1" fragment="single">TVSAPVNIACIKCGRDTKPVLPINSSLSVPLDQDHLRSTTTSRADRSFEKDRLWLNGTEEEIRADGRLAICMARERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBT6</accession>
    <name>W4KBT6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_383395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545101.1">
        <property type="nucleotide sequence ID" value="XM_009546806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCJ9"/>
    <dbReference type="GeneID" id="20667272"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_148438"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="InParanoid" id="W4KCJ9"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF35">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="14"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW82776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="513" mass="56221" checksum="728C5EF2E15DF86E" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4KD37</accession>
    <name>W4KD37_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_18789</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543150.1">
        <property type="nucleotide sequence ID" value="XM_009544855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KD37"/>
    <dbReference type="STRING" id="747525.W4KD37"/>
    <dbReference type="GeneID" id="20668632"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_18789"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002678_42_25_1"/>
    <dbReference type="InParanoid" id="W4KD37"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060258">
        <property type="term" value="P:negative regulation of filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001382">
        <property type="entry name" value="Transcriptional repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW83767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="51" mass="5829" checksum="2FCEC96020162CC8" modified="2014-03-19" version="1" fragment="single">KKKHVCATCHKAFTTSGHLSRHARVHTGERNHKCPFPGCETRCSRQDNLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDL4</accession>
    <name>W4KDL4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyrimidine 5-nucleotidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_449497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059493_0_0_1"/>
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    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
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        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010237">
        <property type="entry name" value="Pyr-5-nucltdase"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Pyr-5-nucltdase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438:SF1">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW83883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="30172" checksum="24C7FD991FAD2C40" modified="2014-03-19" version="1">MTADQTQGSADSTRLQSRQLTPTDDRLIVFFDIDNTLYSASSKISEAMGTRIHAYFLTLGLSDEEASDLHHKYYSQYGLALRGLTRHHNVDPLDFDQKCDGSLPLEEMIKPDPALRQLFLDIDRSKVRVWALTNAYRTHAQRVLRILHLEDLIDGLIFCDYAEPNFVCKPEPEYYHQALKKANVRDPARCLFIDDSLTNVKAAARLGWGRCVHFCETGLEAMEGGRMKRIGGGDLQSAPDPALEDRIEAVSELRQLRDVWADIFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDZ8</accession>
    <name>W4KDZ8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_381266</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543698.1">
        <property type="nucleotide sequence ID" value="XM_009545403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDZ8"/>
    <dbReference type="FunCoup" id="W4KDZ8">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KDZ8"/>
    <dbReference type="GeneID" id="20672061"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_381266"/>
    <dbReference type="eggNOG" id="KOG0226">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_29_2_1"/>
    <dbReference type="InParanoid" id="W4KDZ8"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12383">
        <property type="entry name" value="RRM_RBM42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034215">
        <property type="entry name" value="RBM42_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF11">
        <property type="entry name" value="RNA-BINDING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="114"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW83974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="219" mass="24708" checksum="8276FDA5238F0E08" modified="2014-03-19" version="1">MDPYSSQNYYQHYQQGMPSTSSDVNPYHQPYQGPMYTNPAASSSHSAPVPANAYEYDVGILAQQSVYVPGAMIDKRGGAGGKLAKGGKRVTVLRKGGGKVWEDQTLLEWSPSWFRLFVGDLSNDVSDDVLANAFNKYTSFQKARVIRDRLSQKAKYGFVAFSDPEDFLKAWKEMDGKYVGNRPIKLKKAEQTSVRPVEIGHRKARQLEKDLKMNRKKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4KE06</accession>
    <name>W4KE06_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_407999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543330.1">
        <property type="nucleotide sequence ID" value="XM_009545035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KE06"/>
    <dbReference type="GeneID" id="20672650"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_407999"/>
    <dbReference type="HOGENOM" id="CLU_2441125_0_0_1"/>
    <dbReference type="InParanoid" id="W4KE06"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW83550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="90" mass="9488" checksum="F463679C645F742E" modified="2014-03-19" version="1">MSSSRSSTYSGFGDCGRYPKLVSSSLSRIDRGGGSPKMLSSKPFSAGVYKTVSRRGCGIFVTDSVSGGCAIEIKLDRELGACHCVWDPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4KE40</accession>
    <name>W4KE40_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_433007</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG29 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543739.1">
        <property type="nucleotide sequence ID" value="XM_009545444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KE40"/>
    <dbReference type="STRING" id="747525.W4KE40"/>
    <dbReference type="GeneID" id="20674645"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_433007"/>
    <dbReference type="eggNOG" id="ENOG502SHP8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034749_0_0_1"/>
    <dbReference type="InParanoid" id="W4KE40"/>
    <dbReference type="OrthoDB" id="21072at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039113">
        <property type="entry name" value="ATG29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040666">
        <property type="entry name" value="Atg29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039362">
        <property type="entry name" value="ATG29_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40012">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40012:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18388">
        <property type="entry name" value="ATG29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Atg29 N-terminal" evidence="8">
        <location>
            <begin position="7"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="91"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="170"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="226"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW84019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="389" mass="42071" checksum="95D788EE283657E3" modified="2014-03-19" version="1">MQAPIVRVIVRIPSNRPEVSSDGPPPVDWNAEKENYLWDVIARSRAMDSGIPDWKSLATRLNVPLPYLLYRAQTRYEQDLRGLQDITGALSPSTTHVSPKSGDDILSPVDKPSNIRRESGRIPNISKLSSSVRLTTPLGVRARLNSLTSNSPARANKTSSSSILTLQGHRRDFSALRPASPLSSGSDSDEAAEKAEEAERQLGEQEELDKKLKALEQMINDESLGLVSSPNLKRKDKESDRGRMGTPFLPKLDGLDRNQMGRSDRSQSISSASSAHGSIPSMPSPPSEPHSLVNRHFSPSEKSTNSTSLSPTGKGPSHIRHTLLANKHKTSEKGSNHGSSASSFSDLSDASLSASGSAMESAFMSNIRGGNSRLSHYGRSYLSGRSGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEI8</accession>
    <name>W4KEI8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_170641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543858.1">
        <property type="nucleotide sequence ID" value="XM_009545563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEI8"/>
    <dbReference type="GeneID" id="20668300"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_170641"/>
    <dbReference type="HOGENOM" id="CLU_2740322_0_0_1"/>
    <dbReference type="InParanoid" id="W4KEI8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW84154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="71" mass="7961" checksum="72CA373BBB6CF564" modified="2014-03-19" version="1">MSIAALQYRTQPVPPRAATFAILLQPLTLSLDVQRIRHSTLVMECSKSRISMEVYFSRISLLARGLSISLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4KF15</accession>
    <name>W4KF15_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Photolyase/cryptochrome alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_62555</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="6">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543263.1">
        <property type="nucleotide sequence ID" value="XM_009544968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KF15"/>
    <dbReference type="STRING" id="747525.W4KF15"/>
    <dbReference type="GeneID" id="20678605"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_62555"/>
    <dbReference type="eggNOG" id="KOG0133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010348_2_1_1"/>
    <dbReference type="InParanoid" id="W4KF15"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.579.10:FF:000003">
        <property type="entry name" value="Deoxyribodipyrimidine photo-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF18">
        <property type="entry name" value="SI:CH1073-390K14.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="8">
        <location>
            <begin position="62"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="326"/>
            <end position="330"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="370"/>
            <end position="377"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="468"/>
            <end position="470"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW83900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="563" mass="64411" checksum="9635DD74DA578AC7" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFB9</accession>
    <name>W4KFB9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">UMP pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_450000</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544209.1">
        <property type="nucleotide sequence ID" value="XM_009545914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFB9"/>
    <dbReference type="FunCoup" id="W4KFB9">
        <property type="interactions" value="92"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KFB9"/>
    <dbReference type="GeneID" id="20675998"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_450000"/>
    <dbReference type="eggNOG" id="KOG4203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067096_2_2_1"/>
    <dbReference type="InParanoid" id="W4KFB9"/>
    <dbReference type="OrthoDB" id="10257085at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000003">
        <property type="entry name" value="Uracil phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF4">
        <property type="entry name" value="URACIL PHOSPHORIBOSYLTRANSFERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="9"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW84552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="215" mass="23353" checksum="59B2A016699828AB" modified="2014-03-19" version="1">MSGVKVNILSHPLVNARLSKLRQTSTTSKEFREGIHDVSLMLGYEASKDLQEETFEGQTPISTFTGSKVKPRIGFTPILRAGLGMTEALLTLFPEAPVYHLGLYREKISLQPVEYYSKLPASPSIDKCFLLDPLIATGGTAVAALHMISDWGVPISDVKLLCVLASQDGLKHVQSEFPGLEIWVAAVDPELTAQGLISPGLGDTGDRLYNTTRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFQ8</accession>
    <name>W4KFQ8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_425938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544325.1">
        <property type="nucleotide sequence ID" value="XM_009546030.1"/>
    </dbReference>
    <dbReference type="GeneID" id="20674055"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_425938"/>
    <dbReference type="HOGENOM" id="CLU_260595_0_0_1"/>
    <dbReference type="InParanoid" id="W4KFQ8"/>
    <dbReference type="OrthoDB" id="2884925at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="781"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1312" mass="146099" checksum="67F6C777EB37AC67" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFU9</accession>
    <name>W4KFU9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lignin medium expressed protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lep10</name>
        <name evidence="1" type="ORF">HETIRDRAFT_171217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544355.1">
        <property type="nucleotide sequence ID" value="XM_009546060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFU9"/>
    <dbReference type="GeneID" id="20668322"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_171217"/>
    <dbReference type="HOGENOM" id="CLU_2558550_0_0_1"/>
    <dbReference type="InParanoid" id="W4KFU9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW84718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="92" mass="9778" checksum="203DC3249D1B08A6" modified="2014-03-19" version="1">MTGIRYKYAIWWLSSPSLRAACAALHTGGPARASVGSRCKTLSACRVRSGPTVPRLGKAGWYWSRCLRGRVTAPGGPTLVDGRAMESRGSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFW9</accession>
    <name>W4KFW9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_123667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543678.1">
        <property type="nucleotide sequence ID" value="XM_009545383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFW9"/>
    <dbReference type="STRING" id="747525.W4KFW9"/>
    <dbReference type="GeneID" id="20666835"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_123667"/>
    <dbReference type="eggNOG" id="KOG2508">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016785_6_0_1"/>
    <dbReference type="InParanoid" id="W4KFW9"/>
    <dbReference type="OrthoDB" id="424465at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF99">
        <property type="entry name" value="BIFUNCTIONAL PEPTIDASE AND (3S)-LYSYL HYDROXYLASE JMJD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="104"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="312" mass="35237" checksum="09A7BB091ECD18C2" modified="2014-03-19" version="1">MNGVHHDILEAPPSALEFSRLWHISRPVVIRGKAMWSNRYLLEHMGDKSFTVAVTPNGYADAVTLGPDGSLYFVEPYIEQRTMSSFLCELESTNATEACYLQSQNGNLYSSTFFHPDMQDSPTEFESLRADVPCELDWCSQAFDRHPDAVNLWIGNSKSITSIHNDPYENIYHVVRGCKTFLLLPPTEGWCLRERLYPHATYIRPSEGSPLILTPSPSSTPMVRWSSITHPERPGALPASAHPITISLQEGETLYLPAGWWHHVRQSDEITVALNWWYDVEGRGATWVWLNLLRGIGNVPLGNGDEEDQQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4KH56</accession>
    <name>W4KH56_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_123961</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544049.1">
        <property type="nucleotide sequence ID" value="XM_009545754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KH56"/>
    <dbReference type="FunCoup" id="W4KH56">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="GeneID" id="20666852"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_123961"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="InParanoid" id="W4KH56"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF40">
        <property type="entry name" value="THIAMINE PATHWAY TRANSPORTER THI73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW84371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="505" mass="56266" checksum="EA621CD986CF2410" modified="2014-03-19" version="1">MQPFVSLEKHSASTEVVKNASKSVVSVTDGDEALRLVGKEREAQFSEEYNLQLRGKLDRWIPPLCAAVYFTQFLDKTSLNYASIMEFPIGGQDYNLVSMAFYLGFLVWEFPTVYISQKLRLAKYLGVNIVLWGIVLMLHATTSSFGAFFALRFLLGMFESCVAPILILIISMFYKKDEQATRISWFYVMNGLTSIFGGFVAYGISFYDGHRLAPWKIIYIVLGGLAIGVGICVLLWMPDSPVHAQNLTREERIAALERVRDDQGGTENKTFKLEQVKETLLDVRTWLIVLTTMLTSIPNGGLSNFSNQIIRSFGYTSKQTLILGTPGGAIAAVTTLLCAWYSDKKNERMLPIVFALVPTIAGAAMLIGLNDSGKKGALLFGTYLISTFGSALSTVYAYNASNTSGHTKKVTINALTMFTFSLGNIIGTEIFLPKDAPAYIPGKIAIMVLLTVQLGVCFLLRFINVHLNSKKRKALEDEILRHGWSDAEVQKERERHAFMDFTDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHU5</accession>
    <name>W4KHU5_HETIT</name>
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        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_121112</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544506.1">
        <property type="nucleotide sequence ID" value="XM_009546211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHU5"/>
    <dbReference type="GeneID" id="20666732"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_121112"/>
    <dbReference type="HOGENOM" id="CLU_378571_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHU5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="403"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW84880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="732" mass="80468" checksum="CF6C3E847C4C29CE" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIG0</accession>
    <name>W4KIG0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chromatin assembly factor 1 subunit A dimerization domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_457354</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542349.1">
        <property type="nucleotide sequence ID" value="XM_009544054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIG0"/>
    <dbReference type="STRING" id="747525.W4KIG0"/>
    <dbReference type="GeneID" id="20676820"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_457354"/>
    <dbReference type="eggNOG" id="ENOG502RY5G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012467_0_0_1"/>
    <dbReference type="InParanoid" id="W4KIG0"/>
    <dbReference type="OrthoDB" id="440676at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022043">
        <property type="entry name" value="CAF1A_DD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272:SF0">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A CAF-1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12253">
        <property type="entry name" value="CAF1A_dimeriz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromatin assembly factor 1 subunit A dimerization" evidence="6">
        <location>
            <begin position="475"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="216"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="518"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="270"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="309"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="518"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="587"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW85494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="792" mass="87797" checksum="5913F1EEB330949E" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIN2</accession>
    <name>W4KIN2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-splicing factor SYF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pre-mRNA-splicing factor syf1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HETIRDRAFT_150121</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle progression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542539.1">
        <property type="nucleotide sequence ID" value="XM_009544244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIN2"/>
    <dbReference type="FunCoup" id="W4KIN2">
        <property type="interactions" value="749"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KIN2"/>
    <dbReference type="GeneID" id="20667351"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_150121"/>
    <dbReference type="eggNOG" id="KOG2047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007736_1_0_1"/>
    <dbReference type="InParanoid" id="W4KIN2"/>
    <dbReference type="OrthoDB" id="10067343at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000023">
        <property type="entry name" value="Pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000137">
        <property type="entry name" value="Pre-mRNA-splicing factor syf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000038">
        <property type="entry name" value="Putative pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056350">
        <property type="entry name" value="HAT_Syf1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23220">
        <property type="entry name" value="HAT_Syf1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="15">
        <location>
            <begin position="174"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor SYF1 central HAT repeats" evidence="13">
        <location>
            <begin position="399"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="14">
        <location>
            <begin position="555"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="964"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="974"/>
            <end position="1005"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037272"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00039472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETW85707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1203" mass="136433" checksum="8F96EC36662ACC32" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJ60</accession>
    <name>W4KJ60_HETIT</name>
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        <recommendedName>
            <fullName evidence="8">Vacuolar import and degradation protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_457537</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="ETW85882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009544397.1"/>
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        <property type="interactions" value="10"/>
    </dbReference>
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    <dbReference type="GeneID" id="20676845"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_457537"/>
    <dbReference type="eggNOG" id="ENOG502RGMX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006074_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJ60"/>
    <dbReference type="OrthoDB" id="5364245at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like_sf"/>
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        <property type="entry name" value="E1A-BINDING PROTEIN P400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459">
        <property type="entry name" value="E1A-BINDING PROTEIN P400-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="359"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="784"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="38"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="105"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="258"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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            <end position="484"/>
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="9">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="844"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="907"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1072"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="272"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="435"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="471"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="508"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="548"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="671"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="913"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="945"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW85882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1172" mass="131126" checksum="BC17D4DE4EA794AE" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJ76</accession>
    <name>W4KJ76_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_457302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542225.1">
        <property type="nucleotide sequence ID" value="XM_009543930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJ76"/>
    <dbReference type="GeneID" id="20676812"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_457302"/>
    <dbReference type="HOGENOM" id="CLU_767388_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJ76"/>
    <dbReference type="OrthoDB" id="3218963at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="361" mass="41811" checksum="1A1F5643B3479A2D" modified="2014-03-19" version="1">MSKTRRITHCGYSSARSRNRAASERVLVFPGAPLLPTELIYEITTLALSDYLTDLFISPHSILEWDGITVLLQSTSQIRSCTMKLLGFLDKETFINDKDRVSRMANYFPVLSPLRQLSRLAYCTPQAAFTPPKPKFLDDRAIRRPITRFPRMAGFVLQNFARTQVFVKRGMRCIRIREATYVLEQLRTFRDDYMAVHAVVRGALLGRVVEQLVERLGVWQRMLAIELTVRPFFQQISFIEELRHMLDLAQPIPPHMLATTVPFPPQSQIPAYVRIHEMLSTFFEVERKQLPSVTKEELGRVWFFTTLRYLRSGPSGEFGALLSKLLRCCIRPLFSPDDRALYFDENFDFEQDGLYGHFISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJI2</accession>
    <name>W4KJI2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_448940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542805.1">
        <property type="nucleotide sequence ID" value="XM_009544510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJI2"/>
    <dbReference type="STRING" id="747525.W4KJI2"/>
    <dbReference type="GeneID" id="20675898"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_448940"/>
    <dbReference type="eggNOG" id="ENOG502SX4V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1806407_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJI2"/>
    <dbReference type="OrthoDB" id="3254913at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="143" mass="15258" checksum="99D23B2DE0CFB241" modified="2014-03-19" version="1">MSTDKVDLPHDRSHVEASPSHQKYASSSTLADDQAETSSLPPLPEIPAPDLDLSLSLESIIGQSFPTSDKVSKRASNVLKLSEENEKLKQELRAMSERLEAAERRRVELDRRAREKKAAAAAAAAATTTTAATTGSNATAATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKS4</accession>
    <name>W4KKS4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_412908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540474.1">
        <property type="nucleotide sequence ID" value="XM_009542179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKS4"/>
    <dbReference type="GeneID" id="20673076"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_412908"/>
    <dbReference type="HOGENOM" id="CLU_1267034_0_0_1"/>
    <dbReference type="InParanoid" id="W4KKS4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="218" mass="24600" checksum="57A3A6F0BFB1C73C" modified="2014-03-19" version="1">MAKRTVTKSNPLPNFPNKPSLYTDMSSSSLSHLLNGNHHLSPLSLLVPEPFHTLPMTNIHNALPYPNADPFPGNRLPPIPDFNDAAACKHEVHCLTDTPSPRTRLLSDWLNHVCAAEQVGPMLPAHLPAPPSNWQNGAPRNFIQDYKAYEEGIKRLSMQLDHVAENFGYYWHIRERMIDNAAWEGHLVHHAPTFDILTIYGYIKELRSMNNDCGLLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLT6</accession>
    <name>W4KLT6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable quinone oxidoreductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NADPH:quinone reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">qor1</name>
        <name evidence="6" type="ORF">HETIRDRAFT_121361</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540772.1">
        <property type="nucleotide sequence ID" value="XM_009542477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLT6"/>
    <dbReference type="FunCoup" id="W4KLT6">
        <property type="interactions" value="359"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KLT6"/>
    <dbReference type="GeneID" id="20666749"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_121361"/>
    <dbReference type="eggNOG" id="KOG1197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_1_1"/>
    <dbReference type="InParanoid" id="W4KLT6"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05286">
        <property type="entry name" value="QOR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000053">
        <property type="entry name" value="Quinone oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047618">
        <property type="entry name" value="QOR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF13">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="19"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00070796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW86788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="342" mass="37253" checksum="744B27D5AE11F620" modified="2014-03-19" version="1">MSYPSTVKAVAIAKTGGFEVIEDMTLPFPEQKPGDVLVKVQYAGVNFIDTYFRAGVYPTPFLPFHMAKEISGVIAELPKDEATLNNEVYKKRNLRKGDRIAADLLGGLQEYVTVPWDAVYPIPKDVSNRVAAAALLQGITALSLMTESHNVQKGETILIHTVAGGVGLLMAQVAKARGATVIGTTSTPEKAELAKAHGADHVILYKNENTVERVSQLTNGQGPHVIYDGVGKDTFEDDLKMIRRKGTLISFGNASGLVPPFSIVRLNQKNLKLLRPTETNYTVTLEEREYYGAQLFDLISKGDLKVNIFGDYPFTAKGVRQAQLDLTGGKTTGKLIVKVSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLW1</accession>
    <name>W4KLW1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_166334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540801.1">
        <property type="nucleotide sequence ID" value="XM_009542506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLW1"/>
    <dbReference type="GeneID" id="20668047"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_166334"/>
    <dbReference type="HOGENOM" id="CLU_2292050_0_0_1"/>
    <dbReference type="InParanoid" id="W4KLW1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="101" mass="10959" checksum="C9AC64D3D0463391" modified="2014-03-19" version="1">MCPIPVTSQQPIRATGIFYTVISCSLPRTAPTGVTSVNPNSARFLARRLCSAKIIPRPLRQCLGGNGSDSLCFTTDCSRMPAPPYSSVFPSETRQTEMLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMA4</accession>
    <name>W4KMA4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_166020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540524.1">
        <property type="nucleotide sequence ID" value="XM_009542229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMA4"/>
    <dbReference type="GeneID" id="20668034"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_166020"/>
    <dbReference type="HOGENOM" id="CLU_3002005_0_0_1"/>
    <dbReference type="InParanoid" id="W4KMA4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="57" mass="5800" checksum="480957F5F8416133" modified="2014-03-19" version="1">MSFASGADIVALQTEVNVLCNTLKGIVSAIPNIVGLSNATLPKDFTMPDPAAPTNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KME4</accession>
    <name>W4KME4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_306944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540940.1">
        <property type="nucleotide sequence ID" value="XM_009542645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KME4"/>
    <dbReference type="GeneID" id="20669444"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_306944"/>
    <dbReference type="HOGENOM" id="CLU_050560_0_0_1"/>
    <dbReference type="InParanoid" id="W4KME4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="479" mass="52842" checksum="1110C834E9B303CA" modified="2014-03-19" version="1">MLLHDDHDASSPSRNSSPDVVLMVANPDVERVERGTSPHRPDAGRIDRGTSPQQPGPTGVLLTPHLNNFSDDDTEDYAKFKERERTRRPSPERASRDAPRHENPDDRNQSSLGQLPVGVPPPSEGTPNSGVAGPSGFRARTAAQLPSHGEVEPIPVLSETAPPPVPTSGPIPSSMGGPTPRTDPHAGELERHADALLQRNTISAVIQMATAMALQRLANFSAGQPGNEHSDVPRRLASASLQIRTLALQTDPDTASWYAHNDGRPRALLIHPDEFSQYVNRELLPALLFGGELGNVQPSRTDPFRVVTWNVPRPGEHPTPVPNPRRFPRTVVERPPPRQREVPTAHSHTATPPSHWIRGLPLSQGNTDEEEPPVYRRNEGRRGRGSQATLGRGTTAGRSVRHRPRSPPPSARFRTNEREDNRSSRRTRRVDSEARRNSSWTRSELDAWDALDDPGNYDEADPYYRPDEGGGDYQGPFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4KML7</accession>
    <name>W4KML7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_306015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541031.1">
        <property type="nucleotide sequence ID" value="XM_009542736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KML7"/>
    <dbReference type="GeneID" id="20669367"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_306015"/>
    <dbReference type="HOGENOM" id="CLU_088618_3_1_1"/>
    <dbReference type="InParanoid" id="W4KML7"/>
    <dbReference type="OrthoDB" id="5316007at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052479">
        <property type="entry name" value="GPI-anchor_Adhesion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185">
        <property type="entry name" value="SERINE/THREONINE-RICH PROTEIN ADG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185:SF1">
        <property type="entry name" value="UPF0619 GPI-ANCHORED MEMBRANE PROTEIN C1322.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845595" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="3">
        <location>
            <begin position="21"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW87088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="115" mass="12829" checksum="10ED40E3F68564C2" modified="2014-03-19" version="1">MRVFLALLSLAATTFAYQVTSPNSQEIWYSHGPVTVSWQRVDTDAEYFTMVLYNDKYQTLQTLAPKVDGKLGKTTIYPSGALPVGEGYQVNFVQDPSHLHNILAQSSAFKIQPSK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2024-03-27" modified="2025-04-09" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMP1</accession>
    <name>LP9B_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AA9 family lytic polysaccharide monooxygenase B</fullName>
            <shortName evidence="4">LPMO9B</shortName>
            <ecNumber evidence="3">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cellulase LPMO9B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Endo-beta-1,4-glucanase LPMO9B</fullName>
            <shortName evidence="5">Endoglucanase LPMO9B</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycosyl hydrolase 61 family protein LPMO9B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LPMO9B</name>
        <name type="ORF">HETIRDRAFT_166613</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>TC 32-1</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2018" name="FEBS J." volume="285" first="2225" last="2242">
            <title>Structural and molecular dynamics studies of a C1-oxidizing lytic polysaccharide monooxygenase from Heterobasidion irregulare reveal amino acids important for substrate recognition.</title>
            <authorList>
                <person name="Liu B."/>
                <person name="Kognole A.A."/>
                <person name="Wu M."/>
                <person name="Westereng B."/>
                <person name="Crowley M.F."/>
                <person name="Kim S."/>
                <person name="Dimarogona M."/>
                <person name="Payne C.M."/>
                <person name="Sandgren M."/>
            </authorList>
            <dbReference type="PubMed" id="29660793"/>
            <dbReference type="DOI" id="10.1111/febs.14472"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 20-244 IN COMPLEX WITH COPPER AND CELLULOSE ANALOG</scope>
        <scope>COFACTOR</scope>
        <scope>DISULFIDE BONDS</scope>
        <scope>GLYCOSYLATION AT ASN-152 AND ASN-233</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Lytic polysaccharide monooxygenase (LPMO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding specifically C1 oxidation product (PubMed:29660793). Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate (PubMed:29660793). Displays catalytic activity on insoluble cellulose using I-beta microfibril model substrate (PubMed:29660793).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
        <text evidence="3">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="biotechnology">
        <text evidence="3">Lignocellulose is the most abundant polymeric composite on Earth and is a recalcitrant but promising renewable substrate for industrial biotechnology applications. Together with cellobiose dehydrogenases (CDHs) an enzymatic system capable of oxidative cellulose cleavage is formed, which increases the efficiency of cellulases and put LPMOs at focus of biofuel research.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="3"/>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PDB" id="5NNS">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.10 A"/>
        <property type="chains" value="A/B=20-244"/>
    </dbReference>
    <dbReference type="PDBsum" id="5NNS"/>
    <dbReference type="AlphaFoldDB" id="W4KMP1"/>
    <dbReference type="SMR" id="W4KMP1"/>
    <dbReference type="STRING" id="747525.W4KMP1"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_166613"/>
    <dbReference type="eggNOG" id="ENOG502SJF0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031730_1_1_1"/>
    <dbReference type="InParanoid" id="W4KMP1"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF19">
        <property type="entry name" value="GLYCOSYLHYDROLASE FAMILY 61-8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0136">Cellulose degradation</keyword>
    <keyword id="KW-0186">Copper</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0503">Monooxygenase</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0624">Polysaccharide degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844531" description="AA9 family lytic polysaccharide monooxygenase B">
        <location>
            <begin position="20"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 9">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 9">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>(1,4-beta-D-glucosyl)n</name>
            <dbReference type="ChEBI" id="CHEBI:18246"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 9">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 9">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>(1,4-beta-D-glucosyl)n</name>
            <dbReference type="ChEBI" id="CHEBI:18246"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 9">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>(1,4-beta-D-glucosyl)n</name>
            <dbReference type="ChEBI" id="CHEBI:18246"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 9">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>(1,4-beta-D-glucosyl)n</name>
            <dbReference type="ChEBI" id="CHEBI:18246"/>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3 9">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3 9">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3 9">
        <location>
            <begin position="68"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3 9">
        <location>
            <begin position="111"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="strand" evidence="10">
        <location>
            <begin position="23"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="strand" evidence="10">
        <location>
            <begin position="31"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="strand" evidence="10">
        <location>
            <begin position="47"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="turn" evidence="10">
        <location>
            <begin position="64"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="helix" evidence="10">
        <location>
            <begin position="76"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="strand" evidence="10">
        <location>
            <begin position="82"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="strand" evidence="10">
        <location>
            <begin position="89"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="strand" evidence="10">
        <location>
            <begin position="104"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="helix" evidence="10">
        <location>
            <begin position="120"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="strand" evidence="10">
        <location>
            <begin position="125"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="strand" evidence="10">
        <location>
            <begin position="133"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="turn" evidence="10">
        <location>
            <begin position="138"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="strand" evidence="10">
        <location>
            <begin position="141"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="helix" evidence="10">
        <location>
            <begin position="144"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="turn" evidence="10">
        <location>
            <begin position="151"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="strand" evidence="10">
        <location>
            <begin position="154"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="strand" evidence="10">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="strand" evidence="10">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="helix" evidence="10">
        <location>
            <begin position="204"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="turn" evidence="10">
        <location>
            <begin position="210"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="turn" evidence="10">
        <location>
            <begin position="219"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="helix" evidence="10">
        <location>
            <begin position="225"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q1K8B6"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="29660793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="29660793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <evidence type="ECO:0000305" key="6">
        <source>
            <dbReference type="PubMed" id="29660793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW87087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="9">
        <source>
            <dbReference type="PDB" id="5NNS"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="5NNS"/>
        </source>
    </evidence>
    <sequence length="244" mass="25744" checksum="0B9FD48C83A7538A" modified="2014-03-19" version="1" precursor="true">MFLVPLLAALSLSAPKVAAHGGVLAYSLAGTWYNGFVPYNTPTGQSTIQREWDTYNPITDPTDASISCNINGASLGSAQKSATVAAGSSVTAYWNQWPHTIGPVMVYMANCGGDCTTATTSSLEWFKINQVGLVSGTLTSGTWGMGQLVANNNSWTTSIPSSLAAGNYILRHELLAIHTSNQPQFYPECAQLIVTGGEGATPPASYLVKLPGAYSMSDPGVNIDIYSHETETNYTIPGPAVWQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMU9</accession>
    <name>W4KMU9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_437525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540703.1">
        <property type="nucleotide sequence ID" value="XM_009542408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMU9"/>
    <dbReference type="GeneID" id="20674959"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_437525"/>
    <dbReference type="HOGENOM" id="CLU_1678121_0_0_1"/>
    <dbReference type="InParanoid" id="W4KMU9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="157" mass="16333" checksum="66846176C3739803" modified="2014-03-19" version="1">MSKAADTPPIEPVDSATLPAPGEVAEPAVGTNAEEPGLHPLGDEGEESDEYDDIENEEDEEAGGFEDDDEDGEEEDNSKEANDKGSLTALLLGGSQGGAEEEEEEDYEEDVEENVTAKGDGPKPTEGLASVGAKRGREESAEAPNGGAAQDAKKVKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMZ9</accession>
    <name>W4KMZ9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MRH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_99194</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540739.1">
        <property type="nucleotide sequence ID" value="XM_009542444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMZ9"/>
    <dbReference type="FunCoup" id="W4KMZ9">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KMZ9"/>
    <dbReference type="GeneID" id="20678895"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_99194"/>
    <dbReference type="eggNOG" id="KOG4504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1129174_0_0_1"/>
    <dbReference type="InParanoid" id="W4KMZ9"/>
    <dbReference type="OrthoDB" id="4504960at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028927">
        <property type="entry name" value="Man-6-P_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF0">
        <property type="entry name" value="MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02157">
        <property type="entry name" value="Man-6-P_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="19"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW86750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="246" mass="27105" checksum="C158CFF05A4CD99D" modified="2014-03-19" version="1">MLRQKNNRVQLTGVAGTMIYGPFSRGVVHETWNPDVAHPENIAAFTRRGHGDFSLGEVNTTLLVRDRHPLLILTGGSPCTGADHLRASTAVRFICDTSVFGSGKPRLVAQLPPNDESACAFFIEWRTHLACPTSEPSGFWGGLIVGMSMIALVLVMLYLVGGTLYRRYVLQQRGFDQIPRVSSLDNMRVLGTMETVLAQASNDCRPFQKKRKQFWDQKATGKATGILSQMTPRERVIGTRASQAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4KP40</accession>
    <name>W4KP40_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRELI/MSF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_31570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540297.1">
        <property type="nucleotide sequence ID" value="XM_009542002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KP40"/>
    <dbReference type="FunCoup" id="W4KP40">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KP40"/>
    <dbReference type="GeneID" id="20670246"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_31570"/>
    <dbReference type="eggNOG" id="KOG3336">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067902_1_1_1"/>
    <dbReference type="InParanoid" id="W4KP40"/>
    <dbReference type="OrthoDB" id="407630at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="182" mass="20797" checksum="89C0C1535FE93E57" modified="2014-03-19" version="1">MHYFSQSFTYDHSWAHVIIGMWHKYPNPHCSHVVTVDVVDRSVDPRTGIIRTERILGCKQRAPGWIVKLFGGSEDAFVREISFVDPSTQSTTISSVNLSLSQFATCFESIRYSPAPNGRTHFHQTAEIQARMAMWRSMADKLENWLAHRFEQNAQLGKVGFTDVLRNLWEEAKDSQPARVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPT3</accession>
    <name>W4KPT3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_413881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541695.1">
        <property type="nucleotide sequence ID" value="XM_009543400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPT3"/>
    <dbReference type="GeneID" id="20673140"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_413881"/>
    <dbReference type="HOGENOM" id="CLU_2236935_0_0_1"/>
    <dbReference type="InParanoid" id="W4KPT3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="105" mass="11784" checksum="4DC1797027B64D17" modified="2014-03-19" version="1">MKSGRSLHEAQRELHTTASRRIPLGHRDGQVVPSKSGWPDVHVSDYREKKQLTSTVVTARAADLRTTSKKRQMCQGLPAYTTEQRRLGVPDASALRPLLMFFRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPW3</accession>
    <name>W4KPW3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_306695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541689.1">
        <property type="nucleotide sequence ID" value="XM_009543394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPW3"/>
    <dbReference type="GeneID" id="20669429"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_306695"/>
    <dbReference type="HOGENOM" id="CLU_2359987_0_0_1"/>
    <dbReference type="InParanoid" id="W4KPW3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW87832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="96" mass="10917" checksum="6118B68390D44FC0" modified="2014-03-19" version="1">MFCYPLFFSGTPPLSIHFVNHRPCRVVNPAAALELRRSNAQTQANVIFLIPAPPRRRCSENSIRKWTISFGDLSHELTECGYEARIVHHLLPPGFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4KQ73</accession>
    <name>W4KQ73_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_482848</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541691.1">
        <property type="nucleotide sequence ID" value="XM_009543396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KQ73"/>
    <dbReference type="STRING" id="747525.W4KQ73"/>
    <dbReference type="GeneID" id="20678059"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_482848"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_2_3_1"/>
    <dbReference type="InParanoid" id="W4KQ73"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF2">
        <property type="entry name" value="BETA-GLUCOSIDASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844391" description="beta-glucosidase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="12">
        <location>
            <begin position="650"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW87834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="730" mass="77790" checksum="D2E72A611AE4D64C" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W4KQN6</accession>
    <name>W4KQN6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Heterotrimeric G protein alpha subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_378879</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="ETW87715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541582.1">
        <property type="nucleotide sequence ID" value="XM_009543287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KQN6"/>
    <dbReference type="STRING" id="747525.W4KQN6"/>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_378879"/>
    <dbReference type="eggNOG" id="KOG0082">
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    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF242">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="203"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="272"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW87715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="40847" checksum="208D3D147F8438C8" modified="2014-03-19" version="1">MGLCISSGPVDVTEEDKRRHREAEKALKDAKTKMNAQVKVLLLGSGDSGKSTILKQMRLIHRIPFSKQEVESYRQLVFNNLTHGLKYLLDAMEDMGLEVTSENVEHIEKVENAVDLRDGEPFPESYLDPLKLLWADESVQKAWERGNEAALPENLLYFFSDLDRLFALDYVPTEQDIVRCRARTIGITETVFQLKDHEMLMVDVGGQKSERRKWIHCFQDVTSILFLVSLSGYDQCLVEDKDANQMQDAMTIWDSICHSQWFKSTSIILFLNKNDLFEAKVQHSDIKSFFPDYDGEAADARAGRDYFKKRFARLAQKAGRSKEREIYIHITTATDTALLRVVMAAVEASFFDKILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4JM28</accession>
    <name>W4JM28_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_414121</name>
        <name evidence="2" type="ORF">HETIRDRAFT_423268</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="ETW84980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541877.1">
        <property type="nucleotide sequence ID" value="XM_009543582.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553089.1">
        <property type="nucleotide sequence ID" value="XM_009554794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JM28"/>
    <dbReference type="GeneID" id="20673152"/>
    <dbReference type="GeneID" id="20673894"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_414121"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_423268"/>
    <dbReference type="eggNOG" id="ENOG502QUVG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1938440_0_0_1"/>
    <dbReference type="OrthoDB" id="2144714at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007734859" description="Peroxidase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW74583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW84980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14057" checksum="F79989FDA1043968" modified="2014-03-19" version="1">MRAHISPLFLLLLPQNLIFSSFAFAPNPILVSNELEHLLVDTGGANDGGFKRAITPCTNYVEGSQLLGRETAAQWIRVAFHDFVTADVGTGVGGLDASIGFETLRAENSGTAMNDSLTFFAPFVNAQWRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMN5</accession>
    <name>W4JMN5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_157728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553284.1">
        <property type="nucleotide sequence ID" value="XM_009554989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JMN5"/>
    <dbReference type="GeneID" id="20667748"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_157728"/>
    <dbReference type="HOGENOM" id="CLU_2333864_0_0_1"/>
    <dbReference type="InParanoid" id="W4JMN5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW74807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="98" mass="11127" checksum="11BC813BD1261E70" modified="2014-03-19" version="1">MRASMEPPSDGAESLLFPVLNFLDFFSIDIHHQGTPEAPSLVHTISKSLKYRAAKAPLQTLHLHDCQARMEWVDDLRNTVPAEITETLVYPCYSLFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4JN43</accession>
    <name>W4JN43_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HpcH/HpaI aldolase/citrate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_332496</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553438.1">
        <property type="nucleotide sequence ID" value="XM_009555143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JN43"/>
    <dbReference type="GeneID" id="20671736"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_332496"/>
    <dbReference type="eggNOG" id="ENOG502SJMS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059964_2_1_1"/>
    <dbReference type="InParanoid" id="W4JN43"/>
    <dbReference type="OrthoDB" id="1621678at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF8">
        <property type="entry name" value="SYNTHASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="3">
        <location>
            <begin position="43"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW74982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="292" mass="31539" checksum="63EFEAD69C2CF486" modified="2014-03-19" version="1">MQHLRASSLFQPSNLSKAIRDTLDPSSRGPTHLFGSIMAFPHHVVARSVAVLGFDFVLIDALHTAIGPENLIRLVQTVNLASEGRTCAIVRVPNEHSYLLTHALDAGAAGIVFPHIDTPQQARIAVSKTKYAYSGGERSLSPSALIAGASDMAPEGSSHERVADEHVAVICQIESKLGLENAEAIALTPGVSSLMLGPGDMRVSLGLPSKRTGAFDSPEYLKVVQRLIAVSERHHVPLMTVTFKTSAKTDSWISKFRLLLTSADVISVSNGHRQDLSSTKQILRDYGYDERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNG1</accession>
    <name>W4JNG1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_57511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW75019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553070.1">
        <property type="nucleotide sequence ID" value="XM_009554775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNG1"/>
    <dbReference type="GeneID" id="20678398"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_57511"/>
    <dbReference type="HOGENOM" id="CLU_3002007_0_0_1"/>
    <dbReference type="InParanoid" id="W4JNG1"/>
    <dbReference type="OrthoDB" id="2729552at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW75019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="57" mass="6462" checksum="6C6B4CAC233D0DF5" modified="2014-03-19" version="1" fragment="single">ELLATNLGGEDVILGTDCLYEHNPQINWVKNRLTFSICARTCLVSRPKFMIQAQLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNL3</accession>
    <name>W4JNL3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_461401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553150.1">
        <property type="nucleotide sequence ID" value="XM_009554855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNL3"/>
    <dbReference type="GeneID" id="20677164"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_461401"/>
    <dbReference type="eggNOG" id="KOG2798">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030612_2_1_1"/>
    <dbReference type="InParanoid" id="W4JNL3"/>
    <dbReference type="OrthoDB" id="978at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF13">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW74655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="427" mass="46885" checksum="7461FF16B4F37DC5" modified="2014-03-19" version="1">MPRLTRVLAWALALTACASLWTLARRLSDSPLTLAITLPDGVHVHIDGARAPSVHAQHPHDPAPQGSPAAAALPPLREPYQSILTTITALEHYGEHTTSVLARKHARFARLPAAHAPYAAAIDYAGQFARADALVPVNAAVLSAIAGTARAAYGFEADEVTVRVRNEIVGDLVGHLVRDWSAEGREERERVIRPIVDALRSALPKNGQDQFRILVPGAGLGRLAHEIALEPDFHVDASELDYGSVLAYRYLANTTHTPAPLAHTFHPFLTDWSFQSNAADRFLPVRFPDALPNPTPADPPRVRMIDGDFLELAKAVQRDRERGEDTRYDAVATLFFIDVAENEVEFLQAIHSVLKPGGLWVNLGPFKWGTHSQLQLSAEEVLHLADMVGFAVDPTSRRAIDAVYAHQPGSLLKFTYVTQFWTARKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4JP22</accession>
    <name>W4JP22_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_412466</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552707.1">
        <property type="nucleotide sequence ID" value="XM_009554412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JP22"/>
    <dbReference type="GeneID" id="20673032"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_412466"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_2_1"/>
    <dbReference type="InParanoid" id="W4JP22"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF2">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="30"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW75273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="384" mass="42489" checksum="009D3D79E8E5681C" modified="2014-03-19" version="1">MSFFAPPPPPATGLGRYRVLSPLAGIRVSPLQLGAMSIGDKWKGMGAMNKESSFKLLDAYYEKGGNFIDTANGYQDEASEELIGEWMEARGIRDQLVIATKYTSNFKRGDPNVAQKVNYVGNSTKSLHISLTASLRKLRTSYIDVLYVHWWDWGTSVEETMRALHRVVLSGQVLYLGASDMPAWVVAKANQYARDHGMTPFSIYQGQWNVMKRSFEREIIPMAREEGLALAPWDVLGAGKIRTDAEEAARRETGENGRMTFNPDWERTPDERKVCAALEVVAGQVGVTSIQAVAIAYLMHKTTHVFPIIGGRKVEHLEANIAALDIALSPEQIAYLEAALPFDVGFPASMIGTGLEDPPLLKSAAHMDRWPLRQPILPVKKSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPH7</accession>
    <name>W4JPH7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH:ubiquinone reductase (non-electrogenic)</fullName>
            <ecNumber evidence="2">1.6.5.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_157534</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a quinone + NADH + H(+) = a quinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:46160"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a ubiquinone + NADH + H(+) = a ubiquinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:23152"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.9" evidence="2"/>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552856.1">
        <property type="nucleotide sequence ID" value="XM_009554561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPH7"/>
    <dbReference type="FunCoup" id="W4JPH7">
        <property type="interactions" value="184"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JPH7"/>
    <dbReference type="GeneID" id="20667732"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_157534"/>
    <dbReference type="eggNOG" id="KOG2495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021377_1_0_1"/>
    <dbReference type="InParanoid" id="W4JPH7"/>
    <dbReference type="OrthoDB" id="3244603at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) (non-electrogenic) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF47">
        <property type="entry name" value="EXTERNAL NADH-UBIQUINONE OXIDOREDUCTASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="11">
        <location>
            <begin position="131"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="External alternative NADH-ubiquinone oxidoreductase-like C-terminal" evidence="12">
        <location>
            <begin position="511"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
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        </location>
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            <begin position="18"/>
            <end position="28"/>
        </location>
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        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
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            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047599"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049010"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW75438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="579" mass="63426" checksum="8E17C05F46112795" modified="2014-03-19" version="1"> </sequence>
</entry>
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    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
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                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
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                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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                <person name="Grigoriev I.V."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
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            <end position="24"/>
        </location>
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            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW75300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="44984" checksum="FD7DFA2BA1D9FC64" modified="2014-03-19" version="1">MSSSNPPAYPQSPPYSPVPHPDETQLARASIRTRRSRPTGIFTTSKNGIVLALRGQEDGALIPSYGRNSTISGDIGLESTEDVVGVSVKLQGVLDLTVTGVASQDSIFLSKSSTIWEQANSSAHAPSMLPFEVAIPQSHQDAGSARPLPPTYAGVFPGVRDLHVKCCYTLTVYVTRSGLWKPRKSMSVQFAYQPRTRPHRPIISSPFPFSTTIRSHPEEWHQVSSTMRSRADSGVKPIECQLFIPAVRIYSITDTVPFYLQLCAPTASIDAFLHPRPPPPSMFRLSKAAVAFDDSAQPTVTVSFMRQIEAVVGSHHAFRSFVIGEGTLRPVPPDVASSTTLVPPADGYQTLNWEGEIKCQKNVTDVGFSDHVRLQLVPPSPKTSPLLEHEHLHTIRLVTDSFMEGREYDF</sequence>
</entry>
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    <name>W4JQR0_HETIT</name>
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        </submittedName>
    </protein>
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            <taxon>Bondarzewiaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
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                <person name="Yakovlev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="FunCoup" id="W4JQR0">
        <property type="interactions" value="322"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JQR0"/>
    <dbReference type="GeneID" id="20678011"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_482151"/>
    <dbReference type="eggNOG" id="KOG1673">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_0_2_1"/>
    <dbReference type="InParanoid" id="W4JQR0"/>
    <dbReference type="OrthoDB" id="6585768at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090068">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Septum-promoting GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR017231">
        <property type="entry name" value="Small_GTPase_Tem1/Spg1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037527">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW75420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="225" mass="24832" checksum="C01E8A8AD5CCBD10" modified="2014-03-19" version="1">MSNVASSSSSAQAASSSGTGQNAHPLLSNNDEKNSVVIKVGMVGDSQIGKTSLMVKYVEGSFDEDYIQTLGVNFMEKTISVRRTTITFSIWDLGGQREFVNMLPLVCNDAVAILFMFDLSRKSTLNSVKEWYRQARGFNKTAIPFLIGTKFDTFATFPRDEQEEITKQAKRFAKAMHASLIFCSTSASINVQKIFKIVLAKAFDLKCVIPEIEGVGEPVLIYVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQY9</accession>
    <name>W4JQY9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_446730</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552854.1">
        <property type="nucleotide sequence ID" value="XM_009554559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRE1"/>
    <dbReference type="GeneID" id="20666296"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_107997"/>
    <dbReference type="HOGENOM" id="CLU_1606598_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRE1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="166" mass="17170" checksum="E44AC3C136FF2DF2" modified="2014-03-19" version="1" fragment="single">MSSYPRRSRYAPPPTRRSTSFSDDDSIRPPPSSTAPSTPSTAPTLIPRLSPRSPSPLAPPRPAFLRSRPQSTRSGSSSNSYSYSQDSQTASLTPSVDTPSASDSEREMPPVVPPRARQRAHNRGRVGAAGPAAGRGTGTGAAAGGYTALNTDAHAPSPAPAPTPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRR8</accession>
    <name>W4JRR8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_430572</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552438.1">
        <property type="nucleotide sequence ID" value="XM_009554143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRR8"/>
    <dbReference type="GeneID" id="20674462"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_430572"/>
    <dbReference type="HOGENOM" id="CLU_078964_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRR8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="58"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW76233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="239" mass="27231" checksum="3DD16FCFD8B9E223" modified="2014-03-19" version="1">MSSSALLPLLNGTRHLSPLALPVPEPFSHLPMTDIHNALPYPYADPFPGNRLPPIPVFDDAGRPISRPSSPPYNPEQAAREHEVHHSTPVSPPRTINGWPLDGVRAAERTWPPLRDPSPSPPPLVLSPPATDTRLCWECNRPGHLIANCPITRIRRRTDLTARNFIRDYEAYGEVVELLSTQLEHVAENYRYYWHIRDRMIDDARWEGHPTRHTPVMDPRTFMALPIRDPDAVMSQRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4JS27</accession>
    <name>W4JS27_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spindle assembly checkpoint component MAD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_460753</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551276.1">
        <property type="nucleotide sequence ID" value="XM_009552981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JS27"/>
    <dbReference type="FunCoup" id="W4JS27">
        <property type="interactions" value="467"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JS27"/>
    <dbReference type="GeneID" id="20677108"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_460753"/>
    <dbReference type="eggNOG" id="KOG4593">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021480_0_0_1"/>
    <dbReference type="InParanoid" id="W4JS27"/>
    <dbReference type="OrthoDB" id="331602at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008672">
        <property type="entry name" value="Mad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168:SF0">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1 MITOTIC ARREST DEFICIENT-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05557">
        <property type="entry name" value="MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75704">
        <property type="entry name" value="Mitotic arrest deficient-like 1, Mad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="233"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="347"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="419"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="582"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW76357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="713" mass="81340" checksum="4F92C29809CE1E71" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSJ8</accession>
    <name>W4JSJ8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_328667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551337.1">
        <property type="nucleotide sequence ID" value="XM_009553042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSJ8"/>
    <dbReference type="STRING" id="747525.W4JSJ8"/>
    <dbReference type="GeneID" id="20671432"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_328667"/>
    <dbReference type="HOGENOM" id="CLU_177419_0_0_1"/>
    <dbReference type="InParanoid" id="W4JSJ8"/>
    <dbReference type="OrthoDB" id="2742659at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="78" mass="8965" checksum="0E0E1AC10F79C97A" modified="2014-03-19" version="1">MTRDWNEVIWTNEAKLELGERLGHRMIRSPGKEFLSKTIQPTFKSGHKSIMVWRCIAHGMKGPLIKLKFPPATMSEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTG0</accession>
    <name>W4JTG0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_106153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551623.1">
        <property type="nucleotide sequence ID" value="XM_009553328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTG0"/>
    <dbReference type="GeneID" id="20666135"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_106153"/>
    <dbReference type="HOGENOM" id="CLU_1256176_0_0_1"/>
    <dbReference type="InParanoid" id="W4JTG0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="220" mass="25023" checksum="A4BD5DC0843363ED" modified="2014-03-19" version="1">MLIQKASFQFSAASVSFFTLPSPRSLLHRCCDVAIADSTLLRRYFKGVVGFHHLIKNLLDTAYSARTRSWYTQSLRVVQAPNARYPFEVNMHDDAVLKLLKKHKGIEGPRADLNAQQNKRLVEPMKVLFDRHNPKDVSIKSTDGQTIISGLARPHSARALLAFIANSADASPYSYIGLSCKRTCYAFFRAYNRPGPNRLSTFKGLKWNFTSFSFFRQRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTK2</accession>
    <name>W4JTK2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Valine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="4">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HETIRDRAFT_389466</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="4"/>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551342.1">
        <property type="nucleotide sequence ID" value="XM_009553047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTK2"/>
    <dbReference type="FunCoup" id="W4JTK2">
        <property type="interactions" value="728"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JTK2"/>
    <dbReference type="GeneID" id="20672412"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_389466"/>
    <dbReference type="eggNOG" id="KOG0432">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_0_1_1"/>
    <dbReference type="InParanoid" id="W4JTK2"/>
    <dbReference type="OrthoDB" id="629407at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00817">
        <property type="entry name" value="ValRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000009">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000020">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000078">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000005">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004349">
        <property type="entry name" value="PRK05729.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="15">
        <location>
            <begin position="14"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="16">
        <location>
            <begin position="684"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETW76435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="963" mass="109052" checksum="B080DA0D57B5327F" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUD3</accession>
    <name>W4JUD3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_429929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009553090.1"/>
    </dbReference>
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    <dbReference type="STRING" id="747525.W4JUD3"/>
    <dbReference type="GeneID" id="20674395"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_429929"/>
    <dbReference type="eggNOG" id="ENOG502R1TU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032660_0_0_1"/>
    <dbReference type="InParanoid" id="W4JUD3"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844964" description="Amine oxidase domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="61438" checksum="98D8B485E7841DAA" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUG8</accession>
    <name>W4JUG8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_455065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551418.1">
        <property type="nucleotide sequence ID" value="XM_009553123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUG8"/>
    <dbReference type="STRING" id="747525.W4JUG8"/>
    <dbReference type="GeneID" id="20676581"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_455065"/>
    <dbReference type="eggNOG" id="KOG2495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019845_0_1_1"/>
    <dbReference type="InParanoid" id="W4JUG8"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF11">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="132"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="484" mass="51993" checksum="5770A98F508F4FB0" modified="2014-03-19" version="1">MTSTSPTSKPTLNIVIIGGSYVGCKAAELIAQRLQPYKRTHANTHIPHRILLIEQNSHFQHRFAFPRCAVVPGDELGLTDAIGAANGAETRKIGLEQFAFIPYTRMFAALESPDTSSSDANVTADTSVTVVHARATSILPSSIVLDPSSSPDDAPATPTTIPYDFLVLATGTQLTPPGVPPATNHGGTTKREGVAYYRAHQERVRSAESIVIVGGGAVGVQLATDLKEHYPNKHITLIHSRARLMHTFHPKLHAIIMQRVNDLGIDVVLEDRVIVPEGGFPGAVQLGADDHDSKPFEVALRSGRAISNVDFVILATGQTPQPVPISVSCHSDPESSTPTPIAIPASGYIPVLRTFQLAQPADSTRVAHPHIFAIGDAAATPHQKAARPGFAHAEIVSRNIEALILANANPSLDQSKSGDLKLEEYGELPGGIHLSLGKRHNVRFRESEEPGGEPWYKLSEDGAADMRVRKLWEARAPGIVDYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUH1</accession>
    <name>W4JUH1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_174607</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
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        <property type="protein sequence ID" value="ETW76531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551423.1">
        <property type="nucleotide sequence ID" value="XM_009553128.1"/>
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    <dbReference type="AlphaFoldDB" id="W4JUH1"/>
    <dbReference type="STRING" id="747525.W4JUH1"/>
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    <dbReference type="eggNOG" id="KOG0169">
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    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
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    </dbReference>
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        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF169">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="258"/>
            <end position="372"/>
        </location>
    </feature>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW76531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="520" mass="58086" checksum="C518FBCD41DE4343" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUS5</accession>
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        <lineage>
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            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="20669295"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_28761"/>
    <dbReference type="eggNOG" id="KOG0955">
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    </dbReference>
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    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bromodomain"/>
    </dbReference>
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        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Bromodomain_contain_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881:SF27">
        <property type="entry name" value="BROMODOMAIN CONTAINING 7_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881">
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    </dbReference>
    <dbReference type="Pfam" id="PF00439">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW76825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="70" mass="7772" checksum="7632E15457A4DFBA" modified="2014-03-19" version="1" fragment="single">FLEPVDPSKVAGYAEAIKRPMDFGTITTKVAKGKYRSLEEFAADFHLVISNAKSFNPPGTIYHAEAERIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVD7</accession>
    <name>W4JVD7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">General transcription factor TFIIB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_421573</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009552653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JVD7"/>
    <dbReference type="STRING" id="747525.W4JVD7"/>
    <dbReference type="GeneID" id="20673733"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_421573"/>
    <dbReference type="eggNOG" id="KOG1597">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043736_1_0_1"/>
    <dbReference type="InParanoid" id="W4JVD7"/>
    <dbReference type="OrthoDB" id="25790at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="6">
        <location>
            <begin position="13"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW77444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="337" mass="37163" checksum="E9E00D407EF622B2" modified="2014-03-19" version="1">MLYDYPFAPDLAVRLECKDCKNQQPNIVEDLHTGDCICGDCGLVLEARRVDTSVEWRTFADDDYSTNQSRVGDLYDVTAGATVDYGTFIDGDHGSSIAKSLQHTAIKTLSPEQRKRDSAFGRIQHWCDILDLPFTVSTSARRLWSSIQNQTKGANKEPIYAACIFVACQSNGAPRTYAEITNKMSIKEKSLNRWVKVLKKQSLSTSSSNTTNPEAILPRACTQLNLSQVIEMRCKTLIARYRELDLSGDHARSPLSIAGGVICFGSCLLGSSKAFTDVALAVGVTPRTVSDVYNVCFKRRTDLVPAEWIENGTASFARLPGHIIGQKSVSEPKPRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVE1</accession>
    <name>W4JVE1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_446593</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551690.1">
        <property type="nucleotide sequence ID" value="XM_009553395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JVE1"/>
    <dbReference type="STRING" id="747525.W4JVE1"/>
    <dbReference type="GeneID" id="20675696"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_446593"/>
    <dbReference type="eggNOG" id="KOG2251">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033345_0_0_1"/>
    <dbReference type="InParanoid" id="W4JVE1"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052631">
        <property type="entry name" value="Paired_homeobox_Bicoid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46255:SF3">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46255">
        <property type="entry name" value="SHORT STATURE HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="72"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="74"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="319"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="363"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW76821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="480" mass="51064" checksum="1CEE3D4BE9D4A537" modified="2014-03-19" version="1">MKRRFSEEKYEHESRSSPSVSSSHGEGGLADTETDANPSHSDAGPSQLSGIPSRSQLQETGIQAQQAAPPPQKKKRTRTLTTPHQSAVLHALLAQSRFPTTAMREEVGRSIGLSARKVQNQRQKARRPRSQSAVPPLTRPPQYGPFANSPSSAPAMTQTPYTSAPLGSASSYSTFSGHSGQHSAGHDHYHPEGYTHHRTGASSSPTTRLSGPGVPGPSTPFAPRLHPAPQPLGPPPPGYIPSSGYAEHWSPHEPPFGHAHGASLSVDPRQTPPVQREYAIQLPPLVLDERQHTGTSRSSFPPLAPPPFPSAPPHLDAFQPSSLRSPFNATPNSPFSPYPPRGLSHEPGSSSRILPRLHIPTPYAQSSPRRNPTSLSPYALAGPSASSSTSGGAFIRNTMTSIGRPEPPTLSLAPVAPSWRISSPRPPSPSPRLSSSRTATPPPRPARFDPVRAAQNENNGGGFQNTGPPARRTPPDHTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVJ0</accession>
    <name>W4JVJ0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_436369</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="5"/>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551071.1">
        <property type="nucleotide sequence ID" value="XM_009552776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JVJ0"/>
    <dbReference type="FunCoup" id="W4JVJ0">
        <property type="interactions" value="629"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JVJ0"/>
    <dbReference type="GeneID" id="20674886"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_436369"/>
    <dbReference type="eggNOG" id="KOG1358">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_0_2_1"/>
    <dbReference type="InParanoid" id="W4JVJ0"/>
    <dbReference type="OrthoDB" id="3168162at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
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        </source>
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        <source>
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</entry>
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                <person name="Asiegbu F."/>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
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                <person name="Yakovlev I."/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
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            <end position="415"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="1118"/>
        </location>
    </feature>
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            <end position="1316"/>
        </location>
    </feature>
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        </location>
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        <location>
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            <end position="1477"/>
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        <location>
            <begin position="1489"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        <location>
            <begin position="36"/>
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            <begin position="92"/>
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        </location>
    </feature>
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            <begin position="262"/>
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        </location>
    </feature>
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        <location>
            <begin position="535"/>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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            <end position="1012"/>
        </location>
    </feature>
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        <location>
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            <end position="1239"/>
        </location>
    </feature>
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        <location>
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            <end position="1553"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW77582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
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                <person name="Hogberg N."/>
                <person name="James T.Y."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD40_rpt"/>
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</entry>
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                <person name="Lin Y.C."/>
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</entry>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="80" mass="8356" checksum="E3B19D9C12081C67" modified="2014-03-19" version="1">MYLQLHGAQAAGGRRGPPRSAACTGEDTNRQAGRIERGGVESDRDRDRDRDRNGGGTATGAGLRRGRDCDGGGTATDFGH</sequence>
</entry>
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                <person name="Yakovlev I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="747525.W4JXP6"/>
    <dbReference type="GeneID" id="20667872"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_163823"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_395901_0_0_1"/>
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    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="381"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="188"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="282"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="422"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW77845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="696" mass="73364" checksum="9931E083FB30B44F" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXR6</accession>
    <name>W4JXR6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha-ketoglutarate-dependent dioxygenase AlkB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_127322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009552002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXR6"/>
    <dbReference type="STRING" id="747525.W4JXR6"/>
    <dbReference type="GeneID" id="20666988"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_127322"/>
    <dbReference type="eggNOG" id="KOG4176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080229_1_0_1"/>
    <dbReference type="InParanoid" id="W4JXR6"/>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AlkB-like"/>
    </dbReference>
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        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032870">
        <property type="entry name" value="ALKBH7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052:SF0">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052">
        <property type="entry name" value="SPERMATOGENESIS ASSOCIATED 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-ketoglutarate-dependent dioxygenase AlkB-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="214" mass="24154" checksum="C56507AFBB3617AA" modified="2014-03-19" version="1">MFFPKFLDLTEQHTLLHAALHKLDSLENRALRRRRKDFLSTRSPIPETAQTVEDFFPDQYYDFHEGHFDGVIKHFRETHVSSWGNADSPALSAVIDRLRTLYPSDSETQMHVLHLASDGEILPHVDNVGASGSWILGVSLGATRVLRLEDTDDAAPRAPFNLPLPSGSVYIQRDSIRYGYKHSILRAEDPSRGQRLSVMVRDILPKGANIPLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4JY42</accession>
    <name>W4JY42_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_454399</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550430.1">
        <property type="nucleotide sequence ID" value="XM_009552135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JY42"/>
    <dbReference type="FunCoup" id="W4JY42">
        <property type="interactions" value="276"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JY42"/>
    <dbReference type="GeneID" id="20676505"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_454399"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_1_1"/>
    <dbReference type="InParanoid" id="W4JY42"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019413">
        <property type="term" value="P:acetate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="33"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW78463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="499" mass="54000" checksum="9E03E9594AA91875" modified="2014-03-19" version="1">MSTFTHNFDTPVYKAKISFPTGVFIDGKFSQGSTGKTLDVINPTNGKVITSVDEATAADVDRAVVAAHKAFNTTWGLHAPGATRAALLNKLGNLMVEHYDELAAIEALDNGKTFGWAKAADLSLAVETIKYYAGWADKIQGNVIETTEDKLAYTRHEPIGVVGQILPWNFPLMLMCWKLGPALATGNCVVIKPSEFTPLTALRMASLINEAGFPPGVVNILVGYGTTVGVAISAHMDIEKISFTGSTLVGRKVMEAAANSNLKDTTLELGGKSPNIIFNDADLDLAVNWSSHGIFWNHGQACCAGSRIFVQSGIYDEFLKRFTEKAQSLKLGDPFAVDSYQGPQVSQGQYDRIMSYIDSGKSEGATLHLGGQRHGDEGYWIQPTIFTNTKPNMKIVQEEIFGPVGVVIKFEDEEDVVHQANDSMYGLAAAIFTQDITRGLQMAHKLKAGTAWINCANQLHAAIPFGGFKQSGVGRELGEYALLHYTSVKAVHVNLGHKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYK3</accession>
    <name>W4JYK3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_441447</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549955.1">
        <property type="nucleotide sequence ID" value="XM_009551660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYK3"/>
    <dbReference type="FunCoup" id="W4JYK3">
        <property type="interactions" value="389"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JYK3"/>
    <dbReference type="GeneID" id="20675366"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_441447"/>
    <dbReference type="eggNOG" id="KOG0417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_13_3_1"/>
    <dbReference type="InParanoid" id="W4JYK3"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000010">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2-16 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW77941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="147" mass="16399" checksum="0644AFB2E2C543C9" modified="2014-03-19" version="1">MALKRINKELIDLGRDPPSSCSAGPTGDNMFQWQATIMGPGDSPYAGGVFFLSITFPTDYPFKPPKVSFTTKIYHPNINANGSICLDILRDQWSPALTISKVLLSICSMLTDPNPDDPLVPDIAHLYKTDRARYEATAREWTRKYAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYK4</accession>
    <name>W4JYK4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_117392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548865.1">
        <property type="nucleotide sequence ID" value="XM_009550570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYK4"/>
    <dbReference type="GeneID" id="20666553"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_117392"/>
    <dbReference type="HOGENOM" id="CLU_1354772_0_0_1"/>
    <dbReference type="InParanoid" id="W4JYK4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="202" mass="23330" checksum="BA700BDF40F223DD" modified="2014-03-19" version="1">MIYLCSARQKYLRGKITRETNGQEAGWMAEPDKVEGQSRYRTPPVEHTSDGYLTDTPRAREFMLSPLLAGCTSPKVERRTCGSSLYEDPTARMIRCHNQGGWLLQVMQKGARRMHVIENDWAMTVALYIPESEYALWDRKRTYPHSARNARCKHEVLNTWSTFKDHRVIRTLEKIKISLEDYVLLSTSTTVVVLAHYESAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZI8</accession>
    <name>W4JZI8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_117592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549170.1">
        <property type="nucleotide sequence ID" value="XM_009550875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZI8"/>
    <dbReference type="GeneID" id="20666556"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_117592"/>
    <dbReference type="HOGENOM" id="CLU_1949088_0_0_1"/>
    <dbReference type="InParanoid" id="W4JZI8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="129" mass="14151" checksum="02DDFA7938F6D9C2" modified="2014-03-19" version="1">MWKPTTGSDLINTYYNTSVRSWCMLITMPVLATAPMLATVPVLATAPVLTTMPALATTPALTTAPALTTAPALMAPPIVNIYRSLCQLDPLVPPLARSLQHLLHPNHSNYLRQWTRYKQMEHDVVASTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZS0</accession>
    <name>W4JZS0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_441125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549256.1">
        <property type="nucleotide sequence ID" value="XM_009550961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZS0"/>
    <dbReference type="GeneID" id="20675329"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_441125"/>
    <dbReference type="HOGENOM" id="CLU_2197323_0_0_1"/>
    <dbReference type="InParanoid" id="W4JZS0"/>
    <dbReference type="OrthoDB" id="3209478at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="108" mass="12401" checksum="23FE9509B197F672" modified="2014-03-19" version="1">MGNRSSIKLDIWLGGYRRWEKQIQTKDDTAARKPITFEKLVTHVANRVKDFLESGERDPTRQMDLEWTIKGMNQTVQEAHEISVENLALIGVTFVSQGAIMPLLQRMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZS4</accession>
    <name>W4JZS4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lipase, class 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_35715</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548731.1">
        <property type="nucleotide sequence ID" value="XM_009550436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZS4"/>
    <dbReference type="GeneID" id="20671800"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_35715"/>
    <dbReference type="eggNOG" id="KOG4569">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032957_9_1_1"/>
    <dbReference type="InParanoid" id="W4JZS4"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF25">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004843994" evidence="5">
        <location>
            <begin position="20"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="6">
        <location>
            <begin position="108"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW78590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="318" mass="33227" checksum="7776EAF099F6571D" modified="2014-03-19" version="1">MFSLPSTFALLALPILVRAAPLQDRSSNSLSTQTVSASTISSAFVRPAQFARIAYCSSEAVEKWDCGAPCQALGMNGVTPLVVGGGRTDGGATPRFFVSYDSKTSSIVVAHQGTDASNVLSIINDAQFLKTDINQTLFPKAGDDVQVHDGFSKAHGRTADTVLATVKAGLAKNNASKIAVTGHSLGAAIATMDAVMLRQNLGPSVEISTVVFGLPRGGNQAWADLVDSELGGNFTFITHKDDPVPLVPPRFIGYQHSAGEVHIKETDDKTGEASVTVACPGQENENCIDGNSLLSTSISDHIGPYFANVSMSGSNCPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0F3</accession>
    <name>W4K0F3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_147306</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549096.1">
        <property type="nucleotide sequence ID" value="XM_009550801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0F3"/>
    <dbReference type="FunCoup" id="W4K0F3">
        <property type="interactions" value="351"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K0F3"/>
    <dbReference type="GeneID" id="20667192"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_147306"/>
    <dbReference type="eggNOG" id="KOG1441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019048_3_1_1"/>
    <dbReference type="InParanoid" id="W4K0F3"/>
    <dbReference type="OrthoDB" id="1588579at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="16"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="392"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW78790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="440" mass="47013" checksum="36553E2654E92FC6" modified="2014-03-19" version="1">MSPLVRFSRLRRPTRAILRDTVPMGLFQVGGHIFSSMAISRIPVSTVHTIKALSPLFTVAAYALMFGVRYSAKTYVSLLPLTLGVMLACTFDMSISNGIGFLCALGSALIFVSSNIFFKKVMPTGADAHAHHKLDKLNLLFYSSSMAFLLMIPIWLYADLGALLASASAEPGHVAHPSHGHSAPHSVAYYLVANGTVHFAQNIVAFVILASVSPVTYSIASLFKRVAVICMALVWFSQRVHPVQAGGIALTFVGLWMYNNAKGDVARGENKRRGVEARREGMLPTTREEEKILAGGTTPPSEPIHYHPSQHQHQHQHQHQHQLPLRPAPADAGVSLASGRTRALSQLAAPLRTKMETHAPLHAPERRAHAHPNLHIEIIPPSPGAGPIAIAVPGSGALPGGGKGARPSSPTELYPSPPLSLDSPPLTSAGLAPVPVPARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0F6</accession>
    <name>W4K0F6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_387609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0357 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549528.1">
        <property type="nucleotide sequence ID" value="XM_009551233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0F6"/>
    <dbReference type="FunCoup" id="W4K0F6">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="GeneID" id="20672320"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_387609"/>
    <dbReference type="eggNOG" id="ENOG502S73R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128832_2_0_1"/>
    <dbReference type="InParanoid" id="W4K0F6"/>
    <dbReference type="OrthoDB" id="447314at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018559">
        <property type="entry name" value="DUF2015"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023:SF1">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09435">
        <property type="entry name" value="DUF2015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW79283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="129" mass="14569" checksum="ED4E42573FC3AAF2" modified="2014-03-19" version="1">MLFYLSLLALTALLVMLLYRYRSTLPFPQRLRSFLSHPSSNNYAPLSTFADQAAAGMSSSTFDVESDNIREGDTRMGLDEQGTREIMEIMRREGVQFDQARLIRHNRILAQNGIDPSGMPLDAKAVTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0G8</accession>
    <name>W4K0G8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_453702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549495.1">
        <property type="nucleotide sequence ID" value="XM_009551200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0G8"/>
    <dbReference type="STRING" id="747525.W4K0G8"/>
    <dbReference type="GeneID" id="20676408"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_453702"/>
    <dbReference type="eggNOG" id="ENOG502S78W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013602_0_0_1"/>
    <dbReference type="InParanoid" id="W4K0G8"/>
    <dbReference type="OrthoDB" id="2507488at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="689" mass="75384" checksum="FC756866E0ABC241" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0I4</accession>
    <name>W4K0I4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_323280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549527.1">
        <property type="nucleotide sequence ID" value="XM_009551232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0I4"/>
    <dbReference type="STRING" id="747525.W4K0I4"/>
    <dbReference type="GeneID" id="20670952"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_323280"/>
    <dbReference type="eggNOG" id="ENOG502S5ZC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093919_0_0_1"/>
    <dbReference type="InParanoid" id="W4K0I4"/>
    <dbReference type="OrthoDB" id="5673at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="entry name" value="Chorismate lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="Chorismate lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="201" mass="22600" checksum="63BCB0BD3D955AF8" modified="2014-03-19" version="1">MAVIDSFKANTTSVDFQWPVEVTGLERIMLSAHGDLQRLLSAFFARTITIKTIYSHTSPRTHPASLEEPLTQRREVHLVCNRKTVCVATSTVTITTPHCERLFLDEKFAIGQMFRKVGKVPEFALLNCGLEDAEGDVQKLWRRYILAMDGFECDITEVFPDRDMFVRDSWIEEGITGDVGVEEGKQRYAAAQTSSHVSVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0X1</accession>
    <name>W4K0X1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial</fullName>
            <ecNumber evidence="11">1.14.15.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-methoxy-6-polyprenolphenol 4-hydroxylase</fullName>
            <ecNumber evidence="11">1.14.15.46</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">COQ6</name>
        <name evidence="13" type="ORF">HETIRDRAFT_478045</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-polyprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid. Also acts downstream of coq4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-polyprenyl)phenol to 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to coq6 from NADPH via a ferredoxin/ferredoxin reductase system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)phenol + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81183"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="EC" id="1.14.15.46"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81195"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="1.14.15.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.45" evidence="11"/>
    <dbReference type="EC" id="1.14.15.46" evidence="11"/>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549077.1">
        <property type="nucleotide sequence ID" value="XM_009550782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0X1"/>
    <dbReference type="FunCoup" id="W4K0X1">
        <property type="interactions" value="288"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K0X1"/>
    <dbReference type="GeneID" id="20677796"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_478045"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_8_0_1"/>
    <dbReference type="InParanoid" id="W4K0X1"/>
    <dbReference type="OrthoDB" id="683240at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120538">
        <property type="term" value="F:2-methoxy-6-polyprenolphenol 4-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106364">
        <property type="term" value="F:4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000021">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03193">
        <property type="entry name" value="COQ6_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000689">
        <property type="entry name" value="UbQ_mOase_COQ6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="3 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="38"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="422"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW78766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="594" mass="63737" checksum="C74D58877EB81EE7" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2B9</accession>
    <name>W4K2B9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_477569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548495.1">
        <property type="nucleotide sequence ID" value="XM_009550200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2B9"/>
    <dbReference type="STRING" id="747525.W4K2B9"/>
    <dbReference type="GeneID" id="20677753"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_477569"/>
    <dbReference type="eggNOG" id="ENOG502QSSK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164187_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2B9"/>
    <dbReference type="OrthoDB" id="21629at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="102" mass="12526" checksum="638E1761E669FE89" modified="2014-03-19" version="1">MMEQLAERRMQREEDEEDEDEEDEEEEEEVLTEEQKMEEGKKMFSIFAARMFEQRVLQAYLEKVAQERQLQLLREIEDEAKANKEREARKAKENQKKKDKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2L6</accession>
    <name>W4K2L6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_124275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548500.1">
        <property type="nucleotide sequence ID" value="XM_009550205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2L6"/>
    <dbReference type="GeneID" id="20666865"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_124275"/>
    <dbReference type="HOGENOM" id="CLU_2197320_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2L6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="108" mass="11607" checksum="93E2A2BA36DAC104" modified="2014-03-19" version="1">MSSNATDESTRFEPRFKARLRVRCSAYAAQVARLASTRGSSNLVTASSTPGSPQESARKVSADRSPQHAARIRIMLNKHTPFPPPSLAHTSAVPASIAPSPNPPHDYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2L7</accession>
    <name>W4K2L7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_453742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549541.1">
        <property type="nucleotide sequence ID" value="XM_009551246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2L7"/>
    <dbReference type="GeneID" id="20676411"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_453742"/>
    <dbReference type="HOGENOM" id="CLU_2210398_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2L7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="107" mass="11499" checksum="68D5B42FC63C8D3C" modified="2014-03-19" version="1">MSVAEPTHAPEVALMPESKILGPFAHYDIVPIDTASPSFQTSKAIYQKAKSKAVDHLGGVIPAHVLQTRSTPNPIDTPKTSWARSFSVMSQVQGPVPANSAVFECER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2Q5</accession>
    <name>W4K2Q5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_322010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548629.1">
        <property type="nucleotide sequence ID" value="XM_009550334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2Q5"/>
    <dbReference type="GeneID" id="20670806"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_322010"/>
    <dbReference type="HOGENOM" id="CLU_2391901_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2Q5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW80108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="94" mass="10781" checksum="B9628A8889C9DD53" modified="2014-03-19" version="1" fragment="single">WPGSDSINLDGVHRYIVRGDNESEVFNRVCFESALGGFQEQVIVQEYLHDLGRHASVFFDGFREYQNVIHIDCQDLCHNEVMENDVHHCLESGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2Y5</accession>
    <name>W4K2Y5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_419684</name>
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    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548618.1">
        <property type="nucleotide sequence ID" value="XM_009550323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2Y5"/>
    <dbReference type="GeneID" id="20673589"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_419684"/>
    <dbReference type="eggNOG" id="ENOG502RD14">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2838101_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2Y5"/>
    <dbReference type="OrthoDB" id="5401396at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW80094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="78" mass="8125" checksum="9941ED6F42DDF9FA" modified="2014-03-19" version="1">MHLFLQVYVTGFNSGQCVGVGSNFNDDVSSFGPDPGLVCTIYSDAGCVGRATGGIVYPGIDNLADYNNNDAMSSFSCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4K350</accession>
    <name>W4K350_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6987 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_451894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_451894"/>
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    <dbReference type="InParanoid" id="W4K350"/>
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    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1079"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW80248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1100" mass="119711" checksum="0350D341D375CF33" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3P5</accession>
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        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase II subunit RPB3</fullName>
        </recommendedName>
    </protein>
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        <name evidence="9" type="ORF">HETIRDRAFT_440329</name>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
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            <taxon>Heterobasidion annosum species complex</taxon>
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    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
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                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">TC 32-1</strain>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
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        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
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        <location>
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            <end position="276"/>
        </location>
    </feature>
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            <end position="323"/>
        </location>
    </feature>
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            <end position="397"/>
        </location>
    </feature>
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            <end position="323"/>
        </location>
    </feature>
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            <end position="367"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00072506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW80432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="397" mass="42170" checksum="A6C860CA4B4D4DC2" modified="2014-03-19" version="1" fragment="single">MQTNDILEPTVRIRDLQSDRVNFVLENADLALANSMRRVMMADIPTVAIDMVEIHANTTVLPDEFIAHRLGMIPLVSTNCDEAIRYNRDCTCARSCQNCSITLLLHVSCSDNRTMDITTNHLDVVAQFEDEEPAGEELSKRSKNFGEPVGKGGDNPVLIGKIRKGQELKVRCVAKKGIAKEHAKWSPCSAVSFEYDPHNRLRHTSYWYETDIKDEWPLSENAKEEEPPRDDELFDYNAKPNKFYMEVETDGSLGPQEVVMKGLADLQLKLANLILGLKSDSLPSVDQQLAPTQQNGTGTNGVPGGGWGASSSPGAGGWGGASGGGNGGAAGGWNAGGGAWGGSPAGGWAYGASGSPGSAPGPNSGQGPASGAGSWGSTSPQRTGWGSPQQQASGWNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3X4</accession>
    <name>W4K3X4_HETIT</name>
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        <submittedName>
            <fullName evidence="6">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_123066</name>
    </gene>
    <organism evidence="6 7">
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547267.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3X4"/>
    <dbReference type="STRING" id="747525.W4K3X4"/>
    <dbReference type="GeneID" id="20666804"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_123066"/>
    <dbReference type="eggNOG" id="KOG2563">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023132_2_0_1"/>
    <dbReference type="InParanoid" id="W4K3X4"/>
    <dbReference type="OrthoDB" id="422206at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER A3"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
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    </dbReference>
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        <location>
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    </feature>
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            <end position="443"/>
        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="467" mass="50480" checksum="EA1722C0D3CA84D0" modified="2014-03-19" version="1">MAPKQDADVVLQSDPDNVDNAIPGAAGAFRLYKRRWIGVFSLFVLEVVASMSWPWFGPISDSVVDQFGFTLDEVSWLGNIIACIYLPTSFLVPIITRRYGIRRCCQIGTVALLISAWVRYAGTVRSLSKHSAYALIIFGQLFSAIAQPVFQILGPKYSEVWFDLKGRTTATMILAISNPIGGAIGQLISPIVGDVRQSILVLGIVSTVVTPAVFLVFEKPPIPPTYAGSQKSPSIFLLINAAVGRPVPREAYMTPRERADFGILVFVFAVLLSAINTFSVMSSQWMAPYGYSDDTTGLMGATLLLVGIVAALASAPVFDRILTRHLGITIRLLCPIIGAGWFALIWAAKPKDTAGLFVIMAIIGAASIALLPVALELACELTRNADGSSAVLWFFGNLFSIIFLTSQSALRAPSTGSPPLNMHRAIIFNAVFTTFAVLLVFGLEGRQARRERDEMVVRGEVGEAGET</sequence>
</entry>
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    <name>W4K4J5_HETIT</name>
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        </submittedName>
    </protein>
    <gene>
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            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
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                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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            <begin position="1"/>
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        </location>
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        <location>
            <begin position="20"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79966.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="568" mass="60538" checksum="20C22FC8B1D1AAE6" modified="2014-03-19" version="1"> </sequence>
</entry>
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    <accession>W4K4T2</accession>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW80365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="51" mass="5973" checksum="466190D6B073C984" modified="2014-03-19" version="1">MSTLAQRFPLACLFTNPPCLLAVSLYRRSRTHCMHLTCIYLFGRFAPFFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4V8</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Asiegbu F."/>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
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                <person name="Karlsson M."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
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                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ETW80853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009549257.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="20665811"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_101940"/>
    <dbReference type="eggNOG" id="ENOG502SWH8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1510811_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW80853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="178" mass="18979" checksum="D48D1D74853546B5" modified="2014-03-19" version="1">MTDPQTSPSSATAPTHPLLAVNPSESASLKGHKAKTPIIAGVTTAGCLLLAWLVLLFLWLRKRCRRRRRIRAGLAPVPTRDDDDEDDERAPVRPKSTYIIPPDPAVLAGLRRPGEVVVGEPTVNGHRHGHGHGHGHDARPQAEGDGVAIDEGAIAGEEKHTGSRHSARGAFRAFASST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4K552</accession>
    <name>W4K552_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_321060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547568.1">
        <property type="nucleotide sequence ID" value="XM_009549273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K552"/>
    <dbReference type="GeneID" id="20670715"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_321060"/>
    <dbReference type="HOGENOM" id="CLU_050560_0_0_1"/>
    <dbReference type="InParanoid" id="W4K552"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="479" mass="52606" checksum="44D260C7D2CC327C" modified="2014-03-19" version="1">MLLHDDHDASSPSRNSSPDVVLMVANPDIERVERGTSPHRPDAGRIDRGTSPQQPGSTGVLLTPHLNNFSDDDAEDYGKFKERERTRRPSPERASRDAPRHENSDDRNQSSLGPLPVGVPPPSEGTRPSGVAGPSGLRARTAAQLPGHGEAESIPVLSETAPPPVPTSGPIPSSMGGPTPRTDPHTGELERHADALLQRNTISAVIQMATAMALQRLANFSAGQPGNEHSDVPRRLASASLQIRTLALQTDPDTASWYAHNDGRPRALLIHPDKFSQYVNRELLPALLFGGELGNVQPSRTDPFRVVTWNVPRPGEHPTPVSNPRRVPRTVVERPPPRQREVPTAHSHTATPPSHRIRGFPLSQGNTDEEEPPVYRRNEGRRSRGNQATLGRGTTAGRSIRHRPGSPPPSARFRTNEREDNRSSRRTRRADSEARRNSSWTRSELDAWDALDDPGNYDDADPYYRPDEGGGDYQGPFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4K564</accession>
    <name>W4K564_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_385524</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547579.1">
        <property type="nucleotide sequence ID" value="XM_009549284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K564"/>
    <dbReference type="FunCoup" id="W4K564">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K564"/>
    <dbReference type="GeneID" id="20672245"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_385524"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="InParanoid" id="W4K564"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000085">
        <property type="entry name" value="Dihydroflavonol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW80884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="347" mass="37685" checksum="395C1071837FCD76" modified="2014-03-19" version="1">MAPVSAPAKVLVTGANGYVAVWVTKALLESGYSVRGTVRSASKGEHLKKLFASYGDKLELVVVADITKEGAFDEAVKGVDLVEHTASPFHLKSKTPDEVIVPALKGTVSVLESIKKYGTSVKRVIVTASVASILQVPLLPNVFDESSWNEPSIKNCNELGDNANPMDMYCASKTLAEKAAWDFVEKNKGSISWDLVVLNPPYVYGATIQEVADTSSINTSMQEFYDRVILGNMDDDGLATNGNACVDIRDLAKAHVLAAQKAEAGGERIIISSAPYYWQEFVDISNAVAPTLKLHKGNPGSTKGKPYPCDFKNSKSARILGLKYIPKEDMIRDVLIDFKQRGWAQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5P8</accession>
    <name>W4K5P8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_419047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547803.1">
        <property type="nucleotide sequence ID" value="XM_009549508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5P8"/>
    <dbReference type="GeneID" id="20673522"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_419047"/>
    <dbReference type="HOGENOM" id="CLU_637872_0_0_1"/>
    <dbReference type="InParanoid" id="W4K5P8"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="380"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW81132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="430" mass="47632" checksum="E3DDD8F792100633" modified="2014-03-19" version="1">MQASQSDSTLASWNQTDFGSEQAFVNYGSEPYQSSSSDGLASFPYSIISSQNTEILNLVGCNPSRYSHYSPDEHEFYQMHGAYHHPGGVDFAATADMHYGNTSSHTDLSAAVDVCQDPILDPWAETTHERWKDAAHDAYPTIEPVQVREIVAPTPRHAVQMTLEAAPSSGRRPSVSALNPAFFGQHAWVKERRNRHSLASFYGESAYTENKYEHTSSLLEYEASEKHYQAQYQRRHDHQNAVMPWQGGAANTSANQCFSPCEHSQYYPYSSPSSIGVSPTSAPTASTSPHSQSPVAISILKSKFYIIPSEQYAPTIHTHTAYANHEAGILRGPNTGNQQGLTGRTSTESLETVCEEGSRTASVAQRRGRTRVVRNVQPIACFFCRGRKIACGPADPNSSDKTCMQCLKRHRKCVYPPESRRGRRQNEDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4K665</accession>
    <name>W4K665_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_104651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545938.1">
        <property type="nucleotide sequence ID" value="XM_009547643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K665"/>
    <dbReference type="GeneID" id="20666017"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_104651"/>
    <dbReference type="HOGENOM" id="CLU_1563071_0_0_1"/>
    <dbReference type="InParanoid" id="W4K665"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="171" mass="18126" checksum="5FAB347DDE10231D" modified="2014-03-19" version="1">MSEAAKRRPPIWLGPGTTTGSLGAPHAACMTAGRPRGGVHDEVEVMSTGKLDDDEDYDAAAIKQELGQYTPAPASASNEFSPTLYSVEEAKPAAPVQRASSSSASNRRVDRPEEDHYPLQPNLLRQQPPYSAESPSRRLPLSGRSSGDGRFRKASSECSSSAGCSPPPIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4K670</accession>
    <name>W4K670_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_439831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545956.1">
        <property type="nucleotide sequence ID" value="XM_009547661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K670"/>
    <dbReference type="STRING" id="747525.W4K670"/>
    <dbReference type="GeneID" id="20675196"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_439831"/>
    <dbReference type="eggNOG" id="ENOG502SG8H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1277755_0_0_1"/>
    <dbReference type="InParanoid" id="W4K670"/>
    <dbReference type="OrthoDB" id="4096268at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="23532" checksum="9671ACA2B7B30E4B" modified="2014-03-19" version="1">MDNAQLIRSIEQMFSNMNTQFTRQLATVQEKLTGQVEELRQDVAGIKVQVADLRQDVAGIKVQVADLQQDVAGLQQDVGGIKVQVADLQQDVAGIKVQVADLQQDVAGIKVQVADLQQDVAGIKVQVADLQQDVGGIKVHVADLQQDVGGIRGEVAGLRLDIAKLDETAQDNHAYTISKLSKVAQEVEDKVVVRMQDDVATLRMEVELFKGRVITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4K688</accession>
    <name>W4K688_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase/lipase/thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_51044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545830.1">
        <property type="nucleotide sequence ID" value="XM_009547535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K688"/>
    <dbReference type="STRING" id="747525.W4K688"/>
    <dbReference type="GeneID" id="20678167"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_51044"/>
    <dbReference type="eggNOG" id="ENOG502S3DF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129958_0_0_1"/>
    <dbReference type="InParanoid" id="W4K688"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF339">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="1">
        <location>
            <begin position="51"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="202" mass="22357" checksum="8CCB212A7AC2093D" modified="2014-03-19" version="1">MSPRTYVYKQVDGVDISFNLYLPILPSKPKHEFVQIQQISHHTVIHDVPVVVYFHGGGMTVGTRKSWFPIWLHLRLASAGVAFISADYRLMPPSNGHDIVSDIVVLFEFLRTSLNPRLQDETLLLRIDPTRIAVAGSSAGGLCAYLAAAHAAPKPIAVLSMYGLGGSFMVRHWTSSHFHTLHCLLNAPDATLPHTQTHTFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6N2</accession>
    <name>W4K6N2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_474814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_474814"/>
    <dbReference type="HOGENOM" id="CLU_656506_0_0_1"/>
    <dbReference type="InParanoid" id="W4K6N2"/>
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        <location>
            <begin position="1"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
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            <end position="276"/>
        </location>
    </feature>
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            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
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            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW81399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="419" mass="44668" checksum="5BAF4550E23B84A0" modified="2014-03-19" version="1" fragment="single">MSSVGVARSFWDVPEGPQGVSCRHNKARRPSHRPTALRLQPPPSSMDNDQRASAFLSLFSQDTQNSLHNLLFGAPNPSQPQGEGTSNAAAQPAPQQNVDTAAQRSATDLSSGSAGPDPAIYNSEAASSHDNSHPLDYHDSDTDVDIPPLISTATQPASHHTDMETDDDSDSMPDLQPISNVGEHSSAPLHDVHGQGDDDDIMPDLESVSGSSEYSDSSERDARDVEMNLGTHDGDHDSDWTDDDSDVSMDMPPLQPLPPPDRHVTIEEVQDPDDRPSGAVTGQGPSSSQPPRAQSSHTHPDPHHNHAHQQQHPPQGRTRRSFTFSSGQVPLPPLRAFFEPLFSNATMQGMANGNGNAPRFQVPTFQMPTGSNNTANPSGIPGNQPAEAGAQQQHGLPPPPPPRFDFSFFAATGPGAAMG</sequence>
</entry>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="2"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="112" mass="12569" checksum="1B0F5C0EDEBE49F2" modified="2014-03-19" version="1">MVKAIVNGTVIADSIDTIVVEGNHYFPPSDVKTVLFSDSNTSSVCAWKGPAQYYDASIEGKNIKDIAWYYPTPSAKATQIKSYIAFYKVRRSDLRGVVYLTPHYKNKVDIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4K715</accession>
    <name>W4K715_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="92"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="328" mass="35932" checksum="E06E43E8117C2096" modified="2014-03-19" version="1">MVHIKDLEMSISFYIDATSQPTVAFVREILPGHSSELKLEASGFSPLPAVWKDIKLAPQKTPAPTPSALSKNDAVSEPDKSPKSFKFSFPDGNVILLIEGTLYHLHHYLFIRHSSKSAAEFLQYTSDNDTLIKLDATDKQGFEALLSILYPLDFTRPNIEGVASWVSVLHIATEWGFKTIRELAIQSLAPIISPVDQVAREESLTFEEGRRLGLENVIAIDCARQEIRDQMAARSTAALTTTHCLACKASDIYTPPSPKVDPSAAQDPPSLVSFWTTRTSSMPTFTALPTPDSLKSSAGRVCGVQRGKLSPTEISRQVARSIPQLVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
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    <name>W4K799_HETIT</name>
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        <recommendedName>
            <fullName evidence="6">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546264.1">
        <property type="nucleotide sequence ID" value="XM_009547969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K799"/>
    <dbReference type="FunCoup" id="W4K799">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K799"/>
    <dbReference type="GeneID" id="20672181"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_384000"/>
    <dbReference type="eggNOG" id="KOG0379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005349_2_1_1"/>
    <dbReference type="InParanoid" id="W4K799"/>
    <dbReference type="OrthoDB" id="10001928at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF2">
        <property type="entry name" value="NEGATIVE REGULATOR OF SPORULATION MDS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="208"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="475"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="597"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW81634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="699" mass="77936" checksum="CC1482E74D4B3D06" modified="2014-03-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9K1</accession>
    <name>W4K9K1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_475234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC123 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546361.1">
        <property type="nucleotide sequence ID" value="XM_009548066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9K1"/>
    <dbReference type="FunCoup" id="W4K9K1">
        <property type="interactions" value="546"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K9K1"/>
    <dbReference type="GeneID" id="20677615"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_475234"/>
    <dbReference type="eggNOG" id="KOG2983">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034402_2_0_1"/>
    <dbReference type="InParanoid" id="W4K9K1"/>
    <dbReference type="OrthoDB" id="360540at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009772">
        <property type="entry name" value="CDC123"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323:SF6">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 123 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323">
        <property type="entry name" value="D123 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07065">
        <property type="entry name" value="D123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW81751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="369" mass="41958" checksum="A02C2CF46AE05F3E" modified="2014-03-19" version="1">MSTSSNTLFPPLSHSDILAFQFSAWYPTFSGLSIKSTVIRPLGADFRDYLDADSVFVPKGSEDVPARSTLEDEADEDEGNEDEDDRQEFAFPELDARIREAVREYGAVFPKLNFSSPKDASWLLPSSSPLKCTAPADVYILLKSSDFITHDLSMDIVFEGCEETSLDAVTTGRAQETPYELELVLRKWYAIDRSREIRCFVRNGALIGLSQRDTNFYDFLAETGTQTTIVTSVRTYWETHVKSKWTGPDSYVFDVLLTRDLTRFHILDFNPYAPRTDPLLFTYEELCDISTHIRDSDEIIPHLRVIDSPAHPVATRNTPAHQHNMVPFEALSLSEGRDVDSFRKIWEDEIKKGMDESDDEDYDKGSLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KA30</accession>
    <name>W4KA30_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Potassium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_168843</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546752.1">
        <property type="nucleotide sequence ID" value="XM_009548457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KA30"/>
    <dbReference type="FunCoup" id="W4KA30">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KA30"/>
    <dbReference type="GeneID" id="20668186"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_168843"/>
    <dbReference type="eggNOG" id="KOG1341">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005947_3_0_1"/>
    <dbReference type="InParanoid" id="W4KA30"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004773">
        <property type="entry name" value="K/Na_transp_Trk1/HKT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00934">
        <property type="entry name" value="2a38euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="440"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="542"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="571"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW82205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="671" mass="75838" checksum="7B17622126C9A5DB" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAB4</accession>
    <name>W4KAB4_HETIT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_433609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545058.1">
        <property type="nucleotide sequence ID" value="XM_009546763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAB4"/>
    <dbReference type="GeneID" id="20674683"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_433609"/>
    <dbReference type="HOGENOM" id="CLU_2171403_0_0_1"/>
    <dbReference type="InParanoid" id="W4KAB4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="110" mass="11559" checksum="1C8869EC6EFD896D" modified="2014-03-19" version="1">MQPKSTHPRSGANSTSQINASLPVTTEQNRRCAHSASSAESCRTASISDLEVKGGHEKGSADVDARDERAQMGDRSREAVKPCPANDHEGCHPSSPSALTHGIARVAPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAX3</accession>
    <name>W4KAX3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_426408</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545240.1">
        <property type="nucleotide sequence ID" value="XM_009546945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAX3"/>
    <dbReference type="FunCoup" id="W4KAX3">
        <property type="interactions" value="469"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KAX3"/>
    <dbReference type="GeneID" id="20674116"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_426408"/>
    <dbReference type="eggNOG" id="KOG2808">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039675_0_0_1"/>
    <dbReference type="InParanoid" id="W4KAX3"/>
    <dbReference type="OrthoDB" id="10261918at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000002">
        <property type="entry name" value="Pre-mRNA processing factor 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="9">
        <location>
            <begin position="100"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW82938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="355" mass="40088" checksum="5A8F9A8EE64CD05F" modified="2014-03-19" version="1">MDALKAAIQTKRKALDEMPSKPSKYMRRGDIERLKEEEERKAREAERLAKEEAERNTPKAKTPASRSQTSSPHPSASRLTASPPPDASTLEAITTTFNISNDETVRRLRAKGQPVRLFGESDKERRLRLRALELIEEKGHDRAGGQNDFRKALEDVESAERELKDRTSASDAGKGKKKGDAEGEGGVLDLGLIKTDPDKLYPIIYFALKRTLKEWEESLAERPEHIKRSTQGKLAAATQVQSAEYLKPLFKIIRSRSLPSDVLARIAEIVHHMQKRQYQRANDSYLRLSIGNAPWPIGVTMVGIHERSAREKISSDQVAHVLNDEVSRKYIQSLKRLLTFSQTKYPPEDVSQLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4KB01</accession>
    <name>W4KB01_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_450713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545303.1">
        <property type="nucleotide sequence ID" value="XM_009547008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KB01"/>
    <dbReference type="GeneID" id="20676072"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_450713"/>
    <dbReference type="HOGENOM" id="CLU_1434607_0_0_1"/>
    <dbReference type="InParanoid" id="W4KB01"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW83012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="189" mass="20410" checksum="3F3E2ED967233C3C" modified="2014-03-19" version="1">MLSSHNLPERPRPFNCACSSSLHLEPYTQGLVELLRIFHLLSIPQLTPSTPDLRSAPLVRNPQTTVLDIDAPDSSPSFCDVDRDIASSLSASTASSASSPHSAEEGAFWLCISTKFSSSSNSSVMLPRSPLIPSVPSGLGITLGERTPPDLALKPLRTVAHPVTNTGSHALYRQWTSERAWIGARRALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KB37</accession>
    <name>W4KB37_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_417056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545337.1">
        <property type="nucleotide sequence ID" value="XM_009547042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KB37"/>
    <dbReference type="GeneID" id="20673380"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_417056"/>
    <dbReference type="HOGENOM" id="CLU_2527726_0_0_1"/>
    <dbReference type="InParanoid" id="W4KB37"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="84" mass="9512" checksum="FE3DE93471E8D48B" modified="2014-03-19" version="1">MASHRVLLVLTLWNFILLGACHPIQLDVKYRIAQYREVKLIGVLSYLLLVLGAFSVELSHADTFSGPPGLYVQPLVTHPWKTPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBE2</accession>
    <name>W4KBE2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_416575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544736.1">
        <property type="nucleotide sequence ID" value="XM_009546441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBE2"/>
    <dbReference type="STRING" id="747525.W4KBE2"/>
    <dbReference type="GeneID" id="20673335"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_416575"/>
    <dbReference type="HOGENOM" id="CLU_871710_0_0_1"/>
    <dbReference type="InParanoid" id="W4KBE2"/>
    <dbReference type="OrthoDB" id="73076at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="319" mass="35621" checksum="001955916DEDE9DE" modified="2014-03-19" version="1">MDDKICPLLPWMHSSKVCKHVFAECRKLVKDFAFTDLIQMMPRLHVSIRAIVLLDVMTDPKARASGYAHTYFNSHGINLGVLACFPTDSEIQSATKDAWEEAENLFNILGVSPSDFLLASHPTLPSINSWYVPGMGPMADKAGSDTDSSEDEQDKGDDEVGDTDELRQLLVDIRRSGFHEHSVDERLLNLQCATVAMDIDDLVQLKDMAHKLSQEEQEANLENDQSNILAVLHAAQLPPVNLPPEPRHAFDVHFSSVDTLDFSLLIEIQQAHKTHRAAHGVRELAVPESTPSQSKKLGKESLQRQIIQEMQALLSQQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBH2</accession>
    <name>W4KBH2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_315517</name>
        <name evidence="1" type="ORF">HETIRDRAFT_331369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544771.1">
        <property type="nucleotide sequence ID" value="XM_009546476.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553002.1">
        <property type="nucleotide sequence ID" value="XM_009554707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBH2"/>
    <dbReference type="GeneID" id="20670231"/>
    <dbReference type="GeneID" id="20671653"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_315517"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_331369"/>
    <dbReference type="HOGENOM" id="CLU_1156517_0_0_1"/>
    <dbReference type="OrthoDB" id="3070096at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW75606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="240" mass="27258" checksum="8C488170B52DAD04" modified="2014-03-19" version="1">MQTELPRIMQTVPVPHSGHMAAPPPLTLIPSSSPPNTRSVPFHPKITSFAPTPLTPTGIQVLMTTGQKREEQEQRYRDLADTIAAAFNTLRDTHIACFVRGVEDWQEHSMTRCKHGVCSLGDSDWQQWQANALRLSEGWCYKCCVPQKSTGGWHSYVKKDMVCPDANLIKAAIYVLWTYPPTDFKLTDCEFVIPECLGSLNAFQDWLLEAPRDMDIPPKTGFNNMLRLFVWLLERRQISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBQ5</accession>
    <name>W4KBQ5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_426159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="STRING" id="747525.W4KBQ5"/>
    <dbReference type="GeneID" id="20674085"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_426159"/>
    <dbReference type="eggNOG" id="KOG0351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_304619_0_0_1"/>
    <dbReference type="InParanoid" id="W4KBQ5"/>
    <dbReference type="OrthoDB" id="3202072at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="OrsD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12013">
        <property type="entry name" value="OrsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="951"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="957"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="975" mass="111312" checksum="F81B4CF259EB8C18" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCB1</accession>
    <name>W4KCB1_HETIT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_54372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544637.1">
        <property type="nucleotide sequence ID" value="XM_009546342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCB1"/>
    <dbReference type="STRING" id="747525.W4KCB1"/>
    <dbReference type="GeneID" id="20678299"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_54372"/>
    <dbReference type="eggNOG" id="ENOG502SKHB">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002498_2_0_1"/>
    <dbReference type="InParanoid" id="W4KCB1"/>
    <dbReference type="OrthoDB" id="3208495at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="481" mass="54368" checksum="B124A42A8C22B89C" modified="2014-03-19" version="1">MTPASLESQPTLATLPLPEEAVLSSTQPFTNRSSELLLGWHYSGSNLKSGGEFDRLVQTLLHPDFNLKELPGVSFARETKRLDKHIANPDNPLQGQDGWHHASVDIRLPPVDKQTVKPENESPIFTVSGVFHRRLVDIIRATYASPISCSFHMTPFRQFWCPTPDALPIALYSEIYSSTTMIEAHLEISGMPRIGPDDTHERVVAPLMVWSDSTHLANFGSASLWPFYLQFGSQSKYTRGKPTSHSAHHLAYIPTIPDKIQEAYMKVFGKAATSAMLRHCKRDLMHAIWLLLLDADFMEAYEHGMLINCGDGIVRRIFPRFFTYSADYPEKVLLAGIRSLAKCLCPRCMVEKTQVYKMGSKLDMRLRTKTARVDNAQRRHTVEIARKIIYEQGYGIESMAVDALLANKSWVPTRNAFSSKLSKFGFNFYDLFVVDLLHEFELGVWKAIFTHLLRILWAAGGDKIQELNSRQVLTGPERIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCD2</accession>
    <name>W4KCD2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_312498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543311.1">
        <property type="nucleotide sequence ID" value="XM_009545016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCD2"/>
    <dbReference type="STRING" id="747525.W4KCD2"/>
    <dbReference type="GeneID" id="20669959"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_312498"/>
    <dbReference type="eggNOG" id="KOG3872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1482163_0_0_1"/>
    <dbReference type="InParanoid" id="W4KCD2"/>
    <dbReference type="OrthoDB" id="3068102at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="182" mass="19786" checksum="72E4498A7F418B75" modified="2014-03-19" version="1">MGDNMRAPGKGSRSFDYVLTRLQGGLHKSRETGAELNSLSGAMNEIHETLSGVPPSNLPPYPQTIPPVQPPQPPPPTEPPTSESSAPTPATVVELQSQMQESQVSLASFVDKICIMEGMLSEHEAINREVSTLHELMEEEKRELDSARCRRRSGTLRAEDHDGGKYGGDDDDAQSITTVTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCR9</accession>
    <name>W4KCR9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_449278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543356.1">
        <property type="nucleotide sequence ID" value="XM_009545061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCR9"/>
    <dbReference type="STRING" id="747525.W4KCR9"/>
    <dbReference type="GeneID" id="20675931"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_449278"/>
    <dbReference type="HOGENOM" id="CLU_744062_0_0_1"/>
    <dbReference type="InParanoid" id="W4KCR9"/>
    <dbReference type="OrthoDB" id="107110at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="372" mass="41685" checksum="EEB5BB6F5CEA2BBF" modified="2014-03-19" version="1">MSSGQVSGAIFTLFLSKRAHPQQSILMEGEQNNESVSPRSIDPYTDLGFDQFAKIINWGDTWTLEEVATDDHLATLGRPLLPLEFISNMYESLEQQQQIEGHMRVPLKIESGFRTMETICPSEPILAEGPTPDDAQKSRGARKDVLLEDILSAGPYVFKSDEEKDRPLKETFAKIHDRSLLRREYLLYLASRGIGTLYATSQAGIDAFVPFNDHRYATTINPSLLDDMDPYDLGLFNEEGDANVPIIRIVFALAGRTTFLTARSPLSPSTRKEKSEALKRSAPSAPDTSLTIGPMLTGPYQPPTSESLDQEAKESRRFTAYDIWCSGLTSEIYAPITQESESVWADSLKTSKRWKEPMYETGDETNDRLRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCV2</accession>
    <name>W4KCV2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine protease S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_315128</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545447.1">
        <property type="nucleotide sequence ID" value="XM_009547152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCV2"/>
    <dbReference type="STRING" id="747525.W4KCV2"/>
    <dbReference type="GeneID" id="20670190"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_315128"/>
    <dbReference type="eggNOG" id="KOG1153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_1_1_1"/>
    <dbReference type="InParanoid" id="W4KCV2"/>
    <dbReference type="OrthoDB" id="19448at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844160" evidence="6">
        <location>
            <begin position="20"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="8">
        <location>
            <begin position="37"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="7">
        <location>
            <begin position="166"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW83165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="391" mass="39371" checksum="0AAA835855540624" modified="2014-03-19" version="1">MIFSALFVSLALLVSSVLGAPNRLLSVERYDGETSGRYIVTLKADTVKSDHLSWVNEAAGAGANITHDWNPDFVNGYAANLDDNALRTLRASPDVESIGEDGVVSIKVTETNAPWGIARLSSTSAISGSDTANSYTYTYNSAAGSGVDIYVIGEPAALSDFGGRARWGATFGGYADADGNGHGTHVSGTAAGTRWGVAKAANLIAVKVLSDSGSGSVSDIVSGLDWVATQVSSSGRPSIATLSLGGSASTALDNAVTSLVNQGIHVTVAAGNSNTDASSSSPARATAVNTIGATTIADARASYSNYGSVVDIFAPGTDVTSSWIGSTTATNTISGTSMATPHVAGLLAYLISVNGNSSPASLTSTLKGLGLSGVLTGIPSGTVNLLAHNDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4KD63</accession>
    <name>W4KD63_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_314444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543490.1">
        <property type="nucleotide sequence ID" value="XM_009545195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KD63"/>
    <dbReference type="STRING" id="747525.W4KD63"/>
    <dbReference type="GeneID" id="20670123"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_314444"/>
    <dbReference type="eggNOG" id="KOG1337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048453_0_0_1"/>
    <dbReference type="InParanoid" id="W4KD63"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF147">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW83733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="49950" checksum="493FEB27741320FC" modified="2014-03-19" version="1">MPVDSLQHAVTTESKHIIEFKTWMTANGAYLDPHVRYAPVDTGHTVITIDALEPETTIVTCPFSLVITPNLSRTALLTLLQNETIISNWSERQLICAYICFHWILEPERYDALAHAPYLRTLPPLERLRTPLHFTSAELDALKGTNLYGATLDRRNEWEKEWSRCQTSISQANRSWADSFTWDRYLTAATYLSSRAFPSTLLAPAPSLVTGPSSYPVLLPGVDALNHARAHPISWVVSFTPSDGKEHNQKKEAAQASSALSSRLSAVNGEDASISLVNPAPIPALSELFNNYGPKPNSELILGYGFSICDNPDDTIVLRIGGATAEGKKWEVGRDARGVEGVWDEILHAVRAAAQAEGEEGDIPTWSLTHDAAATLQSMSSALLLRLPGPPQAEIRSDVAEMIKDYVTGQREILLDLVRFAEEKEAEAIMEAKREGVKFLEGVDEEEETQEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDV9</accession>
    <name>W4KDV9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_314219</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009545420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDV9"/>
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        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KDV9"/>
    <dbReference type="GeneID" id="20670105"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_314219"/>
    <dbReference type="eggNOG" id="KOG0724">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037236_0_1_1"/>
    <dbReference type="InParanoid" id="W4KDV9"/>
    <dbReference type="OrthoDB" id="413400at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DnaJ_domain"/>
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    <dbReference type="InterPro" id="IPR052606">
        <property type="entry name" value="DnaJ_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="44"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="266"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW83993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="330" mass="36421" checksum="EC414AEDE71F179F" modified="2014-03-19" version="1">MDKSELLSRVERIVTLTTVCRAKEDHEIFDLVSSLEAAEGKGTTFYSWLDVSPTATTPEIARAYRKKSIQLHPDKNPGVKGIHDRFARLGVVSTILRNEEGRKRYDFFYKNGVPRWRGTGYYYSRFRPGLGTVFVFLVTVTSAFHYIALRLNYARDVARVEFIIREAKTAAWGQKLSPIEGRRKVKVNLGGGARYDDEGNVIPGRMIDMVVEGNGDVFMYESDGSLHPVGAHMATPASVRSTWFIALMTSQFAKVYGRVTGQNTAHVQDEDAETEDGVSATGTDSDLPELEYPEQANGKGKGSSSAAVAASGKEAAVKAGGKRRKAVKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEF7</accession>
    <name>W4KEF7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidylethanolamine binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_170160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543465.1">
        <property type="nucleotide sequence ID" value="XM_009545170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEF7"/>
    <dbReference type="STRING" id="747525.W4KEF7"/>
    <dbReference type="GeneID" id="20668267"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_170160"/>
    <dbReference type="eggNOG" id="KOG3346">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_043994_1_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844431" evidence="1">
        <location>
            <begin position="19"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="292" mass="30970" checksum="538B098C2BE4D59A" modified="2014-03-19" version="1">MFVFVVALHLLFALRGAARRDRDDHDPSDPIDVTIPVVEQAFDNARIVPDVLLSFTPTSILDVDFIDPDSSKLELHSVTPGIQLSMEQTLLAPRFSLSTNDTSIVNEKFVIALVDPDAPTPQNRSLSQFRHFLGGDFHLDGSSTIRAPLVNSSAALTEYVNPTPPIGYVILLFVQPTNFDTVAPNFVTPSTPRPNFDLATFVEEAGLGAPIAGTFFLTRADVDGGTSSGGVGAPATATATNTVVIASSPSAGGRSVPTSLGSTSGANASFMKGIRGEFRRACLVFVASLFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEI9</accession>
    <name>W4KEI9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Metallo peptidase M43B, zinc-dependent metalloprotease, pappalysin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_62980</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M43B family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543283.1">
        <property type="nucleotide sequence ID" value="XM_009544988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEI9"/>
    <dbReference type="MEROPS" id="M43.008"/>
    <dbReference type="GeneID" id="20678625"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_62980"/>
    <dbReference type="eggNOG" id="ENOG502RYKG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048726_1_1_1"/>
    <dbReference type="InParanoid" id="W4KEI9"/>
    <dbReference type="OrthoDB" id="536211at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04275">
        <property type="entry name" value="ZnMc_pappalysin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008754">
        <property type="entry name" value="Peptidase_M43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466:SF1">
        <property type="entry name" value="METALLOPROTEASE MEP1 (AFU_ORTHOLOGUE AFUA_1G07730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05572">
        <property type="entry name" value="Peptidase_M43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844245" evidence="10">
        <location>
            <begin position="19"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M43 pregnancy-associated plasma-A" evidence="11">
        <location>
            <begin position="189"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW84262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="287" mass="29770" checksum="2E77FC99E03C34CC" modified="2014-03-19" version="1">MLFSSAVAFLLGSTFALAGPLASNKTITRCGTFISDEALIAAEAHFAKHKVVSSLSANAASFSIPVYFHVVSEDSTASGGNIPDSQITSQISTLNSDYSGSGLTFSLAATTRTVNSDWFNNAGPDSSQQDAMKKALRKGGATALNLYSVGFTSGTGEGLLGYSTFPSDYSSAPTDDGVVFLFSSVPGGSTTNYNEGKTVTHEVGHWVGLYHTFQGGCSGSGDSVSDTPAEASAASGCPTGRDTCSSSGVDPIHNYMDYSYDSCMNQFTAGQITRLQGQISTYRGISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KES9</accession>
    <name>W4KES9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_381701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543939.1">
        <property type="nucleotide sequence ID" value="XM_009545644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KES9"/>
    <dbReference type="GeneID" id="20672083"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_381701"/>
    <dbReference type="eggNOG" id="ENOG502SS0U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112530_0_0_1"/>
    <dbReference type="InParanoid" id="W4KES9"/>
    <dbReference type="OrthoDB" id="3259878at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="162" mass="18029" checksum="3752056042ECF136" modified="2014-03-19" version="1">MAPHSPRRHRLPQHRDFILIPKPLDLSLSDVSEKSPLPAIIVTPSSPSSSGDFSIAFLAPPKASLRERVTSFTAPKQLKARTTLILLLLFFILACHLLTHRLATHNPHLEFNTMNDVSFHTDAEQTPVSTASLFASWFDWKLLGLSVPDGKREFVVTEPVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4KG53</accession>
    <name>W4KG53_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_473550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544461.1">
        <property type="nucleotide sequence ID" value="XM_009546166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KG53"/>
    <dbReference type="GeneID" id="20677524"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_473550"/>
    <dbReference type="HOGENOM" id="CLU_1938438_0_0_1"/>
    <dbReference type="InParanoid" id="W4KG53"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="15402" checksum="CB9B86A2B5DAD084" modified="2014-03-19" version="1">MPADDQDEADEPQDEEDHDEGQHQLGDETSLSKREAVVVIDEKIYGRDPLRCLACNNKSFARKYERRRHVVTVHYLKKVSCDWCGIFFYTRRDGVTRHKDENCPARDFEDRHTNPMRWFMAWLSGPSGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGH3</accession>
    <name>W4KGH3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_165815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544563.1">
        <property type="nucleotide sequence ID" value="XM_009546268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGH3"/>
    <dbReference type="FunCoup" id="W4KGH3">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KGH3"/>
    <dbReference type="GeneID" id="20668013"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_165815"/>
    <dbReference type="eggNOG" id="KOG1472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086729_0_0_1"/>
    <dbReference type="InParanoid" id="W4KGH3"/>
    <dbReference type="OrthoDB" id="1937912at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="198"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW84942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="280" mass="30901" checksum="0A4946E64D20D2C5" modified="2014-03-19" version="1">MYHFTAPSSTDKLPPSSVSSQLDEELLQPPAKRRRISSSSLSDAEDDEDENRPFASRMVGTHVSSNGTRPHGRRSGKKASSMKSKAQTASASIPPPTGEQQAEMNGEFLQLNGHEPPVKMEDQLDEGQLDLLATGVTVDTASAATISPPLKPEKISAKELRKGVIKILPIENDGQPRSFVILTNLKTLFQKQLPAMPREYIARLVYDSNSKCLAICKRGYKVVGGICYRPLPHRGFAEIVFFATASADQVKGYGALLMDHFKAHIRRTYPRHDAFSDIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGH7</accession>
    <name>W4KGH7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_146885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544085.1">
        <property type="nucleotide sequence ID" value="XM_009545790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGH7"/>
    <dbReference type="GeneID" id="20667168"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_146885"/>
    <dbReference type="HOGENOM" id="CLU_1310284_0_0_1"/>
    <dbReference type="InParanoid" id="W4KGH7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="210" mass="22860" checksum="BB71810477E9F874" modified="2014-03-19" version="1">MRMERTDETDEWTERNGQEKRTKRKEQTRTTSQLTHTKHRTKTPPGATASSRQRTHPQGHKAARYPRQSSNPNRSTENAAKSSRDGYLSASARGNPISIELERQWPPPGRVRADGRITSMNGIAAPPAFVVAFVAVGPVGRPHGAAPSPSQSVSESESVVDAAELAEVVSRRSARSPPRCRSAIRLTAAIRLALAAVDDDDDDDDDDDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGI7</accession>
    <name>W4KGI7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_473537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544443.1">
        <property type="nucleotide sequence ID" value="XM_009546148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGI7"/>
    <dbReference type="GeneID" id="20677523"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_473537"/>
    <dbReference type="HOGENOM" id="CLU_2386432_0_0_1"/>
    <dbReference type="InParanoid" id="W4KGI7"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW84814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="94" mass="11366" checksum="951B18E5C43D4C2C" modified="2014-03-19" version="1">MRCVPCNKTFRRKYDRRRHVVTVHYLGKIPCDWCDLFFYARRDGVTRHKDENCPARDFEDRHTNPRRWFMAWLTGPCRSSRRRRGRAGSSTMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGM6</accession>
    <name>W4KGM6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_48054</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543228.1">
        <property type="nucleotide sequence ID" value="XM_009544933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGM6"/>
    <dbReference type="STRING" id="747525.W4KGM6"/>
    <dbReference type="GeneID" id="20677919"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_48054"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_1"/>
    <dbReference type="InParanoid" id="W4KGM6"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034040">
        <property type="term" value="F:ATPase-coupled lipid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03228">
        <property type="entry name" value="ABCC_MRP_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF646">
        <property type="entry name" value="HAEMOLYSIN SECRETION ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="448"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW84465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="721" mass="80328" checksum="446B918F4EABB5DA" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHV6</accession>
    <name>W4KHV6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_311634</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544519.1">
        <property type="nucleotide sequence ID" value="XM_009546224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHV6"/>
    <dbReference type="STRING" id="747525.W4KHV6"/>
    <dbReference type="GeneID" id="20669888"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_311634"/>
    <dbReference type="eggNOG" id="KOG1209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="InParanoid" id="W4KHV6"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW84895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="26704" checksum="74799A14A90022B5" modified="2014-03-19" version="1" fragment="single">CTTGRIGEALAKEFHSQGNAQVFATSRNVDAMPTLAAIGIETLALDVTDVNSIREAKNVIAERTGSSLDILVNNAGTTYPSAASDISMDRVRAVFDVNLFGAMTAVHEFLPLLLATGDSRIVQMSSLAGLMPVPFNSAYNTSKAALLSYGDTLRVELAPLNSIMQNMPRSLPPDSIYQPINQEYARDRIEHFQDSALPVSQLAKTVVAEALTKTPRAWVYTSKNAWLVWIVSTFMSRTGFVRVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIM4</accession>
    <name>W4KIM4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Complex I-B15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_379576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542406.1">
        <property type="nucleotide sequence ID" value="XM_009544111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIM4"/>
    <dbReference type="STRING" id="747525.W4KIM4"/>
    <dbReference type="GeneID" id="20671974"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_379576"/>
    <dbReference type="eggNOG" id="ENOG502S8RT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_183941_0_1_1"/>
    <dbReference type="InParanoid" id="W4KIM4"/>
    <dbReference type="OrthoDB" id="15108at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39476:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39476">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE 6.6KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9569" checksum="7A0FC2699714379A" modified="2014-03-19" version="1">MAGHGYVRTDASVERWNRMREDVYKHFRFTSKASWISLTGLLFIPAGMVWFSAQQDLKWSFSGKRKGESLYRIAPPAAEPTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIX2</accession>
    <name>W4KIX2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_457489</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542601.1">
        <property type="nucleotide sequence ID" value="XM_009544306.1"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KIX2"/>
    <dbReference type="GeneID" id="20676838"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_457489"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_82_0_1"/>
    <dbReference type="InParanoid" id="W4KIX2"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000595">
        <property type="entry name" value="Protein kinase, putative (AFU_orthologue AFUA_5G11840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF137">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="ETW85777.1"/>
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        <source>
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    <sequence length="1289" mass="137481" checksum="391D5D41D15EA2B0" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
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    <name>W4KJG7_HETIT</name>
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        <recommendedName>
            <fullName evidence="9">Histidine kinase/HSP90-like ATPase domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="10" type="ORF">HETIRDRAFT_311260</name>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10 11">TC 32-1</strain>
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        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW85997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="701" mass="79706" checksum="EB7B922FAF7F60E5" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJK4</accession>
    <name>W4KJK4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Non-catalytic module family EXPN protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_60450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="747525.W4KJK4"/>
    <dbReference type="GeneID" id="20678513"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_60450"/>
    <dbReference type="eggNOG" id="ENOG502S3R6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046371_0_0_1"/>
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    <dbReference type="OrthoDB" id="406505at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
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    </dbReference>
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        <property type="entry name" value="RlpA-like domain"/>
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    </dbReference>
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        <property type="entry name" value="Expansin/allergen_DPBB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF24">
        <property type="entry name" value="RLPA-LIKE PROTEIN DOUBLE-PSI BETA-BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50842">
        <property type="entry name" value="EXPANSIN_EG45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <begin position="93"/>
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        </location>
    </feature>
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        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
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        <location>
            <begin position="120"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW85874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="337" mass="34305" checksum="C5BB6257881A7AA1" modified="2014-03-19" version="1">MFNLLPLASVALFAASSVNAIVVPRRDPPAGWATNYLEDYTTYHVRYLALDCQDKHNTDFFDQCCHPLLATETLQTARASQCIPSAAASVSASAAEPSSTVATPADDDCDDDDEPVSSAAAPTSQVAVATSQVAIVSTSPSPSPTPKSTKVKDSSTKAEAPASSPAPTTSATPVTSAMPVTSAAPVTSAALVTSATPESTSKKPASSSAKPSKTSSSAPAATSASSISDSVGQILSGGFATFFYQGGVAGACGVVHSDNDLIAAIDQDRYGDSGEKSDLCGKQVKITNTNNQKSVTVTIVDDCPTCVSSNSIDLSVGAFTAIATEDEGMVPITWSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJV9</accession>
    <name>W4KJV9_HETIT</name>
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        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_443702</name>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IST1 family.</text>
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        <property type="protein sequence ID" value="ETW85989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="747525.W4KJV9"/>
    <dbReference type="GeneID" id="20675538"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_443702"/>
    <dbReference type="eggNOG" id="KOG2027">
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    </dbReference>
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    </dbReference>
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    <dbReference type="InParanoid" id="W4KJV9"/>
    <dbReference type="OrthoDB" id="29853at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Vacuolar protein sorting-associated protein Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR042277">
        <property type="entry name" value="IST1-like"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161">
        <property type="entry name" value="IST1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161:SF5">
        <property type="entry name" value="IST1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03398">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="214"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="703"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="775"/>
            <end position="1310"/>
        </location>
    </feature>
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        <location>
            <begin position="663"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="707"/>
            <end position="726"/>
        </location>
    </feature>
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        <location>
            <begin position="775"/>
            <end position="806"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="966"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
            <begin position="1103"/>
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        </location>
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    </feature>
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        <location>
            <begin position="1285"/>
            <end position="1295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW85989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1310" mass="142969" checksum="9A9FDF28B9F21B70" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLQ5</accession>
    <name>W4KLQ5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_241958</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540756.1">
        <property type="nucleotide sequence ID" value="XM_009542461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLQ5"/>
    <dbReference type="STRING" id="747525.W4KLQ5"/>
    <dbReference type="GeneID" id="20668912"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_241958"/>
    <dbReference type="eggNOG" id="KOG0603">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1622905_0_0_1"/>
    <dbReference type="InParanoid" id="W4KLQ5"/>
    <dbReference type="OrthoDB" id="193860at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW86768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="164" mass="18560" checksum="A9CDB57D525D1F61" modified="2014-03-19" version="1" fragment="single">QYVFQEQRIMQEITTQSSGNFATRLLASFQDEYNLYLVMRYYPLDLWGLVCSMPVDFTLEAIQFYAAELILGIEQLHNLGIIHGDLKAANVLVTPTGHLALTDFNLSFRVQLGNQEALRDAQMRGYMVGTIGYLAPEVLKWSENGVNYTGQVDLWAYGIILGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLU9</accession>
    <name>W4KLU9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_447381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540692.1">
        <property type="nucleotide sequence ID" value="XM_009542397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLU9"/>
    <dbReference type="GeneID" id="20675771"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_447381"/>
    <dbReference type="HOGENOM" id="CLU_1349081_0_0_1"/>
    <dbReference type="InParanoid" id="W4KLU9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="203" mass="22371" checksum="7E6D7470E65294D9" modified="2014-03-19" version="1">MSLPPRSFPNVSSPHPAPAFGCIYTPRSLSSTSSNSLPAALIPAFMMRRPPAGVDHAWASPSRGPILCCPSPAVLSIFTFAFSLWLHIILDARKESKRHSLATILRIASGMPTAYGLRSDLPPLPKFFASPSRQSLTGSAHAPMLSTQWAYLCPYPSERPSVRTRPSVHADLRRFRIWNLFLLLVASRSSEPFISALHFNTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4KM30</accession>
    <name>W4KM30_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cerato-platanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CerPla2</name>
        <name evidence="6" type="ORF">HETIRDRAFT_145203</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cerato-platanin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540838.1">
        <property type="nucleotide sequence ID" value="XM_009542543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KM30"/>
    <dbReference type="GeneID" id="20667069"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_145203"/>
    <dbReference type="eggNOG" id="ENOG502SQTH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1096461_0_0_1"/>
    <dbReference type="InParanoid" id="W4KM30"/>
    <dbReference type="OrthoDB" id="4898945at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22778">
        <property type="entry name" value="DPBB_CEPL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010829">
        <property type="entry name" value="Cerato-platanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07249">
        <property type="entry name" value="Cerato-platanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845502" evidence="5">
        <location>
            <begin position="20"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="18"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="45"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW86862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="254" mass="26229" checksum="E44C3E436443AB51" modified="2014-03-19" version="1" fragment="single">MKFTASFIAVAALFHGTAAAPQDGGAPPTPNSPSGTSATSAVTWSKPSTSPVYSSTTSTYSSTTSTTSPYTTTSATTTWYPSSTSSWYPPSTSSKPYPSSSSYPVPSSSHSYPPPPSGSATPPYPSNCPPNPNSNPLMMSLPLTYDNTYDNGSGSMNSVACSNGPKGLVERFPTFSDLPTFPYIGGAFAVGSWSSPNCGSCWSLTYPQTGVTIKLIAIDTSGVGFNAAQAAMDKLTGGKANQLGRIEVNAYQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMQ9</accession>
    <name>W4KMQ9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_471708</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67A family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543064.1">
        <property type="nucleotide sequence ID" value="XM_009544769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMQ9"/>
    <dbReference type="FunCoup" id="W4KMQ9">
        <property type="interactions" value="437"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KMQ9"/>
    <dbReference type="GeneID" id="20677410"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_471708"/>
    <dbReference type="eggNOG" id="KOG1556">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027018_3_0_1"/>
    <dbReference type="InParanoid" id="W4KMQ9"/>
    <dbReference type="OrthoDB" id="10256771at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000004">
        <property type="entry name" value="26S proteasome regulatory subunit rpn-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="17"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="292"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="293"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW86316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="338" mass="37041" checksum="A4BEB7ECDB2A50B6" modified="2014-03-19" version="1">MVATTTEQLTALAATTVVIHPLVLLSVTDHHARSVSKGSSKRVVGVLLGQDNGSTINVANSFGIPFEEDEKDSKTWFLDHNYIDGMFDMFKKVNARERMIGWYHTGPKLRASDLEINDLFRKFIARPVMVIVDVRPQTVGIPTDAYFAVEEIKDDGTETRSTFLHAPSAIEAEEAEEIGVEHLLRDIKDSTTTTLATRVSEQLASLRGLQSRIADIQKYLADVAAGAMPVNHQIVYHLQDALNLLPDLSDPALTSSFAASTNDELLVVYLSSLLRAVIALHALVDNKASIGRAEMEEGKGEQKKGVKSDAEKEKDGKKTPPESEKGKEKDSSKTDKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNK2</accession>
    <name>W4KNK2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_424232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541316.1">
        <property type="nucleotide sequence ID" value="XM_009543021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNK2"/>
    <dbReference type="STRING" id="747525.W4KNK2"/>
    <dbReference type="GeneID" id="20673955"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_424232"/>
    <dbReference type="eggNOG" id="ENOG502SN8X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079436_1_0_1"/>
    <dbReference type="InParanoid" id="W4KNK2"/>
    <dbReference type="OrthoDB" id="3227562at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="207" mass="23273" checksum="58EA2C4C055217E4" modified="2014-03-19" version="1">MDSNMDIDTAPFTFAVPQPPPEAMSDPIISSIPSPPHISHPTETREQFKAIPVKVHIRRPERDSWVYAGRGVVTLEVSGHSSQVVVRSTSTNKILTLFNETSDLQAEKRGNFVVIGCVEGSKVVSWSLNALNNAETLRLLASIELACYKCQQALGDPRTHYKSRRRIDRVIKDDRRKRHKRRKDQDAMVDAFSRQALSESAEPVPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNK8</accession>
    <name>W4KNK8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_447337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540644.1">
        <property type="nucleotide sequence ID" value="XM_009542349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNK8"/>
    <dbReference type="STRING" id="747525.W4KNK8"/>
    <dbReference type="GeneID" id="20675763"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_447337"/>
    <dbReference type="HOGENOM" id="CLU_357164_0_0_1"/>
    <dbReference type="InParanoid" id="W4KNK8"/>
    <dbReference type="OrthoDB" id="3257237at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="736"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="593"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="785" mass="82034" checksum="5CAF13C0762C9041" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPK3</accession>
    <name>W4KPK3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TPPC8 first Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_377708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540939.1">
        <property type="nucleotide sequence ID" value="XM_009542644.1"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KPK3"/>
    <dbReference type="GeneID" id="20671899"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_377708"/>
    <dbReference type="eggNOG" id="KOG1938">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004823_3_0_1"/>
    <dbReference type="InParanoid" id="W4KPK3"/>
    <dbReference type="OrthoDB" id="203724at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058541">
        <property type="entry name" value="Ig_TPPC8_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24545">
        <property type="entry name" value="Ig_TPPC8_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPPC8 first Ig-like" evidence="2">
        <location>
            <begin position="676"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW86981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1316" mass="146265" checksum="0F4B7E7BC9427ACE" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KQF9</accession>
    <name>W4KQF9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_11797</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Vesicular transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540254.1">
        <property type="nucleotide sequence ID" value="XM_009541959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KQF9"/>
    <dbReference type="FunCoup" id="W4KQF9">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KQF9"/>
    <dbReference type="GeneID" id="20666569"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_11797"/>
    <dbReference type="eggNOG" id="KOG3764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_51_2_1"/>
    <dbReference type="InParanoid" id="W4KQF9"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17325">
        <property type="entry name" value="MFS_MdtG_SLC18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="9"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW87640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="466" mass="50130" checksum="3A8FB658C247A721" modified="2014-03-19" version="1" fragment="single">PIGLKWRSSVWFITLGRCFSTQCARVATDMIIYSIVIPVLPFHLEHLGYSGISSLVGYLLFAYSGGLVISTPVIVWISERWTSRQAPLISGLVALICSQVMLMEARAYWVMAVARVIQGMSSSMVWTVGLALLCDTAPEHYLGQQLGLATSGLSLGLLIGPPVGGGLYSRFGFRAPFIFSITITALDLIGRLLIIERKDALSWGTGPAVCIIPDEESHRTSINSNTASVNGASKSSPSIDHPELIAAHTSDDSVGPKISQMTSIWSLLMSPRALTAMINTLILGYVPLAASQEPALPLHLQDVWGLDSSGVGLVFIAAVVPTLFSTPIAGWFADRKGAEWITILCMAFALPFWILITIEGKLPFFVVTFSFENLFTSAMVAPLTTELALVSKTLEGVGCKSYAHVYGAYNLAYGIGSSIGPIVGGRIYEHAKKGWMVLSLLDVGILSLAIILAFSFTGERPLLSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMX6</accession>
    <name>W4JMX6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_423496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553350.1">
        <property type="nucleotide sequence ID" value="XM_009555055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JMX6"/>
    <dbReference type="GeneID" id="20673908"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_423496"/>
    <dbReference type="HOGENOM" id="CLU_2320707_0_0_1"/>
    <dbReference type="InParanoid" id="W4JMX6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW74883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="99" mass="11254" checksum="06D9DFB5FFB87C0B" modified="2014-03-19" version="1">MAASGCVMPASKSQSLDKWMRISHPRRRAHSFLQITPQAKQVEALLRPWKGRSWEDFLGVWGSVEWFSSYKGGGNGVWALHHRVARVSPADRRGSQKCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNB1</accession>
    <name>W4JNB1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_456450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553422.1">
        <property type="nucleotide sequence ID" value="XM_009555127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNB1"/>
    <dbReference type="GeneID" id="20676742"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_456450"/>
    <dbReference type="HOGENOM" id="CLU_1415331_0_0_1"/>
    <dbReference type="InParanoid" id="W4JNB1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW74964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="192" mass="20260" checksum="EC4D390CCB89C20C" modified="2014-03-19" version="1">MSPLMAISTSLAAAGDGLPAEPSNVHCGSPARVRSDTTSCASLNLPLAALPGASERATTLWRARVQTSLSLGPLGIRKAITARVEGRNSILHKPSGTSWHKLRSALRRDRWCESNSVQVFSQAASIFATSAGHVLPLGATGRGSWGRLVALDRRAARPAFEMGENGRVIFRVQLASSTVGTDAGFREDQGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNF1</accession>
    <name>W4JNF1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_108657</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553100.1">
        <property type="nucleotide sequence ID" value="XM_009554805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNF1"/>
    <dbReference type="GeneID" id="20666365"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_108657"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006909_5_1_1"/>
    <dbReference type="InParanoid" id="W4JNF1"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000023">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="90"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW74595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="663" mass="72749" checksum="93572980D7295672" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2024-01-24" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNF7</accession>
    <name>W4JNF7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_108324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW75014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553466.1">
        <property type="nucleotide sequence ID" value="XM_009555171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNF7"/>
    <dbReference type="STRING" id="747525.W4JNF7"/>
    <dbReference type="GeneID" id="20666336"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_108324"/>
    <dbReference type="HOGENOM" id="CLU_1949096_0_0_1"/>
    <dbReference type="InParanoid" id="W4JNF7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW75014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="129" mass="14262" checksum="6FAC586682DA1A20" modified="2014-03-19" version="1">MTECTIPIIIEHTIEICQFRPNTIKPGLTISTETSSGTSVGSFRASFSCLSISSSSSLSMRMPAFDYITTPLSGVPIGSIDEKMTRPYMVCRMLTFPLDMSPTNYDLASLLHALHEYSSDYNLVSQQSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNU8</accession>
    <name>W4JNU8_HETIT</name>
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        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_332414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553227.1">
        <property type="nucleotide sequence ID" value="XM_009554932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNU8"/>
    <dbReference type="STRING" id="747525.W4JNU8"/>
    <dbReference type="GeneID" id="20671728"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_332414"/>
    <dbReference type="eggNOG" id="ENOG502S1MK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051552_1_0_1"/>
    <dbReference type="InParanoid" id="W4JNU8"/>
    <dbReference type="OrthoDB" id="21266at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070692">
        <property type="term" value="C:CTDK-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032786">
        <property type="term" value="P:positive regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042326">
        <property type="entry name" value="Ctk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024637">
        <property type="entry name" value="Ctk3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024638">
        <property type="entry name" value="Ctk3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291:SF1">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12243">
        <property type="entry name" value="CTK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12350">
        <property type="entry name" value="CTK3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW74740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="264" mass="30250" checksum="7A74760272D0573A" modified="2014-03-19" version="1">MQFLTLLRRLNASQQSIQKVVGYALKYYSRCGEDLWDCIVEECQKGSINNRINILYFLDSLCETSLLAKTHPTSQSSDKSSNNCFYVDYVSRDLGKIIEYVVPEGRQGLPNMMSTKQILESWRSKRIIDPQIVDSAMTSLDDRNAPTNSPPHSIPSPLASHSSDPAPLPRHEVFKRIEEDRERHKRLRERRWVQPVSHAPRIHQLASFMPLTDDGDGEDELTMDIEFENEWETTSDWNEDDDDAVGEENELCFPGEGEAPMDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JP06</accession>
    <name>W4JP06_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_164978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553272.1">
        <property type="nucleotide sequence ID" value="XM_009554977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JP06"/>
    <dbReference type="GeneID" id="20667956"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_164978"/>
    <dbReference type="HOGENOM" id="CLU_1563073_0_0_1"/>
    <dbReference type="InParanoid" id="W4JP06"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004843971" evidence="2">
        <location>
            <begin position="34"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW74795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="171" mass="19118" checksum="07AFC33588434C47" modified="2014-03-19" version="1">MGARPPRCFGRAGCCRFAPHFLFLLIASHGSLDLLTPAPSLSCRRFRFQSRHLHGSPSASYAHCSIIIHFPAFWHSIYSRSSSALHYLLLISTSLFLYLAYILRSLHTFRLLLLVSCQAGLLKCETPLPSAVSPHRKPRAENTLSARRFDVRRPGAVVMFTAGHTTQAPCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JP42</accession>
    <name>W4JP42_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_331448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552725.1">
        <property type="nucleotide sequence ID" value="XM_009554430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JP42"/>
    <dbReference type="GeneID" id="20671656"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_331448"/>
    <dbReference type="HOGENOM" id="CLU_2961067_0_0_1"/>
    <dbReference type="InParanoid" id="W4JP42"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="59" mass="6648" checksum="4268AB23D73FF452" modified="2014-03-19" version="1">MLACSWIRAVAEARTQYDARSCMSMPEMLILRNPTEAATASRRPRSGNSESKDDLWTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W4JP70</accession>
    <name>W4JP70_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-activating enzyme E1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_482048</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552754.1">
        <property type="nucleotide sequence ID" value="XM_009554459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JP70"/>
    <dbReference type="FunCoup" id="W4JP70">
        <property type="interactions" value="1126"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JP70"/>
    <dbReference type="GeneID" id="20678004"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_482048"/>
    <dbReference type="eggNOG" id="KOG2013">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_7_3_1"/>
    <dbReference type="InParanoid" id="W4JP70"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000011">
        <property type="entry name" value="Ubiquitin-activating enzyme E1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000004">
        <property type="entry name" value="Ubiquitin-activating enzyme E1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF5">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="11">
        <location>
            <begin position="16"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-activating enzyme SCCH" evidence="12">
        <location>
            <begin position="361"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="563"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="578"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="596"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW75323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="676" mass="72004" checksum="C11946526095D7F6" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQG8</accession>
    <name>W4JQG8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="13">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HETIRDRAFT_148882</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="13"/>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552751.1">
        <property type="nucleotide sequence ID" value="XM_009554456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQG8"/>
    <dbReference type="STRING" id="747525.W4JQG8"/>
    <dbReference type="GeneID" id="20667305"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_148882"/>
    <dbReference type="eggNOG" id="KOG0375">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_6_0_1"/>
    <dbReference type="InParanoid" id="W4JQG8"/>
    <dbReference type="OrthoDB" id="5593063at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="15">
        <location>
            <begin position="170"/>
            <end position="175"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="411"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="542"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="599"/>
            <end position="618"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
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            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
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            <begin position="542"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="601"/>
            <end position="618"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETW75320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="618" mass="70288" checksum="8AAF61041493EC23" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQK0</accession>
    <name>W4JQK0_HETIT</name>
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        <recommendedName>
            <fullName evidence="10">WH1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_390727</name>
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    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
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            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
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        <subcellularLocation>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:actin cortical patch"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Actin associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH1" evidence="7">
        <location>
            <begin position="18"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="6">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="133"/>
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        </location>
    </feature>
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        <location>
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            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="243"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW75166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="26960" checksum="1B912BF3E124C172" modified="2014-03-19" version="1" fragment="single">MPVQSTLTADEKNKLKAAIVPTGKIQTAALARIYFAHPDPNSWSYGGLQGALAFVMDNNKNTFFLRMVDLVGTRGVIWEHELYEGFEYFQDRLFFHSFPGDKCMIGLVFAEESEAKIFFKKVTKRKDTKSKPAKAPSTKKTSSNKSGKIDKSLISGPTEGSFKHVGHMGYDSEKGFVSSGVDPSWNTFLTDLESHGIDHELINQNMDFIKDFVRDAQKTAAATTAPPAAKKKKPPPPAPRRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQN7</accession>
    <name>W4JQN7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Scavenger mRNA decapping enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_329514</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIT family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552117.1">
        <property type="nucleotide sequence ID" value="XM_009553822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQN7"/>
    <dbReference type="FunCoup" id="W4JQN7">
        <property type="interactions" value="464"/>
    </dbReference>
    <dbReference type="GeneID" id="20671498"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_329514"/>
    <dbReference type="eggNOG" id="KOG3969">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041045_1_0_1"/>
    <dbReference type="InParanoid" id="W4JQN7"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <location>
            <position position="241"/>
        </location>
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            <position position="138"/>
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        <location>
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        <ligand>
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        <ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00010208"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        </source>
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    </evidence>
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            <dbReference type="EMBL" id="ETW75877.1"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="35719" checksum="78479239453EE6C7" modified="2014-03-19" version="1">MTLDLEQFQFERVLNEDPLAHAITLLGSLLSNTSGSDDVNPSAAIIRIEKTALPAFSDDLVGSTKLIESTDIYSWLFGWLRSSEERPDIKINVICPATEVHIRKYSRQQVHMVHETPALYARVVKPYIDAFPASRTQWVEDILSGASEAEKVLFRSPETDPHGFLILPDMKWDLSTVSALYLVALALEHGVRSLRDLRRVHVPMLKSIRREAYRIVKERWTLEPSELRCFVHYQPSYYHFHVHIVNANYVGLAGMSVGQAHLLDDIISMLELDPELGPSIFERMTLTYGLGDQHGLFEQMQIVQGEDGTSDEAGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4JR31</accession>
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    </organism>
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            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="59"/>
            <end position="315"/>
        </location>
    </feature>
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        <location>
            <begin position="104"/>
            <end position="144"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW76027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="586" mass="63025" checksum="07AE2578D4608D35" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JR78</accession>
    <name>W4JR78_HETIT</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">HETIRDRAFT_330134</name>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="20671552"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_330134"/>
    <dbReference type="HOGENOM" id="CLU_2250500_0_0_1"/>
    <dbReference type="InParanoid" id="W4JR78"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="104" mass="12007" checksum="C833326040E42F01" modified="2014-03-19" version="1">MPDRHSRRIRNIHFNELDLVPAFLCRDRKIELYTHVKASHLLYHLGSKALTGTYEAEGKSSSYCSSIFESGRSRCQDLIFFANVMYFIDSHVSKLLQVPATNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JS23</accession>
    <name>W4JS23_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_118693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551255.1">
        <property type="nucleotide sequence ID" value="XM_009552960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JS23"/>
    <dbReference type="GeneID" id="20666602"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_118693"/>
    <dbReference type="HOGENOM" id="CLU_1806416_0_0_1"/>
    <dbReference type="InParanoid" id="W4JS23"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="143" mass="15440" checksum="712EB41E38547956" modified="2014-03-19" version="1">MPKHAMKASRKGVPVCGEKKAGTAFPTRDLVSVACMHTANIEGKEGALVTTHSHGGFCEVAAENACMNSTEGTEHDEYSEHGMFGDNAGSLSSSISEAERQVEKSRQAPHAHESKYIVPAPAVRQKQGPWSQRPNPKRTRGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSE8</accession>
    <name>W4JSE8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">chitin deacetylase</fullName>
            <ecNumber evidence="20">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">HETIRDRAFT_148032</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polysaccharide deacetylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="20"/>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551297.1">
        <property type="nucleotide sequence ID" value="XM_009553002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSE8"/>
    <dbReference type="STRING" id="747525.W4JSE8"/>
    <dbReference type="GeneID" id="20667248"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_148032"/>
    <dbReference type="eggNOG" id="ENOG502QSK3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035539_0_0_1"/>
    <dbReference type="InParanoid" id="W4JSE8"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10952">
        <property type="entry name" value="CE4_MrCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.370:FF:000004">
        <property type="entry name" value="Related to Chitin deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF98">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="18" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="16" id="KW-0170">Cobalt</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 23" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844042" description="chitin deacetylase" evidence="23">
        <location>
            <begin position="31"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="24">
        <location>
            <begin position="144"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="366"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="ETW76379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="430" mass="46181" checksum="49C2831F1C8549BC" modified="2014-03-19" version="1">MRFQTFFTDTRASAQAHVLLLVSLALAASAQDRTTEKAEASITDPTQECTPYYYAPSANYIHNFPTIWQPATILPTDTAAQAKWASISSSVPTNIQPRGTAMGDFSNVTYDTVNDPACWWTAAKCTTPKLAGLQPDVSSVPEPKTIGYGFDDGPNCSHNAFYDYLQSKNQKATMYFIGSNVMDWPLEAQRALTDGHEICVHTWSHRYMTSFSSPDAFAELWYTMQAIKAVTGVTPTCWRPPFGDVDDRIRAIANGLGLQTILWKYDSNDWRAGVGGVTAQDVDNDYQSFINNATSGTFNTQGGIMLTHELNNFTMSEAMKYYPMLSSAFAHIVPVGVALNKTQPYVESNYSMPSFAQYIAGTSTSNGSSSTGSSSTSSSSSASSSSSSSHSDTSGGSAQGSKSAALPSTPLLSAHWAIVAGAGLLASLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4JT75</accession>
    <name>W4JT75_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_389252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551209.1">
        <property type="nucleotide sequence ID" value="XM_009552914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JT75"/>
    <dbReference type="GeneID" id="20672402"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_389252"/>
    <dbReference type="eggNOG" id="ENOG502SRW1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013871_2_2_1"/>
    <dbReference type="InParanoid" id="W4JT75"/>
    <dbReference type="OrthoDB" id="3261131at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052396">
        <property type="entry name" value="Meiotic_Drive_Suppr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="181"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="362" mass="40518" checksum="3142B801A96EEBA7" modified="2014-03-19" version="1">MVRQTLKLMQSVSQLAGQENERSESTRGLVSELLGQQLIRVMNGNNTSPDHCVSVSLDLHELMGTVTPFILEEKVEMGKTATDPSVQVQLSYLQYWMDPSRRNILEACCCPTILVGLAGPHMCITGAVLLDKAVVQHFTGWMFIGEDRTTGLDQVNDLGSPGVDRLAQIDSYPSNGQVIKFDYIKGLQQHESCTTFLARKVVNGEKEELVVVKFVDTYGKKVHEFMAEQGLAPRLIYFADLADRFSEQNYQGLSMVVMEHLEGDTLEAKYWDRALPSDVRGSIAQAIETLAKAGFVHGDLRRPNVMIDSEGKVKIIDFDWAGREMEVQYPLRISSFLFPENQGIEGRGEIRNAHDKFMLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTL3</accession>
    <name>W4JTL3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Diphthamide biosynthesis protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_327860</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71239"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:17998"/>
            <dbReference type="Rhea" id="RHEA-COMP:18001"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:33723"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]</text>
            <dbReference type="Rhea" id="RHEA:71235"/>
            <dbReference type="Rhea" id="RHEA-COMP:17996"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:33751"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DPH3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551646.1">
        <property type="nucleotide sequence ID" value="XM_009553351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTL3"/>
    <dbReference type="FunCoup" id="W4JTL3">
        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JTL3"/>
    <dbReference type="GeneID" id="20671364"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_327860"/>
    <dbReference type="eggNOG" id="KOG2923">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155991_3_1_1"/>
    <dbReference type="InParanoid" id="W4JTL3"/>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.660.10:FF:000001">
        <property type="entry name" value="Diphthamide biosynthesis 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF31">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPH-type MB" evidence="9">
        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW76774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="67" mass="7748" checksum="C63512E4E5287FD9" modified="2014-03-19" version="1">MGAYYDEIEIEDMAWDDEKAVYHYPCPCGDRFEISRKQLANYEDIATCPSCSLVIRVIYDPVSVFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTN7</accession>
    <name>W4JTN7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Iron-sulfur clusters transporter ATM1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Iron-sulfur clusters transporter atm1, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HETIRDRAFT_157028</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552453.1">
        <property type="nucleotide sequence ID" value="XM_009554158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTN7"/>
    <dbReference type="FunCoup" id="W4JTN7">
        <property type="interactions" value="366"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JTN7"/>
    <dbReference type="GeneID" id="20667684"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_157028"/>
    <dbReference type="eggNOG" id="KOG0057">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_1_1"/>
    <dbReference type="InParanoid" id="W4JTN7"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140466">
        <property type="term" value="P:iron-sulfur cluster export from the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18582">
        <property type="entry name" value="ABC_6TM_ATM1_ABCB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000004">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF402">
        <property type="entry name" value="IRON-SULFUR CLUSTERS TRANSPORTER ABCB7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="81"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="403"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETW76251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="654" mass="72577" checksum="751001D2430EB63B" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4JU34</accession>
    <name>W4JU34_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_422314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009553532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JU34"/>
    <dbReference type="GeneID" id="20673797"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_422314"/>
    <dbReference type="HOGENOM" id="CLU_1906981_0_0_1"/>
    <dbReference type="InParanoid" id="W4JU34"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="133" mass="13713" checksum="E059E72FB0563F75" modified="2014-03-19" version="1">MRCPDPRSSHPHLPLDLDTTHHPGTSSASSTFVNTSASNASFAVTATTAAASASSTSSRRSTESLRTRPSANRRDRDRTSQDRSKSMSAASTAHIRAALLDQASAAASASASSRTGRPCLPPASRPPSPLAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUY4</accession>
    <name>W4JUY4_HETIT</name>
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        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_152352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551759.1">
        <property type="nucleotide sequence ID" value="XM_009553464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUY4"/>
    <dbReference type="STRING" id="747525.W4JUY4"/>
    <dbReference type="GeneID" id="20667407"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_152352"/>
    <dbReference type="eggNOG" id="ENOG502RY7K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046025_2_0_1"/>
    <dbReference type="InParanoid" id="W4JUY4"/>
    <dbReference type="OrthoDB" id="3183258at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="171"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW76895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="310" mass="34854" checksum="44962F55460D10B0" modified="2014-03-19" version="1">MSDATTPNFARTIQGPMLLGTFFNLILYGIFLAQTFVYFQTYKRDRMWIKIVVALLIVVETSNSVLPISYSYDRLVNNFGNMPAAGVSTWLNTMNPMTIGIIATMVQLFYAWRVKVLTGRRWWMIAVIVPSIISCTGATVLSIVNLVDQSSITAVARYRPIVIVWLASSALTDTRNQRTGFSSTDDTVNKIIRLTVQTGLLTSVFAILDLTLYLSLQTAHHVMINLPLAKLYTNSLMSSLDSRQGRQYDSSNGSIIGSSQFKSASKRKTVRVYETQHRSHAYDVVCAAAKRFIIFSTITDAHRGKHRRYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVR3</accession>
    <name>W4JVR3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_327595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ETW77170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_327595"/>
    <dbReference type="eggNOG" id="KOG0592">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048610_0_0_1"/>
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    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW77170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="476" mass="52707" checksum="CF04F6B02DAFAD2A" modified="2014-03-19" version="1">MDQVVNEQRVMRAVDASGREGFLPLRASRHDSQNFYLVTPYCFKGDLARVIQFWGSGKIPHSLSRYYAAKLLKLLEGLHGFGIIHRDLNPANILFDAEGCPLIGDFGLARMFHVSYDLDGEVLLPMTGLFDRKADKPAKHTYLNCGTTAYMSPEALKRHLYSYESDLWSYSCILYEMLTGRAAFASADATLSEEAAFKPCDSVDPLTQIFVHLVLNKERADRPKLSAMKSHPYFISIDWERISKNEIKPSWVPLTRNPFMRSYIYLSIGPPTSPSQDPSPDFAFTSPDLFDITLPLTKETESSTPPCDPTAVECSALRGFFSKAFGCIKPTTPSLCVSNIPPSSVKEAQAVALNICPDLTKCGAGGDFICTTSTRSRAGDLSTPSSSSHASATNLLVRERQALMKHKALQCDEDPNMFDSLDQSSTQLCRPSLPAKISERTCVRVASMKLLDASAPSSKVGRWMKRLRAGWKAKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4JW63</accession>
    <name>W4JW63_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_52305</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550491.1">
        <property type="nucleotide sequence ID" value="XM_009552196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JW63"/>
    <dbReference type="GeneID" id="20678207"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_52305"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_27_1_1"/>
    <dbReference type="InParanoid" id="W4JW63"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="28"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW77131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="468" mass="50864" checksum="6E79B11E52A2DB7E" modified="2014-03-19" version="1">MASVVEDRARSDALVDHSSLPAVLKYILLIIFCFAQFLDAFNNSSLFAAIPPISVDLHIVNSTSVWLISAYQLTFAALLLSSGRLSDLYDPKYVFVAGMLLMSFCALGAGFVRVEVPLIVLRALMGVGAALNIPSAMALIIRLFPNPAAHFVLAILSFVLLPSTSYSPSPSLVGQARQYSRLKRLDLIGVSLLTAALVLFIFAVTSGSIDGWGSARVIAPLVLSVFLAVIFFLWELYLPESLAAVPPSMWKYRNFTILIAVGLQPFMWWAAVQLLFSWYYQEVFEWSTINTAVHFLPLGLVSFPTMGLASVLQQKFSLKWVILCGEIIVLAGTVLFPFADSKEHYWRFAFPGFCLGTAGMTMVFATTNIALFAITPPEVAGIVGAVFTCALQLGSAAGAAIVTSIQTSVQESHGGSNGFQGRSAGFWFLFAFTAVETLGVLFFMRNTVPPVVQQMEKERQIEAVGTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWH6</accession>
    <name>W4JWH6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_148662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_148662"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1204915_0_0_1"/>
    <dbReference type="InParanoid" id="W4JWH6"/>
    <dbReference type="OrthoDB" id="2903551at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW77794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="230" mass="25535" checksum="F9AF0D7B6AD0353F" modified="2014-03-19" version="1">MCPPFPHYATVTCDMKPNGLYSSYLLEPLHELPFDAPFQGLLTTPGHMLHASSLGLYDDTFTNERNFPSTPSPVNPYLISGYLHHRGEDRPPAPLLKDLDSFSEGTAIGSFNFSDTSEQDAGLRSLAFSPSHPRRSIEIWRNDVFLCLAFGKANALYSIDDCPPVVNSQGPATKRRRVSILELIDRPSFETPPLRAVVPSTLLHVDRQNVDIYQYSLGQDISRSSSAPPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWT2</accession>
    <name>W4JWT2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_148734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550022.1">
        <property type="nucleotide sequence ID" value="XM_009551727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWT2"/>
    <dbReference type="GeneID" id="20667293"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_148734"/>
    <dbReference type="eggNOG" id="ENOG502RD5E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081631_3_2_1"/>
    <dbReference type="InParanoid" id="W4JWT2"/>
    <dbReference type="OrthoDB" id="3830579at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="22230" checksum="8BB807F9EED47AAC" modified="2014-03-19" version="1">MAPAIEIVSWVASDAYLQDKSIVEGGVKFVLGVKGVLQVWSGLQIEKSRLFMVTVWDSIESHKALEADKEQYGKSLGLLGPTMAANPEVELYHAELDEDYPAAFNSPTVEFALITPTEEGATVETFKTLLAKLKVEAYKDTCTVLALSWGTIVEKPQTLLGVVGWKSIEAHHEEVKSGGFADVGKQFGAKGKIEFAHVHLAPGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWY7</accession>
    <name>W4JWY7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_454859</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551082.1">
        <property type="nucleotide sequence ID" value="XM_009552787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWY7"/>
    <dbReference type="GeneID" id="20676561"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_454859"/>
    <dbReference type="eggNOG" id="ENOG502S3F5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014996_0_0_1"/>
    <dbReference type="InParanoid" id="W4JWY7"/>
    <dbReference type="OrthoDB" id="10039566at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037">
        <property type="entry name" value="FORMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037:SF24">
        <property type="entry name" value="POLYCOMB PROTEIN PCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="520"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="692"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="549"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="607"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="702"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW77600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="871" mass="91093" checksum="E159B05BCC31A173" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4JX00</accession>
    <name>W4JX00_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450 monooxygenase 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">cyp13</name>
        <name evidence="12" type="ORF">HETIRDRAFT_67358</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549680.1">
        <property type="nucleotide sequence ID" value="XM_009551385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JX00"/>
    <dbReference type="GeneID" id="20678806"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_67358"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_25_0_1"/>
    <dbReference type="InParanoid" id="W4JX00"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11070">
        <property type="entry name" value="CYP56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845023" evidence="11">
        <location>
            <begin position="17"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW77984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="523" mass="60040" checksum="C8D75D975C4DD538" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXC1</accession>
    <name>W4JXC1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxybenzoate polyprenyltransferase, mitochondrial</fullName>
            <shortName evidence="9">4-HB polyprenyltransferase</shortName>
            <ecNumber evidence="9">2.5.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Para-hydroxybenzoate--polyprenyltransferase</fullName>
            <shortName evidence="9">PHB:PPT</shortName>
            <shortName evidence="9">PHB:polyprenyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ppt3</name>
        <name evidence="10" type="ORF">HETIRDRAFT_37087</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>an all-trans-polyprenyl diphosphate + 4-hydroxybenzoate = a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44504"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="9"/>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550461.1">
        <property type="nucleotide sequence ID" value="XM_009552166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXC1"/>
    <dbReference type="STRING" id="747525.W4JXC1"/>
    <dbReference type="GeneID" id="20671839"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_37087"/>
    <dbReference type="eggNOG" id="KOG1381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034879_3_0_1"/>
    <dbReference type="InParanoid" id="W4JXC1"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000008">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01474">
        <property type="entry name" value="ubiA_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW77536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="326" mass="36793" checksum="37E1F8C2AFAFD3CB" modified="2014-03-19" version="1">MAPTDATPLVKKNAEKLPFPLGLVSPGVRPYLELIRFHKPTGTILMFWPFAWGLTLAAYRTELPLNRYWVELAKSLFAAFIVRGSACTINDIFDREFDAGVERTKGRPLASGRVSVFAAVVYLIIQYIIGIMVYVSYNDIALYAAILQLLPLFLIYPLMKRITYWPQAWLGICMNFGLVVAWAAVTGGLDTQLLAVLMAGTWGWTMHYDTIYACQDRRDDIKVGVKSTAVMLGDYVRPFCFVLSMMFIGTLYYAGILNHQTPYYFWISVGGTALHILYQYATVDLDSPDSCGLNFIRNGHLGWITWAGMMVDYLVKIDQLPVKLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYF8</accession>
    <name>W4JYF8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protoporphyrinogen oxidase</fullName>
            <ecNumber evidence="4 11">1.3.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_479021</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:25576"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="EC" id="1.3.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.4" evidence="4 11"/>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549908.1">
        <property type="nucleotide sequence ID" value="XM_009551613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYF8"/>
    <dbReference type="FunCoup" id="W4JYF8">
        <property type="interactions" value="223"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JYF8"/>
    <dbReference type="GeneID" id="20677846"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_479021"/>
    <dbReference type="eggNOG" id="KOG1276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009629_1_1_1"/>
    <dbReference type="InParanoid" id="W4JYF8"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF3">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="479"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="479"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW77891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="573" mass="60407" checksum="C2889A93CEF3BBAA" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYK7</accession>
    <name>W4JYK7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_411189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549959.1">
        <property type="nucleotide sequence ID" value="XM_009551664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYK7"/>
    <dbReference type="GeneID" id="20672929"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_411189"/>
    <dbReference type="HOGENOM" id="CLU_1669596_0_0_1"/>
    <dbReference type="InParanoid" id="W4JYK7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="158" mass="16501" checksum="2FE553E77A8AD577" modified="2014-03-19" version="1">MSPNANVTAPAEAVTSIQASTVNDSSSGQDTQARKHMPVSGVFAAPVDGYTQILPRPQAALRQGQAGSDAFSLTTMTATPYVWPQGPFPYDYSQAPPPDIPSFSSAIPSPDISSSATSATSTPRLAQGLNLRSAEDLTAYLGRRDTRSDSITTPGKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYZ1</accession>
    <name>W4JYZ1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="3">7.2.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Cu(2+)-ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HETIRDRAFT_155925</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="3"/>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549079.1">
        <property type="nucleotide sequence ID" value="XM_009550784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYZ1"/>
    <dbReference type="FunCoup" id="W4JYZ1">
        <property type="interactions" value="372"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JYZ1"/>
    <dbReference type="GeneID" id="20667604"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_155925"/>
    <dbReference type="eggNOG" id="KOG0207">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_0_2_1"/>
    <dbReference type="InParanoid" id="W4JYZ1"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000144">
        <property type="entry name" value="copper-transporting ATPase 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00942">
        <property type="entry name" value="CUATPASEI"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0187">Copper transport</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="863"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="892"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="100"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00080126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ETW78768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="972" mass="103654" checksum="DA71AC31EAF45010" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0K2</accession>
    <name>W4K0K2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">MFS sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_35934</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548738.1">
        <property type="nucleotide sequence ID" value="XM_009550443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0K2"/>
    <dbReference type="STRING" id="747525.W4K0K2"/>
    <dbReference type="GeneID" id="20671807"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_35934"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="InParanoid" id="W4K0K2"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000115">
        <property type="entry name" value="High-affinity glucose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF17">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="26"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW78850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="535" mass="58143" checksum="0C45CFAD94E78428" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0L4</accession>
    <name>W4K0L4_HETIT</name>
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        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_324289</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009550694.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="20671039"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_324289"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069180_0_0_1"/>
    <dbReference type="InParanoid" id="W4K0L4"/>
    <dbReference type="OrthoDB" id="10675742at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
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    </dbReference>
    <dbReference type="SMART" id="SM00343">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
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    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
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    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="272"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW78671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="345" mass="40376" checksum="4E827D5B6B6A1C6B" modified="2014-03-19" version="1">MSTNPRNPESKGPAMAKPTPFDRNRKRTEQFLHEIDLMILARKYDFPDEFAKIAYALSYMKGGSAGIWSRNFTKSRNEADDWALYTWKETPEKTSVRKKISTDFEEFNKTSDARDKLARINQGKESFNAYLQLFEQIAELSGVDLETKKTHFLRGLKWELARGIYQDPAKQDTWEELVAKAKRHETMRIEEMRARDLRQGKYQVFTPSNYYSNIAPPRQERESQYVPMDVDAAEMEADAICTRFKKLTPEERSRLAKEGKCFYCKKPGHMARGCPSRPKQRFPPPSRGRFQPKRRMMRAMEEEEGGDEEDQEEGKQRVAHIQQMMMGLSMDEIEEVRAFSESKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0L5</accession>
    <name>W4K0L5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_478189</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549158.1">
        <property type="nucleotide sequence ID" value="XM_009550863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0L5"/>
    <dbReference type="FunCoup" id="W4K0L5">
        <property type="interactions" value="192"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K0L5"/>
    <dbReference type="GeneID" id="20677805"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_478189"/>
    <dbReference type="eggNOG" id="KOG1690">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066963_2_1_1"/>
    <dbReference type="InParanoid" id="W4K0L5"/>
    <dbReference type="OrthoDB" id="3427at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845095" description="GOLD domain-containing protein" evidence="9">
        <location>
            <begin position="26"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="35"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW78865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="221" mass="25508" checksum="3CAEE3E54840E8EC" modified="2014-03-19" version="1">MVPGSRPFPPLCSLFLLILVTTAHALHFYLDDNEKRCFIEELPTDTIVEGHYRALEWKEQSQIYEINDQLGILVEVDEMETGHSVVKTRGPPDGRFTFTSHDAGDHSICLSTNYSSSWFGPTAHIRLHLDVVVGAAKPDAEHDRSHISDIASKIRDLNMKLEDIRREQQYQREREADFRNLSEATNGRAVWYSVAQIVVLLATCAWQLRHLKRFFEDRKMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0N0</accession>
    <name>W4K0N0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_441320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549580.1">
        <property type="nucleotide sequence ID" value="XM_009551285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0N0"/>
    <dbReference type="GeneID" id="20675350"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_441320"/>
    <dbReference type="HOGENOM" id="CLU_1713515_0_0_1"/>
    <dbReference type="InParanoid" id="W4K0N0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="153" mass="17168" checksum="221B9634232670EC" modified="2014-03-19" version="1">MSSLSVRPAQQWIDLLYPSRPGILIGRLVPQNINISGRIGETWSFPTAFHGFRVLPSRAVLRELARIRPLCSRGGSRGRLSSSTVMYSGLSKPGSQRPRFMWTFCIMLAYAQPRGSNVQRGLVKMKWVAIEVATHPPVGIERTIVVRLGRHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4K159</accession>
    <name>W4K159_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase type 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_478113</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549109.1">
        <property type="nucleotide sequence ID" value="XM_009550814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K159"/>
    <dbReference type="FunCoup" id="W4K159">
        <property type="interactions" value="606"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K159"/>
    <dbReference type="GeneID" id="20677803"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_478113"/>
    <dbReference type="eggNOG" id="KOG2361">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029724_1_1_1"/>
    <dbReference type="InParanoid" id="W4K159"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052735">
        <property type="term" value="F:tRNA (cytidine-3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF11">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="318"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW78806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="47814" checksum="C2D17805183B82CA" modified="2014-03-19" version="1">MHLKSASSVRDPAARAPPFGSRSVPPVSLSLSLCRRHPPPARRLLTDDADVWSQNAWDHVPPPDDQDHLVAASLARQRAAPVPDHDQQKYNATPARHWDNFYQMNAANFFKNRKWLPLEFPELVAAAQPSAGPQTVVEIGCGAGNSIFPLLAQNTNPHLSIHAYDYSSHAVKLVQNNPLYAAPPCGSIHAAVWDLASSPAADGDGDGGDSDSALPPGLAPASADLLVLVFVLSALHPHEWPRALANIHQARPLRILKPGGRVLLRDYGRHDLTQLRFRAGRLLADNFYIRGDKTRVYFFELDELALLFTGARAPAQTTTAEHVVEDDSADADAGEGEGGGEGEGEGEGAAASASHTPDPDPDPSASASASATPEPSSSTLHPAPAPAPAPAIHPSLLPAPLRLPHCPPHPLFAAAQLGVDRRLLLNRKRQLKMYRVWMQAQFVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1C5</accession>
    <name>W4K1C5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_420104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549172.1">
        <property type="nucleotide sequence ID" value="XM_009550877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1C5"/>
    <dbReference type="GeneID" id="20673625"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_420104"/>
    <dbReference type="HOGENOM" id="CLU_032924_0_0_1"/>
    <dbReference type="InParanoid" id="W4K1C5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="479"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="83"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW78881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="512" mass="54753" checksum="3BE148B141D1EDFE" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1D7</accession>
    <name>W4K1D7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_247621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548210.1">
        <property type="nucleotide sequence ID" value="XM_009549915.1"/>
    </dbReference>
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        <property type="entry name" value="OS04G0603800 PROTEIN"/>
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    </dbReference>
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            <end position="110"/>
        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="110" mass="12873" checksum="F109627B12A00235" modified="2014-03-19" version="1" fragment="single">GTHIRTTHPKFKLAPRRYGPFKILGKVGTLAYKLQIPPQWKIHPVFHAAVLTKYRETEAHGENFARPIPEVLNDEEHYEVEMIVDSKRQGRGTKYLVKWMGYPESDNTWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
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    <name>W4K1F3_HETIT</name>
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        </alternativeName>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
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    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
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        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
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        <location>
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            <end position="153"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="174" mass="19651" checksum="3E0398764B6E3F78" modified="2014-03-19" version="1">MASKAAYKRLSKEYVTMQKEPPPFVWAAPDEKDILTWNYVLRGPPDSPFAGGEYHGVLLFPSEYPFKPPGIKMYTPSGRFQPDKKICFSMSDFHPGSWNPAWSVATILTGLVSFMLSDEMTTGSVTTSDADKRTYAARSHIWNIEQRRFKEAFPDVSLPVIQHITIAITPPYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1U3</accession>
    <name>W4K1U3_HETIT</name>
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        </submittedName>
    </protein>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_441174"/>
    <dbReference type="HOGENOM" id="CLU_1360565_0_0_1"/>
    <dbReference type="InParanoid" id="W4K1U3"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="201" mass="23145" checksum="31367E8350058CBE" modified="2014-03-19" version="1">MVKRVCSQSTDTRNQKQIPTPMATQDSVSSSAVPNPSTSRDANLVRQIPLNTRDNSQYLEAWEHAPISPQPMDVDSPSITKPSRSPPPPQSSSLRKVLNPPFLLEHFHMDLLLLRFFPEYSRTGPPPEFQRIAYILVLTCLELDRERFKKADDFDDLLQSFPVLDSISKDCWREGSFRALRELEIFWPDPDKLFKREVSCE</sequence>
</entry>
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    <accession>W4K1W8</accession>
    <name>W4K1W8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleoporin Nup186/Nup192/Nup205</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_435087</name>
    </gene>
    <organism evidence="5 6">
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        <lineage>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Bondarzewiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
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        <property type="protein sequence ID" value="ETW79734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009549997.1"/>
    </dbReference>
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        <property type="interactions" value="502"/>
    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_435087"/>
    <dbReference type="eggNOG" id="KOG1835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001071_0_0_1"/>
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    <dbReference type="OrthoDB" id="2019644at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of nuclear pore"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW79734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2109" mass="234536" checksum="83559D4E8639CBD4" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1X4</accession>
    <name>W4K1X4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type E3 ubiquitin transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_420283</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Solheim H."/>
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                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MKRN-like"/>
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        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
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        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
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        <property type="entry name" value="IP09428P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MAKORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="83"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="164"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="164"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW79111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="25401" checksum="883EE3D28E3E5E8E" modified="2014-03-19" version="1">MDRPSTSKPRGLCLYFNTPRGCFRGSQCKFLHGADEKLTPHDKHKTCKWFAAGYCKRGADCWFRHVLAPPSEEPLPALSEDTCGICLEKPVTFGLLSNCSHVFCVDCIRGWRLRENKSEDIRFSRVNKKCPYCRSDSKMIVPSSHFYPDDHPGKAAVIKSYKASMALVKCKYFEESPEEEKFCPFGHDCLYKHENADGTPHVFPRGVDFYMTVSQSPSLVLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4K208</accession>
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        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">HETIRDRAFT_323216</name>
    </gene>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
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            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009551313.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="20670949"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_323216"/>
    <dbReference type="eggNOG" id="ENOG502QVC6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005049_5_1_1"/>
    <dbReference type="InParanoid" id="W4K208"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="47"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW79375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="422" mass="48145" checksum="29BFED4F4FC0A317" modified="2014-03-19" version="1">MEDPTAYVSHPDISHEREHPRTGKYSQSEQIPDETKLTTCECKDSGRNLVVCIDGTSNQFGQKNTNVIEMYRDLVKDDMQVTFYNSGIGTYARPSWKSWSYLKQVVDNTIDLAIAWNFEKIIISAYHWLSENYRSGDRIFLFGFSRGAYQVRALSAMIAKVVGLIHRGNEDQIPFAYELYAKPRPSKSQEKEGPTAEMFKETFSHNVRVHFVGAWDTVSSVGILRDKTLPNTAEGMHHVCFFRHALALDERRVKFLPEYTYGGRASKEESYSERFTSSVQHAEDSIPHTKEVWFAGTHSDIGGGNSKNSNLDRGKPALRWMSREAESVGIHFAPRLTRWEWEKLGAVNESLTLAWKFIELLPIRRLSYKGKNITTFRPHLGKGRRIDIGQQLHASVIFSSNKLYKPRAQLWPDGGGNSNLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2J8</accession>
    <name>W4K2J8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_155674</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548577.1">
        <property type="nucleotide sequence ID" value="XM_009550282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2J8"/>
    <dbReference type="FunCoup" id="W4K2J8">
        <property type="interactions" value="252"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K2J8"/>
    <dbReference type="GeneID" id="20667587"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_155674"/>
    <dbReference type="eggNOG" id="KOG1965">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005912_5_0_1"/>
    <dbReference type="InParanoid" id="W4K2J8"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF187">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="41"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="507"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="610"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="644"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW80053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="655" mass="70963" checksum="19859D0FD4B9E3B6" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3D6</accession>
    <name>W4K3D6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_122960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547100.1">
        <property type="nucleotide sequence ID" value="XM_009548805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3D6"/>
    <dbReference type="STRING" id="747525.W4K3D6"/>
    <dbReference type="GeneID" id="20666799"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_122960"/>
    <dbReference type="eggNOG" id="ENOG502SJSB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054233_0_0_1"/>
    <dbReference type="InParanoid" id="W4K3D6"/>
    <dbReference type="OrthoDB" id="195231at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844277" evidence="2">
        <location>
            <begin position="21"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW80338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="317" mass="35259" checksum="7F5E68434A3C7520" modified="2014-03-19" version="1">MFILFTLYLTSVPLIHYALASSPMLGSPCTTAHDHLDPHTRALLTSCDAQTVCSAPLNGTCRARSCRRDTFAFGYASDDPIPPLCPSDSFCPDEGDECRSLVTPGQGCQFNRDDQCAPPEDPDPAIELSDPQNNKGAICVKSVCMYVLFWSSDWYREYMTSIFTRVSRYANVTAGQSCVYELTGYTTADHDGQDSTNIIVRDNCRTAELFCDTSTSLCVPVKEIGQQCQYDRDCRSYTCLNNACASSSDAPVDVAIWQYIVTCISIIAAMITTCVMLTLMHKRNRVESYNETRDYCYEQITSVSALMSIAWWRSDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3T1</accession>
    <name>W4K3T1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_452079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547233.1">
        <property type="nucleotide sequence ID" value="XM_009548938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3T1"/>
    <dbReference type="GeneID" id="20676225"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_452079"/>
    <dbReference type="HOGENOM" id="CLU_621213_0_0_1"/>
    <dbReference type="InParanoid" id="W4K3T1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="441" mass="48366" checksum="0A25098D7198AD0F" modified="2014-03-19" version="1">MAVDDRVGDFAGCWLLAAGCWLLAACRSRDLWRVVPLVESVLSRPELGLKKWLFTVAHSRFFCDTSRYVLIHPVGCSFTFLSDARLVPFTPIPSGSLPLVPLHSVRPGLVLTLKHHAFRARPSLSTSAHAGALRLVAIRRTHRAMRPRQAPIVGFVSGIAVSSRIPVPAHACARFIAWARALPSRASSARLRLWFLVTCNGPPGFWTARISPLPGPRQLLVTAHSHLILVRCGGSRRARSTPSHTFMATLVRITPLAHRRPRKCTPLASTRIRLAESRSALGQGSLFAAPSRQLAAAPVRASSVLGTVVLPPAERREATCSSAQVSEKKSSLGPYQPGRNALRPAPRPSSANPSFGTQVDGDGTSWPIDDGVDPSRLVSFYVTSRVVRMVRYDTTQYDTTQYNTARHESVTYLHHDARRLWRASSSHRGRPHTLAHPLHAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3X2</accession>
    <name>W4K3X2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA topoisomerase</fullName>
            <ecNumber evidence="3 7">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_46055</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3 7"/>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546939.1">
        <property type="nucleotide sequence ID" value="XM_009548644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3X2"/>
    <dbReference type="FunCoup" id="W4K3X2">
        <property type="interactions" value="802"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K3X2"/>
    <dbReference type="GeneID" id="20677089"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_46055"/>
    <dbReference type="eggNOG" id="KOG1956">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002929_1_1_1"/>
    <dbReference type="InParanoid" id="W4K3X2"/>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.140:FF:000005">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF21">
        <property type="entry name" value="DNA TOPOISOMERASE 3-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPO_IA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="9">
        <location>
            <begin position="162"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW80507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="674" mass="77566" checksum="5D37F9E7574F49AE" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3Y9</accession>
    <name>W4K3Y9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_319714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
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</entry>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
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                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
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                <person name="Yakovlev I."/>
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        </source>
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    </evidence>
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                <person name="Cullen D."/>
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        <location>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLASP family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547439.1">
        <property type="nucleotide sequence ID" value="XM_009549144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4G0"/>
    <dbReference type="GeneID" id="20669158"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_247238"/>
    <dbReference type="eggNOG" id="ENOG502S11N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110329_0_0_1"/>
    <dbReference type="InParanoid" id="W4K4G0"/>
    <dbReference type="OrthoDB" id="46159at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CLASP N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW80723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="170" mass="18433" checksum="5390A39614EB59CF" modified="2014-03-19" version="1" fragment="single">FPTAFTSALRPLSRAVTSAASSERTRLSAASIQFICAAAMGLGKAFEPLLPLYFPTLLSLCARPNKVFIARAKTGIATIIEQTQLPAILSFLIEPLKDKSVSLRLIAIEGLLACLNCFNPPDLEKESRAREIETAIKITAQDASGDVRKVSKQVFGAYKILLPNRVDRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4L2</accession>
    <name>W4K4L2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glyoxal oxidase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">glox2</name>
        <name evidence="6" type="ORF">HETIRDRAFT_146345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547412.1">
        <property type="nucleotide sequence ID" value="XM_009549117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4L2"/>
    <dbReference type="GeneID" id="20667133"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_146345"/>
    <dbReference type="eggNOG" id="ENOG502QPS4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009630_3_0_1"/>
    <dbReference type="InParanoid" id="W4K4L2"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF21">
        <property type="entry name" value="LOW QUALITY PROTEIN: ALDEHYDE OXIDASE GLOX-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844294" evidence="3">
        <location>
            <begin position="20"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="Glyoxal oxidase N-terminal" evidence="4">
        <location>
            <begin position="133"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose oxidase-like Early set" evidence="5">
        <location>
            <begin position="486"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="617"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="622"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW80694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="661" mass="69422" checksum="6D52D7EC5C6ACED7" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5U0</accession>
    <name>W4K5U0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_434942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547848.1">
        <property type="nucleotide sequence ID" value="XM_009549553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5U0"/>
    <dbReference type="GeneID" id="20674787"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_434942"/>
    <dbReference type="HOGENOM" id="CLU_1090125_0_0_1"/>
    <dbReference type="InParanoid" id="W4K5U0"/>
    <dbReference type="OrthoDB" id="3259102at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="255" mass="27795" checksum="B72B4403F2AB78C0" modified="2014-03-19" version="1">MIDHEQAPACSDPSCREPPLLDLPWPPARIFLSSLPDQDTVHLPAFKQPTMLHLVGLTDAEFWNADLGTGAALVAVLQLVAVPTTTALRAQTATRSYMHRPTIEVSDLVILNITPEATALRRAVLRDVLTPFKIAVMAAKSIISYFRSAKQRCISLVGMNGWSPHCARIQTQGQSACPDDSAGIYRYRSTPATPTCPARGRKLEVEIISDPRKHTSGLVEVLTMLNQTVYVFGHGKNVVVGGPIWSTDDEGGHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6I1</accession>
    <name>W4K6I1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_61766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546968.1">
        <property type="nucleotide sequence ID" value="XM_009548673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6I1"/>
    <dbReference type="GeneID" id="20678570"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_61766"/>
    <dbReference type="eggNOG" id="ENOG502SCD9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148795_0_0_1"/>
    <dbReference type="InParanoid" id="W4K6I1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17249" checksum="24FA83743C2941CB" modified="2014-03-19" version="1">MGASASEFSPAPLAERVLSPPPSNPSRHIPPPAPPTILAPPPTGNQRSSAPHEPFLAHAPPPPDSWIAVETMPREYTLVVRLPGFGRDGITLATRRRRILHLVADSWEPGGGHFERRISFGYDADLAQVRAEFDGELLRVIIPRRTPAITWYGEARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6I9</accession>
    <name>W4K6I9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_320900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547647.1">
        <property type="nucleotide sequence ID" value="XM_009549352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6I9"/>
    <dbReference type="GeneID" id="20670703"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_320900"/>
    <dbReference type="HOGENOM" id="CLU_2277864_0_0_1"/>
    <dbReference type="InParanoid" id="W4K6I9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW80960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="102" mass="11370" checksum="9A2911B951AC2830" modified="2014-03-19" version="1">MFPPAFLFSSWVDYGYLCARGCVLAYCCRRARAPACPVGCLAGMWCGAARWCCNTDKWPRRGFMIGLLSPCRRESRPTDAACHGGGFDFGVRPEGEKQLRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6Z7</accession>
    <name>W4K6Z7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 71 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_51383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545841.1">
        <property type="nucleotide sequence ID" value="XM_009547546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6Z7"/>
    <dbReference type="GeneID" id="20678179"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_51383"/>
    <dbReference type="eggNOG" id="ENOG502RTMK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019141_4_0_1"/>
    <dbReference type="InParanoid" id="W4K6Z7"/>
    <dbReference type="OrthoDB" id="3257981at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="479" mass="52211" checksum="583B4B362CF7D7DE" modified="2014-03-19" version="1">MPSPTSSNVQPAPSAPPQASPGASRKYVIAHHMVGNTYPYTVDNWVADITLAHAHGIDGFALNMGRDDWQPARVADAYHAANMSGTGFKLFLSFDMSSLPCSSPNDAATLRNYITTYAMHPNQLIYDGRVFVSTFAGESCTFGQASPAQGWSSQFTQHPQLTGRNAVYFVPSFFVDPNTFSTFNDAMDGALNWNSGWPITLTTSSANSILSSVGVSLSSLTSSVGSIVQKTLSRFVTSTDSDTQYIKGLSTMSNKGRKRAYMATVSPWFFTHYSPQTFNKNFIYYADSHLYPARWETLISSRDKVDIVEIVTWNDYGESHYIGPIEGAQPNSQAWVDGLNHTGWLDMTSYYATAFKTGAYPAITKDKIYMWSRTHPRDANAPDPVGKPANFELTEDALWAVAMTTAPATVTLSTGNGKMQAFNVPAGMNKLSIPISAGGTMHGTIARNGKTVVDFHPQGFTFNGSPQTYNYNAFVAVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4K788</accession>
    <name>W4K788_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_320739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547608.1">
        <property type="nucleotide sequence ID" value="XM_009549313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K788"/>
    <dbReference type="STRING" id="747525.W4K788"/>
    <dbReference type="GeneID" id="20670688"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_320739"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1801158_0_0_1"/>
    <dbReference type="InParanoid" id="W4K788"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW80916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="180" mass="19892" checksum="B2CC41FD1F4AF6C7" modified="2014-03-19" version="1">MSKRKKVKSKAHPRTKNVPKIDRKFRCPLCGGMFKFPSSIALHIESGACNNISRHQVTSAIHALNVIPRISLSHRIAGPGGLPGGTIVRYSANRQAFNGFAYECYFCHRTFCTLASLNAHLGSAAHDKNQFKCPRCNKPFKLISGLIQHVESGTCGAAKFKQVEDMASRMTGQFARLLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4K813</accession>
    <name>W4K813_HETIT</name>
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        <recommendedName>
            <fullName evidence="8">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_125032</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546133.1">
        <property type="nucleotide sequence ID" value="XM_009547838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K813"/>
    <dbReference type="FunCoup" id="W4K813">
        <property type="interactions" value="774"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K813"/>
    <dbReference type="GeneID" id="20666894"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_125032"/>
    <dbReference type="eggNOG" id="KOG1991">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004196_0_0_1"/>
    <dbReference type="InParanoid" id="W4K813"/>
    <dbReference type="OrthoDB" id="760868at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF18">
        <property type="entry name" value="D-IMPORTIN 7_RANBP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="24"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="925"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="973"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="925"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="936"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="982"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW81490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1061" mass="118146" checksum="058DBA0839EEC767" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4K872</accession>
    <name>W4K872_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_451672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009548311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K872"/>
    <dbReference type="GeneID" id="20676183"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_451672"/>
    <dbReference type="HOGENOM" id="CLU_1366404_0_0_1"/>
    <dbReference type="InParanoid" id="W4K872"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="200" mass="21922" checksum="B266CB3A156E9A6C" modified="2014-03-19" version="1">MIANLSLSRDPLARPNVSRPPPSSEHSPSRWTSDGRQPQVARTSSRMSSRTRMRSSDPSTLIHSVLSSFPHDDNTSQNTRHEAPLCLGPQKFYLCTRASLLRSLTLHSLSRSDAHTDPQPGAIFETIEKALAAGNRRRQLSLVVEGPKPAPHLPTQHPASRALHIPFESLGPRNPPPASDVDRSDQLGRSIEPHAFDACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8K1</accession>
    <name>W4K8K1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_61357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
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    </evidence>
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                <person name="Yakovlev I."/>
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                <person name="Fossdal C.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546652.1">
        <property type="nucleotide sequence ID" value="XM_009548357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAG6"/>
    <dbReference type="GeneID" id="20670461"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_317933"/>
    <dbReference type="HOGENOM" id="CLU_2967251_0_0_1"/>
    <dbReference type="InParanoid" id="W4KAG6"/>
    <dbReference type="OrthoDB" id="3059824at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="59" mass="6617" checksum="0B36ABBE2D8A6513" modified="2014-03-19" version="1" fragment="single">VFAKKFNRDSRVIGYKAYLVGKGYSQKFSINFLWTSVAVICLETVCTALVLTAILNLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAU5</accession>
    <name>W4KAU5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_426150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544845.1">
        <property type="nucleotide sequence ID" value="XM_009546550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAU5"/>
    <dbReference type="GeneID" id="20674084"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_426150"/>
    <dbReference type="eggNOG" id="ENOG502T1S7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_973371_0_0_1"/>
    <dbReference type="InParanoid" id="W4KAU5"/>
    <dbReference type="OrthoDB" id="2800032at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="286" mass="32522" checksum="00E947381BAD4317" modified="2014-03-19" version="1">MERECEVWSGERSYESLSRRTPSVPQATICRIKPRIPRLEERNIDSEERSLDSDIEGGFMDVNVAIPKEDAVKAKRLLLPKWAKKHWGSKIIPTLLDFYGIQDNPWNLDGDNGVTLFHTALQQTINLVCPGIKYTPMLVRDKVYLIARQAVYDWHRRFQTKAIQAVKSTVASLGNKNTVKAFVQKALQPKYRAAYWAMPDPERPEGAMQSICIVKVLAMHVKSTQGSIFTQKYYPVGSLCLAVLAMTYSTGSFKPLNTSFSEEHCGTKTQDLRQGLTIWTFLKKPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAY5</accession>
    <name>W4KAY5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_458575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545289.1">
        <property type="nucleotide sequence ID" value="XM_009546994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAY5"/>
    <dbReference type="GeneID" id="20676927"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_458575"/>
    <dbReference type="eggNOG" id="ENOG502SS3D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084280_0_1_1"/>
    <dbReference type="InParanoid" id="W4KAY5"/>
    <dbReference type="OrthoDB" id="3256331at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046528">
        <property type="entry name" value="DUF6593"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20236">
        <property type="entry name" value="DUF6593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6593" evidence="1">
        <location>
            <begin position="14"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="201" mass="22496" checksum="B9807562924C25F9" modified="2014-03-19" version="1">MSDPSISILSFKPDNPCNTSLVNEEGVEIYAVHTDFADELKPTTRVNDAYGKCIAEWVWRDVRSDLLTFKDKPQIPASAWLHKSLIPFNSDVTFEDGSGRKYKWKNISPGVYPQLFSGESKNQPIARFQRALKDPQGVNRPVLRSAQLLLDARADEIRDMVVVSFLILERRRRESSIESDSRASVMAVSVSMAGSLASGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KB39</accession>
    <name>W4KB39_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_427349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546806.1">
        <property type="nucleotide sequence ID" value="XM_009548511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KB39"/>
    <dbReference type="GeneID" id="20674200"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_427349"/>
    <dbReference type="eggNOG" id="ENOG502R17T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_771740_0_0_1"/>
    <dbReference type="InParanoid" id="W4KB39"/>
    <dbReference type="OrthoDB" id="3236755at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="359" mass="41021" checksum="3D4E0D9148D66065" modified="2014-03-19" version="1">MLHLFLVTGYPRSDFLINSATANPVIVIPKQGSDLNIPHPRLFNCMKAFLRDEMLKPMVEHMDTHPEGMHPVLKRLGSAMAIAKFQLQLDAYWWEKAPFDRAKPIQDGDVLGWWWQFTNNPEADILAMLAEKVFSILVNSMLDERTSSRFTWFNSALRGHLCAQLLMDMTVIGQWYGTHVTEDKVPKKRPTIKFRNLEDNLKAASLVHHPRALLTWRTLPPLPWMALILMTTQTTRTMTQMADREDPRAGLLHSISCRSLQSVRRPSWICYLILQVADNAEPKRTLIKSPTWGSWGIYSNIDNAREVEVECDDVGVSEWENTRWNGGDIHGLNMGMEVEVEVVGIECGKVEGNSRGRMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KB73</accession>
    <name>W4KB73_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_316313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544963.1">
        <property type="nucleotide sequence ID" value="XM_009546668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KB73"/>
    <dbReference type="STRING" id="747525.W4KB73"/>
    <dbReference type="GeneID" id="20670318"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_316313"/>
    <dbReference type="eggNOG" id="ENOG502SQSS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141388_0_0_1"/>
    <dbReference type="InParanoid" id="W4KB73"/>
    <dbReference type="OrthoDB" id="412006at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17632" checksum="9F43269D95F729A4" modified="2014-03-19" version="1" fragment="single">FFSQDETQTPSPMDHSYPELAFPFRSITNAQIYRAIERLHGLKAPGNNGIPNIVYKNCASILVPFLGPIFHTTFSLGIYPQDWKDSQTLVLQKLGKLDYSNPNAYRPTALLRTITKILSACIASELMQLAELHHLLPDTHFGCRAGQKTTDSLHYVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBA4</accession>
    <name>W4KBA4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_247006</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545367.1">
        <property type="nucleotide sequence ID" value="XM_009547072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBA4"/>
    <dbReference type="FunCoup" id="W4KBA4">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="GeneID" id="20669139"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_247006"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078327_1_0_1"/>
    <dbReference type="InParanoid" id="W4KBA4"/>
    <dbReference type="OrthoDB" id="19174at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="123"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="123"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW83083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="218" mass="22850" checksum="FA7F5ED5DABB8E6E" modified="2014-03-19" version="1" fragment="single">KNIWVAAGDGDLARVQLMSHPIVIAISPNAPDPYTYTPMHAAASYGQLHVLDYLISRGGDVNTTDDDGDTPLYTVENVETARYLVEHGATVDRRNNEGIQPAEHLAEDFPEVASYLAALAPAPAPHATDASGTPSPASPAPALALAPGAARGLAQPSQHSQDAVSEYLTASLLQSVQDIMGRAEAEGRDPDEELRQVVGRTVLEGVVAGYGMSETAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBK4</accession>
    <name>W4KBK4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor Pcc1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_426547</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545455.1">
        <property type="nucleotide sequence ID" value="XM_009547160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBK4"/>
    <dbReference type="FunCoup" id="W4KBK4">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KBK4"/>
    <dbReference type="GeneID" id="20674123"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_426547"/>
    <dbReference type="eggNOG" id="ENOG502SBSA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113770_4_1_1"/>
    <dbReference type="InParanoid" id="W4KBK4"/>
    <dbReference type="OrthoDB" id="10025739at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000005">
        <property type="entry name" value="L antigen family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283">
        <property type="entry name" value="EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283:SF5">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT LAGE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW83173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="11118" checksum="1C8C0C2E8F038CD1" modified="2014-03-19" version="1">MLDSTSAVTDWHTISLRIPFATTKHATIAKQVLEVDRELQPHAVKRELAVEGDVLVATFSTLTVRLARLTLNGFLESVDLVVRTISEFGEEAERLLIASAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBR5</accession>
    <name>W4KBR5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_120782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544872.1">
        <property type="nucleotide sequence ID" value="XM_009546577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBR5"/>
    <dbReference type="GeneID" id="20666715"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_120782"/>
    <dbReference type="HOGENOM" id="CLU_1230078_0_0_1"/>
    <dbReference type="InParanoid" id="W4KBR5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="225" mass="25708" checksum="704489B3789D1F1F" modified="2014-03-19" version="1">MDQEHCGKDKKDIAISARDEGTAVVDEEECVRVTGVVFDDRGLGARRRVSEAEESVTAHTLEQDLGQEYPPGTRRINNQLRHNNRPIRREGDFWLYEDNNRFALLNYNNCSYRNGRYYFTLEDGTEEEDIWNETEAQWELAPQYREPAPVIPEDSEQEETTSESDSDSPKQTPINTRNESFADMSGQALTSTDPPSATVQPGRGKVKLPDNYTGNHIESQKFMLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4KC11</accession>
    <name>W4KC11_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_163074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545567.1">
        <property type="nucleotide sequence ID" value="XM_009547272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KC11"/>
    <dbReference type="STRING" id="747525.W4KC11"/>
    <dbReference type="GeneID" id="20667821"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_163074"/>
    <dbReference type="HOGENOM" id="CLU_1594747_0_0_1"/>
    <dbReference type="InParanoid" id="W4KC11"/>
    <dbReference type="OrthoDB" id="2535105at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="167" mass="18982" checksum="11A2A7EBD1E0F7EE" modified="2014-03-19" version="1">MPSEAALNTTLGPFLLGYTAVAILFGITNVQAFMYCMHSWKRDTWKLRSFVLFLWFLDALQMALTAHCVYYYLILKFGDLDNLVTEPVVWSLTVRISGTYPPGSLFNHCWLNGDLPGSVDRHGFRRFSCSGVRRSRVRSFIHRADDLSDSIVNDCGNWITTSECLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCD0</accession>
    <name>W4KCD0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Metallo peptidase M1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_38387</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544620.1">
        <property type="nucleotide sequence ID" value="XM_009546325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCD0"/>
    <dbReference type="FunCoup" id="W4KCD0">
        <property type="interactions" value="528"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KCD0"/>
    <dbReference type="GeneID" id="20672172"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_38387"/>
    <dbReference type="eggNOG" id="KOG1046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003705_0_2_1"/>
    <dbReference type="InParanoid" id="W4KCD0"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000006">
        <property type="entry name" value="Puromycin-sensitive aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="13">
        <location>
            <begin position="130"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="11">
        <location>
            <begin position="368"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="12">
        <location>
            <begin position="664"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW82731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1006" mass="110562" checksum="0A6986076D841A49" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCK6</accession>
    <name>W4KCK6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_474620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545720.1">
        <property type="nucleotide sequence ID" value="XM_009547425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCK6"/>
    <dbReference type="STRING" id="747525.W4KCK6"/>
    <dbReference type="GeneID" id="20677575"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_474620"/>
    <dbReference type="eggNOG" id="ENOG502SQDH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045218_2_0_1"/>
    <dbReference type="InParanoid" id="W4KCK6"/>
    <dbReference type="OrthoDB" id="5584477at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="58"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="307"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="532" mass="60405" checksum="BF2FB66BDE58DC80" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCQ3</accession>
    <name>W4KCQ3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_150735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543342.1">
        <property type="nucleotide sequence ID" value="XM_009545047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCQ3"/>
    <dbReference type="GeneID" id="20667371"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_150735"/>
    <dbReference type="HOGENOM" id="CLU_1214900_0_0_1"/>
    <dbReference type="InParanoid" id="W4KCQ3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="228" mass="24366" checksum="698822D1F45218BA" modified="2014-03-19" version="1">MSGSNEFTKALFQELYEGVPFLGPDGPLDVAGFDFLPGTHNLGEVSGEYRPDLAGADLLPPEGSKEEAELMRILEESGLCGNPSATNYSQGFSAFTSNTAFSGPVPASVENERFLQVAAAPQGLSQMSNFPVPAPHHMPSTQILADRFAMADNTTPLPAISCRKRPLEDDGAGWSTSKRGRWHDASAMGQVFPPTHSISKPSAARDISPLPVQSRSLCHCQPKGLGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCU0</accession>
    <name>W4KCU0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_450816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545437.1">
        <property type="nucleotide sequence ID" value="XM_009547142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCU0"/>
    <dbReference type="GeneID" id="20676080"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_450816"/>
    <dbReference type="eggNOG" id="ENOG502SDZR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_647334_0_0_1"/>
    <dbReference type="InParanoid" id="W4KCU0"/>
    <dbReference type="OrthoDB" id="3267800at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="424" mass="44974" checksum="DA7228C254B764CA" modified="2014-03-19" version="1">MHLFSSKSKPSATDTLDNAADTDVYPGGPSPDSTQFMAQNVPSVSDTYGGGSRGMIDQVDQTRITDPVDEIQPGFTADPIDEGFSGGVDVARQPSVAGAGSPLPTRHAPTDQRGFGSSSHAEPQPLTIQEESAGQAGNPRNPLANDTMTNERSGFQPFGVRDDPNAAIASLNNAYDAQNAPITESSPRSAIAPAQYDAPVSGGLARNTSISQQADGFQQASVGANNAGKTGVENASGGAFVGGAATASMAQREIDPTVQQRMSAADEGLGQKSRAKIAKEEHKHGRTLSKVIRSEAMAEKQALEVAIKQLGEIQRIQKEAVKEESQSHTMQSRALSEAHKSEMQFMAARTAHERGQAALKAAEQALEASRKHARETTEMLRDKMDEVERLRMMKQADDREGAVKMKALVGEKSGFSRLLGKSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KD02</accession>
    <name>W4KD02_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protoheme IX farnesyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_315597</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545246.1">
        <property type="nucleotide sequence ID" value="XM_009546951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KD02"/>
    <dbReference type="FunCoup" id="W4KD02">
        <property type="interactions" value="377"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KD02"/>
    <dbReference type="GeneID" id="20670237"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_315597"/>
    <dbReference type="eggNOG" id="KOG1380">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029631_3_3_1"/>
    <dbReference type="InParanoid" id="W4KD02"/>
    <dbReference type="OrthoDB" id="5211at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000004">
        <property type="entry name" value="Protoheme IX farnesyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW82946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="312" mass="33005" checksum="31245B9E77012AF3" modified="2014-03-19" version="1">MSGVALSPAPVSVPVLLATALGTALCSSSANAFNQLQEIPFDAQMARTRSRPLIRRALSPLHVAAFASLTGAAGPALLWAVVNPTTAVLGAANIALYAGAYTYMKRRTIWNTWVGAVVGAIPPLMGWAACGGALLPSSEALHTVSAALLSGGAPGDVLASIAAAADGLALAPLALGLFHFAWQFPHFNSLSYVVRGAYARGGYYMLSVLDPRRNAATALRHALLLTGVCSVLVPLSGLTTWAFALTSLVPNAVFVQASWRFWKQGGEHHARRLFHHSLWYLPVVMGLMMVHKKGMDWGKWLGLVNEEEEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KE13</accession>
    <name>W4KE13_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_102625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543716.1">
        <property type="nucleotide sequence ID" value="XM_009545421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KE13"/>
    <dbReference type="GeneID" id="20665853"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_102625"/>
    <dbReference type="HOGENOM" id="CLU_2097181_0_0_1"/>
    <dbReference type="InParanoid" id="W4KE13"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845390" description="Secreted protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW83994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="12459" checksum="B1D1BEB442C90539" modified="2014-03-19" version="1">MVHARPSLLAVLCALRAGLLAALAADLSSCRCLRPPTPARAHTRIMQSAIDVPFAPPPKHIESRPTTQLRPRPEPEQPSPSTALQTGSHHGLGPWSSDRAFTSNQLRPPNPVLLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4KE36</accession>
    <name>W4KE36_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cleft lip and palate transmembrane 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_433003</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543734.1">
        <property type="nucleotide sequence ID" value="XM_009545439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KE36"/>
    <dbReference type="STRING" id="747525.W4KE36"/>
    <dbReference type="GeneID" id="20674644"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_433003"/>
    <dbReference type="eggNOG" id="KOG2489">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019907_2_0_1"/>
    <dbReference type="InParanoid" id="W4KE36"/>
    <dbReference type="OrthoDB" id="378564at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF0">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW84014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="573" mass="65256" checksum="9B28890DF8A1B626" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEA0</accession>
    <name>W4KEA0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_316027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545637.1">
        <property type="nucleotide sequence ID" value="XM_009547342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEA0"/>
    <dbReference type="GeneID" id="20670285"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_316027"/>
    <dbReference type="HOGENOM" id="CLU_2498131_0_0_1"/>
    <dbReference type="InParanoid" id="W4KEA0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="86" mass="9257" checksum="E2C62F5864F17398" modified="2014-03-19" version="1">MPGLSGCVSNPPFGSSYRVGGPRIGTSSMKGMVVSGISGWRMWVTSSWKIGTEFVHPMGRVTSRWAPNGVWNVVKSRDDSASPRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEX6</accession>
    <name>W4KEX6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartyl aminopeptidase</fullName>
            <ecNumber evidence="4">3.4.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_63112</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.</text>
            <dbReference type="EC" id="3.4.11.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.21" evidence="4"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543285.1">
        <property type="nucleotide sequence ID" value="XM_009544990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEX6"/>
    <dbReference type="FunCoup" id="W4KEX6">
        <property type="interactions" value="321"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KEX6"/>
    <dbReference type="GeneID" id="20678627"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_63112"/>
    <dbReference type="eggNOG" id="KOG2596">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019532_2_0_1"/>
    <dbReference type="InParanoid" id="W4KEX6"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002759">
        <property type="entry name" value="PRK02813.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF3">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 11" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW84393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="474" mass="51503" checksum="3FB7706E5B30D724" modified="2014-03-19" version="1">MLYPSAPEAATKFLNFVNASPTPFHAIHNAIVRLETAGFHKVREADNWETEIKPGGKYYFTRNQCALLAFTIPQKWQAGAGVSIVATHVDSPNLRVRPVSKRTASGYLQVGVETYGGGIWHSWFDRDLSLAGRVVVAGKNAGYTTKLVKIEAPLLRIPTLAIHLDRTANDTFKFNQETEFVPVLGLLSSQLNAPKGRKSNDATKEDGMLESTSSIQANHHSVLLDTIAGELQIHPADIHDFELQLYDTQPSVLGGLNNEFIFSPRLDNLVSSFCAVEALSGVVSGNSFPTLEGNVNCIALFNHEEIGSVSSTGAESSLIPSLLERLSPSPSQLAQSIAKSFLISADMGHAINPNYPNKHEENHKPYMNGGIVIKTNAKQRYASDAIGAFIIKKLVEQKGGRVQEYEIRNDMACGSTVGPLLSKIGVRTVDVGNAMLSMHSIRETAGSRDVQHAIDLFSSFFEGFAALDAKLTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KF24</accession>
    <name>W4KF24_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_381995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544124.1">
        <property type="nucleotide sequence ID" value="XM_009545829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KF24"/>
    <dbReference type="STRING" id="747525.W4KF24"/>
    <dbReference type="GeneID" id="20672103"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_381995"/>
    <dbReference type="eggNOG" id="KOG3382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110455_2_1_1"/>
    <dbReference type="InParanoid" id="W4KF24"/>
    <dbReference type="OrthoDB" id="274641at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B17.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW84452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="138" mass="16234" checksum="328AC9187E909CAC" modified="2014-03-19" version="1">MPSLARYIRGIRQVGIKEWWHQMQYIGDVKAGIFMGKDQFGNRYFENLNGEQEVPGRHRWVDFAQHDNNATQVPAEWHAWLSHIRKEVPPEDKVMQAVSPPWKAPWIENLTGTRGAYRSYNTAKPKIETWEPKTLPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFK1</accession>
    <name>W4KFK1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_408125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543557.1">
        <property type="nucleotide sequence ID" value="XM_009545262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFK1"/>
    <dbReference type="GeneID" id="20672662"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_408125"/>
    <dbReference type="HOGENOM" id="CLU_3087495_0_0_1"/>
    <dbReference type="InParanoid" id="W4KFK1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="52" mass="5641" checksum="12B562A6E658F59A" modified="2014-03-19" version="1">MALQASNDGQLLFAGPERDERSARIGRDACDSATRGFGSQKGTRASIRSWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGT0</accession>
    <name>W4KGT0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_443395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541953.1">
        <property type="nucleotide sequence ID" value="XM_009543658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGT0"/>
    <dbReference type="GeneID" id="20675522"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_443395"/>
    <dbReference type="HOGENOM" id="CLU_1030796_0_0_1"/>
    <dbReference type="InParanoid" id="W4KGT0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="270" mass="28583" checksum="C99472739218E9CC" modified="2014-03-19" version="1">MDERSSGKQLKGLGAGTRQGGKGPDVDPVSGVTVEASRTLSSGGMRRRASRIPVQSHLESDHCSSSNSIITTNANSISSRTHTHITMLATQQPSSAFSTPYMHVPGIPIVTRRTARSAPRPMRVISFPIPPSARARRAPPLPPRIARLQAPAAAYTLTDNPFADPDAITNAAEPVSEPRARTSPAATSVHPAHARTRPSYASAARAAPVQPAPPPLPERGVRASAVACLLLHRAHARPLRRWAQAGPRAYVRSRLSSVIVAETEGGDDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4KH69</accession>
    <name>W4KH69_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_309794</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542062.1">
        <property type="nucleotide sequence ID" value="XM_009543767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KH69"/>
    <dbReference type="STRING" id="747525.W4KH69"/>
    <dbReference type="GeneID" id="20669715"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_309794"/>
    <dbReference type="eggNOG" id="ENOG502SVNT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101063_1_0_1"/>
    <dbReference type="InParanoid" id="W4KH69"/>
    <dbReference type="OrthoDB" id="3260945at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="16"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW85187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="177" mass="19755" checksum="4AE6C81AC46D330C" modified="2014-03-19" version="1" fragment="single">LSEWPDGPYEWQVKATANILDGHNQLIIAGYGNGKTAVTYLHLLFVQELFNNPDIPCSGCKLVQHGIALIISPLADLAHSQVKEMLTMGIHAVSLDKQSIKAAQVKGRNLLREVAQYKHPVVIISPERLYSPEFDRILQTDKIQEQLALCCIDEVHVVLPWSCTFCEAYAQLGHIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHB6</accession>
    <name>W4KHB6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4939 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_448412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542120.1">
        <property type="nucleotide sequence ID" value="XM_009543825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHB6"/>
    <dbReference type="GeneID" id="20675853"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_448412"/>
    <dbReference type="eggNOG" id="ENOG502S3G3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_780884_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHB6"/>
    <dbReference type="OrthoDB" id="8955945at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="40344" checksum="086ABE4DEA96B846" modified="2014-03-19" version="1">MVGRKVLRVLIKKVRGVDGTEEEDIWNEIESQWELAPQYREPVPVIPEDLEQEETTSQSDSDSSPDQTPINPRNEPLAEMSGQASTSTDPPSATVQPGRKKVKLPDNYTGNHIESQKFMLQCLLLFAAESDQYKTNQDKISLVLSCMRYGTAGAWAKNFLLKSVGADPPTDLGRMTVDEYSNQFILIAADADISDKEQVPYFQCGLDPRVMDKIYDKEVQTKDTIQDWINTACEIDGQLRARSAQKAILANSTSFRSDYLNHFHTQPAGEETAQLIWKEKTTHPLWETKREYIEEWRQRMFIATTSGYHNLVLRWNVRTLPHPDNPRRTISDASCRLTDDKGMEASVILLASEQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHC0</accession>
    <name>W4KHC0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_101123</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541999.1">
        <property type="nucleotide sequence ID" value="XM_009543704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHC0"/>
    <dbReference type="GeneID" id="20665733"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_101123"/>
    <dbReference type="eggNOG" id="ENOG502QV1E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019189_13_1_1"/>
    <dbReference type="InParanoid" id="W4KHC0"/>
    <dbReference type="OrthoDB" id="2968323at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="7">
        <location>
            <begin position="53"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW85114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="526" mass="60667" checksum="CA72D3B75779FB02" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHL1</accession>
    <name>W4KHL1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_309534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542204.1">
        <property type="nucleotide sequence ID" value="XM_009543909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHL1"/>
    <dbReference type="STRING" id="747525.W4KHL1"/>
    <dbReference type="GeneID" id="20669686"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_309534"/>
    <dbReference type="eggNOG" id="ENOG502SIZI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006410_5_0_1"/>
    <dbReference type="InParanoid" id="W4KHL1"/>
    <dbReference type="OrthoDB" id="2747778at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="148"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="701" mass="79805" checksum="76F65BBE3B5A4753" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHW4</accession>
    <name>W4KHW4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_408740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544528.1">
        <property type="nucleotide sequence ID" value="XM_009546233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHW4"/>
    <dbReference type="GeneID" id="20672709"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_408740"/>
    <dbReference type="HOGENOM" id="CLU_2146188_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHW4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW84905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="112" mass="12691" checksum="EEFF34C03F4CDC7E" modified="2014-03-19" version="1">MFRRWTISRKKAFSFAPAVPVTCNDKCGIRKALFVHVSHSLPAILGCRLKTLSLGITSDLSEDQNEELGVVEWRALYSEGKYELVTRQYGVRTRKELCVMMDGTRRAPKGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHY4</accession>
    <name>W4KHY4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_103216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544329.1">
        <property type="nucleotide sequence ID" value="XM_009546034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHY4"/>
    <dbReference type="GeneID" id="20665876"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_103216"/>
    <dbReference type="HOGENOM" id="CLU_1180349_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHY4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW84691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="235" mass="24782" checksum="DCE2AA52B4D1747B" modified="2014-03-19" version="1">MLLLAATPERRLRTSRQSSNWACLAPNEPAHASLGVACRTTRLALASLRWRLLGRAKTSRPIAATFVVGLNRRTGPALGTLRVVVGSGWLVHRMGYPAFSRTTLASWGVRLASHELSAGPSAYGTKQCPAHNPRGSSRALEATRATQGGHVADMETTQRGDAPVMPVHASAVRWQPTRVGGGPFPPRARLLPNAATTVTRRGTVLTLASPVPPRATPLGGYPICHGSGGAQKCAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIE5</accession>
    <name>W4KIE5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">26S proteasome regulatory subunit 7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_32539</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541744.1">
        <property type="nucleotide sequence ID" value="XM_009543449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIE5"/>
    <dbReference type="FunCoup" id="W4KIE5">
        <property type="interactions" value="573"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KIE5"/>
    <dbReference type="GeneID" id="20671148"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_32539"/>
    <dbReference type="eggNOG" id="KOG0729">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_6_0_1"/>
    <dbReference type="InParanoid" id="W4KIE5"/>
    <dbReference type="OrthoDB" id="1937997at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000005">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000440">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048723">
        <property type="entry name" value="OB_PRS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21236">
        <property type="entry name" value="OB_PRS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="228"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW85627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="453" mass="50350" checksum="136542830016FD2D" modified="2014-03-19" version="1">MPPKADWEKYNKKVDEKEEKIVSLDDSDIQILKTYGQGPYASQLKKIDGDIKDIQKRINEKLGVKESDTGLSSPNLWDLPADRQRMSAHAFQVARCTKIIPVDEKQAEAARAVNPAGAAQGQKGADEQDKYVINIKQIAKFVVGLGDRVAPSDIEEGMRVGVDRHKYQIMIPLPPKIDASVTLMQVEEKPDVTYSDIGGCKEQIEKLREVVETPLLSPERFVDLGIDPPKGVLLFGPPGTGKTLCARAVANRTDATFIRVIGSELVQKYVGEGARMVRELFEMARGKKACIIFFDEVDAIGGTRFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALLRPGRLDRRVEFSLPDAQGRAHILRIHSRSMSVERDIRFDLIARLCPNTTGAELRSVSTEAGMFAIRARRKVATERDFLDAVEKVVQQGTKFSSTPLYQVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIF0</accession>
    <name>W4KIF0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_309393</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NUF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542470.1">
        <property type="nucleotide sequence ID" value="XM_009544175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIF0"/>
    <dbReference type="FunCoup" id="W4KIF0">
        <property type="interactions" value="74"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KIF0"/>
    <dbReference type="GeneID" id="20669673"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_309393"/>
    <dbReference type="eggNOG" id="KOG4438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025461_1_0_1"/>
    <dbReference type="InParanoid" id="W4KIF0"/>
    <dbReference type="OrthoDB" id="8194677at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005549">
        <property type="entry name" value="Kinetochore_Nuf2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041112">
        <property type="entry name" value="Nuf2_DHR10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03800">
        <property type="entry name" value="Nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18595">
        <property type="entry name" value="Nuf2_DHR10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Nuf2 N-terminal" evidence="12">
        <location>
            <begin position="7"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Nuf2 DHR10-like" evidence="13">
        <location>
            <begin position="258"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="340"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW85632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="450" mass="51592" checksum="FAF3DE332B4209B5" modified="2014-03-19" version="1">MNKQPGYWYPSMGNQELIDCFDTWGIKLTTQQLLKPSPEFVYDVYLACILQVNGVTQQVLDERLEILLAAINEPNPDIFGNSLSQNLILYQISRLADAAKVPDFNIKDLTFPDSTRTCGILCAIANFIKFNEQCEVFISELRDGSAALVKEREIVAMELAEVRRNNAALSAKQAEDRPMCESLQQENAGLTAHLIAQKEIQGVLLKDIENLKADRESLVQRKEGLNADSAVVSDTVARTRSRIVQSPERIRRNISSMSTTAMEDKKTLGAQEAKARDLQAKISALLNIEKDVRGALEQLQTIEKEAYALELTQKEFIDTRDHLDQKKIERTELEMKYQASFRVQKQLSNAQEKLERAQQHAEDKRLAGQHTIERLQREYEEMVLDRRDNEKQVEELRSKANEFERQMAEHLRSCEAELNELLTEYWKLRHETEVYMEILANKLGMRVSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJM9</accession>
    <name>W4KJM9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_425066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542839.1">
        <property type="nucleotide sequence ID" value="XM_009544544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJM9"/>
    <dbReference type="GeneID" id="20674018"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_425066"/>
    <dbReference type="HOGENOM" id="CLU_2109354_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJM9"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="115" mass="12928" checksum="82371F3156374E0B" modified="2014-03-19" version="1">MEELEGRGWSHGSTAAERSHRRPFHEEIHHVRREGGSRKERDEAQASAEAGSHLKCIVLVKSMAHRQFRIQAIEPLLAIFSAMAVTAEDTPFHCSVEVWSPKPSMTAEEQGRRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJW8</accession>
    <name>W4KJW8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_309538</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the GSE complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542917.1">
        <property type="nucleotide sequence ID" value="XM_009544622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJW8"/>
    <dbReference type="FunCoup" id="W4KJW8">
        <property type="interactions" value="170"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KJW8"/>
    <dbReference type="GeneID" id="20669687"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_309538"/>
    <dbReference type="eggNOG" id="KOG3886">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044099_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJW8"/>
    <dbReference type="OrthoDB" id="10020193at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11384">
        <property type="entry name" value="RagA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039397">
        <property type="entry name" value="RagA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW86147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="301" mass="34030" checksum="A97F015B364289B5" modified="2014-03-19" version="1">MGASGSGKTSMRSLIFSNNPASLTSRLGATIDVEQNHVRFLGDLILNLWDCGGQDAFMDIYLSTQRSTIFQHVGVLIYVFEVESRDMAKDLVYYRDCLDALKKYSPDTSVFLLFHKMDLVSGDRVAVLDRKRRELEQESTGVAVTVFGTSIYDESLYKAWSSIVHTIVPNAAVLTRHLTMFAEMCNATEVILFERTTFLVIATSTFPVSAPRTSSLLSPTRYERTSELIKAFKHSCSRVREEFHSLEMELPDFTAVLDEMTKNTYVLIIVHDPTIETAALKINIRLARRKFEELQSDSIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJY1</accession>
    <name>W4KJY1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fructose-2,6-bisphosphate 2-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_32529</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.46" evidence="2"/>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541743.1">
        <property type="nucleotide sequence ID" value="XM_009543448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJY1"/>
    <dbReference type="FunCoup" id="W4KJY1">
        <property type="interactions" value="220"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KJY1"/>
    <dbReference type="GeneID" id="20671134"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_32529"/>
    <dbReference type="eggNOG" id="KOG0234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006383_6_1_1"/>
    <dbReference type="InParanoid" id="W4KJY1"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000005">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000644">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF44">
        <property type="entry name" value="6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="8">
        <location>
            <begin position="35"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="265"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW85635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="479" mass="54572" checksum="0FBB564FB3FA1180" modified="2014-03-19" version="1">MLKQFDESNISSRKGSQATTPPRSVVGIGGKVAKPDYSEAKIVLAMVGLPARGKSYLSNKLMRYLQWLEYDVKVFNVGQLRRSRARLKKQQSGIKEDHTASYFSHDNVEATRSRDQLAEDSLEMLIQWLKEGGNVGIHDATNSTRARRAKIEARVAKEKGIVVIFLESVCDDPALIAANVALKVSSGDPDYKDMSPEDAKQDFLRRIKQYESVYETITEPHLSYLRITNVGNQTTVCRIHGYLQSRIAFYLMNLHLKPRSIFFSRHGESQFNVEGKIGGDSYLSERGMRYATMLPALITDNIGDAPLTVWTSTLQRTIQTAHQLPYTKLTWKSLDELDAGVCDGMTYEEIEQAYPEDFANRDEDKFNYRYRGGESYRDVVVRLEPVIMELERQENILIIGHQAILRCLYAYFHNLPQADLPYIKIPLHTVIKLTPKAYGCDEERYTLPIGAVDTHRPKPKQSQIVVKPTTDREYFGDQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4KK18</accession>
    <name>W4KK18_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_407905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542968.1">
        <property type="nucleotide sequence ID" value="XM_009544673.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_407905"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2794246_0_0_1"/>
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    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW86208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="68" mass="8025" checksum="6CB3EFAED39CBB06" modified="2014-03-19" version="1">MEDELSIRTGETLRLLEQFEDEWCLVQRVGRADAEKGVIPRFCLKERPRVSPQRVTTSTFTFGQPWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KL03</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">HETIRDRAFT_449208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543111.1">
        <property type="nucleotide sequence ID" value="XM_009544816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KL03"/>
    <dbReference type="GeneID" id="20675919"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_449208"/>
    <dbReference type="eggNOG" id="ENOG502SS6N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_498790_0_0_1"/>
    <dbReference type="InParanoid" id="W4KL03"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
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        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="546" mass="58832" checksum="DE7D1249ACC6BA15" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNJ9</accession>
    <name>W4KNJ9_HETIT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_240818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540634.1">
        <property type="nucleotide sequence ID" value="XM_009542339.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNJ9"/>
    <dbReference type="STRING" id="747525.W4KNJ9"/>
    <dbReference type="GeneID" id="20668872"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_240818"/>
    <dbReference type="eggNOG" id="ENOG502S2GY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061245_1_0_1"/>
    <dbReference type="InParanoid" id="W4KNJ9"/>
    <dbReference type="OrthoDB" id="2139939at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044688">
        <property type="entry name" value="SCI-1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117:SF1">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="284" mass="32068" checksum="51EFE679DC4AC4C6" modified="2014-03-19" version="1" fragment="single">SRSQSQDRSESPEIRLPGGAAPISESDYFLKSAEFRVWLKDAKHKYFDELSGERARKYFRKFVKEWNRGKLERALYSGVDPSSPTAYSHTKYKWSFASKSSKADSQALEAARAEVGAATYGGGRVSSSSGPSGSGRVQGPTLPSPADLIIARETADEFRAAEREYKRKRDRAEAKDRVEDAVGPREVGRERLMEKKREKREGDRMFRERAEDGLEADEGTLMGGGDSFKEQIARRDAARKRFEEKRGGPREEKIAAVRERTTAIREKDKATMDMFMQMAKAKYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4KP59</accession>
    <name>W4KP59_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SGTA homodimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_469758</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SGT family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009543190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KP59"/>
    <dbReference type="FunCoup" id="W4KP59">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KP59"/>
    <dbReference type="GeneID" id="20677307"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_469758"/>
    <dbReference type="eggNOG" id="KOG0553">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044224_1_1_1"/>
    <dbReference type="InParanoid" id="W4KP59"/>
    <dbReference type="OrthoDB" id="2335338at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="Deflorio G."/>
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                <person name="Durling M."/>
                <person name="Gonthier P."/>
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                <person name="Hansson D."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Lucas S."/>
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</entry>
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            <end position="1715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1818"/>
            <end position="1832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1840"/>
            <end position="1857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1894"/>
            <end position="1905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW87819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1913" mass="209336" checksum="FE8F4EF5AA416E36" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KQB2</accession>
    <name>W4KQB2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_437805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541167.1">
        <property type="nucleotide sequence ID" value="XM_009542872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KQB2"/>
    <dbReference type="STRING" id="747525.W4KQB2"/>
    <dbReference type="GeneID" id="20674983"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_437805"/>
    <dbReference type="HOGENOM" id="CLU_1447867_0_0_1"/>
    <dbReference type="InParanoid" id="W4KQB2"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="187" mass="20376" checksum="58053924F4D125D0" modified="2014-03-19" version="1">MHAHGAIPSPDTLSRRLTALSPRVSRPSSPPGSRPDSAFAQMMLRHDPETVSPIGKISANESVEEDDTDTPPLSTESTPLDVADKLRLDVSVELETEADDKVLSPRPIKLNGASFLRPQSETEDEASEYAETSSDASEGADGVREAIRGVFRLWMTSKQKNALNYGKSNGTAGEREFLRIVREAIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4JM93</accession>
    <name>W4JM93_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_456218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553143.1">
        <property type="nucleotide sequence ID" value="XM_009554848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JM93"/>
    <dbReference type="GeneID" id="20676715"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_456218"/>
    <dbReference type="HOGENOM" id="CLU_2867927_0_0_1"/>
    <dbReference type="InParanoid" id="W4JM93"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW74648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="64" mass="6669" checksum="E407B753CBE3E660" modified="2014-03-19" version="1">MTLATPSSRAKCKYATAGMKSHLASPPTPPPSNFSSGPLLAIAAHQMSSAIRASDAFHALNMDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4JN88</accession>
    <name>W4JN88_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_331825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW75027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553478.1">
        <property type="nucleotide sequence ID" value="XM_009555183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JN88"/>
    <dbReference type="STRING" id="747525.W4JN88"/>
    <dbReference type="GeneID" id="20671684"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_331825"/>
    <dbReference type="eggNOG" id="ENOG502SNUP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031314_2_0_1"/>
    <dbReference type="InParanoid" id="W4JN88"/>
    <dbReference type="OrthoDB" id="3025143at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW75027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="25118" checksum="0BBBBEE19C2D9E34" modified="2014-03-19" version="1">MKEAAEVLESARLESEKFLKQERRSHRRGNYAALSVSPSYGGGQKKAGNLCHSDHQNRILESLLKEKSIKRIAGFASGKFPAFGSYAPKTYDFYRTTMSQLIERHPELQWNFDNSVFPTMTFNMGPDTTCLDHNVCTNVPQGFCSITALGDFNPSKGGYFYLWDLRLVIRFPPGSTILIPSSSLRHGTTPIQTGESRYSICCFWAFWLMWHPCHMGATFGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPB4</accession>
    <name>W4JPB4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_246871</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="5"/>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552735.1">
        <property type="nucleotide sequence ID" value="XM_009554440.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPB4"/>
    <dbReference type="GeneID" id="20669130"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_246871"/>
    <dbReference type="eggNOG" id="ENOG502S9FN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065200_6_0_1"/>
    <dbReference type="InParanoid" id="W4JPB4"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004843727" description="Protein-S-isoprenylcysteine O-methyltransferase" evidence="6">
        <location>
            <begin position="28"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW75304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="238" mass="25866" checksum="02C506FB4324B927" modified="2014-03-19" version="1" fragment="single">STTAMISTTTPWLKIGLLLIAAASVDASLSPPQPPVPPKQQTGPSLFNRVSLTWVLAIIDAVMTLCTVYAPTSAAAVSLCRRAPSSPTALTIPGTLFVVAVASCVAGALLRKWCYVTLGRLFTFEVSIMPKHQLVVSGPYAWIRHPSYTGLHLTLVGVTVMLGARGSWARECGMLGWGSTADVLAWWFAGFWVVKCGFAVYSTMKRVRVEDGELRKTFGPAWEEYAKRVKFALVPWVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPS7</accession>
    <name>W4JPS7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_447006</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552975.1">
        <property type="nucleotide sequence ID" value="XM_009554680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPS7"/>
    <dbReference type="GeneID" id="20675724"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_447006"/>
    <dbReference type="eggNOG" id="ENOG502RQFZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1503604_0_0_1"/>
    <dbReference type="InParanoid" id="W4JPS7"/>
    <dbReference type="OrthoDB" id="2900904at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004843815" evidence="3">
        <location>
            <begin position="21"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW75577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="219" mass="23105" checksum="2FB6CD817D21C2A1" modified="2014-03-19" version="1">MQFKYLIALSALLLSSTVIAAPLPEGTTNDVILQRRSVSPSFTFTNDLANIVIPAPLPATAAKKAIAAQEKKIKKAQANQKAKEALQKTASSHVTTVLNAAADTLKLSGSLAVKVTNDFHTSKDPESHATFEFSAPACGGTCVGHAYKSPSKISPGKGQPGKIFSAGHAVIFGGVDKPNVHLMHYRATSRSHKKATTEADDAEETTTMEGRDGLHDNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPZ3</accession>
    <name>W4JPZ3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_246936</name>
        <name evidence="1" type="ORF">HETIRDRAFT_246938</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544774.1">
        <property type="nucleotide sequence ID" value="XM_009546479.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552999.1">
        <property type="nucleotide sequence ID" value="XM_009554704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPZ3"/>
    <dbReference type="STRING" id="747525.W4JPZ3"/>
    <dbReference type="GeneID" id="20669133"/>
    <dbReference type="GeneID" id="20669134"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_246936"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_246938"/>
    <dbReference type="eggNOG" id="ENOG502SF7K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106777_0_0_1"/>
    <dbReference type="OrthoDB" id="3258143at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW75603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="16056" checksum="7521DA5CF6BD0974" modified="2014-03-19" version="1" fragment="single">KTELMHFPRRGNTSQLPTITLAGRTIEPSTTWRYLGFIFDPRLSFKEHVRFYATRALSTVKCALRLGNSLRGLSPLQRRTLYKSCVVPLLTYGCRVWWRKHGVKGLMNILSKAQHEGVRWILSAFRTSPIGGMEVLSGIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQ62</accession>
    <name>W4JQ62_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex protein EXO70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_390036</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Bud</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EXO70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551938.1">
        <property type="nucleotide sequence ID" value="XM_009553643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQ62"/>
    <dbReference type="FunCoup" id="W4JQ62">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JQ62"/>
    <dbReference type="GeneID" id="20672436"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_390036"/>
    <dbReference type="eggNOG" id="KOG2344">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010236_4_3_1"/>
    <dbReference type="InParanoid" id="W4JQ62"/>
    <dbReference type="OrthoDB" id="1922221at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004140">
        <property type="entry name" value="Exo70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542:SF41">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542">
        <property type="entry name" value="EXOCYST COMPLEX PROTEIN EXO70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" value="Exo70_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="5">
        <location>
            <begin position="246"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW75673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="608" mass="67835" checksum="9CC237035C969D51" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQW2</accession>
    <name>W4JQW2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_67639</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552519.1">
        <property type="nucleotide sequence ID" value="XM_009554224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQW2"/>
    <dbReference type="GeneID" id="20678818"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_67639"/>
    <dbReference type="eggNOG" id="KOG0759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_14_1_1"/>
    <dbReference type="InParanoid" id="W4JQW2"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00784">
        <property type="entry name" value="MTUNCOUPLING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="18"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="111"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="210"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW75475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="305" mass="32931" checksum="49A4AED0F3D0CF37" modified="2014-03-19" version="1">MSSPTQSAALPAPAASKKQQPYPFWLGGVAATIAASITHPLDLTKVRLQASGDKRMVESIRKTVRTAGVRGLFDGISGTWMRQMSYSLCRFWAYDESKKLLGAGPGAPAWKLAAAGSMAGGIAGLVGNPGGKHMSGPVRLQGDFAKAPEKRFNYKHCFDALFRMVREEGVGSLARGVGPNVFRAVLMNASQLASYDFFKSELLKSGHFQDNIYCHFTASFAAGTVATTVCSPADVLKSRIMNASGPGSNSTMQVIRQSLRTEGAMFMFKGWLPAWTRLQPTTILIFLTLEQLKNAVDVVRGTERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQZ0</accession>
    <name>W4JQZ0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_423003</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552714.1">
        <property type="nucleotide sequence ID" value="XM_009554419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQZ0"/>
    <dbReference type="GeneID" id="20673861"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_423003"/>
    <dbReference type="HOGENOM" id="CLU_027888_0_0_1"/>
    <dbReference type="InParanoid" id="W4JQZ0"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="363"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW75281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="450" mass="48742" checksum="4DD102A9B86B4E11" modified="2014-03-19" version="1">MSSSDGPFAEWYDIIVWGCDWLSSQIPPEVSTSAATIPQSPTAIVENVTSPVLPATDSKDKPVEDMPHPSTELPVTTTLFTFANASQRPDEISSLRATIPVPLPSTLGCTEVAPDPPSTPATAFPLLFKESDAVSRIAGTKRKADETSENCGRPKSSILEVMREAERIHPLAQPQAGPSRLIEAYEDSEGIALKPHNHTTGASSFKKDFQAADSAPVNVQLWSQGPFPTQTSLVGQPTAFSASTLSQTSTLPSSPSSGSSASYAAQQSFHVGQMTFPSIPMPTSADTTRHINGPMYGVQGMTFTAPLVSHPAPSTSYSATLSIPSVSMVSITLEMLLVARERAHLLPPIPIRYGQTPYNSGSFNCHICILGFRTKRELTTHERRQTHTKRVLVLNGYTVLPPKDFPCDYPECDKEYSNRSSLVTHRRTAHGIGERIDAMAGEGRAKRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4JR42</accession>
    <name>W4JR42_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_455976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552766.1">
        <property type="nucleotide sequence ID" value="XM_009554471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JR42"/>
    <dbReference type="GeneID" id="20676684"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_455976"/>
    <dbReference type="eggNOG" id="ENOG502S8W5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_9_3_1"/>
    <dbReference type="InParanoid" id="W4JR42"/>
    <dbReference type="OrthoDB" id="184880at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW75336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="35097" checksum="0D18F2ECF8B3B920" modified="2014-03-19" version="1">MTHAERVYHSVPSSPYCLPSDEAERQRLIRQHFALKKIAGHGELLVSPLEIPEGAFVLDSGTGSGVWALDFSKQVSLSVTIYAIDIETRLFPSERPPNVIFNAGSVLRLSPSWTAKFSLIHQRLLLYALRLPDWVTALSEMFRCTKPGGTVQLTEVITPPNSSAGPCNRKWFAVLESFCASRGLVLHCARILPDLLKAAGFKDITTYETGVILGSKGGDAGMEVRRSRIGAFRGMKLPILNAGGFGVISSGDAFDELLDGVEREWEETGLAEAGYIHIVARHPLDAVASPNNAVRDLALPVLSSFHAIIRAALYNLAGYDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRA8</accession>
    <name>W4JRA8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dynein heavy chain hydrolytic ATP-binding dynein motor region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_162867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552326.1">
        <property type="nucleotide sequence ID" value="XM_009554031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRA8"/>
    <dbReference type="STRING" id="747525.W4JRA8"/>
    <dbReference type="GeneID" id="20667799"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_162867"/>
    <dbReference type="eggNOG" id="KOG3595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2590066_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRA8"/>
    <dbReference type="OrthoDB" id="2506608at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain hydrolytic ATP-binding dynein motor region" evidence="2">
        <location>
            <begin position="14"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW76107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="80" mass="9041" checksum="D0C5E4D1A5F44F9B" modified="2014-03-19" version="1">MSFWCIYNLTLSLSMAMTRPDHELIAQVTLFSQGFRTAESLASKIVPFFKIWDKQLSPHPHYGFGLRALKAVLISAGILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRJ9</accession>
    <name>W4JRJ9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_456090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552906.1">
        <property type="nucleotide sequence ID" value="XM_009554611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRJ9"/>
    <dbReference type="GeneID" id="20676694"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_456090"/>
    <dbReference type="HOGENOM" id="CLU_096172_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRJ9"/>
    <dbReference type="OrthoDB" id="446925at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="204" mass="23046" checksum="8F23647336976AF3" modified="2014-03-19" version="1">MRKDFPFVFGPDQIAAQDDLWSALLESPALWLIDYGLAANVILTIDTSQIAVGFHLCQCALNNSRVWYYAQFSSITLHDRKSQFSQPKLELYGLFCALQSLKMYLIGVRNLIVEVDARYIKGMLTNLDLEPSASINCFLHQINNMFPTTNSTSTTAIFTSSLIGDLPTDADSDDEGPTIDYSDIPRLQKALEVEKCLWLVRDWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRK7</accession>
    <name>W4JRK7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_412317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552384.1">
        <property type="nucleotide sequence ID" value="XM_009554089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRK7"/>
    <dbReference type="STRING" id="747525.W4JRK7"/>
    <dbReference type="GeneID" id="20673015"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_412317"/>
    <dbReference type="HOGENOM" id="CLU_046025_16_2_1"/>
    <dbReference type="InParanoid" id="W4JRK7"/>
    <dbReference type="OrthoDB" id="3223377at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="144" mass="16206" checksum="9A505FE606832146" modified="2014-03-19" version="1">MVAAGNSSTSIDAPVPSGVLLLIGPVLIGGFFSWLLYGILIVQIYLYYITYTRDRILIKITVYGLFLVETFQSGIVVQMAWKWMVAGWGRQVALVEPGWAYNFIPITTAVVSLWVQSFYTWRIYALGKGLLVWKIIVSFITAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4JS25</accession>
    <name>W4JS25_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_106543</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552138.1">
        <property type="nucleotide sequence ID" value="XM_009553843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JS25"/>
    <dbReference type="STRING" id="747525.W4JS25"/>
    <dbReference type="GeneID" id="20666171"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_106543"/>
    <dbReference type="eggNOG" id="ENOG502SVXW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_172736_0_0_1"/>
    <dbReference type="InParanoid" id="W4JS25"/>
    <dbReference type="OrthoDB" id="2094445at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021278">
        <property type="entry name" value="ATP19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11022">
        <property type="entry name" value="ATP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW75900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="84" mass="8898" checksum="CA6BA3E24B52B302" modified="2014-03-19" version="1">MLTTLRGCSYSVVLGRAVKTEFLALGTLVGTAALSYAAASGGSKEAPKTSLQEVKDAVKIDSSSKEEEDFIKTFIAEAEKESKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSD9</accession>
    <name>W4JSD9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_118789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551379.1">
        <property type="nucleotide sequence ID" value="XM_009553084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSD9"/>
    <dbReference type="GeneID" id="20666608"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_118789"/>
    <dbReference type="HOGENOM" id="CLU_824012_0_0_1"/>
    <dbReference type="InParanoid" id="W4JSD9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="337" mass="38749" checksum="D35B140E5B550930" modified="2014-03-19" version="1">MSQQRSQHFDAIIQQLDAPTSNVRKMVDYLLGNKWELIDAATANALMYQLPFFETFFRDYIFSNRFDTQDRYGGLRGRLHDLFDGATIKEIQVWLKKRDSTASKARALAIFSCRIINANRNPRQLITWMLEKGNTQQLNGFTNNALNSLSGLMNEFLWKYSSKRIQRTPFKAMAELPDITPNYCTDLFKPMISGPLPPYMESRSRQVSAYAANGRKTQMVGYIGQIGLVFGCFKLQVPRPKLRRKSRHCFGKNYIEGFMNTLEATSHIQPLSGAHGFEMKQNVVLARDKRKKQMGEFRERPRSKTRASVPISLEQSSRFRDSLISVSSSRSEALELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSQ5</accession>
    <name>W4JSQ5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ASX DEUBAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_239662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009553088.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSQ5"/>
    <dbReference type="STRING" id="747525.W4JSQ5"/>
    <dbReference type="GeneID" id="20668833"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_239662"/>
    <dbReference type="eggNOG" id="ENOG502SJPC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_758690_0_0_1"/>
    <dbReference type="InParanoid" id="W4JSQ5"/>
    <dbReference type="OrthoDB" id="2289918at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028020">
        <property type="entry name" value="ASX_DEUBAD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13919">
        <property type="entry name" value="ASXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASX DEUBAD" evidence="2">
        <location>
            <begin position="40"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW76489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="373" mass="41447" checksum="59A26CC754BDF8BC" modified="2014-03-19" version="1" fragment="single">TRIPSTTTKSVDTRPRHAATRNGRTKAAPADKAKAGGSGKAKASDPAEKLRVLLHEPKSALTKLDMSDVINADTWNALSSASHARLVSLFPPTAFRGFQLSLDPTHPFRRWQDEQHVRTPPSSRPPSPSFPSRLQDLDLGCFKDGHFLSAMQTFQDHLYTGWMTDAHKEMVEFYKSGIENGTLHASWKDEAWEGDELDEEDVVAAAPAAARAQMPASKVRTGAPKELRLLDLVKRHIVQAGDVLVYRRHFVQAGITIEKDVLIEVVRPKSLVVLLPSGTTSSLPAHILAHGSDMNVDGESLRSAEITSPSHLESTILDLDGRVERGQRPNSNAWKSLVVWRWREDGFEAGEKRGGREKRNTLFYLRSCSYYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSU6</accession>
    <name>W4JSU6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_455132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551500.1">
        <property type="nucleotide sequence ID" value="XM_009553205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSU6"/>
    <dbReference type="GeneID" id="20676591"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_455132"/>
    <dbReference type="HOGENOM" id="CLU_121528_0_0_1"/>
    <dbReference type="InParanoid" id="W4JSU6"/>
    <dbReference type="OrthoDB" id="3266090at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="188" mass="22113" checksum="186C34675B796D14" modified="2014-03-19" version="1">MLISRASVPDIEVEDLSAYTEEVEQNADGKSVLTRRAILAREQEMREWIKQYPPMQQLPAKLDAEITHTGALLSFGFGITYEHLLAYAAKRNIRASWAPDEAITSPVVAWGRITRLFRERIPGFLVYYRRPFSVHYDGLLALYSNHSMRELQRRVEGHEKRVIEFLQKEMELDSTPMWYWDMDYTSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTP2</accession>
    <name>W4JTP2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_480960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551678.1">
        <property type="nucleotide sequence ID" value="XM_009553383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTP2"/>
    <dbReference type="STRING" id="747525.W4JTP2"/>
    <dbReference type="GeneID" id="20677946"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_480960"/>
    <dbReference type="eggNOG" id="KOG2531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016149_6_0_1"/>
    <dbReference type="InParanoid" id="W4JTP2"/>
    <dbReference type="OrthoDB" id="1728974at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:D-xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005997">
        <property type="term" value="P:xylulose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF57">
        <property type="entry name" value="XYLULOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="669"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="669"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="682"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW76809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="768" mass="81485" checksum="AD8821C5E166DAC4" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4JU06</accession>
    <name>W4JU06_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_454450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550592.1">
        <property type="nucleotide sequence ID" value="XM_009552297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JU06"/>
    <dbReference type="GeneID" id="20676515"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_454450"/>
    <dbReference type="HOGENOM" id="CLU_657311_0_0_1"/>
    <dbReference type="InParanoid" id="W4JU06"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844070" description="Proteophosphoglycan ppg4" evidence="3">
        <location>
            <begin position="21"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW77038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="42708" checksum="1D5FA7768B458F2D" modified="2014-03-19" version="1">MPASQRLALIVLAAALAVGAAPYSLSPGRPPYVGILPARRRDLLAPLTHGNDPSSPKHVAGIGLKRQADPVFPHTVQLVNIAPSALAFPVPSHPGHLGPVTVSLSPSEHLSATSTAAHHPAPTHLDSAPGALSSSSQPTDSLPSYGAPAPTDTLMAPGSKGSFFEPPLTPHDKVKVAVVAAVLSIIVGLIACVAIAKLTSNALRKHGRRYAQFGARWPGEESVPKGSAAGAGFVSSDGSMSFVAGKSGLTSPAGSLSSIGSGTLTPPLTSLDLLTAFPSPPPSAVPSFPLPAVPAPHVSPLSTALLHTPVTQQLTLEPFRASFASDTTESTSPSLSRNTTAASEVAVRGGHRRMRSAPVSIAVSAAPSRAPSAALTVVGEEGFWDLESLYPDTRPVSASTSRRSRTRSVEVISVSSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
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    <name>W4JU57_HETIT</name>
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        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">HETIRDRAFT_411438</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JU57"/>
    <dbReference type="GeneID" id="20672951"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_411438"/>
    <dbReference type="HOGENOM" id="CLU_1787094_0_0_1"/>
    <dbReference type="InParanoid" id="W4JU57"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="142" mass="15681" checksum="91F4F637F152FBD0" modified="2014-03-19" version="1">MPTCEPLVTPSSPIPHSSRCGAPCVSLYRMVQSSTWVASANSKVSARRWSVDESWIGQELGVSWAASEDMVRVLIKVNAPHALQTTVYAFYLADNSSAMEDDERMRNKGGKDSAKTRVDQPHKFHRFLIILSGTIRSAIATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUB3</accession>
    <name>W4JUB3_HETIT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_240613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUB3"/>
    <dbReference type="GeneID" id="20668862"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_240613"/>
    <dbReference type="eggNOG" id="ENOG502SHSB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006344_12_2_1"/>
    <dbReference type="InParanoid" id="W4JUB3"/>
    <dbReference type="OrthoDB" id="3252362at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW77054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="129" mass="14874" checksum="F01FA34BFFDDA360" modified="2014-03-19" version="1" fragment="single">FSNGISTLSCVTGTKHKHICHTLLGLIIDLPLHNGYSLAHLVQSIHALLDFIYMAQFPLHTTQTLQYINKALKHFNIPKIHSLHYYTSYIKLFGTPDNYDIAYSEQLHINFTKDAYHANNKKNEYPQMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUV0</accession>
    <name>W4JUV0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_147917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550842.1">
        <property type="nucleotide sequence ID" value="XM_009552547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUV0"/>
    <dbReference type="GeneID" id="20667241"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_147917"/>
    <dbReference type="eggNOG" id="ENOG502T17R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1190046_0_0_1"/>
    <dbReference type="InParanoid" id="W4JUV0"/>
    <dbReference type="OrthoDB" id="3269227at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="233" mass="25105" checksum="4FE7FEEAD86D267A" modified="2014-03-19" version="1">MFKLIRRISSSIYPRPDRPWSDDATSIAPTIGKKRRMSDEDGDESIRGEGSTRKRRGQLDRESTVASDFGEMSAKGKETDPGVKEVTRGVNEVELEDENKTSEERPSIDSSADDPVLVKDMEEVREDTEAGPTGEQVAEGSPSIKDEGAVTKSEEESVTKEAAVVAEGSDSKDTSVRSETSILPSTSSSTSDPQDATGTSSDEIANIVENDDTSTKEIAGKEEDKDNEGLAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4JW00</accession>
    <name>W4JW00_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_453867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549762.1">
        <property type="nucleotide sequence ID" value="XM_009551467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JW00"/>
    <dbReference type="STRING" id="747525.W4JW00"/>
    <dbReference type="GeneID" id="20676441"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_453867"/>
    <dbReference type="eggNOG" id="ENOG502SSWX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1069819_0_0_1"/>
    <dbReference type="InParanoid" id="W4JW00"/>
    <dbReference type="OrthoDB" id="3265169at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="137"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW77727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="260" mass="27774" checksum="12269E66911C6432" modified="2014-03-19" version="1">MSSHKSYAASNTTYVPTPHWSPNNLTGTTLTSGLPAVPYQQSAANNETGYRGPYPGSVGLTSASPASSTGSPRSLESYATAYSMSVPSTPGAPYMHTVPLPLVSGSYGLPTPPNSPQTRPHPKLDQTLTYNTHSPYNFDVSYAPSGDLLALRQSALQPATARMVLTVPGIWTFEAANPRGVTVADVISAISQHLCARATGHEPEYHSRAGQPDVVRAYARRTAHARGDGLRRVDLLMSHTRFAGLSRARDGSDSWIVHFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWC5</accession>
    <name>W4JWC5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="10">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HETIRDRAFT_37241</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10 13">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="10"/>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550470.1">
        <property type="nucleotide sequence ID" value="XM_009552175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWC5"/>
    <dbReference type="FunCoup" id="W4JWC5">
        <property type="interactions" value="467"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JWC5"/>
    <dbReference type="GeneID" id="20671848"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_37241"/>
    <dbReference type="eggNOG" id="KOG1526">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023296_1_0_1"/>
    <dbReference type="InParanoid" id="W4JWC5"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000016">
        <property type="entry name" value="Isocitrate dehydrogenase [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 14" id="KW-0521">NADP</keyword>
    <keyword evidence="7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="1"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="58"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="77"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="292"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETW77385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="398" mass="44547" checksum="B5B6F21C95954A22" modified="2014-03-19" version="1">MTRIIWKKIREELILPYLQLDIKYFDLGLEARDATNDQITIDSANAILEHKVGIKCATITPDEARVEEFKLKQMWRSPNGTIRNILGGTVFREPIILERIPRPIPGWVNPIVIGRHAFGDQYRSTDFVAPGPGKLQLVYTPADGAAPTTLDVYDFQGRGVAMAMYNTDESITGFAHSSFKMALAKKMPLFMSTKNTILKKYDGRFKDIFQEIYESQYKPQFEAAGIYYEHRLIDDMVAQAIKSSGGFVWATKNYDGDVQSDILAQGFGSLGMMTSELITPDGQVIESEAAHGTVTRHYREYQKGNETSTNPVASIFAWTRGLLHRAKLDANPELAAFARDLEAACVEVIDADGVMTKDLALAIHGKAMRREHWVVTDVYMDAVKAKLDQKLAARAEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWM4</accession>
    <name>W4JWM4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_479129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_479129"/>
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    <dbReference type="OrthoDB" id="3220023at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="642" mass="72464" checksum="14FE2906161D704A" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXG1</accession>
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            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_244466"/>
    <dbReference type="HOGENOM" id="CLU_001305_3_0_1"/>
    <dbReference type="InParanoid" id="W4JXG1"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW77576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="60" mass="6982" checksum="C98A75006B95CFC3" modified="2014-03-19" version="1" fragment="single">DDDGPKIANEFYRRDFNDHADGSAPDTTESARALHITVKKLRAQYNERSFVRWVPFVHYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550429.1">
        <property type="nucleotide sequence ID" value="XM_009552134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JY06"/>
    <dbReference type="STRING" id="747525.W4JY06"/>
    <dbReference type="GeneID" id="20668906"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_241856"/>
    <dbReference type="eggNOG" id="KOG4161">
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    </dbReference>
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    <dbReference type="InParanoid" id="W4JY06"/>
    <dbReference type="OrthoDB" id="10265068at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA_glycosylase"/>
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        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045138">
        <property type="entry name" value="MeCP2/MBD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074:SF0">
        <property type="entry name" value="METHYL-CPG-BINDING DOMAIN PROTEIN 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074">
        <property type="entry name" value="METHYL-CPG-BINDING PROTEIN"/>
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    </dbReference>
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        <location>
            <begin position="17"/>
            <end position="132"/>
        </location>
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            <begin position="102"/>
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        </location>
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        </location>
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    </feature>
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            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW78462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="198" mass="22176" checksum="4CE195EB4B8F41F5" modified="2014-03-19" version="1" fragment="single">KEHLASDMWRMLVAVTLLNKTAGTHALPIFWHLMDKWPSPSALARADVTEVVDAIRSLGLQATRGARLVAMSRAYLFRAPPAAVAPEPARAVCRSKYYPVDAPERPSESAPGKQQRRARRPITPISGLPGSGQYAEDSYRIFCAGEDEWRRVVPKDKELVRFIKWRWAVEGQRWSPDGDGRANGPATQDYLEALIQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W4JY28</accession>
    <name>W4JY28_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_388085</name>
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        <lineage>
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            <taxon>Agaricomycotina</taxon>
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            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550010.1">
        <property type="nucleotide sequence ID" value="XM_009551715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JY28"/>
    <dbReference type="FunCoup" id="W4JY28">
        <property type="interactions" value="374"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JY28"/>
    <dbReference type="GeneID" id="20672347"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_388085"/>
    <dbReference type="eggNOG" id="KOG1985">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004589_2_1_1"/>
    <dbReference type="InParanoid" id="W4JY28"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01479">
        <property type="entry name" value="Sec24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
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    </dbReference>
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        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Severin"/>
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    </dbReference>
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        <property type="entry name" value="von Willebrand factor, type A domain"/>
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    </dbReference>
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        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
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        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="WW" evidence="13">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="29"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="184"/>
            <end position="218"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW78005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="945" mass="103045" checksum="10891A5BB5C06A43" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYI6</accession>
    <name>W4JYI6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_324082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009550642.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="20671019"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_324082"/>
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    <dbReference type="OrthoDB" id="2744793at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
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        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="340" mass="38359" checksum="EECE0FABBF230426" modified="2014-03-19" version="1">MNVSESPKIVQHAGTVLLGNILELVIISFFSGIYTILMLCLIYLFYQGKVISRAKSYMFAITLLTFFTIAIICLYDIIDVIQTIPNLLILAENQTLENKFSKINQDIKIYNTINLSLQIVNALLGNTVIVWRAQTLWANHYIMVLLKGILIVTIIASISNCVLNSIGSIAIFDLLDYYSLYLQMIQWGLEIIMNSVVTILIAYKAWSYRQSVKTYLAKNKKTQIENILALLVESGILYCALWIALIISEFTSINGLEIDIFSSISMVFTGIYPTLIMIVVSLNSTVEEMSGISISTIHTSIQQELENTNIPAEAEVFHLQTFYEHNIVPNAEIIEETQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZT5</accession>
    <name>W4JZT5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_435327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548929.1">
        <property type="nucleotide sequence ID" value="XM_009550634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZT5"/>
    <dbReference type="GeneID" id="20674821"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_435327"/>
    <dbReference type="HOGENOM" id="CLU_2236941_0_0_1"/>
    <dbReference type="InParanoid" id="W4JZT5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="105" mass="12060" checksum="DC592CAC94881721" modified="2014-03-19" version="1">MKIIVQLHATLTVSSLIPWVRRYSIATIECFFCNVQRTPERLMNCASGALASTESLALTNWRLSWGLETLKEHSLIFPDVLEECFKQRSDQCSVLKEQCRPIVRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W4K034</accession>
    <name>W4K034_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HETIRDRAFT_64508</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548820.1">
        <property type="nucleotide sequence ID" value="XM_009550525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K034"/>
    <dbReference type="FunCoup" id="W4K034">
        <property type="interactions" value="396"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K034"/>
    <dbReference type="GeneID" id="20678683"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_64508"/>
    <dbReference type="eggNOG" id="KOG0578">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_26_6_1"/>
    <dbReference type="InParanoid" id="W4K034"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000011">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000385">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="15">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="301"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="111"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETW79183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="576" mass="62492" checksum="C93D3C26960B475C" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0Q9</accession>
    <name>W4K0Q9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_441292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549529.1">
        <property type="nucleotide sequence ID" value="XM_009551234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0Q9"/>
    <dbReference type="GeneID" id="20675346"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_441292"/>
    <dbReference type="HOGENOM" id="CLU_2705101_0_0_1"/>
    <dbReference type="InParanoid" id="W4K0Q9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="73" mass="7831" checksum="7034063046D2C18A" modified="2014-03-19" version="1">MTVTMSMSSTLSKVYPASFRAACRRCRGIRGNAACRNPRGDVKDATLDDSDFGEFEVGDVVAEVEVAPELDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4K119</accession>
    <name>W4K119_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_419216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548090.1">
        <property type="nucleotide sequence ID" value="XM_009549795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K119"/>
    <dbReference type="GeneID" id="20673545"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_419216"/>
    <dbReference type="eggNOG" id="ENOG502SQ8R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112288_0_0_1"/>
    <dbReference type="InParanoid" id="W4K119"/>
    <dbReference type="OrthoDB" id="3133596at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="235" mass="27117" checksum="36F9E1886C445302" modified="2014-03-19" version="1">MAASIWKNIECKSSSCNSPNKKWPRAGPSNHVPAEPNETENCLITRDLAADFPVYLCHVFHERYWSNHPMLSRLEWAWGMKYDTIKMDVDSNMISLRHDWRDLFESDRWALMPSMDIIEKLWDRWDKFPLHEGNVPSIEDMYDGAEIFEYRLVPVFPNVPPVSRCNGAEHISGGNRDDTVGATVYSYPFDTLPPIFSRVKPHFVVLNAGRKLDMISYKCCTTTPAMARIYGVPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1D3</accession>
    <name>W4K1D3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Monothiol glutaredoxin-5, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_147435</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549411.1">
        <property type="nucleotide sequence ID" value="XM_009551116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1D3"/>
    <dbReference type="FunCoup" id="W4K1D3">
        <property type="interactions" value="284"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K1D3"/>
    <dbReference type="GeneID" id="20667201"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_147435"/>
    <dbReference type="eggNOG" id="KOG0911">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026126_2_0_1"/>
    <dbReference type="InParanoid" id="W4K1D3"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000005">
        <property type="entry name" value="Glutaredoxin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00365">
        <property type="entry name" value="Grx4 family monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF16">
        <property type="entry name" value="GLUTAREDOXIN-RELATED PROTEIN 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="7">
        <location>
            <begin position="53"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW79150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="161" mass="17735" checksum="73EED03360997872" modified="2014-03-19" version="1">MMFRSAFRSPLVSFARTAPMTVSRAPSSLLFRRMLSDEARMQIQKAVDSSPLVLFMKGTPAAPQCGFSRAVIQVLDLHGVPPEKMQTYNVLEDSELRSGIKDFSDWPTVPQLYVKSEFIGGCDIVLGMHQSGELEELLQKNDVIPKSSESEAEPSAQPASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1F9</accession>
    <name>W4K1F9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Beta-galactosidase</fullName>
            <ecNumber evidence="3 8">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_452773</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3 8"/>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548227.1">
        <property type="nucleotide sequence ID" value="XM_009549932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1F9"/>
    <dbReference type="GeneID" id="20676296"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_452773"/>
    <dbReference type="eggNOG" id="KOG0496">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3465">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005732_2_0_1"/>
    <dbReference type="InParanoid" id="W4K1F9"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Unplaced genomic scaffold supercont1.11, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039432">
        <property type="entry name" value="SRP9_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05486">
        <property type="entry name" value="SRP9-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844250" description="Beta-galactosidase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase" evidence="11">
        <location>
            <begin position="382"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW79663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1123" mass="122317" checksum="19DD82AA80284D3F" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1R5</accession>
    <name>W4K1R5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="3">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_460037</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="3"/>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549309.1">
        <property type="nucleotide sequence ID" value="XM_009551014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1R5"/>
    <dbReference type="FunCoup" id="W4K1R5">
        <property type="interactions" value="368"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K1R5"/>
    <dbReference type="GeneID" id="20677039"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_460037"/>
    <dbReference type="eggNOG" id="KOG2835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045637_0_0_1"/>
    <dbReference type="InParanoid" id="W4K1R5"/>
    <dbReference type="OrthoDB" id="9991235at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01414">
        <property type="entry name" value="SAICAR_synt_Sc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000015">
        <property type="entry name" value="Phosphoribosylaminoimidazole-succinocarboxamide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010568">
        <property type="entry name" value="PRK13961.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR synthetase/ADE2 N-terminal" evidence="10">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="SAICAR synthetase/ADE2 N-terminal" evidence="10">
        <location>
            <begin position="74"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW79036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="331" mass="36424" checksum="482D1869A6578DBD" modified="2014-03-19" version="1">MSALIASDLSGLTLVSKGKVRDIYATSSPDHLLFVASDRISAYDVILNNVRSPGSFPPNEVQQLCSSRPRARLQGIPDKGKLLTQISLFWFGRLRETIPHHVVTANIDEMPEEVRKYKDQLEGRTMLVKKAKVVPLEAIVRGYITGSAWSEYQKSGTVHGLPLPAGLKESEKLPAPLFTPSTKADQGEHDENISPDQAAKLVGQELCDRISAVAIQLYTEAARYALSRGLILADTKFEFGLVPSPTGARDELILIDEALTPDSSRYWPASGYAPGGPQPSFDKQYLRDWLKEQGFKKGLEAGKDGQGWTMSEGVVRGTRERYVEAREKLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2V0</accession>
    <name>W4K2V0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_410574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548659.1">
        <property type="nucleotide sequence ID" value="XM_009550364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2V0"/>
    <dbReference type="STRING" id="747525.W4K2V0"/>
    <dbReference type="GeneID" id="20672879"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_410574"/>
    <dbReference type="eggNOG" id="ENOG502SK1X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019184_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2V0"/>
    <dbReference type="OrthoDB" id="2685413at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW80142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="582" mass="64896" checksum="0610523BD646A3DA" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2Z0</accession>
    <name>W4K2Z0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_321761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548013.1">
        <property type="nucleotide sequence ID" value="XM_009549718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2Z0"/>
    <dbReference type="GeneID" id="20670784"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_321761"/>
    <dbReference type="eggNOG" id="ENOG502RQWH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142978_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2Z0"/>
    <dbReference type="OrthoDB" id="3260301at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="131" mass="14375" checksum="C229CFB0A10D4F21" modified="2014-03-19" version="1" fragment="single">RTYFIRTNRAINLLITYALNTCKLPCTLRITISSSPVISSIHYIHRVFAVTTLITFMALHESLAYAAFFFILVRLYSCSFMSTLNSRSIVRQQLNGRDDEVVTVSKFAAAEAQASQLGDQAVGGFAGGVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2Z2</accession>
    <name>W4K2Z2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">cla4</name>
        <name evidence="15" type="ORF">HETIRDRAFT_63792</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547970.1">
        <property type="nucleotide sequence ID" value="XM_009549675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2Z2"/>
    <dbReference type="FunCoup" id="W4K2Z2">
        <property type="interactions" value="276"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K2Z2"/>
    <dbReference type="GeneID" id="20678654"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_63792"/>
    <dbReference type="eggNOG" id="KOG0578">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_26_6_1"/>
    <dbReference type="InParanoid" id="W4K2Z2"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13279">
        <property type="entry name" value="PH_Cla4_Ste20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000139">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000705">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="80"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="14">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="391"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="242"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="256"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETW79720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="665" mass="72376" checksum="A5B4A676BBF35DFA" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3H6</accession>
    <name>W4K3H6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_243514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009548828.1"/>
    </dbReference>
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    <dbReference type="STRING" id="747525.W4K3H6"/>
    <dbReference type="GeneID" id="20668989"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_243514"/>
    <dbReference type="eggNOG" id="ENOG502S879">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107716_0_2_1"/>
    <dbReference type="InParanoid" id="W4K3H6"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF50">
        <property type="entry name" value="REDUCTASE (ARC2), PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13400)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="31"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="129" mass="13844" checksum="341E83C59BA76CE8" modified="2014-03-19" version="1" fragment="single">PAWALDFPEPKATPPKISQEELAELVRTKTAGVDYLVVDVRRSDVEALIKGAINVPAQTFYQTLPTLLHLLAPIPAVIFHCQSSLGRGPRCAGWYADALPPGAASRALVLDGGIKAWLARWAGDADMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3V1</accession>
    <name>W4K3V1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_49574</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547955.1">
        <property type="nucleotide sequence ID" value="XM_009549660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3V1"/>
    <dbReference type="STRING" id="747525.W4K3V1"/>
    <dbReference type="GeneID" id="20678113"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_49574"/>
    <dbReference type="eggNOG" id="KOG0305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014831_5_0_1"/>
    <dbReference type="InParanoid" id="W4K3V1"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="129"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW80020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="348" mass="38063" checksum="415641A82D4D203B" modified="2014-03-19" version="1">MLGATWPVSWSQTNILVFGRGNRVNIKNLATNADIVGLAKVKDHHGFLRLLDCGGEDNPHTMALSTSKGLVQVWDLAAQKMTTSWWTKPATAMKWNGPVLTVGGEKGSIRHFDTRIKETAKMKEQNKKVLRHQSMISALAWHHEGKILASADNGGTVYCWDARQNAPLDVGDLIQRRRKMQHVGAVKGLAWCPWSSLKMLATGDAAPNGTGTIRLWNVTGSTSQNPNPDVLELDARITSLHWSTQCKELLSTHSTGKALDATTSVATPTSSQSSGMANCVAVHSYPTLARVKTEYPATSAIAGSVMSPNGLKIIFAVPEDKQLKVWDVWGKKKELRRQRSVVEPNGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4K536</accession>
    <name>W4K536_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_233247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547553.1">
        <property type="nucleotide sequence ID" value="XM_009549258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K536"/>
    <dbReference type="GeneID" id="20668728"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_233247"/>
    <dbReference type="HOGENOM" id="CLU_2518626_0_0_1"/>
    <dbReference type="InParanoid" id="W4K536"/>
    <dbReference type="OrthoDB" id="3036013at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW80854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="9989" checksum="E9E93DD2BB382E8C" modified="2014-03-19" version="1" fragment="single">MPNQYKPLPPEDELEPWIKLYYHLGLTDTQIAELTLENFDREVFGLGTKMVQCLRKKWGLKSTRQQAHTIETIAVHVAEIKRHFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5C9</accession>
    <name>W4K5C9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_123277</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547638.1">
        <property type="nucleotide sequence ID" value="XM_009549343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5C9"/>
    <dbReference type="STRING" id="747525.W4K5C9"/>
    <dbReference type="GeneID" id="20666817"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_123277"/>
    <dbReference type="eggNOG" id="KOG1290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_81_13_1"/>
    <dbReference type="InParanoid" id="W4K5C9"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="57"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW80949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="425" mass="47920" checksum="7A4052CFF4C2A4A1" modified="2014-03-19" version="1">MSSVPRPYGRAFETVQIKDVDDGEAFDCDEEPHMLTPEQGHGYYPLTLGQQLKDGQLEIVRKLGWAGYSSVWLARTLKNSYPVQYVAVKVLTVNATAGVVRGLLGEVDALLTIKKANPHHPGYKHCMVIYDTFIAKSHHGPHICIVTDVFGPDLTYIRSFLPAQRRFFPLALTQRIIKQTLLALDYLHRECKLVHTDVKPDNVLISLKDPSEAITRLLKESPSSTYETRFEPDLSPDPIITVKSEPLGELCAEQDALRNPDICLVDYGEARSTKEQSSTQAQPDLLRAPEVLLGHAWSAPVDVWSVGCLVFEYLTGTALFQLYETDSVSFDDVYLRRIAEFIGPFPPSFLQDCSLRTRFYDEQGNLLRMDKFVPRTMEACLRNYKVLGEKDISAAAAFIRRCLTLDPRERPTALELLSDPWVKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5K0</accession>
    <name>W4K5K0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_418625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547364.1">
        <property type="nucleotide sequence ID" value="XM_009549069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5K0"/>
    <dbReference type="GeneID" id="20673492"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_418625"/>
    <dbReference type="eggNOG" id="KOG4476">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028895_2_0_1"/>
    <dbReference type="InParanoid" id="W4K5K0"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF1">
        <property type="entry name" value="CAMP INDEPENDENT REGULATORY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="413" mass="46363" checksum="CD3B80920C96D8DB" modified="2014-03-19" version="1">MQQPTLSGVHVSSVQDVQLIFYAVYLGILPMISRRLDAQERSQLRSGSCYVWAQREEAGAITGPGIERFTEGRRWSASRVRDDFLFYYEKNEPKKSSKNTNNSHRLRIRSRGWDPLIKQTCSMHFHSPLGKRKWSLTHYFSQGTCDRLIPVKDIPDLHDIGPVPPGMFTIARTPKKGRRGATAPADEARSKSSIPSGDQNPPASLSENFINLTSARMQSQFLPAPFQCTTENHFVYHYPPADETLYREDQSHSFWSATTDENMRPLSTQLTYHNYPISVDLTVERTPNVNSSWLAVHEGYVSSTAYHPIAPAPIQTTLQQSSYSVPSSPSVTDSELSYSSQGSDMSADAGNFTFVQAPAVMDANYGPIEEIEMDSDGDPIGHLAPLHALRRHHPYHRDPIDDRALQILGSRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6A8</accession>
    <name>W4K6A8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSm2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_123110</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547338.1">
        <property type="nucleotide sequence ID" value="XM_009549043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6A8"/>
    <dbReference type="FunCoup" id="W4K6A8">
        <property type="interactions" value="706"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K6A8"/>
    <dbReference type="GeneID" id="20666807"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_123110"/>
    <dbReference type="eggNOG" id="KOG3448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130474_3_0_1"/>
    <dbReference type="InParanoid" id="W4K6A8"/>
    <dbReference type="OrthoDB" id="10256176at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01725">
        <property type="entry name" value="LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000009">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016654">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829">
        <property type="entry name" value="SNRNP CORE PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829:SF2">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016394">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW80611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="97" mass="10968" checksum="786470F591A38095" modified="2014-03-19" version="1">MLIFSVFKTLTDQRVTVELKNDLSITGTLKSVDQFLNIRLDAIEVLDQGRHPHMMAVKNCFIRGSVVRYVQLPSEHVDTQLLEDATRRGAIASVISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6U3</accession>
    <name>W4K6U3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_316900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546107.1">
        <property type="nucleotide sequence ID" value="XM_009547812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6U3"/>
    <dbReference type="STRING" id="747525.W4K6U3"/>
    <dbReference type="GeneID" id="20670371"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_316900"/>
    <dbReference type="eggNOG" id="ENOG502QQMH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049058_2_1_1"/>
    <dbReference type="InParanoid" id="W4K6U3"/>
    <dbReference type="OrthoDB" id="549750at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051196">
        <property type="entry name" value="RSAD2/Viperin_antiviral"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038283">
        <property type="entry name" value="viperin_w_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21339">
        <property type="entry name" value="RADICAL S-ADENOSYL METHIONINE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21339:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT NUCLEOTIDE DEHYDRATASE RSAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01088">
        <property type="entry name" value="antiviral_proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01067">
        <property type="entry name" value="SPASM/twitch_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="8">
        <location>
            <begin position="22"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW81464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="323" mass="36607" checksum="C50C054E5CC08DC0" modified="2014-03-19" version="1">MLDSGPTVEIHPIRDIRTRDDHGQPIPVSVNHFPHRQCNYACKFCFHTALSSNKLKLEKAQGGLRLLKAAGMQRLNISGGEPFLHPEFLGKLFRYAKVELDVDTGVICNGSKVTDQWLDTYGQYPNWMGVSCDSFNEDTNELIGRRDGSKRHGEHWRRVQRIAEYCHARTPPLKFKMNTVVNRYNVEEDMNSALEVLKPQRWKVFQVLLLEGENTGPGALRNADDLVISNEEFQGFLKRHKAHNPVAEDNDAMENSYLLLDEEMRFLNCQGGKKIPGRSIFEVGVHAVLAGAGWEPETFEDRGGIYDFGGQEPPRSLPEALVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6V0</accession>
    <name>W4K6V0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA stability protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_474962</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the endosulfine family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546170.1">
        <property type="nucleotide sequence ID" value="XM_009547875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6V0"/>
    <dbReference type="FunCoup" id="W4K6V0">
        <property type="interactions" value="344"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K6V0"/>
    <dbReference type="GeneID" id="20677592"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_474962"/>
    <dbReference type="eggNOG" id="KOG4076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101493_2_1_1"/>
    <dbReference type="InParanoid" id="W4K6V0"/>
    <dbReference type="OrthoDB" id="5949865at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006760">
        <property type="entry name" value="Endosulphine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358">
        <property type="entry name" value="ENDOSULFINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358:SF6">
        <property type="entry name" value="ENDOSULFINE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04667">
        <property type="entry name" value="Endosulfine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="59"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW81533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="112" mass="12255" checksum="5DCD7354D59ABC51" modified="2014-03-19" version="1">MIPARLKKIDISKLTEEEQKLFRLYGKLPTHKNVLTKMQKDRKYFDSGDYALSKAGVAPQNAVGTTIPNPENIPHASSPPNHQGLSVSPNNNSTSPVRESALAQTEAAEAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6Y6</accession>
    <name>W4K6Y6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_426942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546205.1">
        <property type="nucleotide sequence ID" value="XM_009547910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6Y6"/>
    <dbReference type="STRING" id="747525.W4K6Y6"/>
    <dbReference type="GeneID" id="20674164"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_426942"/>
    <dbReference type="HOGENOM" id="CLU_792401_0_0_1"/>
    <dbReference type="InParanoid" id="W4K6Y6"/>
    <dbReference type="OrthoDB" id="3036049at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="38529" checksum="7D0D3481687C6DFE" modified="2014-03-19" version="1">MQGYCDLPFALDSSARVPIANRGSPWFDDGNIILFTGNIAFKVYRGLVARNSELFADLFVDIPPQRLVKTLVEECPAVRVDDSPMQLSTVLGFIHAGVAWWQPDFNNFDILGPVLHTTTQYRLTQLRDALLHPLVTRYAHRLRAYFTWDAQSAFPAPMNPVHMLNFARQAPIPTLVPVTLLELSLFVSEADLLAAREPRRRSAYAPGVLFQGDEDMCAPLRAHHRTLASGLASVLWRFVELRAPGPARHACSFGGFHAEIVAALAQGGSLAETDACFGLAMMHAIRTHAGRVAFCAECLAELDVKVMQEYQKWFLGIPPLFGLAGWQHLQAALNQLSEQRPSLTASRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7A0</accession>
    <name>W4K7A0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nickel/cobalt efflux system</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_156310</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NiCoT transporter (TC 2.A.52) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546302.1">
        <property type="nucleotide sequence ID" value="XM_009548007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7A0"/>
    <dbReference type="STRING" id="747525.W4K7A0"/>
    <dbReference type="GeneID" id="20667636"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_156310"/>
    <dbReference type="eggNOG" id="ENOG502RIYK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036094_1_0_1"/>
    <dbReference type="InParanoid" id="W4K7A0"/>
    <dbReference type="OrthoDB" id="5197598at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015099">
        <property type="term" value="F:nickel cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004688">
        <property type="entry name" value="Ni/Co_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011541">
        <property type="entry name" value="Ni/Co_transpt_high_affinity"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611">
        <property type="entry name" value="HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611:SF0">
        <property type="entry name" value="HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03824">
        <property type="entry name" value="NicO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="328"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW81678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="497" mass="53469" checksum="DB2F24817203D367" modified="2014-03-19" version="1">MLPLLPPLRLALPGSHRRLTLFGRSLLLLSAELLANAACWIVAGILFGKDPGRQPILSLSLLAWTIGLRHALDADHISAIDNATRGLISLGQLPVTCGLFFSLGHSTIVIVVNIAIAISTDVADKIGGVGDVGGIVGGRNSVSAICAAFLFIVGMANSIILYRILRKRRQNKVRRAEQLARGETPNDMDDIIEDEVNYNKTIMMKVIGPVVKFVDRPWKMYPVGVLFGFGFDTASSIALLAVSAIAKKGSDGKSIPSSEIVVLPLLFTAGMTLLDSLDSILMLYSYSGFPERSFALFEPISEVPQNATIMAQAAAADVDATAAATRPSRVGDVEQPSHPPTINEVVVDRPTESSPKSSRSQADLLIQGAGIDHTDADSNIVAVEETASREQKVKRNLMSGLSIILTFMSIMVAFSISLITIMGMIGDNCTRCQEAMNADDGGGLAGRWWRFWAAANGNSGYIGAAIVGVFLFIVGSWYGIRWAFRKLLARRQRPMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7F4</accession>
    <name>W4K7F4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_65032</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545901.1">
        <property type="nucleotide sequence ID" value="XM_009547606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7F4"/>
    <dbReference type="FunCoup" id="W4K7F4">
        <property type="interactions" value="206"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K7F4"/>
    <dbReference type="GeneID" id="20678713"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_65032"/>
    <dbReference type="eggNOG" id="KOG0858">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051898_1_2_1"/>
    <dbReference type="InParanoid" id="W4K7F4"/>
    <dbReference type="OrthoDB" id="1716531at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW81728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="209" mass="23866" checksum="1B14128D5ABFE96F" modified="2014-03-19" version="1">MPVGIEAWVNQIPPVTRAWLVLSVLTSLAVQSQLVTPLQLYFSFKASFTNMQLWRVFTNFFYFGTISLDFVFHMFFFMRYSRMLEESSFANRKADYFWLLLVSSVMLLTLSPLFNLPFLSSPLAYVPIYMWSRRHPSTPISLFGLVTITAPYLPFALVAFSWMLSGTWRAAASDLVGCAVGHVGWFVRDVWTREMIGGPTILSEAPESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7Z3</accession>
    <name>W4K7Z3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_317659</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546499.1">
        <property type="nucleotide sequence ID" value="XM_009548204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7Z3"/>
    <dbReference type="GeneID" id="20670437"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_317659"/>
    <dbReference type="eggNOG" id="KOG4569">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032957_9_1_1"/>
    <dbReference type="InParanoid" id="W4K7Z3"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF25">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845274" description="Fungal lipase-type domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="6">
        <location>
            <begin position="103"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW81908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="307" mass="32973" checksum="00D8699A7AC4B9FB" modified="2014-03-19" version="1">MAAVLFVLSVLLIKAGVSALPTPRNFRTRASPTALSPTQLSSFAPFTQFARAAYCDPSKIEGWQCGEACDALPGFEPTLTGGDANSIQFFFVGFWPDQNTVVVAHQGTDPTKMYSDLTDLNIAKRVLDPTLFPGVPDGVEVHSGFADAHEKTASQILTEVKRLMATHRTTNVTLIGHSLGGALAELDSLFMKLNLPMGTTIKGVTYGTPRVGNSKFVTLFDQQVSDFTRVNNKSDLVPIIPGRFLGFAHPHGEVHIVEPGNAVSCPGDDDAVDSQCQIKTVSNIFEGNILDHLGAYEGIFIGTPFCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8A8</accession>
    <name>W4K8A8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_16941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545765.1">
        <property type="nucleotide sequence ID" value="XM_009547470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8A8"/>
    <dbReference type="STRING" id="747525.W4K8A8"/>
    <dbReference type="GeneID" id="20668218"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_16941"/>
    <dbReference type="HOGENOM" id="CLU_2474944_0_0_1"/>
    <dbReference type="InParanoid" id="W4K8A8"/>
    <dbReference type="OrthoDB" id="3250101at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="88" mass="10577" checksum="8346FC615BD94421" modified="2014-03-19" version="1" fragment="single">LPPSQLWDHKIKLEDRIDHLLKPKLYIFSLAEQVELKKFIDKNLKKGFIQKSKSHMVLPFFFPVIDYYKLNKIVVKKKYPLPIIQELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8M8</accession>
    <name>W4K8M8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_317116</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546699.1">
        <property type="nucleotide sequence ID" value="XM_009548404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8M8"/>
    <dbReference type="FunCoup" id="W4K8M8">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="GeneID" id="20670391"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_317116"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_6_3_1"/>
    <dbReference type="InParanoid" id="W4K8M8"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF885">
        <property type="entry name" value="2OG-FE(II) OXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="194"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW82143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="339" mass="37633" checksum="E56DCB128ABED505" modified="2014-03-19" version="1">MANRPLFLANVRTDSSFDEIPVIDIQWGNKLEASVRRDIADQIRDACVNVGFFYVKNHGISEAATLGALDAAKRFFALPTDTKKKLDIHNSANYKGYTALLGENTNPDNHGDLHEGFDLGWESLPGSPDKTIERDDGAMAGSNVWPNESDIPGFREDTVKYYHTAVRLGQYLFQLFALALDLPESFFDDKTTKPAAIMRLLHYPPQAGKVEDRTIGIGAHTDYECFTILWQQPGIQALQVLNASGKWIDAAPIPGTLVVNLGDQFARWTNDVFKSTVHRAINRSGAERYSVPLFFGTDYNVPLEILPSCVSADTPAKYEVITAGEYVKSRLEATYAHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8N1</accession>
    <name>W4K8N1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_384100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546322.1">
        <property type="nucleotide sequence ID" value="XM_009548027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8N1"/>
    <dbReference type="STRING" id="747525.W4K8N1"/>
    <dbReference type="GeneID" id="20672184"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_384100"/>
    <dbReference type="eggNOG" id="KOG3417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_337083_0_0_1"/>
    <dbReference type="InParanoid" id="W4K8N1"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF99">
        <property type="entry name" value="RASGEF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="357"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="547"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="83"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="286"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW81705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="845" mass="95952" checksum="A4A71868631B8DAC" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8Q1</accession>
    <name>W4K8Q1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_317108</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546339.1">
        <property type="nucleotide sequence ID" value="XM_009548044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8Q1"/>
    <dbReference type="FunCoup" id="W4K8Q1">
        <property type="interactions" value="787"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K8Q1"/>
    <dbReference type="GeneID" id="20670389"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_317108"/>
    <dbReference type="eggNOG" id="KOG0882">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_31_0_1"/>
    <dbReference type="InParanoid" id="W4K8Q1"/>
    <dbReference type="OrthoDB" id="10264753at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01927">
        <property type="entry name" value="cyclophilin_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000003">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD repeat-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000450">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD-repeat protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="134"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="10">
        <location>
            <begin position="507"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW81725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="662" mass="73515" checksum="1FA1DEFD3BD6B50F" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4K951</accession>
    <name>W4K951_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_315539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544723.1">
        <property type="nucleotide sequence ID" value="XM_009546428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K951"/>
    <dbReference type="STRING" id="747525.W4K951"/>
    <dbReference type="GeneID" id="20670233"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_315539"/>
    <dbReference type="HOGENOM" id="CLU_128854_0_0_1"/>
    <dbReference type="InParanoid" id="W4K951"/>
    <dbReference type="OrthoDB" id="2186602at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="165" mass="17900" checksum="2AC004FB952DB7DF" modified="2014-03-19" version="1">MRRGGAKRNAIKKVLLPLPARPCLSCAPAHTRKRLLTPHLFPCSLLGGEGTTTLPGTLPPDAFFSKHAHSTLRTAAHASHERTLSSASGYAHHHVAGAARSTTSPAKQRYVTDAHGLEIVKKIRQGEVELRDRTIVLCGIKANVRPARFALHVLCCHIRDRSVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9T5</accession>
    <name>W4K9T5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_57843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544680.1">
        <property type="nucleotide sequence ID" value="XM_009546385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9T5"/>
    <dbReference type="GeneID" id="20678409"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_57843"/>
    <dbReference type="eggNOG" id="ENOG502S3G3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_32_0_1"/>
    <dbReference type="InParanoid" id="W4K9T5"/>
    <dbReference type="OrthoDB" id="128646at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="122" mass="14047" checksum="C203D25C7E4B6C1B" modified="2014-03-19" version="1">MNDRIITPIRLSVKVSNRSQYAGAKATIDSACEGVIANETWVRRHRFPTYTLNNPIRVRNVDDTINKAGLIRSALDVNLTIRDIRGRTHTERVQMFISNLGKDDLILGTDWLKYHDPSIEWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9U9</accession>
    <name>W4K9U9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_473768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544969.1">
        <property type="nucleotide sequence ID" value="XM_009546674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9U9"/>
    <dbReference type="GeneID" id="20677539"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_473768"/>
    <dbReference type="eggNOG" id="ENOG502SP7E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044614_9_2_1"/>
    <dbReference type="InParanoid" id="W4K9U9"/>
    <dbReference type="OrthoDB" id="3174319at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW82622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="323" mass="36480" checksum="8D88BFD44D75CF6A" modified="2014-03-19" version="1">MSSDDAQYTYATLKPLIIALACETGFYVLSILSFAVSTYILVRKGLKTRAILIMWITTFIMFAVSTCHFLLQWVGGMDKIRTGLASSFLEDYYGEQLLSIADIYLPIVNYSLSDGIVLWRVWVMWERSVKVLIFPVLFYCTLAAGLYMSFSRLGIGLIYASTLTTNIIATTLMAVKAWQHRRLLKSHLNNTEYRSWALSVLVLLVESGTLYCVIWTIFFLTWCFVSSNFNVTSASVMEILPGITVQVSGIYPTAVIALAALQRTTWDMSVGRDMFHNAPHVEMRFATRDTRSVSSTIQSDHRPTPSDDEELHASEMRAMNEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KA57</accession>
    <name>W4KA57_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_316845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545003.1">
        <property type="nucleotide sequence ID" value="XM_009546708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KA57"/>
    <dbReference type="GeneID" id="20670364"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_316845"/>
    <dbReference type="HOGENOM" id="CLU_121527_0_0_1"/>
    <dbReference type="InParanoid" id="W4KA57"/>
    <dbReference type="OrthoDB" id="2722301at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="151" mass="17307" checksum="6B230642A3AB421A" modified="2014-03-19" version="1" fragment="single">VDVMSMLRELSKPLWEIDFPSLPNVWGISAPWLLSHGYRLYPTWPEGRYDSTICNPDRPAPRDLPHPYAYSAYFPGPCNDVSMSQNVIGAQDEQWRDVVIKVVAKGSQELTIFKILAETPELFDSRTFPCVIPVLEILDTSYDYKFVVLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAC6</accession>
    <name>W4KAC6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_315737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009546740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAC6"/>
    <dbReference type="GeneID" id="20670255"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_315737"/>
    <dbReference type="HOGENOM" id="CLU_1943117_0_0_1"/>
    <dbReference type="InParanoid" id="W4KAC6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="130" mass="14577" checksum="037895FED273D019" modified="2014-03-19" version="1" fragment="single">LGAHSTSTLISGSIFYLGALFTIKTYIQLWNKPAFAPHSSELIRTRLNHRNRLHRLPKTCHPRRSASFAFVLVSSLVPPSSLVYCQSPVWLLKHVVVGRDTTFSLPTESPTRPTERSVGVRRSPETVRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAC8</accession>
    <name>W4KAC8_HETIT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_163173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545075.1">
        <property type="nucleotide sequence ID" value="XM_009546780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAC8"/>
    <dbReference type="GeneID" id="20667826"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_163173"/>
    <dbReference type="HOGENOM" id="CLU_3106633_0_0_1"/>
    <dbReference type="InParanoid" id="W4KAC8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="51" mass="6155" checksum="118C8676910D5DDC" modified="2014-03-19" version="1">MPDALKHCQFTDFFSSSSPHLLRSLIRLYTDNHTQSVFMNYRYQLPSQYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBN9</accession>
    <name>W4KBN9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_163562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545431.1">
        <property type="nucleotide sequence ID" value="XM_009547136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBN9"/>
    <dbReference type="GeneID" id="20667854"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_163562"/>
    <dbReference type="HOGENOM" id="CLU_2512903_0_0_1"/>
    <dbReference type="InParanoid" id="W4KBN9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW83149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="85" mass="9698" checksum="5C445650C226B925" modified="2014-03-19" version="1">MEKDEVWHLQTVSHTWKCDPILKIVTTVNCERALSLSLNFTGPIVCTPCMQIDFKNALCCKVPLPKNAKYLNTCYRDESTIMAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBT2</accession>
    <name>W4KBT2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitochondrial import inner membrane translocase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_28638</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544617.1">
        <property type="nucleotide sequence ID" value="XM_009546322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBT2"/>
    <dbReference type="STRING" id="747525.W4KBT2"/>
    <dbReference type="GeneID" id="20669292"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_28638"/>
    <dbReference type="eggNOG" id="KOG0723">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_13_5_1"/>
    <dbReference type="InParanoid" id="W4KBT2"/>
    <dbReference type="OrthoDB" id="240298at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000001">
        <property type="entry name" value="Import inner membrane translocase subunit tim14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763:SF28">
        <property type="entry name" value="GEO10507P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW83204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="79" mass="8654" checksum="D958CCAAA357D4F0" modified="2014-03-19" version="1" fragment="single">LRRGIIGGKGAAEQWVKGGFKAKMDRKEAIAILGLKDGPLLKTKLKDAHRHIMLANHPDRGGAPYLASKINEAKDLLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBU1</accession>
    <name>W4KBU1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_106871</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545589.1">
        <property type="nucleotide sequence ID" value="XM_009547294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBU1"/>
    <dbReference type="GeneID" id="20666197"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_106871"/>
    <dbReference type="eggNOG" id="KOG4580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079971_1_1_1"/>
    <dbReference type="InParanoid" id="W4KBU1"/>
    <dbReference type="OrthoDB" id="2243669at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF2">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 3 COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="100"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW83322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="215" mass="24330" checksum="70FBFCB1B0239645" modified="2014-03-19" version="1">MSNTLRPSTSTSGSEDPSLIRRSWHAMSDLLFPFSPSALAQLPKNLPRPIRYTRADAIPDAERDEDGQMPTVRDYHSINSVPPQVRIPKKIPTPVRVEGKVWFANERTWISYLNMSMLIGALAVALFNASKDDVARNFAYTYAAISIGIMVYGYAVYQHRITMIRRRDPGHFDQILGPIIISAFLFFAVLANFVIRVRELQRKNISIPGLSFFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4KC22</accession>
    <name>W4KC22_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aminodeoxychorismate synthase</fullName>
            <ecNumber evidence="4">2.6.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Para-aminobenzoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">p-aminobenzoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_157133</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11672"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58406"/>
            <dbReference type="EC" id="2.6.1.85"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4-aminobenzoate from chorismate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.85" evidence="4"/>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545199.1">
        <property type="nucleotide sequence ID" value="XM_009546904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KC22"/>
    <dbReference type="FunCoup" id="W4KC22">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KC22"/>
    <dbReference type="GeneID" id="20667700"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_157133"/>
    <dbReference type="eggNOG" id="KOG1224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006493_0_0_1"/>
    <dbReference type="InParanoid" id="W4KC22"/>
    <dbReference type="OrthoDB" id="64220at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046820">
        <property type="term" value="F:4-amino-4-deoxychorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008153">
        <property type="term" value="P:4-aminobenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010117">
        <property type="entry name" value="PabB_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01823">
        <property type="entry name" value="PabB-fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF18">
        <property type="entry name" value="AMINODEOXYCHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="10">
        <location>
            <begin position="15"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="12">
        <location>
            <begin position="283"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="11">
        <location>
            <begin position="466"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW82890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="779" mass="85399" checksum="95F9E09E6C104CAC" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4KC39</accession>
    <name>W4KC39_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_450446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544988.1">
        <property type="nucleotide sequence ID" value="XM_009546693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KC39"/>
    <dbReference type="GeneID" id="20676048"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_450446"/>
    <dbReference type="HOGENOM" id="CLU_741980_0_0_1"/>
    <dbReference type="InParanoid" id="W4KC39"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW82646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="373" mass="42109" checksum="3E166242050ABBAA" modified="2014-03-19" version="1">MAEISGPPFHRLVDSYNSTPVPNNSREASVLLLECTPASMQREPVATREGFLENRSVGQREEEGTHSSDDRQAAAFVMTHGEYASVDLRDQYGRQAAFIPLSAAPEVLSAGDDQPQFVRRGSFVEVASTGEVVARLDEAPSSFPDAGYLSDIAHTHPVTFFELMDQTVVGYSPNMVPNIPIFPFIPGASYLPALAHATIAVVVFWRRRIQRLVLRVKKNFEEREEEASEEEIIEKDSEVQRELKHPCVIHLLDTPGSHSDFASLLVHLRDWSPLFTVEEGAFFRTTIDYFRLVGRWDFAEALHTLLGLHFADDDIIRWLVNSNLADPQRSTHQDLYDNSFRRAEAKVHALILCEDPCLMIKEEEDPLGTDRYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCI6</accession>
    <name>W4KCI6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_458781</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545734.1">
        <property type="nucleotide sequence ID" value="XM_009547439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCI6"/>
    <dbReference type="STRING" id="747525.W4KCI6"/>
    <dbReference type="GeneID" id="20676947"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_458781"/>
    <dbReference type="eggNOG" id="KOG0634">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_6_1"/>
    <dbReference type="InParanoid" id="W4KCI6"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF19">
        <property type="entry name" value="KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="105"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW83488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="458" mass="49801" checksum="CC86720D7A6CFF61" modified="2014-03-19" version="1">MTSQTAASTDRLNGLNGTQIKECSILPAEYYASFISTAAKDRKPSPIRGLFPLEQRPGVISLLAGKPNGATFPLTSLSFTARSPTEPGKESTLTVDGAALVEGLQYSATSGIPSLVKWLTDLQEREHHRSTDQGWRISVTSGSQDAIYKAAGVLLNPGDSILVEMPVYAGVIPIFKSLGSEMIEVETDAEGIVSSSLRSILESWPASKSKPKALYTVPYGCNPTGMTATLERRLETLTLAREHKFIILEDDPYYYLYFGFAPRIPSYFALEAQTGSAGHVLRFDSFSKILSAGIRIGFATGPQPLLDAMDLHTSSANLQPASLTQSITFALLDSWGPLGFQAHTQSVSNFYKQKRDVFEAAMRQQLEGLAEWTTPEAGMFFWFKLLLSDDPNVEADTSDLIATKALEGGVLALPGTVFIPNGAKTAHVRAAFSLLEEPEVNEALRRLRLVILEERGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDD5</accession>
    <name>W4KDD5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_119456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545587.1">
        <property type="nucleotide sequence ID" value="XM_009547292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDD5"/>
    <dbReference type="GeneID" id="20666648"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_119456"/>
    <dbReference type="HOGENOM" id="CLU_2133821_0_0_1"/>
    <dbReference type="InParanoid" id="W4KDD5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW83320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="113" mass="12559" checksum="0C12D466E4016178" modified="2014-03-19" version="1">MSTGSTTTESIDVDSSNVRMWFLEEPADGYQYQNDIYTPDDINGIDTDVANTSESPGIELELKFETGIVDLVSSDITAGRINVPIEEPLGDDFSNFFQNLPSWGICWNKQSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDE7</accession>
    <name>W4KDE7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GMC oxidoreductase 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gor9</name>
        <name evidence="8" type="ORF">HETIRDRAFT_54732</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544655.1">
        <property type="nucleotide sequence ID" value="XM_009546360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDE7"/>
    <dbReference type="STRING" id="747525.W4KDE7"/>
    <dbReference type="GeneID" id="20678317"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_54732"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_7_2_1"/>
    <dbReference type="InParanoid" id="W4KDE7"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="595"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="638"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW83335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="665" mass="72131" checksum="543EA9A841BAE237" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4KE23</accession>
    <name>W4KE23_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_123705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543725.1">
        <property type="nucleotide sequence ID" value="XM_009545430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KE23"/>
    <dbReference type="STRING" id="747525.W4KE23"/>
    <dbReference type="GeneID" id="20666836"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_123705"/>
    <dbReference type="eggNOG" id="KOG4245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039329_2_1_1"/>
    <dbReference type="InParanoid" id="W4KE23"/>
    <dbReference type="OrthoDB" id="2832284at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01292">
        <property type="entry name" value="metallo-dependent_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF28">
        <property type="entry name" value="ISO-OROTATE DECARBOXYLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="4"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW84004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="327" mass="35041" checksum="ADF651B103BCAC08" modified="2014-03-19" version="1">MSAIDVHHHIFPAALPKAALSRAVGFRTPPAHLPWSPALSLRAMDALGVELAVLSVPTGHFPDDVRALNDQMRAACVQHPGRFAFWGCAGDLRDTKGALDLIAYALDDLGAVGIAVSSVYGEANDAKYLGDDVFDPIWEELDRRDAVVFLHGAQTPSSTPFPSDLLGIPITEVPNETFKAIAHLVVAGKTTRFPRLAFVLAHMGGTALALAPRLAGLARYMGAALDETHILRELRRACWWDTALSAGPGPLAAAEAWGVGARVVWGSDFPAVPLETIQWFEAGLRAFYAPKDGAGDDARLRGIYREHVLELFASRGIDLFALAPAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KER2</accession>
    <name>W4KER2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_313161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544006.1">
        <property type="nucleotide sequence ID" value="XM_009545711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KER2"/>
    <dbReference type="GeneID" id="20670008"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_313161"/>
    <dbReference type="HOGENOM" id="CLU_880169_0_0_1"/>
    <dbReference type="InParanoid" id="W4KER2"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="316" mass="34853" checksum="E28CC88E44A81FE7" modified="2014-03-19" version="1">MISIEAPDLCAGEGGERHNSPPSVFQGIDYLFTISVSAPRNVTIADKSKHAKLTASRPQSIQKLLVSEGGAPQPGPRAISDLLPSWSSGGRPPRPRRLIRNCLRQGTTQATRQPDSQPVPSKHGPQLPRTVAAPRRTRPFPCSVDDHLLTRERHAPPLAMTISIVICARHDTICGSARSTPGQRDETKDNASDEINRYVTRGSTTRSGIATQHGISKCMWRGTAGNREDCEGKKEDSTTIARHGGNDQKKQRQTKQSKIVIEKKKKKGTHKWEGEKEKRDSAGTEETQRGTLARCRGTRATAQPRTEERYVHVNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEX5</accession>
    <name>W4KEX5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic peptide chain release factor GTP-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ERF-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">ERF2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Polypeptide release factor 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Translation release factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HETIRDRAFT_34038</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543159.1">
        <property type="nucleotide sequence ID" value="XM_009544864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEX5"/>
    <dbReference type="FunCoup" id="W4KEX5">
        <property type="interactions" value="437"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KEX5"/>
    <dbReference type="GeneID" id="20671767"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_34038"/>
    <dbReference type="eggNOG" id="KOG0459">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_3_5_1"/>
    <dbReference type="InParanoid" id="W4KEX5"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03704">
        <property type="entry name" value="eRF3_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04089">
        <property type="entry name" value="eRF3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000017">
        <property type="entry name" value="Eukaryotic peptide chain release factor GTP-binding subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000061">
        <property type="entry name" value="Translation release factor eRF3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003285">
        <property type="entry name" value="Sup35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01343">
        <property type="entry name" value="YEASTERF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tr-type G" evidence="14">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETW83621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="435" mass="47866" checksum="689B444BD3692196" modified="2014-03-19" version="1">MGGNILYLSGTVDKRTMEKYEKEAKDAGRETWYLSWALDSTPQERLKGKTVEVGRAYFETDTRRYTILDAPGHKTYVPSMITGAAQADVAILVISARKGEFETGFERGGQTREHIMLVKTAGVGKIIVVINKMDDPTVGWEKSRFDEIKDKLTPFVRGAGYNPKTDVTWMPVSAYTGANLKDRVASSVCAWWDGPSLLEHLDKMPMVDRHLHAPLMMPISEKYKDLGTIVVGKIESGHIRKGDTLLLMPNRDTVEVATLYNELEEEVPAAASGDNVRLRLRGVEDEDISPGFVLTSPAKPVRAVRQFEAQLAILEHKNIICAGYTAVMHVHTLAEEVALAGLLHYFDKATGRKSKKPPQFAKRGQRIVALIETAAPVCIERFADYPQLGRFTLRDEGRTIAIGKVTKLIESGVDTDEVVGGVANLSVASSAAPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KF71</accession>
    <name>W4KF71_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_170983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544153.1">
        <property type="nucleotide sequence ID" value="XM_009545858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KF71"/>
    <dbReference type="GeneID" id="20668314"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_170983"/>
    <dbReference type="HOGENOM" id="CLU_2015561_0_0_1"/>
    <dbReference type="InParanoid" id="W4KF71"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="123" mass="13744" checksum="5E3C89B66AA8C0CE" modified="2014-03-19" version="1">MAHVPPRSQNLACSAASSFWLSYSLAGSSILLITSVRIGPRCPASSLCFNVGSLRHRRRALRGSFRVHTTVSIQTVFFPLSIYTWVWVRISSNLHLPHASALVCLFLRHTTCTFMILYMSSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGA0</accession>
    <name>W4KGA0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_473485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
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                <person name="Kues U."/>
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                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
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                <person name="Yakovlev I."/>
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        </source>
    </evidence>
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                <person name="Broberg A."/>
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                <person name="Cullen D."/>
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                <person name="Lee Y.H."/>
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                <person name="Lind M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="InParanoid" id="W4KH64"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW85198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="288" mass="31162" checksum="E644C4F8BC87079F" modified="2014-03-19" version="1">MARDIVEAPRDTVLRVLAEVPPQVLVEEAPELVPELPPSPETASEPVLLEHHVHVEEEPRQKKAKNGEGRDGREEGASQGASGATAGRRIVKRPRMPPIAGYGRFSVKLPSDYAERERETVGERGQMLVVHPQAHGSAPQQTTLKSTTSTHRVENPTGDPVPEAITQSIGGPWTSTHGEEQRGARKRKRADPHVCDGTDGCSKRLSCPYDMPRHKATLRHGGQREFACGDCPALFVRKDEVHRHKREHCPNRGRKHSGEDGPSQGPRHDGPEGGGGGMGGIGDGLLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHC6</accession>
    <name>W4KHC6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_168609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542004.1">
        <property type="nucleotide sequence ID" value="XM_009543709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHC6"/>
    <dbReference type="GeneID" id="20668171"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_168609"/>
    <dbReference type="HOGENOM" id="CLU_1378281_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHC6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW85119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="198" mass="21632" checksum="929868ADDFC53A40" modified="2014-03-19" version="1">MFGIVALLALVPTVLIFRLTCLVLTVSDVSDCASSSFITTMIAVIFSGSITLLSLVGVILVHLKQRRARLSKPPRHLPNRREAEPMRERGNNAQGMAPSRERGNNAQGMAPSRERGNNAQGMARSRERGNNAQGMAPSRERGNNAQGMAPSRERGNNAQGMARSRDVGRQSRKQNYTNNDWGCETCSECDPCLPFAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHK6</accession>
    <name>W4KHK6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_424645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542178.1">
        <property type="nucleotide sequence ID" value="XM_009543883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHK6"/>
    <dbReference type="GeneID" id="20673994"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_424645"/>
    <dbReference type="eggNOG" id="ENOG502STHT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_706071_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHK6"/>
    <dbReference type="OrthoDB" id="4951847at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="391" mass="44741" checksum="41EF687B7ACE36F0" modified="2014-03-19" version="1">MSTKSNDVSFETVLTELHYLLLGIPPEPNLPFMENSQDSHYACFLNFSLDSDLMQKIKDGVEVFSEQFKSVFGWQTWSTGDGIIPIVEHGPAICAVVDVLQKYHDQYPSNEVIMKWGRDVLRGVRQIYTKKGLDYPLVRDQLPRQIPLQLIDSTGVNGSQAKHFEAQENTRPSKNRCPLRLTPDELMSKLAVIGCRWTKRGNRVEARVYSHATSCEHLQHSKSIEHRTLWEWACLAQKRSSLGAKITKHNDTASESGRGLLSQELPISRITPNLKQPSVIHATRDARRKILTRKQLEMKADLQCRIDHCIMRLICMCSLVPNAIDSSEWKELLTTLNPDIHPIMIMFYRALMAAEVYIKWASFPTLQTTHTQGMELLVFPGWKETIREAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHZ3</accession>
    <name>W4KHZ3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_230253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542166.1">
        <property type="nucleotide sequence ID" value="XM_009543871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHZ3"/>
    <dbReference type="GeneID" id="20668708"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_230253"/>
    <dbReference type="eggNOG" id="ENOG502S3G3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068189_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHZ3"/>
    <dbReference type="OrthoDB" id="128646at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="350" mass="40877" checksum="3776EA3ED27DF714" modified="2014-03-19" version="1" fragment="single">MNDRIITPIRLNVKVSNRSQNAGAKATIDSACEGVIVNETWVKRHRFPTYTLNNPIRVRNVDDTINKAGLIRSALDVNLTIRDISGRTHTERVQMFISNLGKDDLILGTDWLKYHDPSIEWRRREVHFDRCPQKCQQPYGFTRAREEPPYSRRLSNVEPRHKPRINEREKQRLEHLRRLSEDVGLRNHSGTFGVRLRAYLKRKWLLKDIRKYAEEKRKAQDKPSLSPNVGEPDLPDKPSGKQAIEEPVIRKLAPEPSGFASFDQDLEDEIVVTNLKERVPKAHHEYLDIFSERKSQRLPEHTYWDHAIDLKPTFKPQVPKIYALSPEKHDELGKFIKEHLTRGTIRRSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIB7</accession>
    <name>W4KIB7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Checkpoint protein RAD24-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_308672</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542446.1">
        <property type="nucleotide sequence ID" value="XM_009544151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIB7"/>
    <dbReference type="FunCoup" id="W4KIB7">
        <property type="interactions" value="501"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KIB7"/>
    <dbReference type="GeneID" id="20669606"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_308672"/>
    <dbReference type="eggNOG" id="KOG1970">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018598_1_0_1"/>
    <dbReference type="InParanoid" id="W4KIB7"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057927">
        <property type="entry name" value="RAD24-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03215">
        <property type="entry name" value="Rad17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25812">
        <property type="entry name" value="RAD24_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Checkpoint protein RAD24-like helical bundle" evidence="8">
        <location>
            <begin position="309"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW85602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="595" mass="66291" checksum="DEE72BD384B8216F" modified="2014-03-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KII2</accession>
    <name>W4KII2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_168115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542503.1">
        <property type="nucleotide sequence ID" value="XM_009544208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KII2"/>
    <dbReference type="GeneID" id="20668147"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_168115"/>
    <dbReference type="HOGENOM" id="CLU_804244_0_0_1"/>
    <dbReference type="InParanoid" id="W4KII2"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="345" mass="38482" checksum="9079DEF4645E4D19" modified="2014-03-19" version="1">MQELSHDVTRKYAPLVLPDSIHCQHNALLESSSTLYWDPPSHVQMTYDVGHGRSPDYGTQSIVSAVYSGSRYRLVGLSQHLTQGLAHHVNFHNDAMLHQDYHLISPVESAVHRDGDMDHQYMYYRSSYSSSVRFHQDAADASLSGYIPHQPAQSGISGDVEMTGTQGLHVPMNELMAHTEKQVAPSYFEDNSQSGTYLEETFGKESVKSLLFQDPSDPVIKSAPYNSNPPVHIVKQKLFIPYDRTKRTLQERSKNPLPSPTFFNCDDGAIGVSLGRARQGHGLAMNSNHSSPLGDRQTLQLKIWVHCLLPACLLKGAQSISIANRFTTPQSLTWTSNLQQNAQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIJ8</accession>
    <name>W4KIJ8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phytase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_154432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542518.1">
        <property type="nucleotide sequence ID" value="XM_009544223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIJ8"/>
    <dbReference type="FunCoup" id="W4KIJ8">
        <property type="interactions" value="203"/>
    </dbReference>
    <dbReference type="GeneID" id="20667493"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_154432"/>
    <dbReference type="eggNOG" id="KOG1382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020880_2_2_1"/>
    <dbReference type="InParanoid" id="W4KIJ8"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF42">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="649" mass="71137" checksum="ADA4FFFC570FA7D0" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIU3</accession>
    <name>W4KIU3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_168518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542113.1">
        <property type="nucleotide sequence ID" value="XM_009543818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIU3"/>
    <dbReference type="GeneID" id="20668161"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_168518"/>
    <dbReference type="HOGENOM" id="CLU_068710_0_0_1"/>
    <dbReference type="InParanoid" id="W4KIU3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844310" evidence="2">
        <location>
            <begin position="27"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW85240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="347" mass="37958" checksum="9BE6CFD38D615EB0" modified="2014-03-19" version="1">MGEVAGQRSVAFVMLWRIAVAAKAHALTDGWCQRDIGDPQLYKASPFSPLSFHHALFLPTTPTPLILSHALHYLLSSLRPPSSVQVIRHDRLKHDVKLIGTIAFKHDSKFTGRVVSSGDTALGSVALVCGIGLYRSLEVASMFGCWCVSSTCLGSVLPVLLILLLFLPLVVLVSYHYLLRFDVLGCGLLALCCVVCSLWVPVSLCSLFDLACLLCLACSFSSSPCLLSWPSLFLLIAVACFLCFTWSSLSPFLAVALILVSDVSCQSLLVSVFVLAYLNLIFLLVYLVLAVIHSRWPWSISATLSISLASLRFLSLSFGSSWRPSQPILVPHRQTRLFQSARDRVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIU9</accession>
    <name>W4KIU9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_309762</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542595.1">
        <property type="nucleotide sequence ID" value="XM_009544300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIU9"/>
    <dbReference type="FunCoup" id="W4KIU9">
        <property type="interactions" value="711"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KIU9"/>
    <dbReference type="GeneID" id="20669710"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_309762"/>
    <dbReference type="eggNOG" id="KOG1461">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012507_0_0_1"/>
    <dbReference type="InParanoid" id="W4KIU9"/>
    <dbReference type="OrthoDB" id="424572at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04197">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11558">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000066">
        <property type="entry name" value="Translation initiation factor eIF-2B subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035543">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044123">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="10">
        <location>
            <begin position="517"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="431"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="681"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="442"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="700"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="718"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW85768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="743" mass="80839" checksum="1BB6A991173EAC33" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJ68</accession>
    <name>W4KJ68_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_379854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542582.1">
        <property type="nucleotide sequence ID" value="XM_009544287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJ68"/>
    <dbReference type="STRING" id="747525.W4KJ68"/>
    <dbReference type="GeneID" id="20671993"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_379854"/>
    <dbReference type="eggNOG" id="ENOG502SRMA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051224_1_0_1"/>
    <dbReference type="InParanoid" id="W4KJ68"/>
    <dbReference type="OrthoDB" id="3188789at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="42220" checksum="ABAFB19763ABD1D6" modified="2014-03-19" version="1">MSSPFIIIRIVFLSLLVYLNSLVLVFAAWNIGATNSVGILVHGAAIFLIFNACAIFLFVIVALAPLVVPKASTAFVGFECGWTGVLSVLQLGASISATISGPPALCIPRAPFSVCASATILVPISWLAAILMFGYFVMIFGAAIAHLSLHPFIWTRSFYSIPWFVGPEVTRSSAPQLPPLLLHDPIRHSIIQGTYTSQGLPPWDIEKNLQPPPLLKVRSLASIVGANSPLTSIFHRTRPTASNLSLSPVITQSTGEGEKVPAWYARQKPFRPGRDLPFTIDTVSPSAYLPEASTSVSKGKKRDPMEGSGFVKMTKEEKPFQGSSIYPEKETRLLYPYPRPVPAPSDPDKPIDMGRMTQWMEADAARGITLSDMPRPQSWERELYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJF6</accession>
    <name>W4KJF6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_424731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542312.1">
        <property type="nucleotide sequence ID" value="XM_009544017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJF6"/>
    <dbReference type="GeneID" id="20674003"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_424731"/>
    <dbReference type="HOGENOM" id="CLU_1796718_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJF6"/>
    <dbReference type="OrthoDB" id="2322999at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="144" mass="15915" checksum="D7F98D9B55B177F1" modified="2014-03-19" version="1">MRSGRMEALLKSHYGDPSRVEAQNTPSWGESLSLRHRRHEVGNFAGPDGVEPELTGEIELQWGQDILFTVVVRTSILKQGVESLILTSWHVPATGVPDGKPLAGEHWNKVITPKETHKVHYDGAKPLIPDTLAKVLVEQGIIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJL9</accession>
    <name>W4KJL9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_407831</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542835.1">
        <property type="nucleotide sequence ID" value="XM_009544540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJL9"/>
    <dbReference type="FunCoup" id="W4KJL9">
        <property type="interactions" value="933"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KJL9"/>
    <dbReference type="GeneID" id="20672632"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_407831"/>
    <dbReference type="eggNOG" id="KOG0096">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_13_0_1"/>
    <dbReference type="InParanoid" id="W4KJL9"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000131">
        <property type="entry name" value="GTP-binding nuclear protein Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW86053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="212" mass="23986" checksum="4D82680024181101" modified="2014-03-19" version="1">MTEIPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYIATLGVEVHPLSFSTNYGTICFNVWDTAGQEKFGGLRDGYYIQGQCGIIMFDVTSRITYKNVPNWHRDLERVCENIPIVLCGNKVDVKERKVKTAQVTFHRKKSIQYFEISAKSNYNFEKPFLWLGRKLVGNPTLDFVAAPALAPAEVEVDPALMEQYRQEMAQAEAVPLPEEDDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJZ4</accession>
    <name>W4KJZ4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome biogenesis protein NSA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_167763</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NSA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542810.1">
        <property type="nucleotide sequence ID" value="XM_009544515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJZ4"/>
    <dbReference type="STRING" id="747525.W4KJZ4"/>
    <dbReference type="GeneID" id="20668132"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_167763"/>
    <dbReference type="eggNOG" id="KOG3881">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033769_1_0_1"/>
    <dbReference type="InParanoid" id="W4KJZ4"/>
    <dbReference type="OrthoDB" id="18388at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22857">
        <property type="entry name" value="WDR74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037379">
        <property type="entry name" value="WDR74/Nsa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038">
        <property type="entry name" value="NOP SEVEN ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038:SF4">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="362"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW86024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="415" mass="45300" checksum="64F8E5C52E2176EF" modified="2014-03-19" version="1">MARFLTGDELGNIKSLTYTSVDGHKTDVQTLYDGSGSGKNKSIQALAVASSVSERGRVVAAAHADGSATVFNLKDSSIELLHEWKETRLRAGQNYVGLDIFQQGIYSCTSNGALRRTVNIEDESLTSQTAVLPMRLSDWRLSSDGSTFAYVGDEVELSVCDVEQIFASKTPPGATASVNGQKRKRRDGLLPGEIWRARNVANDSLSLRQPVHNNCLTYIMPSLSASQHHLLVGTQFGNVRRYDTRSSRRPVADWQKVAKTGGIKAVEKGFHEHEALVTDQGSSVFSLDLRNGRVAYGYKGLSGTATSLAPSPTVLASVALDRYARIHSTFPPAEPGQQQEHKGGVLDTVFMKSTPTVVVWDRDSSNMETNTLDESGGDGEAEDDVWDDMESVQDEGSDVEVDRSKRRELKKARSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KK17</accession>
    <name>W4KK17_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit TIM54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_60095</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM54 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541826.1">
        <property type="nucleotide sequence ID" value="XM_009543531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KK17"/>
    <dbReference type="FunCoup" id="W4KK17">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KK17"/>
    <dbReference type="GeneID" id="20678495"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_60095"/>
    <dbReference type="eggNOG" id="ENOG502QPMQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033744_0_0_1"/>
    <dbReference type="InParanoid" id="W4KK17"/>
    <dbReference type="OrthoDB" id="5598305at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021056">
        <property type="entry name" value="Mt_import_IM_translocase_Tim54"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11711">
        <property type="entry name" value="Tim54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="217"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="352"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW86192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="489" mass="55051" checksum="C65C85A74385D876" modified="2014-03-19" version="1">MSLPEGTPPSTVLPPQKSGARAALEYTGIPPSWFEKRPRLPSRNWLIFIGVTSTVIGFYVHDRRECKRIREEYASRVRHLADEPLHSLEFARKVTVYGAKWPGDDDWDRSTRYFRKYVKPIFVAAAVDFEIIAGKRHGDLATRIAEDIKQQRRISLGLESPNVPGVPLPTQQTPEEKQRRLFAGGTVLVGRPAFKEYMAGLRRGWTEGLQKVDREESLAQELESDGRFDEPEETQNHIHSEDVDNEPLPTPSRLPPSRPGVFSPLSMRAPPPRSPIPEKTQSTGADVPPPARIPPQPPLLLVPFVNHIGLSQIPYMIIDFFNERAQVKAGAEAAYRLVMNETRPFIGPPSEPSQAESSSVSASPSMTNTDLAFDTKAELFYKSSTSKLPSETQKVRDDYYKSLPAKLDTARQLARREREPTSDEVAAPPPTEVELRAERLNKELRWRGDEKGWDIIRPDAPVDWDSRMEGALSVFVDPQDGHSNEVLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKB5</accession>
    <name>W4KKB5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_311491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543029.1">
        <property type="nucleotide sequence ID" value="XM_009544734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKB5"/>
    <dbReference type="STRING" id="747525.W4KKB5"/>
    <dbReference type="GeneID" id="20669876"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_311491"/>
    <dbReference type="eggNOG" id="ENOG502T7R5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1245520_0_0_1"/>
    <dbReference type="InParanoid" id="W4KKB5"/>
    <dbReference type="OrthoDB" id="3182995at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="25149" checksum="F9820422AA232306" modified="2014-03-19" version="1">MDGRKYCLTQISTEPINAIANISGCLQGSCLTARSLLELPERIDQRRSRIYSAKLTFDGPEYDFPEQCCIKIAYGDQEYRDLDREYDYYSLELQSLGGIAVPRCYGFFGAEIEGVLVGCLVMDLCIGTDVILPDYAEFKRRIMMAICKLHSVGIEHGNLFADYRHYVMNSWSVLIVDFSAARRHNCPGLQSVGGCDELIQAERLFGDNKFGVLSTFPRTWYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLV0</accession>
    <name>W4KLV0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Voltage-gated potassium channel beta 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bKv2</name>
        <name evidence="5" type="ORF">HETIRDRAFT_145167</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540767.1">
        <property type="nucleotide sequence ID" value="XM_009542472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLV0"/>
    <dbReference type="FunCoup" id="W4KLV0">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="GeneID" id="20667067"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_145167"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_1"/>
    <dbReference type="InParanoid" id="W4KLV0"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF2">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="32"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW86782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="359" mass="39938" checksum="4ED139C80B51AB42" modified="2014-03-19" version="1">MSGSEVKLEYQQKNMPFRRLGSSGLRVPVFSLGGWLTFGGTVVGDPVKDIVKTAFENGINMFDEAEAYAKGQSEVELGRVLKELGLRRTDIIVTTKLYWGAERKGPNDQGLSRKHIVEGTKESLQRLQLDYVDVIFAHRPDHTVPMEEVVRAFHWVIEQGLAFYWGTSEWSAREIEEAHHVADKYGLHAPVAEQCQHNLVHRERPEGEYGPLYQKYNMGTTVWSALAGGILTGKYNNGVPDGSRLDTNKEFLAHRLKFLESEEGKKQIEIVKQLTAVAETELGCKVSHLALAWVAKNTNTSTVILGATSPEQIVDNLKALDVIPKLTPEILAKIEAIVNNKPAPPPDFGRPGLDPHGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KM58</accession>
    <name>W4KM58_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_244237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540485.1">
        <property type="nucleotide sequence ID" value="XM_009542190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KM58"/>
    <dbReference type="STRING" id="747525.W4KM58"/>
    <dbReference type="GeneID" id="20669032"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_244237"/>
    <dbReference type="eggNOG" id="KOG1164">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3001997_0_0_1"/>
    <dbReference type="InParanoid" id="W4KM58"/>
    <dbReference type="OrthoDB" id="3203292at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="57" mass="6443" checksum="0E80F051802F78F2" modified="2014-03-19" version="1" fragment="single">KTLTGSVGVPFICWFDMECNYNAMAINLLGPLLKDLFNFCNQKFSLEMVLLLANQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KM78</accession>
    <name>W4KM78_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_121207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540503.1">
        <property type="nucleotide sequence ID" value="XM_009542208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KM78"/>
    <dbReference type="STRING" id="747525.W4KM78"/>
    <dbReference type="GeneID" id="20666740"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_121207"/>
    <dbReference type="eggNOG" id="ENOG502SIW4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009122_0_0_1"/>
    <dbReference type="InParanoid" id="W4KM78"/>
    <dbReference type="OrthoDB" id="3239511at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="883" mass="101297" checksum="F7DC8106403082C4" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4KME3</accession>
    <name>W4KME3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_244643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540840.1">
        <property type="nucleotide sequence ID" value="XM_009542545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KME3"/>
    <dbReference type="GeneID" id="20669063"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_244643"/>
    <dbReference type="HOGENOM" id="CLU_2740416_0_0_1"/>
    <dbReference type="InParanoid" id="W4KME3"/>
    <dbReference type="OrthoDB" id="10052321at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021036">
        <property type="entry name" value="Ribosomal_mS45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S35, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12298">
        <property type="entry name" value="Bot1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="61" mass="7090" checksum="566C1F2747B91937" modified="2014-03-19" version="1" fragment="single">LNPSFQPPTPVSESIRNTLYRQFMANPETNSVRNLASRYHLSIKRVEAILRLKGLEAHWIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMS4</accession>
    <name>W4KMS4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Esterase/lipase/thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_58654</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540377.1">
        <property type="nucleotide sequence ID" value="XM_009542082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMS4"/>
    <dbReference type="STRING" id="747525.W4KMS4"/>
    <dbReference type="GeneID" id="20678443"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_58654"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020372_0_0_1"/>
    <dbReference type="InParanoid" id="W4KMS4"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000252">
        <property type="entry name" value="Related to calmodulin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF26">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="218"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="486"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="622"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="487"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW86680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="645" mass="71447" checksum="9484716264604454" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMU2</accession>
    <name>W4KMU2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Eukaryotic integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_468813</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540976.1">
        <property type="nucleotide sequence ID" value="XM_009542681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMU2"/>
    <dbReference type="STRING" id="747525.W4KMU2"/>
    <dbReference type="GeneID" id="20677255"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_468813"/>
    <dbReference type="eggNOG" id="KOG2890">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043563_1_1_1"/>
    <dbReference type="InParanoid" id="W4KMU2"/>
    <dbReference type="OrthoDB" id="73612at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000004">
        <property type="entry name" value="Transmembrane protein 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
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        <property type="entry name" value="TMEM115/Pdh1/Rbl19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377">
        <property type="entry name" value="PLACENTAL PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08551">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01160">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="297"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW87024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="38916" checksum="95F406B1D5F510CE" modified="2014-03-19" version="1">MAILSSPLQLIASVPPVTRFFTAATAISSLFYFWLRWQGGNSFSAPYLVLIPGASIFYPWTFFTSVFIETSVVELIVSLIVVPPCLRYLERLWGAVETIKFIVVSVTFSNIIAFGLNWIEFIALRNADLLLYGMQYHGQMALQVAILVAFTQLIPEHQVQLFGVLKARVKTLPMAYVTFSTVMCIIGFQCPYIVIQFGFFVGWIWLRFYKKNAADVVGGDSYGDRSETFAFVYWFPPPLHTPITLLSNVVYKYASRFHLIPGGGADLENNGYALPGSARAEAERRRAMALKALDQRMANSSAPGGSSGASAPRPPPAAASSEPGGPPMPSSPVRSNSGSIGSVDLGKGKAREDATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W4KP90</accession>
    <name>W4KP90_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Clp R domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_469054</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ClpA/ClpB family.</text>
    </comment>
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        <property type="protein sequence ID" value="ETW87205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541135.1">
        <property type="nucleotide sequence ID" value="XM_009542840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KP90"/>
    <dbReference type="FunCoup" id="W4KP90">
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    </dbReference>
    <dbReference type="STRING" id="747525.W4KP90"/>
    <dbReference type="GeneID" id="20677274"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_469054"/>
    <dbReference type="eggNOG" id="KOG1051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_2_1"/>
    <dbReference type="InParanoid" id="W4KP90"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="entry name" value="Clp, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF18">
        <property type="entry name" value="HEAT SHOCK PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="Double Clp-N motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="9">
        <location>
            <begin position="2"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW87205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="907" mass="100223" checksum="7218A9F3CDBF0F90" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPC4</accession>
    <name>W4KPC4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome maturation protein SDO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_305676</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541534.1">
        <property type="nucleotide sequence ID" value="XM_009543239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPC4"/>
    <dbReference type="FunCoup" id="W4KPC4">
        <property type="interactions" value="477"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KPC4"/>
    <dbReference type="GeneID" id="20669343"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_305676"/>
    <dbReference type="eggNOG" id="KOG2917">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043216_1_1_1"/>
    <dbReference type="InParanoid" id="W4KPC4"/>
    <dbReference type="OrthoDB" id="10253092at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1250.10:FF:000001">
        <property type="entry name" value="SBDS, ribosome maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018023">
        <property type="entry name" value="Ribosome_mat_SBDS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046928">
        <property type="entry name" value="SDO1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20268">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01267">
        <property type="entry name" value="UPF0023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="9">
        <location>
            <begin position="14"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="10">
        <location>
            <begin position="109"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS C-terminal" evidence="11">
        <location>
            <begin position="174"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW87662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="253" mass="27643" checksum="B087B8329B32F88F" modified="2014-03-19" version="1">MPINQPSNQIKLTNVSVVRLKKGGKRFEIACYKNKVQEWRNGVESDLDDVLQISNVFVNVSKGEVAKAGDLKKAFGTADTAAVVKEILSKGDLQVGEKERDHDLSALRREIATLVAEKCVDPATQAPYSVSIIEKAMTEAGYSVRPGKNAKSQVSECIKLLQSDSTLPIQRARMRVRATLPAADAPKLRAQILACAETVEREDAPAEQQQEWSATLLIDPANFRVLTELLNKECKGRGRIETIAFAATATSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPJ6</accession>
    <name>W4KPJ6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Pectinesterase</fullName>
            <ecNumber evidence="4 11">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_24532</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in maceration and soft-rotting of plant tissue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pectinesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="4 11"/>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540263.1">
        <property type="nucleotide sequence ID" value="XM_009541968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPJ6"/>
    <dbReference type="STRING" id="747525.W4KPJ6"/>
    <dbReference type="GeneID" id="20669081"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_24532"/>
    <dbReference type="eggNOG" id="ENOG502QSQ4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012243_1_0_1"/>
    <dbReference type="InParanoid" id="W4KPJ6"/>
    <dbReference type="OrthoDB" id="2019149at2759"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000014">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033131">
        <property type="entry name" value="Pectinesterase_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF127">
        <property type="entry name" value="PECTINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00503">
        <property type="entry name" value="PECTINESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Pectinesterase catalytic" evidence="12">
        <location>
            <begin position="17"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW87737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="312" mass="33019" checksum="945F11A840CFB181" modified="2014-03-19" version="1" fragment="single">SSRTSPPSGAKIVRINTTTSGEYATLAAAVAALPSDSSSQIIFIYPGTYNGQVNIQRSGPVTLLGYTTDPGNYSANQVNLVASVPASTAGSNDASGTLRIHTNGAKIYNINIRNNFGQGSQAIALSQYGNQVGVYACGLFGFQDTLLANQGTQVYLQSYIEGATDFIFGRLGQAYFEGNTIGVKSNGWVTASGREADNVAIYVFNRNNIILAPNPGSTSAIYLGRPWGDYARVIFKNTYVTAPLNKGIWSIWNTGDERTDNVLFADYNTTGPGVPSGASRPSFVTVFNASQASAYNISTAVGSSSWVDANYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KS03</accession>
    <name>W4KS03_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_305556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541693.1">
        <property type="nucleotide sequence ID" value="XM_009543398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KS03"/>
    <dbReference type="GeneID" id="20669335"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_305556"/>
    <dbReference type="HOGENOM" id="CLU_2942012_0_0_1"/>
    <dbReference type="InParanoid" id="W4KS03"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="60" mass="7105" checksum="28A3299A14D68DD7" modified="2014-03-19" version="1">MVTSAVRGRNTRPNAVSPYDKRQRHPGRSLDVKMVEEKMRGRPKKEDRIDETDILDQRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMB3</accession>
    <name>W4JMB3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_456254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553185.1">
        <property type="nucleotide sequence ID" value="XM_009554890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JMB3"/>
    <dbReference type="GeneID" id="20676722"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_456254"/>
    <dbReference type="HOGENOM" id="CLU_1343418_0_0_1"/>
    <dbReference type="InParanoid" id="W4JMB3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW74692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="204" mass="22746" checksum="5B77110822E113AD" modified="2014-03-19" version="1">MEQHSPSLPSATLDDLDDVGTEFATQQAMTLQARPSLRERVNNTLEINVRGRTKTRNAVLPVRAVTPRLHRRNTAEVEIDEHLSRLGQGLFVGFILKGRPLPSNIPIIAHYKDDSGREFTHTVCVLTAEEALALKVFDKRTYGATKTCEHQLWLTLKQEKEEGAIKAHKEGMNAVGLTTEQMVSAMKFIQSASLSAGMPEMYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMR1</accession>
    <name>W4JMR1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Eukaryotic translation initiation factor 4G1 eIF4E-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_456359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553312.1">
        <property type="nucleotide sequence ID" value="XM_009555017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JMR1"/>
    <dbReference type="STRING" id="747525.W4JMR1"/>
    <dbReference type="GeneID" id="20676735"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_456359"/>
    <dbReference type="HOGENOM" id="CLU_882958_0_0_1"/>
    <dbReference type="InParanoid" id="W4JMR1"/>
    <dbReference type="OrthoDB" id="514777at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.30">
        <property type="entry name" value="eIF4G, eIF4E-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022745">
        <property type="entry name" value="eIF4G1_eIF4E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036211">
        <property type="entry name" value="eIF4G_eIF4E-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12152">
        <property type="entry name" value="eIF_4G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101489">
        <property type="entry name" value="Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Eukaryotic translation initiation factor 4G1 eIF4E-binding" evidence="2">
        <location>
            <begin position="243"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW74837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="315" mass="33181" checksum="DBA6A9F58D326247" modified="2014-03-19" version="1">MNTFSSAVPSKSAWARGPPRTILATSSSQQPPRPPSATPGAAANLRSTHPRRSRAPAEGVSIQHGLSVPRSTSAAKPVTFGSIDDAPTPTPASLLAWSRPPKAVLSAGKPRARLARSTPHPQPPRTRAGSTARTLAPVWAPRAAPIAADVVPQGAGHAMPAEQLIPCVLEWDQHAEQGPLLPPHRNTASPSYAANATVRPGPSPRRLSAHAPAFVPSELEPSLEYRVHAGPAAVTRPLSAPRTPSALATARFIDDIKAIPYPAGVRRPLAALNRNAQKGKFRYDRAFLLQFASLCVDMPDGLPAALDALRLAPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNK8</accession>
    <name>W4JNK8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_332353</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553145.1">
        <property type="nucleotide sequence ID" value="XM_009554850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNK8"/>
    <dbReference type="STRING" id="747525.W4JNK8"/>
    <dbReference type="GeneID" id="20671725"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_332353"/>
    <dbReference type="eggNOG" id="ENOG502SNY2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042941_8_3_1"/>
    <dbReference type="InParanoid" id="W4JNK8"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW74650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="171" mass="19352" checksum="882CC66EDB6094EB" modified="2014-03-19" version="1" fragment="single">YLGHDHPRELPIGNLRTVNMAFRDDPEHFAFSGIQAWAEWNAIRPPAGGYVYLGQTYLPLSVSMWHELHCLNHIRTIIVVGDDGSDHTEHCFHYIRQHILCAADTTLEPRTQGGKGVIPGEGVAHTCRDWKQVESWTEERHSTWTPEMAARLKESSPVMNKTTEGGERVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4JP28</accession>
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        </recommendedName>
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        <name evidence="3" type="ORF">HETIRDRAFT_412747</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JP28"/>
    <dbReference type="STRING" id="747525.W4JP28"/>
    <dbReference type="GeneID" id="20673063"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_412747"/>
    <dbReference type="eggNOG" id="ENOG502SQEP">
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    </dbReference>
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    <dbReference type="InParanoid" id="W4JP28"/>
    <dbReference type="OrthoDB" id="3251728at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="277"/>
        </location>
    </feature>
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        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW74825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="293" mass="33512" checksum="83816BB475BEEA58" modified="2014-03-19" version="1">MANLYPGWMPYPYPPYYQFPPTPGNARREWQAGGRSPGHANIPLPPFAPGQDYPPYPYEPFPRGRRRSFDASYLHPNQWPHWNPQPPPPNPPPSPYHTSPYSWLFHPPPLPQPQIHTLFNGDSPSQYLLFDLSAYTLTARRRINATQAVAVTPYDLDQPASNPEITRLLIVCDAIPQWKLDLHVTSAGLLPARRERPAIPFITVGDVLHGLHVHLHVPVTHEEWGQLSSSQETDVSRAYTKRYKAYPPLQQQQQREGVKRVDFLLRNHYFKGLVWASPENGVERMKLLVGSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
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    <name>W4JPK1_HETIT</name>
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        <recommendedName>
            <fullName evidence="2">DUF4100 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_423171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPK1"/>
    <dbReference type="GeneID" id="20673875"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_423171"/>
    <dbReference type="eggNOG" id="ENOG502SRIE">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003921_7_2_1"/>
    <dbReference type="InParanoid" id="W4JPK1"/>
    <dbReference type="OrthoDB" id="3252634at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF4100"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13352">
        <property type="entry name" value="DUF4100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4100" evidence="2">
        <location>
            <begin position="350"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW75502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="735" mass="82066" checksum="8560E5EC9F2FF912" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQG5</accession>
    <name>W4JQG5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_430620</name>
    </gene>
    <organism evidence="6 7">
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        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="22463738"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ATG13 family. Fungi subfamily.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009554287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQG5"/>
    <dbReference type="STRING" id="747525.W4JQG5"/>
    <dbReference type="GeneID" id="20674466"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_430620"/>
    <dbReference type="eggNOG" id="KOG4573">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011810_0_0_1"/>
    <dbReference type="InParanoid" id="W4JQG5"/>
    <dbReference type="OrthoDB" id="70161at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040182">
        <property type="entry name" value="ATG13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018731">
        <property type="entry name" value="Atg13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430:SF4">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10033">
        <property type="entry name" value="ATG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 13 N-terminal" evidence="5">
        <location>
            <begin position="13"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="151"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="315"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="892"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="315"/>
            <end position="354"/>
        </location>
    </feature>
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            <begin position="445"/>
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            <begin position="471"/>
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            <begin position="493"/>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW75131.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
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    <sequence length="977" mass="100720" checksum="02402EA9E7E87D76" modified="2014-03-19" version="1"> </sequence>
</entry>
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    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <location>
            <position position="173"/>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
    </protein>
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    </gene>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:19721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="EC" id="1.14.19.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="16">Expected to bind 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="16"/>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009553874.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="W4JQW8">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JQW8"/>
    <dbReference type="GeneID" id="20675436"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_442317"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027359_3_1_1"/>
    <dbReference type="InParanoid" id="W4JQW8"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000004">
        <property type="entry name" value="Acyl-CoA desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001522">
        <property type="entry name" value="FADS-1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00476">
        <property type="entry name" value="FATTY_ACID_DESATUR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15 16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 16" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="4 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="19">
        <location>
            <begin position="373"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ETW75933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="484" mass="54659" checksum="7AC18D30BCCA26C5" modified="2014-03-19" version="1">MSTVYPSRETPPPDVAPFTPPLTPPQSKAAALGADAPADMNVPDNYVDYTLKTTKALPPVTWENWWKELNYISLAVLTVTPLIAVYGAFTTKLRWETAAFAVFYYFVTGLGITAGYHRFWAHRSYNASKPLQYFLAAAGAGAVEGSIKWWSRGHRAHHRYTDTELDPYNAHKGLWWSHVGWMIVKPRRKPGVADVSDLSKSDIVRWQHRWYIWLIFGMGFGVPTLIPGLLWGDWRGGYVYAGAARLCFVHHSTFCVNSLAHYLGEAPFDDKHTPRDHLVTALVTIGEGYHNFHHQFPMDYRNAIKWYQYDPTKWFIALCGMLGLASHLKTFPDNEVKKGQLTMQLKRLRDTQDGLEWPQETQELPIISWQSFQEQSEKRPLVLISGFIHDVASFIDEHPGGRHLLVKNIGKDATTAFFGGVYDHSNAAHNLLSMMRVGILHGGQPHGLEEKSVPPSQRLRVARHNELSSPYSSTAYSDGEGMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4JR61</accession>
    <name>W4JR61_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_461086</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat NOL10/ENP2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="ETW75949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552184.1">
        <property type="nucleotide sequence ID" value="XM_009553889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JR61"/>
    <dbReference type="FunCoup" id="W4JR61">
        <property type="interactions" value="768"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JR61"/>
    <dbReference type="GeneID" id="20677137"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_461086"/>
    <dbReference type="eggNOG" id="KOG2321">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009923_0_0_1"/>
    <dbReference type="InParanoid" id="W4JR61"/>
    <dbReference type="OrthoDB" id="273340at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056551">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040382">
        <property type="entry name" value="NOL10/Enp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056550">
        <property type="entry name" value="NOL10_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23098">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23097">
        <property type="entry name" value="NOL10_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nucleolar protein 10-like N-terminal" evidence="9">
        <location>
            <begin position="8"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 10-like second" evidence="8">
        <location>
            <begin position="406"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="7">
        <location>
            <begin position="542"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="565"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="609"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="626"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="658"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="674"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="689"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="734"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW75949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="789" mass="86599" checksum="C9BECD677A4D4E5D" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4JR76</accession>
    <name>W4JR76_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_108055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552796.1">
        <property type="nucleotide sequence ID" value="XM_009554501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JR76"/>
    <dbReference type="GeneID" id="20666308"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_108055"/>
    <dbReference type="HOGENOM" id="CLU_120576_0_0_1"/>
    <dbReference type="InParanoid" id="W4JR76"/>
    <dbReference type="OrthoDB" id="8955945at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW75371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="195" mass="22933" checksum="F2AC270A032138B7" modified="2014-03-19" version="1">MDKIYDKEVQPKDTIQDWINTACEIDGRLRARSAQKAILANSTSFRSDYLNRFHTQQAVRYNSTTAPRRMNNQVVDMDIDATRKRNAEKAFAQFEETRRDAWVRQGEETARLIWKEKTTHPLWETKQEYIEEWRQRMFIATTSGYHNLVLRWNVLTLPHPDDPKRTMGNALCYLTDDGETEASVILLESEQCSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSG7</accession>
    <name>W4JSG7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_412280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552278.1">
        <property type="nucleotide sequence ID" value="XM_009553983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSG7"/>
    <dbReference type="GeneID" id="20673013"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_412280"/>
    <dbReference type="HOGENOM" id="CLU_3032619_0_0_1"/>
    <dbReference type="InParanoid" id="W4JSG7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="55" mass="6431" checksum="FE557729DF0EA247" modified="2014-03-19" version="1" fragment="single">MMQMDVDGGVLIAQKTDNRKQEEHKQEQQMERTRSTTLSNRVIFTGLWEHACAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSI6</accession>
    <name>W4JSI6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_105982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551419.1">
        <property type="nucleotide sequence ID" value="XM_009553124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSI6"/>
    <dbReference type="GeneID" id="20666124"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_105982"/>
    <dbReference type="HOGENOM" id="CLU_1170776_0_0_1"/>
    <dbReference type="InParanoid" id="W4JSI6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="237" mass="26847" checksum="BEABBEE18B353B68" modified="2014-03-19" version="1">MAAQFEEELLNSLPAKHGPMLKRREKASEHFEVVSSKKRHTAAVSSRDGGRWDVIGSKIRYRDRETCQVMEASVIDARSSVVCKSEYPSVMPADGNADSCREFYRKCDAILALPSTDDEKYIIRFRVWPIRGGSPKRQDSRRFWEDLGDVVILKYLAAAAATQFMMDFEIRKATGNGGKRFEVVGKNIQYEDRRMSQVREASVLDAGSSVVQGDYYRIQNSEGQQNTIAMEEVISTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSJ1</accession>
    <name>W4JSJ1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_480661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551424.1">
        <property type="nucleotide sequence ID" value="XM_009553129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSJ1"/>
    <dbReference type="GeneID" id="20677926"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_480661"/>
    <dbReference type="HOGENOM" id="CLU_2542843_0_0_1"/>
    <dbReference type="InParanoid" id="W4JSJ1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="83" mass="9035" checksum="22772B63E7D4E4C6" modified="2014-03-19" version="1">MTKTTSTVRGITSRHVLRHKVQVKSTSDLERTAKLGFPPLDSDATDQGLKSMSWPATRIHTLPPHPSPIAPFPYPSGSADART</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSN5</accession>
    <name>W4JSN5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CNNM transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_421928</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551370.1">
        <property type="nucleotide sequence ID" value="XM_009553075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSN5"/>
    <dbReference type="STRING" id="747525.W4JSN5"/>
    <dbReference type="GeneID" id="20673763"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_421928"/>
    <dbReference type="eggNOG" id="KOG2118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011310_2_0_1"/>
    <dbReference type="InParanoid" id="W4JSN5"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Unplaced genomic scaffold supercont1.12, whole genome shotgun sequence"/>
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            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="881" mass="93289" checksum="7AB66A93FC3BEF7E" modified="2014-03-19" version="1"> </sequence>
</entry>
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
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                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
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            </authorList>
            <dbReference type="PubMed" id="22463738"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        </source>
    </evidence>
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</entry>
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        <submittedName>
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        </submittedName>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
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                <person name="Durling M."/>
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                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
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                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
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                <person name="Kues U."/>
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                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">TC 32-1</strain>
        </source>
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    </comment>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M48" evidence="7">
        <location>
            <begin position="199"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW76366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="389" mass="43315" checksum="6599CFB030EC9FAC" modified="2014-03-19" version="1">MFSLFSQRTARTVYLITSRSVSAKGTSRLQTREQLPRCPIRLTSHQFSSSSPQHARYSRFSSSSDEQKSWSVSLETRLAAVGAGCAGLYIVFHLERVPETGRLRFMSVSPESEKKLGEKTYQQVLASYKGRILPSNHPVTQEIHEITTRILDANNLGYVRSTGQESPQYLKSAPVEIFSQMEDLWDPDTEREKGSSSQALTHREWNLIVVGDNKITNAMAFPGSIVVFTGILPVCGTKDGLAAVLGHEIGHVVARHVAEKYSYGQIVFAAAMLLDFLQIPLSSMLVTLLMELPHSRKQEHEADAIGLRLSSKACFDPRAAPEFFVRIDQLEKSSKNFSTEFLSTHPMSQTRVRSLIEQLPNAYALQAASSTCGDLQDHIPNFKSVSSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUJ3</accession>
    <name>W4JUJ3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_125561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550754.1">
        <property type="nucleotide sequence ID" value="XM_009552459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUJ3"/>
    <dbReference type="STRING" id="747525.W4JUJ3"/>
    <dbReference type="GeneID" id="20666911"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_125561"/>
    <dbReference type="eggNOG" id="KOG0703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027009_1_0_1"/>
    <dbReference type="InParanoid" id="W4JUJ3"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000026">
        <property type="entry name" value="GTPase activating protein for Arf, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF1">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="14"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW77217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="500" mass="53337" checksum="356A84D0E7213DE3" modified="2014-03-19" version="1">MSGTSKIAAERNSKAVIDLVMKPGNDICADCKTRNPRWSSHNLGIFICVNCASIHRKIGTHISKVKSLTLDSWTKEQVENMRQIGNIKSNQFYNPDEVRNPPPTNMVDSERDSELEKFIRDKYEFKKFVSRSAIVAAHLGPSRSAASVKALPSSSPQRSQTAPLGNPTASSARPLTSSQTLPQIPSTATPPSTFQHSLPNRSATQPPSAFQQQQQAQQMQQPASGVWSDLAALQGPAQNSSLPLQYQTSQPLALPNHNPFPTAGTTPFGNGMGLSPGTNATGISPHLAVGGGMGMGPGISSGLSMNNMGTPPFQTQPQMQTQAQSASFGAPNTFSSAGTGAANPFAQMLAAQSHAQGQMQMQQPFQSQPFAPQQNPFPQPTPTFLQQQPTSFQPQPTAFAPSPQPFAPQSQANPFYTAGQPMLAQSQAPFRTTPSPYGGMGVGTQFQPQQSQPQQMFAAQGMQQQSPMPMQGTNPFTGWMQQAAPAQGGFTGQNGPWGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUQ5</accession>
    <name>W4JUQ5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_327143</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550756.1">
        <property type="nucleotide sequence ID" value="XM_009552461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUQ5"/>
    <dbReference type="FunCoup" id="W4JUQ5">
        <property type="interactions" value="159"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JUQ5"/>
    <dbReference type="GeneID" id="20671300"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_327143"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_2_8_1"/>
    <dbReference type="InParanoid" id="W4JUQ5"/>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF14">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="98"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="524"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="206"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="433"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW77219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="704" mass="79220" checksum="81791AA1305D4C23" modified="2014-03-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUX4</accession>
    <name>W4JUX4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_243985</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550851.1">
        <property type="nucleotide sequence ID" value="XM_009552556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUX4"/>
    <dbReference type="FunCoup" id="W4JUX4">
        <property type="interactions" value="172"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JUX4"/>
    <dbReference type="GeneID" id="20669022"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_243985"/>
    <dbReference type="eggNOG" id="KOG4431">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087356_3_0_1"/>
    <dbReference type="InParanoid" id="W4JUX4"/>
    <dbReference type="OrthoDB" id="6604018at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF3">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="8">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="80"/>
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        </location>
    </feature>
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            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW77332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="112" mass="12479" checksum="9FA88615BA2C9FA6" modified="2014-03-19" version="1" fragment="single">SMETYREKASRKFKQQPLVPIGTLATTAALIMAMTKLRKGQSASLNRWLRVRVVAQGFTIVAVVAGSWMYGSQKGSISHQDDAAANAQEKAKEERASFEERLKVAEETHRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>W4JV18</accession>
    <name>W4JV18_HETIT</name>
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        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">HETIRDRAFT_327516</name>
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        <lineage>
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            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_327516"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="173"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="804"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
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            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
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    </feature>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW77382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="852" mass="94467" checksum="321A039C7AFEF8FB" modified="2014-03-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JV56</accession>
    <name>W4JV56_HETIT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_421580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550956.1">
        <property type="nucleotide sequence ID" value="XM_009552661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JV56"/>
    <dbReference type="GeneID" id="20673734"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_421580"/>
    <dbReference type="HOGENOM" id="CLU_2391902_0_0_1"/>
    <dbReference type="InParanoid" id="W4JV56"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW77453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="89" mass="10068" checksum="7090ABC35CAEB0E9" modified="2014-03-19" version="1">MITFCRALTAVYTDTIITNTKRPHKERRTNKVQIVTLVIHSQRITLSLVEYHGPIAQRAWNAALQTTHTSGIELLVVPGRKETNGETQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVL5</accession>
    <name>W4JVL5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_454505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550666.1">
        <property type="nucleotide sequence ID" value="XM_009552371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JVL5"/>
    <dbReference type="GeneID" id="20676527"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_454505"/>
    <dbReference type="HOGENOM" id="CLU_2097189_0_0_1"/>
    <dbReference type="InParanoid" id="W4JVL5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW77120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="116" mass="12459" checksum="243603017D54569D" modified="2014-03-19" version="1">MARAATTSLLPCLLSPPPSTTASARARLISPPMPSSATPFARACLLRRACACLLLSRHRRRPTPPLSVLVQDKHMPVLLPPSPPALILYDEYKHGLASFGLAAAAHHHHLCPRSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVY0</accession>
    <name>W4JVY0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_441359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549742.1">
        <property type="nucleotide sequence ID" value="XM_009551447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JVY0"/>
    <dbReference type="GeneID" id="20675355"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_441359"/>
    <dbReference type="HOGENOM" id="CLU_1713516_0_0_1"/>
    <dbReference type="InParanoid" id="W4JVY0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="153" mass="16929" checksum="1C65F7007C7C4655" modified="2014-03-19" version="1">MGLEWNGACSRSRSRVWRASELAQGQGARARRVGRLLPRAWRRGFVVERCRARVGTDDEGALMAVRGAHSPVAAGMPPSSHIRRYAEPTRLPARRHLDASPRAEAPVRPTSFSFPRDDQDPGPSPRTYAQRDIATIQGDVCMCSTCTKYVLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWG2</accession>
    <name>W4JWG2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_453980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549904.1">
        <property type="nucleotide sequence ID" value="XM_009551609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWG2"/>
    <dbReference type="GeneID" id="20676456"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_453980"/>
    <dbReference type="HOGENOM" id="CLU_1532761_0_0_1"/>
    <dbReference type="InParanoid" id="W4JWG2"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="175" mass="19314" checksum="224D89861A8314E3" modified="2014-03-19" version="1">MYLVMIVCMYARTLFPGSYLRGKAVRASTCEHWASASSFKLRVASRRARAALTARAITSRGLLPRRRRRRRRDSSSGNHPLRHPRHQVPVAQSNRNPAASPPTTSNEPAVLHHLDFVQCTLRHAAGTGARAAHSTSPPFDPTTSHGSTRVPSKPSKPQAHPRFEVFGLVQLRASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4JX48</accession>
    <name>W4JX48_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphodiesterase</fullName>
            <ecNumber evidence="3">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_164096</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
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                <person name="Cullen D."/>
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                <person name="van Diepen L.T."/>
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                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="155" mass="17244" checksum="B215447261229C62" modified="2014-03-19" version="1">MLFKSRGPSQLRGLGATIEFKFRDKCVSGINRFHHFRGGLLCIDVSDVRCRAGWCADTLNSRSAPLRVKRGARNPARTIRQGAYRNCVLHCAPPTPCESMNREPPGYISACLSLTSSVHACGRSVIYISHFLSRMSSSFRSGREMPPAQHFSQID</sequence>
</entry>
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                <person name="Broberg A."/>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Lin Y.C."/>
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    </evidence>
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</entry>
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                <person name="Cullen D."/>
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                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
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                <person name="Lin Y.C."/>
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                <person name="Lindquist E."/>
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                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550249.1">
        <property type="nucleotide sequence ID" value="XM_009551954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXR5"/>
    <dbReference type="STRING" id="747525.W4JXR5"/>
    <dbReference type="GeneID" id="20667905"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_164248"/>
    <dbReference type="eggNOG" id="KOG1165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_983721_0_0_1"/>
    <dbReference type="InParanoid" id="W4JXR5"/>
    <dbReference type="OrthoDB" id="3265205at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="283" mass="31774" checksum="AB99D3EBCD232319" modified="2014-03-19" version="1">MLYIKPFTLINNRYSIRYLEESGGQGSVRLAMDTQLETWVAVKISPVDSGASQEGDVYAKLGPQPGFLAVLWSGTQDGVHLLVMDRLLCTLHKFLDFALLKRIRLPAEDIMAAIAFTLSPLRILHEHGFVHCDITPFNIGYKNARPHHPLCLFDLASAVPYVDSDGCHVEWQEVDGRTLYLSSEFSSVNIQLGQTPSRRNDLESLAYTAAYALRYPKPLPWSHLCNLFGADRKIARMKKECSNSELFGAFSCFALLLDYARGLGFTEEPDYDYLIGAFQSALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYS6</accession>
    <name>W4JYS6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-phosphate beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_410699</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:15401"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15402"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.117" evidence="4"/>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549032.1">
        <property type="nucleotide sequence ID" value="XM_009550737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYS6"/>
    <dbReference type="FunCoup" id="W4JYS6">
        <property type="interactions" value="444"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JYS6"/>
    <dbReference type="GeneID" id="20672890"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_410699"/>
    <dbReference type="eggNOG" id="KOG2977">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_9_1_1"/>
    <dbReference type="InParanoid" id="W4JYS6"/>
    <dbReference type="OrthoDB" id="3784at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004581">
        <property type="term" value="F:dolichyl-phosphate beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="13">
        <location>
            <begin position="64"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW78717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="313" mass="34362" checksum="EF35ECD2CF37B499" modified="2014-03-19" version="1">MDQNLLLCGGLLVTAILLAYVALHAWTPPPIVEHASEKNYRSRSSPKSAKPLPSLHDIASIDITVVIPAYNETARLPSMLDTAVTYLAAQKGRTYEILIVDDGSSDGTADKALAMAKGYPRADIRVVQLEKNLGKGGAVRHGMLHGRGEKLLMVDADGASRFEDLALLWNALDGIGRKGVAIGSRAHLVKTAAVVKRSFIRNFLMYGLHTVLRIVGVGHIRDTQCGFKLFTRAAAQQIFPNQHLTTWIFDVELLLLAKQLGIPVEEVPIEWHEVPGSKLNVMKDSLQMLRDLLVLRANMLLGRWKIGLKAKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZ90</accession>
    <name>W4JZ90_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CNNM transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_326350</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550373.1">
        <property type="nucleotide sequence ID" value="XM_009552078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZ90"/>
    <dbReference type="FunCoup" id="W4JZ90">
        <property type="interactions" value="273"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JZ90"/>
    <dbReference type="GeneID" id="20671232"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_326350"/>
    <dbReference type="eggNOG" id="KOG2118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011310_0_3_1"/>
    <dbReference type="InParanoid" id="W4JZ90"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000006">
        <property type="entry name" value="DUF21 and CBS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF97">
        <property type="entry name" value="METAL TRANSPORTER CNNM-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845057" description="CNNM transmembrane domain-containing protein" evidence="9">
        <location>
            <begin position="17"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="10">
        <location>
            <begin position="36"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="398"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW78400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="443" mass="48224" checksum="254576B5407240FC" modified="2014-03-19" version="1">MILSAAIFSLISSVNAFPFLNAAFAEPIAEDPEPVGSTQFWWKLAISIVLVLSGGVFAGLTLGLMGLDELHLRVLATSSEDMKEKANAQKVLKLLGKGRHWVLVVLLLANVIVNESLPIFLDKAIGGGIAAVAISTFMIGAVIPQAVSVRYGLSIGAACAPIVLTFMYLFAPIAWPIAKLLDYVLGHNEISTYKKAELKSFLQFHRSGEEPLRDDEISILNGVLELNTKNVETIMTPMKARPHDVLTLASDAIMDSKTVEHILTSGYSRFPVHEPGNPFSFIGLLLVKKLLSYDPAQCWPVSKFQLGILPEAKPSINCFQALDYFQTGRAHLLLISTTPGMAGGAIGVITLEDIIEEIISEEIVDETDRYEDNQNKQRAKRMTNATIMRGIVERERRVDSANTSIGERTPLIAQSPPSEQNGVSSVASRLQYGTAVLSQSPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4K070</accession>
    <name>W4K070_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA polymerase III subunit Rpc25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_324290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549047.1">
        <property type="nucleotide sequence ID" value="XM_009550752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K070"/>
    <dbReference type="FunCoup" id="W4K070">
        <property type="interactions" value="435"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K070"/>
    <dbReference type="GeneID" id="20671040"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_324290"/>
    <dbReference type="eggNOG" id="KOG3297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073901_1_1_1"/>
    <dbReference type="InParanoid" id="W4K070"/>
    <dbReference type="OrthoDB" id="10256606at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04330">
        <property type="entry name" value="RNAP_III_Rpc25_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III subunit Rpc25" evidence="7">
        <location>
            <begin position="83"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW78735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24867" checksum="8BEAADF12566CA36" modified="2014-03-19" version="1">MFVLSLIKDTIPIHPSHFGVPPEQALINELNKKFANRVLHDVGLCICVFDISEAGEGKVRYGDGFLWYTVIFRLTVFRPFPSEVILARVKSSDEDGIQLSVGFFEDMWIPITYLPQPTAFDPNERAHFWLPGSQSTSTHELLDSPTSERMYIDQGETVRVRVETDEFYDDEPGPPKATEGVQIKVESRRPPYTITCSIAEQGLGPVAWWRTTEADAMDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0I1</accession>
    <name>W4K0I1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_104172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549125.1">
        <property type="nucleotide sequence ID" value="XM_009550830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0I1"/>
    <dbReference type="GeneID" id="20665973"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_104172"/>
    <dbReference type="HOGENOM" id="CLU_912339_0_0_1"/>
    <dbReference type="InParanoid" id="W4K0I1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="305" mass="32913" checksum="4B6BDA2E354C5430" modified="2014-03-19" version="1">MAFARPRVGRPRAVLRPTTPDAVFAHRPRRSANFHRGDARATWARLHRVSQLGEAGLVVPMPQSRYAPTLSPSALRIACGLTADHRYMLRRSGERTGQTGALSRWDSVRERGPAIASSRAIHSDTLLFPPKRTPAHASSIFALRVSDGPHTTAGRVRVSLRIRVPPRSSVAAPRPLPRLHCSFLDLDTGAKVVASTFFRFALAAAHMRSRNDHAGPVWPPSHVSTPSGPRPHPARAAEHESNRTLNGNSTVNIDVGISPYTPAYPAQAMCTPPKAQPLSVHAPLTSAVGTTLVSVALMPSSSTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0N1</accession>
    <name>W4K0N1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_324439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549616.1">
        <property type="nucleotide sequence ID" value="XM_009551321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0N1"/>
    <dbReference type="GeneID" id="20671052"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_324439"/>
    <dbReference type="HOGENOM" id="CLU_1906981_0_0_1"/>
    <dbReference type="InParanoid" id="W4K0N1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="163" mass="17129" checksum="282D45493E84BB5D" modified="2014-03-19" version="1">MISCPLAHRPARPHRPHRLAHRMRCPDPRSSHPHLPLDVALAYSLQLDTTHHPGTSSASSTFVNTSASDASSTVTTTTTAASASSTSSRRSSESLRTMPSANRRDRDRTSQDRSKSMSAASTAHIRGALLDQASAAASASASSRTGRPCLPPASRPPSPLAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0R1</accession>
    <name>W4K0R1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_459913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549031.1">
        <property type="nucleotide sequence ID" value="XM_009550736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0R1"/>
    <dbReference type="GeneID" id="20677030"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_459913"/>
    <dbReference type="eggNOG" id="ENOG502RZMU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042688_1_1_1"/>
    <dbReference type="InParanoid" id="W4K0R1"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW78716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="19765" checksum="14D89416FE550AFB" modified="2014-03-19" version="1">MTRYYKEVEKLLKKHTGAKRVFVFDHIIRRPVVEGSESGQNPPLRGPVTRVHADQTYVAGEKRWPIENVVAHHPLAVADWRTVNPDIDLVHTRYVYRDREGSTFSVKDNPEHRWYYLGNQTSEEVTLIKCFDTDESKARLTPHSAFLDSSSPKDAPQRQSTETRCLVFDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1C6</accession>
    <name>W4K1C6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_322190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548106.1">
        <property type="nucleotide sequence ID" value="XM_009549811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1C6"/>
    <dbReference type="GeneID" id="20670822"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_322190"/>
    <dbReference type="HOGENOM" id="CLU_2688119_0_0_1"/>
    <dbReference type="InParanoid" id="W4K1C6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="74" mass="8500" checksum="48BE43A02BBF45D9" modified="2014-03-19" version="1">MANEASFVSLRIKLAWPLDFHPHLASPYMEVAQIQLCAVDFLVWCHTWQAPRPSPIPEPDSVQHGHTPQRLWEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1G4</accession>
    <name>W4K1G4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aromatic-L-amino-acid decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_322297</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548232.1">
        <property type="nucleotide sequence ID" value="XM_009549937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1G4"/>
    <dbReference type="STRING" id="747525.W4K1G4"/>
    <dbReference type="GeneID" id="20670836"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_322297"/>
    <dbReference type="eggNOG" id="KOG0628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011856_3_1_1"/>
    <dbReference type="InParanoid" id="W4K1G4"/>
    <dbReference type="OrthoDB" id="639767at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW79668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="54443" checksum="70EF574E12A5A82D" modified="2014-03-19" version="1" fragment="single">LHRFRKAGYQAIDRICDYYYSLREKPVAAQVEPGYLRKALPETAPNEGEVWQDIADDYQRLIIPGLTHWQHPSFFAYFPTACTFEGMLGDLPACTELESVVMDWAAKMFGLDSSFHNISEVGGGVIQTTASDSALTAIVAAREQYHGLYPDVPLESLLIYVTTHTHSFGKKAGRVLGLRVRALDVDAAVRTGWGLDSDVLRTCVEEDRKAGLHPFIVIATVGTTNSGAIDRIADIGATIEKDYPSIWLHVDAAWAGVTLSCPELRDRAQIKGINKYATSLCVNFHKWGLTNFDTSALWVRDRKRLTDALDVTPEYLRTKHGDAGTVIDYRNWHLSLGRRFRSLKLWFVLRSYGIEGFQAYIRKCIKMNDLFAEYVRTSNTFELVTPPSFALTVFRLVPPATASAAWTPNELNSLNRRFHNALQEHHDQLLLTQTELVGVFCMRFAVGAARTNEEDIHRAWEVIKKTGEDVLKQSTEDRNRVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2A1</accession>
    <name>W4K2A1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_242749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548477.1">
        <property type="nucleotide sequence ID" value="XM_009550182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2A1"/>
    <dbReference type="GeneID" id="20668949"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_242749"/>
    <dbReference type="HOGENOM" id="CLU_2819474_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2A1"/>
    <dbReference type="OrthoDB" id="3260546at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="67" mass="7964" checksum="173CFFB80963430B" modified="2014-03-19" version="1" fragment="single">IDTCKLWKSLTTFTDTMETFKDFCEEVYRLYSRSEEKHKWSVSDIDKLVSEISRVGILSLSRLGDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2T8</accession>
    <name>W4K2T8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome oxidase biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_147066</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548573.1">
        <property type="nucleotide sequence ID" value="XM_009550278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2T8"/>
    <dbReference type="FunCoup" id="W4K2T8">
        <property type="interactions" value="352"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K2T8"/>
    <dbReference type="GeneID" id="20667181"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_147066"/>
    <dbReference type="eggNOG" id="KOG1239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029282_6_1_1"/>
    <dbReference type="InParanoid" id="W4K2T8"/>
    <dbReference type="OrthoDB" id="2148490at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20069">
        <property type="entry name" value="5TM_Oxa1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF66">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEIN OXA1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="12">
        <location>
            <begin position="167"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW80049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="414" mass="45556" checksum="2CE84D83590A0F72" modified="2014-03-19" version="1">MNSVGILSRMQCRRLVGVRPFAPSPHARLLSTSNHQRIRPLPRPSAFAPSAKRNLWLFSSKPSAPTPPPPPQPSVPELTFEQAPPEAAVPANATSGFSEAFPADSTILLDSDLSAPIAASSSISDTLISIAPLQYGDLAALGLAHWTPSGICQWMLEIINVSTGMPWFYTIIAGTVLSRVLLLPFSVQQLRNSARLAPYQGRLLQIKDELNRSRETRDPLAMQKVALKQRKVYEEAGVSMLPMLATPFVQLPVTLGMFFAVKGLCTLPLQQLMWSGVSFLPDLTVAEPYYILPIAAAVCMNAQLTLGASDFAGDRQTMAHMINFFRVISVFSIPFMGAFPAGLNLYVLTGVLAMLLQTVVLRSSAVRRFFDIPVVPKNAGFKPVTFMESINHLKKYFREQSEMAQKKATEKRKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4K364</accession>
    <name>W4K364_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA+-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_103326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548693.1">
        <property type="nucleotide sequence ID" value="XM_009550398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K364"/>
    <dbReference type="STRING" id="747525.W4K364"/>
    <dbReference type="GeneID" id="20665894"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_103326"/>
    <dbReference type="eggNOG" id="KOG0742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004471_6_3_1"/>
    <dbReference type="InParanoid" id="W4K364"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF2">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="1">
        <location>
            <begin position="403"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="614" mass="69541" checksum="F996B5081DE40E2C" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4J6</accession>
    <name>W4K4J6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_115898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547394.1">
        <property type="nucleotide sequence ID" value="XM_009549099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4J6"/>
    <dbReference type="GeneID" id="20666502"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_115898"/>
    <dbReference type="HOGENOM" id="CLU_973372_0_0_1"/>
    <dbReference type="InParanoid" id="W4K4J6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW80674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="286" mass="32092" checksum="006BCE156ABE4A14" modified="2014-03-19" version="1">MPKSTIRIPKQGAVRRMVSHARFPTSVSSSRGLLEIVSSPSTLAAFSAIPVVSSPLTLPPCAFVAAEHLILGDRLPRSLNQRRARAQSWRTGGLISSSSSRAADGSGVQRLRLELVVKALKVRCPSDVPSSRAGWREFMGRVVLGRMSHILWYLGDAFLAELFSSSQAVSIIHTLHETQVTNIIGLALSEAATGVENRSNATNTRIAQSYHPTRLHKRHKKPIHLMHPFHWRRYPYPQERPWRWISLFSADEIGDSAMVLVFRSITYVVWSRVTKWPRSKETGWMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4Y9</accession>
    <name>W4K4Y9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DASH complex subunit DUO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Outer kinetochore protein DUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HETIRDRAFT_452301</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DUO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547500.1">
        <property type="nucleotide sequence ID" value="XM_009549205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4Y9"/>
    <dbReference type="GeneID" id="20676240"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_452301"/>
    <dbReference type="eggNOG" id="ENOG502SQ77">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_416219_0_0_1"/>
    <dbReference type="InParanoid" id="W4K4Y9"/>
    <dbReference type="OrthoDB" id="5599235at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013960">
        <property type="entry name" value="DASH_Duo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08651">
        <property type="entry name" value="DASH_Duo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="140"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="140"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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                <person name="Aerts A."/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="41"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="86" mass="9906" checksum="B4C98D6BC9CBD8B2" modified="2014-03-19" version="1">MYLPLLSDPSRRITEKIRNRLVQRSSAKLKIVEGSEPHATTVPLFQIPLELVYKILWYLGPNDLLNLSQTNKSFRAFLLGESCNVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6Z2</accession>
    <name>W4K6Z2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_320152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547787.1">
        <property type="nucleotide sequence ID" value="XM_009549492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6Z2"/>
    <dbReference type="STRING" id="747525.W4K6Z2"/>
    <dbReference type="GeneID" id="20670646"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_320152"/>
    <dbReference type="eggNOG" id="ENOG502SKD3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024804_0_0_1"/>
    <dbReference type="InParanoid" id="W4K6Z2"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="58637" checksum="77A7F5889E3ABEB4" modified="2014-03-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7K1</accession>
    <name>W4K7K1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_319278</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547731.1">
        <property type="nucleotide sequence ID" value="XM_009549436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7K1"/>
    <dbReference type="STRING" id="747525.W4K7K1"/>
    <dbReference type="GeneID" id="20670585"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_319278"/>
    <dbReference type="eggNOG" id="ENOG502S0VZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011863_1_0_1"/>
    <dbReference type="InParanoid" id="W4K7K1"/>
    <dbReference type="OrthoDB" id="775571at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF70">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="570"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="616"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="616"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW81051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="984" mass="110178" checksum="C2AE9233D2E82DEC" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7K5</accession>
    <name>W4K7K5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="5">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HETIRDRAFT_51113</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
            <dbReference type="Rhea" id="RHEA:13289"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.7.8.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.15" evidence="5"/>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009547538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7K5"/>
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        <property type="interactions" value="258"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K7K5"/>
    <dbReference type="GeneID" id="20678170"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_51113"/>
    <dbReference type="eggNOG" id="KOG2788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029942_1_1_1"/>
    <dbReference type="InParanoid" id="W4K7K5"/>
    <dbReference type="OrthoDB" id="10262326at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06855">
        <property type="entry name" value="GT_GPT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029567"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00033238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ETW81792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="478" mass="53182" checksum="D8C330A1CD006CAD" modified="2014-03-19" version="1">MANPLAPRPLPSVLLFSLVPIASWFIVRPLIEPIPALPALHVSLGLSIFALLLTLYLVPALGPTFIQANLKGKDLLKTYYNPILGLVCASIYILLLIIFIPFAFSSISLTQSHTQFTVHEGIIINEFPHYQLSVYLSSLLSLLISTLLGFLDDVFDIRWRHKLPIPIIASIPLLMVYYAEQGNTHVVVPLPLRPFFGTLVNLGPIYYLYMSLLSTFSTNSINILAGINGSEVSQALVIALSVVLNDLLYLPWPVGFRIPLHLLGSPTEVEVGGVWSAGMAYGSKELVERHLFSLYFMLPLVGVCLGFLYHNWYPARAFPGDTLCYVTGMAFSVVGIQAHFSKTLLLFFLPQIFNFLLSCPQLFGLVPCPRHRVPRFDPNANLLYPSKVQFLQRPSKLTALTLRTLSTLRLTELTIHPDTGHILEATNLTILNFLLLKLGPMQEKRLTQTLIAQQVAGSVVAFTVRYGLANLVYDGDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7S1</accession>
    <name>W4K7S1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA damage-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_317594</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546431.1">
        <property type="nucleotide sequence ID" value="XM_009548136.1"/>
    </dbReference>
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        <property type="interactions" value="782"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K7S1"/>
    <dbReference type="GeneID" id="20670432"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_317594"/>
    <dbReference type="eggNOG" id="KOG1897">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002893_0_0_1"/>
    <dbReference type="InParanoid" id="W4K7S1"/>
    <dbReference type="OrthoDB" id="433457at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="5">
        <location>
            <begin position="13"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="6">
        <location>
            <begin position="507"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="4">
        <location>
            <begin position="902"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="278"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW81833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1254" mass="136615" checksum="4F5F98626E353E03" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7Y6</accession>
    <name>W4K7Y6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_169935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547846.1">
        <property type="nucleotide sequence ID" value="XM_009549551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7Y6"/>
    <dbReference type="GeneID" id="20668249"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_169935"/>
    <dbReference type="HOGENOM" id="CLU_147768_0_0_1"/>
    <dbReference type="InParanoid" id="W4K7Y6"/>
    <dbReference type="OrthoDB" id="3245189at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="107" mass="12256" checksum="F2B58A43D439DD35" modified="2014-03-19" version="1">MSWGLEQLQVSSAVSTWGIEDVLVEEKWQQFISLLCGLLFSININWFSLTKHLCAYSTSAIYVTILNNPRSKHFLAQETLLYCVIPGPHEPTLEQLNEITRLLAKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4K887</accession>
    <name>W4K887_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Epoxide hydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_169014</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546592.1">
        <property type="nucleotide sequence ID" value="XM_009548297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K887"/>
    <dbReference type="STRING" id="747525.W4K887"/>
    <dbReference type="GeneID" id="20668197"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_169014"/>
    <dbReference type="eggNOG" id="KOG2565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019414_0_2_1"/>
    <dbReference type="InParanoid" id="W4K887"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="5">
        <location>
            <begin position="5"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW82008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="401" mass="45309" checksum="21706EF625C4EFA3" modified="2014-03-19" version="1">MSMAKAYKIAVTDEDLALLKRKLELSRFPDELEEAGWDYGAPLADIKRLAARWREGYDWRKYEAELNVLPMFTRDIAIDDHGSLNIHYVHQQSMVENAIPLLFVHGWPGSFIEVRKVISLLTASSPDHPSFHVVALSLPGYAFSEAPRNKGFSGPQYAELGHKLMLSLGYEEYVTQGGDWGHFVTRFMAYTYGPKNVKAWHTNFAAAMSPPRLFSDPRAFLSHIFSRYTPQERLALQRTAHMISNGRGYTEQQSTQPQTLGYSLSDSPIGLLAWIYEKLVAWTDAYQWEDDEVLTWISIYWFSRAGPTAATRIYYEVGKTGGFLAPPRPAIPMGVSYFPKDIYQAPRTWLRVVGNPVFVASHSEGGHFAAYERPSELVGDLRKMYARGGPAYGVVQGKDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4K897</accession>
    <name>W4K897_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_147630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546207.1">
        <property type="nucleotide sequence ID" value="XM_009547912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K897"/>
    <dbReference type="GeneID" id="20667215"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_147630"/>
    <dbReference type="HOGENOM" id="CLU_2849963_0_0_1"/>
    <dbReference type="InParanoid" id="W4K897"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="65" mass="6845" checksum="8E7990B42A783D9B" modified="2014-03-19" version="1">MVEAWRHRLPQHFAEGSAVSRGATRLAAHSPGQLGAAAEVVHRAMSGQPGVDRSIEGSDTGRRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4K898</accession>
    <name>W4K898_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_417989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546568.1">
        <property type="nucleotide sequence ID" value="XM_009548273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K898"/>
    <dbReference type="GeneID" id="20673436"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_417989"/>
    <dbReference type="eggNOG" id="ENOG502QUPU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009065_2_0_1"/>
    <dbReference type="InParanoid" id="W4K898"/>
    <dbReference type="OrthoDB" id="73076at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="550" mass="61554" checksum="2F6C1A5321BC4AFE" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8H4</accession>
    <name>W4K8H4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_36688</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERGIC family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545781.1">
        <property type="nucleotide sequence ID" value="XM_009547486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8H4"/>
    <dbReference type="FunCoup" id="W4K8H4">
        <property type="interactions" value="390"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K8H4"/>
    <dbReference type="GeneID" id="20671825"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_36688"/>
    <dbReference type="eggNOG" id="KOG2667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034705_1_0_1"/>
    <dbReference type="InParanoid" id="W4K8H4"/>
    <dbReference type="OrthoDB" id="10266265at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="9"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
        <location>
            <begin position="143"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW81650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="422" mass="46597" checksum="E84D0DF2FFF12B1B" modified="2014-03-19" version="1">MAKGLFGALKGIDAFGKTMEDVKVKTRTGALLTILSAAIILAFSTMEFFDYRRVNMDTSVVVDKSRGERLTVRMNVTFPRVPCYLLSLDVMDISGETQRDITHNIVKSRLSPTGALVNAHSAELRNEIDKINEQRQDGYCGSCYGGLPPQSGCCNSCDSVRESYVQKGWSFGNPDAIEQCVQEHWSERLQEQSTEGCNVAGRVRVNKVIGNIHLSPGKSFQSSASNIYELVPYLKNDGNRHDFSHTVHEFTFTADDEYDVNKMQKGKEMKERMGLSGNPLDGYQARTAKAQYMFQYFLKVVSTQFRTLDGQTVNTHQYSVTHFERDITTGSQGGQNEGVHIQHGTSGIPGAFFNYEISPILVVHEETRQSFAHFVTSTCAIVGGVLTVASILDSVLFATGRHLKKTGTSSSNGNGHPSGKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4K947</accession>
    <name>W4K947_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_451827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546804.1">
        <property type="nucleotide sequence ID" value="XM_009548509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K947"/>
    <dbReference type="GeneID" id="20676201"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_451827"/>
    <dbReference type="HOGENOM" id="CLU_184646_0_0_1"/>
    <dbReference type="InParanoid" id="W4K947"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="98" mass="10588" checksum="20F34CA17A65C988" modified="2014-03-19" version="1">MSSGQQQQQQHHTDPRTTPHSFHSPRSLHSPTLSSCNPSWMRLYVAGTDALASGCVCARGVLPDVLVFDSAVPQPDAPPKMYSSNSRPRADAPLPPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9C1</accession>
    <name>W4K9C1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_165232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544796.1">
        <property type="nucleotide sequence ID" value="XM_009546501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9C1"/>
    <dbReference type="STRING" id="747525.W4K9C1"/>
    <dbReference type="GeneID" id="20667971"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_165232"/>
    <dbReference type="HOGENOM" id="CLU_956626_0_0_1"/>
    <dbReference type="InParanoid" id="W4K9C1"/>
    <dbReference type="OrthoDB" id="312874at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW82432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="291" mass="33211" checksum="25AF8F1648BD906E" modified="2014-03-19" version="1">MPDIVLQGTRAFMSTEIIHSSNVRYEGTEALRSPGRVAHSAIHDLESFFWVLLYLCLTRDGPGGGRRIELSINEPLTEETKPIYAAVYCLFDSKDDHTLWNNKRLLFDNPDDLDEIILKCIHPYFDSLKPLLSRWWKILRFGYITYNDYVAGGLHDHIITLLQDELGKIQSKSNLHSNLDADEVAHMEDKTDKEIQRRKDDFEFIQLRVRQLDESLKRRSPHAGQQRLPTTPPKDSRQGSDQAPVWDSTSPKGRSQYSMYTSTDPGSPPTPPPQLKKARMGNTGAPLSGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9E7</accession>
    <name>W4K9E7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450 monooxygenase 114</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cyp114</name>
        <name evidence="9" type="ORF">HETIRDRAFT_149318</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544720.1">
        <property type="nucleotide sequence ID" value="XM_009546425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9E7"/>
    <dbReference type="GeneID" id="20667341"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_149318"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2399937_0_0_1"/>
    <dbReference type="InParanoid" id="W4K9E7"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW82354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="93" mass="10172" checksum="821DA601A811B60B" modified="2014-03-19" version="1">MLPLGTLITGDNGPPILEVFIPRDTDVICNIIGVNRNPAIWGPEATTWRPERWLEPLPPSGSDARVPGVYSNMMTFVGGARACIGFKFSELEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9K8</accession>
    <name>W4K9K8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_473694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544878.1">
        <property type="nucleotide sequence ID" value="XM_009546583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9K8"/>
    <dbReference type="GeneID" id="20677532"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_473694"/>
    <dbReference type="HOGENOM" id="CLU_2359990_0_0_1"/>
    <dbReference type="InParanoid" id="W4K9K8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="96" mass="10826" checksum="8F16C5514B005878" modified="2014-03-19" version="1">MPNGRSGQDKDIEMAPPNRSIGPCDAVIQLGQKFVSNLESVDIIHGCPTIATMRTQQRIADVIERYDARWKCWRSEAIKTVALASQCQLLRRTNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9Z0</accession>
    <name>W4K9Z0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_315073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544924.1">
        <property type="nucleotide sequence ID" value="XM_009546629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9Z0"/>
    <dbReference type="GeneID" id="20670188"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_315073"/>
    <dbReference type="HOGENOM" id="CLU_211257_0_0_1"/>
    <dbReference type="InParanoid" id="W4K9Z0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="55" mass="5879" checksum="B7F4F24F4F11E440" modified="2014-03-19" version="1">MFGQCLAQSQNCLGTIISYSLLLLNTSSSTLALEVVLVLCLSLRATSSLSFWSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4KA81</accession>
    <name>W4KA81_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carbohydrate esterase family 16 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_315263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545070.1">
        <property type="nucleotide sequence ID" value="XM_009546775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KA81"/>
    <dbReference type="GeneID" id="20670204"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_315263"/>
    <dbReference type="eggNOG" id="ENOG502SKVX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130567_0_0_1"/>
    <dbReference type="InParanoid" id="W4KA81"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="15156" checksum="B27BEFC857D8F54B" modified="2014-03-19" version="1" fragment="single">AAQDLLNQIQILASPPTNGRNFLVTDVYGRGTHTPAGEAWKQSIFDGLSAFHKGTGVPQPLNVAFGDFSRIWDGVLGSDPGYEAFGYTSTDSCAGDTTEDSCSDPKHYFYWISGHPSNETMRIMADYVEEVFVGCHLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAZ2</accession>
    <name>W4KAZ2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_314966</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545198.1">
        <property type="nucleotide sequence ID" value="XM_009546903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAZ2"/>
    <dbReference type="FunCoup" id="W4KAZ2">
        <property type="interactions" value="548"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KAZ2"/>
    <dbReference type="GeneID" id="20670180"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_314966"/>
    <dbReference type="eggNOG" id="KOG4524">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004955_0_0_1"/>
    <dbReference type="InParanoid" id="W4KAZ2"/>
    <dbReference type="OrthoDB" id="49511at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052587">
        <property type="entry name" value="TELO2-interacting_protein_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057567">
        <property type="entry name" value="TPR_TTI1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057566">
        <property type="entry name" value="TPR_TTI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049362">
        <property type="entry name" value="TTI1_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460">
        <property type="entry name" value="TEL2 INTERACTING PROTEIN 1 TTI1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460:SF3">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24181">
        <property type="entry name" value="TPR_TTI1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24173">
        <property type="entry name" value="TPR_TTI1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21547">
        <property type="entry name" value="TTI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TTI1 N-terminal TPR" evidence="2">
        <location>
            <begin position="24"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="TTI1 C-terminal TPR" evidence="3">
        <location>
            <begin position="818"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="868"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="886"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW82889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1145" mass="125828" checksum="1970D414E70E84E3" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBG6</accession>
    <name>W4KBG6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_68322</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544707.1">
        <property type="nucleotide sequence ID" value="XM_009546412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBG6"/>
    <dbReference type="STRING" id="747525.W4KBG6"/>
    <dbReference type="GeneID" id="20678853"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_68322"/>
    <dbReference type="eggNOG" id="ENOG502QR4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_2_3_1"/>
    <dbReference type="InParanoid" id="W4KBG6"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF2">
        <property type="entry name" value="BETA-GLUCOSIDASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013288775" description="beta-glucosidase" evidence="11">
        <location>
            <begin position="16"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="12">
        <location>
            <begin position="715"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW82695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="799" mass="83834" checksum="69F7CB7C55C13794" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4KD78</accession>
    <name>W4KD78_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_439593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545326.1">
        <property type="nucleotide sequence ID" value="XM_009547031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KD78"/>
    <dbReference type="STRING" id="747525.W4KD78"/>
    <dbReference type="GeneID" id="20675166"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_439593"/>
    <dbReference type="eggNOG" id="ENOG502S9QR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063099_1_0_1"/>
    <dbReference type="InParanoid" id="W4KD78"/>
    <dbReference type="OrthoDB" id="3362246at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487:SF2">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844415" description="Secreted protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW83041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="21838" checksum="8C5EA98AC35B196D" modified="2014-03-19" version="1">MKSAFTSLVAVALFVVAAVAQSTLTVNTPANVVVCQPLQITWSGGTAPYFLSVLPGGDPSGSALEDFGQQTGTSFTWTKVNQPVGTSLGLTLRDSNGLTAQSAPFTVNSGSDTSCLTASASASGTASSASASGTSSSSAAVTSSAVGSSSVSSAVATTSTTPATTAASSASAASSAASTTRPASSATSSSASRSSSAASSAASTSANAVPTLAARYGAAGIIGAVVAAVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDD7</accession>
    <name>W4KDD7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycoside hydrolase family 79 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_163513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545390.1">
        <property type="nucleotide sequence ID" value="XM_009547095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDD7"/>
    <dbReference type="GeneID" id="20667849"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_163513"/>
    <dbReference type="HOGENOM" id="CLU_1713512_0_0_1"/>
    <dbReference type="InParanoid" id="W4KDD7"/>
    <dbReference type="OrthoDB" id="2831684at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW83106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="153" mass="16716" checksum="CD661EF8EACC3212" modified="2014-03-19" version="1">MVVLVVRPCDQADRRPRGYKYSATNSDVHCLQLCLRMLLKAHLLCACSVWEAVFASQLVTLPKISSRPSNASQILDRSLASLSIEFAFLDVFGGNNSNPNILTRELMQRLVERTGVGPDIRPGGITIDSSVFSEHGPSLLLAENPSGGIYRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDJ5</accession>
    <name>W4KDJ5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Telomerase reverse transcriptase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Telomerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_450817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the reverse transcriptase family. Telomerase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545438.1">
        <property type="nucleotide sequence ID" value="XM_009547143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDJ5"/>
    <dbReference type="STRING" id="747525.W4KDJ5"/>
    <dbReference type="GeneID" id="20676081"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_450817"/>
    <dbReference type="eggNOG" id="KOG1005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_611188_0_0_1"/>
    <dbReference type="InParanoid" id="W4KDJ5"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000333">
        <property type="term" value="C:telomerase catalytic core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003720">
        <property type="term" value="F:telomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003545">
        <property type="entry name" value="Telomerase_RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066:SF0">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0158">Chromosome</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0779">Telomere</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW83156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="448" mass="50703" checksum="5D0C58E6F05B6402" modified="2014-03-19" version="1">MFHLLTETCLFAPLPNDCLCQMTGEPIVYMKVPLFKRVLEPAAAVAVDERIRAKRKAQGPPEGGEARKRMRLADGSASSLRTSSANAFRTAADVSIARSRLFYARPSFVPHKHHIIVGLPSKHILNTLNPSYHKKNNAHPYEPPNQRKQMQDARHLSKYVFPRMYALPNAFTLPASSNYKTYVVPNFEDREAEIKLQGKCKTPKRLASVIGYLEKLIYRHGKCRYKSLRDHTCPSKLRDEQQKMIDSSVILELVSEQSIRLKSQQSLTTANRSIDSLGCTIVPGGTTQARVDVKSKPRFTEFTCSHVEIFRYAVLVTKAVIPKAFWGSDKNFKLVMNCEPRLTYSKTEAEEILRQRKLGFSFVRLLPKDTGVRPIVNLRRKRLQQKGSLASNPQSINDILQAAFQILTYEKNAQPHLLGSSVFGPNEIYGQLKAYKSRLAFDNPTGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDR3</accession>
    <name>W4KDR3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RRN7-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_314041</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRN7/TAF1B family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543714.1">
        <property type="nucleotide sequence ID" value="XM_009545419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDR3"/>
    <dbReference type="FunCoup" id="W4KDR3">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KDR3"/>
    <dbReference type="GeneID" id="20670084"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_314041"/>
    <dbReference type="eggNOG" id="ENOG502S2NQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029055_0_0_1"/>
    <dbReference type="InParanoid" id="W4KDR3"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048538">
        <property type="entry name" value="Rrn7_cyclin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048540">
        <property type="entry name" value="Rrn7_cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033599">
        <property type="entry name" value="TAF1B/Rrn7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576:SF2">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20645">
        <property type="entry name" value="Rrn7_cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20644">
        <property type="entry name" value="Rrn7_cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Rrn7/TAF1B N-terminal cyclin" evidence="11">
        <location>
            <begin position="203"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Rrn7/TAF1B C-terminal cyclin" evidence="12">
        <location>
            <begin position="314"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="140"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="201"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW83992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="608" mass="67481" checksum="AC0E749D386A5B99" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEE7</accession>
    <name>W4KEE7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_155130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543456.1">
        <property type="nucleotide sequence ID" value="XM_009545161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEE7"/>
    <dbReference type="STRING" id="747525.W4KEE7"/>
    <dbReference type="GeneID" id="20667552"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_155130"/>
    <dbReference type="eggNOG" id="ENOG502S0PE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057546_1_3_1"/>
    <dbReference type="InParanoid" id="W4KEE7"/>
    <dbReference type="OrthoDB" id="449382at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF1">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="1">
        <location>
            <begin position="125"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="277" mass="31217" checksum="9A0448BA4AE2B0E0" modified="2014-03-19" version="1">MDALDPDYVARTLSNPPFVSISGVYNVRCLGNYRTQHSNEVTRANFMFRAGEVSGITDDGKHRMHDLGITTVYDLRSDTEILKYNTPTPCIDGVEIIHVPVFEKKDYSPEMMARRFQLYASGKTEAFMQLYSEILDSGGPAFGTILRHVRDRPQDSFVFHCTAGKDRTGVVAAILLLLAGVDEEIIATDYSLTRVGREPAREMVMARLEKEPIFAENQEAALNMFSSRHETMIAFLRMFKERYGGAEEYARTYCGLSDDDIGLIRRHIVAPIDRAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEI6</accession>
    <name>W4KEI6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_426715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545722.1">
        <property type="nucleotide sequence ID" value="XM_009547427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEI6"/>
    <dbReference type="GeneID" id="20674140"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_426715"/>
    <dbReference type="HOGENOM" id="CLU_1713513_0_0_1"/>
    <dbReference type="InParanoid" id="W4KEI6"/>
    <dbReference type="OrthoDB" id="5584477at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="153" mass="17509" checksum="C02EE857992DAEC9" modified="2014-03-19" version="1">MADEHELSFLIDWEPATIFGQSRHDGSCHIGTMPFMALALLNEEYWEGKMKRQYHHDLEGFLLLKLGFLNDIEDGPALLRMKATPSHEMGWILFCDILPSIHESWSPQSGSTGVEVSEDAYAKVSSKETYLDFWKRVKTLANLPRTKELIPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEW1</accession>
    <name>W4KEW1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_312598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543383.1">
        <property type="nucleotide sequence ID" value="XM_009545088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEW1"/>
    <dbReference type="GeneID" id="20669970"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_312598"/>
    <dbReference type="HOGENOM" id="CLU_189570_0_0_1"/>
    <dbReference type="InParanoid" id="W4KEW1"/>
    <dbReference type="OrthoDB" id="5370359at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW83606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="89" mass="10048" checksum="ECB235326753710D" modified="2014-03-19" version="1" fragment="single">KPSCKIGTARFVYDGVCADHVVFGALMGLDSPPAWKMKKLPKDDFEDLFGAVVGSVRYDDLYITSQINIRWTAETGGVQNQWFIWKFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFG9</accession>
    <name>W4KFG9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_450031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544243.1">
        <property type="nucleotide sequence ID" value="XM_009545948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFG9"/>
    <dbReference type="STRING" id="747525.W4KFG9"/>
    <dbReference type="GeneID" id="20676001"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_450031"/>
    <dbReference type="eggNOG" id="ENOG502S8U4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017235_0_0_1"/>
    <dbReference type="InParanoid" id="W4KFG9"/>
    <dbReference type="OrthoDB" id="74813at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="502" mass="54966" checksum="DA3A309F7150B9A1" modified="2014-03-19" version="1">MSVSEPMRRIRLTSAPPLPPLKAWFSISIIAVDAPVSDLKSHLCSTLQILRDAELQASDIELLFDDFELLSESRVDVLRDGDLVCIHQKPKNAKRKAPPSQSPSRKKRRLPSPVPSPPRPVPSLKKRSPPSHSTSSEDSSSDDSSSDDSSDTSSTSSDSDSGSDASSSPSVVKSSKPPPRGQKSDQSIAHVPPGYGKPQTRSRNIRRRKKRQYEREADDTQTPASIIPIASPNAVPLGSKPSLSTPPLPAESLSRPEPVAMMSLSNKNKRRGFKRSMAESRPNRIVFDTEDSTPIAASPVPGLSRPASRSHLPRLIPPSEKQDLGLLPPNMFVTSVDVEAGLWPRREHANDDAGQNGHADRPRRAKRRNIAPEKEYDEGNQVSQDTALPYDDESAAAMGAAEDIDWDGVERRWATLTKVVRGANMSPGYLVGWKELGIHPVTLTPEMLLSIARVVRCDESEVAVQQVRRPGMGAVSFGGHVEEEEEIEVYGWNDVSEWRAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFH2</accession>
    <name>W4KFH2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_314737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543524.1">
        <property type="nucleotide sequence ID" value="XM_009545229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFH2"/>
    <dbReference type="STRING" id="747525.W4KFH2"/>
    <dbReference type="GeneID" id="20670154"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_314737"/>
    <dbReference type="eggNOG" id="KOG2940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046586_0_3_1"/>
    <dbReference type="InParanoid" id="W4KFH2"/>
    <dbReference type="OrthoDB" id="16816at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050602">
        <property type="entry name" value="Malonyl-ACP_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090:SF1">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW83776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="35970" checksum="18718B2BFA2655B2" modified="2014-03-19" version="1">MHHAQRVRLLASVASSSPVNPNTVGPFQVFDRHAKRLQKDRAAAHEDGQRSRMVDYVRDEVADRMIERFLDIKRKFSSILDLGSGPGHFSRLLEPEQTDKITMLDLSPRILHRDPDSEFEVPVERLEVDEEQLLASIPRNSQDAIVSCLSLHWVNDLPGVLVQIREALKPDGVFMGALFGGDTLFELRTALQLAEVDREGGVSPHVSPMANPRDMSNLMGRAGFTLLTVDVDEVRAGYPSMWELMDDLRDMGESNAVLGRRHIIRRDTLAAASAIYKELHGEPDGTIPATFQVIYVIGWKPAPTQPKPLERGTGKTNLQDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFP7</accession>
    <name>W4KFP7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_450090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544306.1">
        <property type="nucleotide sequence ID" value="XM_009546011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFP7"/>
    <dbReference type="GeneID" id="20676004"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_450090"/>
    <dbReference type="HOGENOM" id="CLU_2250492_0_0_1"/>
    <dbReference type="InParanoid" id="W4KFP7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="104" mass="11531" checksum="19C70ECE22C9230C" modified="2014-03-19" version="1">MGDENRRQKLTELMARRESEARANARISPEIAASMQSAREMERRLKRLMLPLRRAIAESKALSAHIKVERDKLRATMARLGLESGYGEERRDGGAGGVAATPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGE3</accession>
    <name>W4KGE3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_312374</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544554.1">
        <property type="nucleotide sequence ID" value="XM_009546259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGE3"/>
    <dbReference type="STRING" id="747525.W4KGE3"/>
    <dbReference type="GeneID" id="20669949"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_312374"/>
    <dbReference type="HOGENOM" id="CLU_101063_0_0_1"/>
    <dbReference type="InParanoid" id="W4KGE3"/>
    <dbReference type="OrthoDB" id="3260945at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030894">
        <property type="term" value="C:replisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="35"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW84933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="240" mass="27103" checksum="62585F06005699B1" modified="2014-03-19" version="1">MNGWTSPEGILYIKETLCTLLPWPNSPHNWQVNSTANILEENNQLVIVACGEGKTAVAYLHHILISHLSKKPLRSLPPFVRSIRSTTVVLMITPLIDVGLCQVEEMSRMGVRVVLLDKETVREAHQKGKNLLKEVEQGKWSVIIVSPERLNSPEFERIVQNEWFRKLLALYVINEAHVVLPWAADFCEAYGQINHFIVRIPVGIPVLAMSRTLGSEAKTSLTKFLGFCDGTYQTIQRSCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KH71</accession>
    <name>W4KH71_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_416082</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544064.1">
        <property type="nucleotide sequence ID" value="XM_009545769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KH71"/>
    <dbReference type="GeneID" id="20673287"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_416082"/>
    <dbReference type="HOGENOM" id="CLU_1034614_0_0_1"/>
    <dbReference type="InParanoid" id="W4KH71"/>
    <dbReference type="OrthoDB" id="2260578at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW84386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="269" mass="29244" checksum="CD3CF0DB756620CD" modified="2014-03-19" version="1">MDTSIQSGAHPLKSACPFSNIAAVNGTVCRDEPGNTNIRPKRAAIACTECRRRQVRCASSSNPSRCRRCEKMDLTCTFVRNSAYRTTAIPQADALGERWSSLSQQQGQTPSSYVLPRNDDLITGEGSVLPGYATEAVYPAPLFSSTGVERTHFQVDWYGGVPSSQSYNLAPTHNDFHYEPPTHHNPSALFTNGQSSLIEPAYPLYYPQTCQPASYGSAQPTHTSPWVITAELEGSLSRSAYDEWPSGASTAIVAPDNDYNGSYGGNHQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4KH80</accession>
    <name>W4KH80_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_414303</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542086.1">
        <property type="nucleotide sequence ID" value="XM_009543791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KH80"/>
    <dbReference type="STRING" id="747525.W4KH80"/>
    <dbReference type="GeneID" id="20673165"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_414303"/>
    <dbReference type="eggNOG" id="ENOG502SM5A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006344_1_0_1"/>
    <dbReference type="InParanoid" id="W4KH80"/>
    <dbReference type="OrthoDB" id="3199698at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="655"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="665"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW85213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="848" mass="95843" checksum="B73CCAA52B888E87" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIE9</accession>
    <name>W4KIE9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_310432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542475.1">
        <property type="nucleotide sequence ID" value="XM_009544180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIE9"/>
    <dbReference type="STRING" id="747525.W4KIE9"/>
    <dbReference type="GeneID" id="20669779"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_310432"/>
    <dbReference type="eggNOG" id="KOG1183">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007914_0_1_1"/>
    <dbReference type="InParanoid" id="W4KIE9"/>
    <dbReference type="OrthoDB" id="70250at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="501" mass="57480" checksum="700B311E41FE8809" modified="2014-03-19" version="1">MSSNRYLLYPVEDVDKDGWLYGWSDRQCTCIAGILQCVSRNAAQQCLDILLHQGAYPNAHCALPKVLGHSSLWNERPVSRLHSMSDNAPFSSQSPTTFLYHRSAFGNMRLQLSDTISGAPRSDAQYFSFDESLQLGHLGLNQSITNQLNFAQQLAVNILASGSLLSQIQMVIGKSVPWRSFGCHQSIRLFYCALLFLEEFMKMQWLINTSNLVSQGRMRIRSIIVLLQSSRISNQLNNTIWLTLNDLILGVAIGSFVCENHAAISSKFDKSMNYVFIELVTECLIWLNNWPAGLKLNTELSSFCCHMFLGIIGIWTYFYQSLSLHFPMIVYFIGIIGYCGLTFLLSTFLDLLRLLTLHISLGFIIWNRLIKFQLSFLQSLGNLFHGKQLNVLHNRIEPWHYEVDQLILGTILVTLFTFSLPTFLSYFMLFAIFKHLVIIIETLIQQLIELMNKFPLFPLILKIKHPARLTGFFYFLLQNGIQNLKGQYMSFLSIFQYFDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJ25</accession>
    <name>W4KJ25_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL49</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_28279</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL49 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541727.1">
        <property type="nucleotide sequence ID" value="XM_009543432.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJ25"/>
    <dbReference type="STRING" id="747525.W4KJ25"/>
    <dbReference type="GeneID" id="20669285"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_28279"/>
    <dbReference type="eggNOG" id="KOG4034">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085757_4_0_1"/>
    <dbReference type="InParanoid" id="W4KJ25"/>
    <dbReference type="OrthoDB" id="19439at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007740">
        <property type="entry name" value="Ribosomal_mL49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05046">
        <property type="entry name" value="Img2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW85719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="87" mass="9838" checksum="7D74803971DA3A02" modified="2014-03-19" version="1" fragment="single">YYVPRNSRGSLPVYTDIRNGGSRFLISVRNVQGNVDALVHDLTQSLFPQGSPEAERIKVYALRSKHVVLSGGRWKHDIVEWLKGKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJ33</accession>
    <name>W4KJ33_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTP-binding protein ypt1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_407640</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Preautophagosomal structure membrane</location>
            <topology evidence="8">Lipid-anchor</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542554.1">
        <property type="nucleotide sequence ID" value="XM_009544259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJ33"/>
    <dbReference type="FunCoup" id="W4KJ33">
        <property type="interactions" value="696"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KJ33"/>
    <dbReference type="GeneID" id="20672617"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_407640"/>
    <dbReference type="eggNOG" id="KOG0084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_10_1_1"/>
    <dbReference type="InParanoid" id="W4KJ33"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000069">
        <property type="entry name" value="Ras GTP-binding protein YPT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="174"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW85724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="204" mass="22599" checksum="3E50921AE5C44157" modified="2014-03-19" version="1">MHTSEYDFLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELEGKTVKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDNDTFTNVKQWLQEIDRYASEGVNKLLVGNKSDLTSKKVVEYSVAKEFADQLTIPFLETSAKNATNVEQAFLTMAKQIKDRMGSTSTPSGAGKSSTITPGQTVQQQQSGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJ95</accession>
    <name>W4KJ95_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">eRF1/Pelota-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_379314</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542249.1">
        <property type="nucleotide sequence ID" value="XM_009543954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJ95"/>
    <dbReference type="FunCoup" id="W4KJ95">
        <property type="interactions" value="803"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KJ95"/>
    <dbReference type="GeneID" id="20671964"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_379314"/>
    <dbReference type="eggNOG" id="KOG0688">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035759_2_1_1"/>
    <dbReference type="InParanoid" id="W4KJ95"/>
    <dbReference type="OrthoDB" id="10254527at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.960.10:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000006">
        <property type="entry name" value="Peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03676">
        <property type="entry name" value="aRF1_eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="5">
        <location>
            <begin position="3"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW85385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="437" mass="49207" checksum="50CAE812DCB508A0" modified="2014-03-19" version="1">MSQDQAEQNIQMWKVKKLIKSLDAARGAGTSMISLIIPPKDQISRASAMLTQEYGTASNIKSRVNRLSVLAAITSTQQRLKLYNRVPPNGLVLFVGTILTDEGKEKKVSFDFEPHKPINTSLYLCDNKFHTEALSELLESDSRFGFIVMDGNGTLFGTLAGNTREVIHKFTVDLPKKHGRGGQSALRFSRLRDEKRHNYIRKVAELAVQHYITNDKVNVTGLVLAGSADFKTELGQSDMFDLRLAAKIIKVVDVSYGGENGFNQAIELAAESLANVKFVQEKKLIQRYFDEISQDSGKYCFGIDDTLKALELGAVETLIVWENLDITRYVLRNAANEENIVHAKKEQEKDREKFLDKSTGLEMEQAIEPQPLLEWFAEKYKEFGANLEFVTDRSQEGAQFVKGFGGIGGLLRYKVDFTNLTSIDEEEDEFYSDDEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJM4</accession>
    <name>W4KJM4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HETIRDRAFT_448422</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542132.1">
        <property type="nucleotide sequence ID" value="XM_009543837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJM4"/>
    <dbReference type="STRING" id="747525.W4KJM4"/>
    <dbReference type="GeneID" id="20675856"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_448422"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001650_15_5_1"/>
    <dbReference type="InParanoid" id="W4KJM4"/>
    <dbReference type="OrthoDB" id="2776596at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0229">DNA integration</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="14">
        <location>
            <begin position="111"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="13">
        <location>
            <begin position="353"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="184"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="241"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETW85261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="443" mass="50482" checksum="2A99F8110D0EBD88" modified="2014-03-19" version="1">MFGKSRCLRYLSSAVWYLPKASRIPPSDPSAGACSSPLQNGVAECLNKTIVERGRAMMHETGLPRFLWPEVVSTSIYLKNLGPTVALEGKTPHEVWTGQKPNVKHLHAFGCKALVKIPDEKCCKWDVKSTECILIGYYSDAAYRCYKLRTHRIVKLRDIVFLEDDLPLAPRKLPVAERGENDFHVAQEPPTDTPPPPKVSPDNPTMKSPLAQQPPPLQAPPKPPEPKTSTQTPAPTQFTLRRSERAREPLSLRKATDLQEATERARRDANREARERQKDQEKKQDEAARDEREEAEAEEHKAAVEHSLFTAAVEAALLMAGEEPRSYQEAIRSTERDDWQRAMEEEYDALLKNKTWELVKPAKGRKPIGSKWTYKAKQDGRFKAQLVAQGFMQRPGVDFHDTHFPENWLLKQIDVKSTYLNGKLDEEIFMRQPEGFQVLRKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJW1</accession>
    <name>W4KJW1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_311624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542455.1">
        <property type="nucleotide sequence ID" value="XM_009544160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJW1"/>
    <dbReference type="GeneID" id="20669886"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_311624"/>
    <dbReference type="HOGENOM" id="CLU_196207_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJW1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844485" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="7433" checksum="F9809A15CA94CAFC" modified="2014-03-19" version="1">MSYLPFSFLIVLCNLNTHGLRVILSSDSYPLDHSPVVIELLFGTLSVPVASLSLRSTINCQGALVVSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJX2</accession>
    <name>W4KJX2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_432303</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542465.1">
        <property type="nucleotide sequence ID" value="XM_009544170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJX2"/>
    <dbReference type="STRING" id="747525.W4KJX2"/>
    <dbReference type="GeneID" id="20674604"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_432303"/>
    <dbReference type="eggNOG" id="ENOG502S10Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026509_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJX2"/>
    <dbReference type="OrthoDB" id="7700931at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF122">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845438" description="FAS1 domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="77"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW85625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="671" mass="74864" checksum="D92FCA99313A771F" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKM3</accession>
    <name>W4KKM3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar protein sorting 55</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_380051</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542698.1">
        <property type="nucleotide sequence ID" value="XM_009544403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKM3"/>
    <dbReference type="FunCoup" id="W4KKM3">
        <property type="interactions" value="312"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KKM3"/>
    <dbReference type="GeneID" id="20672001"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_380051"/>
    <dbReference type="eggNOG" id="KOG2174">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134810_0_1_1"/>
    <dbReference type="InParanoid" id="W4KKM3"/>
    <dbReference type="OrthoDB" id="14246at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034424">
        <property type="term" value="C:Vps55/Vps68 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050">
        <property type="entry name" value="LEPTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050:SF0">
        <property type="entry name" value="RH04491P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04133">
        <property type="entry name" value="Vps55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW85890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="13840" checksum="FBC9BCEF8C8DE94A" modified="2014-03-19" version="1">MAAGIKTVILLSFILAVGFLMIILSCALWSNWLPLLVALMFVMAPLPNALFSHCGGDDFSTDAYESSGPVDLGRFITAMIVVTGFAFPLVLAHSEIIKPGASAMSIVGGGLIYGTIMAYAAAFKQDDSEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKP1</accession>
    <name>W4KKP1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_100125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543129.1">
        <property type="nucleotide sequence ID" value="XM_009544834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKP1"/>
    <dbReference type="GeneID" id="20665667"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_100125"/>
    <dbReference type="HOGENOM" id="CLU_1740742_0_0_1"/>
    <dbReference type="InParanoid" id="W4KKP1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="150" mass="16720" checksum="F60CC19DA99091C7" modified="2014-03-19" version="1">MPVGHALPLTFYAKLQKILRRNANSTREILRSRPWRHFPPNAQVQTDLNLGTELDTIDLDFDVDDECDDCGLVNLSSSTPLKIMTIPDTAPAQRHLRNIIQYPAGDGREEGSSTQIQAHSAQVSLSCDAMDSPPLWEEFEQPYSGSPEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KL18</accession>
    <name>W4KL18_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_432387</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542584.1">
        <property type="nucleotide sequence ID" value="XM_009544289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KL18"/>
    <dbReference type="STRING" id="747525.W4KL18"/>
    <dbReference type="GeneID" id="20674608"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_432387"/>
    <dbReference type="eggNOG" id="KOG0211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006095_0_0_1"/>
    <dbReference type="InParanoid" id="W4KL18"/>
    <dbReference type="OrthoDB" id="340346at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="472"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="626"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="218"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="572"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="916"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="580"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW85756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="941" mass="101571" checksum="2FAD55D133E792DA" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4KL45</accession>
    <name>W4KL45_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Esterase/lipase/thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_60559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541850.1">
        <property type="nucleotide sequence ID" value="XM_009543555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KL45"/>
    <dbReference type="STRING" id="747525.W4KL45"/>
    <dbReference type="GeneID" id="20678519"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_60559"/>
    <dbReference type="eggNOG" id="ENOG502S28Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016852_1_1_1"/>
    <dbReference type="InParanoid" id="W4KL45"/>
    <dbReference type="OrthoDB" id="6495301at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="44"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW85771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="294" mass="32833" checksum="93A2C1CEAEB56210" modified="2014-03-19" version="1">MELFLDLLYVPQTGKSDSRDRPHEFDLYVPHVSLDKEHKPALICFIHGGAWRSEDKADHSTLAQSLATFTGCPVAVPNYRLTPREPTADSALLHPAHAEDILRFLTFAHEWDGSPISAGPLYDPELIFLMGHSCGAHMLASIILDSAPVTPSLAPRPALLRAVQGVILSEGIYDIDLLLASFPDYRTWFIASAFGEHHSYAAYATTKFPVRKDGGHIRWLVVHSKGDTLVDQRQSEVMYEHLQRIHEKQDGGSSNRRVFKDWEALNEEHNDILRGDIFVRVVGDFVSGKQGSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KL65</accession>
    <name>W4KL65_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_307631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540465.1">
        <property type="nucleotide sequence ID" value="XM_009542170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KL65"/>
    <dbReference type="GeneID" id="20669512"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_307631"/>
    <dbReference type="HOGENOM" id="CLU_2292049_0_0_1"/>
    <dbReference type="InParanoid" id="W4KL65"/>
    <dbReference type="OrthoDB" id="3133596at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="101" mass="11610" checksum="BCB7968E89ECAD0C" modified="2014-03-19" version="1">MFIWGLVISAYLFTQQDSERRVRDSGQAQSISRTDTPVIPSMRDHNRKSKRLVASTQVKRCLLTQELSSEASVSSCYLLNQRLWNSELVRSTEHRFGDCSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLU1</accession>
    <name>W4KLU1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_438709</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543078.1">
        <property type="nucleotide sequence ID" value="XM_009544783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLU1"/>
    <dbReference type="FunCoup" id="W4KLU1">
        <property type="interactions" value="433"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KLU1"/>
    <dbReference type="GeneID" id="20675070"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_438709"/>
    <dbReference type="eggNOG" id="KOG1596">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059055_2_0_1"/>
    <dbReference type="InParanoid" id="W4KLU1"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020813">
        <property type="entry name" value="Fibrillarin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00566">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW86330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="216" mass="23613" checksum="4606B22A7E6D8E17" modified="2014-03-19" version="1">MLVTKNIAPGESVYGEKRISIDGGVDGTKVEYRVWNPFRSKLAAGVLGGMDHIYIAPGKKVLYLGAASGTSVSHVADIVGPEGVVYAVEFSPRSGRDLINMAKKRTNVIPIVEDARFPNKYRMLISSVDVIFADVAQPDQARIVAHNAHSFLKQGGHVVISIKANCIDSTAPAEVVFQNEVAALRNEKFKPLEQITLEPYERDHAMVTAVYLRHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLX9</accession>
    <name>W4KLX9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_377301</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540719.1">
        <property type="nucleotide sequence ID" value="XM_009542424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLX9"/>
    <dbReference type="STRING" id="747525.W4KLX9"/>
    <dbReference type="GeneID" id="20671871"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_377301"/>
    <dbReference type="eggNOG" id="KOG1630">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046868_1_0_1"/>
    <dbReference type="InParanoid" id="W4KLX9"/>
    <dbReference type="OrthoDB" id="1277691at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF112">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW86724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="337" mass="36277" checksum="F8CA4126FE10338E" modified="2014-03-19" version="1">MLRVGVFTSTRSFLRPTVNQVHAGSHFPSFRTLSTRTSRSSILDALKMRPSGSSVFSSSKPFARGIMNDAVVVRPTKEETWKKYAITAATVAGTIVGVEVFLNRDTRDSLSAAEQSYLHDSFKYTGGGLVLTALAARSMFKAGLPLRIMTANPWLVLGVSLVGSIGSMMGVFYTPPEKTVQKHAFWLAFNACQAATLSPLFFLSPAILSRAALYTCGVVGSLSYVGATATNDKYLYMGGPLLAGVTVVALSSLAPMALPLGIRGLAIAESISLYGGLAVFSGFVLFDTQKILQHARMAERGAMTPDPMRESVSLELDMINIFIRIVQILAMQKNSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4KME1</accession>
    <name>W4KME1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_468790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540962.1">
        <property type="nucleotide sequence ID" value="XM_009542667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KME1"/>
    <dbReference type="STRING" id="747525.W4KME1"/>
    <dbReference type="GeneID" id="20677252"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_468790"/>
    <dbReference type="eggNOG" id="ENOG502SJ3W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020637_0_0_1"/>
    <dbReference type="InParanoid" id="W4KME1"/>
    <dbReference type="OrthoDB" id="3226575at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="60"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="540" mass="62386" checksum="5C5803377E517AE0" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMR7</accession>
    <name>W4KMR7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_99509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541053.1">
        <property type="nucleotide sequence ID" value="XM_009542758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMR7"/>
    <dbReference type="GeneID" id="20678907"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_99509"/>
    <dbReference type="HOGENOM" id="CLU_2855879_0_0_1"/>
    <dbReference type="InParanoid" id="W4KMR7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="65" mass="7093" checksum="8556EACEFE92791F" modified="2014-03-19" version="1" fragment="single">GGGRPARARSITDDPWDATSDRDDDDDDDDGDGDNDDDGDKGRGGRTWPDPRRGPRHDVPHPDPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KN77</accession>
    <name>W4KN77_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_306002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540525.1">
        <property type="nucleotide sequence ID" value="XM_009542230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KN77"/>
    <dbReference type="GeneID" id="20669365"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_306002"/>
    <dbReference type="HOGENOM" id="CLU_001650_16_0_1"/>
    <dbReference type="InParanoid" id="W4KN77"/>
    <dbReference type="OrthoDB" id="3344688at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="57" mass="6481" checksum="9EFC3E2D21047E74" modified="2014-03-19" version="1" fragment="single">YHAHTKHIGIQDHFLQEKVVSGDLRLEYMPMGDQVADVLTKGLTMEKHELFSKGMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNY1</accession>
    <name>W4KNY1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH-quinone oxidoreductase subunit D domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_456657</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540740.1">
        <property type="nucleotide sequence ID" value="XM_009542445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNY1"/>
    <dbReference type="STRING" id="747525.W4KNY1"/>
    <dbReference type="GeneID" id="20676766"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_456657"/>
    <dbReference type="eggNOG" id="KOG2870">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_1_1_1"/>
    <dbReference type="InParanoid" id="W4KNY1"/>
    <dbReference type="OrthoDB" id="1009at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.645.10:FF:000005">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004739">
        <property type="entry name" value="PRK06075.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="6">
        <location>
            <begin position="190"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW86751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="460" mass="52267" checksum="E0390CE56DB4408B" modified="2014-03-19" version="1">MASTLLRRQLPRISHLAPRRCISTSSSLYQQTESRGAYTPEGKHVFDTHTVEDLHGMAAKDILAETGSRKESQMRHFTVNFGPQHPAAHGVLRLILELNGEEILRADPHIGLLHRGTEKLIEYKTYMQALPYFDRLDYVSMMTNELCYSLAVEKLLNIEVPERAKWVRTLFGEITRILNHLMAVLTHAMDVGALTPFLWGFEEREKLMEFYERVSGARLHAAYVRPGGVAFDLPHGLLNDIFQWATQFSSRVDEIEEVITGNRIWKQRTIGVGKVTAQEALDYSFSGVMLRGSGVKWDLRKVAPYDKYDEVEFDIPVGKNGDCYDRYLCRVQEMRESLRIIDQCLNKITTGPVKVDDHKLVPPPRASMKESMESLIHHFKIFSEGYSVPPGETYSAIEAPKGEMGVYLVSDGTNRPYRCKIRAPGFAHLAGADFMMRRHFIADVVAIIGTMDLVFGEVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4KP18</accession>
    <name>W4KP18_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_307211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541473.1">
        <property type="nucleotide sequence ID" value="XM_009543178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KP18"/>
    <dbReference type="STRING" id="747525.W4KP18"/>
    <dbReference type="GeneID" id="20669468"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_307211"/>
    <dbReference type="eggNOG" id="KOG3069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034764_0_0_1"/>
    <dbReference type="InParanoid" id="W4KP18"/>
    <dbReference type="OrthoDB" id="70823at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF44">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="46"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW87588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="438" mass="47460" checksum="33C1BF218C349D9D" modified="2014-03-19" version="1">MSTTDSIPPHASPASDPKSITGLLSRALRRIRSTPPRIIASPATQPRRAAVALILRVVPPPNVPLPPSPPPAPPSLTDFFDLDWVKHPAARPEILFLRRAKADASEAHANTRDAHVAFPGGRMEEGDEGGLYTAMRQTWEEIGLDLAEADYTCIGQLDDREITTSLGKRLLMILSPYVFLQLTPTDPSTDPTPETSLHWIPLTALFPSPTSVIGPCPGPLWSTVTVDAASRLAPRHSTALRLLMRALVGSMQFPALVLAPPAAPIDPDASPEKEPLPRGSLEALKLWGLSLGMTLDLLAYMAPAPGAPLTPWDADALMGVSGLPLGADEDIDYDSGRGGRRGRGRINAPPSLTAVFPRFSYPDVNFWIWVFGKRYREVIRGWETSVRAGGTNDRRINWTGAALTTFYAAVRKALIVVLVLRAIGVLVSVTVGLWWAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPE8</accession>
    <name>W4KPE8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_447815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541183.1">
        <property type="nucleotide sequence ID" value="XM_009542888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPE8"/>
    <dbReference type="STRING" id="747525.W4KPE8"/>
    <dbReference type="GeneID" id="20675806"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_447815"/>
    <dbReference type="eggNOG" id="ENOG502QQFN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_1_0_1"/>
    <dbReference type="InParanoid" id="W4KPE8"/>
    <dbReference type="OrthoDB" id="58297at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562:SF2">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="154"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="245" mass="27474" checksum="9610800F2E835506" modified="2014-03-19" version="1">MLINTTYKDVPTQLDPNGRPIRFLVITPNVPNYPNAKFPGVVVFSEIYQVTGPVERFAGQIASNGYVVVCPSIYHEFQGPEAIPYDVEGTDRGNRFKIEKEVAAYDEAFRASFHPRVLASFCFFATDIHSATLGKGKSDDSLAKVRAGGLNGDKELVMVFGKQDTHVPRAGRDLIRQTLEDANVTVTFLEVQAQHAFIRDESSKGRWDAALTRSMFTSLMELFERRVGRDLGERVEDNREIEHVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPG6</accession>
    <name>W4KPG6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_306671</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541192.1">
        <property type="nucleotide sequence ID" value="XM_009542897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPG6"/>
    <dbReference type="FunCoup" id="W4KPG6">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KPG6"/>
    <dbReference type="GeneID" id="20669428"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_306671"/>
    <dbReference type="eggNOG" id="KOG1764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021740_2_0_1"/>
    <dbReference type="InParanoid" id="W4KPG6"/>
    <dbReference type="OrthoDB" id="286637at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04641">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="59"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="144"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="235"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="310"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW87270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="390" mass="42822" checksum="A6F85A83F85614F9" modified="2014-03-19" version="1">MNATLAAAASPRPKRKGSVRRPRAASHLPPVQTQETHDLALQSIRAFLKGRASYDAFPVSFRLIVLDSELEVKKALQCLLTNGVVSAPLWNSERSQFAGMFTVSDIIHLIQYYYHTSSYDNAAADVETFRLESLRDIEKELGVATPPLLYEHPNSSLYDAARVLIHSHARRLPLLDYDSETGHEVIVSVLTQYRLLKFISINCTKEMQSLHLPLRKLGIGTYISKPLFSTDDGEMPPGHNRYHPIATATLSTTVFDVVHMFSERGISAVPIVDENGVVVNLYETVDVITLVKLGAYQSLDLTISEALNQRSPDFPGVVICTGADSLGTLLQLIKKRRVHRLVVVEGDKGRLLGVLTLSDVLRYVIGDVGIKESTEPAEEPPAAAAAAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPI2</accession>
    <name>W4KPI2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_145408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541197.1">
        <property type="nucleotide sequence ID" value="XM_009542902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPI2"/>
    <dbReference type="STRING" id="747525.W4KPI2"/>
    <dbReference type="GeneID" id="20667079"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_145408"/>
    <dbReference type="eggNOG" id="ENOG502SRK6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062667_0_0_1"/>
    <dbReference type="InParanoid" id="W4KPI2"/>
    <dbReference type="OrthoDB" id="3258400at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="316" mass="34755" checksum="76B2DA2365B4EBDF" modified="2014-03-19" version="1">MSPDYFPSIDSPPSHPGPAAADFAPMPYPTQTGAHQLPMDPAYAQHHPSNDPEAPMGHALSRHLWPGAELSYPLEHHPMSTADLENPEISIHSPAALFGSWPATLATSTSQAPFLHGEGPLEPDSLAMGPPAYPPPSREHLLAYGDAPRTTFPTPSELLTELASHTPTAVGAAKRESDRKVESQRKARQRIVADNVGFTPTDPDTISSHDKKRFYLECLEQYIIYLHDQLRLVGTDPAPLERVSTYRGLSSRSIRTMLVHMQSTLKSAQDETLEEEQRFLDLSEKVHQMHRIPDAGDEQSLASAPVLADPVYTNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPS3</accession>
    <name>W4KPS3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_448242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541685.1">
        <property type="nucleotide sequence ID" value="XM_009543390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPS3"/>
    <dbReference type="GeneID" id="20675837"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_448242"/>
    <dbReference type="HOGENOM" id="CLU_442151_0_0_1"/>
    <dbReference type="InParanoid" id="W4KPS3"/>
    <dbReference type="OrthoDB" id="10680772at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
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                <person name="Asiegbu F."/>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
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                <person name="Cullen D."/>
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                <person name="van Diepen L.T."/>
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                <person name="Duplessis S."/>
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                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
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                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
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                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Stahlberg J."/>
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                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
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        </location>
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        </location>
    </feature>
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        </source>
    </evidence>
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    </evidence>
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</entry>
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                <person name="Cullen D."/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
    <sequence length="407" mass="45416" checksum="0A231B31FADFE643" modified="2014-03-19" version="1">MSGQASTSTNTPSATVQPGRGKVKLPDNYTGDRIESQKFMLQCLLLFAAESNRYKTDQDKISLVLSCMRYGTAGAWAENFLLKSVGADPPTNLGTWKDFLAKFKLQFRETGKTDKARSALMAFSQGRMTVDEYSNQFILIAADADISDKEQVPYFQRGLDPRVMDKIYDKEVQPKDTIQDWINTACKIDGRLRARTAQKAILANSTSFRSDYLNRFHNQISPRYNSTNAPRRMNNQVVDMDIDATRKCNALSQKRKHDGKPPGACYHCKKTGHWNADCPSLRRGVQPIRGNSKRRMGTTGRRNHAVDLEGEDDAPAMGNQAGIYRGMETEDVHRNNQRVPQPGPSMERPHSTPSGRPQTNHGQRTMLPNGRRGDGGVSHSARIGAVLGELGEDEAREVILGHAERFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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                <person name="Fossdal C.G."/>
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                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="20669446"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_306956"/>
    <dbReference type="eggNOG" id="ENOG502SZ9Q">
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    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="104" mass="10871" checksum="71F85F690FCA439F" modified="2014-03-19" version="1">MASNISTAFGNFVGSISTIGIAFAHSVTALFMAVLAFGQSIVSSVLHLVQAVILLGLDVFKGALGFLTANFFAIALLGGGYYWWSSRKQGRTGTGGGPRIRSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMC6</accession>
    <name>W4JMC6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_456196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553119.1">
        <property type="nucleotide sequence ID" value="XM_009554824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JMC6"/>
    <dbReference type="GeneID" id="20676710"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_456196"/>
    <dbReference type="HOGENOM" id="CLU_553271_0_0_1"/>
    <dbReference type="InParanoid" id="W4JMC6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW74619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="493" mass="53955" checksum="88792A1AE02A9CD1" modified="2014-03-19" version="1">MAVAHRASSRRRPATPPDSHSTRNPLLLPYHTVRPPPPSPLSRATSPPVLASRCPTFAVAAAAAAAARVAQVGCQNTRRARTYDVCFDRQVLTARCGEGPAAHAAAAAAVSAARRDTPAMPVPAHALPHPHISTLPPALRPPSSFLHFLFFSLLPCFLSLFPPPTTASSRPMPQTRDPSPHINSTRLTSPSHAHTHTRSRVAPVRARTPAAAPVWPPWPCGGHAPWAFFVALASSCVLRPARQPAFSSRPPLPRLARSPRLFEPLRASLSLSALRVRSHKCTRASQSQSRRRCACRRALLRFTLSTGGRRIQRVPAASRARVRVCAVHCRSCGVSCHYRVVSCHYRVVSCSCRVVFMLCHAVSCRAVPYVPRLACPSYPPTAVTRQQAPYKLNTTHAETVRHTRPRAALRLVPRLLACLGFDLSSLQQSYVAYTHVHTHARTHANAHRDPKKRPPQSDLGIEDPSTNRSGLNRRSARTPHDVHLRARPPNRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMK2</accession>
    <name>W4JMK2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_423372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553194.1">
        <property type="nucleotide sequence ID" value="XM_009554899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JMK2"/>
    <dbReference type="GeneID" id="20673901"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_423372"/>
    <dbReference type="HOGENOM" id="CLU_2558563_0_0_1"/>
    <dbReference type="InParanoid" id="W4JMK2"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW74704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="82" mass="8672" checksum="88EC108E0D77A987" modified="2014-03-19" version="1">MFGWCLAQSRNCLGAIISHSPLLLNTSSSTPALEVVLVLCSALRATSSVSPGISGMICTSTTCMLVTTPENIDVYHGRLFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4JN93</accession>
    <name>W4JN93_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tf2-1-like SH3-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_17370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW75032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553034.1">
        <property type="nucleotide sequence ID" value="XM_009554739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JN93"/>
    <dbReference type="GeneID" id="20668462"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_17370"/>
    <dbReference type="HOGENOM" id="CLU_210665_0_0_1"/>
    <dbReference type="InParanoid" id="W4JN93"/>
    <dbReference type="OrthoDB" id="2630497at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tf2-1-like SH3-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="67" mass="8112" checksum="84927860358A5B77" modified="2014-03-19" version="1" fragment="single">YGFFKILAKVRSLAYKLQIPAHWKIHSIFHVTMLTKYREIEAYRINFIKPLPEVLNNKKYYKIEAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNE1</accession>
    <name>W4JNE1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_410286</name>
        <name evidence="2" type="ORF">HETIRDRAFT_412628</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547892.1">
        <property type="nucleotide sequence ID" value="XM_009549597.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009554796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNE1"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_440675"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_442632"/>
    <dbReference type="HOGENOM" id="CLU_2133824_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW74585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW81231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="113" mass="12625" checksum="DBAB3466406E8231" modified="2014-03-19" version="1">MERKKDGQGENGQRRRTLRKSRRRSFRGKGWSPAIRQGRRERGECGCAHFGADVGRVGGDFVRGGARRGRGACAQVCSQVRCAWGLRRAEGSERARCAPGLRGWRAEVAWARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNV3</accession>
    <name>W4JNV3_HETIT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_164614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552675.1">
        <property type="nucleotide sequence ID" value="XM_009554380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNV3"/>
    <dbReference type="GeneID" id="20667925"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_164614"/>
    <dbReference type="HOGENOM" id="CLU_2794257_0_0_1"/>
    <dbReference type="InParanoid" id="W4JNV3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW75237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="68" mass="7851" checksum="5BC1B7C61D9179DD" modified="2014-03-19" version="1">MADLTKVQFTAPSDVASPLHHPTHVHSVHYCASSYIRRPFKSSKVIKMIRKYRDCCENKQMQDIDLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4JP89</accession>
    <name>W4JP89_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_456262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553196.1">
        <property type="nucleotide sequence ID" value="XM_009554901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JP89"/>
    <dbReference type="GeneID" id="20676723"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_456262"/>
    <dbReference type="HOGENOM" id="CLU_120576_0_0_1"/>
    <dbReference type="InParanoid" id="W4JP89"/>
    <dbReference type="OrthoDB" id="8955945at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW74706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="130" mass="15498" checksum="D29D76F4D664C3D7" modified="2014-03-19" version="1">MDKIYDKEVQPKDTIQDWINTACEIDGQLRARTAQKAILTVMITFCRALTAVYTDTIITNIKRPHKPVEAFNQFEETRRDAWVRQGEETVQLIWKEKTTHPLWETKQEYIEEWRRRMLIAMTSGYHNLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPL9</accession>
    <name>W4JPL9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxisomal biogenesis factor Pex19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_164353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552928.1">
        <property type="nucleotide sequence ID" value="XM_009554633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPL9"/>
    <dbReference type="STRING" id="747525.W4JPL9"/>
    <dbReference type="GeneID" id="20667911"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_164353"/>
    <dbReference type="eggNOG" id="KOG3133">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043063_0_0_1"/>
    <dbReference type="InParanoid" id="W4JPL9"/>
    <dbReference type="OrthoDB" id="21292at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033328">
        <property type="term" value="F:peroxisome membrane targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.900">
        <property type="entry name" value="Pex19, mPTS binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006708">
        <property type="entry name" value="Pex19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038322">
        <property type="entry name" value="Pex19_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774:SF2">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04614">
        <property type="entry name" value="Pex19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="331" mass="35356" checksum="92D97694B00BCABC" modified="2014-03-19" version="1">MSGVNSQKARVDVDEDVDDLDDVLDQFSTEALKPTAAPPLTSKSTILPSSSAVAPAGSDDFSDDFARELARGMESLMRDMGAPLGNAGEVPGSAASVDPAEEQRREEAFRKAWEAMLIEGMDGAVPGLDDIAGVTAKSGPGASTGAEADTGKEREKATGAAEDDFQKNIRAAMQKLKESEQNLRDSQAASTNDDDLEKLLAEFGEGKTEDELSGLLDGMMSHLMSKDILYEPFKELSDKFPPYLEENKATLSEQQYRQYTAQHASIAKMIAIFEDPSYSDSDSSQNAAVVSLMTEMQSYGSPPVEIMGELPPGLDLGADGLPQLPEGCIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQ69</accession>
    <name>W4JQ69_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_332054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW75026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553477.1">
        <property type="nucleotide sequence ID" value="XM_009555182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQ69"/>
    <dbReference type="GeneID" id="20671699"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_332054"/>
    <dbReference type="HOGENOM" id="CLU_091772_0_0_1"/>
    <dbReference type="InParanoid" id="W4JQ69"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW75026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="186" mass="20704" checksum="2BC703E8ECDA17DA" modified="2014-03-19" version="1" fragment="single">YSPLQLGAALQPFPERLFHRVSQLRRSCVMSLTLRTKLHVELLTAFLNARGPRAILSSDSYPLDHSPVVIELLFGTVSVPVASLSLRSTPTPCLTPHSLSLPSPLSIIATTLPGPRRPRPGFVSKACGFWSLVMRQPLLARRRSLLTQGRWQSGRGMLRRLLVRSYFQLRTSSEALRTTPSLFGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQ86</accession>
    <name>W4JQ86_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_460980</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551962.1">
        <property type="nucleotide sequence ID" value="XM_009553667.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="W4JQ86">
        <property type="interactions" value="930"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JQ86"/>
    <dbReference type="GeneID" id="20677129"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_460980"/>
    <dbReference type="eggNOG" id="KOG0951">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000335_1_0_1"/>
    <dbReference type="InParanoid" id="W4JQ86"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18019">
        <property type="entry name" value="DEXHc_Brr2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18021">
        <property type="entry name" value="DEXHc_Brr2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000002">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000368">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000254">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000013">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048863">
        <property type="entry name" value="BRR2_plug"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21188">
        <property type="entry name" value="BRR2_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="503"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="726"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="1351"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="213"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2140"/>
            <end position="2165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="213"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="2144"/>
            <end position="2165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW75698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="2165" mass="244155" checksum="D3A6BAC44D8D4297" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQE6</accession>
    <name>W4JQE6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_162529</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552021.1">
        <property type="nucleotide sequence ID" value="XM_009553726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQE6"/>
    <dbReference type="GeneID" id="20667778"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_162529"/>
    <dbReference type="eggNOG" id="KOG1804">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001666_6_3_1"/>
    <dbReference type="InParanoid" id="W4JQE6"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049080">
        <property type="entry name" value="MOV-10-like_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418">
        <property type="entry name" value="CANCER/TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418:SF1">
        <property type="entry name" value="CANCER_TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21634">
        <property type="entry name" value="MOV-10_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase MOV-10-like beta-barrel" evidence="12">
        <location>
            <begin position="426"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="10">
        <location>
            <begin position="557"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="11">
        <location>
            <begin position="713"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW75763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="991" mass="111285" checksum="E8D2AB857B89B74E" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4JR46</accession>
    <name>W4JR46_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_442343</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552266.1">
        <property type="nucleotide sequence ID" value="XM_009553971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JR46"/>
    <dbReference type="FunCoup" id="W4JR46">
        <property type="interactions" value="406"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JR46"/>
    <dbReference type="GeneID" id="20675438"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_442343"/>
    <dbReference type="eggNOG" id="KOG0829">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080773_1_1_1"/>
    <dbReference type="InParanoid" id="W4JR46"/>
    <dbReference type="OrthoDB" id="1294322at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002190">
        <property type="entry name" value="Ribosomal_L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="5">
        <location>
            <begin position="4"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW76042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="170" mass="20126" checksum="04324963CA9D6EE7" modified="2014-03-19" version="1">MGLTEYQVVGRHLPTESEPTPKIYRMRIFAPNEVVAKSRFWYFLRKLKKVKKANGEIIGVNVIHEKKPLKVKNFGIWIRYDSRSGTHNVYKEFRELSRADAVKSLYQDMAARHRARFRSIHILRVVEIEKTDDVRRPYIKQLLQPNLRFPLPHRVSKARSTFAAHRPVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JR67</accession>
    <name>W4JR67_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_331280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_331280"/>
    <dbReference type="HOGENOM" id="CLU_1735790_0_0_1"/>
    <dbReference type="InParanoid" id="W4JR67"/>
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    </dbReference>
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    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW75361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="151" mass="17257" checksum="4B6D1DFF660C6E18" modified="2014-03-19" version="1" fragment="single">VLACDNIGQITYGTSARISGFQSETMIKAVKYERNVIDITHQSWTYLVLINGNITSEAESNNKGDIYMIYKKGKEYLVFLAEQSIKSTKSIKKEAFDGIYLPKHSQVQLYPRPQESWAMQALRIPEEWLGHPRLKIPPNKLLKLAKLSMIP</sequence>
</entry>
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    <name>W4JRE9_HETIT</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">HETIRDRAFT_162810</name>
    </gene>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
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    </organism>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Duplessis S."/>
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                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="20667794"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_162810"/>
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    <dbReference type="InParanoid" id="W4JRE9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="58" mass="6682" checksum="CED9C28AF26B2909" modified="2014-03-19" version="1">MVLLPRAYEFGTHKDDGFSEKRVVQPTRCLLIKTCLDMISIFRPDQDHGCPRGFLEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRP4</accession>
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            <taxon>Heterobasidion</taxon>
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    </organism>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
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                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552416.1">
        <property type="nucleotide sequence ID" value="XM_009554121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRP4"/>
    <dbReference type="GeneID" id="20671582"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_330513"/>
    <dbReference type="HOGENOM" id="CLU_2542844_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRP4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="83" mass="9746" checksum="BEE43A6E404CD75B" modified="2014-03-19" version="1">MRELTQAPCLNYENNKHLHCFPSYAGDASDPHHQSEHMTISDLYPTRDTFIGGQRTNRIDSSYRHSPEQHSDRCNCRRDSFYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSC3</accession>
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        <recommendedName>
            <fullName evidence="10">PRP3-domain-containing protein</fullName>
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    <organism evidence="8 9">
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            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="ETW76005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552231.1">
        <property type="nucleotide sequence ID" value="XM_009553936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSC3"/>
    <dbReference type="FunCoup" id="W4JSC3">
        <property type="interactions" value="574"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JSC3"/>
    <dbReference type="GeneID" id="20675710"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_446772"/>
    <dbReference type="eggNOG" id="KOG2769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015750_2_2_1"/>
    <dbReference type="InParanoid" id="W4JSC3"/>
    <dbReference type="OrthoDB" id="10264544at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24162">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013881">
        <property type="entry name" value="Pre-mRNA_splic_Prp3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027104">
        <property type="entry name" value="Prp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212">
        <property type="entry name" value="U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08572">
        <property type="entry name" value="PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor 3" evidence="7">
        <location>
            <begin position="218"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="6">
        <location>
            <begin position="447"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="51"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="163"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW76005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="610" mass="67937" checksum="52FB66E942C6F67B" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSJ4</accession>
    <name>W4JSJ4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_329440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS26 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552076.1">
        <property type="nucleotide sequence ID" value="XM_009553781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSJ4"/>
    <dbReference type="FunCoup" id="W4JSJ4">
        <property type="interactions" value="356"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JSJ4"/>
    <dbReference type="GeneID" id="20671494"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_329440"/>
    <dbReference type="eggNOG" id="KOG1768">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129451_1_0_1"/>
    <dbReference type="InParanoid" id="W4JSJ4"/>
    <dbReference type="OrthoDB" id="10262653at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1740.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.20">
        <property type="entry name" value="Ribosomal protein S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000892">
        <property type="entry name" value="Ribosomal_eS26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047864">
        <property type="entry name" value="Ribosomal_eS26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038551">
        <property type="entry name" value="Ribosomal_eS26_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01283">
        <property type="entry name" value="Ribosomal_S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00733">
        <property type="entry name" value="RIBOSOMAL_S26E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW75826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="121" mass="13401" checksum="97A0660489C1A0E0" modified="2014-03-19" version="1" fragment="single">NGGRNKKGRGHVVFLRCSNCSRAVAKDKAIKRFTVRNMVESAAVRDISEASVYPEYVIPKLYIKIAYCVSCAIHSHVVRVRSREGRRNRAPPPRVRWKDGKKVNPAVVAAEEAKAAAARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTE6</accession>
    <name>W4JTE6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HETIRDRAFT_421852</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. SEC13 is required for efficient mRNA export from the nucleus to the cytoplasm and for correct nuclear pore biogenesis and distribution.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551293.1">
        <property type="nucleotide sequence ID" value="XM_009552998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTE6"/>
    <dbReference type="FunCoup" id="W4JTE6">
        <property type="interactions" value="680"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JTE6"/>
    <dbReference type="GeneID" id="20673754"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_421852"/>
    <dbReference type="eggNOG" id="KOG1332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032441_0_0_1"/>
    <dbReference type="InParanoid" id="W4JTE6"/>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000904">
        <property type="entry name" value="Probable SEC13-protein transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="13" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="6 18" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="18">
        <location>
            <begin position="10"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="18">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="18">
        <location>
            <begin position="218"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ETW76375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="329" mass="35523" checksum="427BC86AE4700C6B" modified="2014-03-19" version="1">MPPADPLPIETAHEDMIHDAQLDYYGKRLATCSSDRTVKVFDIVDGEQQRGTGQTLKGHTGPVWQVAWAHPKYGHILASCSYDGKVLIWKEQQSNAEGWAKIKEHSLHAASVNSVSWAPHELGAILACASSDGKISVLTFKNDGQWGADVFEAHAIGCNAVSWAPATRPGALLAPASTAPGQPSSAPVKRFVSAGCDNLVKIWAYSEETQTWTEEDVLEGHTDWVRDVAWAPNIGLPRSYIATASQDKTVLIWTKDTPTSHWTRTALDPTSISPTGAPPAAPGKFPDVVWRVSWSLAGNILAVSCGDGKVTLWKESLKGGWECVSDMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTV7</accession>
    <name>W4JTV7_HETIT</name>
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            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
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    <gene>
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    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009552251.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="20671320"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_327345"/>
    <dbReference type="eggNOG" id="ENOG502S3G3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047029_1_0_1"/>
    <dbReference type="InParanoid" id="W4JTV7"/>
    <dbReference type="OrthoDB" id="8955945at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="245"/>
            <end position="319"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
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        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW76988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="319" mass="35775" checksum="E3CF8F3DE677F129" modified="2014-03-19" version="1">MSGQASTSTDPPSATVQPGRGKVKLLDNYTGNRIESQKFMLQCLLLFAAESDRYKTDQDKISLVLSCMRYGTAGAWAENFLLKSVGADPPTDLGTWRDFLTKFKLQFRETGKTDKARSALMAFSQGRMTVDEYSNQFILIATDADISDKEQVPYFQRGLDPRVMDKIYDKEVQPKDTIQDWINTACEIDGRLRARSAQKAILANSTSFRSDYLNRFHTQPAVRYNSTTAPRRMNNQVVDMDIDTTRKRNAESQKRKFDGKQTTSCSNCGKPGHASANCWSPRRGVRPVRGNSKRRLGTTGRGNRAVDLEGEDDAPAILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUK8</accession>
    <name>W4JUK8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_436614</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551633.1">
        <property type="nucleotide sequence ID" value="XM_009553338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUK8"/>
    <dbReference type="STRING" id="747525.W4JUK8"/>
    <dbReference type="GeneID" id="20674900"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_436614"/>
    <dbReference type="HOGENOM" id="CLU_1090127_0_0_1"/>
    <dbReference type="InParanoid" id="W4JUK8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844967" evidence="2">
        <location>
            <begin position="22"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW76760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="255" mass="25196" checksum="C88DB118CB0772F1" modified="2014-03-19" version="1">MMQGFVVIALFLTVLARGAKAAPEVARRQVSSSLLLTPPIATSAFTTVSVASTESLPSVSDGTTSTAPTTLSHTGASITTHTGTHTGTLTAIHTATHTGTNSGSHWETHTGTHTGTHTGTHTETDTGSISGPSLPLSVSTIASSVLFSTTGTGSDLPSQSTDSATITSPTTSLPTVSPPTLTVPTSTLVSSSVATITSPVTSSPATSSTVEATSTSAAASTSATSARNSGVINMEASKAAMVMAGVAGAAVMFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUU0</accession>
    <name>W4JUU0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_174712</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551548.1">
        <property type="nucleotide sequence ID" value="XM_009553253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUU0"/>
    <dbReference type="GeneID" id="20668525"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_174712"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="W4JUU0"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF49">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="78"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW76666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="455" mass="49817" checksum="EF10371E0D756A2B" modified="2014-03-19" version="1">MPLDSEKNLLPMARATPETPEAEDKERGFSPTPNSLKTVGVERTICVQEVDVSDDAYVMDPIAEKKLVRKIDIRIIPAMMAIHTLNFLARANIGNAKVLNANNGHSLDETIHVTDKQYLDALMIFFVAYSIFETPSNYMLKRFFPSRWFAFLMLGWGAMVMILGGVQNFGGLVAVRFLLGAFEAGLFPGIIYFLTFWYPPHERASRTALIVTGASMGGAFGGSIAFGIGNLDGVKGIEAWRWLFILEGIPSVACAILVFFFFPDYPESAKWLSEEERKLSLHRLKGNSSSGHARISWAETEATLTDGRLYLHYLAYVSQCVPFSSISLFAPTIVAGLGYQGLDAQLFTVPPFAIAFVVTVSVSRMADKYQSWSLGSVIALTMAGVSFLVQVVTGALPPTAFKARYAMLCLASSFTYSVNPCLLSWLTANLRNTSATTLAVALNFTLGNIGQIIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4JV94</accession>
    <name>W4JV94_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_436311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550965.1">
        <property type="nucleotide sequence ID" value="XM_009552670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JV94"/>
    <dbReference type="GeneID" id="20674882"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_436311"/>
    <dbReference type="HOGENOM" id="CLU_2654797_0_0_1"/>
    <dbReference type="InParanoid" id="W4JV94"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW77462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="76" mass="8442" checksum="2CE0D2ED6696AA04" modified="2014-03-19" version="1">MDDISRASVERQSRIVTWCIFRTQILAETPFRTKCDRSPRAGPGVARGAYCSLSYMTFSITPASSSVHSARRSLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVA9</accession>
    <name>W4JVA9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_421637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551009.1">
        <property type="nucleotide sequence ID" value="XM_009552714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JVA9"/>
    <dbReference type="GeneID" id="20673738"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_421637"/>
    <dbReference type="HOGENOM" id="CLU_664032_0_0_1"/>
    <dbReference type="InParanoid" id="W4JVA9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW77513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="414" mass="45615" checksum="9A677801D31B39EE" modified="2014-03-19" version="1">MITNQRLFRDLYRNVMNQNYSIFTEHLFDVVQIAAERELTADLPTPSDGIAIAWNAVSNATIPRKANKSRRNFVQDSRTALRLNRKVHYSPVSDPPLDLDLGALIQTHAILSWQCQKLIDAGVDLNMLSPGMTDATTNEDTCVELDSPSEPGATTCGVCHANAKVDGVINHGCILFSQSARETVLSMRAGTQVYAKCVARQLVGHGMRSEVMARRAAALCKDILKELRADGPHDLVKAFSREARHELLTIFNQHWHPLYGQWRVGGSKTIQVSDLRKLGTTLSKAVAIFLDEGVARVTDVHDCLDILAKGAPWKVHLAAMHTMFTSITCAKMCKGKSKDRALHFRATVLERKSKDELSAWGSSPAVREMIQVSDAKCPRSPEVSTERHGAYAQDITSVIDSWSQKPTAGATLAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVF5</accession>
    <name>W4JVF5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_328917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551703.1">
        <property type="nucleotide sequence ID" value="XM_009553408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JVF5"/>
    <dbReference type="GeneID" id="20671455"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_328917"/>
    <dbReference type="HOGENOM" id="CLU_669138_0_0_1"/>
    <dbReference type="InParanoid" id="W4JVF5"/>
    <dbReference type="OrthoDB" id="3052275at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="431" mass="49540" checksum="EAA7B49629651A02" modified="2014-03-19" version="1">MPVLITSNTLQRTISRTINEWTDTYGMSPIQPSSIRFYDQTPPSLKPLADGPHRWLFEAKQSVGYDGRAGLNIRSIVKLLQSHRAYNRQPLLIPEDWKNADSNTDVDSVITILQNSVCHYIDHLHTIWPSTAPVEFYKPRSYFSTVPYPFPNVTLHELRDPQDVQYSVEWTILKILSKAHMGVVQYSTLGVTTFYDALLPAICYQIRGCEVLRSTPITFPPYSAEYGSSTCLDFVCRPSSDNLPNGLPSGFIPVLFAAHHLDALHTFTEDELSWSRPGPPEKMPDRSQELVKLAQVFQPSLQLLVMYLTKKYRVGDQQWKPEWNPIIAQEECFYLRPQIPENFFFYGMNYSQVECIIYAFFPRYEVTSSGRVEWGFCCYEAYTPWPTGGGNLTHRIHFINTILRIQRHTAELAELFREISLSLGTNDICRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVI7</accession>
    <name>W4JVI7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_441859</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550993.1">
        <property type="nucleotide sequence ID" value="XM_009552698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JVI7"/>
    <dbReference type="STRING" id="747525.W4JVI7"/>
    <dbReference type="GeneID" id="20675393"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_441859"/>
    <dbReference type="eggNOG" id="KOG2742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_3_1_1"/>
    <dbReference type="InParanoid" id="W4JVI7"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF5">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="3">
        <location>
            <begin position="155"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW77494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="39432" checksum="FAE00BEA654568BF" modified="2014-03-19" version="1">MASDAPGFAILGAGIFAKEAHLPAIASLAGSNISPVLKAVYSRSEKSALDLAAAANNTLKLATPPSIYHDGDPSTDLDALLARSDIRAVIVVLPITTQPSIVLKALAASKHVLSEKPIAADVAGAIELIRKYESEYKPKGLVWRVAENYETEPIYQRAAQAIRDGKIGKVLFFKARVTNYMDKDSKWYKTPWRTVPDYQGGFLLDGGVHFAAALRIMLPSPLTHLSAFTSLSKAHLAPKDTIHAIAKSAHDGAHGLFEVTFAAPSNEYTPGNGYTITGSTGWLTVGAAAVEEGKKQAMQLVLHNERGEGEVIVEESTGVSDEVRSFFGAVIGNDDEKQNPRSALRDLAFIQAALNSEGSLVDLEALSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVR5</accession>
    <name>W4JVR5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_453815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549696.1">
        <property type="nucleotide sequence ID" value="XM_009551401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JVR5"/>
    <dbReference type="GeneID" id="20676436"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_453815"/>
    <dbReference type="HOGENOM" id="CLU_2812684_0_0_1"/>
    <dbReference type="InParanoid" id="W4JVR5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="67" mass="7545" checksum="DDF0057222B1D9DA" modified="2014-03-19" version="1">MASRSTSTCVLARLDDADNHDNEEEDEEEHRRGKETVDEDIYKAAPSSRPLNLSHIRPALPSDPLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVU3</accession>
    <name>W4JVU3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_67107</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549670.1">
        <property type="nucleotide sequence ID" value="XM_009551375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JVU3"/>
    <dbReference type="GeneID" id="20678796"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_67107"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="InParanoid" id="W4JVU3"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="15"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW77683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="502" mass="55012" checksum="DA2FBDA924D6A300" modified="2014-03-19" version="1">MYTTSLRGKWLVIAITACCCQGFLLLGYDQGVMSGIIGADNQFGRDFGNPNPTTQGTIVAIYDIGCAVGSLFVFVFGERIGRKRMIMAGAITMIIGTAILTSSTTRAQLYAGRIVTGIGNGFNSSSIPVYQSETCGAHIRGSLVCLNSTITIVGLVIAYWLDYGMSFVSGPAQWRLPVGFQAFFAVCLLLQGMVLPDSPRWLIARGRIEEGTRILAQLEDKELDDPEVLEKKKEIEVSLMQESAGGPFRYRELLEGGPLGNFRRICLCVGVNVMQQFTGANMINYLAPIVYQNTMGLSRNLSLLLGGGTACTYMVASFIPLWTVDRFGRRPLLMISAAGQSLCFIIVSILLSTGSTNAAYGATAFVFIFQIFLGIGYLPIPWLYPAEITTTRIRSRGSAIASFFNWMCVFAVVEMTPPAIANINWKVFIIFAITNALWVPLVYAFFPETKGLELEDIDYIFEKGGITGGVWSSKGGRTVEKRKLAKDVEIMEKEKDSMQDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXJ3</accession>
    <name>W4JXJ3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_436027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550257.1">
        <property type="nucleotide sequence ID" value="XM_009551962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXJ3"/>
    <dbReference type="GeneID" id="20674863"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_436027"/>
    <dbReference type="HOGENOM" id="CLU_2320704_0_0_1"/>
    <dbReference type="InParanoid" id="W4JXJ3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="99" mass="11330" checksum="713F44C206092B3E" modified="2014-03-19" version="1">MLNHLSAQCCEQTHENEENKAHWRQVCALQIGGGGRRGVCGVIFRRHRRRGSCRCLPDRRLWGDGIVLQGHDPRIVACVTHVRVRIVLRPRHARACLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXW0</accession>
    <name>W4JXW0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_326357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549940.1">
        <property type="nucleotide sequence ID" value="XM_009551645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXW0"/>
    <dbReference type="GeneID" id="20671233"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_326357"/>
    <dbReference type="eggNOG" id="ENOG502RDJW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060803_1_0_1"/>
    <dbReference type="InParanoid" id="W4JXW0"/>
    <dbReference type="OrthoDB" id="2562239at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="293" mass="32134" checksum="7E2897D814DE37D0" modified="2014-03-19" version="1">MSNITSSIGSLTGGLPTVSQDMAPTIIFLVLYILTTALCFYRLTTQYRRPTRLFFTFVRFPLFELARIATFIMRALLAENFTKVLKGQASINKNLIIGEQILLGIGFLIPASVLVRLAGFHGSRFEGGDILGGRRRATWFLEIMLIVAIAFGIIAGTNFSGALTDPSKAKDVKHDRVISSAITLAVLVILVFYCISLASRPNFPRATSLWLGLTSALLIIVPAYRIHNTLNPPASADSAASKAEFYILQITVEWLVGASILAVNVKEWCGIQDTSYLDPADVQTQKVYLMQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXX9</accession>
    <name>W4JXX9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_244356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550279.1">
        <property type="nucleotide sequence ID" value="XM_009551984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXX9"/>
    <dbReference type="STRING" id="747525.W4JXX9"/>
    <dbReference type="GeneID" id="20669046"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_244356"/>
    <dbReference type="eggNOG" id="ENOG502RCQH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_4_5_1"/>
    <dbReference type="InParanoid" id="W4JXX9"/>
    <dbReference type="OrthoDB" id="368909at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06168">
        <property type="entry name" value="LSMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034110">
        <property type="entry name" value="LSMD1_Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF5">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 38, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="77" mass="8623" checksum="74E6B1E5814DE2D9" modified="2014-03-19" version="1" fragment="single">PSPFMADALKPLLRRPLRVTIADGRIFLGTFVGTDKALNLLLVNTDEFRLGPAENPHGRYVGQVMIPWPRIVRVEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4JY79</accession>
    <name>W4JY79_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_446181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550380.1">
        <property type="nucleotide sequence ID" value="XM_009552085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JY79"/>
    <dbReference type="FunCoup" id="W4JY79">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="GeneID" id="20675672"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_446181"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_0_0_1"/>
    <dbReference type="InParanoid" id="W4JY79"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="371" mass="41311" checksum="EFE061C75D73DAAD" modified="2014-03-19" version="1">MSSPSPQLFQPLTVGNLVLQHRVVMAPLTRFRANAQHIHTDIAVKYYTQRASIPGTLIISEATFIAPQAGGYANVPGIWSDEQIASWKKVTDAIHAKGSFIYIQLWALGRAADPAQLVLEDSSFQAVSSGNIRMGGREAAPRPLTVDEIKEYVQFYATAASNAVHKAGFDGVEIHNANGYLPDQFLQDVSNNRTDEYGGSIENRARFGLEVIDAVTKAVGEKIVGIRFSPWSEFQDMGMKDPIPTFSHMIETIRDRYPDFGYIHLVEPRINAAVDIEVKQGQTNEVFRKLWGSKVYLTAGGYKKEDALKAAETDNTLVVFGRYFISNPDLVLRLKEDIPLTMYDRNAFYAHTVPEGYIDWPFANEMEAAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZ86</accession>
    <name>W4JZ86_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_240265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Putative oxidoreductase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550369.1">
        <property type="nucleotide sequence ID" value="XM_009552074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZ86"/>
    <dbReference type="GeneID" id="20668852"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_240265"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056799_1_0_1"/>
    <dbReference type="InParanoid" id="W4JZ86"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW78395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="33059" checksum="0FA5E3306C988252" modified="2014-03-19" version="1" fragment="single">SLPLGWLALKRLSHARRSDTIPRHAERVLVIGASSGIGRAIALRYAERGAKLCLVGRRAVELEDAREECGAVQKEAGRVHSSGVLSVVADFADAGDMVRVREILDKEWGGLDTLVVSAGVSALQPLMHLAGVEGRSIDADAPTVEGIRNTADIASAATRGNYLGPLVSAVTLIPFLSKSPSPSILLISSLAAAIPAPTRTLYTSTKAASFMLYRSLSIEHPNITFSYILPSTVEGDFRASAVDSGPVRETDPNKHGLKRAAVAARSVRAIDDGEGTVFMPAFYWWAHLLYWFFPSFVGRQASRKYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZB1</accession>
    <name>W4JZB1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamate-5-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="2">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_64127</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="2"/>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548805.1">
        <property type="nucleotide sequence ID" value="XM_009550510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZB1"/>
    <dbReference type="FunCoup" id="W4JZB1">
        <property type="interactions" value="272"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JZB1"/>
    <dbReference type="GeneID" id="20678668"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_64127"/>
    <dbReference type="eggNOG" id="KOG4165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030231_0_1_1"/>
    <dbReference type="InParanoid" id="W4JZB1"/>
    <dbReference type="OrthoDB" id="1934954at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000006">
        <property type="entry name" value="Gamma-glutamyl phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001221">
        <property type="entry name" value="PRK00197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063:SF8">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063">
        <property type="entry name" value="GLUTAMATE SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="12">
        <location>
            <begin position="5"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW78789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="459" mass="49257" checksum="5BD02FEEE7EF143A" modified="2014-03-19" version="1">MPSDTSAAEAIAKAAKTAFEASQLIPTSERVRALHEIRNELEASKASILAANKEDMDAAQVEVDAGRMSTSLLNRLDLRKGDKWDSMLQGVTDVANLTDPTGKVSYASELDDNLEIYRVSCPIGVLLVIFEARPEVVVNIAALAIKSGNAAILKGGKESNRSTQLISKAIQTALSRTNLPNTYIQTIQSRAEVNSLLYLDQYIDLVIPRGSNELVRNIQNNTRIPVMGHADGLCAIYLDESADSEKAVRIVVDSKIDYPAACNAVETLIVHESLLSTVWLDVAKALLNASVTLLCDPPTLAALDKLSPAPSNRLTHVRPAPPDAYTTEHLSLTLSVLTLPSLPAAMQHINAHSSHHTDCIVAEDVAAASTFTRGVDSAGVFVNASTRFADGFRYGFGTEVGISTGRIHARGPVGLEGLVTYKYVLRSKGENGHVVGEFGSGEGKKRYKHAPIHANSVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZC7</accession>
    <name>W4JZC7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_109035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550410.1">
        <property type="nucleotide sequence ID" value="XM_009552115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZC7"/>
    <dbReference type="GeneID" id="20666403"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_109035"/>
    <dbReference type="HOGENOM" id="CLU_1886030_0_0_1"/>
    <dbReference type="InParanoid" id="W4JZC7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="135" mass="15182" checksum="37438CC679946793" modified="2014-03-19" version="1">MENFRCLTRDSNNKAVYGPWDRSNVVEMGGQQGPGRRRHPLVYCQDAHHSLAEEVHDYCERLRNYLVAEELQGRRGWVWSPATIVSPLGAPIVVKYKPGSLAAEQYGSQLVHVLCVVPDTQDAMRFLMGMGQLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4K009</accession>
    <name>W4K009_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ER transporter 6TM N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_479600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550406.1">
        <property type="nucleotide sequence ID" value="XM_009552111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K009"/>
    <dbReference type="STRING" id="747525.W4K009"/>
    <dbReference type="GeneID" id="20677878"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_479600"/>
    <dbReference type="eggNOG" id="KOG4711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003918_1_0_1"/>
    <dbReference type="InParanoid" id="W4K009"/>
    <dbReference type="OrthoDB" id="2274698at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF1">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </location>
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        </location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="824"/>
            <end position="842"/>
        </location>
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        <location>
            <begin position="78"/>
            <end position="533"/>
        </location>
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        </location>
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        <location>
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        </location>
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        </location>
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        </location>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF10337"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="ETW78436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1091" mass="122541" checksum="555C2500818D9F93" modified="2014-03-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
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                <person name="van Diepen L.T."/>
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                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
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                <person name="Raffaello T."/>
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                <person name="Salamov A."/>
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                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">TC 32-1</strain>
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    </reference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_104409"/>
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    <dbReference type="InParanoid" id="W4K054"/>
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        <source>
            <dbReference type="EMBL" id="ETW79109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0W9</accession>
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    </organism>
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                <person name="Asiegbu F."/>
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                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="Karlsson M."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
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    </dbReference>
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            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW79442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="162" mass="16192" checksum="CE6EBFCF0EA54FCA" modified="2014-03-19" version="1">MGRPKHPVRGPPPINRPPSKGKTSASKMKGSNTRDPRGDNPSARDASPGSSIGGCARDLNARTLYTRGIDVLVGHARDHNVTGGNVTGSNTTGGNSACKYVAGCGNATVGHALGGNSVSEHIAGGSNMLGGNVLVSDALGRNSGGGHISGRIAMVVKGMVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
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                <person name="Karlsson M."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
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                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Velez H."/>
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                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="22463738"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="20670925"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_322943"/>
    <dbReference type="eggNOG" id="ENOG502SQ8R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045560_0_0_1"/>
    <dbReference type="InParanoid" id="W4K0X2"/>
    <dbReference type="OrthoDB" id="3133596at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="400" mass="45108" checksum="70F0D9E433D7E37E" modified="2014-03-19" version="1">MSPIILDTVGPLSCGSTSTPIAFRAVNARYSFSLDTKRREAQVKDAIPPNAQDVANCIVTGDSATESPIHLCHVSHERHWSNHHMLNLSRLERAWGMKYDTIQMDGESNTISRAYSSLRYFLSLTLWDRWVKFDPLDGHVPSIEDMYDGAETFEYRLVPLFPDVPSISHRNKAEDGPESDESSGNPVHSYPFDYLPPIFSRVKSHFVVYDAGRKIDSISLQTYRTTSDIARIYGVSQEKAERVTTVVYAAYCTWSNHVHPATFVISPRIIDSRSRSSLIRPGQPNCAPQAGRPKKRCRATGEVIDAVYLQPNVVRYATSLSRVSPCGSDVLIVGDPGWDTEVDAEYEKKQLHRVIKASKRWARECHRESLSSGGWVSCLTHDEQLKSYRQEPSWPVLSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4K213</accession>
    <name>W4K213_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_321448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548376.1">
        <property type="nucleotide sequence ID" value="XM_009550081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K213"/>
    <dbReference type="GeneID" id="20670753"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_321448"/>
    <dbReference type="HOGENOM" id="CLU_2229486_0_0_1"/>
    <dbReference type="InParanoid" id="W4K213"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="106" mass="11552" checksum="FDBE01AA50765473" modified="2014-03-19" version="1" fragment="single">PTIKFCSLGQDLKATVSYSVPNFMADMADKDMLTFNSSNTNNNSETNDTDGPEAALLCWASMLKIVKEFGIHDKVFINLLSDTPRYLLLATLPPPPPVIPPSIPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4K253</accession>
    <name>W4K253_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_452881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548343.1">
        <property type="nucleotide sequence ID" value="XM_009550048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K253"/>
    <dbReference type="GeneID" id="20676308"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_452881"/>
    <dbReference type="HOGENOM" id="CLU_760879_0_0_1"/>
    <dbReference type="InParanoid" id="W4K253"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="364" mass="39042" checksum="CD3BC39D2C1F3642" modified="2014-03-19" version="1">MPVLFSPTFALPIDSSSGDGAGSAGDYGGTGSGHSGGSNGDKDAGNDRAAGSLPTRSCKVSVWTRTSGGDATSLTGSVPEVADWLLLRVCAVVRACHAFRQTHGEIRKRQAQARSGPTVAVDAVVGEVMRLQGGRASEASLQDDARPATNQNQAKRQPQSKGRIRLLEFRRLTQAHRRSGDRRRSLTLSPSSVLQQGRERRARCSYAAARGDAACFESPEVLRATLVGREGDQNGRTAGTHTRPLKKGEQRKTVRQAVYNGRRYSKRSMATSAGKHIDSAAQAASCRVQNTRTVRVPDMADRQANRVGSQAMSRQAVGQLSPYAHVSCIYNVHAPVVPTSQDFNLTSIHRHGLAHAARRTPTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2C3</accession>
    <name>W4K2C3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_322564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548480.1">
        <property type="nucleotide sequence ID" value="XM_009550185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2C3"/>
    <dbReference type="GeneID" id="20670877"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_322564"/>
    <dbReference type="HOGENOM" id="CLU_2694487_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2C3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="84" mass="9500" checksum="1138B02048629DE9" modified="2014-03-19" version="1" fragment="single">PLEWDVFLRKVVKGSSRSGEVFDEPAIEVSKAQEGLYFLQVLRSWPGGDSINLDGVHRYIVRGDDESEVFDRVCFESAFGGFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2H7</accession>
    <name>W4K2H7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Phosphatidylethanolamine N-methyltransferase</fullName>
            <shortName evidence="13">PE methyltransferase</shortName>
            <shortName evidence="13 14">PEAMT</shortName>
            <shortName evidence="13">PEMT</shortName>
            <ecNumber evidence="13 14">2.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HETIRDRAFT_477618</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11164"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.1.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="13 14">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13 14">Endoplasmic reticulum membrane</location>
            <topology evidence="13 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13 14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.17" evidence="13 14"/>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548552.1">
        <property type="nucleotide sequence ID" value="XM_009550257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2H7"/>
    <dbReference type="FunCoup" id="W4K2H7">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K2H7"/>
    <dbReference type="GeneID" id="20677760"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_477618"/>
    <dbReference type="eggNOG" id="ENOG502QRGH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005987_0_1_1"/>
    <dbReference type="InParanoid" id="W4K2H7"/>
    <dbReference type="OrthoDB" id="4583at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
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</entry>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
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                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </source>
    </evidence>
    <sequence length="479" mass="52451" checksum="04F8172E347E09BE" modified="2014-03-19" version="1">MLLHEDHDASSPSRNSSPDVVLMVSNPDIGRVDRGTSPHPSNAGRIDRGTSPHHPEPAVVTLTPHLNNFSDDDAEDYAKLKERERTRRPSSQGPPRDASRNENPDDRNLPGSDEVLVGVSPPATIAASIGTAGPSGLRARTAAQLPSHGETESIPVIQGVTPPPVPTGGQIPRSMGRTTLGTNPHAGELERHADALLQRSTISAVIQMATAMALQRLTNFAAGQPGNEHSDIPRRLASASLQIRGLALQTDPDTASWYEHNDGRPRALLIHPDEFSQYVNRELLPALLFTGELGAVQPSRTDPFRVVVWNVPRPGEHPTAVPNPRRAPRTVVERPSPRPRESRPTHSNPTTSPSHRVRNFPLSHGGTDEEEPPVYRRNEGRRSRGTQATLLRGTTTGGSIRHQPGTPPPSARFRTDEGQNNRSSRRTRRADSEARRNRSWTRSELDAWDALDDPGNYDDADPYYRPDEGGDGYQGPYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4N1</accession>
    <name>W4K4N1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_22960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546882.1">
        <property type="nucleotide sequence ID" value="XM_009548587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4N1"/>
    <dbReference type="STRING" id="747525.W4K4N1"/>
    <dbReference type="GeneID" id="20668705"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_22960"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001324_5_7_1"/>
    <dbReference type="InParanoid" id="W4K4N1"/>
    <dbReference type="OrthoDB" id="3366231at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="1">
        <location>
            <begin position="277"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="445" mass="51054" checksum="491F6890F93082B7" modified="2014-03-19" version="1" fragment="single">CAHCNALHFKGERLVRSGIRNPRFGMCCLQGKISLPLLPEPPNTLRKLLMDPSTRSRNFRTQIRQYNSAFAFTSVALKLDENLLNRSGPYSFRLHGALSHRMGSLLPDDGQQPSYAQLYIHDPQAALATRSLRNPNLDHTILTELQAMLHEVNPYVPLYKQAYEILHDKPPDEQANISARIVVEPNTDHRRYNMPLVDEVAAVIPGSGEEVTREHRDIIVWLRGGHLQRISHLNPVYSPLHYILMFSHGEQGWHTKIPVTGDPDQRTRSPWVSQRCYYAYRLHPRILEPDTIFRCGRLFQQYVVDAWASIETSNLHWVRTHQKDIRADTYQGIRDAVNNADVNPDLAQQGTRIILPSTHSGSARHMYQLFQDSMSICRHCRKPDLFLTMTANPNWPEIQQALLELDHPIGNDPNNPPKRQTAADRPDIVARVFNQKKNALLKEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5C3</accession>
    <name>W4K5C3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aspartic peptidase A22B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_33841</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546903.1">
        <property type="nucleotide sequence ID" value="XM_009548608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5C3"/>
    <dbReference type="FunCoup" id="W4K5C3">
        <property type="interactions" value="169"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K5C3"/>
    <dbReference type="GeneID" id="20671765"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_33841"/>
    <dbReference type="eggNOG" id="KOG2443">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023799_0_1_1"/>
    <dbReference type="InParanoid" id="W4K5C3"/>
    <dbReference type="OrthoDB" id="29661at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF23">
        <property type="entry name" value="MINOR HISTOCOMPATIBILITY ANTIGEN H13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="355"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW81023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="411" mass="45385" checksum="9D2A64BD1E7D3162" modified="2014-03-19" version="1">MDVDLVSSYAGLLGLAVVSIYAGAFGSLSTPKRSNSSAQSLVLDDEDEDEDDGVDRLSSEDAWLFPVLGSVTLFGLYLVVKYLGKEWINWLLGWYFSIAGVGSVWKSLTSLVRFSLGRERWNKYEKNRVLFLRGPREIMAFSWRTPSLVLFPFGALPSILYTFSGSSKKSALLTDILSLSFSHNALSLLKIDSFKTGTILLSGLFVYDIWWVFGTEVMVKVATNLDIPIKLLWPKSIVFSTDRGFTMLGLGDVVIPGVFVALALRYDHHRHISSPGSSFTKPYFYATLAAYIAGLATTMSVMHVFKAAQPALLYLSPACILSFVLTASIRGELADAWKWSDVPPESPDKLKEILENEKTTHKDSALPPAETNLLEVPAPQVDAFASETDGEEGAEGEKAKAKKRKNKKKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5F2</accession>
    <name>W4K5F2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_427855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547717.1">
        <property type="nucleotide sequence ID" value="XM_009549422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5F2"/>
    <dbReference type="GeneID" id="20674233"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_427855"/>
    <dbReference type="HOGENOM" id="CLU_091438_1_0_1"/>
    <dbReference type="InParanoid" id="W4K5F2"/>
    <dbReference type="OrthoDB" id="3175502at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="177" mass="20316" checksum="CCFC7092EA2476F0" modified="2014-03-19" version="1">MASFIDSLTNAKHPIVLVQYKRDDLGQGDEPQLHWALHVITSSRRLSGPSFQVIDRVHQDERGKQWSLFYNPTDALIGNGKCLGGLQVGTVPHREVSALVDAVRAHEVKPKFEEWTCRDFVLELFELFKERGWMRKELADVAFNQKDLIPDLKVSSSATISQARERRSFVPYVMYYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5T1</accession>
    <name>W4K5T1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA repair and recombination protein RAD54B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_123162</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009549131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5T1"/>
    <dbReference type="STRING" id="747525.W4K5T1"/>
    <dbReference type="GeneID" id="20666812"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_123162"/>
    <dbReference type="eggNOG" id="KOG0390">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_10_1_1"/>
    <dbReference type="InParanoid" id="W4K5T1"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18004">
        <property type="entry name" value="DEXHc_RAD54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000020">
        <property type="entry name" value="DNA repair and recombination protein RAD54B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="419"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="747"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW80710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1037" mass="114946" checksum="FD77C0A0E8893BC1" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4K624</accession>
    <name>W4K624_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_246300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beclin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547247.1">
        <property type="nucleotide sequence ID" value="XM_009548952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K624"/>
    <dbReference type="FunCoup" id="W4K624">
        <property type="interactions" value="277"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K624"/>
    <dbReference type="GeneID" id="20669113"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_246300"/>
    <dbReference type="eggNOG" id="KOG2751">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024219_3_1_1"/>
    <dbReference type="InParanoid" id="W4K624"/>
    <dbReference type="OrthoDB" id="20368at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.40:FF:000006">
        <property type="entry name" value="Chromosome 12, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.40">
        <property type="entry name" value="Autophagy protein 6/Beclin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007243">
        <property type="entry name" value="Atg6/Beclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038274">
        <property type="entry name" value="Atg6/Beclin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041691">
        <property type="entry name" value="Atg6/beclin_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040455">
        <property type="entry name" value="Atg6_BARA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768">
        <property type="entry name" value="BECLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768:SF4">
        <property type="entry name" value="BECLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04111">
        <property type="entry name" value="APG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17675">
        <property type="entry name" value="APG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atg6/beclin coiled-coil" evidence="4">
        <location>
            <begin position="29"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Atg6 BARA" evidence="3">
        <location>
            <begin position="163"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="57"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW80511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="338" mass="39051" checksum="49B4F8780978AAC6" modified="2014-03-19" version="1" fragment="single">PNPSPLSHHLRSTQRLLNLLSSRTDIDHPLCSECTHILLTTLTRQLEETKKERDGYIAFEKEVRKEKEREKEGMSKEEAERKIAQLNEDEQLAIEQLREAEREQKQLQEEMKALELEEEALGDEEEEFWRIHNVQLLKSTEQSSQLSALRAAYAADSATLERLERTNVYNDAFCIGHDGVFGTINGLRLGRVPGVPVEWAEINAAWGQTLLLLYTIARKLDFTFENYRLIPMGSFSRIERIGGDKATYELYGSGDLHLGRLLHNRRFDFAMVAFLDCLKQLTDWTKSQDPSLEFPHQIVKDKIGESSVKLQFSQEEAWTRSLRHVLLALKILLKWTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4K629</accession>
    <name>W4K629_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RraA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_320400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547251.1">
        <property type="nucleotide sequence ID" value="XM_009548956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K629"/>
    <dbReference type="STRING" id="747525.W4K629"/>
    <dbReference type="GeneID" id="20670661"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_320400"/>
    <dbReference type="eggNOG" id="ENOG502RZ5Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072626_0_1_1"/>
    <dbReference type="InParanoid" id="W4K629"/>
    <dbReference type="OrthoDB" id="1476984at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047443">
        <property type="term" value="F:4-hydroxy-4-methyl-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.40">
        <property type="entry name" value="Ribonuclease E inhibitor RraA/RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254:SF4">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="96"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605493-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="23470" checksum="DC6D4EC9D7A7822F" modified="2014-03-19" version="1">MASPLAEYSTCELSDALLKLGVAHGGHIPDIRMISPSPSSTNAENVRICGPAYTVHMVLSTNPTAPKLNGHFVDLAPEGSVILIDAPSEAQNAVWGGLMTAGALARRCLGTIVSGRIRDTSEHRATSYPLFARGTSTVGQSPFTRPSLVDISVTIHTGGNLQPVTVNPGDWLVADIDGVVCVPKELAKQVAELAAGGHDVDARCLEDIQKGLGVANSFNMHRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4K636</accession>
    <name>W4K636_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_318077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545913.1">
        <property type="nucleotide sequence ID" value="XM_009547618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K636"/>
    <dbReference type="GeneID" id="20670472"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_318077"/>
    <dbReference type="HOGENOM" id="CLU_1829941_0_0_1"/>
    <dbReference type="InParanoid" id="W4K636"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="141" mass="15733" checksum="BD40A0F74104E9E1" modified="2014-03-19" version="1" fragment="single">RRSGLRSSGTTPALTSPTTPTQTAHAPQKSPANIQASYGRYERLRADESDYDYVAHTSFNGPTKIIEHREADIEQPQIADGEFYVRRAYSRLSKCATVSPHPHPSPSRSSQTPSNPHTFDVITNASKWTIFTTSARRERSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4K681</accession>
    <name>W4K681_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_409979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547311.1">
        <property type="nucleotide sequence ID" value="XM_009549016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K681"/>
    <dbReference type="STRING" id="747525.W4K681"/>
    <dbReference type="GeneID" id="20672821"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_409979"/>
    <dbReference type="eggNOG" id="KOG1674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018882_0_0_1"/>
    <dbReference type="InParanoid" id="W4K681"/>
    <dbReference type="OrthoDB" id="286814at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
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        </location>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="618" mass="65828" checksum="631F62AF80CB6BBD" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
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            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
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    </reference>
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    <dbReference type="Proteomes" id="UP000030671">
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    </dbReference>
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            <end position="173"/>
        </location>
    </feature>
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            <end position="26"/>
        </location>
    </feature>
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    </feature>
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        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="303" mass="32497" checksum="44CCE6C6BC30B92D" modified="2014-03-19" version="1">MPSQGLFGPWTLAPSDTTFIQRQVQSLAEREAQSGAPPQPLPQTQPQTTSSVPPVSPPQQQTQPDVQAQPQQQAPSGAAPTPQSGGTPLPPPPSFNSLNDFIPFQTMGMGPEGPWLQWSGTIPLGALPIFPTPRPHGNANTNTNPGPPGQNGHQFHAPPSKRAWALPPAPGPTLRQRLEQRERDAGWRCDDVSCGVGPSDEELFPAIATTESGRKRVSLRPYVPVGTVESGRVCAHQFHPACLVSAERVAGWGQEEDEEARRRSERRESVASGEHLVEVACPVCRAVGAVTSTEWDEGVRALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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            <taxon>Agaricomycotina</taxon>
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            <taxon>Russulales</taxon>
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            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="InParanoid" id="W4K7Z6"/>
    <dbReference type="Proteomes" id="UP000030671">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
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            <begin position="24"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW81869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="216" mass="21709" checksum="3485D33C6051DD81" modified="2014-03-19" version="1">MLSFSKIASFAVLTLSTLASVSAIPVVHHDARQLVDIPIIVDPTIAPVTTITARDGSQNLASIFANLHAALQPVLSGLSSTKDPVALESGIASITSLIQSASGSLSALSGQSQSQIFANLDGTGVLTTSDVAGLLGGVLTNVFGTLGPLTSGTDAIASLDVLDPLLGVVVIFLNVVLGLVGVAALALVGSLLPLILVLLPSILNILLPIILGLIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8A0</accession>
    <name>W4K8A0_HETIT</name>
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        <recommendedName>
            <fullName evidence="6">L domain-like protein</fullName>
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    </protein>
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        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009547497.1"/>
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    <dbReference type="STRING" id="747525.W4K8A0"/>
    <dbReference type="GeneID" id="20675765"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_44734"/>
    <dbReference type="eggNOG" id="KOG0531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008915_1_0_1"/>
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    <dbReference type="OrthoDB" id="7451790at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061499">
        <property type="term" value="C:outer plaque of mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031028">
        <property type="term" value="P:septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052574">
        <property type="entry name" value="CDIRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566:SF1">
        <property type="entry name" value="PROTEIN NUD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="452"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW82023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="549" mass="60570" checksum="3221FBDC374A5B64" modified="2014-03-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8W7</accession>
    <name>W4K8W7_HETIT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_101292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546774.1">
        <property type="nucleotide sequence ID" value="XM_009548479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8W7"/>
    <dbReference type="GeneID" id="20665755"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_101292"/>
    <dbReference type="HOGENOM" id="CLU_1886025_0_0_1"/>
    <dbReference type="InParanoid" id="W4K8W7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="135" mass="14993" checksum="10F42E72D00A2462" modified="2014-03-19" version="1">MRLLAALNSPSAPSLNTSMMTCHMTQYDRLHLAASVEAAAFLGRPSLFDLMAIIVELMERLSPAAIVIFFVGITFIRGFTDPIMPRLPPRTPCSRRRVPPLYGATHNHIQIKGQLAHNSDKGGQTTHKLMLLRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4K913</accession>
    <name>W4K913_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_475803</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAPRE family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546841.1">
        <property type="nucleotide sequence ID" value="XM_009548546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K913"/>
    <dbReference type="FunCoup" id="W4K913">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K913"/>
    <dbReference type="GeneID" id="20677648"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_475803"/>
    <dbReference type="eggNOG" id="KOG3000">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041744_2_1_1"/>
    <dbReference type="InParanoid" id="W4K913"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035372">
        <property type="term" value="P:protein localization to microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1430:FF:000005">
        <property type="entry name" value="Eb1, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000028">
        <property type="entry name" value="RP/EB family microtubule-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004953">
        <property type="entry name" value="EB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036133">
        <property type="entry name" value="EB1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027328">
        <property type="entry name" value="MAPRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10623">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03271">
        <property type="entry name" value="EB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140612">
        <property type="entry name" value="EB1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51230">
        <property type="entry name" value="EB1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="12">
        <location>
            <begin position="2"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="EB1 C-terminal" evidence="13">
        <location>
            <begin position="162"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="123"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW82312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="254" mass="28370" checksum="3EF8BFFE29D75CC7" modified="2014-03-19" version="1">MGESRSELIAWLNELLQLNYTKIEQCGTGAAYCQIIDSIYGDVPMVRVKMNAKHEYEFIANFKVMQNIFKAKRIDKPIPVERLVKCKMQDNLEFLQWLKRFWDSNYGGQPYDAVARRRGQSTDTPATIAPLAPARGGGGGGLSAGARSGGKTPVGGHRAGSSAAVHQEQVHNLQAQLKEVSAHLEGLEKERDFYFAKLRDIEILAQQQLEVLEGEGKDDETLREIQKILYSTEDGFEVPEGDAHAQLVDEEETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4K933</accession>
    <name>W4K933_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_173276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
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                <person name="Yakovlev I."/>
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    </evidence>
    <sequence length="516" mass="58570" checksum="2E85D7F81A3EA407" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9S2</accession>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
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                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546402.1">
        <property type="nucleotide sequence ID" value="XM_009548107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9S2"/>
    <dbReference type="GeneID" id="20676158"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_451507"/>
    <dbReference type="HOGENOM" id="CLU_2359992_0_0_1"/>
    <dbReference type="InParanoid" id="W4K9S2"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="96" mass="10259" checksum="E8673C7BE933E5B8" modified="2014-03-19" version="1">MAPSSLERCLSPSVHLLRPRTSHSFPHSHVLSPPLHLPSFQTTLSVHAPSPLPESSSAAVPHRFRAPRPTLPKLAPVIILITSINTTPSPSSVPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KA40</accession>
    <name>W4KA40_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_168832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546759.1">
        <property type="nucleotide sequence ID" value="XM_009548464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KA40"/>
    <dbReference type="GeneID" id="20668185"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_168832"/>
    <dbReference type="HOGENOM" id="CLU_3032610_0_0_1"/>
    <dbReference type="InParanoid" id="W4KA40"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="55" mass="6531" checksum="1A4E89F50DCAAD5A" modified="2014-03-19" version="1">MQSGMAKVHIALLSDSRDVQYTYHRIATDVPFRNHFTHEHQRLGVDRDHRIEMIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAF6</accession>
    <name>W4KAF6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_45723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545808.1">
        <property type="nucleotide sequence ID" value="XM_009547513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAF6"/>
    <dbReference type="STRING" id="747525.W4KAF6"/>
    <dbReference type="GeneID" id="20676805"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_45723"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_29_4_1"/>
    <dbReference type="InParanoid" id="W4KAF6"/>
    <dbReference type="OrthoDB" id="2273864at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="10"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="139" mass="15835" checksum="C32D722A0A77A737" modified="2014-03-19" version="1" fragment="single">HKGRIYVPPDDKLKRRITKMYHDSPATGHPGRWKTYILISDNFWWPGMSTFIKEYVTGCAICQNTKNITHPTRSPLIPNEIPEGPWQTVTMDFITDPPQVGPYNAIHVTVDRSTKGVVYTPCNKTIDAEGTTDLYMKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAF7</accession>
    <name>W4KAF7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_450541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545116.1">
        <property type="nucleotide sequence ID" value="XM_009546821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAF7"/>
    <dbReference type="GeneID" id="20676056"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_450541"/>
    <dbReference type="HOGENOM" id="CLU_1496404_0_0_1"/>
    <dbReference type="InParanoid" id="W4KAF7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="180" mass="19190" checksum="8330DE1879E57EB2" modified="2014-03-19" version="1">MNREGREGEPRKRAFVRSFGHSVVPSTILARSRPSRSRACARVRERALPGLPLPSPTSSTRAALSHTHHSDPVTQSPSHPATPPRSVHPPQRPTPTTATHTQLAHITRAPPVDGLPPSSSDLSPGDFAQGDSAARKRHRARSVGRSVGRSVGYAVCSVQGDAAPMLYGICDGTVRYGTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAK3</accession>
    <name>W4KAK3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_24630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAK3"/>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_24630"/>
    <dbReference type="eggNOG" id="ENOG502S3G3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_32_0_1"/>
    <dbReference type="InParanoid" id="W4KAK3"/>
    <dbReference type="OrthoDB" id="128646at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="96" mass="11176" checksum="B84752B073BEB919" modified="2014-03-19" version="1" fragment="single">IDSACEGVIVNETWVKRHRFPTYTLNNPIRVRNVDDTINKAGLIRSALDVNLTIRDISGRTHTERIQMFISNLGKDDLILGTDWLKYHDPSIEWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBX4</accession>
    <name>W4KBX4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_119547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545142.1">
        <property type="nucleotide sequence ID" value="XM_009546847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBX4"/>
    <dbReference type="GeneID" id="20666659"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_119547"/>
    <dbReference type="HOGENOM" id="CLU_1372361_0_0_1"/>
    <dbReference type="InParanoid" id="W4KBX4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="199" mass="21755" checksum="B8475A744351DC95" modified="2014-03-19" version="1">MSNRCQALAIREDKKPCDPSAAKCPLRGCMLISTPSIAVLHIRINDGLDMGANYQATKVGKVQLAFLQGDGMPGNKYSPSTQEILKDPVSECKACFMSENLKFRVVQYQTAALNESDAGMAMVENEDIMGLANLAKPPEAFGDWGSYSIETFAFVIGVGIGWAVAYKFKIQVPNADKVYFEQLEGVKEAVEFKLGLRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCM4</accession>
    <name>W4KCM4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_407990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543314.1">
        <property type="nucleotide sequence ID" value="XM_009545019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCM4"/>
    <dbReference type="GeneID" id="20672649"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_407990"/>
    <dbReference type="HOGENOM" id="CLU_1532755_0_0_1"/>
    <dbReference type="InParanoid" id="W4KCM4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="175" mass="18454" checksum="83E38F5D16D1E3D8" modified="2014-03-19" version="1">MPPPPPWASKWAGPTTVPVAGPSTASDTLGRVPHTPPPSTHLNRKRRFDDDASIDSADESPTRFEPAKRRTLSRTPVADLSSSSSSHAGPSSRPIQTLSPSLAILMSPETTRTSPRQGLPYGASGALSQSQSNNKRAPSLSPAPSSRKAMAVGYRAERNGKDGWEPSSTTPLPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCT7</accession>
    <name>W4KCT7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_62252</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543248.1">
        <property type="nucleotide sequence ID" value="XM_009544953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCT7"/>
    <dbReference type="FunCoup" id="W4KCT7">
        <property type="interactions" value="885"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KCT7"/>
    <dbReference type="GeneID" id="20678590"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_62252"/>
    <dbReference type="eggNOG" id="KOG1128">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004905_0_1_1"/>
    <dbReference type="InParanoid" id="W4KCT7"/>
    <dbReference type="OrthoDB" id="1936594at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044244">
        <property type="entry name" value="TTC27/Emw1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="510"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="595"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="699"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW83554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="853" mass="96278" checksum="8D29D803D6352BE0" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4KD32</accession>
    <name>W4KD32_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
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    </dbReference>
    <dbReference type="InterPro" id="IPR059169">
        <property type="entry name" value="GCP5_N_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF33">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="385"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="773"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="259"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1043"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1053"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW84094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1134" mass="127300" checksum="D744B065F767CA20" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEM0</accession>
    <name>W4KEM0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="10">dUTPase</shortName>
            <ecNumber evidence="10">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_425693</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="2">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the dUTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="10"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543950.1">
        <property type="nucleotide sequence ID" value="XM_009545655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEM0"/>
    <dbReference type="FunCoup" id="W4KEM0">
        <property type="interactions" value="1042"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KEM0"/>
    <dbReference type="GeneID" id="20674041"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_425693"/>
    <dbReference type="eggNOG" id="KOG3370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068508_2_1_1"/>
    <dbReference type="InParanoid" id="W4KEM0"/>
    <dbReference type="OrthoDB" id="419889at2759"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.40.10:FF:000004">
        <property type="entry name" value="Deoxyuridine triphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001862">
        <property type="entry name" value="PRK00601.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="11">
        <location>
            <begin position="35"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW84263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="170" mass="18140" checksum="A88A8F0E7B25B13F" modified="2014-03-19" version="1">MTNTPTIKRRRYSVDAEDVDTPSTSNLLIKRLSAKAKLPTRGSALAAGYDLYSAEKKIIPARGKALVDTQLSIAVPAGTYGRVAPRSGLASKFMIDTGAGVIDADYRGIVFVLLFNLSDQDFTVEEGDRVAQLVLERIITPDVLEVEDLDATARGEGGFGSTGGHKALIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>W4KET7</accession>
    <name>W4KET7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_311972</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544033.1">
        <property type="nucleotide sequence ID" value="XM_009545738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KET7"/>
    <dbReference type="STRING" id="747525.W4KET7"/>
    <dbReference type="GeneID" id="20669915"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_311972"/>
    <dbReference type="eggNOG" id="ENOG502QSY2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007406_0_0_1"/>
    <dbReference type="InParanoid" id="W4KET7"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="662"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="692"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="713"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="773"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW84352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="976" mass="107973" checksum="DF9C627289C47B2C" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFB8</accession>
    <name>W4KFB8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_241446</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
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        <property type="protein sequence ID" value="ETW84005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009545431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFB8"/>
    <dbReference type="FunCoup" id="W4KFB8">
        <property type="interactions" value="24"/>
    </dbReference>
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    <dbReference type="GeneID" id="20668891"/>
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    <dbReference type="eggNOG" id="KOG1204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_11_1"/>
    <dbReference type="InParanoid" id="W4KFB8"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
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    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF8">
        <property type="entry name" value="BENZIL REDUCTASE ((S)-BENZOIN FORMING) IRC24"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
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        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="2"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW84005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="257" mass="26767" checksum="01215CA6AAB0CF08" modified="2014-03-19" version="1" fragment="single">RPVVVVTGASRGLGLAVTSALLKQLNATVVAVSRTRTPELTQLSDAHADSLKLVECSVADEPAFAKAISDVQKTHGSIDGLVLNAGTLHPLGRVDAPSSTLDAWKSHFDVNFFSLVTALKAALPALRASRFGGKVVFVSSGAAAGGVPGWGPYNASKAAMNSLTRGTDRTLAQEEPDIVSVAVRPGKVDTEMQATLREQGGAHMRAADHESFVREHAEGRLVRPEDAGHVIAALALGAHPGLSGAFVSWDSAECSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4KG91</accession>
    <name>W4KG91_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_48060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543229.1">
        <property type="nucleotide sequence ID" value="XM_009544934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KG91"/>
    <dbReference type="GeneID" id="20677924"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_48060"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_0_3_1"/>
    <dbReference type="InParanoid" id="W4KG91"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF6">
        <property type="entry name" value="GABA-SPECIFIC PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW84091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="530" mass="56429" checksum="A11E81E0CDB42916" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGG5</accession>
    <name>W4KGG5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWR1-complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_312828</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SWC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543863.1">
        <property type="nucleotide sequence ID" value="XM_009545568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGG5"/>
    <dbReference type="FunCoup" id="W4KGG5">
        <property type="interactions" value="602"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KGG5"/>
    <dbReference type="GeneID" id="20669983"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_312828"/>
    <dbReference type="eggNOG" id="KOG2656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018539_4_1_1"/>
    <dbReference type="InParanoid" id="W4KGG5"/>
    <dbReference type="OrthoDB" id="19740at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000087">
        <property type="entry name" value="DNA methyltransferase 1-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032563">
        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027109">
        <property type="entry name" value="Swc4/Dmap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855:SF10">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16282">
        <property type="entry name" value="SANT_DAMP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="130"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="275"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="421"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW84161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="487" mass="53973" checksum="06B8AC5FB95B572A" modified="2014-03-19" version="1">MAGASAADVRSILQLPASSHAGQSQSQKKTTSKKPEGISRELYSLIGPTPSTLAAQLSKPRLKQKPNLGGGGKVKWELRPFKNGARGDGLQLKHWVKANSDPEAEYAFAKYNVQNNWYIYSQDEYERHLEDPDWSKEETDYLFDLVREYDLRFHIIADRYEFPRSMEDIKDRYFGVCRKLIRSRPWPGDEASRAQLLSSFQFDKDREVTRKEYLASLENRTPEQIAEEEAMYIELKRLEQTERAFKKERDELLRTLLGVESGLADLNVEDDSHAAITDPRKKKKAGVAEAESPATPTAAVAQPAPRRAQSAKSIAYDALHCIQRIDPPPLTPATKASHAAATLRSQKIAYPKPAVSSKVNQVVTELGVPISRGVIMPTRDTLAQYEMLIEAATALVETKKIVDRVEQEIRVARARLDMRASASDGGVGGDGGGSGAQTPMDVDEELGSRSQSRGQEGGTRAQSVVSTRSGRSGRSRKQVSIQARIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHE7</accession>
    <name>W4KHE7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase active site lid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_154598</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542138.1">
        <property type="nucleotide sequence ID" value="XM_009543843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHE7"/>
    <dbReference type="FunCoup" id="W4KHE7">
        <property type="interactions" value="538"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KHE7"/>
    <dbReference type="GeneID" id="20667506"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_154598"/>
    <dbReference type="eggNOG" id="KOG3078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032354_1_0_1"/>
    <dbReference type="InParanoid" id="W4KHE7"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036193">
        <property type="entry name" value="ADK_active_lid_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57774">
        <property type="entry name" value="Microbial and mitochondrial ADK, insert 'zinc finger' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="6">
        <location>
            <begin position="156"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW85268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="246" mass="27381" checksum="C350C182B7B3610C" modified="2014-03-19" version="1">MAVSDELEYLKSLAAQLNQKISTLEAKTKAAAPSRTPASQLRTILIGPPGAGKGTQAPRIHDQFCQVNQKTKLGAEAKKIMDAGGLVSDDIMVGIIKDQLENNEACKNGFVLDGFPRTVPQAEKLDSMLFERKEKLDSVVQLEIPDELLISRITGRLIHPASGRTYHREFHPPKKAMTDDVTGEPIIQRSDDNIETLTKRLKSFHSQTTPVVQYYKNKGLWHRIDAAQSPSVVWDNLRKVFTAKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHH6</accession>
    <name>W4KHH6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_308540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542161.1">
        <property type="nucleotide sequence ID" value="XM_009543866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHH6"/>
    <dbReference type="GeneID" id="20669596"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_308540"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_22_0_1"/>
    <dbReference type="InParanoid" id="W4KHH6"/>
    <dbReference type="OrthoDB" id="3252634at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="210" mass="23160" checksum="E5E6AA2A51017E1C" modified="2014-03-19" version="1">MGCSPYFAATGTHPLLPLDIAEATYLLPPPTTALSTTDLIARRAIALQKRRSDLAHLRSSVVGARVQAAIRFEQQHLATLRDFNFHRGSLVLMRNTAIEKALNRKMRPRYLGPLLVISRNRGGAYILAELDGSVFDRPVAAFRVIPYFARRSLKLADLEALLDISQERLRAMEDSRSSDDDAEDDSADEDTDTSSVRSAEDDDAASATSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHS7</accession>
    <name>W4KHS7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_18223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543147.1">
        <property type="nucleotide sequence ID" value="XM_009544852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHS7"/>
    <dbReference type="GeneID" id="20668612"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_18223"/>
    <dbReference type="eggNOG" id="ENOG502S3G3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_32_0_1"/>
    <dbReference type="InParanoid" id="W4KHS7"/>
    <dbReference type="OrthoDB" id="128646at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW84631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="112" mass="12907" checksum="4B9292391F2FF17B" modified="2014-03-19" version="1" fragment="single">VSNRSQYAGAKATIDSACEGVIVNETWVKRHRFPTYTLNNPIRVRNVDDTINKAGLIRSALDVNLTIRDITGRTHIERVQMFISNLGKDDLILGTDWLKYHDPSIEWRRREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHY7</accession>
    <name>W4KHY7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_448552</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542318.1">
        <property type="nucleotide sequence ID" value="XM_009544023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHY7"/>
    <dbReference type="GeneID" id="20675873"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_448552"/>
    <dbReference type="HOGENOM" id="CLU_600008_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHY7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844260" evidence="3">
        <location>
            <begin position="37"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW85457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="456" mass="48380" checksum="B9AA471621633105" modified="2014-03-19" version="1">MRAHHHVAPVGMHCTSSLPAISTSIFILFLLPGRQCNTTSCESGSFVETATLRSVCGLQDEHRALLDLDSGGALVGACPNLYLVQLSSYTAVFWASRGDAPSLSRRVTNPPASSGGGHPGGMDLRPTSQTARSPALARGTGIYALRTTATRPRTFRRDRGLHTRGSLRFCACITYIRFVLRRRAMFAPLLRPLHVLSPSTLCRAALSYPRWCFSASSLPTCLPTPPPTPPLHEPAIPKSAPSQWAVSIPLRLLHHIVRLPRTLHRLYAALPSPRPSPLYLVALALTLLALLALLTLLLLLLALLLALTLAILALLALLLPPATLRALAARLWTLAPSPSSLSLSPSLRTGLGLGLKFGIRPALDAGLALGKTAALHALPGVFARAARTPAAHVLVHAPPTPPPTRVLVHVHAPAPASAQAAGTGTGTGAELTQALLGVGPPPPRARELRRSRSWFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KI09</accession>
    <name>W4KI09_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_439398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KI09"/>
    <dbReference type="STRING" id="747525.W4KI09"/>
    <dbReference type="GeneID" id="20675139"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_439398"/>
    <dbReference type="HOGENOM" id="CLU_060568_0_0_1"/>
    <dbReference type="InParanoid" id="W4KI09"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="455" mass="49292" checksum="6F216196581C656D" modified="2014-03-19" version="1">MHHLLAALRDLLSSAFPCLSPSHRAMSSPNDVLYFPKEEFIYNVTGWAGFVLFTPTPSEDRPRIASIEHCKRKRGVFHEFLIIQFEYPVLGAPPLTVPIIVERTIETSQLPKDKIRPGADLSHENGSRFSALFQSSSSSRLSLSPSSAASSSSSSLATPAFDRIIIPPNGAPVGKIDRHARRPYKTCRKLTFNKRFTDYDLAALLLALQEYAPDYALLSRQCYWYATVIYDFFRERLIGLGNEDGEEVEYNVDNLKDERGRFLTIFTIQPPEPPLGKIKSEFEKQLAALLDERAREDHPAAKWVRSQEETRAAIAKAEEEAAARERAEAAAKEEAAARERAEAAAKEEAAARERAEAAAEEEAAARVEAEAAAKEEAAARVEAEATAKAAEAAAEAAEAAATAAAAAAKAADARAAAAEAAAEAEAAARALLDDEVALLRQQLAALNHAGPSPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4KI16</accession>
    <name>W4KI16_HETIT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_457352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542343.1">
        <property type="nucleotide sequence ID" value="XM_009544048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KI16"/>
    <dbReference type="GeneID" id="20676819"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_457352"/>
    <dbReference type="eggNOG" id="ENOG502SATQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014309_0_0_1"/>
    <dbReference type="InParanoid" id="W4KI16"/>
    <dbReference type="OrthoDB" id="3230530at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="626" mass="66501" checksum="24E1457B6AAD3627" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIQ8</accession>
    <name>W4KIQ8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_458383</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544557.1">
        <property type="nucleotide sequence ID" value="XM_009546262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIQ8"/>
    <dbReference type="STRING" id="747525.W4KIQ8"/>
    <dbReference type="GeneID" id="20676907"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_458383"/>
    <dbReference type="eggNOG" id="ENOG502SJR2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011606_0_0_1"/>
    <dbReference type="InParanoid" id="W4KIQ8"/>
    <dbReference type="OrthoDB" id="312874at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="135"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="555"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="813"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW84936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="834" mass="95362" checksum="257194A0B65EF083" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIS7</accession>
    <name>W4KIS7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate aminotransferase</fullName>
            <ecNumber evidence="7">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_414741</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="7"/>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542586.1">
        <property type="nucleotide sequence ID" value="XM_009544291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIS7"/>
    <dbReference type="FunCoup" id="W4KIS7">
        <property type="interactions" value="400"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KIS7"/>
    <dbReference type="GeneID" id="20673198"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_414741"/>
    <dbReference type="eggNOG" id="KOG1412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032440_1_0_1"/>
    <dbReference type="InParanoid" id="W4KIS7"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000064">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="32"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW85758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="411" mass="45483" checksum="A2103B305752D638" modified="2014-03-19" version="1">MAAAESWDKVPLAPPDSIFKLTAAYKADTFSKKVNLGVGAYRDDNSKPWVLPVVKKASEILLRDPDLDHEYLPITGLPEFTSAAARLILGSDSPALAEGRVVSVQTISGTGANHLGALFLSRYYQFDGDKKVYLSDPTWVNHFAIFKNVGVEPLTYPYYDPQTIGLDYAGLTRALQNAAPRSVFLLHACAHNPTGVDPTEEQWKALADVVLEKKHYAFFDCAYQGFASGDLDRDAWAVRYFASRGVPMLVCQSFAKNAGLYGERVGALHIISPTGETADRVRSQLSVLQRSEISNPPSYGARVVSLILNNAELFEEWKRDIRTMAGRIIDMRKELYRLLAEELKTPGKWEHIVNQIGMFSFTGVNPEQSKALTEKAHIYLTANGRISMAGLNSGNVRYFAESLDKAVRGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJ54</accession>
    <name>W4KJ54_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_101131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541987.1">
        <property type="nucleotide sequence ID" value="XM_009543692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJ54"/>
    <dbReference type="GeneID" id="20665734"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_101131"/>
    <dbReference type="HOGENOM" id="CLU_1992914_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJ54"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="125" mass="13727" checksum="E8681FC5EEDF575E" modified="2014-03-19" version="1">MVNLSSSSKIRKKGPTAGKYMDQKDASLALALSIGEAQEDRTRQKVGKINKAQKAPKDDRKTRSAAQTKLKDATAILLARKCDAKKAKTKLRRESKRKQSRANAVDISVSNDAQSTPIRKKVSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJC1</accession>
    <name>W4KJC1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_407479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542278.1">
        <property type="nucleotide sequence ID" value="XM_009543983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJC1"/>
    <dbReference type="STRING" id="747525.W4KJC1"/>
    <dbReference type="GeneID" id="20672603"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_407479"/>
    <dbReference type="eggNOG" id="KOG3117">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1310282_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJC1"/>
    <dbReference type="OrthoDB" id="203440at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="210" mass="23615" checksum="651547AE2C9B03FB" modified="2014-03-19" version="1">MSSDQDDGDEENDSHDRDGIYRPPKLAPVPYTESSKDKRARRAPIPAALSSLAHLDPSRPFVESTSGLGATPSMQSTRAREIQRMTEFEEENMTRLVLKKKDDKRRRKDEEDIALGGTGGIVGRRRGGGLEDEFSDVLRSVGRTRMGAVGDGYEELRTKGRKQDALSRARTRGRDEVDGPGGDEQRQRKRSRFEKEVRVAKKRMSAKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKE3</accession>
    <name>W4KKE3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_309960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542627.1">
        <property type="nucleotide sequence ID" value="XM_009544332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKE3"/>
    <dbReference type="STRING" id="747525.W4KKE3"/>
    <dbReference type="GeneID" id="20669734"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_309960"/>
    <dbReference type="eggNOG" id="ENOG502SH1N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1932653_0_0_1"/>
    <dbReference type="InParanoid" id="W4KKE3"/>
    <dbReference type="OrthoDB" id="2669721at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="156" mass="17517" checksum="2821E17ED529F271" modified="2014-03-19" version="1" fragment="single">FLPGSFDHPPCNPAEKISSGYKCWEFLHYIYGLGPGLLHGILSDRCWQNFCKLAASVWIIFQLHIPYSQLLKASTLLADFVHDFKVLYVKCKVSCLHFVLQCMYALTHAPSATFQLGPLGCSSQFPMEWTMGDLGAEIKQPLNSFANLAEHALHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLP9</accession>
    <name>W4KLP9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_447335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540642.1">
        <property type="nucleotide sequence ID" value="XM_009542347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLP9"/>
    <dbReference type="STRING" id="747525.W4KLP9"/>
    <dbReference type="GeneID" id="20675761"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_447335"/>
    <dbReference type="HOGENOM" id="CLU_1461493_0_0_1"/>
    <dbReference type="InParanoid" id="W4KLP9"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF3">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW86639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="185" mass="20504" checksum="73A2E979DF3A1CBA" modified="2014-03-19" version="1">MAMQRNMDSPAVSEPSKPGQAHHWPTRPAALNAIQQPATALLLHGLFPTQVTYSGIHVYETMCKDVAARTRVLEREVQKGEHERVQGGYGKYHSESLRSRLSPRLSCPDTSSPSHWPVASRHLDSSSARTAACQAVQLRPLNWMSAAKYYGDQILECFIPDSHQLPDILINPPADIDPNIAIDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMM6</accession>
    <name>W4KMM6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_166625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541040.1">
        <property type="nucleotide sequence ID" value="XM_009542745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMM6"/>
    <dbReference type="FunCoup" id="W4KMM6">
        <property type="interactions" value="328"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KMM6"/>
    <dbReference type="GeneID" id="20668070"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_166625"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="InParanoid" id="W4KMM6"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="39"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="471"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW87098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="596" mass="65364" checksum="C95D88D5C10EE53A" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMR0</accession>
    <name>W4KMR0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ribonuclease T2-like</fullName>
            <ecNumber evidence="4">4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">Rnase_T2_1</name>
        <name evidence="20" type="ORF">HETIRDRAFT_40965</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Rnase which modulates cell survival under stress conditions. Released from the vacuole to the cytoplasm during stress to promote tRNA and rRNA cleavage and to activate separately a downstream pathway that promotes cell death. Involved in cell size, vacuolar morphology and growth at high temperatures and high salt concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the RNase T2 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.19" evidence="4"/>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540320.1">
        <property type="nucleotide sequence ID" value="XM_009542025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMR0"/>
    <dbReference type="GeneID" id="20672792"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_40965"/>
    <dbReference type="eggNOG" id="KOG1642">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037966_0_1_1"/>
    <dbReference type="InParanoid" id="W4KMR0"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.730.10:FF:000004">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018188">
        <property type="entry name" value="RNase_T2_His_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057328">
        <property type="entry name" value="RNaseT2L_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25488">
        <property type="entry name" value="RNaseT2L_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00530">
        <property type="entry name" value="RNASE_T2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844341" description="Ribonuclease T2-like" evidence="18">
        <location>
            <begin position="20"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="RNase T2-like C-terminal" evidence="19">
        <location>
            <begin position="288"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR633697-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF25488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ETW87133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="407" mass="42025" checksum="34A90F496C7AAC36" modified="2014-03-19" version="1">MFSLSLLWVALSGSAAVSASTINTTFARPLDHLFKRLSTSCGTSGQTSCLNTTAQSNLCCFEAPGGLLLQTQFWDTNPSTGPSNSWTIHGLWPDNCDGTFKSSCDSSRAYTGISSLLSSQGASDTLSFMDDYWVDINGDNEQFWEHEWSKHGTCMSTLHTSCLPSGSAKGAEAVAFFQTVVKLFKSLPTYDWLAAEGITPSSSQTFTLSQITSALKSQSGVTPALDCDGKNLNQISWYFHLKGSVIDGKFVAIDAPEAGSCASTGLKYPPKSGTPVSSVSTSNAPGDLPSKATISVLTSSGAVGGLLSAGTWSVQTPGTYTISGTGSSFTLTSSKGKCAVQSSSLICGSSVSTASTFSAVTSGSDLLVAFSGSTAFSSSAVPSGAVQQTLVTGNGQSQHVTLALVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMS2</accession>
    <name>W4KMS2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_41809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540347.1">
        <property type="nucleotide sequence ID" value="XM_009542052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMS2"/>
    <dbReference type="FunCoup" id="W4KMS2">
        <property type="interactions" value="294"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KMS2"/>
    <dbReference type="GeneID" id="20673447"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_41809"/>
    <dbReference type="eggNOG" id="KOG3425">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120161_2_1_1"/>
    <dbReference type="InParanoid" id="W4KMS2"/>
    <dbReference type="OrthoDB" id="78947at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045108">
        <property type="entry name" value="TXNDC17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010357">
        <property type="entry name" value="TXNDC17_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452">
        <property type="entry name" value="42-9-9 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06110">
        <property type="entry name" value="TXD17-like_Trx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="19"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW87117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="116" mass="13187" checksum="F9A20AC23B319914" modified="2014-03-19" version="1">MPLYTASSPLEFSSWKDVQEKFVIFYASRDREGKMWCPDCRDVEDTVERTFAGADAPPALIIYVGQKPEWKAASNHFRDAPWYIEAIPTIVRVKDATEDARLVEGDIVSQLASFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMV4</accession>
    <name>W4KMV4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_456860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the taxilin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541083.1">
        <property type="nucleotide sequence ID" value="XM_009542788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMV4"/>
    <dbReference type="STRING" id="747525.W4KMV4"/>
    <dbReference type="GeneID" id="20676780"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_456860"/>
    <dbReference type="eggNOG" id="KOG1850">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043419_1_0_1"/>
    <dbReference type="InParanoid" id="W4KMV4"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01763">
        <property type="entry name" value="Ubl_SUMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026183">
        <property type="entry name" value="Taxilin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127:SF13">
        <property type="entry name" value="GH01188P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127">
        <property type="entry name" value="TAXILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09728">
        <property type="entry name" value="Taxilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="266"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="413"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW87147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="55871" checksum="F4CEFFC84FB42951" modified="2014-03-19" version="1">MSAVMTNSQTATIPRTAKPPPSGPAPPAPAAVPPSTAHPPPANRAHPPPHNHPPAVNGMHSTQKGKKKNEPAPVDPATMYESLKNRIAALEEEEVLEEEEERRFAEEAQKSVVGMEERAIHAKYIELFAELKRLERDHQKEKQKLIKDKDAAKGQLTKANQTKVKMENLARELQKDNKRLREDGKRLAHSVEEAQDEIIQMKKDMTKRAEKAKLQDTKFRDMPDIVVKVICRYREELFFRISRKTKLSKLFNAWTERMEASSIVKKSDGFNGGNLSNGSGKSDASAHSTSSVHVPSTNTQFVFTHSGRAVDAEQTPEEAGIEDGDEILAVELMDLTEGPGTEFLDEGEPRRQKLRKHWTDNPKEAVRTLEEIFDGVIRERLKEVLRQYELRERHFECVIRSKELEVLLSRARAAEQKQLAEGEKVRADKLEDESQHLRKELEDAQRGQTMLVDRLITCCKEPNAERTQRLFASLRDELEKRGRGTKSIEGAVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4KN28</accession>
    <name>W4KN28_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Polysaccharide lyase family 8 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_431647</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide lyase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541172.1">
        <property type="nucleotide sequence ID" value="XM_009542877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KN28"/>
    <dbReference type="GeneID" id="20674553"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_431647"/>
    <dbReference type="eggNOG" id="ENOG502S9ZG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004172_3_0_1"/>
    <dbReference type="InParanoid" id="W4KN28"/>
    <dbReference type="OrthoDB" id="5980780at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016837">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on polysaccharides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.10">
        <property type="entry name" value="Polysaccharide lyase family 8-like, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038970">
        <property type="entry name" value="Lyase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011071">
        <property type="entry name" value="Lyase_8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012970">
        <property type="entry name" value="Lyase_8_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004103">
        <property type="entry name" value="Lyase_8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003159">
        <property type="entry name" value="Lyase_8_central_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38481">
        <property type="entry name" value="HYALURONATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38481:SF1">
        <property type="entry name" value="HYALURONATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02278">
        <property type="entry name" value="Lyase_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02884">
        <property type="entry name" value="Lyase_8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08124">
        <property type="entry name" value="Lyase_8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49863">
        <property type="entry name" value="Hyaluronate lyase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Polysaccharide lyase 8 N-terminal alpha-helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide lyase family 8 central" evidence="4">
        <location>
            <begin position="429"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide lyase family 8 C-terminal" evidence="5">
        <location>
            <begin position="630"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW87248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="735" mass="80217" checksum="A2390ABA0A5B069D" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KN41</accession>
    <name>W4KN41_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_166801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541186.1">
        <property type="nucleotide sequence ID" value="XM_009542891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KN41"/>
    <dbReference type="GeneID" id="20668086"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_166801"/>
    <dbReference type="HOGENOM" id="CLU_427619_0_0_1"/>
    <dbReference type="InParanoid" id="W4KN41"/>
    <dbReference type="OrthoDB" id="3270281at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="640" mass="66954" checksum="61E64588DA4FB698" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KN95</accession>
    <name>W4KN95_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_308461</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="4">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541203.1">
        <property type="nucleotide sequence ID" value="XM_009542908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KN95"/>
    <dbReference type="FunCoup" id="W4KN95">
        <property type="interactions" value="566"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KN95"/>
    <dbReference type="GeneID" id="20669589"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_308461"/>
    <dbReference type="eggNOG" id="KOG3373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097408_2_2_1"/>
    <dbReference type="InParanoid" id="W4KN95"/>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="37"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW87282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="141" mass="15379" checksum="2AF5D9C09E81E591" modified="2014-03-19" version="1">MVSRVRYELRSCYVSLAIAKKYTSDHEAVIFDDETNVGTVTITDYAQTSLGDVVFVELPQEGSEVEQGAMIGAVESVKAASDIFSPISGKVVSINEELAGQPSLLNKSPEDKGWLCKIELSNPSELDELMTAEQYKAHCES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNK4</accession>
    <name>W4KNK4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_431289</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540639.1">
        <property type="nucleotide sequence ID" value="XM_009542344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNK4"/>
    <dbReference type="GeneID" id="20674524"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_431289"/>
    <dbReference type="eggNOG" id="ENOG502SG9K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_787793_0_0_1"/>
    <dbReference type="InParanoid" id="W4KNK4"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050460">
        <property type="entry name" value="Distal-less_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24327:SF41">
        <property type="entry name" value="BRAIN-SPECIFIC HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24327">
        <property type="entry name" value="HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="32"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="34"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="221"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW86636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="290" mass="32251" checksum="3A978503F6686FB2" modified="2014-03-19" version="1">MAPVRHDISRTSSIASMSSDDIPNIDVEGLCGSAKRTRKRFTNLQLMMLEQLFHRTSHPTRDEREALAAEVGMESKSVTIWFQNRRQTERRATLHNATSSANAARVPVPTSSVPFPIQTPSTTRRRVSSIPSSSSSYFAPETPFNRRPSLDHVASRSELRTAPPRTPSRRHDPSKSLWDNMPSSPLAPPSPPAREYVEFGKNKRTRTLEWACAAARLADKEKGRAKMSKVEDGDETEEEDPQEAITPMGSLTGIDPSWEKKKESQNQDATVNDDVMTAALVLCGLGRRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNM3</accession>
    <name>W4KNM3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_424231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    </evidence>
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                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Yakovlev I."/>
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        </citation>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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                <person name="Asiegbu F."/>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
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                <person name="Gonthier P."/>
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                <person name="Hansson D."/>
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                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lunden K."/>
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                <person name="Raffaello T."/>
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                <person name="Velez H."/>
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                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="1">Belongs to the ATG14 family.</text>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF5">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPS0</accession>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541003.1">
        <property type="nucleotide sequence ID" value="XM_009542708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPS0"/>
    <dbReference type="STRING" id="747525.W4KPS0"/>
    <dbReference type="GeneID" id="20669588"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_308457"/>
    <dbReference type="eggNOG" id="KOG2009">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029054_0_0_1"/>
    <dbReference type="InParanoid" id="W4KPS0"/>
    <dbReference type="OrthoDB" id="272624at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001156">
        <property type="term" value="F:TFIIIC-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929:SF0">
        <property type="entry name" value="TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="161"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW87056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="318" mass="34910" checksum="71D05552CA078D0C" modified="2014-03-19" version="1">MAALCEESSQGRASSKAAQIFDNHATWKRVNRERRARMRALMEAKKYGRDDEDDEGEGLSATPIADGPSNIPPNAVPSGSTSNDAEVEAEAGEGEDSQGFDYSQSLNTSRFNVQVRIGPNGETIVDEESLFVDRADDQDTANYTHIEESDATKFVNSASYAKKFRGSRWSAEETELFYDALSQFGENYELISYILPGRDRKSCKNKFKAEDKKNPNRITYCLNNRIPYDMKTLSRMTGKDFSGPTPVIIAPARPNLAQLSLHTAASQAGANNPTDQDNAPSRPSSATGSRAHAKKHGRKKDDGVEVLGAIDSVDWDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4KRL4</accession>
    <name>W4KRL4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_42374</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the p23/wos2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540362.1">
        <property type="nucleotide sequence ID" value="XM_009542067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KRL4"/>
    <dbReference type="FunCoup" id="W4KRL4">
        <property type="interactions" value="766"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KRL4"/>
    <dbReference type="GeneID" id="20673940"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_42374"/>
    <dbReference type="eggNOG" id="KOG3158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078883_0_0_1"/>
    <dbReference type="InParanoid" id="W4KRL4"/>
    <dbReference type="OrthoDB" id="1564555at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06465">
        <property type="entry name" value="p23_hB-ind1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000013">
        <property type="entry name" value="Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF1">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="2"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW87711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="222" mass="23941" checksum="1447BDAA073881EE" modified="2014-03-19" version="1">MAQHPEILWAQRSSEIDEEKNILFVTINLPDVIESSLQFDLKPTGITFKARVGDASKGIQEKEYAFDLEFFKEIDPEKSVKRVSSRALNLTLRKAEKAAEYWPRLTKDKTKKAFIKTDFSRWVDEDEQDGEPAAPQEEPEGMPGFPGMDMGGMGGMGGMGGMGGMGDMGGMGGMGGMDIQKMLAEMGQGGAGPSSGEIGDAEESDSDDDGPPPLEDAEPAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMI6</accession>
    <name>W4JMI6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_437297</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GCN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553230.1">
        <property type="nucleotide sequence ID" value="XM_009554935.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="W4JMI6">
        <property type="interactions" value="835"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JMI6"/>
    <dbReference type="GeneID" id="20674945"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_437297"/>
    <dbReference type="eggNOG" id="KOG1242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000504_2_0_1"/>
    <dbReference type="InParanoid" id="W4JMI6"/>
    <dbReference type="OrthoDB" id="5148094at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022716">
        <property type="entry name" value="Gcn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056810">
        <property type="entry name" value="GNC1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056809">
        <property type="entry name" value="HEAT_GCN1_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF7">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Duplessis S."/>
                <person name="Durling M."/>
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                <person name="Hansson D."/>
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                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
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                <person name="Yakovlev I."/>
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                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
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    </evidence>
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            <dbReference type="EMBL" id="ETW74973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="443" mass="51120" checksum="C3F950A23892E99A" modified="2014-03-19" version="1">MRLLLRLDALYKPWRASPAGRLVFPLPITTYFQSRYSKSKLSDMSRNEEKGHRYKLWKKLQVDPAPSTRAKMFDKASEYKFLYTSEEKGSNVAPTVAVIPLKKVYAMEKMRRNNSKKFLLLFAEMIDMMAELLPLEDIHDLDFDLGEGLPILRGRMQSLIDTIGQDIENCYNLCDRYTSETIVRKVFKASDWDDALTACAQLFVRHRRDIMQALAAHAAHGVDELQKGQQDLQRRHAIHYVDTMRDILLKCFEKLRTKSERDLTQLVVRFGGSAKILTNDKALEEVYLKSQRQNKATEQKDLSSRVQAKGKLDFQELKKELSRSVEDSIKENQERFRSKMRLMDQNITDTVAQTGDRIIKTLTEDTWDLIKDPDQRASIRSAHFFLALRDYYQINSSTLERTASGLESIPETSERTSMDPNPAAAVPRKPVRFLTLPTQNPTA</sequence>
</entry>
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                <person name="Asiegbu F."/>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
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                <person name="Velez H."/>
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                <person name="Martin F."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004843784" evidence="1">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="54" mass="5600" checksum="DC9B6FC92A744D58" modified="2014-03-19" version="1">MILGIASSFTLILLVVVAGHFRPSGVNSTLHFSDVVGAASTHQLIGTHTLLVLS</sequence>
</entry>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Asiegbu F."/>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
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                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
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                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009554565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPE7"/>
    <dbReference type="GeneID" id="20673874"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_423133"/>
    <dbReference type="HOGENOM" id="CLU_2961068_0_0_1"/>
    <dbReference type="InParanoid" id="W4JPE7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="59" mass="6479" checksum="0EED5A799CAB3A09" modified="2014-03-19" version="1">MSFVRKTPTHPTGGYRSHEENISRAQSATLPKQGIEVEACCFVSAAGNERLRSQEAEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPX2</accession>
    <name>W4JPX2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Esterase/lipase/thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_164870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553389.1">
        <property type="nucleotide sequence ID" value="XM_009555094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPX2"/>
    <dbReference type="FunCoup" id="W4JPX2">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JPX2"/>
    <dbReference type="GeneID" id="20667944"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_164870"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_6_3_1"/>
    <dbReference type="InParanoid" id="W4JPX2"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="95"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW74926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="348" mass="38718" checksum="0534A8C2F9649F55" modified="2014-03-19" version="1">MSRHSQLSIPNAEFAALIAGQSSQSLPEDLIAVREVFKTAYAKGMEEHFGSTLPPASEYSVQDYNIPVGDPSDEILIRCLVPSFVNKPRKTFPLLVWYHGGGWVAGYAAMDDYLLRHICVEMQISVMNVDYRLAPEFPFPTGVNDSYAALKWAVCNTALLSVDLSKGFIVSGLSAGGNIAAAIAVRARDDPFFKSQPLTGQILHSPAVVHMDAYPDKYKDELKSAEEFAEAEVLRGSSFHWFYGLLRAPAMDPDISPLLATTHVGLPPLCMHVSGMDPLRDENFLYTEVLKEQGVRTKLFVAMVKISWPATRFRVFLSNYVHFWTILERFQGVHRLAFAHVYPSRASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPY8</accession>
    <name>W4JPY8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_164856</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553401.1">
        <property type="nucleotide sequence ID" value="XM_009555106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPY8"/>
    <dbReference type="GeneID" id="20667942"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_164856"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_6_1"/>
    <dbReference type="InParanoid" id="W4JPY8"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF6">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW74941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="276" mass="30407" checksum="1B58964BBD802579" modified="2014-03-19" version="1" fragment="single">ILNRITRPSLYIGTCVIVWGLTSTLIGAAFYPGAIYLLSRWYTRYELAFRSAILYGGLLISNAFGSLIAAGILSGISGMDGRLGIRAWRWSVLLHSSVCALIIRVVFNRVLRVILHRVQGAVTMLLGFWTIYLLSDYPNNGRRLSPAERRLAQVRLSQDAGEADEDTTHDSAWGGFVSAIKDPKVCIISVMNCSQLLGLSFTNFFPTPPWIFATIVCCLNAWHADRTGERFFHIAGSWWCAILGYIIGLNTISIGGRYVALFLMAAGESSFALTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQ87</accession>
    <name>W4JQ87_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_108155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552681.1">
        <property type="nucleotide sequence ID" value="XM_009554386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQ87"/>
    <dbReference type="GeneID" id="20666318"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_108155"/>
    <dbReference type="HOGENOM" id="CLU_443474_0_0_1"/>
    <dbReference type="InParanoid" id="W4JQ87"/>
    <dbReference type="OrthoDB" id="3261131at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW75245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="616" mass="67665" checksum="9C2EBE442A279A76" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQP3</accession>
    <name>W4JQP3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_422434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552035.1">
        <property type="nucleotide sequence ID" value="XM_009553740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQP3"/>
    <dbReference type="GeneID" id="20673813"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_422434"/>
    <dbReference type="eggNOG" id="ENOG502SVBW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042818_1_0_1"/>
    <dbReference type="InParanoid" id="W4JQP3"/>
    <dbReference type="OrthoDB" id="2722301at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="226" mass="25608" checksum="124BDFCDE7EFCC9F" modified="2014-03-19" version="1">MPRWGPLRGDRVFPTMADCLNFIQGMLKGLVSLHLHCIAHRDLQASNAVMDHYQSETVVPIKSWQSTRDLFGGQDSVIYNIIDFDYAFIIPPYCLYHEAEESLTTSIHYPRDTRQGELEYNPFAYDVGALGVMFCNMFQDLILHAPMMTPLLDMMVTSDVSRRLAAVEALHFFQHGLLPSPSDEQLAMAPPPLSPYRVVTVEDDRWAGLPSDFVAKWKEHCTPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQX5</accession>
    <name>W4JQX5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_456087</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552901.1">
        <property type="nucleotide sequence ID" value="XM_009554606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQX5"/>
    <dbReference type="GeneID" id="20676693"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_456087"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004645_1_0_1"/>
    <dbReference type="InParanoid" id="W4JQX5"/>
    <dbReference type="OrthoDB" id="446925at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="286"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW75490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="503" mass="57186" checksum="CB33DC5748D4A650" modified="2014-03-19" version="1">MRKDFPFVFGPDQIAAQDDLWSALLESPALWLIDYGLAANVILTIDTSQIAVGFHLCQCALNNSRVWYYAQFSSITLHDRKSQFSQPKLELYGLFCALQSLKMYLIGVRNLIVEVDARYIKGMLTNLDLEPSASINCFLHQINNMFPTTNSTSTTAIFTSSLIGDLPTDADSDDEGPTIDYSDIPRLQKALEVEKCLWLFFIAADKLWRKDLHGRHKIVAAPSSRITILTATHDNVAYKGFYAMTVLVAERFWWLHIRQDISWFVWTCHLCQICQTRNVLIPSTIATPAPLFAKMYMDTMHMLTASGFKYLIQGCCLVSHYPEFRMLRCETSSALAGWIFKDILCRWETLVKIISNNGPAFVKALDQLAKKYHIRHIRISGYNSRANGIAERPHFDVQQALFKAVDGDQAKWNRAAHFVFWADRIIVRCRMGCSPYFAATRTHPLLPLDIAEATYLLPPPTTTLSTTDLIARWAIALQKHRSDLAHLRSSVVDAYVQAAIRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQY0</accession>
    <name>W4JQY0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_162716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552183.1">
        <property type="nucleotide sequence ID" value="XM_009553888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQY0"/>
    <dbReference type="GeneID" id="20667787"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_162716"/>
    <dbReference type="HOGENOM" id="CLU_2441136_0_0_1"/>
    <dbReference type="InParanoid" id="W4JQY0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW75948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="90" mass="9070" checksum="E71ED64BFFB3326C" modified="2014-03-19" version="1">MSEPVAHDVQSNSSQPSSSLSGIPPGTLSQTASASEETSSSLLPSSCSNVSVIDDPALASLPHSGGIDLFVSFWSYCVVLVATMATAVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRC6</accession>
    <name>W4JRC6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cep5 cellulose medium expressed protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cep5</name>
        <name evidence="1" type="ORF">HETIRDRAFT_106688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552313.1">
        <property type="nucleotide sequence ID" value="XM_009554018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRC6"/>
    <dbReference type="STRING" id="747525.W4JRC6"/>
    <dbReference type="GeneID" id="20666183"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_106688"/>
    <dbReference type="HOGENOM" id="CLU_057554_1_0_1"/>
    <dbReference type="InParanoid" id="W4JRC6"/>
    <dbReference type="OrthoDB" id="3250044at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="273" mass="30224" checksum="FB84B830E1DC3026" modified="2014-03-19" version="1">MAESIVLALKNDSIPAWLPSPENIVLECLKHGRGPSNIPIHPPDGSDAAIVKWGPAVGMSEARTQDFLAKQVNEDNNSAVRVPVVYLAFRHNNVGYIAMQHVGDRDFTRDDFPKIALAVKHLQQIPSPTSAPGPINGGPIMPSVDLLEEHINALLAYKRWPWRVDFAEKTGIPLSLCIDDLHWGNFRIDSSGLIYSIDHARTNFLPLAFRHLSLAQGEELAMMLEEPLEDTEATQLWPMRLASGDFNMTSSDSSKALPDSLRALKGDHYSLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRG3</accession>
    <name>W4JRG3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">ATP-citrate synthase</fullName>
            <ecNumber evidence="23">2.3.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">ATP-citrate (pro-S-)-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Citrate cleavage enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">HETIRDRAFT_422651</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22">Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism.</text>
    </comment>
    <comment type="function">
        <text evidence="19">Catalyzes the formation of cytosolic acetyl-CoA, which is mainly used for the biosynthesis of fatty acids and sterols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 23">
            <text>oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="21">Composed of two subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 23">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 23">In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="23"/>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552277.1">
        <property type="nucleotide sequence ID" value="XM_009553982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRG3"/>
    <dbReference type="FunCoup" id="W4JRG3">
        <property type="interactions" value="539"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JRG3"/>
    <dbReference type="GeneID" id="20673832"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_422651"/>
    <dbReference type="eggNOG" id="KOG1254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006587_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRG3"/>
    <dbReference type="OrthoDB" id="3261737at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06100">
        <property type="entry name" value="CCL_ACL-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000004">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000005">
        <property type="entry name" value="ATP-citrate synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.110:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000024">
        <property type="entry name" value="Probable ATP-citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014608">
        <property type="entry name" value="ATP-citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032263">
        <property type="entry name" value="Citrate-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056749">
        <property type="entry name" value="Citrate_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118:SF42">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16114">
        <property type="entry name" value="Citrate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24948">
        <property type="entry name" value="Citrate_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036511">
        <property type="entry name" value="ATP_citrt_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 23" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8 23" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="17 23" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 23" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 23" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="CoA-binding" evidence="26">
        <location>
            <begin position="535"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="474"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="24">
        <location>
            <position position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047593"/>
        </source>
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                <person name="Lin Y.C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Fossdal C.G."/>
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                <person name="Lind M."/>
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                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551250.1">
        <property type="nucleotide sequence ID" value="XM_009552955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JS19"/>
    <dbReference type="STRING" id="747525.W4JS19"/>
    <dbReference type="GeneID" id="20671404"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_328280"/>
    <dbReference type="eggNOG" id="ENOG502S6X4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047639_6_2_1"/>
    <dbReference type="InParanoid" id="W4JS19"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF27">
        <property type="entry name" value="RLPA-LIKE PROTEIN DOUBLE-PSI BETA-BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844928" evidence="2">
        <location>
            <begin position="21"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="RlpA-like protein double-psi beta-barrel" evidence="3">
        <location>
            <begin position="76"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW76328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="152" mass="16210" checksum="8210E9093FFB8500" modified="2014-03-19" version="1">MVAFTPLIFLLSALAASVSAAPTPTSRAASKSGEGQQFFLSGSDELHPLAVFLGTFFEPGLGACGIHNSSKDMIVAVSQQLFDNFPGAGKNPNKNPICNKSITAHFKNKSVKVKVTDRCTGCKLNDLDFTPSAFSKLADQSLGRIPITWEFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSP0</accession>
    <name>W4JSP0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_328859</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551374.1">
        <property type="nucleotide sequence ID" value="XM_009553079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSP0"/>
    <dbReference type="FunCoup" id="W4JSP0">
        <property type="interactions" value="263"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JSP0"/>
    <dbReference type="GeneID" id="20671449"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_328859"/>
    <dbReference type="eggNOG" id="KOG3087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063953_1_1_1"/>
    <dbReference type="InParanoid" id="W4JSP0"/>
    <dbReference type="OrthoDB" id="3399at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000323">
        <property type="entry name" value="TP53-regulating kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06293">
        <property type="entry name" value="Kdo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW76474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="203" mass="22417" checksum="0A258CE9722AE767" modified="2014-03-19" version="1" fragment="single">LLKHRFHKQYRHPTLDGSLTRARVAGEARALLKCMRSGVNVPGIRMVDAVNGLLGIEWIEGKSVRFLLGGGAEGEAEADDTLMVMIGEEIAKMHLADVIHGDLTTSNMMLRHPASFTAPSPDRPRTQLVLIDFGLAYTSTLVEDKAVDLYVLERAFASTHPASEPLFASVLTAYQKRMGKDWPAVGRRLDEVRLRGRKRSLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4JT53</accession>
    <name>W4JT53_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_327880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551596.1">
        <property type="nucleotide sequence ID" value="XM_009553301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JT53"/>
    <dbReference type="STRING" id="747525.W4JT53"/>
    <dbReference type="GeneID" id="20671368"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_327880"/>
    <dbReference type="HOGENOM" id="CLU_1199957_0_0_1"/>
    <dbReference type="InParanoid" id="W4JT53"/>
    <dbReference type="OrthoDB" id="4851849at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="231" mass="26872" checksum="083D797AAFB7F80E" modified="2014-03-19" version="1">MRRRPMLKFQRFGKLSQDYLNVERYMEKIVSLHNSINALFRIAQNKKFKQWFSTPLHVTLVQGKSQTFLVDMNNPDLLQQCFGGRQAVAQAHDRWQSKVVAQVHSELTSTSRHQSNKFNSIVRVHCECAMVVFLEQRLNETLIHFIGVSKLCCHGCYVFIRAYNDQNVRIRYEFAGTHDLHNKVKREVLRILRNDFRAAWTQPRKGRSYSDSTAASFVPIDEGEVDQGGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4JT68</accession>
    <name>W4JT68_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_327953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551630.1">
        <property type="nucleotide sequence ID" value="XM_009553335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JT68"/>
    <dbReference type="GeneID" id="20671377"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_327953"/>
    <dbReference type="HOGENOM" id="CLU_2886077_0_0_1"/>
    <dbReference type="InParanoid" id="W4JT68"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="63" mass="7074" checksum="3FF6D55DBB25330B" modified="2014-03-19" version="1">MRKPRRAQAQNTRLIVMDFLIGPSSIGWHSWRAGPVTFVSLEPPSSFDHSSVRHLLSPCSISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4JU13</accession>
    <name>W4JU13_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase 9.5 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_52869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551158.1">
        <property type="nucleotide sequence ID" value="XM_009552863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JU13"/>
    <dbReference type="STRING" id="747525.W4JU13"/>
    <dbReference type="GeneID" id="20678232"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_52869"/>
    <dbReference type="eggNOG" id="ENOG502S74C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166990_2_0_1"/>
    <dbReference type="InParanoid" id="W4JU13"/>
    <dbReference type="OrthoDB" id="2093409at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22903">
        <property type="entry name" value="NI9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039961">
        <property type="entry name" value="Nuo9.5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8971" checksum="C5C837517A4E1A4A" modified="2014-03-19" version="1">MSTFIAPLRRTYRYLQRQAHEAPVIFYSVVIGSVGPVLAFSVPTIRQSYGWRPAEPIPITYPIPNRPRRPVQGYEDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUF5</accession>
    <name>W4JUF5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_436152</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550645.1">
        <property type="nucleotide sequence ID" value="XM_009552350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUF5"/>
    <dbReference type="STRING" id="747525.W4JUF5"/>
    <dbReference type="GeneID" id="20674870"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_436152"/>
    <dbReference type="eggNOG" id="KOG1838">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_365256_0_0_1"/>
    <dbReference type="InParanoid" id="W4JUF5"/>
    <dbReference type="OrthoDB" id="5954035at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000952">
        <property type="entry name" value="AB_hydrolase_4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01133">
        <property type="entry name" value="UPF0017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="373"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="532"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="738"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW77099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="764" mass="79503" checksum="4FEBC8B3E43309A8" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUN5</accession>
    <name>W4JUN5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 monooxygenase 92</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cpm92</name>
        <name evidence="11" type="ORF">HETIRDRAFT_174105</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550789.1">
        <property type="nucleotide sequence ID" value="XM_009552494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUN5"/>
    <dbReference type="STRING" id="747525.W4JUN5"/>
    <dbReference type="GeneID" id="20668488"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_174105"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_3_1"/>
    <dbReference type="InParanoid" id="W4JUN5"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW77257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="515" mass="58112" checksum="CBC87D3ED3EC1815" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUV9</accession>
    <name>W4JUV9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_454666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550857.1">
        <property type="nucleotide sequence ID" value="XM_009552562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUV9"/>
    <dbReference type="STRING" id="747525.W4JUV9"/>
    <dbReference type="GeneID" id="20676541"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_454666"/>
    <dbReference type="HOGENOM" id="CLU_2794254_0_0_1"/>
    <dbReference type="InParanoid" id="W4JUV9"/>
    <dbReference type="OrthoDB" id="3259063at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="68" mass="7480" checksum="CA77767BCEE843EE" modified="2014-03-19" version="1">MAVIPKMPIMAPPTSNGKPPPNFPNTKGEFEHLTRERYEAILKAYGQSVKGDTEAKKQALRVFIGLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4JV17</accession>
    <name>W4JV17_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_52748</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550510.1">
        <property type="nucleotide sequence ID" value="XM_009552215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JV17"/>
    <dbReference type="GeneID" id="20678226"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_52748"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_10_0_1"/>
    <dbReference type="InParanoid" id="W4JV17"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DIOX_N"/>
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    </dbReference>
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        <property type="entry name" value="IPNSYNTHASE"/>
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        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="3">
        <location>
            <begin position="42"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="2">
        <location>
            <begin position="223"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW77304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="42658" checksum="A37D0FF5C29687EF" modified="2014-03-19" version="1">MSTTTTVSETLPSSSTTKNVIPKWKAPPPTTETELEWADILTVDLSLYDTKRDELVKTVETALQRDGFFYVVGHGIPQESVHKQFSIGQFAFDGVSKEEKKAHRAPIAEEGSFIGYKLQNYWEIRDGVRDRIEHYNFYLNQIDPISRHPKPLQPYVDEVKAFIAESRQKVLRRVLSLIDAVLGLEDGYLWQLHEDPQGRKGNDLFRYMIYDPLTSAEASKTNNVMLNGHTDFNSISTLVSQPVTALQILLPDGHWRYVRHREGALVINIGDQLSFMSGGLLKGTIHRVVLPPKDQLKYRRLGVFHFAHFISGIPLDPLPSKKVQTEGRKIFEGKVPTTDEWESARVKTYGTAQLIKGEQYDTEYIAGLQVRHWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWM7</accession>
    <name>W4JWM7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HETIRDRAFT_388021</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009551674.1"/>
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    </dbReference>
    <dbReference type="STRING" id="747525.W4JWM7"/>
    <dbReference type="GeneID" id="20672342"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_388021"/>
    <dbReference type="eggNOG" id="KOG0292">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007565_1_0_1"/>
    <dbReference type="InParanoid" id="W4JWM7"/>
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    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="C:Golgi membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
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    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_CS"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TPR_COPA_B"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_1"/>
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    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="5 13" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="8"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="94"/>
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        </location>
    </feature>
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            <begin position="136"/>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="197"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="241"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="14">
        <location>
            <begin position="335"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="16">
        <location>
            <begin position="608"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer alpha subunit C-terminal" evidence="15">
        <location>
            <begin position="854"/>
            <end position="1204"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022574"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR003354"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF06957"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETW77957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1208" mass="134493" checksum="46253ACFD288EA4E" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXB3</accession>
    <name>W4JXB3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_39172</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549638.1">
        <property type="nucleotide sequence ID" value="XM_009551343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXB3"/>
    <dbReference type="STRING" id="747525.W4JXB3"/>
    <dbReference type="GeneID" id="20672485"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_39172"/>
    <dbReference type="eggNOG" id="KOG4178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_7_4_1"/>
    <dbReference type="InParanoid" id="W4JXB3"/>
    <dbReference type="OrthoDB" id="6431331at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="34"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW78099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="385" mass="42884" checksum="5DEF4393204AF7C3" modified="2014-03-19" version="1">MSYEWILPEGIRSNTLRVNDLTVHLLEAGDPQNPLLVLLHGFPELSYSWRKIILPLAIAGYHVIAPDRRGFGRTIMLDRLDPSTSIEYDEDIQPFRSFNLATDIVALVFALGFTKVHAVIGHDSGSPVAAYCALIRPDMFQRVVMMSSPFAGPPSFPIGGSTSANPSIASLFAHMVEALAQLDPPRKHYVAYYSSPDANRDMTSSDLKHFFRAYYHMKSADWVPNDPHPLPALSAASFALLPEYYVMRLECTMPESVLPTSPSPDEIQSNRWLSDSEIDVYVAEYGRTGFQGGLNSYRCGLDVSGRSTSDLLILSGKKVDVPAMYIAGKKDWGTYQFPGAVEQMKNVCVRMGDRVRLVDGAGHWVQQEKPDDVVKLLLDFFEETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXI3</accession>
    <name>W4JXI3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_164154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550174.1">
        <property type="nucleotide sequence ID" value="XM_009551879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXI3"/>
    <dbReference type="GeneID" id="20667896"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_164154"/>
    <dbReference type="eggNOG" id="ENOG502SPX6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052689_1_0_1"/>
    <dbReference type="InParanoid" id="W4JXI3"/>
    <dbReference type="OrthoDB" id="3256525at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="424" mass="47573" checksum="4EE591EE60D8FB49" modified="2014-03-19" version="1">MATSQNGQPTAFSDIPNEIVLRIFGCATFVPGALEADVSDPFEASQPLKFDMGHQIKSLQMALDTKYSLVRVCKRWRTLAMPILYEAVSIHGLDGLYSVYQDLRNPNLQQAPDLGWWVRRMDLTLHDLVGEFEEIEDSVLSMIAYVFSRLPNLQILVVSIDTSAVEDMDVDDDSPPNRPIVDLVCGTIGAHCMPSLRMLSWESEPRPDSGIITALLGKQLYLQTVMIGGGDGADICPATLPQLPYLDFITLIHGDNEGHGISGTASFPALRQVHIRWIDEDFDCIRQFLAFQAPRLTTSYISLNETTGDSLYPVLEMNCPNLSHLILIGLVWRDFLHDEPKLPFPSRVTHLGISCKQLRASDQEYINLFTWIIARMHRSIRIIRFMDASVSEDLRHRHSGILAHALLPFAGSNIRVEDNEGNNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXS3</accession>
    <name>W4JXS3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_242526</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549897.1">
        <property type="nucleotide sequence ID" value="XM_009551602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXS3"/>
    <dbReference type="STRING" id="747525.W4JXS3"/>
    <dbReference type="GeneID" id="20668936"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_242526"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_15_7_1"/>
    <dbReference type="InParanoid" id="W4JXS3"/>
    <dbReference type="OrthoDB" id="1049195at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000145">
        <property type="entry name" value="Putative RNP domain-containing protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF64">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="116"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW77880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="192" mass="20945" checksum="25CF43FDB421B397" modified="2014-03-19" version="1" fragment="single">LPYRVRWQDLKDLFRKAGTVLRADVSLGPDNRSRGYGTVLLATAEDAGRAVDMFNGYSWQTRVLEVRLDRLPPDLDNPPGSGFTGSATAATLANASLGSIMANSNAAAGGWGAMSRNLFVGNLPFHCQWQDLKDLFRQAGTILRADVALGQDGRSRGFGTVVFATDTDAERAVQMFNGYEYNGRPLKVHFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYW0</accession>
    <name>W4JYW0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_239605</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549063.1">
        <property type="nucleotide sequence ID" value="XM_009550768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYW0"/>
    <dbReference type="STRING" id="747525.W4JYW0"/>
    <dbReference type="GeneID" id="20668831"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_239605"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="InParanoid" id="W4JYW0"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06627">
        <property type="entry name" value="STKc_Cdc7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF4">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW78752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="260" mass="28808" checksum="BDF79C348D2126CD" modified="2014-03-19" version="1" fragment="single">GNCIGRGQFGSVYRALNLNTGQMVAVKRIGLEGLKEEEVTQLMREVDLVKSLSHPSIVKYEGMARDENSLSIVLEYAENGSLGQTLKAFGKLNERLVASYVVKILEGLHYLHRSDVVHCDLKAANILTTKNGNVKLSDFGVSLNLRAMEREIKDVAGTPNWMAPEVIELKGASTKSDIWSLACTVIELLTGRPPYGDIANSMTVMFRIVEDAMPPIPDGCSEPLVDFLEQCFNKDPSLRPSAELLCEHEWLKKHWGAHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4K022</accession>
    <name>W4K022_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_460059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549343.1">
        <property type="nucleotide sequence ID" value="XM_009551048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K022"/>
    <dbReference type="STRING" id="747525.W4K022"/>
    <dbReference type="GeneID" id="20677040"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_460059"/>
    <dbReference type="eggNOG" id="ENOG502S6K1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009568_0_1_1"/>
    <dbReference type="InParanoid" id="W4K022"/>
    <dbReference type="OrthoDB" id="107110at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33266">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33266:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="825"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="838"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="996" mass="111635" checksum="78FD0189E621945D" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0P3</accession>
    <name>W4K0P3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_434979</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547985.1">
        <property type="nucleotide sequence ID" value="XM_009549690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0P3"/>
    <dbReference type="STRING" id="747525.W4K0P3"/>
    <dbReference type="GeneID" id="20674791"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_434979"/>
    <dbReference type="eggNOG" id="KOG1359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_3_0_1"/>
    <dbReference type="InParanoid" id="W4K0P3"/>
    <dbReference type="OrthoDB" id="2382073at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF77">
        <property type="entry name" value="8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="5">
        <location>
            <begin position="33"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW79398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="446" mass="48959" checksum="137538A571BE7F20" modified="2014-03-19" version="1">MEPTLNAYLNRHLSERLFAVTIEDDAVISPTADFSSNDYMSLTKDPALRQIFLERLSLEPNILGATGSRLLDGNTPTHLALEALLKHFYTGPGAAAVFNSGYDANLSVFSTLPQKGDAFVFDELIHASIRDGMFASRARNMMFPFSHNSITSLEVTLRQVVKDHPHLADGNGTIFIAVESLYSMDGDFAPLSDIVRVMHETVPPQSQHLIIDEAHTTGNYGAGGRGYVSALGLEDYVHTRIHTFSKALAFGGAVVVTSPLNHKYLMNFARPMLFATALPICNIIGIDCIHSWISSERGRELADKLNGNAIYFLGLLVRSLHGIPTSLLCPILTGHTFRAPLPTLSTNSSTSTSDLTSSTLYVSPVFPIKSSQPVALAAHLRAKGYWTRAMPFPVVDRGQERVRICVHAEHTHDDMDQFVGELVRWARGRMAAAVEVPMDRQMAARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0S7</accession>
    <name>W4K0S7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_453746</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549549.1">
        <property type="nucleotide sequence ID" value="XM_009551254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0S7"/>
    <dbReference type="STRING" id="747525.W4K0S7"/>
    <dbReference type="GeneID" id="20676413"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_453746"/>
    <dbReference type="eggNOG" id="KOG4155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_32_1"/>
    <dbReference type="InParanoid" id="W4K0S7"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="16"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="100"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="143"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="185"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="228"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="264"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="307"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="358"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="401"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="447"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="490"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="533"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW79304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="590" mass="62825" checksum="18D80B24CF720FC7" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4K152</accession>
    <name>W4K152_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">GMC oxidoreductase 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">gor14</name>
        <name evidence="11" type="ORF">HETIRDRAFT_103798</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548140.1">
        <property type="nucleotide sequence ID" value="XM_009549845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K152"/>
    <dbReference type="GeneID" id="20665936"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_103798"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_0_1"/>
    <dbReference type="InParanoid" id="W4K152"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="9">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW79563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="660" mass="71971" checksum="E0F66D6686B69232" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4K192</accession>
    <name>W4K192_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_124459</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009549859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K192"/>
    <dbReference type="STRING" id="747525.W4K192"/>
    <dbReference type="GeneID" id="20666875"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_124459"/>
    <dbReference type="eggNOG" id="KOG0192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001450_0_0_1"/>
    <dbReference type="InParanoid" id="W4K192"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
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    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="518"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="840"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="845"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="873"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="891"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="554"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW79582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1203" mass="132046" checksum="4DAAE95F266395FE" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4K267</accession>
    <name>W4K267_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_321962</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548449.1">
        <property type="nucleotide sequence ID" value="XM_009550154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K267"/>
    <dbReference type="GeneID" id="20670801"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_321962"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_22_0_1"/>
    <dbReference type="InParanoid" id="W4K267"/>
    <dbReference type="OrthoDB" id="3252634at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="30"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW79913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="384" mass="43379" checksum="347124916951BADA" modified="2014-03-19" version="1">MRQDISWFVRTCHLCQIRQTRNVLIPPTVATPAPLFAKMYMDTMHMPTAGGFKYLVQGRCSVSHYPEFRMLRCETSSALADWIFEDILCRWGTLVEIVSDNGPAFVKALDQLAKKYYVRHIRISGYNSRANGIAERPHFDVRQALFKAVDGDQAKWNRAAHFVFWADRITVRRRMGCSPYFAATGTHPLLPLDIAEATYLLPPPTTALSTTDLIARRAIALQKRRSDLAHLRSSVVGARVQAAIRFEQQHLATLRDFNFHRGLLVLMRNTAIEKALNRKMRPRYLGPLLVISRNRGGAYILAELDGSVFDRPVAAFRVIPYFARRSLKLADLEALLDISQERLRAMEDSRSSDDDAEDDSADEDTDTSSVRSAEDDDAASATSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4K284</accession>
    <name>W4K284_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_103853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548047.1">
        <property type="nucleotide sequence ID" value="XM_009549752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K284"/>
    <dbReference type="GeneID" id="20665942"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_103853"/>
    <dbReference type="HOGENOM" id="CLU_066263_0_0_1"/>
    <dbReference type="InParanoid" id="W4K284"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW79460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="250" mass="27490" checksum="0ADF239A47F6BBC8" modified="2014-03-19" version="1">MSYHLYPTFNTQGWEESLSSMPQEQMDFAYTEPLDEHPPLAMNHYGPPTEALGYEQYAACHPQPGYTMAGPSHVVSGDVHCPQQMLPAGIATIKQHRQRLASALEGSTSHAVQPQYGAVEIMEPSTVGSSAPPTGTSVEVVTSLRRSQPGVHPVLSQLAGAVAGPARSSKGFEDSFEQEHSQGCKDAVQREVPHEGCNAGAQDEMKKDIMPHRKVQWEKAHKKGSLWCDQCHREFNRPDSLSNHKRTIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2A8</accession>
    <name>W4K2A8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_322022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548468.1">
        <property type="nucleotide sequence ID" value="XM_009550173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2A8"/>
    <dbReference type="GeneID" id="20670807"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_322022"/>
    <dbReference type="HOGENOM" id="CLU_1086091_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2A8"/>
    <dbReference type="OrthoDB" id="3235325at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="256" mass="28661" checksum="9F1D8AA914C3EEDE" modified="2014-03-19" version="1">MQDRIAPIKWGNASVRAHDLLVRRLHSKYPELRLCQDNWKIEYIVTNDYPKWYESHSRKRELVKLEEGAVEGTRPSKRCLGAPILATKRGRLETQREDGNEKENSQVHIVCCPLPCSLPPLEKPQLEPPAKPVDDLEDMYGDLPSYPSGVDGHEYRNKKDMDVPWTSSSSGCHKDHEDTDMDICKNMVVSAPGAAHVAPHAPINIGIMEVLDPAKAALSTLRMGPLRGKEREGDFPGFHSDMVESFTAIVVSTISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2R2</accession>
    <name>W4K2R2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Choline dehydrogenase 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">chd7</name>
        <name evidence="13" type="ORF">HETIRDRAFT_103734</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548207.1">
        <property type="nucleotide sequence ID" value="XM_009549912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2R2"/>
    <dbReference type="GeneID" id="20665929"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_103734"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_0_1"/>
    <dbReference type="InParanoid" id="W4K2R2"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844272" evidence="10">
        <location>
            <begin position="28"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="11">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="12">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="563"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="606"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="562"/>
            <end position="563"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW79640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="626" mass="66219" checksum="8C5E51CE9FC9F7E8" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2Z3</accession>
    <name>W4K2Z3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_171330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009550404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2Z3"/>
    <dbReference type="GeneID" id="20668329"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_171330"/>
    <dbReference type="eggNOG" id="ENOG502RW2M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048769_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2Z3"/>
    <dbReference type="OrthoDB" id="3049938at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="269"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW80187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="383" mass="43795" checksum="B6B84B91AAC6B199" modified="2014-03-19" version="1">MSDRGNKPKDFDGTRSKYREWIYECHMYILANPTKYDTDKDKTLMVLSYMREGTASLFAQKYYFDRELREYKPTETRKVWGTFKDFLNELAAAFKDESLEQKARQKLFTMRMGKRSADEFVTDYLMTAGESGFDLESTVDYFRRAIHPEILKQIYRLPDMPTTMDDWVKYTRRFDNQWRELQSIKSSVPSATVRSNNPFRYNSSNTPSSMNNSVVPMAVDSVRTTLTDEERNRLRMEGGCFYCRQKGHMANQCPVRGSSRVHEGSARYVQQSSGAMGNRSAQTGGRMGGGGSSYGRTFSTGTSSSPQGGTATQGRSVATTNPFRARLAARQAHAPGPDAPVRETEPEISREEIQRVIGKMRWDEQEALLQELSEMSKRKESDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3A6</accession>
    <name>W4K3A6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tetrapyrrole biosynthesis uroporphyrinogen III synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_322098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548356.1">
        <property type="nucleotide sequence ID" value="XM_009550061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3A6"/>
    <dbReference type="FunCoup" id="W4K3A6">
        <property type="interactions" value="288"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K3A6"/>
    <dbReference type="GeneID" id="20670814"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_322098"/>
    <dbReference type="eggNOG" id="KOG4132">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051874_0_1_1"/>
    <dbReference type="InParanoid" id="W4K3A6"/>
    <dbReference type="OrthoDB" id="5595751at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390">
        <property type="entry name" value="UROPORPHYRINOGEN III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390:SF0">
        <property type="entry name" value="UROPORPHYRINOGEN-III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="HemD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW79810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="290" mass="30539" checksum="BBA83D43789F0B3C" modified="2014-03-19" version="1">MATPVLLLRAPTSPPETDRYETALRSAGFHPVSVPVLETAFANIHGLSELLAAGPQDVGGVIVTSARAAEAWANAVESVAHLGNGDEANWTAMPFYAVGAATADSLSSISSSSRPLLCPKDIRGAAESGTAELLAHFILSDLDTSAPGTKLLYLTGDKNRETLPGILKSGGVELMGLQVYATQGSKTFRTDLEEALRRFRAATTPWWVTFFAPSAAAYVVPILRAYFLLSTSSRPSGDIEGSSGKKSARIAAIGPTTSEFLDGQLGLLVEVVPQRPSAEELTKALRTEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3C8</accession>
    <name>W4K3C8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_229282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547069.1">
        <property type="nucleotide sequence ID" value="XM_009548774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3C8"/>
    <dbReference type="GeneID" id="20668702"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_229282"/>
    <dbReference type="eggNOG" id="ENOG502SXYS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068189_0_0_1"/>
    <dbReference type="InParanoid" id="W4K3C8"/>
    <dbReference type="OrthoDB" id="128646at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="45738" checksum="955FA811DFA470E2" modified="2014-03-19" version="1" fragment="single">MKTRGAPSLRIETELIGKNRKAATQALVDSGATGIFMHPNFVEKHGIRTSRTPHPIPVNTVQNTEFKGGPITRFAELKLRVLGEQGGAHIESARFYIAEIGKEDVILGTDWLLEHNPEVDWHAYGLHFTRCPPTCDIIGGPVKAKRAFRKPGRQEPGVRRMVTVPRERDYSIPLQKPEKGQLGRKVGNTTVPHPRILPKIRGSQPKGTNREYSLRTQARNYTAPTWAEEEPQEGGGPLSALPSTDLDEEGVYLVRYLETGQLEALELYNDHEESYDIHRVETSVANTPARKAEPAKAAIGKQTKHTNSQKLAEEASKGKPELSFEEIVPKEYWSYRKVFKGRKPGKLPPKRPWDHKIELKDDMEHSLRPKLYSLSPMEQEELKKFIDDSLKKGFIRESKSHMASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3T5</accession>
    <name>W4K3T5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Na(+)/H(+) antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_154778</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547151.1">
        <property type="nucleotide sequence ID" value="XM_009548856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3T5"/>
    <dbReference type="GeneID" id="20667522"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_154778"/>
    <dbReference type="eggNOG" id="KOG4505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008635_5_0_1"/>
    <dbReference type="InParanoid" id="W4K3T5"/>
    <dbReference type="OrthoDB" id="2190219at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF4">
        <property type="entry name" value="NA(+)_H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="26"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW80394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="476" mass="51384" checksum="8A03F19E2C818E60" modified="2014-03-19" version="1">MATELLQVTTPGLAYVLLGGFVVAFSMVSLLIREKFYINEVVLGTAFGILIGPYVANIFNPRSWDVETNALTLEVMRIVLATGLFAIGVELPQSYMAKHFKSLLIMVVPTMAFGWLVCAGFIHLLFPSLDFTSALAVSACLTPTDPVISAAIVGGKFATKHVPVNLRRLVVAESASNDGLAYPFLTISLYLSTESYRSAFRDWLLIGWLYQVILGVVIGAIIGLMFSYLIKYTHGRGFIDRESYVAQYLALAIFTIGVTSTLGSDDLLAAFAAGSAISWDGHFNTQIEDEVFSSVIDLVLNCAAFIYIGAWLPFDQFNQAALGITPWRLVVLTVAILTLRRIPPLLLLYKLVPEISGWREALFAGHFDPIGVGAVFISTLAITKLEQQTQDPSQEQQILIDSLSPIVSFLVLCSIMILPLAHAHRAGHRGARLAPLGTALAPAPPHVPARLCPGLGGAVPHALAAGVPSPPARGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3V2</accession>
    <name>W4K3V2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_452014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547171.1">
        <property type="nucleotide sequence ID" value="XM_009548876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3V2"/>
    <dbReference type="GeneID" id="20676220"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_452014"/>
    <dbReference type="eggNOG" id="ENOG502SS3Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044614_9_3_1"/>
    <dbReference type="InParanoid" id="W4K3V2"/>
    <dbReference type="OrthoDB" id="2744793at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW80414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="391" mass="42004" checksum="60FEC8A9359D485B" modified="2014-03-19" version="1">MSSTANNTASALQTFGDNIVQSGVALVCETLLYGMYLILIFFSTYTLCRKGFRSAANVAMLVVTLTMFAMSTTLWASELAILIQRVRRGLVTRPDLSVPDNVTDAAIASRVEIWLPEVFFSFEFVLGDSVVIWRAWALWQDNIKVLLAPLCLAVASALAAFALLGCGAKAHFGRVADAPALCHNSEVTSWVLSIAANVIATGIIGYKAWEYRQFIRKSLGSKSRRTQIEKVLALLVDSGAVYFVLWVPQILGFFPITFHPGPAHFTSVVFGSVCKQIVGLYPTIVVVLVNLHRSVLDSPNASHTHARAHHSDLQQTNMRFASVPGVAASAAVVTETGIGSVRRSAVIVDAAQMRSGVGQTEEHRSSRSEDGASSASVAGVGEKKAEGSESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4A2</accession>
    <name>W4K4A2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL39</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L39</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_476366</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL39 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547388.1">
        <property type="nucleotide sequence ID" value="XM_009549093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4A2"/>
    <dbReference type="FunCoup" id="W4K4A2">
        <property type="interactions" value="182"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K4A2"/>
    <dbReference type="GeneID" id="20677679"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_476366"/>
    <dbReference type="eggNOG" id="KOG0002">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181948_3_0_1"/>
    <dbReference type="InParanoid" id="W4K4A2"/>
    <dbReference type="OrthoDB" id="6332053at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein-like L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.10">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00629">
        <property type="entry name" value="Ribosomal_eL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000077">
        <property type="entry name" value="Ribosomal_eL39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020083">
        <property type="entry name" value="Ribosomal_eL39_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023626">
        <property type="entry name" value="Ribosomal_eL39_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970">
        <property type="entry name" value="RIBOSOMAL PROTEIN L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00832">
        <property type="entry name" value="Ribosomal_L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48662">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00051">
        <property type="entry name" value="RIBOSOMAL_L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW80668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="51" mass="6366" checksum="656E0F761C2494E3" modified="2014-03-19" version="1">MPSQKTFRTKRILAKASRQNRPIPQWFRLKTDTKIQYNAKRRHWRRTKLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4E7</accession>
    <name>W4K4E7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HlyIII-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_154894</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547401.1">
        <property type="nucleotide sequence ID" value="XM_009549106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4E7"/>
    <dbReference type="FunCoup" id="W4K4E7">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K4E7"/>
    <dbReference type="GeneID" id="20667532"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_154894"/>
    <dbReference type="eggNOG" id="KOG0748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021163_0_0_1"/>
    <dbReference type="InParanoid" id="W4K4E7"/>
    <dbReference type="OrthoDB" id="5585746at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF97">
        <property type="entry name" value="ADIPOR-LIKE RECEPTOR IZH3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="514"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW80682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="61423" checksum="BC35F52012C318A7" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4G6</accession>
    <name>W4K4G6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_476431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547444.1">
        <property type="nucleotide sequence ID" value="XM_009549149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4G6"/>
    <dbReference type="GeneID" id="20677685"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_476431"/>
    <dbReference type="HOGENOM" id="CLU_1787102_0_0_1"/>
    <dbReference type="InParanoid" id="W4K4G6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="145" mass="15634" checksum="371BAD63A4ED94A3" modified="2014-03-19" version="1">MRLLPRRARAAFVMHRCFFTVSSRGAHGGRERLQLGRGPLLVSLFSLALSFARRTDRPTARTHAPRSPMHTTTTRSSHGAGRFNIPRTAVAAAVARVIRAAPRVRAVVEADVVEAAVPTADAAGARSVGCRQPSDAVLYVLEKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4T4</accession>
    <name>W4K4T4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_453062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548595.1">
        <property type="nucleotide sequence ID" value="XM_009550300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4T4"/>
    <dbReference type="GeneID" id="20676341"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_453062"/>
    <dbReference type="HOGENOM" id="CLU_035919_0_0_1"/>
    <dbReference type="InParanoid" id="W4K4T4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="557" mass="61276" checksum="1769BAF84EDF07EC" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4K601</accession>
    <name>W4K601_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_459597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547863.1">
        <property type="nucleotide sequence ID" value="XM_009549568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K601"/>
    <dbReference type="STRING" id="747525.W4K601"/>
    <dbReference type="GeneID" id="20677006"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_459597"/>
    <dbReference type="HOGENOM" id="CLU_559040_0_0_1"/>
    <dbReference type="InParanoid" id="W4K601"/>
    <dbReference type="OrthoDB" id="2884925at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="506" mass="56818" checksum="E4F2E21EEA05E6AA" modified="2014-03-19" version="1">MLTSLPGTQWLTQTWNKGHLLSIRRQTPSSPLTSPISILFPELLLSIFELIPFLWQPDEPSRFYDINWIAITHVCRRWRIIALNAPFLWRDIEFSTPRWTQEMLLRSQSIPINIRFHLDFLKYPPTMQKVIALAMGNIQRVRSLRLTGQVVETLIQCTTPALLLEELHLEYAAMPPPANLFIPDSLFDGSAHKLRSLFLKGLSIHLTSPLLPGLSSLTVQGDSRSPRHSLARWLDALTRMPKLETLCLIQALSRTSHAQTQGTDTPLPPTVLLPHLRTLAFTSNSLTDCVEFTRRLAIPSSTSIELRTYVASIDELTPHAIVPSYAHTPVTAFRITHTAIGFSIAGSLGDPDIPAFSLSIVIYEERSLIAQGILHTLAHFNVKSVRSLLIDLGGMTLDWAPVLSCFPLVNTIHVRGSTLHTFPKALAHSDALICPHLRRLEFEHRTPTYGKRIDETFFRILRDAVDARWANGMSLEELIVFGETLSHSGSVDTAAIGSRKIPKKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6C9</accession>
    <name>W4K6C9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_51087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545832.1">
        <property type="nucleotide sequence ID" value="XM_009547537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6C9"/>
    <dbReference type="GeneID" id="20678169"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_51087"/>
    <dbReference type="eggNOG" id="ENOG502SMD0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040578_2_1_1"/>
    <dbReference type="InParanoid" id="W4K6C9"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF1">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22465" checksum="5F39938FB580573F" modified="2014-03-19" version="1">MAGQPWNDAREALAGLAELYARYDTDGLDVYFLNDPRCRVNLRVRATIGAIWASLPLRRQTPTGTKLKEILDKYIPLVENKRVLHKPINIIVITDGAATDDPVETIVEAARRLDRNEVPHRQLGIQFVQIGNDLGATEALKELDNELEHQYLIRDMVDTTLFDPRNPQFKAETLLKIMMGAVDQPLDRGYPFRRSASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6F2</accession>
    <name>W4K6F2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HMG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_319999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547617.1">
        <property type="nucleotide sequence ID" value="XM_009549322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6F2"/>
    <dbReference type="STRING" id="747525.W4K6F2"/>
    <dbReference type="GeneID" id="20670636"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_319999"/>
    <dbReference type="eggNOG" id="ENOG502S87Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069971_0_0_1"/>
    <dbReference type="InParanoid" id="W4K6F2"/>
    <dbReference type="OrthoDB" id="5598737at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040648">
        <property type="entry name" value="HMGXB3_CxC4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18717">
        <property type="entry name" value="CxC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG" evidence="1">
        <location>
            <begin position="41"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="218" mass="23683" checksum="4F58F072D530D5FA" modified="2014-03-19" version="1" fragment="single">MKAGGQDDGLGLQGCISHTSIPPPRWCSLPHEASLYAPRLSTDSMHFVLGVAPRCCCGFEPQTSGGFISQSATVFGFTNKYEATIDVLPCPVCCHRRRLVGPDLGNIGIFNWNNLHLFTHELLNAFTSAFTTSETPFSAFCATVRHSYEEHSLGNKFCSDETFVRAWFAFVRLQKLDSGMTCPTCGPNPSVVIADGVSLGTHSSKLTAVVKPPTYTDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6Y7</accession>
    <name>W4K6Y7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aspartic peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_146489</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547783.1">
        <property type="nucleotide sequence ID" value="XM_009549488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6Y7"/>
    <dbReference type="FunCoup" id="W4K6Y7">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="GeneID" id="20667141"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_146489"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_1_2_1"/>
    <dbReference type="InParanoid" id="W4K6Y7"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000115">
        <property type="entry name" value="Lysosomal aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF6">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844113" evidence="8">
        <location>
            <begin position="19"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="9">
        <location>
            <begin position="89"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW81110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="486" mass="49804" checksum="3BFFA9C76CDC0E20" modified="2014-03-19" version="1">MLPHILLALLFLASSSSAAPSTSGAIHIPITRRSHNPAKRSAEDNIDRLSRAADFIRNRYGYSSPSTTVQRRQSSAAIPITNQGSDTSYFGVVNIGTPSQSFDVVLDTGSSDLWVAANNCQSCPSGTPEFDPSKSTSLQSSTTNLELHYGSGAVAGTLAADTVSMGPYTIQQQTFVVVDQITSGLIDGSLAGIMGLAFESISNTQATPFWQALLNNNQFQSPEMSFWITRFLNDASATDEEPGGVLTLGGTNSTLFTGDIDFQNFPSGTQASFWLQTVTAVTVNGKSVTIPTGNSALAAIDTGTTLIGGPSAAVASIWAAVPGSRALTGQMAGFFGFPCTTNVEISMSFGGKSWPISINDMNLGTVGSGLCAGGIFDISQGTDITTGSGTPNWIVGDTFLKNVYSVFRANPPSVGFAELSNAAGGSSGTPGSATGSATITGTSNPLPSVSSSAASAAHAGSGTAIMAIGLSLLVSLFTGRFLLGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7K2</accession>
    <name>W4K7K2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_444926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546391.1">
        <property type="nucleotide sequence ID" value="XM_009548096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7K2"/>
    <dbReference type="GeneID" id="20675603"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_444926"/>
    <dbReference type="eggNOG" id="ENOG502S1AV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052711_1_0_1"/>
    <dbReference type="InParanoid" id="W4K7K2"/>
    <dbReference type="OrthoDB" id="21214at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="276" mass="31510" checksum="C21E114979036962" modified="2014-03-19" version="1">MAIIDPQDLERLWALLTELAEQTNSHRHYTANLHAQANNVKNQAIHSQTGFVLRRFNLDKSQEEYDAELERMNTVMAADNQALLHDNKQLNALIKEYETTLENVMNQFRNRAHEVQEQELSLVREYETRLIARETEEHAQRLAASSAYSESLTRMSRMLRKQLRALGGEDVTEVPAGAQDAYRPEEWNALAAADWALERESELARLEKENALLRRLMGDESLNDDGPANERPVPLTVEEVRQRLVFPTRDKSVKLGGAKGTVGPFATYKRMRALAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8E1</accession>
    <name>W4K8E1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_244556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546639.1">
        <property type="nucleotide sequence ID" value="XM_009548344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8E1"/>
    <dbReference type="GeneID" id="20669058"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_244556"/>
    <dbReference type="HOGENOM" id="CLU_178721_0_0_1"/>
    <dbReference type="InParanoid" id="W4K8E1"/>
    <dbReference type="OrthoDB" id="2635857at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="70" mass="7849" checksum="2817FB6D035AF1AB" modified="2014-03-19" version="1" fragment="single">MQKHTFGNTWEWKHTLALLNLKTALTSKPVLRKLVFDGTPFIITTDGCQQGFGAVLTQEFTTELAGRKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9V9</accession>
    <name>W4K9V9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_426177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544894.1">
        <property type="nucleotide sequence ID" value="XM_009546599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9V9"/>
    <dbReference type="GeneID" id="20674087"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_426177"/>
    <dbReference type="eggNOG" id="ENOG502SS3Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044614_9_3_1"/>
    <dbReference type="InParanoid" id="W4K9V9"/>
    <dbReference type="OrthoDB" id="2744793at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW82539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="366" mass="40544" checksum="BCAC49AE82F7542B" modified="2014-03-19" version="1">MSSNETFLLQGLGDDIIRDLIGIACGSIFYAYGDTYSDMILTLNNDAHEHDRRRGLTSKPVLGMLVVTLVMFALSSALWVITLALRVRRTHLELVANSSEALEDRISDANEATKTIKWLVDILFSFEFVLGDIVVIWRAWTLWQGNWKIMLTPIALLVGSVVAAFIFFGCIVSSDFPLDVDEPNLCNNAEIASWAMSMATNAAATILIAYRTWQHRQSIKKILGSTDKVTGAERILWLLVESGLIYFVLWVPQVVGFSPAAYTVPSARLAEDILNDIGNQIVGLYPTMIVVLVNLNRSVWDSTEFSHQVNHSTMCFASTPGHTATVATNNGQRHASIHFETVLHSGSISDPDSEHRDDKPESVDMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAC4</accession>
    <name>W4KAC4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cep57 centrosome microtubule-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_434337</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546615.1">
        <property type="nucleotide sequence ID" value="XM_009548320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAC4"/>
    <dbReference type="GeneID" id="20674742"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_434337"/>
    <dbReference type="eggNOG" id="ENOG502S31Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007735_0_0_1"/>
    <dbReference type="InParanoid" id="W4KAC4"/>
    <dbReference type="OrthoDB" id="76453at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051756">
        <property type="entry name" value="Centrosomal_MT-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024957">
        <property type="entry name" value="Cep57_MT-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025925">
        <property type="entry name" value="PPC89_CLD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336:SF9">
        <property type="entry name" value="SPINDLE POLE BODY PROTEIN PPC89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336">
        <property type="entry name" value="UNCHARACTERIZED DUF1167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14197">
        <property type="entry name" value="Cep57_CLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06657">
        <property type="entry name" value="Cep57_MT_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPC89 centrosome localisation" evidence="7">
        <location>
            <begin position="515"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Cep57 centrosome microtubule-binding" evidence="6">
        <location>
            <begin position="952"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="183"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="589"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="879"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="421"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="589"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="647"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="667"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="686"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="708"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="727"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="785"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="840"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW82036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1066" mass="118759" checksum="9822E98C9D551231" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KB29</accession>
    <name>W4KB29_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_439594</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">PML body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545327.1">
        <property type="nucleotide sequence ID" value="XM_009547032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KB29"/>
    <dbReference type="STRING" id="747525.W4KB29"/>
    <dbReference type="GeneID" id="20675167"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_439594"/>
    <dbReference type="eggNOG" id="ENOG502S394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042307_0_0_1"/>
    <dbReference type="InParanoid" id="W4KB29"/>
    <dbReference type="OrthoDB" id="9975959at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070260">
        <property type="term" value="F:5'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051547">
        <property type="entry name" value="TDP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15822">
        <property type="entry name" value="TRAF AND TNF RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15822:SF4">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="11">
        <location>
            <begin position="38"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW83042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="311" mass="34804" checksum="83619DF4BFB6FB40" modified="2014-03-19" version="1">MTDILRNIPIVRWSQRADSWVLAKNRPDAYLPMSITLLTWNIQHDVPNAWERHQAAMTYIQHKAFGCYDGRAPRPGVIMLQEVGADAFNALLEHAWVRTHFVVMPPGPQYWPYGARYGVVTLVPRHMSISAATSVEFGGSRMGRNMLMVDVWVNMSLDALGCEPKIIRIANTHLESLPGGVIWRAGQLRTVAQWLKDFQVKGGVVCGDMNALVPADEKFVAMNGLVDAWEKSSAHVAAVGDGDMEENDGTTWGFQPRSDFKPARLDKMLYAEKRAYELERPWAVGVGLKTKSGQWVSDHYGLMSILRVLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBC7</accession>
    <name>W4KBC7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_316216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545387.1">
        <property type="nucleotide sequence ID" value="XM_009547092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBC7"/>
    <dbReference type="STRING" id="747525.W4KBC7"/>
    <dbReference type="GeneID" id="20670302"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_316216"/>
    <dbReference type="eggNOG" id="ENOG502S46I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_44_8_1"/>
    <dbReference type="InParanoid" id="W4KBC7"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03139">
        <property type="entry name" value="GATase1_PfpI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF15">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="12"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="217" mass="23350" checksum="7BF17719EA73A092" modified="2014-03-19" version="1">MSTTDLPLVYGILLYDGMAILDIYTLLEYLNIISLDLPIKIHLISTSSSDIVSTKVGQSYVGNAQRMVADYSLDNAPDLDVIAIPGGTTEEVISSGRVAKFLKARYPTLKHLIGICTGGAIIAASGLLDNKRAAGTKSVWSWVSTLGTNVTWIPKARFMNDGNIWTSSGLTAGLDLSYALIKEVYGREVAEKAAMVLEYIPSEDPLADPFAAKYGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBP8</accession>
    <name>W4KBP8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_119768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545491.1">
        <property type="nucleotide sequence ID" value="XM_009547196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBP8"/>
    <dbReference type="GeneID" id="20666662"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_119768"/>
    <dbReference type="HOGENOM" id="CLU_032924_0_0_1"/>
    <dbReference type="InParanoid" id="W4KBP8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="468"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="100"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW83213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="502" mass="54120" checksum="0D2C0B4F3340DFBE" modified="2014-03-19" version="1">MSALLSALKTKLGEYMLSLPDGAAEYEDYEAWARGFAKRVAVLDRSARGQDLPELADWIAEAERGLDHMATDDWLAWGTRILPQRAARFATQQQRQAAEAQALEEESARVAIAEREAEEAEVARAAAALRVAEEDRQRRREALVEAMFDGSMDPEEGDRQMAVLEAESAGLLPLFLPSPSDAPTLSDAPAPAASSSLLPLPADAGLASTTEALGRMSVDSTLPTPSADSKGKQRAGAVIVEFARQRTPTEGRVVLPLRLGAGRMSTVRSPVERNGAGKLLQDPPGLLPGDVLAEYACHRCATEFATVAPRCYTRPGQVSCLKCADDRKGCSFQPGWTSKEKGKGQVKAKSGAKSVENERPMKKRKVEVLVPERSAGESIARSKAVRSRKPVKRLLTTTQRLPVPSRSSRPTRPTSTAAPSPELLRLSPSIARGVVSEIRYRIAVAEGSRTFLARSITMWRAELEALEARSGPSAPSDVVLVEDLSEADDSGRSESGDFVPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBU9</accession>
    <name>W4KBU9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_439429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544906.1">
        <property type="nucleotide sequence ID" value="XM_009546611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBU9"/>
    <dbReference type="GeneID" id="20675145"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_439429"/>
    <dbReference type="HOGENOM" id="CLU_2320699_0_0_1"/>
    <dbReference type="InParanoid" id="W4KBU9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="99" mass="9656" checksum="76055ADB4E3B4EAE" modified="2014-03-19" version="1">MAVRGKGKYHPLSGADVGAGAGTDAGTQHHQLRLAERGRRMSAPGTVGSGVGAFGLELGLGLSMPMPMSGASLRRGAGAGAGVGTGGVGERGERGESRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KC96</accession>
    <name>W4KC96_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_57592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544672.1">
        <property type="nucleotide sequence ID" value="XM_009546377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KC96"/>
    <dbReference type="STRING" id="747525.W4KC96"/>
    <dbReference type="GeneID" id="20678401"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_57592"/>
    <dbReference type="eggNOG" id="ENOG502S3G3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_32_2_1"/>
    <dbReference type="InParanoid" id="W4KC96"/>
    <dbReference type="OrthoDB" id="2729552at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="85" mass="9655" checksum="B6BC4D80410CB311" modified="2014-03-19" version="1">MVAEPIFNVDGMANKGGKITDKACLLMRMENKGDYHDEQYELLATNLGGEDIILETDWLHKHNPQIDWVKNNLTFSTCAERCLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCY5</accession>
    <name>W4KCY5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucanase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">gh7.1</name>
        <name evidence="11" type="ORF">HETIRDRAFT_38802</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544628.1">
        <property type="nucleotide sequence ID" value="XM_009546333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCY5"/>
    <dbReference type="SMR" id="W4KCY5"/>
    <dbReference type="STRING" id="747525.W4KCY5"/>
    <dbReference type="GeneID" id="20672341"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_38802"/>
    <dbReference type="eggNOG" id="ENOG502QPHV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020817_3_2_1"/>
    <dbReference type="InParanoid" id="W4KCY5"/>
    <dbReference type="OrthoDB" id="412382at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.100.10:FF:000001">
        <property type="entry name" value="Glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844411" description="Glucanase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW83195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="458" mass="48922" checksum="003C7FA1C8961724" modified="2014-03-19" version="1">MYRSAALLSFSLLAVVYGQQVGTQTAENHPKLTVSQCSAGGSCTTESRSVVLDSNWRWLHTTSGTTNCYTGNTWDASLCPDPVTCAQNCALDGADYSGTYGISTSGNALTLKFVTNGPYSTNIGSRVYLMSADDTNYEIFKLKNQEFAFDVDMSNLPCGLNGALYFVEMDADGGLSRFPNNKAGSKYGTGYCDTQCPQDIKFINGEANILGWTPSSSDSNAGTGQYGSCCNEMDVWEANINSAAVTPHVCNVQGQTRCSGTQCGDGDERYDGICDKDGCDFNSFRMGNQTFLGPGKTVNTNSKFTVVTQFLTSDNTTTGTLHEIRRLYVQNGKVIANSKTNIAGMSQFDSITDDFCNAQKTAFGDTNSFENLGGLNVMGQAFDKGVVLVMSVWDDHEANMLWLDSDYPTTSSASTPGVARGTCATTSGVPANVESQNPNSSVVFSNIKIGPIGSTYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4KD03</accession>
    <name>W4KD03_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_439698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545488.1">
        <property type="nucleotide sequence ID" value="XM_009547193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KD03"/>
    <dbReference type="STRING" id="747525.W4KD03"/>
    <dbReference type="GeneID" id="20675177"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_439698"/>
    <dbReference type="eggNOG" id="ENOG502SQDH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045218_2_0_1"/>
    <dbReference type="InParanoid" id="W4KD03"/>
    <dbReference type="OrthoDB" id="5569250at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="278"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="478" mass="54710" checksum="78336421B64B661C" modified="2014-03-19" version="1" fragment="single">MEHVERLEPPIVQCGLYGVEMLSRGPCVNHAINVLIIDDVMWIWWYDRQGAIQTQGINFVQDLPRFLILLFAFQRFKLEDWGFNTILDPQSKIVHDLKKVHQTNRSLPKSHFVFPPPELSVSAPVETTVLTKSPVYHVYSLVGRGTSVFSGTACTKAPSTRGSGIPQGSGKGPVAVDDISFATPDKDEKVVVKIYWPEESRLSEGRIISEAYKRGEGNLDIVEHLPKMYLEHDFPEHSTNHIRDALRLTRPDGRRATRILRLAVFLKLDPIIALGGEEFMKAYLDCVRCHFALWTLGIQHSDLSLSNVMINDQKRGILNDWDLATIEGISKHDGCDRTGTVPFMALDLLKPSYWEGKIKRQYHHDLEGFLWILPYVCLQYKDGNMVTNPLKSWNTGHYAICREKKSDFLRNLRTKPHLIPKATSSYEWEWLVFHRFVQRIDNNWRSPLTNEAIAAAIKGNMELATSVPTPMDIYAEFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4KD20</accession>
    <name>W4KD20_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_46925</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543195.1">
        <property type="nucleotide sequence ID" value="XM_009544900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KD20"/>
    <dbReference type="GeneID" id="20677283"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_46925"/>
    <dbReference type="eggNOG" id="ENOG502S7YR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088618_3_1_1"/>
    <dbReference type="InParanoid" id="W4KD20"/>
    <dbReference type="OrthoDB" id="5316007at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052479">
        <property type="entry name" value="GPI-anchor_Adhesion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185">
        <property type="entry name" value="SERINE/THREONINE-RICH PROTEIN ADG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185:SF1">
        <property type="entry name" value="UPF0619 GPI-ANCHORED MEMBRANE PROTEIN C1322.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844412" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="3">
        <location>
            <begin position="22"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW83752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="137" mass="14401" checksum="AA827B3B41293908" modified="2014-03-19" version="1">MRTVLALAAFAASALAYQVTEPSQTQGWTTVGPNIVTWDRVSTDTTNFTLVLTNQNRNLLPTDEILVAFVDGTTGKQTASEPSAGWPVGTGFRVNLVQDTQHLSTIYAQSSEFTIAQSTSSVASSSTLAASSAAASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDG2</accession>
    <name>W4KDG2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein DOM34 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_123629</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the Dom34-Hbs1 complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:20890290). In the Dom34-Hbs1 complex, dom34 recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following ribosome-binding, the Dom34-Hbs1 complex promotes the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543629.1">
        <property type="nucleotide sequence ID" value="XM_009545334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDG2"/>
    <dbReference type="FunCoup" id="W4KDG2">
        <property type="interactions" value="462"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KDG2"/>
    <dbReference type="GeneID" id="20666832"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_123629"/>
    <dbReference type="eggNOG" id="KOG2869">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023334_3_1_1"/>
    <dbReference type="InParanoid" id="W4KDG2"/>
    <dbReference type="OrthoDB" id="10249111at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000004">
        <property type="entry name" value="Protein DOM34 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.870:FF:000001">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000008">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="entry name" value="Pelota, domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058547">
        <property type="entry name" value="Pelota_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00111">
        <property type="entry name" value="pelota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26356">
        <property type="entry name" value="Pelota_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="Dom34/Pelota N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW83897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="417" mass="46316" checksum="EF61C7D5153A4378" modified="2014-03-19" version="1">MKLVGKHIEKDHSGHVTVRPEEDEDMWHLYNLIQEGDRVRAPAIRRVQNVSATGSTESHRIRTTLTLQVTRVEFSPSAIPSSMESTSSAPPLPTASMQVSGRVAVENAHVKLGAFHTLDIEANRDVRIEKAEWDSIALERIRDACVPGRGAEVGAIVCGEGTAAFCLLSQHMTVVRQRIDVPIPRKRTGSATAHEKGLARFYNVLYQTFLRHIPYSSPGLRAIVIASPGWVRDAVFDHIMAEATRTSNKPLLAARSKFVRVHVNSPHVHSLVEVLKSPEIVAQLKETKFAREGIMLDKFFKMLGSDEQRAWYGPDHVALAIDRGAVGTLLISDELFRASDPVLRKKYVTLVEDVRDKGGEVLMFSSMHESGQQLNQITGIAAILTFPLDVEIVEAEEREAKEEEERKKREGEGGEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDH1</accession>
    <name>W4KDH1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_46835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543189.1">
        <property type="nucleotide sequence ID" value="XM_009544894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDH1"/>
    <dbReference type="STRING" id="747525.W4KDH1"/>
    <dbReference type="GeneID" id="20677228"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_46835"/>
    <dbReference type="eggNOG" id="ENOG502SM1F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033082_1_2_1"/>
    <dbReference type="InParanoid" id="W4KDH1"/>
    <dbReference type="OrthoDB" id="3220652at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="37"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="395" mass="44419" checksum="05917FB0DC9B3ABE" modified="2014-03-19" version="1">MTYPVASSTPANKPTSSHGAELDVQHQLCQDFWFPDGNIIVLAGACVFKIHRGQLERHSDVFKDMFSMPQPKMQSQIYGLPFIELYDSASDVYYLLKALYDGLYLKKPMPREFPFLAGVLRLSTKYLLESLRDICIAYLQRDFPLTLEEWDKREKTVTDPNGRYSPRDSVPNPILVINLARELSLHTILPAAFYDLARYGTSKTALGTVPYQPVFPPAAAVPPSSTVLASDATPTPPPTIRSNVFLSHEDLVTTFRGREAAQRSIAAFVSKELAERPLCASCAHKDDEDGRQCHESFYFITLNTLRSVGGIASGRDADPLFTLLQTIDMLHRTDFSDGERLCGLRLCCFCKLDFASAVNRARAELWKEIPAWFDLEDFEKLQKGESQSKEGWCLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4KE18</accession>
    <name>W4KE18_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Receptor-activated Ca2+ cation channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_106838</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="747525.W4KE18"/>
    <dbReference type="GeneID" id="20666195"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_106838"/>
    <dbReference type="eggNOG" id="ENOG502QU70">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009570_1_0_1"/>
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    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
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        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF1">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="265"/>
        </location>
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            <end position="328"/>
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    </feature>
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            <end position="361"/>
        </location>
    </feature>
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        <location>
            <begin position="373"/>
            <end position="398"/>
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    </feature>
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            <end position="429"/>
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    </feature>
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            <end position="460"/>
        </location>
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        </location>
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            <end position="541"/>
        </location>
    </feature>
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            <end position="968"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="988"/>
            <end position="1007"/>
        </location>
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        <location>
            <begin position="38"/>
            <end position="221"/>
        </location>
    </feature>
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            <end position="545"/>
        </location>
    </feature>
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            <end position="709"/>
        </location>
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            <end position="816"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW83281.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1104" mass="122058" checksum="335431BB8FE3EE6D" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
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    </protein>
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            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="137" mass="14948" checksum="346FDC3D08F43551" modified="2014-03-19" version="1">MSDTDELIRMAFQETCDGVPAPDPNGQFDMTRFNFPSNMFNAQPLPDISTFGLAGADLVPPEGTQEEADLMQMLEENGISIGLPARVPYMDHNYDQGLSLIFPSGTTSAMTRSATDGNGYATQSAVDPEWFSRSKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEF8</accession>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
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                <person name="Murat C."/>
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                <person name="Wiebenga A."/>
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                <person name="Yakovlev I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAPS reductase family. CysH subfamily.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009545536.1"/>
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    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00434">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002537">
        <property type="entry name" value="PRK02090.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509:SF1">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000857">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="5">
        <location>
            <begin position="47"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW84124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="276" mass="30135" checksum="7832D536FA1F7153" modified="2014-03-19" version="1">MSAPDLPTPLALPLSETDLAAINAHLRPLTPEEILRWALDHLPGLHQTTAFGLTGLVAIDMLAKLTPAPPPLIFLDTLYHFPETYALVEEVKTRYGVPVAVYTPEGCATVAEFEAKFGERLWETDEERYDFVVKVEPARRAYDALGVQSVITGRRASQGGARATLQPLEVDATGLLKLNPLFAWPFPLVDWYVRTHGVPRNALLDRGYRSVGDWHSTAPSGAGDAGERAGRWAGKEEKTECGLHVDYFAVKAKALKEQEQGSTTASDGASSRETKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEU6</accession>
    <name>W4KEU6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome c oxidase assembly factor 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_18584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PET191 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543149.1">
        <property type="nucleotide sequence ID" value="XM_009544854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEU6"/>
    <dbReference type="FunCoup" id="W4KEU6">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KEU6"/>
    <dbReference type="GeneID" id="20668620"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_18584"/>
    <dbReference type="eggNOG" id="KOG4114">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138069_3_1_1"/>
    <dbReference type="InParanoid" id="W4KEU6"/>
    <dbReference type="OrthoDB" id="282149at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018793">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_Pet191"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10203">
        <property type="entry name" value="Pet191_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW84362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="9535" checksum="8670E9D94A41A0B8" modified="2014-03-19" version="1" fragment="single">CDPLLTALKDCLLHSDCVLKQGYLPSQCLKEHFDDLPEQCKSLRQATFECKRGMLDMRKRFRGNNAGAVAAKIKEQSTSSADSVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4KF12</accession>
    <name>W4KF12_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U3 small nucleolar ribonucleoprotein protein IMP3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">U3 small nucleolar ribonucleoprotein protein imp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_312872</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544107.1">
        <property type="nucleotide sequence ID" value="XM_009545812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KF12"/>
    <dbReference type="FunCoup" id="W4KF12">
        <property type="interactions" value="195"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KF12"/>
    <dbReference type="GeneID" id="20669989"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_312872"/>
    <dbReference type="eggNOG" id="KOG4655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097281_0_0_1"/>
    <dbReference type="InParanoid" id="W4KF12"/>
    <dbReference type="OrthoDB" id="10248812at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000006">
        <property type="entry name" value="U3 small nucleolar ribonucleoprotein IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="12">
        <location>
            <begin position="4"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="11">
        <location>
            <begin position="109"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW84433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="183" mass="21408" checksum="05D9EBDF1B6F232E" modified="2014-03-19" version="1">MVRQLKHHEQKLLKKVDFLNWKQDANVREIKVMRRYHIQDREDYHRYNKLCGSLRSLAHRISLLPAQDPFRTRMEGQILSKLFDMGVLNSQAKLSDVDNKLTVAAFCRRRLAVIMVMAKMAETVSAAVKFVEQGHVRVGPDTVTDPAYLVTRHMEDFVTWVDTSKLKRTVMTYNDELDDFDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFD7</accession>
    <name>W4KFD7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HETIRDRAFT_449612</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Microsome membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543744.1">
        <property type="nucleotide sequence ID" value="XM_009545449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFD7"/>
    <dbReference type="FunCoup" id="W4KFD7">
        <property type="interactions" value="321"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KFD7"/>
    <dbReference type="GeneID" id="20675968"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_449612"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102602_3_1_1"/>
    <dbReference type="InParanoid" id="W4KFD7"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF150">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="14">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETW84025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="125" mass="13370" checksum="FC3CC6E9A31C28E1" modified="2014-03-19" version="1">MSAKIVTLDELRQHTTKASMWVLIDGKVYDATNFLDEHPGGDEVILSESGKDGTEAFEDVGHSDEARAMLPGMLVGELEKGSLPNVRSNGSSGAVNSAVQSSSNVAYFIPLAGLVAYFAWRFYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFE4</accession>
    <name>W4KFE4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_242275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543754.1">
        <property type="nucleotide sequence ID" value="XM_009545459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFE4"/>
    <dbReference type="STRING" id="747525.W4KFE4"/>
    <dbReference type="GeneID" id="20668922"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_242275"/>
    <dbReference type="eggNOG" id="KOG0429">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092140_0_0_1"/>
    <dbReference type="InParanoid" id="W4KFE4"/>
    <dbReference type="OrthoDB" id="5596422at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23814">
        <property type="entry name" value="UEV_AKTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="3"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW84035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="205" mass="23402" checksum="A47C0F67FAD0E00B" modified="2014-03-19" version="1" fragment="single">SAVQRAAVAFEYASLRYQAHCPLGMYIIPSLENLSIWDGVLFVHQGYYTDSILKLRLTFPPEYPERAPTVHFITDIFHPLVSQQDGAFNLGAKFRPWRPRENHVYDILHYVKASFKKHALDQFKETDCFNKEAFRSVPYHDSTSSFAALATQSSMLSQTASALFDSDHPTMAAKGPAHGLPFRELRPEQSHALRLKMGLQEWDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFX3</accession>
    <name>W4KFX3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="10">PPIase</shortName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_313566</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543906.1">
        <property type="nucleotide sequence ID" value="XM_009545611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFX3"/>
    <dbReference type="FunCoup" id="W4KFX3">
        <property type="interactions" value="906"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KFX3"/>
    <dbReference type="GeneID" id="20670046"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_313566"/>
    <dbReference type="eggNOG" id="KOG0415">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="6"/>
            <end position="173"/>
        </location>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
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                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">TC 32-1</strain>
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        <property type="entry name" value="NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1"/>
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            <end position="140"/>
        </location>
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        </location>
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        <location>
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            <end position="1841"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="33"/>
        </location>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF11707"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF16201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW84659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2038" mass="228741" checksum="10949FB466660ED8" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4KG55</accession>
    <name>W4KG55_HETIT</name>
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        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_473535</name>
    </gene>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009546141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KG55"/>
    <dbReference type="GeneID" id="20677522"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_473535"/>
    <dbReference type="HOGENOM" id="CLU_074158_0_0_1"/>
    <dbReference type="InParanoid" id="W4KG55"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW84807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="332" mass="36885" checksum="7B81D100487840D1" modified="2014-03-19" version="1">MACIIPTDAQRSTYSALEGAVRPFTGPWAVMARTIAAARLDPRWDPSVWRRETRKREADAEEAPSPKRARMKEDLEGATAGANVVGGKRESEGEEGEMMEMEIGTGAVSEGSGGTWSSESGFRPIPAPGPVGAAGGLHPRLVAVPQVDGSALYQHNHTSTTSTHRVDNPAGEFVIEPVPLPSGGPSISPSAGDQEEAREPIEDGDDEDQLRLGDETTLSQREAAVVIDENIYGGDIMRCVPCNKTFRRKYDRRRHVVTVHYLGKFPCDWCDMYFYTRRDGITRHKKGNCPARDFEDRHTNPWRWFTAWVNGPRRGGRRRWGTVGSKRRRRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGD6</accession>
    <name>W4KGD6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_149291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544525.1">
        <property type="nucleotide sequence ID" value="XM_009546230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGD6"/>
    <dbReference type="GeneID" id="20667336"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_149291"/>
    <dbReference type="HOGENOM" id="CLU_2498135_0_0_1"/>
    <dbReference type="InParanoid" id="W4KGD6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="86" mass="9557" checksum="A7C7DDB9FC2E1E09" modified="2014-03-19" version="1">MVAARPPGRAWCLQSSRATRRARRRRSTPMPRCEPHPRRRVPTAQQRDLRLCAAQSALSLTLMPGNFLAAALISTCGRGLLITHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGI3</accession>
    <name>W4KGI3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_425641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543876.1">
        <property type="nucleotide sequence ID" value="XM_009545581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGI3"/>
    <dbReference type="GeneID" id="20674038"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_425641"/>
    <dbReference type="HOGENOM" id="CLU_1835413_0_0_1"/>
    <dbReference type="InParanoid" id="W4KGI3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW84176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="140" mass="15632" checksum="DC2E75AD6B31E2B6" modified="2014-03-19" version="1">MRVAEGSRGRLKKDPDCILYSWAEEVPLQELLAGSLAFSGALLDGASLAFKTKETTAQFIISWPGFQAKEYPIPNAKRITRAQLAHEFARCFSRYVETTITTPESRPPLGETFLVSFINVTDNGWQADLTEDIEVLRHGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGM2</accession>
    <name>W4KGM2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_439197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544131.1">
        <property type="nucleotide sequence ID" value="XM_009545836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGM2"/>
    <dbReference type="GeneID" id="20675117"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_439197"/>
    <dbReference type="HOGENOM" id="CLU_2223601_0_0_1"/>
    <dbReference type="InParanoid" id="W4KGM2"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="106" mass="10387" checksum="13AE583E77ACE715" modified="2014-03-19" version="1">MDVDTRRPVRRESERDMARLTMWAKDESFSRQAGGSASGAGGAVTGLGRKPAGARGAGAGAGAGGVGRGAAGRSGESGSGGPARGPVRKAASGLSMVADRRGRFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4KH28</accession>
    <name>W4KH28_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_32874</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the lipid remodeling steps of GPI-anchor maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PGAP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009543454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KH28"/>
    <dbReference type="FunCoup" id="W4KH28">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KH28"/>
    <dbReference type="GeneID" id="20671439"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_32874"/>
    <dbReference type="eggNOG" id="KOG2970">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032917_1_1_1"/>
    <dbReference type="InParanoid" id="W4KH28"/>
    <dbReference type="OrthoDB" id="419770at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016482891" description="Post-GPI attachment to proteins factor 3" evidence="7">
        <location>
            <begin position="22"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW85163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="345" mass="39933" checksum="EA1F2A7D85B1AEDB" modified="2014-03-19" version="1">MRSRLFLCFSALALLSNSVLASSGDRANDFQRCAARCESQTCASDIDHTISFLDALTHWTCADQCKYQCMHTITDFAIETGVPVQQYYGKWPFWRFLGMQEPASVLFSLMNLLLHVWGRAEVQRDVPDGHPMKKYYIWWSYVSSNAWIWSAVLHTRDVSLTEKLDYFSAALTILYSLYFSVIRLFHLYPIDPRNRPFSSSTFDTIQRQKLYYFWSVACVFIYLGHVSYLLNLPRFDYTYNIIFNLVLGLSHNFLWLTFAFPSSYSLFRRFTSKPKSYRPAYATTAAKAVVLTTAATCLELFDFAPWHRVVDAHSLWHLATVPLAVIWYDFLILDARDAGWKGIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHI3</accession>
    <name>W4KHI3_HETIT</name>
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        <recommendedName>
            <fullName evidence="5">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_47010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009544903.1"/>
    </dbReference>
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    <dbReference type="STRING" id="747525.W4KHI3"/>
    <dbReference type="GeneID" id="20677329"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_47010"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004854_0_0_1"/>
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    <dbReference type="OrthoDB" id="21225at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000146">
        <property type="entry name" value="Putative two-component response regulator SSK1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="860"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="405"/>
            <end position="465"/>
        </location>
    </feature>
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        <location>
            <begin position="609"/>
            <end position="658"/>
        </location>
    </feature>
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        <location>
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            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="806"/>
            <end position="853"/>
        </location>
    </feature>
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        <location>
            <begin position="932"/>
            <end position="960"/>
        </location>
    </feature>
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        <location>
            <begin position="1032"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="625"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="637"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="815"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="825"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1050"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW84536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1151" mass="122055" checksum="357E40EBBE99AB93" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHS6</accession>
    <name>W4KHS6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_121127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544482.1">
        <property type="nucleotide sequence ID" value="XM_009546187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHS6"/>
    <dbReference type="GeneID" id="20666734"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_121127"/>
    <dbReference type="HOGENOM" id="CLU_1219814_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHS6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="227" mass="26370" checksum="A58BBC2A4A5AB71E" modified="2014-03-19" version="1">MSELKLKVQVSESKIRGGRFGCAMRIRDPRNGSRDRDRKLFIQKCARVWICLVSSEYLLREGNEESNAKHGSILFSARERKDVGYFTFWRVETKKRHITRRLRELDRYTRWKEEKCKQEEKSSAPKRSCTLALCTESEHVDNASGKAANGSTYWNLETVSAPDNPTTIPRTLIDPRQKQKGRKQQECCETEGERERAIDDDDAEAAWGAQGQRWARNKREEKENGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHZ1</accession>
    <name>W4KHZ1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chloroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_115260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542336.1">
        <property type="nucleotide sequence ID" value="XM_009544041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHZ1"/>
    <dbReference type="STRING" id="747525.W4KHZ1"/>
    <dbReference type="GeneID" id="20666471"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_115260"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021989_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHZ1"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053245">
        <property type="entry name" value="MitoProcess-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563:SF1">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="400"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="624" mass="66603" checksum="0C0FF1B170EDFA6F" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIM9</accession>
    <name>W4KIM9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_115217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542411.1">
        <property type="nucleotide sequence ID" value="XM_009544116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIM9"/>
    <dbReference type="GeneID" id="20666469"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_115217"/>
    <dbReference type="HOGENOM" id="CLU_1917315_0_0_1"/>
    <dbReference type="InParanoid" id="W4KIM9"/>
    <dbReference type="OrthoDB" id="3237556at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW85564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="132" mass="14052" checksum="BA40D9DB396880E2" modified="2014-03-19" version="1">MAGSTNGSIAPYTEWNEAVIVAVVFVGLLSVTLLLLLLHACVRSQIRLAKNDAGRDGGDCENTHPDDSMLEEKESGVTPTSQASQTSFTLSPDQPVVFDVDTGRGYNVEIMQVILTPPTPAKERGDKGVPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJ23</accession>
    <name>W4KJ23_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="14">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Exo-1,3-beta-glucanase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HETIRDRAFT_43491</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="14"/>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541783.1">
        <property type="nucleotide sequence ID" value="XM_009543488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJ23"/>
    <dbReference type="FunCoup" id="W4KJ23">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KJ23"/>
    <dbReference type="GeneID" id="20674782"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_43491"/>
    <dbReference type="eggNOG" id="ENOG502QRG8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004624_6_1_1"/>
    <dbReference type="InParanoid" id="W4KJ23"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000033">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="18">
        <location>
            <begin position="197"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="654"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ETW85842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="675" mass="72777" checksum="28BAC3E83F6C05E3" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJX6</accession>
    <name>W4KJX6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dual-specificity kinase</fullName>
            <ecNumber evidence="2">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_379660</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="2"/>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542468.1">
        <property type="nucleotide sequence ID" value="XM_009544173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJX6"/>
    <dbReference type="STRING" id="747525.W4KJX6"/>
    <dbReference type="GeneID" id="20671979"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_379660"/>
    <dbReference type="eggNOG" id="KOG0667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_5_13_1"/>
    <dbReference type="InParanoid" id="W4KJX6"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14210">
        <property type="entry name" value="PKc_DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000087">
        <property type="entry name" value="Dual specificity tyrosine-phosphorylation-regulated kinase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000112">
        <property type="entry name" value="Putative dual specificity tyrosine-phosphorylation-regulated kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.30">
        <property type="entry name" value="DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042521">
        <property type="entry name" value="DYRK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF22">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="139"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="458"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="473"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="511"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW85630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="538" mass="60775" checksum="3DD5B87F0079E1E7" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4KK81</accession>
    <name>W4KK81_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_311400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543008.1">
        <property type="nucleotide sequence ID" value="XM_009544713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KK81"/>
    <dbReference type="GeneID" id="20669867"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_311400"/>
    <dbReference type="eggNOG" id="ENOG502SW28">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127256_0_0_1"/>
    <dbReference type="InParanoid" id="W4KK81"/>
    <dbReference type="OrthoDB" id="3542212at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42052">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42052:SF1">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="18770" checksum="89459023CA9EA36A" modified="2014-03-19" version="1">MPVTEFARLEFVKPNDLFSPHLLPLFTKVSELQAAWSGYPLLFYRNINKEDEYFLISGWRDVPAHEAWMKSEQNQGLLKALGSSVGAIDLIHLDIDYGQMPRDLDTLVLEQSSGESEVGKGTGGDNSDWQAIGKDVEGKRDTIFHFAGYRVGGEIGTHEGSSILSRVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKB3</accession>
    <name>W4KKB3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Isovaleryl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HETIRDRAFT_432635</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542932.1">
        <property type="nucleotide sequence ID" value="XM_009544637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKB3"/>
    <dbReference type="STRING" id="747525.W4KKB3"/>
    <dbReference type="GeneID" id="20674622"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_432635"/>
    <dbReference type="eggNOG" id="KOG0141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_1_1"/>
    <dbReference type="InParanoid" id="W4KKB3"/>
    <dbReference type="OrthoDB" id="9988775at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008470">
        <property type="term" value="F:3-methylbutanoyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01156">
        <property type="entry name" value="IVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000007">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000003">
        <property type="entry name" value="isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000004">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034183">
        <property type="entry name" value="IVD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF18">
        <property type="entry name" value="ISOVALERYL-COENZYME A DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 12" id="KW-0274">FAD</keyword>
    <keyword evidence="4 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="15">
        <location>
            <begin position="53"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="14">
        <location>
            <begin position="170"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="13">
        <location>
            <begin position="276"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="203"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="287"/>
            <end position="290"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="383"/>
            <end position="387"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="410"/>
            <end position="411"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="412"/>
            <end position="414"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETW86164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="46993" checksum="59F1BEF4F3CD3488" modified="2014-03-19" version="1">MQGPPECGPQQMALTSPLQFASRSASRLRRIAFSASPRRRHASTYNADVAGLTEEQAEFRHSVAQFAKKEVEHRAAEIDKSNTFPMDLWPKLGQMGLLGVTCSSKYGGLEQGYFEHTLAMEELSRASGSVALSYGAHSNLCVNQIHRHGTEAQKEKYLPDLISGKKVGSLAMSEPNSGSDVVSMGLKAVKKSGGWVLNGNKFWITNGPTASTLVVYAKTSPEKGSQGITAFIIENDFPGFSTHQKLDKVGMRGSDTCELVFEDCEVPDENVLGQVDKGAAVLMSGLDLERLVLSGGPLGLMQAAFDYAIDYVHERKQFGRAIGTFQLMQGKIADMYTKINASRSYVYSVARACDRGQISRRDCAGAILYSTEKAVEVALEGMQCLGGNGYINDFPMGRIMRDSRLYTVGAGTQEIRRMLIGREFNQDYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKC2</accession>
    <name>W4KKC2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_425132</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542941.1">
        <property type="nucleotide sequence ID" value="XM_009544646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKC2"/>
    <dbReference type="STRING" id="747525.W4KKC2"/>
    <dbReference type="GeneID" id="20674020"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_425132"/>
    <dbReference type="eggNOG" id="KOG3904">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018689_0_0_1"/>
    <dbReference type="InParanoid" id="W4KKC2"/>
    <dbReference type="OrthoDB" id="1695362at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18870">
        <property type="entry name" value="NUDIX_AcylCoAdiphos_Nudt19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039121">
        <property type="entry name" value="NUDT19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE NUDT19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318">
        <property type="entry name" value="TESTOSTERONE-REGULATED PROTEIN RP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="11"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW86174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="306" mass="33999" checksum="8BD3965847BF68F5" modified="2014-03-19" version="1">MTGIASVHPSAPRPSASLIVVNARNEILFVHRNPQAQSFGGVHVFPGGNYDAAQDDSYQMTAIRETFEESGVLLASSRTQTTLLSDAVVDSSRRSIHAQQMLFKDFLKEHNLETDRKYLLPFTEWVTPPQVPRRFHTRFYVAFLPSSSTTTSDFSHGTIQHRLPTSDGGLEVIAARFIHPLDALAEFRSSKIALMPPQYYLITTLAGVLHGREATLEQQARVRELAAGAFGSMVINPRGHPGGQDQDGRSVLTYEGDETRGGSKGRLHRSLVRFGKKGIPTEIVLLRNFDVFTEIEHQAFSKQSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKT8</accession>
    <name>W4KKT8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_377052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540459.1">
        <property type="nucleotide sequence ID" value="XM_009542164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKT8"/>
    <dbReference type="GeneID" id="20671866"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_377052"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_6_1_1"/>
    <dbReference type="InParanoid" id="W4KKT8"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF7">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW86437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="578" mass="65741" checksum="05941FEA0AE0FE88" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKU7</accession>
    <name>W4KKU7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_308358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540497.1">
        <property type="nucleotide sequence ID" value="XM_009542202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKU7"/>
    <dbReference type="GeneID" id="20669575"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_308358"/>
    <dbReference type="HOGENOM" id="CLU_112288_0_0_1"/>
    <dbReference type="InParanoid" id="W4KKU7"/>
    <dbReference type="OrthoDB" id="3133596at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="28784" checksum="B712C416B6A1E0D0" modified="2014-03-19" version="1" fragment="single">AISNIKHCLVTNELASEARVEPCYLLNQRLWDNKEMLTRLEWHWGMKYSSLELNVEANMIYLRQDLLESFDSNRWLLLPPPEMVDRVWARYFMIDLKSPIQQSPIESIYEGGEVFEYRLFPLDKDLRPIKRFDEPDSTNRSSPLNADPTEENSTRHSYPFDSLPILVSSVRPHFVILDSAGKLFNQPWIVSTVVPSLWPISEYDASHMLWHLEFVFGLKLRRPLDLRLRRALLCGRLLSTRVHVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKV5</accession>
    <name>W4KKV5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">H/ACA ribonucleoprotein complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Nucleolar protein family A member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_414960</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the U3 snoRNP particle. Binds to the C'/D and B/C motifs in U3 snoRNA. Component of the 25S U4/U6.U5 tri-snRNP particle, a subcomplex of the spliceosome. Binds to the 5' stem-loop of U4 snRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542779.1">
        <property type="nucleotide sequence ID" value="XM_009544484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKV5"/>
    <dbReference type="FunCoup" id="W4KKV5">
        <property type="interactions" value="623"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KKV5"/>
    <dbReference type="GeneID" id="20673211"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_414960"/>
    <dbReference type="eggNOG" id="KOG3387">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084513_4_1_1"/>
    <dbReference type="InParanoid" id="W4KKV5"/>
    <dbReference type="OrthoDB" id="1924699at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000002">
        <property type="entry name" value="NHP2-like protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="12">
        <location>
            <begin position="21"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW85985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="128" mass="14107" checksum="373ED430128D9905" modified="2014-03-19" version="1">MSDPQTRGKAWPLAPADLNNQILDLVQQAATYKQLKKGANEATKTLNRGIAEFIILTADTEPLEILLHLPLLCEEKNVPYIFIESKAALGRACGVTRPVIAASVTTNEQRELQSQIQIVKKAIDKLMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMG8</accession>
    <name>W4KMG8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_423983</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540961.1">
        <property type="nucleotide sequence ID" value="XM_009542666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMG8"/>
    <dbReference type="GeneID" id="20673947"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_423983"/>
    <dbReference type="HOGENOM" id="CLU_365255_0_0_1"/>
    <dbReference type="InParanoid" id="W4KMG8"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050460">
        <property type="entry name" value="Distal-less_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24327:SF41">
        <property type="entry name" value="BRAIN-SPECIFIC HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24327">
        <property type="entry name" value="HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="355"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="357"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="144"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="287"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="412"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="555"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="445"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="572"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW87007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="764" mass="83812" checksum="CDD3DD4DBC3EFBAB" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMM0</accession>
    <name>W4KMM0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">serine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_413413</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541013.1">
        <property type="nucleotide sequence ID" value="XM_009542718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMM0"/>
    <dbReference type="FunCoup" id="W4KMM0">
        <property type="interactions" value="298"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KMM0"/>
    <dbReference type="GeneID" id="20673108"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_413413"/>
    <dbReference type="eggNOG" id="KOG2509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023797_4_3_1"/>
    <dbReference type="InParanoid" id="W4KMM0"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="230"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="318"/>
            <end position="320"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="334"/>
            <end position="337"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="405"/>
            <end position="408"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="8">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW87067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="500" mass="54975" checksum="29633946C51CDC7E" modified="2014-03-19" version="1">MASCVRCGFQFVSQIRALPRFGSRIRHYSTKDDLSRSNLPKPRLDYRSISENVVYKSHNAFNRKAPLPIGSVQSIERLYKQQKELQHSFNSKKHEQSQIGELVRTAAKDTEARTAAVQKAKSLKNDIAALQAQLHEVADKLLSLALAIPNDTHPESPLGSETEAVTLSTHGPSPMPASSDRDHVAIGRALGLFDLEAGASVTGSSWYYLLNEGALLEMALVNYALSVAIKHGFTPVTTPDVVRSDIASRCGFQPRDQAVDPPVSQMYHLSGTETSSSPHPELILAGTAEIPLAGLFANKVFLENELPRKVVGLGRAFRAEAGARGADTRGLYRVHQFTKLELFVVSESDKSEEMMEDMRKIQVEIFDGLGLPIRVLDMPTEELGASAYRKYDMEAWMPGRGSWGEISSTSNCTDYQSRRLHIRYRPIASPSSTSTSATQHSSLPFAHTLNGTAAAVPRLIVALLENGARFDEQGKVIGLRLPATLKPFWLGAARDIIKWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KN29</accession>
    <name>W4KN29_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_243105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541152.1">
        <property type="nucleotide sequence ID" value="XM_009542857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KN29"/>
    <dbReference type="GeneID" id="20668962"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_243105"/>
    <dbReference type="eggNOG" id="ENOG502S5M9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073624_1_1_1"/>
    <dbReference type="InParanoid" id="W4KN29"/>
    <dbReference type="OrthoDB" id="2142503at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36854">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36854:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="125" mass="13733" checksum="7BD0E25381FF9B67" modified="2014-03-19" version="1" fragment="single">NKWEATSFCKCVCFGANYSILHMDIPDDPSKPCLSCTKQWCLNQNLPVCAGASLGDTDPDTATGKEGDVEARCFQRDSPRDQLVVTLFLLTVFGLLLGAGIKGRMQKAGIDTSLSWSTGRKWWQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNM6</accession>
    <name>W4KNM6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SH3-domain-containing membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_58635</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SHO1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="ETW86656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540374.1">
        <property type="nucleotide sequence ID" value="XM_009542079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNM6"/>
    <dbReference type="STRING" id="747525.W4KNM6"/>
    <dbReference type="GeneID" id="20678440"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_58635"/>
    <dbReference type="eggNOG" id="ENOG502QW7A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043316_0_0_1"/>
    <dbReference type="InParanoid" id="W4KNM6"/>
    <dbReference type="OrthoDB" id="5983572at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007232">
        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11855">
        <property type="entry name" value="SH3_Sho1p"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="High osmolarity signaling protein SHO1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035522">
        <property type="entry name" value="Sho1_SH3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
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        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="276"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="194"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW86656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="335" mass="34750" checksum="A0940A77D818F210" modified="2014-03-19" version="1">MPPRGNEGLDFTPILTHYLFLFTSILAVVGWFVAFISQAVVTAQFGHGAVGTLWFAIFLELFLVVGVLYTLASDSIAMHRFQISTFGAVAIVFSVLGVDAGIFTGQAARGAMAAGWLILAVVNILWVLYFTSEEDSLTLHVFNALGTGGLTPPSRRRRTRTQSVHNMGAGNGYGGGYSSPAGVGSAPYDTKMTTNFSPGAGIRSQGSLHGSSGVDGGPPKSLNGAPSIASNMAPGASSMPGENGGVTSPLTTPGNAGVGSGGGPPLPEDTSINSEGYAYKAKALYAYSASPDDPNEISFAKGEIMDIMDKQGKWWQAKKADGSIGIAPSNYLQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNW5</accession>
    <name>W4KNW5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription initiation factor TFIID subunit 1 histone acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_468878</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="ETW87080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009542729.1"/>
    </dbReference>
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    <dbReference type="STRING" id="747525.W4KNW5"/>
    <dbReference type="GeneID" id="20677259"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_468878"/>
    <dbReference type="eggNOG" id="KOG0008">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000572_0_0_1"/>
    <dbReference type="InParanoid" id="W4KNW5"/>
    <dbReference type="OrthoDB" id="5752at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 1 histone acetyltransferase" evidence="4">
        <location>
            <begin position="319"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="57"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="652"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="652"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW87080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="706" mass="80479" checksum="8A5F9A3CE3BCAFEF" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNY7</accession>
    <name>W4KNY7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_468407</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540745.1">
        <property type="nucleotide sequence ID" value="XM_009542450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNY7"/>
    <dbReference type="STRING" id="747525.W4KNY7"/>
    <dbReference type="GeneID" id="20677231"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_468407"/>
    <dbReference type="eggNOG" id="KOG0895">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="47801at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23810">
        <property type="entry name" value="UBCc_BIRC6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
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    </dbReference>
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        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UQ_con"/>
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        <property type="entry name" value="UBC_2"/>
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        </location>
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        </location>
    </feature>
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            <begin position="162"/>
            <end position="200"/>
        </location>
    </feature>
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        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW86756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="769" mass="84782" checksum="0862B006C1CF8F39" modified="2014-03-19" version="1"> </sequence>
</entry>
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    <accession>W4KQD4</accession>
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        <recommendedName>
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        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">HETIRDRAFT_306489</name>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="20669409"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_306489"/>
    <dbReference type="eggNOG" id="ENOG502S83X">
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
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        <property type="entry name" value="NAT_camello-type"/>
    </dbReference>
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        <property type="entry name" value="GNAT FAMILY N-ACETYLTRANSFERASE"/>
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    </dbReference>
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        <property type="entry name" value="LD18367P"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW87261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="35333" checksum="564E66C930B3335A" modified="2014-03-19" version="1">MSTNHSEAIQARIRPYQPRDEKQVRFMVGQAQMEPLAFANNRGQCEQTSFAAPTDAKNRPAAYFHPVTLAIWIAVSSIFAQFMKWWPDPSNGFWGYIFVLPAFFTPAVPIMFFIDWINRPDVEETAEKVLRRPDLYDISAYYSRSPASGFWILEYSDRIIGLIAVDASLDATLDEPVAQPVSEQQIKKLLHGKGTAPVAVIRHFFIEEAYRPADVEEDLLRYAVGAAFEAKQEVSEVRALGSPLRPSVEKSLCASGFTRKERVRTTGILRWDTNWYTLERKQWQAQEEVGARSVVVEDTKHKTVIATTETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4JN21</accession>
    <name>W4JN21_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_332573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Schmutz J."/>
                <person name="Solheim H."/>
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                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009555043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JN21"/>
    <dbReference type="STRING" id="747525.W4JN21"/>
    <dbReference type="MEROPS" id="M38.979"/>
    <dbReference type="GeneID" id="20671745"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_332573"/>
    <dbReference type="eggNOG" id="KOG3892">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032482_3_2_1"/>
    <dbReference type="InParanoid" id="W4JN21"/>
    <dbReference type="OrthoDB" id="10264777at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="77"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW74869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="134" mass="14893" checksum="BB6538967BBF2151" modified="2014-03-19" version="1" fragment="single">LEYNVFSEGCILITAMKILDPHPRDGVHEWREGKHFVKEGDRLYLEGTDTSPAGKPKPLSRDLFITATYLYVRSVVTLDKCVHNFARFTGCSLDEALKCATLNPARCLGIENKKGTLRPGADADLVVLDRMGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4JP20</accession>
    <name>W4JP20_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_482614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553291.1">
        <property type="nucleotide sequence ID" value="XM_009554996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JP20"/>
    <dbReference type="STRING" id="747525.W4JP20"/>
    <dbReference type="GeneID" id="20678040"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_482614"/>
    <dbReference type="eggNOG" id="ENOG502SAMB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037980_2_0_1"/>
    <dbReference type="InParanoid" id="W4JP20"/>
    <dbReference type="OrthoDB" id="5570013at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW74815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="487" mass="53158" checksum="998769C7A237E022" modified="2014-03-19" version="1">MIIVDTAPLRKGNPPDDAEAAEAAAQPPPPAYSGYQPAQNYPSTTQIYVIPAQASRVSTTRRFFKAFLVAALIWALTGIFVRSFVELVAYSHHRRPYPGAYQNGPNWEGGHWPPPPRLPMHPHERPVKCVHGPEWTPIGAAPGTYPRQFIANTQLDLPFDSDTLFLLSRGSLSHGIVRIIEDDHVGAGDKVQVSIEVRYYSQEALSRANVCSLTRGHRENGIGIFTSDHRENRREQQLQFDVTVRLPSDAETLYIPAFETDLKLFAHYLGPLASAYTFGSVLLKTSNFPIDVQSIDAYRAKISTENAAIRGSFNVSTSLELATSNAPIEADVSLYNSQSNHATSLRLATRNGPIKAALRLYTDSLRSSFKVDATTSNSPLTITNNVSPPDSILRLSAETSNSPAHVLLASAYEGTFSVGTSLFSPVVDRNTRKEDPSGRGRERSVNVRNVRGGVVEGAVSWEPSELPRGGAGEVSLRTSNSPVTLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4JP78</accession>
    <name>W4JP78_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_144787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553187.1">
        <property type="nucleotide sequence ID" value="XM_009554892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JP78"/>
    <dbReference type="GeneID" id="20667050"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_144787"/>
    <dbReference type="eggNOG" id="ENOG502SWNN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1763172_0_0_1"/>
    <dbReference type="InParanoid" id="W4JP78"/>
    <dbReference type="OrthoDB" id="3270241at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW74696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="148" mass="16142" checksum="15859FA206EB4D76" modified="2014-03-19" version="1" fragment="single">MSPSFFCRWDWCRCTFPTYKGLADHVVGEHIEQAQPVPRQDIELLCRVESANGAIDSISTDIFTQSDAHLTLSSRSQNGLFPSEGAADPHPRSLRLPSRHDATMKASAPSLVSNPSPPTPPRIATPVQHASSYSPYPVTPQRSGFSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPC1</accession>
    <name>W4JPC1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_456000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552801.1">
        <property type="nucleotide sequence ID" value="XM_009554506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPC1"/>
    <dbReference type="STRING" id="747525.W4JPC1"/>
    <dbReference type="GeneID" id="20676686"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_456000"/>
    <dbReference type="HOGENOM" id="CLU_2121394_0_0_1"/>
    <dbReference type="InParanoid" id="W4JPC1"/>
    <dbReference type="OrthoDB" id="3357985at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW75378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="114" mass="12910" checksum="D86A5BFCE0DC83AF" modified="2014-03-19" version="1">MAYLTSSFTDVDNSYRKICTNVESRDVGVWSPSEVQPRLDMTALALQNTRPVVDAQFPFDEPHADVILRSSDNTDFRVYENILSLASPFFRELFSLPQPPDEPYTGSAKNMSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPN9</accession>
    <name>W4JPN9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_412751</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553306.1">
        <property type="nucleotide sequence ID" value="XM_009555011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPN9"/>
    <dbReference type="GeneID" id="20673064"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_412751"/>
    <dbReference type="HOGENOM" id="CLU_2904454_0_0_1"/>
    <dbReference type="InParanoid" id="W4JPN9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW74831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="62" mass="6891" checksum="77369E51CE86AE1B" modified="2014-03-19" version="1">MDRTFIAIHRIACYAPIIDATNLGLAAPSRLPRITGQVHSPHFVSCSRDLLSFKSQLYLPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPQ1</accession>
    <name>W4JPQ1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_430866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_430866"/>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <end position="167"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="186" mass="20561" checksum="F3211AF736B318C9" modified="2014-03-19" version="1">MHPTNASTTRNTYQPSGRVKSAPAIFSAASTSVSGTRRRVGQDRVPREGAGPAAGGACRHGGTRASRLRLDDALRPRRGLRFWVGGTRDERGHRALRALDARPIPLPLACQNTEHIISRVSRKSDDEAIDGELPSYVVDCSTATPRTPKERKSQNRERRDRRCRNDDTHTCKGEVVAVQRRIEISS</sequence>
</entry>
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    </protein>
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            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="20672483"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_391677"/>
    <dbReference type="HOGENOM" id="CLU_819055_0_0_1"/>
    <dbReference type="InParanoid" id="W4JQ34"/>
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    </dbReference>
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            <begin position="94"/>
            <end position="209"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="302"/>
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        </location>
    </feature>
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            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW74991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="339" mass="37854" checksum="631F72A659E7BE5F" modified="2014-03-19" version="1">MGFDAGTIQYDLSIEWTTAKTFPRDMAAQLMTALCWRLPLQNVQRLCIKGRYSVSPLRWFSTFRHLKDVTTVIAAGDVIYGFINALPVLKDVTENTESDEESESEAVEETAEEGNKKKVEDTVEDTVEKTGEDTGEKTEEDTVKKTGEETGEDAVKKTVEETIEDESKESSNTEKVTEPDAHHDTETIKDKGKGKEVERETDVAPPPKMKLFPKLSDLSLDYAQLDKATGRPYIETLKSALEIRTDISQSPFALAFRACAVSKRSLHLLNDIELVEVENNVADLFSPEGMFGEEKWALGPSEEPESYDDVDGDLLRPEEEEEARKGEDKEGSEGAQQES</sequence>
</entry>
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    <accession>W4JQK2</accession>
    <name>W4JQK2_HETIT</name>
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        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 18 protein</fullName>
        </submittedName>
    </protein>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="747525.W4JQK2"/>
    <dbReference type="GeneID" id="20672000"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_38004"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_002833_6_1_1"/>
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    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:chitinase activity"/>
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        <property type="term" value="P:carbohydrate metabolic process"/>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
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    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
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    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
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        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844901" evidence="2">
        <location>
            <begin position="17"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="3">
        <location>
            <begin position="57"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW75803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="445" mass="46117" checksum="C7667BE40B674DE9" modified="2014-03-19" version="1">MLLLLPVLLSVSMVWAAPYCSLAPAAPSGSTATSAGGSGGHSSNGTGSGSSGSPGSVVAATWWASWHSSDFPLSSISWSKYSSVIYAFGVTTPDAGTVGLQSSDEQLIPQFVQLAHQNNVNAILSIGGWTGSQYFSTAVSTDSNRTAFAQAVMKVVSQYNLDGIEFDWEYPNHQGIGCNTLSPDDSANFLTFLQTLRSQDGASNLILSAAVAVTPFVGSDGAPMSDVSGFAKVLNYIEVMNYDIWGSWSPEVGPNAPLNDSCTPSGIAPEGSAVSAVNSWTKAGFPAEQIIMGVASYGHSFHVATSSALDSSGSLAAYPPFDKSQQPHGDSWDSDGTGPADQCGNPPAIGGVFDFWGLIQGGFLNANGTAESGIEYRFDNCSQTPYVYNPNTQVMVSYDDATSFAAKGTFISQSGLAGFAMWEAGGDSNNILLNAISTALGCGDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRN5</accession>
    <name>W4JRN5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_455758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552442.1">
        <property type="nucleotide sequence ID" value="XM_009554147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRN5"/>
    <dbReference type="GeneID" id="20676662"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_455758"/>
    <dbReference type="HOGENOM" id="CLU_1415329_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRN5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="192" mass="21773" checksum="3B414C4D11DC7591" modified="2014-03-19" version="1">MHAEPRWDHLALSGRTRDPPPVPVSPRARLDDRRYQQQQQPRLRLSATLRRDETDRSSTRRRTPHAARWSAASASKGRHRSSSHQIERRARDARVFGARTSANLSATRQPNDGRAAHGPQRDLTLHEHSFPQEEPVTRDRKKNAPPVPPPRRRANTISPRARHPFPHTPRLGSAQLGSAHDEQAPPLLTPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRN9</accession>
    <name>W4JRN9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_422768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552411.1">
        <property type="nucleotide sequence ID" value="XM_009554116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRN9"/>
    <dbReference type="GeneID" id="20673848"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_422768"/>
    <dbReference type="HOGENOM" id="CLU_2671368_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRN9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="75" mass="8459" checksum="E2D782BECC017C79" modified="2014-03-19" version="1">MFFTFFIPNHRPFDVGKPDVALFFWITFCIKETTISPPRSLTLVILAVVVRATSSPLPSWALCGRMLFVTGPSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JS15</accession>
    <name>W4JS15_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_163019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552460.1">
        <property type="nucleotide sequence ID" value="XM_009554165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JS15"/>
    <dbReference type="GeneID" id="20667817"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_163019"/>
    <dbReference type="eggNOG" id="ENOG502R1MW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097242_0_0_1"/>
    <dbReference type="InParanoid" id="W4JS15"/>
    <dbReference type="OrthoDB" id="2804369at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="217" mass="24785" checksum="12154001664AFE55" modified="2014-03-19" version="1">MPAVNVNTVSPELELPVPFAPTQRKLTSEDYLRVFQYTPFNYLPKQLIPLRSHSMRAPLMHCGWTMDRLWKYAEDNGFVHSTATETFTEDELASAEFPPISESFVIDEGQCMSNALEDIGAKHGIKDILEFTEIERVVRDGKGGFISLYTNYTRKRAPPAEFVEKLRVALGEEEGPKWYLDSFRCYWEPKPELLFGGQSRKSATTPARSKFAKSRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSD7</accession>
    <name>W4JSD7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_421922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551360.1">
        <property type="nucleotide sequence ID" value="XM_009553065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSD7"/>
    <dbReference type="GeneID" id="20673762"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_421922"/>
    <dbReference type="HOGENOM" id="CLU_187838_0_0_1"/>
    <dbReference type="InParanoid" id="W4JSD7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="91" mass="10150" checksum="5595CD6014373390" modified="2014-03-19" version="1">MAMLFTEIIKPRSSTEQVVDEHAPALGSEGGIREAFGRYRTALDKYQRCRLAPNMVGPCPTNDKPPKDVRQHLGQFAHTSRTHHGHTGVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSP1</accession>
    <name>W4JSP1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_455110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551470.1">
        <property type="nucleotide sequence ID" value="XM_009553175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSP1"/>
    <dbReference type="GeneID" id="20676586"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_455110"/>
    <dbReference type="HOGENOM" id="CLU_1959861_0_0_1"/>
    <dbReference type="InParanoid" id="W4JSP1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="128" mass="13517" checksum="F8AC7131BAACD8EB" modified="2014-03-19" version="1">MWVQGSPPHVNIQPTSAPPFAHATPPLAYSRCIACHYRSIPRTLASSISEAPTTRRSTGVLSSVHPLCIPVRLQVSAERAQRTGGAGSDRRTLVTCQPASAPISDAHPPTCSGGNIPAIPCPSHPRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSX9</accession>
    <name>W4JSX9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_461161</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552418.1">
        <property type="nucleotide sequence ID" value="XM_009554123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSX9"/>
    <dbReference type="GeneID" id="20677145"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_461161"/>
    <dbReference type="eggNOG" id="KOG3855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_20_3_1"/>
    <dbReference type="InParanoid" id="W4JSX9"/>
    <dbReference type="OrthoDB" id="2690153at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="31"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW76210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="548" mass="59603" checksum="DB5024CAD9ED115C" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTF0</accession>
    <name>W4JTF0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_455718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552387.1">
        <property type="nucleotide sequence ID" value="XM_009554092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTF0"/>
    <dbReference type="GeneID" id="20676655"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_455718"/>
    <dbReference type="eggNOG" id="ENOG502S952">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1627280_0_0_1"/>
    <dbReference type="InParanoid" id="W4JTF0"/>
    <dbReference type="OrthoDB" id="2588098at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="18524" checksum="F22405DAC772AA4E" modified="2014-03-19" version="1">MGQYGDIASLDRRQKEELGKLGLGIKVSQTPIRYFTLLPTELVDIIYTYLPGHISVIFFALTSRRHWQIGRPHIRSRVLALTTWAGDRIICVGDSCWGNDVPPGLELTSAEETELREGRTRRDVTEGFWSDDDDDDFEDTECSTLFDLVDRFRSSVDVLKVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTF9</accession>
    <name>W4JTF9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycoside hydrolase family 28 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_174466</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551306.1">
        <property type="nucleotide sequence ID" value="XM_009553011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTF9"/>
    <dbReference type="STRING" id="747525.W4JTF9"/>
    <dbReference type="GeneID" id="20668513"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_174466"/>
    <dbReference type="eggNOG" id="ENOG502QRJW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016031_1_1_1"/>
    <dbReference type="InParanoid" id="W4JTF9"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF8">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW76390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="397" mass="42366" checksum="9DC497D641516D31" modified="2014-03-19" version="1">MWTRAGRVEKKGHICTVIPSHDGGDDSAAIISAFEQCSVDASVVFLNTTYHIERVMKTTGLRNVKVDLGGTLLWGTDIAYWTNHSLPLGYQNQSLAWEFGGDNILFTGNGHGTFDGNGQIWYDYGNGVSNVAGRPINFVIRDTTNSVFEGIRFVQSQFWTMAIHTAENLLLENLYINSTSSTSAPTINTDGVDTFYANNITMRNWEVTCGDDNIALKANSSNILVQDSVFHGGNGVAIGSIGQYPGVYEFIANFTAERVTAIGSTYAGYVKTWTGVEQNFPPNGGGGGLGYAKNITFRDFTVTDLAQNVALITQCTSYSGATGECDTSMFQISDVVWGPIRGTLATDSVAAFQCSGAAPCPGIALVGVDVATPNSSAQSVVCSNVVDPVGFECSTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTQ1</accession>
    <name>W4JTQ1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_422196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551688.1">
        <property type="nucleotide sequence ID" value="XM_009553393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTQ1"/>
    <dbReference type="GeneID" id="20673786"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_422196"/>
    <dbReference type="eggNOG" id="ENOG502S8UP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052543_2_1_1"/>
    <dbReference type="InParanoid" id="W4JTQ1"/>
    <dbReference type="OrthoDB" id="2858653at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42057">
        <property type="entry name" value="F-BOX DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42057:SF2">
        <property type="entry name" value="F-BOX DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00200)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="43963" checksum="1670B2D35DBC7454" modified="2014-03-19" version="1">MNLLPAELLQAVINEISSPGDILNVRLVNKTLCVLATPRAFQRAPVKNTMRSAQGFHALLSSQKIARHITEVAFRDVRESARETGVRELGPSKLKPDGERAIRDTLASAFSKLHELPKLETLTITFSPHVRSSLSSTFLERPLSSLTQMAILRAFTSLAHPLSLKSLTIDNLIASHSDIHDHPAFIATFNKLAYLRITILSDIGTYVGTLYQETLSNFWSTTMQRRILAPSSASYLTCLSLHSDHEFGILPQFTFSELYYPLLDTLSVRGAFFANSVGIEDFIVRHRGTLRSLELRFCKIYCDDDVPDRFWSQVWNRFAKELDRLTVFKAEEEMDMVEMPGYMIRYAYFDAGVGYIPIFNIVPADDVALVTLKVVVASRSNTYRQPAMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4JU98</accession>
    <name>W4JU98_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_221042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550672.1">
        <property type="nucleotide sequence ID" value="XM_009552377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JU98"/>
    <dbReference type="GeneID" id="20668655"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_221042"/>
    <dbReference type="eggNOG" id="ENOG502SRIE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_992279_0_0_1"/>
    <dbReference type="InParanoid" id="W4JU98"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW77127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="281" mass="31753" checksum="09EA2E3DFDE2E79F" modified="2014-03-19" version="1" fragment="single">AEREERQTVIDSFNTQETSADRSLFGDADIVPEHLSHHHYLDLESSPSLSPPPDSTFFLTPPSSPNRSLLPLISPILNLALLEQSPPSPSPSLHDSISPLIPRSPVFWTPTIRPTSLERSFEPATPSPITLANNTFSPTFDFLTMATPSMPARGDRTAPTFDPHQPRELRRYFADLDFHFVRSAVADEQERKKHACRFLDVDTCELWESLTTFTDATKTFKEFGEEVYRLYPGSEEERKWSVSDMDKLVGETSRVGILSLSELGDYHRRFLAITVFLLSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUC7</accession>
    <name>W4JUC7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_327390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ETW77069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="83" mass="9641" checksum="6E8997F18B5ACFA7" modified="2014-03-19" version="1" fragment="single">WTTIYEEAFQILKKTFIESLVFVMLDTKEPFHIEYNASDSTTGAVLSQVTSNRRWHPCTYISKSLSIIECNYSIYNKELLAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUR9</accession>
    <name>W4JUR9_HETIT</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">HETIRDRAFT_455157</name>
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    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009553236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUR9"/>
    <dbReference type="STRING" id="747525.W4JUR9"/>
    <dbReference type="GeneID" id="20676596"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_455157"/>
    <dbReference type="eggNOG" id="ENOG502RSF0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021534_1_0_1"/>
    <dbReference type="InParanoid" id="W4JUR9"/>
    <dbReference type="OrthoDB" id="3248909at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF3">
        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="629"/>
            <end position="684"/>
        </location>
    </feature>
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        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW76646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="684" mass="74507" checksum="9B5B1825A4226E75" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVD2</accession>
    <name>W4JVD2_HETIT</name>
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        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_328020</name>
    </gene>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
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                <person name="Rouze P."/>
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                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
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                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS1 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_328020"/>
    <dbReference type="eggNOG" id="KOG4112">
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    <dbReference type="OrthoDB" id="263893at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009542">
        <property type="entry name" value="Spc1/SPCS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 12 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06645">
        <property type="entry name" value="SPC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
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    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW76811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="85" mass="9479" checksum="A881CAAC6C51C266" modified="2014-03-19" version="1">MLSLSFRCLQDFEGQRAVERISRNGLLALTAVSYVLGLALQSLRVTFGVFGLGIAVLLLVAVPQWPAYNKHPVRWLPKVEAKKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVX3</accession>
    <name>W4JVX3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_327788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551103.1">
        <property type="nucleotide sequence ID" value="XM_009552808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JVX3"/>
    <dbReference type="GeneID" id="20671358"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_327788"/>
    <dbReference type="HOGENOM" id="CLU_052397_0_0_1"/>
    <dbReference type="InParanoid" id="W4JVX3"/>
    <dbReference type="OrthoDB" id="3893071at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="320" mass="36234" checksum="8B565A57A3D1EE94" modified="2014-03-19" version="1">MSDPPWIPWAGHPFDYWVGTNDPDEPVRPCDDLGDIILRASDNLDFVVHQSILSRASPFFKNMFSSNLTDSSLDLQRLDLPVIVMAENQHTLDMFLRLLYPMAQQTVDGITDVTTILQVLDKYEIDSLPAALEASLMRIAEEKPDFVCAVACHFKLPKLANAAAQLLLQHPVVSISSLSTGLVENYEVSSAVRKSHFEYRAHCTLTAIELLEHYKPYCASYKQGFLGSYYVAACNCVREGHSRYRNDSRYSVIWVLDYLDRCRIALEQTPYWKIVLDPSIIIPSVIKAMKCKVCKHNAETMGQLSQELAEKIRSSVARVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWQ1</accession>
    <name>W4JWQ1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C-CAP/cofactor C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_65567</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBCC family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550525.1">
        <property type="nucleotide sequence ID" value="XM_009552230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWQ1"/>
    <dbReference type="FunCoup" id="W4JWQ1">
        <property type="interactions" value="291"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JWQ1"/>
    <dbReference type="GeneID" id="20678742"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_65567"/>
    <dbReference type="eggNOG" id="KOG2512">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032612_0_0_1"/>
    <dbReference type="InParanoid" id="W4JWQ1"/>
    <dbReference type="OrthoDB" id="194775at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1250">
        <property type="entry name" value="Tubulin Binding Cofactor C, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027684">
        <property type="entry name" value="TBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031925">
        <property type="entry name" value="TBCC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038397">
        <property type="entry name" value="TBCC_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139">
        <property type="entry name" value="TUBULIN FOLDING COFACTOR C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16752">
        <property type="entry name" value="TBCC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="7">
        <location>
            <begin position="105"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW77286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="326" mass="35887" checksum="958EAB560B165592" modified="2014-03-19" version="1">MTDTNRTLAQEFYSQFQATRTTLTNRLETAKSTPSSDVVQSLSQEIAQLRKGLVDNTSLLPPYDRRQCEAQMAGLEGMLDQIRTTSTSKPKFAFKRKPASKPNPPPTAGPSTSATTPSVPARPLPSTYLTLSSKSHEHLTLESLPSLVEPSNTPQSDLTIADLDHCVVDLCTPKKPVEPAALGMTFTALHIRDIRDTILLLPSIKGSVLLHNATRCIIAVGCHQFRMHTSNDVDVYLSIPSNPIIEHCARIAFASYPTHLSILTGLPSHPHAMIVKDFSHIRPTPSPNWVAMSGDRRIQDWADVISYSRTNVDLTLEKYIPKSAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWR7</accession>
    <name>W4JWR7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase family 90 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_51948</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550481.1">
        <property type="nucleotide sequence ID" value="XM_009552186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWR7"/>
    <dbReference type="STRING" id="747525.W4JWR7"/>
    <dbReference type="GeneID" id="20678197"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_51948"/>
    <dbReference type="eggNOG" id="KOG2458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005027_4_0_1"/>
    <dbReference type="InParanoid" id="W4JWR7"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF35">
        <property type="entry name" value="PROTEIN O-GLUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="3">
        <location>
            <begin position="271"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW77535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="606" mass="69032" checksum="EF854615FA00364A" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4JX27</accession>
    <name>W4JX27_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_324871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550109.1">
        <property type="nucleotide sequence ID" value="XM_009551814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JX27"/>
    <dbReference type="GeneID" id="20671091"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_324871"/>
    <dbReference type="eggNOG" id="ENOG502SPX6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052689_1_0_1"/>
    <dbReference type="InParanoid" id="W4JX27"/>
    <dbReference type="OrthoDB" id="3256525at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="439" mass="49552" checksum="2A6B9D3E330A5DFE" modified="2014-03-19" version="1">MLSESANEGIPICLPALPNELWLRIFELATEIFGILDPGVHDPFEASTPLFEINYDGDDPEVRHSLDMKSRLVRVCRRWRMLATPLLYQVIIIRHFRHINTLRLIDTIKRAGSNAAFGALPGRVVHRLDIAIREPITTYMALNVRRVLSKIVKALPSLRILVVIQRELRDQNGSSGDLLPPSLDFAQAIDTLGSLTVQKLRWDTDPPLGTKTCRSLLTRLPSLRTLMVGEPGFCPFDLPSLPDLHFATLLHDSSTDSSGTAASFPNLRQALFRPSVRYDIGCITEFLASKAPELTTVYLEMNSSWTRELCRALARHCPHVAHIILFTGYSQWSTWNSGFMDTSGLYFQSSPYFPSITHLGLFGPPFNDDSHCLRIFRWLRSVLIPSSLKVVRFLNPQCVMDMLYRRSAAVAEGLIALPDLRVEDHEGSDLRVRIIVRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXG7</accession>
    <name>W4JXG7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_157311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549798.1">
        <property type="nucleotide sequence ID" value="XM_009551503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXG7"/>
    <dbReference type="GeneID" id="20667715"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_157311"/>
    <dbReference type="HOGENOM" id="CLU_2146194_0_0_1"/>
    <dbReference type="InParanoid" id="W4JXG7"/>
    <dbReference type="OrthoDB" id="3228777at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="112" mass="12477" checksum="3F61D2D4693C3A3C" modified="2014-03-19" version="1">MSIGAVRFLSQRSSLMPGSARDLARSSYMTTDTSRSRMSGLSEFPAPPEQLTVSPTQAGLLQSYLSATSRSQIRVNDVSETVVGVSLRENIPHYDPHYRTTFGREEDFSRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYX2</accession>
    <name>W4JYX2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_453344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549064.1">
        <property type="nucleotide sequence ID" value="XM_009550769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYX2"/>
    <dbReference type="GeneID" id="20676370"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_453344"/>
    <dbReference type="HOGENOM" id="CLU_1170773_0_0_1"/>
    <dbReference type="InParanoid" id="W4JYX2"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="237" mass="25605" checksum="63F5B31981B414E1" modified="2014-03-19" version="1">MEWGRGRGKERAGWRRGCADAVSEGGWGAVAECECECGGWRHGGREGHGEREHGATTKEDEKGEKKAGRPVRACVRACVRAFAVTAARRRGPERQSLAAPALGGTTGLTWTRRRRWCPESTGRIRKRARSGEAKSEMPAAIGWPLRSANSNHSVTGYIPLPSSDLPRPRPLPVALPSTIHVHSTLSTAHTLLYYLPARASPATRGRRPAPCFTAIPHMPQPPSHLSIAGACLVHPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZN8</accession>
    <name>W4JZN8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_454290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550281.1">
        <property type="nucleotide sequence ID" value="XM_009551986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZN8"/>
    <dbReference type="GeneID" id="20676491"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_454290"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_618282_0_0_1"/>
    <dbReference type="InParanoid" id="W4JZN8"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="142"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="443" mass="46820" checksum="8A35F1B7351D7F9C" modified="2014-03-19" version="1">MRVLSSGARLRCVLLSFSSLSSSTMRRGFLLAPNARKDAPRPPASAKKPVDAVKVQRVKDATPLPIPSGLPRPRAPSMSLKEAKADAFARLLAAPNHAMVVTVLPPPPTTFVWPPTACATCLLYPGVKERILATPSFPTPFAPVGAFNITDVPDAGKGVVLARAHAAGALIAKERPLPVLPEMMPYDQRAGGLHPDAMLAMVVENHTNATDRAFLKRLTNYKSANPADLRGIVETNALLIGTLPGSGDLAYAGVCDMTSRFNHSCSPNAHCFWDLDSFSLEVRAPQPIPAGAQATITYLSTTLLPRRARQHELRDKYAFTCARATCALPTPDAVRRSDARRGVLASLCAPGFDGDGDADGGAQEGELRAWAADAPVARGVRLAAMLDAETRDADAAWCAVLQGLVRACCALRDAAGARACPIRAVVLSRAFTGAGGGRKREGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZQ8</accession>
    <name>W4JZQ8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_419839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548907.1">
        <property type="nucleotide sequence ID" value="XM_009550612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZQ8"/>
    <dbReference type="GeneID" id="20673605"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_419839"/>
    <dbReference type="HOGENOM" id="CLU_2391902_0_0_1"/>
    <dbReference type="InParanoid" id="W4JZQ8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="80" mass="9144" checksum="E1057EF1BBFBF1B2" modified="2014-03-19" version="1">MITFCRALRAVYSDTIITNIKRPHKVRRTNKVQIVTLVIHSQRITLSLRAWNAALQTTHTSGIELLVFPGRKETNGETQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4K051</accession>
    <name>W4K051_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WLM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_477994</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549030.1">
        <property type="nucleotide sequence ID" value="XM_009550735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K051"/>
    <dbReference type="STRING" id="747525.W4K051"/>
    <dbReference type="GeneID" id="20677794"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_477994"/>
    <dbReference type="eggNOG" id="KOG4842">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_546356_0_0_1"/>
    <dbReference type="InParanoid" id="W4K051"/>
    <dbReference type="OrthoDB" id="49605at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007218">
        <property type="entry name" value="DNA_pol_delta_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795">
        <property type="entry name" value="UBIQUITIN AND WLM DOMAIN-CONTAINING METALLOPROTEASE SPCC1442.07C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04081">
        <property type="entry name" value="DNA_pol_delta_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="6"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="WLM" evidence="3">
        <location>
            <begin position="122"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW78715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="55039" checksum="D9E19AAB1DBB84BD" modified="2014-03-19" version="1">MVTSVKPIYFQVSHRGNIHPLSLLPDETLAVLQARLEELTSVPPPQQKLLYKGKKPSHGESTTLQDAGFKDGMKVQLLGATAEELGGMQKAEDEQRRRESIMRERAAKGTVKVRSTGPSAFTSAPSGRYRFHRLEPLQHLPNPASALATLERLSSDPAILHVMNKHEFSVGLLTELAPHEDPHLLGLNVNAGQAIKLRLRTDAYDGFRPYLEVRTVLCHELTHNKWGDHDNNFKELNSQLNREVVAFERAKKEGTHTLVDDLGGYEPSSELEAEARTYVLGGSGIAPSGNETVEDRRRRMLEATMNRLRKEEEELEHSCGTAAGPAITKEMAPSTSLTTHSKRSHSAGSMKQSKLSFVTAKRASGASAVKSKLRTAPGLRASSSGTIENSGSVVQAPREKLDPDDKDGRWAKPYAAASAKMGHLQPVHAEGQTKVHHILRVFDLSYEYGPCIGVTRLQRWERADALGLNPPPEIRDILLTEEGTLDKQFSHDVFYVGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4K060</accession>
    <name>W4K060_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_323296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549462.1">
        <property type="nucleotide sequence ID" value="XM_009551167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K060"/>
    <dbReference type="GeneID" id="20670955"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_323296"/>
    <dbReference type="HOGENOM" id="CLU_2638361_0_0_1"/>
    <dbReference type="InParanoid" id="W4K060"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="77" mass="8974" checksum="E3007674CC056806" modified="2014-03-19" version="1">MLWIIDELYTALTGCLLSSCPVRHRYHHCCHPTAFHQESIYTPFSCSSRFNHIPSIEHSRDTSKSRRHRLIDGFDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0J1</accession>
    <name>W4K0J1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_142872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549134.1">
        <property type="nucleotide sequence ID" value="XM_009550839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0J1"/>
    <dbReference type="GeneID" id="20667021"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_142872"/>
    <dbReference type="HOGENOM" id="CLU_2979360_0_0_1"/>
    <dbReference type="InParanoid" id="W4K0J1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="58" mass="6492" checksum="9E537548EF9A44C8" modified="2014-03-19" version="1">MSSSSVQHYDVPKTNDNSMWCSMVEASSASADTEANHVGTRAARYFRKGNQVRRRLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0T8</accession>
    <name>W4K0T8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_419180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548030.1">
        <property type="nucleotide sequence ID" value="XM_009549735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0T8"/>
    <dbReference type="GeneID" id="20673539"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_419180"/>
    <dbReference type="HOGENOM" id="CLU_1992919_0_0_1"/>
    <dbReference type="InParanoid" id="W4K0T8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="125" mass="13081" checksum="1959C44D6B6649AF" modified="2014-03-19" version="1">MQGGDLRAGGIRPTNLLGQWDEDSTGVTGDEDSTGGDVMATNVSYKGDGGLRAGDTIDVNVLRIRGGDSTAGNTIHASEADSVSTRTFALGRDTKDGHMLVQDATIKERSLQVSSLRPCLCVRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1B9</accession>
    <name>W4K1B9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_49936</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548760.1">
        <property type="nucleotide sequence ID" value="XM_009550465.1"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K1B9"/>
    <dbReference type="GeneID" id="20678124"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_49936"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0272">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_6_3_1"/>
    <dbReference type="InParanoid" id="W4K1B9"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="21"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="570"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="616"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="659"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="702"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="745"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="793"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="836"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="879"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="928"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="974"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1019"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1062"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1106"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1149"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW79135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1287" mass="142647" checksum="952A37DA0C86A02B" modified="2014-03-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1C3</accession>
    <name>W4K1C3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_243460</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548180.1">
        <property type="nucleotide sequence ID" value="XM_009549885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1C3"/>
    <dbReference type="STRING" id="747525.W4K1C3"/>
    <dbReference type="GeneID" id="20668985"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_243460"/>
    <dbReference type="eggNOG" id="KOG0423">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_5_3_1"/>
    <dbReference type="InParanoid" id="W4K1C3"/>
    <dbReference type="OrthoDB" id="10069349at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23804">
        <property type="entry name" value="UBCc_UBE2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000031">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="5"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW79612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="153" mass="17143" checksum="92CCBE556069528E" modified="2014-03-19" version="1" fragment="single">SVTPVVLRRLMRELNELRTNPPEGIRAVTNEDNMLDVTGIIQGPEGTPYAGGYFRVKFKFTEEFPAAPPKCWFATKIFHPNVSDAGEICVNTLKKDWKSSYGIAHILVTVKCLLIYPNPDSALDEEAGKLLQENYESYCERAKLITSVHATPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1K1</accession>
    <name>W4K1K1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_386102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548168.1">
        <property type="nucleotide sequence ID" value="XM_009549873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1K1"/>
    <dbReference type="STRING" id="747525.W4K1K1"/>
    <dbReference type="GeneID" id="20672266"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_386102"/>
    <dbReference type="eggNOG" id="ENOG502SMFZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014826_0_0_1"/>
    <dbReference type="InParanoid" id="W4K1K1"/>
    <dbReference type="OrthoDB" id="2559662at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="517" mass="56662" checksum="B5211DE53EB32006" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4K272</accession>
    <name>W4K272_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_419558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548453.1">
        <property type="nucleotide sequence ID" value="XM_009550158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K272"/>
    <dbReference type="GeneID" id="20673576"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_419558"/>
    <dbReference type="HOGENOM" id="CLU_3032614_0_0_1"/>
    <dbReference type="InParanoid" id="W4K272"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="55" mass="6073" checksum="584056820715033B" modified="2014-03-19" version="1">MQASGALPMATMVMIGMPCNPHPANHGFPLERWPSFNPQQMQQNFKDAFGNLGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4K275</accession>
    <name>W4K275_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_322073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548037.1">
        <property type="nucleotide sequence ID" value="XM_009549742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K275"/>
    <dbReference type="GeneID" id="20670810"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_322073"/>
    <dbReference type="eggNOG" id="ENOG502SQ8R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045560_0_0_1"/>
    <dbReference type="InParanoid" id="W4K275"/>
    <dbReference type="OrthoDB" id="3133596at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="45125" checksum="81AB1838F44DC63D" modified="2014-03-19" version="1">MAASIPKNIESKSSPNKKRRRARSSNPVPAGPEATEKCLVTGDSMTESPIHLCHVFHERHWSNHPMLSRLEWAWGMKYDTIQMDQDSNTISLRHDWRDLFESDRWALMPSTDIIDKLWDRWVKISLRDGNVPSIEDIYDGAEIFEYRLVPLFPDVPSISRRNKTEDILEGDEFSGTSVHSYPFDTLPPIFSRVKPHFVVCDAGRKIGLILLQSYRTTSDIARIYGVSMEKAERVMLVVYSTYCTWNDHVHPSMFVTSPRTNNARSRSGLIRPGQPNFVSQRASRPKKRCRATGEVIDAVCPQPNAVQYATCLSRVTPCGSDALIVGDSGWDTEDTEVYAEFERKQVRRAIKASKRWVRDCEREAQSSGGWISCVTDDEQVKSYRQEPARRMTSSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4K301</accession>
    <name>W4K301_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphoribosylformylglycinamidine synthase</fullName>
            <ecNumber evidence="4">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Formylglycinamide ribonucleotide amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Formylglycinamide ribotide amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">HETIRDRAFT_435270</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the FGAMS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="4"/>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548709.1">
        <property type="nucleotide sequence ID" value="XM_009550414.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="W4K301">
        <property type="interactions" value="799"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K301"/>
    <dbReference type="GeneID" id="20674814"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_435270"/>
    <dbReference type="eggNOG" id="KOG1907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001031_0_2_1"/>
    <dbReference type="InParanoid" id="W4K301"/>
    <dbReference type="OrthoDB" id="6666987at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01740">
        <property type="entry name" value="GATase1_FGAR_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02203">
        <property type="entry name" value="PurL_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02204">
        <property type="entry name" value="PurL_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.750:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000005">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000008">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.750">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00419">
        <property type="entry name" value="PurL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040707">
        <property type="entry name" value="FGAR-AT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055181">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010073">
        <property type="entry name" value="PurL_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01735">
        <property type="entry name" value="FGAM_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003672">
        <property type="entry name" value="PRK05297.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18076">
        <property type="entry name" value="FGAR-AT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22689">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13507">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01211">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109736">
        <property type="entry name" value="FGAM synthase PurL, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="PurS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase N-terminal" evidence="20">
        <location>
            <begin position="37"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase linker" evidence="19">
        <location>
            <begin position="191"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="18">
        <location>
            <begin position="466"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="FGAR-AT PurM N-terminal-like" evidence="21">
        <location>
            <begin position="692"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="18">
        <location>
            <begin position="885"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF18076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF22689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ETW80198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1340" mass="144562" checksum="41478E73868A21A3" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3W0</accession>
    <name>W4K3W0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_320637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547180.1">
        <property type="nucleotide sequence ID" value="XM_009548885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3W0"/>
    <dbReference type="FunCoup" id="W4K3W0">
        <property type="interactions" value="177"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K3W0"/>
    <dbReference type="GeneID" id="20670679"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_320637"/>
    <dbReference type="eggNOG" id="KOG1235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_2_5_1"/>
    <dbReference type="InParanoid" id="W4K3W0"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="2">
        <location>
            <begin position="160"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW80424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="618" mass="70495" checksum="7C86959C36E0264D" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3W6</accession>
    <name>W4K3W6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonucleases P/MRP subunit Pop8-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_322474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548559.1">
        <property type="nucleotide sequence ID" value="XM_009550264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3W6"/>
    <dbReference type="GeneID" id="20670858"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_322474"/>
    <dbReference type="eggNOG" id="ENOG502T1V4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163478_0_0_1"/>
    <dbReference type="InParanoid" id="W4K3W6"/>
    <dbReference type="OrthoDB" id="3265020at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049128">
        <property type="entry name" value="Pop8-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20976">
        <property type="entry name" value="Pop8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonucleases P/MRP subunit Pop8-like" evidence="1">
        <location>
            <begin position="22"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="108" mass="11402" checksum="56F3155E9DA0924C" modified="2014-03-19" version="1">MGHSPFPLPQTYHYILFSLSPPTTDPLRIRKSIQDALSQSFGLTSASTYLDILWIADDGNQSVVRTGPADATRVMAAAAAASPGAGALRLSTTQDSPFLPSLIPAFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5E8</accession>
    <name>W4K5E8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="5">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HETIRDRAFT_319856</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the TOP6A family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="5"/>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547728.1">
        <property type="nucleotide sequence ID" value="XM_009549433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5E8"/>
    <dbReference type="FunCoup" id="W4K5E8">
        <property type="interactions" value="102"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K5E8"/>
    <dbReference type="GeneID" id="20670629"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_319856"/>
    <dbReference type="eggNOG" id="KOG2795">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037229_0_1_1"/>
    <dbReference type="InParanoid" id="W4K5E8"/>
    <dbReference type="OrthoDB" id="5377392at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013048">
        <property type="entry name" value="Meiotic_Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF0">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01551">
        <property type="entry name" value="SPO11HOMOLOG"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52041">
        <property type="entry name" value="TOPO_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Spo11/DNA topoisomerase VI subunit A N-terminal" evidence="13">
        <location>
            <begin position="5"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="14">
        <location>
            <begin position="114"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="12">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETW81048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="325" mass="36027" checksum="28C3A22C210C4B0C" modified="2014-03-19" version="1" fragment="single">SSRFLAQLFRIVDLAHQAVVDGIPTTKRDMYYKDVPLFKSQSVVDRFIDDIAATIGVGRADLNVRASSKGLVCGSGLCIQLVGDEILRATDSEGTLIPTAEDIVRFELEQDVSWVLIVEKEAVFQTLCRLRFTKHQSLPGPGLIITGKGYPDLATRQLVKTLSDNLPPSIPILALVDGDAYGLDIVSTYKFGSHAMQHEREGLAASRVVCIGIWASELSKREPSLFLGAPNSLNYIRLGIDKDMLIPISNHDEKKAIKMLQRPPDMLPVKWKKELMAMLHTRRKAETEILSSVNMDGFEGAKHDKHPILQYLATKINEHIASLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6C1</accession>
    <name>W4K6C1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_169377</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547348.1">
        <property type="nucleotide sequence ID" value="XM_009549053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6C1"/>
    <dbReference type="STRING" id="747525.W4K6C1"/>
    <dbReference type="GeneID" id="20668215"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_169377"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002572_0_0_1"/>
    <dbReference type="InParanoid" id="W4K6C1"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054295">
        <property type="entry name" value="CHS4-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF41">
        <property type="entry name" value="CHITIN SYNTHASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22997">
        <property type="entry name" value="CHS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="812"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="843"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="869"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase 4-like" evidence="13">
        <location>
            <begin position="236"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="964"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1063"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="979"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1087"/>
            <end position="1102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW80621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1134" mass="123831" checksum="FE0B2EE4F668704A" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6N5</accession>
    <name>W4K6N5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peroxidase</fullName>
            <ecNumber evidence="7">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_150650</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the peroxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="7"/>
    <dbReference type="EMBL" id="KI925459">
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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        <property type="term" value="F:peroxidase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ccp1-like"/>
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        <property type="entry name" value="Haem_peroxidase"/>
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        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF53">
        <property type="entry name" value="HEME PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
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        <property type="entry name" value="Heme-dependent peroxidases"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0349">Heme</keyword>
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    <keyword evidence="1 7 9" id="KW-0575">Peroxidase</keyword>
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    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006994344" description="Peroxidase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="537"/>
        </location>
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        <location>
            <begin position="125"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW81005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="537" mass="56046" checksum="7805B5F7E650D466" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6Z6</accession>
    <name>W4K6Z6_HETIT</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_426913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
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            <taxon>Basidiomycota</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
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        </location>
    </feature>
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            <begin position="152"/>
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        </location>
    </feature>
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        <location>
            <begin position="188"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW81524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="405" mass="44715" checksum="93B470F4615D0577" modified="2014-03-19" version="1">MASRQLCIPSSRLESLVYQEFTFISQYLAIVATSSLFYGFQAILFFLSTYIMSTRNKASLQTRAVLWGVTFVMFGASTADYALGFVHDRIFILNMQSYFLERSSNPVYPMMLFELQAVKPLLQARLFAPIINFVICDAIILWRAWVLWNYSLVVLLISSVCMLGAVGTGLFTLAERRMFFAAGGSMNIGMYGLSIATLGTNVVGTALIAYRAWQLRRQITSNISGSQHPRTKVQKILIFLVESGALYVVIWGRLGREADYPLSFIKVLFILSQSGIFSDLGRAIMGRSMTSIAGVYPTTIIVLVALQQSTSEMTVISPSRTLSLRFVSRDSRSASIPQCPRRPSSGADAHADTSTSMGVFSQRALLDSQESIITFAHQGPCARDKSQKWALLGAAGPIVKTRSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7D8</accession>
    <name>W4K7D8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable 26S proteasome regulatory subunit p27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_51465</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
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                <person name="Rouze P."/>
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                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p27 family.</text>
    </comment>
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        <property type="protein sequence ID" value="ETW81713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009547548.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="W4K7D8">
        <property type="interactions" value="694"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K7D8"/>
    <dbReference type="GeneID" id="20678181"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_51465"/>
    <dbReference type="eggNOG" id="KOG3129">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073146_0_0_1"/>
    <dbReference type="InParanoid" id="W4K7D8"/>
    <dbReference type="OrthoDB" id="72325at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nas2_N"/>
    </dbReference>
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        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035269">
        <property type="entry name" value="PSMD9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18265">
        <property type="entry name" value="Nas2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nas2 N-terminal" evidence="5">
        <location>
            <begin position="16"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="118"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00068021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW81713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="208" mass="22511" checksum="B67B794C45C278E0" modified="2014-03-19" version="1">MGYSLPSPTSPVERARALMARKDAIEAELGAQAAILTANGTNMQEPLVDREGFPRADIDVWAVRHARVRVIELRNDLSALMGEIGKALESVYDPALAAPAGEHADEEARGALRPFAKVNAVAPDSPAADAGLQRDDLVVKFGHLRHTSFPTASSLQPLAEVVAENENKEIRVFVRRGEQRTVVLNFTPRQGWGGRGMLGCHLVPYTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7H1</accession>
    <name>W4K7H1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thiamine thiazole synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Thiazole biosynthetic enzyme</fullName>
            <ecNumber evidence="6">2.4.2.60</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_440039</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) = [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + nicotinamide + 3 H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:55708"/>
            <dbReference type="Rhea" id="RHEA-COMP:14264"/>
            <dbReference type="Rhea" id="RHEA-COMP:14265"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:90873"/>
            <dbReference type="ChEBI" id="CHEBI:139151"/>
            <dbReference type="EC" id="2.4.2.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homooctamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">During the catalytic reaction, a sulfide is transferred from Cys-308 to a reaction intermediate, generating a dehydroalanine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the THI4 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.60" evidence="6"/>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546328.1">
        <property type="nucleotide sequence ID" value="XM_009548033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7H1"/>
    <dbReference type="FunCoup" id="W4K7H1">
        <property type="interactions" value="501"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K7H1"/>
    <dbReference type="GeneID" id="20675220"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_440039"/>
    <dbReference type="eggNOG" id="KOG2960">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053727_0_0_1"/>
    <dbReference type="InParanoid" id="W4K7H1"/>
    <dbReference type="OrthoDB" id="410463at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160205">
        <property type="term" value="F:cysteine-dependent adenosine diphosphate thiazole synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052837">
        <property type="term" value="P:thiazole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03158">
        <property type="entry name" value="THI4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027495">
        <property type="entry name" value="Sti35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002922">
        <property type="entry name" value="Thi4_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00292">
        <property type="entry name" value="sulfide-dependent adenosine diphosphate thiazole synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43422">
        <property type="entry name" value="THIAMINE THIAZOLE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43422:SF3">
        <property type="entry name" value="THIAMINE THIAZOLE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01946">
        <property type="entry name" value="Thi4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="200"/>
            <end position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="387"/>
            <end position="389"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="2,3-didehydroalanine (Cys)" evidence="6">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW81714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="422" mass="44417" checksum="2DA48017013576F8" modified="2014-03-19" version="1">MACRTAWRLYGVSTATLMTRAGSRRGVVFLRGGSLPTRDAGPLTSVEGIRSMASSAGDSAVIVARAYRPLRAGRPALWGVRYLSPAHRARTVSVHPLLMSPPVATAPPLESAVPDAAPPPKQASDKAGARADALEDYDGRYRFAPIEEAQVARAMIKRYSATLYERAVSDVVIVGAGSAGLSCAYHLAKARPELKITIVEASVAPGGGAWLGGQLMTPMVVRKPADRFLEELGVPFEDEGAFVVVKHAALFTATVLAHVLRMPNVVLLNATAVEDLIVHGRSDGAQARVAGVVVNWTLVALNHATQSCMDPSTLTAPVVVSATGHDGPMGAFCARRLVSAGLRPALGSMRALDMRRAEPAIVNGTREVVPGLVMAGMELAEHDGSNRMGPTFGAMMASGIKAAKEAMRVLDSHRIVDGRVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7H2</accession>
    <name>W4K7H2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_440577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547697.1">
        <property type="nucleotide sequence ID" value="XM_009549402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7H2"/>
    <dbReference type="STRING" id="747525.W4K7H2"/>
    <dbReference type="GeneID" id="20675278"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_440577"/>
    <dbReference type="eggNOG" id="ENOG502S672">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055329_0_0_1"/>
    <dbReference type="InParanoid" id="W4K7H2"/>
    <dbReference type="OrthoDB" id="2562444at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="35350" checksum="DB16B6213DB18E54" modified="2014-03-19" version="1">MRDDGDEYIDDPDARAVTESGIPEIPDSNPGGYGDHRAQSPMSRNPADRGRDSGWAGDDLPLPPAWQRIHQRLLNWAIVWPLSELESALNSTTRGNQVDEVALSIWSTQTYKRYVRSKMTDSPPGRVDRLFVPPNMADAISNAVFNGRHGDASGMLRELWYPFGLDGMPRLLIVLARHRSDANHWVVHRFSLPDGTLTTYDSYPERCLPDGRPLGWWFAIRIAWPNAIYPSPDHLMQKMVRLHRPMQLGIDNSVAAAGIWRNLLMGSRAERSLDLERLRDLINTEVKNLRQRKQMGKLSIGAPRPNWEDMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7J4</accession>
    <name>W4K7J4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PDZ GRASP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_242192</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
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                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
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        <property type="project" value="UniProtKB-KW"/>
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        <ligand>
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                <person name="Yakovlev I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
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        </location>
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            <begin position="50"/>
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        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW81061.1"/>
        </source>
    </evidence>
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        <source>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="Deflorio G."/>
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                <person name="Fossdal C.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
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        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="143" mass="15761" checksum="FB252DDA7E508B70" modified="2014-03-19" version="1">MSAFNSMYIDAQTNNASDLTEAQAIHDAGLIILYNVTALALQTLFYGIYVVLILFSTWVLCQRGLPRANLMMLVTILVMFISSTSGFWVHTVTVLKRIRSLLVEQPGEPIAAKLPLIRDSLRGMEGGAFYCSLINVSVISVCE</sequence>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:18364"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.70"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:18563"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="16">Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.70" evidence="3"/>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546657.1">
        <property type="nucleotide sequence ID" value="XM_009548362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8D3"/>
    <dbReference type="FunCoup" id="W4K8D3">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K8D3"/>
    <dbReference type="GeneID" id="20670531"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_318728"/>
    <dbReference type="eggNOG" id="KOG1435">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015631_0_3_1"/>
    <dbReference type="InParanoid" id="W4K8D3"/>
    <dbReference type="OrthoDB" id="10262235at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000009">
        <property type="entry name" value="C-14 sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="369"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00060638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00077841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00083315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ETW82092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="429" mass="48621" checksum="E6A3C0C71F572C5A" modified="2014-03-19" version="1">MTDLNPRTKSYEFLGPPGALAVTIGVPIMTYALYFSCSEVSGGCPPTPLSTLIPTIQQAVSDTEWWKSLLDTKALAIYSSWYAFCIVAWAILPGDWVQGSQLRNGKYQSYKINAFSTSLLALGLATGYIMRFGVQSFTFFYEHWVGFVTAALLNSILQGLLWYGLSFCQGKLLALGGNSGNPIYDFYIGRELNPTVLGLDIKSFNELRPGMILWLLIDISMACEQATRLGGRITDSMGLVLFFQSLYIMDALYNEPAILTTMDIISDGFGFMLSVGDLVWVPFVYSLQARYLAFHPKDLGYTWSAAILAVNFLGYWIFRSANNEKNEFRNGRNPKNLTYMPTERGTKLLTSGWWGASRHPNYMGDLLMALAWSLPTGFETPVTYFYVVYFAVLLIHRQRRDDENCEKKYGKDWHKYMKLVPYRIIPFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8E7</accession>
    <name>W4K8E7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 monooxygenase 38</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cyp38</name>
        <name evidence="11" type="ORF">HETIRDRAFT_101388</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546669.1">
        <property type="nucleotide sequence ID" value="XM_009548374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8E7"/>
    <dbReference type="STRING" id="747525.W4K8E7"/>
    <dbReference type="GeneID" id="20665762"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_101388"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_3_1"/>
    <dbReference type="InParanoid" id="W4K8E7"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW82107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="489" mass="55004" checksum="20231A24FDB82B04" modified="2014-03-19" version="1">MSSINLEFLDFVALITFLVFAKAYWTKHRKPYGLPYPPGPMPLPLVGNIFDILNKNTWKTYAKWGKEYGNVVSFSVLGQRLVIINSYKAAKDLFDKRGEIYSDRPVVPVFKIMGVDWWNTVFTSYSHEWRAQRRVSDHSLRPSAALLYRPMQRRYTHDFLKKLLHRPEALDKHITHLTGAIVINLAYGYEIAESNDRFVSLAEEISHRSSAVFLPGATLVNALPILRHLPAWVPGMRFKGMASETARIARDMVNAPYEYVKEAMRDGTARPSLTRDNLNACQGIAPTEQEEFTIKSVAATLYTAGADTSKAALGSAFLALVLNPAVQKRAQAEIDVVVGRGRLPDFGDYENLPYVNAVCMEVKRWHPVVPLGVSHVIREDDVYEGYYIPKGTNIFANLWAILQDPETYPDPDAFKPERFLTSDGKIKEDPLLSSVFGFGRRICPGRHLADATLWIVIASVLSVFTVDHAKDADGNIIPVERAYTDAAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8I0</accession>
    <name>W4K8I0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Non-catalytic module family EXPN protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_45142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545801.1">
        <property type="nucleotide sequence ID" value="XM_009547506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8I0"/>
    <dbReference type="STRING" id="747525.W4K8I0"/>
    <dbReference type="GeneID" id="20676152"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_45142"/>
    <dbReference type="eggNOG" id="ENOG502S6X4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047639_6_1_1"/>
    <dbReference type="InParanoid" id="W4K8I0"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="92" mass="9488" checksum="FF56983FF4E940BC" modified="2014-03-19" version="1">MHQGTYFAVGLGACGWTNTDSDYIVALASADYGSGAHCGKTISVSANGKTHSAQVVDKCPGCSSGDLDMSPALFTTFADESVGVVQVTWSYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4K954</accession>
    <name>W4K954_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aquaporin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_51894</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545856.1">
        <property type="nucleotide sequence ID" value="XM_009547561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K954"/>
    <dbReference type="STRING" id="747525.W4K954"/>
    <dbReference type="GeneID" id="20678195"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_51894"/>
    <dbReference type="eggNOG" id="KOG0224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020019_9_0_1"/>
    <dbReference type="InParanoid" id="W4K954"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000027">
        <property type="entry name" value="MIP aquaporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02019">
        <property type="entry name" value="AQUAPORIN7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="281"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW81616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="345" mass="37655" checksum="7CBC9BC3F18EEE78" modified="2014-03-19" version="1">MSLPVLKSFGRRRSSDAMSKEVKHLEDVDESPEDFEALHEYYTKYPNRWSRVREHLREPAAEMLGTMILILFGNGVDCQVVLSSNTAVSATPKGDYLSLNFGWACGAALGVWVSGGVTGGHINPVVTLALAVFRDFPWKKVPIYIFAQILGAWIGSLIVFANYFHAIYIFEGGRKALSVPGTASLFATYALDYMPAANSFFDQFVGTFALVLVVFAVSDKRNGPPPAGLVPLVIFIFILGVGTAFGMQTGYAINPARDLGPRIMTAMVGYGREVFNFRDQYWLWCPILGPIAGGLVGAFVYDALIFLGDESILNRPNAAARKHHAHALNAERQKPIAGAAVDEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4K976</accession>
    <name>W4K976_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_317981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546860.1">
        <property type="nucleotide sequence ID" value="XM_009548565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K976"/>
    <dbReference type="GeneID" id="20670464"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_317981"/>
    <dbReference type="HOGENOM" id="CLU_2533612_0_0_1"/>
    <dbReference type="InParanoid" id="W4K976"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="84" mass="9485" checksum="048EB86053318707" modified="2014-03-19" version="1" fragment="single">EEGGRVLPSSRTHARLLVNPSARPFLILHHCRHRPRARPRILTFSSHLVLLTMRPLGPRTHSTPHTLDPAHARSPICRPSRARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-09-13" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9Q6</accession>
    <name>W4K9Q6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_45037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545799.1">
        <property type="nucleotide sequence ID" value="XM_009547504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9Q6"/>
    <dbReference type="GeneID" id="20676037"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_45037"/>
    <dbReference type="HOGENOM" id="CLU_212986_0_0_1"/>
    <dbReference type="InParanoid" id="W4K9Q6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="55" mass="6388" checksum="8FFDE67458EEA3D2" modified="2014-03-19" version="1" fragment="single">PFGIITIDFITNLSKLNRYDSLHIVIDRFIKTVVITLYKKTINLDRIAKILLKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAA7</accession>
    <name>W4KAA7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_119492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545048.1">
        <property type="nucleotide sequence ID" value="XM_009546753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAA7"/>
    <dbReference type="STRING" id="747525.W4KAA7"/>
    <dbReference type="GeneID" id="20666657"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_119492"/>
    <dbReference type="eggNOG" id="ENOG502SKHB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002498_9_1_1"/>
    <dbReference type="InParanoid" id="W4KAA7"/>
    <dbReference type="OrthoDB" id="3183767at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="405" mass="46730" checksum="6B9F0E3A998D5E77" modified="2014-03-19" version="1">MKKPAARDFKDLIQCAIPCFDSLLPAPHHAIVMDLLFALGIWHAYAKLWLHTNSTLTSLELATTALSQHMRKFKATTCASYETMELPGEETRHPGKQRKDFNISTYKNHTLGHYAKTIRLFGTIDLYTSQVGELQHRHSKHCFKRTNKNRFTKQLAQHESRERVLHKVNERMMASSQPLPAPAGKKLAARGDALLCTRPEMHHHIARSVKEYDYITPWLTKNLGDPALKLFFLEEFLPRLRDYLLARLLGKIWDGDEHSFTDAEGRQILFDNDHLYRHSTVQINYTTYDLRRAQDSINTHSHADIMLLSHEDDGDATPPHPYWYARVIGIYHVFVMHPTLSPEPRRLDFLWVRWFGRDMGSPSGWAARPLHRVGFVDSNDPSAFGFVNPQDHLQNCRSMATDDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAW9</accession>
    <name>W4KAW9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_315686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544867.1">
        <property type="nucleotide sequence ID" value="XM_009546572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAW9"/>
    <dbReference type="GeneID" id="20670243"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_315686"/>
    <dbReference type="HOGENOM" id="CLU_2812676_0_0_1"/>
    <dbReference type="InParanoid" id="W4KAW9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="67" mass="7798" checksum="A0193AF3C9D48622" modified="2014-03-19" version="1">MRDDRSFRLLWTKPLVRHPIRGLITYVTGILPSLLQLLFIVVITLVPISTFIRLVVWVSIIVISWVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBD6</accession>
    <name>W4KBD6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_315017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545008.1">
        <property type="nucleotide sequence ID" value="XM_009546713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBD6"/>
    <dbReference type="GeneID" id="20670184"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_315017"/>
    <dbReference type="HOGENOM" id="CLU_1943117_0_0_1"/>
    <dbReference type="InParanoid" id="W4KBD6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="130" mass="14472" checksum="B1FF92581D4B80D0" modified="2014-03-19" version="1" fragment="single">LGAHSTSTLISGSIFYLGALFTIKTYIQLWNKPAFAPHSSELIRIRLNHRNCLRQPPKTCHPRRSASFVFVLVPSLVPPSSLVYCQSPVWLLKHVVVGRDTTFSLPTASPTRPTEHSVGVRRSPETVRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBF1</accession>
    <name>W4KBF1_HETIT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_450287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544746.1">
        <property type="nucleotide sequence ID" value="XM_009546451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBF1"/>
    <dbReference type="GeneID" id="20676023"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_450287"/>
    <dbReference type="eggNOG" id="ENOG502SBIS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1057913_0_0_1"/>
    <dbReference type="InParanoid" id="W4KBF1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="263" mass="27748" checksum="3DF9DB6E6A01A859" modified="2014-03-19" version="1">MVSGRHGLVSHPSVIASHHLTQPPRVSHDGLEPAAPAKDLAKLSPYASELYRVRLLGSTGPVIHGPSTFLEFTSSHRYTSLLNIALSRDRGATEPRALVAFIAAIVRAFVAALEVTLVTRALAHGPPLRFTRKYSLGSQRGDIADDSGQDIADDLGEDIADNPGQDVVDDLGQDVADNLGQDITDNSGQDGSWRGDIVDDSGQDVTDNLGQDVTDNSGQDVADDSGLGYRRGDVADDSGQDIADDLGEDITDNPGQDVADDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBF8</accession>
    <name>W4KBF8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_108913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545025.1">
        <property type="nucleotide sequence ID" value="XM_009546730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBF8"/>
    <dbReference type="GeneID" id="20666395"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_108913"/>
    <dbReference type="HOGENOM" id="CLU_1845355_0_0_1"/>
    <dbReference type="InParanoid" id="W4KBF8"/>
    <dbReference type="OrthoDB" id="3037028at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="1">
        <location>
            <begin position="24"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="139" mass="15762" checksum="1568888D418B2C67" modified="2014-03-19" version="1">MKWGPCRDLLDVRAFLGTIGVIAAQDNLQSALLKLPALRPIDYGSAANVILAVDTSQIAVSFHLCQCALNNLWVWYYARFGSITLNNHELRFSQPKLELYGLFHALRSLKMYLIGVRNLIVEVDACYIKGIIWKNTPFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBH0</accession>
    <name>W4KBH0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_316786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545033.1">
        <property type="nucleotide sequence ID" value="XM_009546738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBH0"/>
    <dbReference type="GeneID" id="20670358"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_316786"/>
    <dbReference type="HOGENOM" id="CLU_1943117_0_0_1"/>
    <dbReference type="InParanoid" id="W4KBH0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="145" mass="16262" checksum="E59B06BD5B8953D0" modified="2014-03-19" version="1">MPVPATYAQATDPKWLGTHLTSTLISCLIFYLGALLTIETYIQLWNKPAFAPHSSELSRTHLNHRNHLCRLLKTCHPHCLASFAFVLVSSLIPSSSLVYCQSPVWLLKHVVVGRDTTFSLPTTLPTQLTERLVGVRRSPETIWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBZ4</accession>
    <name>W4KBZ4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_450890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545535.1">
        <property type="nucleotide sequence ID" value="XM_009547240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBZ4"/>
    <dbReference type="STRING" id="747525.W4KBZ4"/>
    <dbReference type="GeneID" id="20676089"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_450890"/>
    <dbReference type="eggNOG" id="ENOG502SE95">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112088_1_0_1"/>
    <dbReference type="InParanoid" id="W4KBZ4"/>
    <dbReference type="OrthoDB" id="529205at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="180" mass="19984" checksum="B566D0943306ED76" modified="2014-03-19" version="1">MSSLTIRIALKFVPKSLTMSRPYQTATASMRAMSTSSMHENDPEVLEREKRRNLSRVGYQTSAPVDDAPGWNELLATNAEASIKADRTPNDASVADLVRRTVAHMKAKNSPEERFEGSEATYDRDEISGPLRGAGRGVSSIETDGYEEEMEKVDGEWHRSTVKKHTEVVMDPKEAVKGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KC27</accession>
    <name>W4KC27_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit J</fullName>
            <shortName evidence="4">eIF3j</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 30 kDa subunit homolog</fullName>
            <shortName evidence="4">eIF-3 30 kDa subunit homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">HCR1</name>
        <name evidence="6" type="ORF">HETIRDRAFT_474472</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit J family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545586.1">
        <property type="nucleotide sequence ID" value="XM_009547291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KC27"/>
    <dbReference type="FunCoup" id="W4KC27">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KC27"/>
    <dbReference type="GeneID" id="20677565"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_474472"/>
    <dbReference type="eggNOG" id="KOG4813">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085806_0_0_1"/>
    <dbReference type="InParanoid" id="W4KC27"/>
    <dbReference type="OrthoDB" id="20381at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.60">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03009">
        <property type="entry name" value="eIF3j"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023194">
        <property type="entry name" value="eIF3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013906">
        <property type="entry name" value="eIF3j"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08597">
        <property type="entry name" value="eIF3_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW83318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="253" mass="27878" checksum="F6C2AF8DB0FA7DBE" modified="2014-03-19" version="1">MSDWEASDNEAAPPPPSAVARKVTKKWEGEDEEDDAPVSDWEQSSDEEEKPQPTASVAPPKKKGTLKAKLAEKEAAKAAVRASVDDDLYDEDAVLDPREKARLDRERELAADLNNAVDLFGAAALGGTSNKDLDALISFNPRTKDDFEKLSHNIIEFIVKRYQDKPLYAAFVEHHVRELAMPLRDVEVRKAASGLTTLANEKQKEQRDKASGKKKPKATAKPALGASKVSNKHDTNTYEEALDDFGSNGDDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCD6</accession>
    <name>W4KCD6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_433899</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545650.1">
        <property type="nucleotide sequence ID" value="XM_009547355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCD6"/>
    <dbReference type="STRING" id="747525.W4KCD6"/>
    <dbReference type="GeneID" id="20674709"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_433899"/>
    <dbReference type="eggNOG" id="ENOG502RZF1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026455_1_0_1"/>
    <dbReference type="InParanoid" id="W4KCD6"/>
    <dbReference type="OrthoDB" id="4179406at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="259"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW83394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="45083" checksum="839D04601CD8D2CC" modified="2014-03-19" version="1">MAETRRRLTRDAASSDDEGWEDINRQARMQSPSGAVSASTYVIDVVGTAVRLLKRPISFFLFLYLLGLLLARASSTIRSTLSPLCFVPGLSRLCPAPLTHAQRGANKGHDAKPQWADYPGLVRVQGQTLGALLDEAGTGRGLALEIAHAQIATRDLAALVAVSDLTARDALAESLTGFVKAAQKAGRGLQRFSAKVSGAVDNVMAVNDYALHAIEVANKPPSALIVRTLWPFATNNAEATKEVVTKTFMDAMSALSLNMRRLVVEAEVSLGDLEQLEERLSSLAELIAREDSAISSTKADLLADLWTRLGGNRKAVRGLNGHLALLKGLGAYRQQAVTHVMAALQTLQGMSEEMEELRARVAAPELIGERIPIEVHMKSIRSGLDRLKERRVKAIEKEEQIVSKVLAAVAGSETALAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCJ3</accession>
    <name>W4KCJ3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_451065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009547449.1"/>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_451065"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_010119_10_0_1"/>
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    </dbReference>
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        <property type="entry name" value="Chromosome 21, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
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    </dbReference>
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        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
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        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
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        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
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        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
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        <property type="entry name" value="Clavaminate synthase-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="2">
        <location>
            <begin position="28"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="1">
        <location>
            <begin position="203"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW83498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="42426" checksum="03E6D71E5888CF51" modified="2014-03-19" version="1">MPAPVSLGSYSFVAETKEDLDWAELVTLDLALYHTPEGKKDLAAFLIKALREKGFFYVKNFNISQEAVNRQFALGRELYELPLEEKLKYVPQGLDEGQFNGYVPAGRRLLEPTEGIRDRVEVYNIPKFNGSFKHQHPKLIQDHIEEIEQFARALHSEVLDRLHVLLAIALELPEDYFTKIHQYEVKSEDHLRYMKYGKMSPEENQKLGNIWGGGHTDLGSFTLLFRQPVAALQIRDPVHNQWKWVKPQDATLTVNACDALSFLTGGYVQSTVHRVAAPPKDQQHVDRLGLLYFSRPHNDILLRTAHESPVLQREGFTQNVFEKSGNPVPTTEAWTFAKQKWQRTKGAYTYDPTFRTAVILPGYQEKLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEA7</accession>
    <name>W4KEA7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_472606</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="747525.W4KEA7"/>
    <dbReference type="GeneID" id="20677465"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_472606"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015466_0_0_1"/>
    <dbReference type="InParanoid" id="W4KEA7"/>
    <dbReference type="OrthoDB" id="9976382at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030905">
        <property type="term" value="C:retromer, tubulation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="BAR_SNX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053055">
        <property type="entry name" value="VPS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="132"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Sorting nexin/Vps5-like C-terminal" evidence="3">
        <location>
            <begin position="214"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="591"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW84148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="680" mass="74516" checksum="6B4BAA3801729926" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KED0</accession>
    <name>W4KED0_HETIT</name>
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        <recommendedName>
            <fullName evidence="1">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543873.1">
        <property type="nucleotide sequence ID" value="XM_009545578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KED0"/>
    <dbReference type="GeneID" id="20677470"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_472645"/>
    <dbReference type="eggNOG" id="KOG3947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041441_4_0_1"/>
    <dbReference type="InParanoid" id="W4KED0"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="47"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="314" mass="35024" checksum="1CF40758B065EAB5" modified="2014-03-19" version="1">MSVLVFKDPTPSETNPPPSITTSTAIIHSIYDPSSIPPKPSEGNWTRFVCISDTHQHVFPVPDGDVLLHSGDLTGTGTLRGFKITMDWLYGLTHPLKIIIAGNHDLTLHEPWYETSFYRWHQSKENTTAIRDLVSGEAARRAGVVYLEGETYDFQTHDDGRIWTVYGSPWSPDFFNWAFNYDRGQDADELVAKFPKTDILLTHGPPHEILDKVSDGLSVGCESLRARLPELRPRLHVFGHIHEDHGVQVGEWASASDLESSTSGQTTDLDGGTERTVFVNAANWPAGRRIQTGERIPFAGRGFQPVIVDLRDDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEK3</accession>
    <name>W4KEK3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIF subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TFIIF medium subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TFIIF-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_409253</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545742.1">
        <property type="nucleotide sequence ID" value="XM_009547447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEK3"/>
    <dbReference type="FunCoup" id="W4KEK3">
        <property type="interactions" value="474"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KEK3"/>
    <dbReference type="GeneID" id="20672762"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_409253"/>
    <dbReference type="eggNOG" id="KOG2905">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047858_2_0_1"/>
    <dbReference type="InParanoid" id="W4KEK3"/>
    <dbReference type="OrthoDB" id="449280at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000035">
        <property type="entry name" value="General transcription factor IIF subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="11">
        <location>
            <begin position="117"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="179"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW83496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="229" mass="26198" checksum="0C63BDE209842F8B" modified="2014-03-19" version="1" fragment="single">MDQYEMDMLNQDVNNQIVVAEREKEPHSRARTTIMTGKVKHECNMRPRLSANYRRMIKARTQAANTSTRPIKRIEDALPGGRGGIIKLSSGVAPAAGFSEHIRPKIKPAKGQYERMARMPRNQLLDLLFGLYREREQWPLKVLREKTQQPEVYLKEVLSEIAFLHRSGEFNGSWELKGSFKGDGVKGEGGSITELYKREPPPDMDMPMADEDEDEDDDDDDDDDMEEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KF89</accession>
    <name>W4KF89_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_449870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544062.1">
        <property type="nucleotide sequence ID" value="XM_009545767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KF89"/>
    <dbReference type="GeneID" id="20675990"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_449870"/>
    <dbReference type="HOGENOM" id="CLU_1185139_0_0_1"/>
    <dbReference type="InParanoid" id="W4KF89"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="234" mass="25882" checksum="2A114F49D79FE781" modified="2014-03-19" version="1">MNTPPSLTQPDDNSSPSSDPLESPFSFVFTSSRYAPTTSESLVELSRPDLTATQLGRHAQGAINIKSTLQPPSPTVDFIPFSPNYHTRSAHSFSIQSSCSDSVLSRESYAQRSRRSTFGPDVFSGRSSVSSGPPSKYLPAHQHTRASSVSAPLQRNYLYGGSPELSITELLWTNPDRSQTRRGPESVMRRRSSTRKTVVLDEGECWKKPMLKPDAQVTNPPKDCLLDPKFQCFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4KF93</accession>
    <name>W4KF93_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_155549</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544188.1">
        <property type="nucleotide sequence ID" value="XM_009545893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KF93"/>
    <dbReference type="STRING" id="747525.W4KF93"/>
    <dbReference type="GeneID" id="20667580"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_155549"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008523_10_4_1"/>
    <dbReference type="InParanoid" id="W4KF93"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW84527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="440" mass="49543" checksum="7EF717338601E73F" modified="2014-03-19" version="1">MNLSSIDSTLDYTSLEHPAFSGYSVRIKKTEFCDHTVNVYTGYLDVDQGAKHLFFYFFESRRDPAQDDVMMWINGGPGCSSSMGLLMELGPCSVDMKNVSSNGTIWNPHSWNNEANIFFLDQPVGVGFSYADHGETVETTEDAARNVHAFIAIFFETFDQFKGRPLHLAGESYGGRYLPVFAGEIWDRNRFAEEEGRPAINLQSVLIGNGITDISTLYPGRYEIECGTAALDVPFQFISSCVRMKKALPRCEKAMDDYCVQSFDEMNCRAAVNFCNDQLSMCLGDDLCYLENTAITEYLDQPSVREALGVEIPYGFAPCSRAVGREFDLHMDKYAVPTQYYVANLLERGVRVLIYAGTYDWQCNWVANRLWVDKLEWAGQDGYRRAAWRDWTVDGAKAGETKAWGNLTFATVRGAGHMVPHDKPAEAFAMVSRWVAHQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFB3</accession>
    <name>W4KFB3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-mannosidase A</fullName>
            <ecNumber evidence="6">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Mannanase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">beta-e1</name>
        <name evidence="18" type="ORF">HETIRDRAFT_62665</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="6"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543268.1">
        <property type="nucleotide sequence ID" value="XM_009544973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFB3"/>
    <dbReference type="STRING" id="747525.W4KFB3"/>
    <dbReference type="GeneID" id="20678610"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_62665"/>
    <dbReference type="eggNOG" id="KOG2230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005015_3_0_1"/>
    <dbReference type="InParanoid" id="W4KFB3"/>
    <dbReference type="OrthoDB" id="2866996at2759"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041625">
        <property type="entry name" value="Beta-mannosidase_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF5">
        <property type="entry name" value="BETA-MANNOSIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17753">
        <property type="entry name" value="Ig_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="10 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844261" description="Beta-mannosidase A" evidence="14">
        <location>
            <begin position="24"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="17">
        <location>
            <begin position="33"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="16">
        <location>
            <begin position="789"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase Ig-fold" evidence="15">
        <location>
            <begin position="885"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETW84000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="975" mass="106956" checksum="5A146DD5D6C2475C" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFH8</accession>
    <name>W4KFH8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_416287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009545957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFH8"/>
    <dbReference type="GeneID" id="20673308"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_416287"/>
    <dbReference type="HOGENOM" id="CLU_3032604_0_0_1"/>
    <dbReference type="InParanoid" id="W4KFH8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW84603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="55" mass="6023" checksum="576C32E30049C3EB" modified="2014-03-19" version="1">MFGLDLILVGRETKKDFHDGFCIRTIADRFGCRALIGRSGMAFASIALLSASYPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFU4</accession>
    <name>W4KFU4_HETIT</name>
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        <recommendedName>
            <fullName evidence="8">VTT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_432945</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543650.1">
        <property type="nucleotide sequence ID" value="XM_009545355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFU4"/>
    <dbReference type="STRING" id="747525.W4KFU4"/>
    <dbReference type="GeneID" id="20674642"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_432945"/>
    <dbReference type="eggNOG" id="KOG3140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045157_0_0_1"/>
    <dbReference type="InParanoid" id="W4KFU4"/>
    <dbReference type="OrthoDB" id="3364966at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045014">
        <property type="entry name" value="TM41A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220:SF21">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 41A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="8">
        <location>
            <begin position="209"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="422"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="425"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW83921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="448" mass="48357" checksum="800977EC412B9522" modified="2014-03-19" version="1">MATLVPPAPNRHRASSTNLRPALTISTLGARQKTCSLFDPVPCTPPVGSEMAKVSSPLPSPSRLSVAVARCMELLHVDADHTYSTPSSPRSSNDDSILPLAASQNTSVDGYVQEKLSYSKPPPSRTWLQGSPSVHAPILFVITSFPVSAAIVVLAFWSLPFSVSWPRTLADCSQLGRELHGYAQSDIGHLAHVVAVISVITIWMHAWSIPGSVLWNVLAGALFSPTLATLLLAILTTVGSVFASLLSTPLAPFFMHYFPRPLALVRSALESEPEISTGSKSKSPAWVRLTILRLVGIVPWSGINIASGVCGVGLMDCLLGTFIGSLPWTAVTCQIGDILQTVASTPSPNPETISSILASPAVIFKLVFLSFLSLAPILGRDYLRSLISQADIQASSSDGLTGERISRWTWVKEWRPMVRIPSRSRSRDQLQKELEKEVSEKQQLQARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHL0</accession>
    <name>W4KHL0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_457289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542183.1">
        <property type="nucleotide sequence ID" value="XM_009543888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHL0"/>
    <dbReference type="GeneID" id="20676811"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_457289"/>
    <dbReference type="eggNOG" id="ENOG502SIZI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006410_5_0_1"/>
    <dbReference type="InParanoid" id="W4KHL0"/>
    <dbReference type="OrthoDB" id="2739948at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="635"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="150"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW85317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="654" mass="74342" checksum="6FD7F08344C34F1B" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHR1</accession>
    <name>W4KHR1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_382488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544468.1">
        <property type="nucleotide sequence ID" value="XM_009546173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHR1"/>
    <dbReference type="GeneID" id="20672121"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_382488"/>
    <dbReference type="HOGENOM" id="CLU_2831482_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHR1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW84840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="66" mass="6836" checksum="B996F2B751F9E54B" modified="2014-03-19" version="1">MTAGSLQLVLQHPSPSGGALGLLFRLGGISNLVCIDFRDKPPISIVSVSGTRRSSSANLPQSPFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4KI83</accession>
    <name>W4KI83_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_310173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542404.1">
        <property type="nucleotide sequence ID" value="XM_009544109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KI83"/>
    <dbReference type="GeneID" id="20669758"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_310173"/>
    <dbReference type="HOGENOM" id="CLU_2158748_0_0_1"/>
    <dbReference type="InParanoid" id="W4KI83"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="111" mass="12192" checksum="5194139F74EC4755" modified="2014-03-19" version="1">MLEQPGATSTPWVATGDPGFSLGVRSHSALRRILPRRPNLADPPSESHHVKVSGLGMTYQDSIFRCSRLPATSMALPMRSVGLFRSWHRLASILECFIHGHSVPCRLLAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIJ3</accession>
    <name>W4KIJ3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_379742</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>precorrin-2 + NAD(+) = sirohydrochlorin + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="2"/>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542507.1">
        <property type="nucleotide sequence ID" value="XM_009544212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIJ3"/>
    <dbReference type="FunCoup" id="W4KIJ3">
        <property type="interactions" value="111"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KIJ3"/>
    <dbReference type="GeneID" id="20671983"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_379742"/>
    <dbReference type="eggNOG" id="ENOG502RYIW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011276_8_5_1"/>
    <dbReference type="InParanoid" id="W4KIJ3"/>
    <dbReference type="OrthoDB" id="1721126at2759"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.110">
        <property type="entry name" value="Siroheme synthase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3280.10">
        <property type="entry name" value="Siroheme synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330:SF1">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="8">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="7">
        <location>
            <begin position="147"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW85672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="226" mass="24694" checksum="3732493E8CAFE642" modified="2014-03-19" version="1">MIAWQLRDKRVLVVGGGDVASGRIGHVLAAGAEVTVVSPRAGLHPATKQHIDASDRITYHDRTFVAADLDGADMVLTAIDDVAVSRAIAAQCRALRIPVNVADDPPCCDFYFGSQIRQGPLQIMISTNGRGPKLANIIRRRIEESLPRGAGEAIEKVGRLREKLKERAPGVGGDVSRRRMRWMVDLCTAWEMDELALLSEEQMERMLDEGWEKDSVLSPEALGVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIY7</accession>
    <name>W4KIY7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_457504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542619.1">
        <property type="nucleotide sequence ID" value="XM_009544324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIY7"/>
    <dbReference type="STRING" id="747525.W4KIY7"/>
    <dbReference type="GeneID" id="20676842"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_457504"/>
    <dbReference type="eggNOG" id="ENOG502QWF8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029472_0_0_1"/>
    <dbReference type="InParanoid" id="W4KIY7"/>
    <dbReference type="OrthoDB" id="2538408at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="413" mass="43908" checksum="30C8B27957116EB9" modified="2014-03-19" version="1">MLSVEQPSKPSLPTPALSRERPVRRRTAPTLRPSSPPRSPFNHALVPVPVLVPFPAFAPLSALAPLQWPVPIYAVYTSPTHPPIPNHLPTLIVTPHGQPSNILYSYLHTNFNSENYLLTPSPQGDLCVAKLFPPRPNAPNVPVKASASDPGHSAAGARVVRCEASRNLKWSITNTGVISPIYKLSLPSPDSPDLPLFQVSKPNPNAAFWSMFYFAYAGHNIPPKRIEFGKIQKNPPGPNGGGTRITISGKTPEEKAVWQTLGEGNEDCVEWVVLCAALNLLDDEIIKAAEKNPPPPAAAPMPNGAPMPGPGQGARAPVALRDPGSVPPTGGPAMQSMRGPPPQNGHPGPMGPGPGGRPPQGYPPPQGYMPGQPRPGMMPPPGGPGPAGAYPPRGPPPPQQQQQQQPQQQQRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJ74</accession>
    <name>W4KJ74_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Oligosaccharyl transferase subunit OST3/OST6 family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_432477</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OST3/OST6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542705.1">
        <property type="nucleotide sequence ID" value="XM_009544410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJ74"/>
    <dbReference type="FunCoup" id="W4KJ74">
        <property type="interactions" value="226"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KJ74"/>
    <dbReference type="GeneID" id="20674613"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_432477"/>
    <dbReference type="eggNOG" id="KOG2603">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052855_1_2_1"/>
    <dbReference type="InParanoid" id="W4KJ74"/>
    <dbReference type="OrthoDB" id="67566at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021149">
        <property type="entry name" value="OligosaccharylTrfase_OST3/OST6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692:SF0">
        <property type="entry name" value="GH11935P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04756">
        <property type="entry name" value="OST3_OST6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844313" description="Oligosaccharyl transferase subunit OST3/OST6 family" evidence="10">
        <location>
            <begin position="18"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW85897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="35284" checksum="AE5B7F85019E98E6" modified="2014-03-19" version="1">MLLSFLALLSLPVCLYAAKPSQQTHERLVKLAAENNGVIKLDTELFNLLTAPSRDWSSSIQFTALDKRRRCAPCKEFDPSFASVAKAWSYVSRNDRDKHFFATLDFDNGSPVFQKLGLTSAPVVYNYAPTEGDRKQGPGKMNPVSYDFSSGFDAEPLAIQLSALTPVPIPYRAPIDWALWGTVGTLGLAFVLAIRFLAPILRSRWTWAAITVLTSLVMTSGFMFTRIRNMPMTAANGQWIAPGFQNQYGQETTVVATIYGLLAASFLMLTLVAPLQGSPSRQRTQIYLWSGVILILFSVLVSFFRVKNRGYPFKLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJQ0</accession>
    <name>W4KJQ0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin thioesterase OTU</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_44172</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541804.1">
        <property type="nucleotide sequence ID" value="XM_009543509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJQ0"/>
    <dbReference type="FunCoup" id="W4KJQ0">
        <property type="interactions" value="223"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KJQ0"/>
    <dbReference type="GeneID" id="20675388"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_44172"/>
    <dbReference type="eggNOG" id="KOG3288">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108141_1_0_1"/>
    <dbReference type="InParanoid" id="W4KJQ0"/>
    <dbReference type="OrthoDB" id="65596at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22745">
        <property type="entry name" value="OTU_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057766">
        <property type="entry name" value="Znf-C2H2_OTU1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312">
        <property type="entry name" value="HIV-INDUCED PROTEIN-7-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312:SF0">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24560">
        <property type="entry name" value="zf-C2H2_OTU1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="7">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW86088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="199" mass="21389" checksum="1E826638A99DA723" modified="2014-03-19" version="1" fragment="single">QIVPDDNSCLFSSIAVVFEQDISKASTIRKIVADAIRNDPDTWSDAILGRPRADYISAILSPNTWGGAIELTILATHYATEIASVDVETGRVDRFTPLAGAGNRVLLIYSGIHYDAALLAPELGVPEEWCASIVPVGSDAADPNLSALKALAGKLRVKRQYTNTTTFDLKCEVCGKGLKGEKEARAHASETGHIKFGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJU8</accession>
    <name>W4KJU8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_438222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542172.1">
        <property type="nucleotide sequence ID" value="XM_009543877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJU8"/>
    <dbReference type="GeneID" id="20675029"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_438222"/>
    <dbReference type="HOGENOM" id="CLU_199928_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJU8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="56" mass="6420" checksum="731D08174BEE0C92" modified="2014-03-19" version="1">MRRESFDTPLHALKIHAQASGSIRARSITVQVAKEFDSCYVWEDQNSSMLQRASCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJW0</accession>
    <name>W4KJW0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Inositol-3-phosphate synthase</fullName>
            <ecNumber evidence="7">5.5.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Myo-inositol 1-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HETIRDRAFT_471495</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10716"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="5.5.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.4" evidence="7"/>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542922.1">
        <property type="nucleotide sequence ID" value="XM_009544627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJW0"/>
    <dbReference type="STRING" id="747525.W4KJW0"/>
    <dbReference type="GeneID" id="20677400"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_471495"/>
    <dbReference type="eggNOG" id="KOG0693">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021486_2_0_1"/>
    <dbReference type="InParanoid" id="W4KJW0"/>
    <dbReference type="OrthoDB" id="2887at2759"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000334">
        <property type="entry name" value="Inositol-3-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000069">
        <property type="entry name" value="Inositol-3-phosphate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11510">
        <property type="entry name" value="MYO-INOSITOL-1 PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07994">
        <property type="entry name" value="NAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0398">Inositol biosynthesis</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myo-inositol-1-phosphate synthase GAPDH-like" evidence="19">
        <location>
            <begin position="344"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00070063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ETW86153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="567" mass="61405" checksum="FEC5F6101F67627D" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4KK20</accession>
    <name>W4KK20_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Serine protease S53</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_122670</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542250.1">
        <property type="nucleotide sequence ID" value="XM_009543955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KK20"/>
    <dbReference type="STRING" id="747525.W4KK20"/>
    <dbReference type="GeneID" id="20666786"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_122670"/>
    <dbReference type="eggNOG" id="ENOG502QR6D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013783_3_0_1"/>
    <dbReference type="InParanoid" id="W4KK20"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF15">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845441" evidence="9">
        <location>
            <begin position="22"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="10">
        <location>
            <begin position="183"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="497"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW85386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="525" mass="56601" checksum="33AA9F37071F4F08" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KK99</accession>
    <name>W4KK99_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mRNA splicing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_380408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542909.1">
        <property type="nucleotide sequence ID" value="XM_009544614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KK99"/>
    <dbReference type="FunCoup" id="W4KK99">
        <property type="interactions" value="333"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KK99"/>
    <dbReference type="GeneID" id="20672022"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_380408"/>
    <dbReference type="eggNOG" id="KOG3407">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091076_1_1_1"/>
    <dbReference type="InParanoid" id="W4KK99"/>
    <dbReference type="OrthoDB" id="10261348at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013169">
        <property type="entry name" value="mRNA_splic_Cwf18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08315">
        <property type="entry name" value="cwf18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16528" checksum="C4B3D9A00ED3E548" modified="2014-03-19" version="1" fragment="single">MSLAQESEARKARLLALRKKRAGESTDEDSNNTSERILSSRNFDPETRTLRKRQLEDVEIEDTVEGNVKGLAEKIIAEDEERRAQDLDLFNIAPKRPNWDLKREMDKKLSKLDRQTQQAVHTLIRQRLAAQKGQSDDLVAAMQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKD2</accession>
    <name>W4KKD2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Indoleamine 2,3-dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_43434</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541782.1">
        <property type="nucleotide sequence ID" value="XM_009543487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKD2"/>
    <dbReference type="STRING" id="747525.W4KKD2"/>
    <dbReference type="GeneID" id="20674743"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_43434"/>
    <dbReference type="eggNOG" id="ENOG502QV6W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010089_2_0_1"/>
    <dbReference type="InParanoid" id="W4KKD2"/>
    <dbReference type="OrthoDB" id="540174at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF5">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="383"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW86184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="48000" checksum="3EF6C2A4B7F4333D" modified="2014-03-19" version="1">MKSLEEYDIDYATGFFPPQPLKPLEGAFELWERALEEAKRVLSLGSDVAEEAVAKQVNGEGWRERIRSLPMLDVTCFGDIRLLQRAHMVLAFLIHFYVHSQVPASDQSPIHVPACLAVPLVTVSRTLGIAPILTFADVVLWNWTPIDPELPLSATNVTFMHTLSGTATEVEFYILSARVEIRGVEMLRIIDGYVHQTDRTSLASVSKIAKDLMRLAAVVQELMEIMAKSRETVDPYIFYWNVRPWWNGSASGPDKPKWIYDGVPDSDGLDLDGPSAGQSTVMHALDVFLDVDHKLQQKRSPAPSESNKGADKGFMERMRRYMSGKHREYLADLESIPQPIRSLAKDTSIIREPYDTVVLTLKKLRDAHIRVAVLYVVTMANSIPPGSSEETARQRRTGPARGTGGNEVSTLLKAGRDATNRTMIRGNKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKD5</accession>
    <name>W4KKD5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vacuolar protein sorting-associated protein 54 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_457715</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543053.1">
        <property type="nucleotide sequence ID" value="XM_009544758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKD5"/>
    <dbReference type="FunCoup" id="W4KKD5">
        <property type="interactions" value="263"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KKD5"/>
    <dbReference type="GeneID" id="20676861"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_457715"/>
    <dbReference type="eggNOG" id="KOG2115">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003094_2_0_1"/>
    <dbReference type="InParanoid" id="W4KKD5"/>
    <dbReference type="OrthoDB" id="10259024at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012501">
        <property type="entry name" value="Vps54_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07928">
        <property type="entry name" value="Vps54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 C-terminal" evidence="8">
        <location>
            <begin position="785"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="155"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="370"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="723"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1082"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1134"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="727"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="756"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1159"/>
            <end position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW86298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1207" mass="131465" checksum="106F03790492A09A" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKX8</accession>
    <name>W4KKX8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_457468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542551.1">
        <property type="nucleotide sequence ID" value="XM_009544256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKX8"/>
    <dbReference type="GeneID" id="20676836"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_457468"/>
    <dbReference type="HOGENOM" id="CLU_1204914_0_0_1"/>
    <dbReference type="InParanoid" id="W4KKX8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="230" mass="25614" checksum="86A8FE75672AD927" modified="2014-03-19" version="1">MYGCQERRSSSAPSAMIGGTSWTLLVFLSRLLGASYRCKRCDAAREYPHRGAYTRPSCRAALMWDACSRLERPCGTAGSSFPGLPKSFQSRALPSPQSRLRTRASMALINPTSPIRQASRPFSFWPRPGPVLESLALTREAHQHLFPSHRLARPRVLQVPGSISHPRYRLALQPSTPVRTTAASARARTAKDEPCPTGKSTWILPARQSRLFSLVGSVYFIPWNPSRMHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLI9</accession>
    <name>W4KLI9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_447398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
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                <person name="Lin Y.C."/>
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                <person name="Lunden K."/>
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                <person name="Wiebenga A."/>
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                <person name="Yakovlev I."/>
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                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541220.1">
        <property type="nucleotide sequence ID" value="XM_009542925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNA9"/>
    <dbReference type="FunCoup" id="W4KNA9">
        <property type="interactions" value="628"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KNA9"/>
    <dbReference type="GeneID" id="20668840"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_239926"/>
    <dbReference type="eggNOG" id="KOG2496">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022620_4_0_1"/>
    <dbReference type="InParanoid" id="W4KNA9"/>
    <dbReference type="OrthoDB" id="340962at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20524">
        <property type="entry name" value="CYCLIN_CCNH_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20525">
        <property type="entry name" value="CYCLIN_CCNH_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
        <property type="entry name" value="Cyclin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="70"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="296"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW87303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="342" mass="38657" checksum="3E503E7DB9524D9B" modified="2014-03-19" version="1" fragment="single">SLKKPLYSSSTQYNNWRFSPTQLRSIRSSLNAAAVTAIRNTFETNSPGSSSDIQFLTAEEEHLLVRLYITKISQLCGHFHFPEEVEATAVSYLKRFYLKNTVMDWHPKNVMCVNCSLPQATWLTALFLATKTTNHPISLEAYTSNIPRTVPSDVLDLEFLIAQSLAFEFAVWHTHRALWGLWLDVQDLPDSPSRDILQEAYDTALRHVRTSRITDAELIYTPSQIALACLSIAHPDLAAVWARSKGVEPINSIKQMILQDGDIPSVEVVREIDRRLKLCKNPEKIVGSKAYLAKKEKDEREASEKRAKKAEEVRKAMENGDPFGNELDVETHSIAALDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNH2</accession>
    <name>W4KNH2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartate aminotransferase</fullName>
            <ecNumber evidence="8">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_437828</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="8"/>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541187.1">
        <property type="nucleotide sequence ID" value="XM_009542892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNH2"/>
    <dbReference type="FunCoup" id="W4KNH2">
        <property type="interactions" value="517"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KNH2"/>
    <dbReference type="GeneID" id="20674986"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_437828"/>
    <dbReference type="eggNOG" id="KOG1411">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032440_1_2_1"/>
    <dbReference type="InParanoid" id="W4KNH2"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006533">
        <property type="term" value="P:L-aspartate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000026">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF22">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="49"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW87264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="425" mass="46195" checksum="DF44C23F63749C63" modified="2014-03-19" version="1">MLAIARSQAARGSFALRAASVSTWSHVPAGPPDPILGVSEAFKADKDARKINLGVGAYRDGNGKPYVLSAVKKAEEALRAANPDKEYLPITGLADFTKNAAKLAYGDDSAPLKENSIAITQSISGTGALRIGGAFLARFYPHSKIIYLPVPSWGNHTPIFRDSGLEVRGYRYFDKSTVGLDFAGLKEDLKNAPEKSIVLLHACAHNPTGIDPTAEQWAEISDIVKEKQLFPFFDMAYQGFASGSTTRDAFAVRHFVSQGHQVALSQSFAKNMGLYGERVGAFSLTTASPEEKARVDSQLKIVIRPMYSNPPLHGARIANTILSKPELYTEWESEVKGMADRIISMRARLYDALTHTHKTPGEWGHIKSQIGMFSFTGLSPPQTKALAEKAHIYMTADGRISMAGLNANNIDYFAESVDKAVKGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNK6</accession>
    <name>W4KNK6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Delta 8-(E)-sphingolipid desaturase</fullName>
            <ecNumber evidence="5">1.14.19.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HETIRDRAFT_431762</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">TC 32-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.18" evidence="5"/>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541321.1">
        <property type="nucleotide sequence ID" value="XM_009543026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNK6"/>
    <dbReference type="STRING" id="747525.W4KNK6"/>
    <dbReference type="GeneID" id="20674561"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_431762"/>
    <dbReference type="eggNOG" id="KOG4232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016265_3_1_1"/>
    <dbReference type="InParanoid" id="W4KNK6"/>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF30">
        <property type="entry name" value="DELTA 8-(E)-SPHINGOLIPID DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="16">
        <location>
            <begin position="6"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETW87418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="524" mass="59582" checksum="F9C8FE1E44AD3A8E" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNV7</accession>
    <name>W4KNV7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_437723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541015.1">
        <property type="nucleotide sequence ID" value="XM_009542720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNV7"/>
    <dbReference type="STRING" id="747525.W4KNV7"/>
    <dbReference type="GeneID" id="20674975"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_437723"/>
    <dbReference type="eggNOG" id="ENOG502SJZX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040700_0_0_1"/>
    <dbReference type="InParanoid" id="W4KNV7"/>
    <dbReference type="OrthoDB" id="3258408at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="382" mass="41970" checksum="820DAA7CE57638AE" modified="2014-03-19" version="1">MSFQNFRLDGVPIPPIPQQPPQPPQTFTPHQYSPPAQSGPVLGPLSEPPQFQLQTVDGSVRGSNRGPYGSGDMNDGYTLVFENMNAFEAWRAKEEEEKMVEFVKGDTHGSKAVPPRFKDHVKLVCARHSRSGRKKYVKKFPDRVRKVPSRKLEGKGCPASISYKTYFETDEIRVCYFSQHSHETGLSNLPYTRRGRRAAAAGASPQAGLVDGASVPQPIASTSSIGHALTPAQPAQYLTASMVAAGSPPMRAQPPQHPNGFTSYPHFPSMSMPAPPGLGSVPPPSDQTDRGRIERERWDRFETLFQSIRGHARHFEYPPPSVAALESVLMRMYFESPIQTPAQPIQMMVPPTQQQQALPTPAGPTPMEDGRSESGSGEEEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPF5</accession>
    <name>W4KPF5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_377595</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540885.1">
        <property type="nucleotide sequence ID" value="XM_009542590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPF5"/>
    <dbReference type="FunCoup" id="W4KPF5">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="GeneID" id="20671892"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_377595"/>
    <dbReference type="eggNOG" id="KOG1726">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061852_1_0_1"/>
    <dbReference type="InParanoid" id="W4KPF5"/>
    <dbReference type="OrthoDB" id="434647at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="185"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW86921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="219" mass="24099" checksum="74C0FBA27361F02F" modified="2014-03-19" version="1">MLMSLLSRLLTGWFAFLLPSYSTFKALKHRPISEPELERWTTYWAVVGAFVAFEYGAEWLLSWFPFYWEIKTAFLLYLSLPQLQGSSFIFKNYLEPFYGSHEADIDAGIASAQTETLAFAQTRLASLWEIVWSIISKTPVSAKGTGPEENGHPAGQQSPLQAVQGLWNAFGPAVLGSVKPANGQLATPAASSTSVEPSINGYNVDSRAPHTPEPEPQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPH1</accession>
    <name>W4KPH1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_59902</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540424.1">
        <property type="nucleotide sequence ID" value="XM_009542129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPH1"/>
    <dbReference type="FunCoup" id="W4KPH1">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="GeneID" id="20678490"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_59902"/>
    <dbReference type="eggNOG" id="KOG2262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004965_1_1_1"/>
    <dbReference type="InParanoid" id="W4KPH1"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="393"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="452"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="595"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="625"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="663"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="708"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW87743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="779" mass="88141" checksum="4DC6C70F95711A42" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JM44</accession>
    <name>W4JM44_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6697 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_120701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553102.1">
        <property type="nucleotide sequence ID" value="XM_009554807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JM44"/>
    <dbReference type="GeneID" id="20666709"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_120701"/>
    <dbReference type="HOGENOM" id="CLU_1354776_0_0_1"/>
    <dbReference type="InParanoid" id="W4JM44"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046520">
        <property type="entry name" value="DUF6697"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20411">
        <property type="entry name" value="DUF6697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6697" evidence="2">
        <location>
            <begin position="93"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW74598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="202" mass="23068" checksum="FF21F7869F706C94" modified="2014-03-19" version="1">MGHSSKCLSTTQNRTEKSTDIDPITPTKQDGHKQPPGKLGDTDVSLPVKDIPDHFPPTVPLHLIRRYFSLAYRSKMDPYSGVPLIGTDHTVWWRMLFVAKGLNFGVPAAPGKDGLLLSNVTQMNNPEEVAVWAEDNRSDWIYYGQYVVTGSDGRLSKEEFSRLSERVRKNWADLIVRQCYWGIDISLHHQNMVRDLTQCYHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMC8</accession>
    <name>W4JMC8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Protein transport protein BOS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_437271</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">SNARE required for protein transport between the ER and the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 11">Belongs to the BOS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553177.1">
        <property type="nucleotide sequence ID" value="XM_009554882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JMC8"/>
    <dbReference type="FunCoup" id="W4JMC8">
        <property type="interactions" value="588"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JMC8"/>
    <dbReference type="GeneID" id="20674942"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_437271"/>
    <dbReference type="eggNOG" id="KOG3251">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078260_0_0_1"/>
    <dbReference type="InParanoid" id="W4JMC8"/>
    <dbReference type="OrthoDB" id="158360at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15863">
        <property type="entry name" value="SNARE_GS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027027">
        <property type="entry name" value="GOSR2/Membrin/Bos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF1">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028865">
        <property type="entry name" value="Membrin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="97"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR028865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW74683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="236" mass="27036" checksum="571F24DA0DABBCC8" modified="2014-03-19" version="1">MNSLYTLGVRQTSSIQADLERLRGGDSSASLLGQVSASLSAMNRTIDDYDSMARREMIKAKQEKAVVRVQKFRTDYFELRKEFERLKTQAEVEQRAELFSGTNPLSPGASDARRRFTPSAPPNAPEHTESPFRTPEPFMAATREQHALHEHSFLQNTDTRLDEFIAQGREVLDNLVDQRNMLKGTQRRLLDAANTLGLSRDVIGWIERRSTQDMYIFIAGAVFTFFCFYLIWRYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMK3</accession>
    <name>W4JMK3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_108517</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553247.1">
        <property type="nucleotide sequence ID" value="XM_009554952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JMK3"/>
    <dbReference type="GeneID" id="20666353"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_108517"/>
    <dbReference type="HOGENOM" id="CLU_571137_0_0_1"/>
    <dbReference type="InParanoid" id="W4JMK3"/>
    <dbReference type="OrthoDB" id="3215335at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="3">
        <location>
            <begin position="38"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="40"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW74763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="478" mass="51791" checksum="31009B283A9234DF" modified="2014-03-19" version="1">MDSPTRSFEHPSWTALSTRQSASPVNPPPQQAQPSTSSAPARRFKRLTEPGRQILTDFYANETHYPSLEQKHALLDRLRAAGVEYHMTNLNAWFTNRRKKQSPTLSSRDLLWPSITQEKEKKIQTLLHDFPQPSRDMINAWATVVSAQPEHIILYIQHMAYSMEHHLPLATTPAHPATASFASIVAASNAHLARRPSAHSSPSFALRPVDSPMDIDSPDDDSLEADPAHLPTPSVSTSPEPAPRSSARPHLTPIQTAMSASPTPPPSMSTISSSPHGYTRRGCSPTTAPTTSLGTRDPISPVSAITTPRIPRPSSFVLPRPESFGRPRPGMLDSPAVSDQRTNQAPLSPPPTATVTEPPTPVTAADLSLLSPLERIRAMRRASFQLSGDATSSPILPPSISRAGGSHPSAVATTTTTATTSTTTYVPFLPPLPAEAPKTPAEFAAALRPYADYQQSFIRRVKNGELRAYGFTPEMVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMP9</accession>
    <name>W4JMP9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pali-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_164958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553297.1">
        <property type="nucleotide sequence ID" value="XM_009555002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JMP9"/>
    <dbReference type="GeneID" id="20667952"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_164958"/>
    <dbReference type="eggNOG" id="ENOG502SP7Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076420_1_0_1"/>
    <dbReference type="InParanoid" id="W4JMP9"/>
    <dbReference type="OrthoDB" id="3881at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF4">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW74822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="29294" checksum="46EACBF65571E4AF" modified="2014-03-19" version="1">MAWFQRRRYQNGSQPQPYVPQPYNPQLPVPLSHHRHHQHRRERGHTGGTTFLLLCAFILFLLVALSLPIIKPIYLLQLDGIITNNQPETSIGTQVRFGVWGLCVTSALDQPTLFTNDGVCIGPRLGYTVDPSILSLIGNEQLISIVLKGVTILLILHPIAAGLSLATLIPILLSCCCGHHAAWILSLIASIVTAIVSSVVLAADLALVIIARNKVKDLALGTFDVKFGNGVWMMVAGVALIWLCVILLSARACYCCGFRRKYDYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4JN87</accession>
    <name>W4JN87_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_423596</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW75003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553455.1">
        <property type="nucleotide sequence ID" value="XM_009555160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JN87"/>
    <dbReference type="STRING" id="747525.W4JN87"/>
    <dbReference type="GeneID" id="20673915"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_423596"/>
    <dbReference type="eggNOG" id="KOG1812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022048_7_6_1"/>
    <dbReference type="InParanoid" id="W4JN87"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="152"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW75003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="455" mass="50256" checksum="F70C9530676C274E" modified="2014-03-19" version="1">MSISSPPPAAGPSHVASPHAKRDTNALSDLVDRLSVISEPDQESAHGPLTDAQLALNLYAEELELSTLIAQLALEDIAELQGQQKGKGREGAPASDAALALELCAEEAQLCIGFQNDHLLALKTHVDEHGTSFLADEIKVPQTAKPDPPRPKNTSCVICRDPINGVNIHTPCGHDYDVGCIADLFAACTRDESLYPPRCCHQNIPLLSVREHLGKDLLSLFVQKSREFETQKRVYCARQDCSSFVGAEHSNGAAAPVALPCSAAGCDTLTCSRCKSQVNRTGTHICVVDPSASDRVVLDLARESGWSQCPGCSRLIELNTGCYHITCFCKADFCYLCRARWKTCTCPQWEERLLYAAAEQRVDRMLGGVRAPEPAVRIDPQPQPQIRAHVAERRERLIRDAVDDLRYNHECGHNGWTFRNGRGQCESCFYTLPQYLFRCRGCQMLACNRCRRNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNN9</accession>
    <name>W4JNN9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hybrid ascorbate-cytochrome C peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_108266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552551.1">
        <property type="nucleotide sequence ID" value="XM_009554256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNN9"/>
    <dbReference type="GeneID" id="20666328"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_108266"/>
    <dbReference type="HOGENOM" id="CLU_1938440_0_0_1"/>
    <dbReference type="InParanoid" id="W4JNN9"/>
    <dbReference type="OrthoDB" id="2144714at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004843787" evidence="1">
        <location>
            <begin position="24"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="130" mass="14087" checksum="F0EEF9FDA1013C68" modified="2014-03-19" version="1">MRAHISPLFLLLLPQNLIFSSFAFAPNPILVSNELEHLLVDTGGANDGGFKRAITPCTNYVEGSQLLGWETAAQWIRVAFHDFVTADVGTGVGGLDASIGFETLRAENSGTAMNDSLTFFAPFVNAQWRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JP16</accession>
    <name>W4JP16_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_108112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552729.1">
        <property type="nucleotide sequence ID" value="XM_009554434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JP16"/>
    <dbReference type="GeneID" id="20666313"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_108112"/>
    <dbReference type="HOGENOM" id="CLU_120096_0_0_1"/>
    <dbReference type="InParanoid" id="W4JP16"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004843794" evidence="2">
        <location>
            <begin position="24"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW75297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="190" mass="19288" checksum="E93346945DBA763A" modified="2014-03-19" version="1">MFSLVKLTTFVTITFGAIAAVSAAAVQTKRQSDSLIAILAELTAQLAPAAAQLSSLDANNATAENITPIVSSITSNVQSSQSKISALPTQDTNFVSSDDVASGLNGVFQTVLSPASNVMALPGVDSAKVGPAFLPLGVVLDGLVIAVFSVVVDLVVVVKATLDTLLVGVVHVILDLKFTTLIATLGLGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPF3</accession>
    <name>W4JPF3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Non-catalytic module family EXPN protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_108072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552773.1">
        <property type="nucleotide sequence ID" value="XM_009554478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPF3"/>
    <dbReference type="STRING" id="747525.W4JPF3"/>
    <dbReference type="GeneID" id="20666310"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_108072"/>
    <dbReference type="eggNOG" id="ENOG502S6X4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047639_6_2_1"/>
    <dbReference type="InParanoid" id="W4JPF3"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="RlpA-like protein double-psi beta-barrel" evidence="2">
        <location>
            <begin position="48"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW75344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="117" mass="12042" checksum="87D60ACC3F0C0F6A" modified="2014-03-19" version="1">MAVSVSAAPAQLSRRDFSGQGTFYVPGLGACGVTNTGSDLIVAISAARFDSTGTANPNLNPLCGKRITANFQGKSVTATVVDRCPGCAVNDLDFSPAAFDALADPSLGRIDISWNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPL4</accession>
    <name>W4JPL4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Nucleoporin protein Ndc1-Nup</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_107932</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NDC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552923.1">
        <property type="nucleotide sequence ID" value="XM_009554628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPL4"/>
    <dbReference type="STRING" id="747525.W4JPL4"/>
    <dbReference type="GeneID" id="20666291"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_107932"/>
    <dbReference type="eggNOG" id="ENOG502S8WN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026454_0_0_1"/>
    <dbReference type="InParanoid" id="W4JPL4"/>
    <dbReference type="OrthoDB" id="67850at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070631">
        <property type="term" value="P:spindle pole body localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019049">
        <property type="entry name" value="Nucleoporin_prot_Ndc1/Nup"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269:SF6">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09531">
        <property type="entry name" value="Ndc1_Nup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW75517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="681" mass="75402" checksum="AE3994158B770E05" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPR7</accession>
    <name>W4JPR7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_164306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPR7"/>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_164306"/>
    <dbReference type="HOGENOM" id="CLU_2399951_0_0_1"/>
    <dbReference type="InParanoid" id="W4JPR7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW75567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="93" mass="10251" checksum="156251443E80E73D" modified="2014-03-19" version="1">MGSCEIPHTEDTPSGELSEEFQVTFFTPPKCSILYIACWRIVAVSISSAVVGRGEQGYSDLRLVYVRWLDNLSPTASNMPLAQWLCSAKSYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPU4</accession>
    <name>W4JPU4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_412378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552557.1">
        <property type="nucleotide sequence ID" value="XM_009554262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPU4"/>
    <dbReference type="GeneID" id="20673024"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_412378"/>
    <dbReference type="HOGENOM" id="CLU_1796730_0_0_1"/>
    <dbReference type="InParanoid" id="W4JPU4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="144" mass="16291" checksum="02CFC6C4938860E8" modified="2014-03-19" version="1">MTGEGGRYKSRKGLIVHEGYKCQTTRSYNDRGDESTGPRPSPLARAIGCTNRKTGRGQDKREQRLHRDRAKLDIHRSRHLSSPPTLMSVESRDDDEGTNEACSVAEDLDIKSLRADNRQSKRRGNTARKGEDVTVRGERDEPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPV3</accession>
    <name>W4JPV3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_456092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552909.1">
        <property type="nucleotide sequence ID" value="XM_009554614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPV3"/>
    <dbReference type="GeneID" id="20676695"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_456092"/>
    <dbReference type="HOGENOM" id="CLU_587996_0_0_1"/>
    <dbReference type="InParanoid" id="W4JPV3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="524" mass="57978" checksum="63316D490216324C" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQR3</accession>
    <name>W4JQR3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="9">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_442258</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="9"/>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552051.1">
        <property type="nucleotide sequence ID" value="XM_009553756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQR3"/>
    <dbReference type="FunCoup" id="W4JQR3">
        <property type="interactions" value="633"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JQR3"/>
    <dbReference type="GeneID" id="20675429"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_442258"/>
    <dbReference type="eggNOG" id="KOG2467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022477_0_1_1"/>
    <dbReference type="InParanoid" id="W4JQR3"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000050">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF35">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="10">
        <location>
            <begin position="15"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW75799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="477" mass="52353" checksum="45E768724B048C91" modified="2014-03-19" version="1">MASTPEFNKSLYAPLSEIDPVVQNIIDKETWRQYSGLELIASENLTSRATMEANGSILTNKYSEGLPNARYYGGNEYIDELEVLCRKRALEAFHLDPAKWGVNVQPYSGSTANFAALTALLQPQDRLMGLGLPDGGHLTHGYYTAKKKMTASSIYFQSLPYGLDPATQLIDYEGLAKQARIFKPRLLICGASAYPRDWDYPALRKVADEHSAYLMADIAHTSGLVAAQELADPFEYCDVVTTTTHKTLRGPRAGLIFFRKDGENHKDLEKRVNDAVFPACQGGPHNNTIAGIATALLQASQPSWKAYAQQVVKNARALADELVKNGYKLQTGGTDNHLVLWDLRPLGLTGSKVEKVGDLLGITINKNAVSGDASAQVPGGIRLGTSALTSRNMLEDDVRQVARFLHRSVQLSLLLQKEAGSKLLKDFVRVATTPQEGKEGARLVKELKKEVTTFARRWPVPGIEGEIKRPAGVEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQW9</accession>
    <name>W4JQW9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_106510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552101.1">
        <property type="nucleotide sequence ID" value="XM_009553806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQW9"/>
    <dbReference type="GeneID" id="20666167"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_106510"/>
    <dbReference type="HOGENOM" id="CLU_927682_0_0_1"/>
    <dbReference type="InParanoid" id="W4JQW9"/>
    <dbReference type="OrthoDB" id="3328833at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="300" mass="34323" checksum="DDDD60A455C08BC9" modified="2014-03-19" version="1">MAKDKINPVSHSCPQPATSKQLSTLQLVLIFVSLVMDIVFGYLANEIWLRDYAREHEYSIDSDSAYLARYHESSHPFVIRLDELEGMREAARNLIAQSGIHASLKTVWISNCKSCFCWSIPQTFRADRRTPQTSECLERFKNLVGAKGEPSYWTTIDGDVPENMLHQAKPKKEHWQMSLESFDGGRMPIKYIGALTEKDPDKVERTLARQRANDLRPFFTADDFLDMYNNWRGVRSGCGIWRKISNAEVQIGIEDEEEILFQMNKERVSAVALEQWIWAENQLVADSGISTSPSHAVLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRP1</accession>
    <name>W4JRP1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_430508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552351.1">
        <property type="nucleotide sequence ID" value="XM_009554056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRP1"/>
    <dbReference type="GeneID" id="20674453"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_430508"/>
    <dbReference type="HOGENOM" id="CLU_1115872_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRP1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844922" evidence="2">
        <location>
            <begin position="22"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW76134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="249" mass="27073" checksum="2811015CB2CCAA0C" modified="2014-03-19" version="1">MIFTALSTLLRLWRNAHDADADSDAESVDVDWVARTGTTPVIVTVTPPTPTHPRPRPYTADAAFQDAYGRDSLWLPRTPRPPPYAGRARYSWPPPYPGQSRYADLPPSYTADPERAFPKPPSPAAFPAGAIPSSSTAPPFPITSSEADATQTPATLCRIIFNLGWICPLVWLLAIPFLLVPHLPFPLPQALTPYGPLTPLRLATERHWAKRSLSAFSSLSTLAGIAVAVFYMAHHHPHPHDPAGASLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRV3</accession>
    <name>W4JRV3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_422622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552477.1">
        <property type="nucleotide sequence ID" value="XM_009554182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRV3"/>
    <dbReference type="GeneID" id="20673829"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_422622"/>
    <dbReference type="HOGENOM" id="CLU_2469375_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRV3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="88" mass="9456" checksum="38A76F27F1D70E2F" modified="2014-03-19" version="1">MTCTDLTHHRTPFNHTEATIKGSSHTGKVYRDSGACCLPLGPVTLGLCCMATHALSVVLLHLGIDYVALSQTFLSSPHALRNHQTSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4JS60</accession>
    <name>W4JS60_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-trimethyl-L-lysine(9) demethylase</fullName>
            <ecNumber evidence="2">1.14.11.66</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_105882</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:60200"/>
            <dbReference type="Rhea" id="RHEA-COMP:15538"/>
            <dbReference type="Rhea" id="RHEA-COMP:15542"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.66"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the JHDM3 histone demethylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.66" evidence="2"/>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551312.1">
        <property type="nucleotide sequence ID" value="XM_009553017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JS60"/>
    <dbReference type="STRING" id="747525.W4JS60"/>
    <dbReference type="GeneID" id="20666108"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_105882"/>
    <dbReference type="eggNOG" id="KOG0958">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001442_1_0_1"/>
    <dbReference type="InParanoid" id="W4JS60"/>
    <dbReference type="OrthoDB" id="9547406at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051864">
        <property type="term" value="F:histone H3K36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140684">
        <property type="term" value="F:histone H3K9me2/H3K9me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF7">
        <property type="entry name" value="[HISTONE H3]-TRIMETHYL-L-LYSINE(9) DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13771">
        <property type="entry name" value="zf-HC5HC2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="8">
        <location>
            <begin position="183"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="9">
        <location>
            <begin position="484"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="734"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="110"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="280"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="364"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="670"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1168"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="675"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="702"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1181"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1202"/>
            <end position="1215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW76397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1237" mass="134359" checksum="FA06C7F9E155B9D5" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTE3</accession>
    <name>W4JTE3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromatin modification-related protein EAF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_430103</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MRG family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551659.1">
        <property type="nucleotide sequence ID" value="XM_009553364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTE3"/>
    <dbReference type="FunCoup" id="W4JTE3">
        <property type="interactions" value="416"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JTE3"/>
    <dbReference type="GeneID" id="20674414"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_430103"/>
    <dbReference type="eggNOG" id="KOG3001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039566_1_1_1"/>
    <dbReference type="InParanoid" id="W4JTE3"/>
    <dbReference type="OrthoDB" id="124855at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038133">
        <property type="entry name" value="HAT_Nua4_EAF3/MRG15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="9">
        <location>
            <begin position="23"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="93"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW76788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="309" mass="35005" checksum="95E224BC222ECBCE" modified="2014-03-19" version="1">MAGPSSSVYNVNEKVLCYHGPLIYEAKVLKVEHWDETTTKLGSVGPHYLVHYRGWKQTWDEWVPPQRLLKFNEVNIALQKSLIQSSKEIAAQSTNAKASATTKAQPVGRRKEGRGTKRGRDDDDGTRRPELRLVIPEILKVLLVDDWEAVTKNNQLVTLPRNPSVKDILTDFQNSVLASPAPQLRDPTTVLPTIIAGLQTYFDRALGANLLYCFERPQYADIRKRYVTGPTVQVGQEREMSAVYGAEHLLRMIVSLPQMVAGSTMDPESVALVRHYVTELMNYMIKERDQIFQTKYDSASLQYQNVSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4JU11</accession>
    <name>W4JU11_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_454455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009552302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JU11"/>
    <dbReference type="GeneID" id="20676518"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_454455"/>
    <dbReference type="eggNOG" id="ENOG502S1RP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150802_0_0_1"/>
    <dbReference type="InParanoid" id="W4JU11"/>
    <dbReference type="OrthoDB" id="5366606at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW77043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="149" mass="16146" checksum="E009B167903A63CD" modified="2014-03-19" version="1">MSFSLRIQHGITGGFAPPRPSAVHELSLDPSIAPTSILLASSLRPDGTPHLQSHPPKSVPLSATTTALLDELRSILHRLPTENPPSSDIYHRDIGIMWQSDDLTWFNSAPQGCARFDSDVAPTEDDKKAFDRAVEIVDALVKSGVAQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUL2</accession>
    <name>W4JUL2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_326831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009552483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUL2"/>
    <dbReference type="GeneID" id="20671272"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_326831"/>
    <dbReference type="eggNOG" id="ENOG502SXYS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068189_0_0_1"/>
    <dbReference type="InParanoid" id="W4JUL2"/>
    <dbReference type="OrthoDB" id="128646at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="45933" checksum="6FBC604A6ECF55A7" modified="2014-03-19" version="1">MKTRGAPSLRIETELIGKNRKAATQALVDSGATGIFMHPNFVERHGIRTQRTPHPIPVNTVQNTEFKGGPITRFAELKLRVLGEQGGAHIESARFYIAEIGKEDVILGTDWLLEHNPEVDWHAYGLHFTRCPPTCDIIGGPVKAKRAFRKPGRQEPGVRRMVTVPRERDYSIPLQKPGKGQLGRKVGNTTVPHPRILPKIRGSQPKGTNREYSLRTQARNYMAPTWAEEEPQEGGGPLSALPSTDLDEDGVYLVRYLETGQLEALELYNDREEGYDIHRVETSVANTPARKAEPAKAAIGKQTKHTNSQKLAEEASKGKPELSFEEIVPKVYWSYRKVFEGRKPGKLPPKRPWDHKIELKDDIEHSLRPKLYSLSPMEQEELKKFIDESLKKGFIRESKSHMASPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUQ2</accession>
    <name>W4JUQ2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_430105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
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                <person name="Asiegbu F."/>
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                <person name="Bouzid O."/>
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                <person name="Lind M."/>
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                <person name="Yakovlev I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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                <person name="Yakovlev I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <feature type="non-terminal residue" evidence="2">
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77843.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="57" mass="6144" checksum="4A322AE558B4BFD9" modified="2014-03-19" version="1" fragment="single">CIPVNIRALQERERVRLLLAASQYLGVSIGSRPETGSHHGLAHQNGKRPGSFSPIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWL8</accession>
    <name>W4JWL8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SANT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_388003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549960.1">
        <property type="nucleotide sequence ID" value="XM_009551665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWL8"/>
    <dbReference type="STRING" id="747525.W4JWL8"/>
    <dbReference type="GeneID" id="20672340"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_388003"/>
    <dbReference type="eggNOG" id="KOG1878">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1086316_0_0_1"/>
    <dbReference type="InParanoid" id="W4JWL8"/>
    <dbReference type="OrthoDB" id="10258692at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051571">
        <property type="entry name" value="N-CoR_corepressor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992">
        <property type="entry name" value="NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992:SF39">
        <property type="entry name" value="SMRTER, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW77947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="32091" checksum="845DE210C241328F" modified="2014-03-19" version="1" fragment="single">MQEELQEALIGDTVVETSLKPVDLIVNQPPDQLLQQLPMPVVPSNFVPFVGEARSLQEALRVVVAARQQFDHQSREERVDPVLLSNKAIAEQPPASSTSPETLIQAMMTGERGAVRLRRFHELRPTLVQRIAERQETVEEKTKRLRKEYTELHDSWVAHCALLDSQGQTNPGDEMATVSGRTTRRSAAVLGDAVRSDLEMEQIIASLGNEDLTDPAHLALRNIAVIPDMISVTHGRVDALFDDTNNLVENPAAFYDPSPSVAAWTDEEQQEFFEKFAAHPKQFGIIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWM9</accession>
    <name>W4JWM9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA mismatch repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_157347</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549874.1">
        <property type="nucleotide sequence ID" value="XM_009551579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWM9"/>
    <dbReference type="FunCoup" id="W4JWM9">
        <property type="interactions" value="741"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JWM9"/>
    <dbReference type="GeneID" id="20667719"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_157347"/>
    <dbReference type="eggNOG" id="KOG0217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_1_0_1"/>
    <dbReference type="InParanoid" id="W4JWM9"/>
    <dbReference type="OrthoDB" id="121051at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="9">
        <location>
            <begin position="1044"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="804"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW77854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1220" mass="135601" checksum="2C59494E106EF338" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXJ4</accession>
    <name>W4JXJ4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_411111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549810.1">
        <property type="nucleotide sequence ID" value="XM_009551515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXJ4"/>
    <dbReference type="GeneID" id="20672921"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_411111"/>
    <dbReference type="HOGENOM" id="CLU_2455004_0_0_1"/>
    <dbReference type="InParanoid" id="W4JXJ4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW77780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="89" mass="9799" checksum="EF28BE2D4760E092" modified="2014-03-19" version="1">MADDESVGGVQGGDCDYGVYQHSGSQRKMSKTERTKVKVGMYGSHRDCRVVMLIKALKDLKQIPDKRSINLARADPGHDVKTEYGLKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXK8</accession>
    <name>W4JXK8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 monooxygenase 97</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cpm97</name>
        <name evidence="10" type="ORF">HETIRDRAFT_411352</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550273.1">
        <property type="nucleotide sequence ID" value="XM_009551978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXK8"/>
    <dbReference type="STRING" id="747525.W4JXK8"/>
    <dbReference type="GeneID" id="20672946"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_411352"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_25_0_1"/>
    <dbReference type="InParanoid" id="W4JXK8"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF50">
        <property type="entry name" value="BIFUNCTIONAL ALBAFLAVENONE MONOOXYGENASE_TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844147" evidence="9">
        <location>
            <begin position="18"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW78292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="494" mass="54900" checksum="AE4DFFDFD9C05869" modified="2014-03-19" version="1">MALIIAVSCSFLALPMFSPLSPFGAIFPNNRANPGSSWSWSSKTSYLNHTRDVISMVPIFPGTPCYYTNSVDVMKQILGNESKLNLVKPQDLTLARILGDSLSSASGDVWRRHRRVVAPAFTNKIFSSVWKEARAVYDQMLQAEGWSLQTDIMFVEAHSFLLKFTFMIISKCGFGFATSWSPPESGAMAFPEALRVVSEIIVPRMVLPSWAYKLPVKSLRRIGDAWSIVASFISASIDTRRNDQMDGADLDDASLPGDILNRLVASSLGTQKYSLSEQEVVANMFSLMFAGHETTASGLMSTFVYLALYQDEQDKAFQEVKAAFGTHNLSELIDSSQLSRTLACFLEAQRLCPAALFFPREMTEDVPIAVARPTASTVVLKKGALMIFDLIAMFRNPYLFQDPDRFCPERWIGASEQEVGMFGMGPRACVGRKFAQVEALAILASFLFDWKFEPVLGEGETAEKYEERAMGCARLSGTAFTFDRIPLRLVKRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXK9</accession>
    <name>W4JXK9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_107456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549827.1">
        <property type="nucleotide sequence ID" value="XM_009551532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXK9"/>
    <dbReference type="GeneID" id="20666248"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_107456"/>
    <dbReference type="HOGENOM" id="CLU_839539_0_0_1"/>
    <dbReference type="InParanoid" id="W4JXK9"/>
    <dbReference type="OrthoDB" id="10677533at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW77800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="331" mass="34529" checksum="5A7B20A914313F13" modified="2014-03-19" version="1">MNMIYASDPALKYEPLSAWNSTNPKTNQTGSTVSVQFQGKSPIRSPAKVVKSEVAVAPGTTLKAFGKTELPSIFYSEDDHQIHNQSISAHEEKDSVMILELSYHECSNHAVKLIVFNSAEQGHGLAISKFEYTPCTPNITLAQPSIPYTPIVPPATPAAQSTSPSTSSVSSSSSSSNDTAQTVGIAIGCVLGALLILSVAGLLWQAPHPSGPPKLTALRADLPPHFPSSALSKYAPAADSRALFSVEVIAPSRDEKSELPAPAIRPVEGTSGAAYLRGYLPDSKEWLRNAERARVAAAAAAAAQSAHGEPGGHAAAYEGGIAGGNGERPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYM6</accession>
    <name>W4JYM6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_459856</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the WD repeat coronin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548889.1">
        <property type="nucleotide sequence ID" value="XM_009550594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYM6"/>
    <dbReference type="FunCoup" id="W4JYM6">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JYM6"/>
    <dbReference type="GeneID" id="20677026"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_459856"/>
    <dbReference type="eggNOG" id="KOG0303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026859_3_2_1"/>
    <dbReference type="InParanoid" id="W4JYM6"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000502">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF0">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="9">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="84"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="142"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="186"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="411"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="477"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW78554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="527" mass="56926" checksum="B4CECFF400335640" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZ53</accession>
    <name>W4JZ53_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Dihydroxyacetone kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_64180</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548809.1">
        <property type="nucleotide sequence ID" value="XM_009550514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZ53"/>
    <dbReference type="FunCoup" id="W4JZ53">
        <property type="interactions" value="401"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JZ53"/>
    <dbReference type="GeneID" id="20678672"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_64180"/>
    <dbReference type="eggNOG" id="KOG2426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017054_6_0_1"/>
    <dbReference type="InParanoid" id="W4JZ53"/>
    <dbReference type="OrthoDB" id="1724672at2759"/>
    <dbReference type="UniPathway" id="UPA00617">
        <property type="reaction ID" value="UER00669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019588">
        <property type="term" value="P:anaerobic glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.340:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF14">
        <property type="entry name" value="DIHYDROXYACETONE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="12">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="11">
        <location>
            <begin position="324"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW78848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="55912" checksum="A5BF3909C56A2B62" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZ83</accession>
    <name>W4JZ83_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_479539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the rtf2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550365.1">
        <property type="nucleotide sequence ID" value="XM_009552070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZ83"/>
    <dbReference type="FunCoup" id="W4JZ83">
        <property type="interactions" value="751"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JZ83"/>
    <dbReference type="GeneID" id="20677875"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_479539"/>
    <dbReference type="eggNOG" id="KOG3113">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048955_2_0_1"/>
    <dbReference type="InParanoid" id="W4JZ83"/>
    <dbReference type="OrthoDB" id="247013at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006274">
        <property type="term" value="P:DNA replication termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16653">
        <property type="entry name" value="RING-like_Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006735">
        <property type="entry name" value="Rtf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027799">
        <property type="entry name" value="Rtf2_RING-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775">
        <property type="entry name" value="PROTEIN C20ORF43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775:SF0">
        <property type="entry name" value="REPLICATION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW78390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="305" mass="33264" checksum="41289536F86D1895" modified="2014-03-19" version="1">MGNDGGSIPDRRDLVRSKPKAEQADKANQTRARWFSCALSKRPLQEPIVACALGKLYNKDAIIEFLLDRSAYGDGADICGHVRSLKDIKTLKLTPNTAPASASPDSATDRAKFVCPLTLKEMTGHVPFVYLSTCGCVFSQAGLKTVSSSTPPNEKEPTLDKEEADVEAPKQQLDICPQCAAKYDKMQDVFIINPSSEEEERMRMAMERRRALDASKPKSKKRKHTSSKGDGAAPEPPSKKKPSTEGSSVSAHIAATSRAVASSLAMEEAKRKANMSDAVKSLYAPKDGIKRKETFMTMGTFTRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZE5</accession>
    <name>W4JZE5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_323282</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549202.1">
        <property type="nucleotide sequence ID" value="XM_009550907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZE5"/>
    <dbReference type="FunCoup" id="W4JZE5">
        <property type="interactions" value="174"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JZE5"/>
    <dbReference type="GeneID" id="20670953"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_323282"/>
    <dbReference type="eggNOG" id="KOG1484">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_7_0_1"/>
    <dbReference type="InParanoid" id="W4JZE5"/>
    <dbReference type="OrthoDB" id="78669at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="601"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="633"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="297"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="423"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="427"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="579"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW78917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="753" mass="83096" checksum="898A7F4B31FE765D" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZV5</accession>
    <name>W4JZV5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_453602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009551074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZV5"/>
    <dbReference type="STRING" id="747525.W4JZV5"/>
    <dbReference type="GeneID" id="20676399"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_453602"/>
    <dbReference type="HOGENOM" id="CLU_006410_1_0_1"/>
    <dbReference type="InParanoid" id="W4JZV5"/>
    <dbReference type="OrthoDB" id="2739948at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="421"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW79103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="541" mass="59855" checksum="06D480FA998F48B9" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4K084</accession>
    <name>W4K084_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_104433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549401.1">
        <property type="nucleotide sequence ID" value="XM_009551106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K084"/>
    <dbReference type="GeneID" id="20665999"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_104433"/>
    <dbReference type="HOGENOM" id="CLU_1065817_0_0_1"/>
    <dbReference type="InParanoid" id="W4K084"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="261" mass="28435" checksum="BDBBE39E9A2484A8" modified="2014-03-19" version="1">MTSAGPGTRGSRRRPETGGRGWRGLGVAKGSAGSRPVGVRAGVQPSLLSQSQPWPPLAPSFPVFTLQPVFTLPPFLRVPVPVDLHAHAHSYTYVDAPRARITDPFPLSIWAPRCCKTFTDPLALFFHSRFVSSLAPRVAPLHTHPLPFLSLLHHRPFVRPSIPLHLGAPPPPHVSAPPPPHPHAQNLPPQRHDSTARPTLVSFVWARSQNIRVSVHPVTRSAEPPHLLPTAQPLALAHAHAPYVPRRSHPHAPSHPDLVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4K098</accession>
    <name>W4K098_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_477786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548867.1">
        <property type="nucleotide sequence ID" value="XM_009550572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K098"/>
    <dbReference type="GeneID" id="20677779"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_477786"/>
    <dbReference type="HOGENOM" id="CLU_2320701_0_0_1"/>
    <dbReference type="InParanoid" id="W4K098"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="99" mass="10946" checksum="D1DA117FAB7C38C5" modified="2014-03-19" version="1">MQTTVGTITHQHKSRPADAAANDTRCLGISTSVRGGRPNPQMTEANVRNNTISPPKRPPLRRRTGTGVDTGLVPSGKDGYLWTRLGVDECTMTRKRYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0E4</accession>
    <name>W4K0E4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_386765</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548930.1">
        <property type="nucleotide sequence ID" value="XM_009550635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0E4"/>
    <dbReference type="GeneID" id="20672291"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_386765"/>
    <dbReference type="eggNOG" id="ENOG502QTB6">
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
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        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="325" mass="35462" checksum="912FBF8AF9846A3C" modified="2014-03-19" version="1">MFKRSSITGISLDASGLVALADLSTIAQRTALTGTASFLDILILAPGIHRHQAASEVNGRELPITGAMTTGYVFRIENQATVSYLQKIGRPGRLVNVLVKERATRPFGVQWFKVKFLTGGAAASVLYHLIVVLTVITMTLLLVIRDWWAVSVLLMLMFARIINVVVIKQRIVMGWKGAAEVGVQGDLLVLLSQDRWVRMLGLVDDLKAVTSGQWLRDETTIEGFATSFATLLVYVSAALASNASTIGSFFIVCLMLVSVALLGLCNSLTDCLQMFGRIVTTTGESKRYERRLDMAKELVESSQRDDWAIGLGLILPGDRAKKVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="3">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">HETIRDRAFT_156155</name>
    </gene>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="747525.W4K0L0"/>
    <dbReference type="GeneID" id="20667621"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_156155"/>
    <dbReference type="eggNOG" id="ENOG502RRJ9">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017006_1_0_1"/>
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    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42815">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42815:SF2">
        <property type="entry name" value="FAD-BINDING, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <dbReference type="EMBL" id="ETW79353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="606" mass="66875" checksum="A1E9A0E7C1BAC84F" modified="2014-03-19" version="1"> </sequence>
</entry>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <lineage>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
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                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="20666887"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_124920"/>
    <dbReference type="HOGENOM" id="CLU_2812683_0_0_1"/>
    <dbReference type="InParanoid" id="W4K0M6"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="67" mass="7320" checksum="4F3715555E9C2813" modified="2014-03-19" version="1">MSSEQTRKGGKLHYPAHTARIQLGIWDASSPQGTAEWAHGPIKWDDAPGKITAIVKSVSVECPTKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4K108</accession>
    <name>W4K108_HETIT</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
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                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_322919"/>
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    <dbReference type="InParanoid" id="W4K108"/>
    <dbReference type="OrthoDB" id="6511194at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="116" mass="13659" checksum="69EC14BF65AE71AD" modified="2014-03-19" version="1" fragment="single">WMVASIKTAENYKRSTHMTKQLHAWVRSFIINRDDLLFNLYSSWSVSMLKNRDLVNAIHEHLMGISKYVSAVAVVYFINSTEIKKQYSLQEKNILLAMAQRWMCMVGYHWQKSPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1A7</accession>
    <name>W4K1A7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_49340</name>
    </gene>
    <organism evidence="6 7">
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        <lineage>
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            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547942.1">
        <property type="nucleotide sequence ID" value="XM_009549647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1A7"/>
    <dbReference type="STRING" id="747525.W4K1A7"/>
    <dbReference type="GeneID" id="20678100"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_49340"/>
    <dbReference type="eggNOG" id="KOG3386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090404_0_1_1"/>
    <dbReference type="InParanoid" id="W4K1A7"/>
    <dbReference type="OrthoDB" id="73901at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF27">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN CTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW79597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="172" mass="18819" checksum="A0F1885CDBE8400F" modified="2014-03-19" version="1">MDMSMDGGMSLSMGNMIMYLHFTPGDNLWFLGWVASSPGAMVGACIGLFMLGMVDRWLGAMRAVMEMHWHARAQIALSNKLNSHALPTSREGGLQKGPSPLRNFVSHRAALPFIPAHDISRGIVHVTQTLLSFLFMLAVMTFQVGFILSIVVGLGVGETLFGRYSHHAAHLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1G2</accession>
    <name>W4K1G2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA repair protein rad9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_324423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549437.1">
        <property type="nucleotide sequence ID" value="XM_009551142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1G2"/>
    <dbReference type="FunCoup" id="W4K1G2">
        <property type="interactions" value="353"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K1G2"/>
    <dbReference type="GeneID" id="20671051"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_324423"/>
    <dbReference type="eggNOG" id="KOG2810">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035915_0_0_1"/>
    <dbReference type="InParanoid" id="W4K1G2"/>
    <dbReference type="OrthoDB" id="60092at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071479">
        <property type="term" value="P:cellular response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007268">
        <property type="entry name" value="Rad9/Ddc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04139">
        <property type="entry name" value="Rad9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="530" mass="58563" checksum="0668FBB95F9367B9" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1R3</accession>
    <name>W4K1R3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxysterol binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_410434</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548304.1">
        <property type="nucleotide sequence ID" value="XM_009550009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1R3"/>
    <dbReference type="FunCoup" id="W4K1R3">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K1R3"/>
    <dbReference type="GeneID" id="20672864"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_410434"/>
    <dbReference type="eggNOG" id="KOG2210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012334_0_0_1"/>
    <dbReference type="InParanoid" id="W4K1R3"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008142">
        <property type="term" value="F:oxysterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000010">
        <property type="entry name" value="Oxysterol-binding protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF184">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW79747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="42963" checksum="C2528EB27778699A" modified="2014-03-19" version="1">MADANNEQAGEAVPSAQRSSWTSFLKSIASFSGDLSSMTAPPFILSPVSLTEFPAYWCERPELFAAIADANTPEERSLAVLKWFISTLKGQYTSRNESMGSEKKPLNPVLGELFYGYWPDKNGRGETNLTVEQVSHHPPITAYFISNPSKGLELQGHNAQKTSFSGGSIIVKQIGHATLTIELGGGQKEEYIITLPRLRIDGLWYGSPYIELSENSYIQSSTGWLSTIEYKGKGYFSGKSHTFKAVVSPPGSNNAVHTLEGQWNATSKNIKTNATFTDVTGDKEEVSVRALDVQDEWESRKLWAKVAKGIREGDFETASREKTKIENEQRQRRRDEQAAGTTWQLKHFVHEDNDPLYERLGSFFRANPPTEDMYVFQHNVPSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4K212</accession>
    <name>W4K212_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_453806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549613.1">
        <property type="nucleotide sequence ID" value="XM_009551318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K212"/>
    <dbReference type="STRING" id="747525.W4K212"/>
    <dbReference type="GeneID" id="20676431"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_453806"/>
    <dbReference type="HOGENOM" id="CLU_1886027_0_0_1"/>
    <dbReference type="InParanoid" id="W4K212"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central" evidence="1">
        <location>
            <begin position="34"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="135" mass="14985" checksum="15C56CBB2833C2BC" modified="2014-03-19" version="1">MPLPDGANPMCPGWLSRLFFYGQQILMHMFLHLADDPKTQCFLDCFYKLCVTRCSSPSSASQIASCSQVSPSVAVANPNLPFHVYATLTRLPSIFALQHTLRSHFFMLTLNISTHVARLLCSRDKHLCLGASALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4K240</accession>
    <name>W4K240_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_435632</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549428.1">
        <property type="nucleotide sequence ID" value="XM_009551133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K240"/>
    <dbReference type="FunCoup" id="W4K240">
        <property type="interactions" value="384"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K240"/>
    <dbReference type="GeneID" id="20674835"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_435632"/>
    <dbReference type="eggNOG" id="KOG3327">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049131_3_1_1"/>
    <dbReference type="InParanoid" id="W4K240"/>
    <dbReference type="OrthoDB" id="425602at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01672">
        <property type="entry name" value="TMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000679">
        <property type="entry name" value="Thymidylate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="10">
        <location>
            <begin position="13"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW79171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="236" mass="27066" checksum="69FD51CA83EBED19" modified="2014-03-19" version="1">MEEVHERGAFIVIEGLDRSGKSTQVALLHEQLQAAGISTKIQRFPDRTTPIGKMIDSYLRSQSDLDDHAIHLLFSANRWELVTALKETLNAGTTVLCDRYAFSGIAFSASKDLPYDWCRAADISLPAPDLTLFLDISPEKAKERGRYGEERYENEEMQRSVRDVFRRMGEEMQQPANEQDQGKWITVDAGQDRDLVAKEIWNHRHDQGTKREGNKQCLRQKRVRDIADGETWCKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2A3</accession>
    <name>W4K2A3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_445554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548391.1">
        <property type="nucleotide sequence ID" value="XM_009550096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2A3"/>
    <dbReference type="GeneID" id="20675634"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_445554"/>
    <dbReference type="HOGENOM" id="CLU_1138115_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2A3"/>
    <dbReference type="OrthoDB" id="2747101at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="244" mass="27352" checksum="E018A6DD032EBFF7" modified="2014-03-19" version="1">MLDAHSYDSFPASFAEPEMEQYYHTHSSPSKLPQQMYNPPYSPSAFTFDPFAEDDDIQTSSSSDSHSPVPQSARTYGDRSYSQLQHSSRQQRGQQAGGEVQRHQKVEFLRQREWMRRVVAWVDHVNSGIADHHHYFYTPSPSALAPDTLYYSSKEPEPDLPLFDEEPYLIYSTPVPNSTSSQTSFGISGYIPPSPVSIPFSSPVPSISPSTIAPVKASPGRRVHSRVPSLDSIREEDEDVSAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2A4</accession>
    <name>W4K2A4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_324151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549473.1">
        <property type="nucleotide sequence ID" value="XM_009551178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2A4"/>
    <dbReference type="GeneID" id="20671026"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_324151"/>
    <dbReference type="HOGENOM" id="CLU_1865386_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2A4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="137" mass="15292" checksum="4E6034C460B6BD3A" modified="2014-03-19" version="1">MQLNYSTHLFPSLFHHPRQCLLSWFSLSVRVSFASSARTNLSAVIFGYLIYSHCVPCFCSFCQGRIPITLDTLASPSVRSLVRWSPSFLLGFAFSSLFCLASDAPLALRTHLGILEFYAPIMVLPVPCFPPTASWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4K311</accession>
    <name>W4K311_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">isocitrate dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="4">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_453158</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="4"/>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548716.1">
        <property type="nucleotide sequence ID" value="XM_009550421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K311"/>
    <dbReference type="FunCoup" id="W4K311">
        <property type="interactions" value="467"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K311"/>
    <dbReference type="GeneID" id="20676347"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_453158"/>
    <dbReference type="eggNOG" id="KOG1526">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023296_4_0_1"/>
    <dbReference type="InParanoid" id="W4K311"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="BTB" evidence="12">
        <location>
            <begin position="33"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW80208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="592" mass="65773" checksum="4D8C12E6E8A2B31B" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4L1</accession>
    <name>W4K4L1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_320094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4L1"/>
    <dbReference type="GeneID" id="20670643"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_320094"/>
    <dbReference type="HOGENOM" id="CLU_024199_2_0_1"/>
    <dbReference type="InParanoid" id="W4K4L1"/>
    <dbReference type="OrthoDB" id="3172239at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF5">
        <property type="entry name" value="F-BOX AND LEUCINE-RICH REPEAT PROTEIN 6"/>
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    </dbReference>
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        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="70"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="575" mass="64773" checksum="7D254023DEB7948C" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5Q6</accession>
    <name>W4K5Q6_HETIT</name>
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        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_410024</name>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547409.1">
        <property type="nucleotide sequence ID" value="XM_009549114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5Q6"/>
    <dbReference type="FunCoup" id="W4K5Q6">
        <property type="interactions" value="130"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K5Q6"/>
    <dbReference type="GeneID" id="20672826"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_410024"/>
    <dbReference type="eggNOG" id="KOG2322">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058671_0_0_1"/>
    <dbReference type="InParanoid" id="W4K5Q6"/>
    <dbReference type="OrthoDB" id="7933078at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd10429">
        <property type="entry name" value="GAAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF50">
        <property type="entry name" value="PROTEIN LIFEGUARD 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW80690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="281" mass="30880" checksum="425EDB03201A6511" modified="2014-03-19" version="1">MSQYPVPPPSYGATVPSPKSPTAGDSLREPLLGSPRFEAGSSSGGIYNQPSPGELPDDFKYGVTVSESSPEIRNAFVRKVYTILFSQILATTIVGGVISQSQSTVFWVQTHAWSFYVPLFGTLVVLGLLYWKRHNHPLNIGLLSLFTVLEAFTLGVVTAFYDNVIVMQALLITTGVFLGLTLFTLQSKYDFSGLGPWLFGGLIALLMTGLVGVFLPFSRTMDLVFAIGGTLLFSGYVVYDTYIINSRLSPDEYIMGAISLYLDFINLFLNILRLLNNVQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5Y5</accession>
    <name>W4K5Y5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_452599</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547884.1">
        <property type="nucleotide sequence ID" value="XM_009549589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5Y5"/>
    <dbReference type="GeneID" id="20676274"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_452599"/>
    <dbReference type="HOGENOM" id="CLU_2722537_0_0_1"/>
    <dbReference type="InParanoid" id="W4K5Y5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="72" mass="7699" checksum="296D3D4BFDCD8C9F" modified="2014-03-19" version="1">MMSVPQRRASDAEGVRTRAKAPALGRPSLLGTSDHTTSGRNAAQPQQLVPCGSQERGATRYKYAAGASQWKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6F4</accession>
    <name>W4K6F4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4246 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_51381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_51381"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="415532at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049192">
        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="2">
        <location>
            <begin position="51"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4246" evidence="2">
        <location>
            <begin position="251"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW81407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="481" mass="55099" checksum="595760DB78DFDB47" modified="2014-03-19" version="1" fragment="single">SELRMSRLSWAIRSKIDWQTKMQNTEILERWRQEALEQQQGLPTEEKLTSNMINYVLSELEGYAKLSDPATGIQHACNESVFSSSRLVPKNLNDALRAEVAKLEDIPEDERDWHPGSNEQVLDLVHPSLHCVVYGRTLAIDASIPNQLKPLPAPKRRKKEKMFLSRRLAWLPSDFAVDHDSAVRLTSPYINNIHPSKKELYATLESILAAFIPMFERVLGSIDRMERPRIDGSFPRRRRNTNDSKPPVNLRGKTLQVIVKLANIHLTPEKPEYGGGSWHVEGMLNERIVSTGIYYYDSENISESHLAFRVSTTAPKYHTQDDFVCMEFLYGMKLNEGLVQERGSVHTSDGLALAFPNIYQHQVQPFRLLDPTKPGHRKILAFFLVDPNVRINSATNVPPQQKQWYREALDVPEAASGSGQVPRASAFTVEVKNMIVEHVDGLMTREEAEQYREELMQERRGFVNTYNTDVMEVRTFSMCEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6T4</accession>
    <name>W4K6T4_HETIT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_50891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
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            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6T4"/>
    <dbReference type="GeneID" id="20678162"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_50891"/>
    <dbReference type="eggNOG" id="ENOG502S3G3">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_32_0_1"/>
    <dbReference type="InParanoid" id="W4K6T4"/>
    <dbReference type="OrthoDB" id="128646at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="126" mass="14547" checksum="8C9E608E13A5B542" modified="2014-03-19" version="1" fragment="single">MNDRIITPIRLNVKVSNRSQNAGAKATIDSACEGVIVNETWVKRHHFPTYTLNNPIRVRNVDDTINKAGLIRSALDVNLTIRDIRGRTHTERVQMFISNLGKDDLILGTDWLKYHDPSIEWRRREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7H4</accession>
    <name>W4K7H4_HETIT</name>
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        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_444905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009548068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7H4"/>
    <dbReference type="STRING" id="747525.W4K7H4"/>
    <dbReference type="GeneID" id="20675600"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_444905"/>
    <dbReference type="eggNOG" id="KOG1164">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019279_2_7_1"/>
    <dbReference type="InParanoid" id="W4K7H4"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW81753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="539" mass="60351" checksum="A9AAC9746FE64C70" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8P4</accession>
    <name>W4K8P4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_168891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546713.1">
        <property type="nucleotide sequence ID" value="XM_009548418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8P4"/>
    <dbReference type="GeneID" id="20668190"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_168891"/>
    <dbReference type="HOGENOM" id="CLU_2527730_0_0_1"/>
    <dbReference type="InParanoid" id="W4K8P4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="84" mass="9580" checksum="DAF502A31716345D" modified="2014-03-19" version="1">MAARGYCKISEKRLMSLRIKRAFSGRARRVRGNGPEVRATSVCIQFNRRAMRLVPSTRAWVWGGRKTKDRLCNIRSIIGAELTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8Q3</accession>
    <name>W4K8Q3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_317790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546087.1">
        <property type="nucleotide sequence ID" value="XM_009547792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8Q3"/>
    <dbReference type="STRING" id="747525.W4K8Q3"/>
    <dbReference type="GeneID" id="20670445"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_317790"/>
    <dbReference type="eggNOG" id="ENOG502SVH8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018408_0_0_1"/>
    <dbReference type="InParanoid" id="W4K8Q3"/>
    <dbReference type="OrthoDB" id="5569250at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="364"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW81441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="844" mass="94342" checksum="AA4EF62DF5C859D1" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4K920</accession>
    <name>W4K920_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_141600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546790.1">
        <property type="nucleotide sequence ID" value="XM_009548495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K920"/>
    <dbReference type="GeneID" id="20667011"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_141600"/>
    <dbReference type="HOGENOM" id="CLU_2574162_0_0_1"/>
    <dbReference type="InParanoid" id="W4K920"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="81" mass="9027" checksum="186BDA73C86A50DC" modified="2014-03-19" version="1">MAYAGGYGVRENRRAEQGSTCHFILKTCTCICAPAMRCGWDVESALRIWSCPSQGLYEHVLQIALPEVRTRADPPNLVQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9C7</accession>
    <name>W4K9C7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_315939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544748.1">
        <property type="nucleotide sequence ID" value="XM_009546453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9C7"/>
    <dbReference type="GeneID" id="20670273"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_315939"/>
    <dbReference type="HOGENOM" id="CLU_976794_0_0_1"/>
    <dbReference type="InParanoid" id="W4K9C7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="285" mass="32641" checksum="45C00B41F5C8C983" modified="2014-03-19" version="1">MFRKRKYNPLLLLPTASALQAIVDILDQFPNALKEISRWIEPDIDSGLASKYFKDFTLAANAQFIRQHAHWHGEVDLARFWMDLFVHCALVLIQLELSMMMLGKIEHPRTVPLSTLLSIVNEGPVAFNVFLQPIWMEQESPAQTATTVTEMLHQMLLQSENSHQWGEYLRYPMLRVIQYLAWAQDRLALASIHRRVVMGITQWAVRKATILHLVKEVLGVFQTGRDLVHRAVVAARGPFENVGAPYDKFDMEMWDEKIVQEIVASHASPTDVLCLRPDHCQTCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9G1</accession>
    <name>W4K9G1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chorismate mutase</fullName>
            <ecNumber evidence="3">5.4.99.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_318397</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13898"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="5.4.99.5" evidence="3"/>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546330.1">
        <property type="nucleotide sequence ID" value="XM_009548035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9G1"/>
    <dbReference type="FunCoup" id="W4K9G1">
        <property type="interactions" value="309"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K9G1"/>
    <dbReference type="GeneID" id="20670508"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_318397"/>
    <dbReference type="eggNOG" id="KOG0795">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057757_0_1_1"/>
    <dbReference type="InParanoid" id="W4K9G1"/>
    <dbReference type="OrthoDB" id="191918at2759"/>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.590.10">
        <property type="entry name" value="Chorismate mutase, AroQ class superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008238">
        <property type="entry name" value="Chorismate_mutase_AroQ_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037039">
        <property type="entry name" value="CM_AroQ_sf_eucaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01802">
        <property type="entry name" value="CM_pl-yst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145:SF12">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="Chorismate mutase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51169">
        <property type="entry name" value="CHORISMATE_MUT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="13">
        <location>
            <begin position="156"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW81716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="292" mass="32558" checksum="C4D89026149F275F" modified="2014-03-19" version="1">MLAEDPLSLDRIRSILTRLEDTIIFSLIERAQFAHNPKIYQPGAFNHVPQLGTHSWLLWFLHETECFHAKARRYTGPDEYPFTSNLPAPVLPPLKYPAILHPNTVDANPAILAFYTRHIVPRITRPATRALAAAKRARAIDPATDPDPDDDGNHGSAATIDVEVLQAISKRVHYGKFVSESKFSSHPAAFIPAIRARDRTALAALITKPDVERRLLVRLRNKASLYAQDFASDGAPRPLDPAGGAHGKIDVDGVVELYESYIIPLTKEVEVDYLLQRLDGLSPEEIQKLSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAH4</accession>
    <name>W4KAH4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_416564</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544721.1">
        <property type="nucleotide sequence ID" value="XM_009546426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAH4"/>
    <dbReference type="GeneID" id="20673333"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_416564"/>
    <dbReference type="HOGENOM" id="CLU_2705093_0_0_1"/>
    <dbReference type="InParanoid" id="W4KAH4"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW82355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="73" mass="8102" checksum="6D1570C55BA74295" modified="2014-03-19" version="1">MSASEDVRLPESEILAQMSTLIIAAMDTTSAALSRILYLLSQNTDVQDKLRAELTRAREESRGPIGEMDYSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAH5</accession>
    <name>W4KAH5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_384480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546656.1">
        <property type="nucleotide sequence ID" value="XM_009548361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAH5"/>
    <dbReference type="GeneID" id="20672206"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_384480"/>
    <dbReference type="eggNOG" id="ENOG502SENF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024697_0_0_1"/>
    <dbReference type="InParanoid" id="W4KAH5"/>
    <dbReference type="OrthoDB" id="3367070at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="529"/>
        </location>
    </feature>
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        <property type="entry name" value="Repressor of RNA polymerase III transcription Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504:SF0">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037240">
        <property type="entry name" value="RNA_polIII_Trep_MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW83243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="356" mass="39552" checksum="9C53AC0FA48CFEB0" modified="2014-03-19" version="1">MKYIEIPELSRLAQALSHEGPECSVHTRIEAYSCKNIKRDKKLFKSLEHAYNDEVSNSPPVPSFIALDREAEMTPFGPIDKHASRKTLYLLIATLNIAFPDHEFSDVKPAHFNKEESGAGVLNALSTTLVAPHHAGMRAPRTYSAYPPTSSEFFPSSLPTSSSPPQFLPSPFAPPQIVTGTHPSLYRILDDVIGLPECEVFSYVPDIESDPHANDYSDDEDDIASVGDSDTSSDEPEETFAFDDYDVDEAARHRPAHGLGDRARISSDDDVLGHVHGRRHGALLWSSHWFFLNRKLKRILFVSVWARTRGLMHYRDEMEEEYGNVEKVATIGGERFLGWEGAIGLGARAMGLSASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KD61</accession>
    <name>W4KD61_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_240155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545310.1">
        <property type="nucleotide sequence ID" value="XM_009547015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KD61"/>
    <dbReference type="GeneID" id="20668845"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_240155"/>
    <dbReference type="eggNOG" id="ENOG502SMUN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058263_1_0_1"/>
    <dbReference type="InParanoid" id="W4KD61"/>
    <dbReference type="OrthoDB" id="3223825at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="245" mass="27630" checksum="30D0EF2B0B363562" modified="2014-03-19" version="1" fragment="single">MDSFSRAGNSALDDLFLERLDVFIDKTLSDMKTFAEREGCSLDIVRRHVAQWHSQYLFSAASPSPPEDRRQRVNLILVSTSQTLEALHQTAGLHSFFLAVDPTDPTDNGFLGGTVLGREFWRGLRNGGVNGAKAFKMQAMSSHSPTLESFHDHHQAPSTSMDKRTPAQRLKSEVYAGIRTALRMASGIRNAEMRWTNHDLLQTYGVRIDGWPKDIPKRNPSSLTVAENKRLKECLRNESLIFHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDX4</accession>
    <name>W4KDX4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_170529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543770.1">
        <property type="nucleotide sequence ID" value="XM_009545475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDX4"/>
    <dbReference type="GeneID" id="20668292"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_170529"/>
    <dbReference type="HOGENOM" id="CLU_2250491_0_0_1"/>
    <dbReference type="InParanoid" id="W4KDX4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="104" mass="11939" checksum="A1E3E74A12581D0D" modified="2014-03-19" version="1">MLKVALLEDLFLGDLFSGQSRRTDFTDTEAQLKGPSYSSRGLKDSIAYRGTSPSRRREQTLSLKFPRRRRLSFYDVPGRRGDCLGIKHKKNPRSTDDIVTDLHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEB0</accession>
    <name>W4KEB0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Potassium:hydrogen antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_150936</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BUD31 (G10) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543793.1">
        <property type="nucleotide sequence ID" value="XM_009545498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEB0"/>
    <dbReference type="FunCoup" id="W4KEB0">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KEB0"/>
    <dbReference type="GeneID" id="20667375"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_150936"/>
    <dbReference type="eggNOG" id="KOG1650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_10_1_1"/>
    <dbReference type="InParanoid" id="W4KEB0"/>
    <dbReference type="OrthoDB" id="2687058at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001748">
        <property type="entry name" value="BUD31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050794">
        <property type="entry name" value="CPA2_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468">
        <property type="entry name" value="CATION/H + ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468:SF0">
        <property type="entry name" value="K(+)_H(+) ANTIPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01125">
        <property type="entry name" value="BUD31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00322">
        <property type="entry name" value="G10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="350"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
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        <location>
            <begin position="177"/>
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        </location>
    </feature>
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        <location>
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        </location>
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        <location>
            <begin position="16"/>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW84079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="977" mass="105600" checksum="78EFADA6DAD5E6B8" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4KF14</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">HETIRDRAFT_408514</name>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTI2 family.</text>
    </comment>
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    </dbReference>
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        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="241" mass="27153" checksum="8DB7628B515B46A9" modified="2014-03-19" version="1" fragment="single">MAILEESPESTPSDQQSLLQTLRIPAEYARFEALGDNEIYDRLDQWKTNALSALSTLREQLKLNSHLGTEQQADIAFHAASYMGEVGEWSTEQMHDISVDTLELLGEPDIHVLERTLNHHIKSLFRANPHPSLNASTGRKISRQAGGPMAAQDIYEDQLWKRSPGVGNALSWCVQHIHTEMYERLWGLVVPPIMILLDDYEVKYKIEGIHIVEALLGNAPPDLLKRTGISDLLFSVLHRAL</sequence>
</entry>
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    <name>W4KFW3_HETIT</name>
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        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_314679</name>
    </gene>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543896.1">
        <property type="nucleotide sequence ID" value="XM_009545601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFW3"/>
    <dbReference type="FunCoup" id="W4KFW3">
        <property type="interactions" value="422"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KFW3"/>
    <dbReference type="GeneID" id="20670147"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_314679"/>
    <dbReference type="eggNOG" id="KOG3406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110343_1_1_1"/>
    <dbReference type="InParanoid" id="W4KFW3"/>
    <dbReference type="OrthoDB" id="10249311at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000530">
        <property type="entry name" value="Ribosomal_eS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047860">
        <property type="entry name" value="Ribosomal_eS12_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00972">
        <property type="entry name" value="RIBSOMALS12E"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01189">
        <property type="entry name" value="RIBOSOMAL_S12E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="32"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW84200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="147" mass="16075" checksum="13694F76BA754EC2" modified="2014-03-19" version="1">MSDAGDEIKVEPEVEAEAEVSEAPKGKLSVEDALQQVLKTSLVHDGLARGLRECAKALDRRQAHLCVLVETCTEAEYIKLIEALCATHKIPLIKVGDAKVLGTWAGLCKIDREGNPRKVVGCSCVVVKEYGAETEGRHVLEDYFKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KG85</accession>
    <name>W4KG85_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_247730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544495.1">
        <property type="nucleotide sequence ID" value="XM_009546200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KG85"/>
    <dbReference type="STRING" id="747525.W4KG85"/>
    <dbReference type="GeneID" id="20669199"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_247730"/>
    <dbReference type="eggNOG" id="ENOG502S8C1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2596646_0_0_1"/>
    <dbReference type="InParanoid" id="W4KG85"/>
    <dbReference type="OrthoDB" id="3361196at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW84868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="100" mass="10432" checksum="88334F5CF53E71E6" modified="2014-03-19" version="1" fragment="single">NYDSISSCAEAAPVLANVSMIIFNPGAFIDVIKCACTDTFQSVFPQCADCFERTNQTDVLDTPDLPSVVSGMRQVCSLASALLGNVSETDGEVSSSSSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KG95</accession>
    <name>W4KG95_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_311941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544504.1">
        <property type="nucleotide sequence ID" value="XM_009546209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KG95"/>
    <dbReference type="GeneID" id="20669912"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_311941"/>
    <dbReference type="HOGENOM" id="CLU_066263_0_0_1"/>
    <dbReference type="InParanoid" id="W4KG95"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="302" mass="33372" checksum="738660FFCA8FFCCC" modified="2014-03-19" version="1">MTYPYYAAYNTCGWEDGLSLLSQEQTTAAHMDASGPPAVYPSGYPTQQINALWYEPVLPTIEPEWAPHYPQLGYAMAGPPHVAHDDFYFPQQTLLAEESNHQVATIAYSTAYYHERLASPLYLPCNVVQPQYGAVHMSGGPVAGPSTTRATIGERIGARYTPYQQRPRLEVAVVGPGGIHEAPEGATLHQTTSISRKSARRNDTTNGLIPEAVQASGEGRTHPEVTRRAPRMDMRQTPYLSSDWNCHKCKGGFGRVHELKRHLNTAKAHVAASLTCDECKDSATFSRPDVLFAHKRTFHGWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGJ9</accession>
    <name>W4KGJ9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_438128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW84988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541885.1">
        <property type="nucleotide sequence ID" value="XM_009543590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGJ9"/>
    <dbReference type="GeneID" id="20675014"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_438128"/>
    <dbReference type="HOGENOM" id="CLU_106806_0_0_1"/>
    <dbReference type="InParanoid" id="W4KGJ9"/>
    <dbReference type="OrthoDB" id="10609901at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW84988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="196" mass="21905" checksum="24366350B28378A0" modified="2014-03-19" version="1">MRQALVLSHADKHLITSLANVLLMMYGRSSRLEHLQEAKQLAEEMRQREAGLDCAVLSTMETHLNETGSSLPDIDTWLKLHCRITTLTPTTHVDCPERLMTFETAMRERGSSARDRIEALKEAERLTSLGFGVSSRLKVLNELVRQCRTIGTEDASQEALPSSRVKNYHTHSTTLMISPEPLVSTPQPSPSMLPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHC8</accession>
    <name>W4KHC8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ras-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_313540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544128.1">
        <property type="nucleotide sequence ID" value="XM_009545833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHC8"/>
    <dbReference type="STRING" id="747525.W4KHC8"/>
    <dbReference type="GeneID" id="20670041"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_313540"/>
    <dbReference type="eggNOG" id="KOG0087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045021_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHC8"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000808">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW84456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="37241" checksum="35239AB07338AB14" modified="2014-03-19" version="1">MAAYPRMDPYKRSRYEQGIDAKIVVMGNTGVGKTSLLQRYTQNKFDPRNTTSTTGAFFVTKKVYVDGMKVRLQLWDTAGQERFRSMAPMYYRGANAALLLYDITSAVSFEDVRGWLEELKKNCSTDLIIYIVGSKADLQHYKQVSSDLARLSLHRWFPPPRPPTPPPPPQPSTFSYIRPRFTSFTSIPRSTGALALNRAKSTNGALQTSRFGSHNGSRAWADAGDQDTNSLIEDYYEDEDDDREWGLEPGMELFEVSAKDDLGIQQLFDSLIGAIIQKKDSIEQENEMKRRDSVFLTPAVNPPTWTTQAEEEEAREKAASRSGAWSCCQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHQ4</accession>
    <name>W4KHQ4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_457310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542247.1">
        <property type="nucleotide sequence ID" value="XM_009543952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHQ4"/>
    <dbReference type="GeneID" id="20676815"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_457310"/>
    <dbReference type="eggNOG" id="ENOG502R4JR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041041_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHQ4"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF54">
        <property type="entry name" value="FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="3">
        <location>
            <begin position="99"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW85383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="402" mass="44728" checksum="F1C5737122A4C779" modified="2014-03-19" version="1">MSTTSTITEAAPRQPDIDYHPDHVKYLARTARRLQSDPSLPKSPLPAGFPTQVEGPIVWEGADWKEEKQWVYELSQVELKEIDDAIKHFQGFGKPLGYLSQGTFPLPTLSTLLHNFSKELYFGRGFFVLRTLPVDKYSREEIAIMYAGIASHVGSARGKQDGLGSVLAHIKDLTLTHGNGAAGKDGKPFGNAAYTTDAQVFHTDVGDLIALLALQTAKEGGTSRIASGARVYNELAKTRPDLLQVLSDPWPLDSFGGDPAYTTRPLLYYSEPHVIIQYSRRHFTGYGIQKRSPNIPVISEAQAEALDAVHYLAEKFSLGLNFQKGDIQFINSLGLLHARDAFVDDPEHTRHLIRLWLRNDELAWKTPGPLEPIWKRLYSVGSDQQRFPLEPEIRTKAGGVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4KI47</accession>
    <name>W4KI47_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_443514</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SHQ1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542369.1">
        <property type="nucleotide sequence ID" value="XM_009544074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KI47"/>
    <dbReference type="FunCoup" id="W4KI47">
        <property type="interactions" value="616"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KI47"/>
    <dbReference type="GeneID" id="20675528"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_443514"/>
    <dbReference type="eggNOG" id="KOG3247">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030217_1_0_1"/>
    <dbReference type="InParanoid" id="W4KI47"/>
    <dbReference type="OrthoDB" id="73639at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00298">
        <property type="entry name" value="ACD_sHsps_p23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039742">
        <property type="entry name" value="Shq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048696">
        <property type="entry name" value="SHQ1-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007009">
        <property type="entry name" value="Shq1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967:SF0">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04925">
        <property type="entry name" value="SHQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21413">
        <property type="entry name" value="SHQ1-like_CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="485"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="519"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW85517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="544" mass="59642" checksum="0D3FE2499CC462EC" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIC7</accession>
    <name>W4KIC7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_310608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542453.1">
        <property type="nucleotide sequence ID" value="XM_009544158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIC7"/>
    <dbReference type="GeneID" id="20669790"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_310608"/>
    <dbReference type="HOGENOM" id="CLU_2432846_0_0_1"/>
    <dbReference type="InParanoid" id="W4KIC7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="91" mass="10075" checksum="5945C51172AFF942" modified="2014-03-19" version="1" fragment="single">IRVVLAKSSGAYCGLCRVQWHRALSGDHNPLLIVDSPATKSFIAILLPLCLLVRSFWPSNMSSILSVLKTKLREYMLALPNSAAEDKDYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIQ9</accession>
    <name>W4KIQ9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_244280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542438.1">
        <property type="nucleotide sequence ID" value="XM_009544143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIQ9"/>
    <dbReference type="GeneID" id="20669038"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_244280"/>
    <dbReference type="HOGENOM" id="CLU_179474_1_0_1"/>
    <dbReference type="InParanoid" id="W4KIQ9"/>
    <dbReference type="OrthoDB" id="2941157at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="72" mass="8095" checksum="56EF2C2C9D28FE11" modified="2014-03-19" version="1" fragment="single">QKYKPVALEVRLVLADLPDKFRIVCNIRGDPLAGLPTLTPNPPPFAPTGQYISKRRDLINQVHSSDFLWPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJ24</accession>
    <name>W4KJ24_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Copper chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_167942</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ATX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542664.1">
        <property type="nucleotide sequence ID" value="XM_009544369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJ24"/>
    <dbReference type="FunCoup" id="W4KJ24">
        <property type="interactions" value="342"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KJ24"/>
    <dbReference type="GeneID" id="20668140"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_167942"/>
    <dbReference type="eggNOG" id="KOG1603">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134973_3_1_1"/>
    <dbReference type="InParanoid" id="W4KJ24"/>
    <dbReference type="OrthoDB" id="689350at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000008">
        <property type="entry name" value="Copper transport protein ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051881">
        <property type="entry name" value="Copper_transport_ATOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365:SF1">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="3"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW85848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="72" mass="7944" checksum="447FA499B4C1F234" modified="2014-03-19" version="1">MSEHSYRFDVKMTCGGCSGAVERVLKKAEGVSSYDVSLEKQEVLVKGTIGYDDLLEKIKKTGKEVRSGETLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJD2</accession>
    <name>W4KJD2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small COPII coat GTPase SAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Small COPII coat GTPase sar1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">HETIRDRAFT_471210</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542759.1">
        <property type="nucleotide sequence ID" value="XM_009544464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJD2"/>
    <dbReference type="FunCoup" id="W4KJD2">
        <property type="interactions" value="508"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KJD2"/>
    <dbReference type="GeneID" id="20677384"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_471210"/>
    <dbReference type="eggNOG" id="KOG0077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_6_0_1"/>
    <dbReference type="InParanoid" id="W4KJD2"/>
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    <sequence length="189" mass="21498" checksum="B526C0EF6260F7EB" modified="2014-03-19" version="1">MFIINWFWDVLAQLGLLHKNAKILFLGLDNAGKTTLLHMLKNDRLATLQPTLHPTSEELAIGNVKFTTYDLGGHQQARRLWRDYFPEVDGIVFLVDSADFERFPESKAELDALLSIEELSKVPFLILGNKIDAPGAVSEEELRHHLGLYQTTGKGKVPLNDIRPIEIFMCSVVQRQGYGEGFRWVSQYI</sequence>
</entry>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">TC 32-1</strain>
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    <sequence length="322" mass="37720" checksum="F82D32E9CBB37C90" modified="2014-03-19" version="1">MSTNKAEGRREDALAKQRNQAREEYERQKQQLINETEKARPSNARFIGQNDSMEDSLKKSTVGLVRLEDFQQRRKELEEAKAREAARTDDLKEDQKKVKKRKKAAKATLSFALDDEGGEEEGSGSSTPNLELNGEKPAKRAKFRKNPNVDTSFLPDREREEAERREREELRQEWIRRQEEMKQEEIEVTYSYWDGSGHRKSVICKKGDDIGTFLEKCRQQFPELRSVSVDNLMYIKEDLIIPQHHTFYDFIINKARGKSGPLFNFDVHDDVRLLADATKEKDESHAGKVVERSWYQRNKHIFPASRWEVFDPEKTYGKYTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJM1</accession>
    <name>W4KJM1_HETIT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">HETIRDRAFT_100534</name>
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    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="747525"/>
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            <taxon>Dikarya</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542702.1">
        <property type="nucleotide sequence ID" value="XM_009544407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJM1"/>
    <dbReference type="GeneID" id="20665693"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_100534"/>
    <dbReference type="HOGENOM" id="CLU_1503628_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJM1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="179" mass="19005" checksum="F7E9B24EA5B6D086" modified="2014-03-19" version="1">MRWRSLAVASGREKTEKGEAREGRVCGGGDGLGGRVGGKRKEIGGKRGIWSRLLRRLTASRGEERPGSGQASGEEATAFSAVTHPSRTAFASLQLPLPAMGPSSSSPHPTPLPLTPAARTSSPDTCLISSGTLVYYVCPSRGAEARSPYHDLPPLTKARPPWDPCPIRTAARRLSYDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJV4</accession>
    <name>W4KJV4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUMO-conjugating enzyme UBC9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin-conjugating enzyme E2-18 kDa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_414959</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542778.1">
        <property type="nucleotide sequence ID" value="XM_009544483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJV4"/>
    <dbReference type="FunCoup" id="W4KJV4">
        <property type="interactions" value="1025"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KJV4"/>
    <dbReference type="GeneID" id="20673210"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_414959"/>
    <dbReference type="eggNOG" id="KOG0424">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_12_0_1"/>
    <dbReference type="InParanoid" id="W4KJV4"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000035">
        <property type="entry name" value="SUMO-conjugating enzyme ubc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="13">
        <location>
            <begin position="4"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW85984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="158" mass="18071" checksum="7CAA887B6F45B2E9" modified="2014-03-19" version="1">MSGICRPRLTEERKQWRKDHPFGFYAKPTKAPDGSMNLMEWEVGIPGKEGTPWEGGLYKLMMIFPEDYPTKPPKCKFSPPLFHPNVYPSGTVCLSILDEEKSWKAAITIKQIVLGIQALLNDPNVNDPAQSDAYTMFKNDKAAYERRVRQQARENIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4KK12</accession>
    <name>W4KK12_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_424692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542240.1">
        <property type="nucleotide sequence ID" value="XM_009543945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KK12"/>
    <dbReference type="GeneID" id="20674000"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_424692"/>
    <dbReference type="HOGENOM" id="CLU_1094411_0_0_1"/>
    <dbReference type="InParanoid" id="W4KK12"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="254" mass="27863" checksum="999A876F45F5668B" modified="2014-03-19" version="1">MVSSLGQYVLDVGQVLPPAENSNGLPRSTRWNAVVHQRSSAAMLSSGMIGVSSTASVTRQLLQASFNCTFEGQHTVVHEYHAFSNYGTARPSDDIEASSPTDIEVDRVLLLEDMSDPRSISRERFYDVARALERRGHSGAPVPACFKQEWPRSVDDQGCRDHRHRLSVSGATLTRYDNAGSGIARAVKYGRLGIVRAVRTEEWTMWEGKAKADIGVALSLEATGSSQNGNHTRSQTPVRWLPHCVKQSVKKLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4KK97</accession>
    <name>W4KK97_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Monopolin complex subunit Csm1/Pcs1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_380402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542905.1">
        <property type="nucleotide sequence ID" value="XM_009544610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KK97"/>
    <dbReference type="GeneID" id="20672020"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_380402"/>
    <dbReference type="eggNOG" id="ENOG502SC4G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042819_0_0_1"/>
    <dbReference type="InParanoid" id="W4KK97"/>
    <dbReference type="OrthoDB" id="3216420at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033551">
        <property type="term" value="C:monopolin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990644">
        <property type="term" value="F:microtubule site clamp"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045144">
        <property type="term" value="P:meiotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23787">
        <property type="entry name" value="RWD_CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040349">
        <property type="entry name" value="Csm1/Pcs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038608">
        <property type="entry name" value="Csm1/Pcs1_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006:SF1">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="43842" checksum="4019D1650D0138E3" modified="2014-03-19" version="1">MTKNKAKRTEPPTVNGKATTRVNGKPKADPPHKLSKKVSKTIPMEVKEDFEMIEGSEDEIPITQKVVASRKARQTSTTVPLAPRVKENAVSTREFERITKQLEEVISQRDQLTNQLEELFSIRQTEQEEALEASNVVYETKIKAQEDLIQELTSQIARIDPLVNTGQTSTLHFLTREAAEEEQRAIKAKIADLKSVIKEKDQIIKSKDIDIENVRQQLKDAQKELDAEVERSKAIASKARGPAATATTSAKSVSVHDPHHSATIQLYEDVTNLLITGAKIAEGPMPKTDSVTFRCVYSGGSPTKSLNFSLHTYWTPKHDAQEPYALTDFDEQVQFTPLELDKESPDFVESLDFLKDTFTFSRNQMDVFLKTLWDNVGGPGADNDDDVEMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKJ0</accession>
    <name>W4KKJ0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_415287</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543103.1">
        <property type="nucleotide sequence ID" value="XM_009544808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKJ0"/>
    <dbReference type="STRING" id="747525.W4KKJ0"/>
    <dbReference type="GeneID" id="20673236"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_415287"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="InParanoid" id="W4KKJ0"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW86358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="337" mass="37654" checksum="CC36A32C87A709FE" modified="2014-03-19" version="1">MSSPISDLPDFTGEIIDNGSLHFLRCLGSGGSGVVYLAVDANAAGTPKEYAVKCMLKLDPLDDQTFAQIREIALHIAVSDHPNIISIHRIVYDERYLFIVMDLCEAGDLYDAILIRKVYRNNDELVKLAFTKLIDAVAACHNDGIYHRDIKPENILCSQDGSELWLADFGIATTNIIIPINNGGTTYYMSPECHRNEYSRRGLSPEHCDIWALGIILLNFLTSSNPWLVAHPSDGDFNNFFKEPDYLRTLFPTISIQANALLRRILVMNPYERISLDELRKEVALIGTFFTTDRLPVTSNSCSTACSSIEAITPEPFTTQADVDIEELQKALLNLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKW1</accession>
    <name>W4KKW1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_122088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543072.1">
        <property type="nucleotide sequence ID" value="XM_009544777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKW1"/>
    <dbReference type="STRING" id="747525.W4KKW1"/>
    <dbReference type="GeneID" id="20666769"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_122088"/>
    <dbReference type="eggNOG" id="KOG0098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_23_1_1"/>
    <dbReference type="InParanoid" id="W4KKW1"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW86324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="235" mass="25753" checksum="5CF8B3ED70618B73" modified="2014-03-19" version="1">MADISWHYVLKFIITGDAAVGKSSLLIRLTDQRFLTNPDPTLGVEFGSKLITIPEEDKVIKLQCWDTAGTESFRSITRSYYRGAAGCLLVYDVTSRQSFLNARTWLADVRAHADPHLTCILVGNKIDLCPPEPEPEPAPESMPESESSDTTAPRPLETSASAPPHSTHDAFGPVPARRRQVPAAEAAAWAREEGLLFVEASAKSGSGVDRAFEDACRDILDKIRRGVFDDERVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLV8</accession>
    <name>W4KLV8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_247316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543095.1">
        <property type="nucleotide sequence ID" value="XM_009544800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLV8"/>
    <dbReference type="GeneID" id="20669164"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_247316"/>
    <dbReference type="HOGENOM" id="CLU_1829999_0_0_1"/>
    <dbReference type="InParanoid" id="W4KLV8"/>
    <dbReference type="OrthoDB" id="3058546at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="14478" checksum="5B14883F55DE231F" modified="2014-03-19" version="1" fragment="single">LVGTFLVGIGDSTRREHLEVGDVALAACAGEWTAFYPDVPHCVTTIARGHRAVLAFKVYRSDDADASAEVPGDPEIARRVQGILDKIPSPFGLLLPHKYCMGTERLSGFDALLYTCLQKRADARVDLLPIVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMJ8</accession>
    <name>W4KMJ8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ceramide glucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.80</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glucosylceramide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">UDP-glucose ceramide glucosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">UDP-glucose:N-acylsphingosine D-glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HETIRDRAFT_30717</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">TC 32-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.80" evidence="5"/>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540282.1">
        <property type="nucleotide sequence ID" value="XM_009541987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMJ8"/>
    <dbReference type="STRING" id="747525.W4KMJ8"/>
    <dbReference type="GeneID" id="20669465"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_30717"/>
    <dbReference type="eggNOG" id="KOG2547">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030898_1_0_1"/>
    <dbReference type="InParanoid" id="W4KMJ8"/>
    <dbReference type="OrthoDB" id="1483400at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008120">
        <property type="term" value="F:ceramide glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006679">
        <property type="term" value="P:glucosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02520">
        <property type="entry name" value="Glucosylceramide_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726:SF0">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETW86924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="460" mass="51536" checksum="3A548DC92E7EAD90" modified="2014-03-19" version="1">MNSPEDVPSAIFERSALPLGIAVAGLVWYGAIWSVGLLGCWSARKRYRIRPRSPLSSSSAQTAPGVSILRPIKGLDTNLYENLESSFVQEYPNFELLLSVADEDDQALPVIRELVAKYPGTNARVIVGEEIVGVNPKVNNLIRSYREAAHDILWVLDSNVTVAPGTLARAVDILNRPPPPIPGPRRIALVHHVPFAFAHQLTLGSRIEEAFLNTNHAKMYIAINTVAVDSCVMGKSNLYRRSDLERVDGSLKPRTHAGDEPPPERGLAAFGRFLAEDNMIAGALWHELDVRHDLSCDIALNAIGNMSLSDYVWRRVRWIRVRKHMTLAATLVEPLTESVALGAVASACLRYLFRFPAWLFIPMHFLLWILVDLDVYASLAGYPLPASKRWGFIAAWAVREVLAFPIWLLAIVGNEVDWRGTTYQVLRNGEVRRASGERGWLRWGQRARKDHYQRMELAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMQ8</accession>
    <name>W4KMQ8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle subunit SRP14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Signal recognition particle 14 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_413059</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of a fungal signal recognition particle (SRP) complex that consists of a 7SL RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SRP14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540666.1">
        <property type="nucleotide sequence ID" value="XM_009542371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMQ8"/>
    <dbReference type="FunCoup" id="W4KMQ8">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KMQ8"/>
    <dbReference type="GeneID" id="20673088"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_413059"/>
    <dbReference type="eggNOG" id="KOG1761">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094309_0_1_1"/>
    <dbReference type="InParanoid" id="W4KMQ8"/>
    <dbReference type="OrthoDB" id="19209at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003210">
        <property type="entry name" value="Signal_recog_particle_SRP14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12013">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02290">
        <property type="entry name" value="SRP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="91"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW86665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="162" mass="18634" checksum="04B747DEC8A5A9FF" modified="2014-03-19" version="1">MQLVDNDIFLTQLAALFESSKERGSIWLTHKRLTHDGEDVSMEHIDGDKELPTLIRVTDGKKTKFSTRVEPGHLDRFHSAYGALLKASMTTLRKRDKKREKQRAEQHAIRKKRLAEPIDAEGPKRGSGRKKRQRRVKAAIKQQEAKQKMAEREEAHAKGKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMS7</accession>
    <name>W4KMS7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_311214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543084.1">
        <property type="nucleotide sequence ID" value="XM_009544789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMS7"/>
    <dbReference type="STRING" id="747525.W4KMS7"/>
    <dbReference type="GeneID" id="20669851"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_311214"/>
    <dbReference type="eggNOG" id="KOG1062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1768320_0_0_1"/>
    <dbReference type="InParanoid" id="W4KMS7"/>
    <dbReference type="OrthoDB" id="29308at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="147" mass="16317" checksum="7B6D3C241ED4E133" modified="2014-03-19" version="1">MDIGPFISSGALSRSHYTLVRNVEGASTSQEADGYLLAEVGKLRDRLSLPGLSSRQCKECFVLILYCSMSVTSNILANQVEFALHHAVNLAEAGSTIHERRIGIQFRVALCVYLTVYDTVGYSFCAEIMPPNHELHLMLVNTLRKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KN56</accession>
    <name>W4KN56_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-MPP</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Inactive zinc metalloprotease alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_153786</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541085.1">
        <property type="nucleotide sequence ID" value="XM_009542790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KN56"/>
    <dbReference type="FunCoup" id="W4KN56">
        <property type="interactions" value="674"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KN56"/>
    <dbReference type="GeneID" id="20667449"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_153786"/>
    <dbReference type="eggNOG" id="KOG2067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_5_2_1"/>
    <dbReference type="InParanoid" id="W4KN56"/>
    <dbReference type="OrthoDB" id="277191at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000008">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="INSULINASE"/>
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    </dbReference>
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            <begin position="40"/>
            <end position="186"/>
        </location>
    </feature>
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        <location>
            <begin position="198"/>
            <end position="432"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW87149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="519" mass="57119" checksum="46082E1B8AF4C331" modified="2014-03-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4KN94</accession>
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    </protein>
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    </gene>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
        <subcellularLocation>
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            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="747525.W4KN94"/>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_308150"/>
    <dbReference type="eggNOG" id="ENOG502S0A5">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007533_1_0_1"/>
    <dbReference type="InParanoid" id="W4KN94"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Golgi-autophagy_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157:SF25">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01465">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00755">
        <property type="entry name" value="Grip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="620"/>
        </location>
    </feature>
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            <begin position="526"/>
            <end position="574"/>
        </location>
    </feature>
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            <end position="100"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="402"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
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            <end position="525"/>
        </location>
    </feature>
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        <location>
            <begin position="535"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW87288.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="621" mass="70673" checksum="337BF20F97F49CAB" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_59579"/>
    <dbReference type="eggNOG" id="ENOG502QTP8">
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    <dbReference type="HOGENOM" id="CLU_041176_0_0_1"/>
    <dbReference type="InParanoid" id="W4KNP6"/>
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    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="Gene3D" id="3.40.50.1820">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
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    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF10">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="55"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW87463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="565" mass="60483" checksum="6A102FE8D788A88E" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNU8</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">HETIRDRAFT_248238</name>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541277.1">
        <property type="nucleotide sequence ID" value="XM_009542982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNU8"/>
    <dbReference type="STRING" id="747525.W4KNU8"/>
    <dbReference type="GeneID" id="20669237"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_248238"/>
    <dbReference type="eggNOG" id="ENOG502SBHE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173512_1_0_1"/>
    <dbReference type="InParanoid" id="W4KNU8"/>
    <dbReference type="OrthoDB" id="5555533at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037652">
        <property type="entry name" value="Mim2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28230">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28230:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19117">
        <property type="entry name" value="Mim2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW87369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="63" mass="7518" checksum="838CDD17C686ECE3" modified="2014-03-19" version="1" fragment="single">SSDGSYDSDDERLAQEEWEESLEQLAQLVSVVLLPFFGKWLGRRWSYWAYARYLEHGISRPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNW4</accession>
    <name>W4KNW4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_167059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541395.1">
        <property type="nucleotide sequence ID" value="XM_009543100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNW4"/>
    <dbReference type="GeneID" id="20668099"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_167059"/>
    <dbReference type="HOGENOM" id="CLU_050560_0_0_1"/>
    <dbReference type="InParanoid" id="W4KNW4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="479" mass="52798" checksum="E2B1068F50715836" modified="2014-03-19" version="1">MLLHDDHDALSPSRNSSPDVVLMVANPDVERVERGTSPHRPDAGRIDRGTSPQQPGSTGVLLTPHHNNFSDDDTEDYAKFKERERTRRPSPERASRDAPRHENPDDRNQPSLGQLPVGVPPPSEGTPNSGVAGPSGFRARTAAQLPSHGEVEPIPVLSETASPPVPTSGPIPSSMGGPTPRTNPHAGELERHADALLQRNTISAVIQMATAMALQRLANFSAGQPGNEHSDVPRRLASASLQIRTLALQTDPDTASWYAHNDGRPRALLIHPDEFSQYVNRELLPALLFGGELGNVQPSRTDPFRVVTWNVPRPGEHPAPVPNPRRVPRTVVERPPPGQREIPTAHSHTATPSSHRVRSFPVSQGNTNEEEPPVYRRNEGRRSRGNQATLGRGTTAGRSVRHRPRSPPPSARFRMNERPDNRSSRRTRRVDSETRRNSSWTRSELDAWDALDDPGNYDEADPYYRPDEGGGDYQGPFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4KP06</accession>
    <name>W4KP06_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Translin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_469678</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541439.1">
        <property type="nucleotide sequence ID" value="XM_009543144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KP06"/>
    <dbReference type="FunCoup" id="W4KP06">
        <property type="interactions" value="461"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KP06"/>
    <dbReference type="GeneID" id="20677301"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_469678"/>
    <dbReference type="eggNOG" id="KOG3066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067225_2_0_1"/>
    <dbReference type="InParanoid" id="W4KP06"/>
    <dbReference type="OrthoDB" id="31005at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14820">
        <property type="entry name" value="TRAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="251"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW87547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="32624" checksum="50AD73FE51F6C88D" modified="2014-03-19" version="1">MSVPDDDNARSAILRTFVAFREELDDYNDRRERLIKSSRDITNLSKKVIFLLHRVINTDSASDDRTLSLHAAQEGRKKLGEVQLLFKAMRPELTGDRFWRYQHSVSPGLQEYIEALSFAYYIEHGMLITYADVQRSLSDEEDGLYFPLPVSDYLLGVSDLTGELMRFAISSISKRGPGRSKASEVSSFVRGCKADFDGFTPHVRELSKKQHVTQQSLLKIEQAAYTITVRSSEYDLPPEMLDDIVGRHISRFSHGHPADRGTDYPSSSRKRHRHGGDSDDERDLDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPE7</accession>
    <name>W4KPE7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_246195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541464.1">
        <property type="nucleotide sequence ID" value="XM_009543169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPE7"/>
    <dbReference type="STRING" id="747525.W4KPE7"/>
    <dbReference type="GeneID" id="20669106"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_246195"/>
    <dbReference type="eggNOG" id="KOG0582">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="InParanoid" id="W4KPE7"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047173">
        <property type="entry name" value="STRAD_A/B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014:SF21">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW87579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="308" mass="33886" checksum="9E4EC7D108A3B621" modified="2014-03-19" version="1" fragment="single">MSLSKHPNVLRVRGSWIDGHKLFIALRLMNAGSAADVMRYAWPGGMHEDVVRCILNQALQGLNYLHINGFIHRDVKAANLLIDDDGTVLLGDLGVAAPLHDEDHPHSPPLPSPSPSPKPPAPRPDRAIHFDPAARRPRPGKRRSFVGTVLRAHPRSRAQPCWMAPELIAGKHYDASADIWSFGITALELAQGRAPHSRESSRTVLLRTVQGAPPTLDREGGVHKYSRAFKEMVEGCLDKDPANRPTAEQLLQTPFFRNSKKKSYLVGTLLVGLPPIAQRLERLRQPSLLPHGTVDAWDFPASAAPTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPN9</accession>
    <name>W4KPN9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_431953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541553.1">
        <property type="nucleotide sequence ID" value="XM_009543258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPN9"/>
    <dbReference type="STRING" id="747525.W4KPN9"/>
    <dbReference type="GeneID" id="20674579"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_431953"/>
    <dbReference type="HOGENOM" id="CLU_1602941_0_0_1"/>
    <dbReference type="InParanoid" id="W4KPN9"/>
    <dbReference type="OrthoDB" id="3206101at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="166" mass="18373" checksum="FCBA9E9AADC73EA2" modified="2014-03-19" version="1" fragment="single">MSTVLSIAGPRITFTHQCVPIVFPTMTIGFLIGPLSLDILLFSLTMKKFFLSMRDIRAPPWVTRFMQDGVWAFLLPLLIALVNIACMMFLHSAYSSVAFSWSIAIPGFAGYRLILHLRKCAPQDRSLSETGGDIEFDTIAITNGTSESETVVMHSEYVSRSPPIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4KQZ8</accession>
    <name>W4KQZ8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_470016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541668.1">
        <property type="nucleotide sequence ID" value="XM_009543373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KQZ8"/>
    <dbReference type="GeneID" id="20677319"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_470016"/>
    <dbReference type="HOGENOM" id="CLU_1224910_0_0_1"/>
    <dbReference type="InParanoid" id="W4KQZ8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW87810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="226" mass="25240" checksum="DE65CB2C9E26C531" modified="2014-03-19" version="1">MMVRSSDGHSHVLRACAHHRTERPASPLSWGLSRRRRRRRVAEVQDALALLEACHSSSVGAANLTWRRLRFPSSCAIAPCAVHEWQGWEIQLSKGRACLDTFWPRLTVLSTRCHGTTANVLGGKRHACTWLSALPFRIFNISNLDAATTGTTTTLPCRNSSAFRLIQVRIYQHSARHISRLCVPTRNGNEMSTGLRHRSRCARRDKVLQGATHLAISGGAGDFRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W4KRT3</accession>
    <name>W4KRT3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Vacuolar protein sorting-associated protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HETIRDRAFT_470008</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endosome membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1 10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the VPS27 family.</text>
    </comment>
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        <property type="protein sequence ID" value="ETW87771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009543340.1"/>
    </dbReference>
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        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KRT3"/>
    <dbReference type="GeneID" id="20677318"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_470008"/>
    <dbReference type="eggNOG" id="KOG1818">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011862_1_0_1"/>
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    <dbReference type="OrthoDB" id="957735at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:protein targeting to vacuole"/>
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    </dbReference>
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        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="FYVE_spVPS27p_like"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_FYVE"/>
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        <property type="entry name" value="Znf_FYVE-rel"/>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Hrs_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_FYVE"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0967">Endosome</keyword>
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    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VHS" evidence="14">
        <location>
            <begin position="30"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="13">
        <location>
            <begin position="172"/>
            <end position="232"/>
        </location>
    </feature>
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            <end position="256"/>
        </location>
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            <end position="503"/>
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            <end position="573"/>
        </location>
    </feature>
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        <location>
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            <end position="627"/>
        </location>
    </feature>
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        <location>
            <begin position="645"/>
            <end position="692"/>
        </location>
    </feature>
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        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
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        <location>
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            <end position="556"/>
        </location>
    </feature>
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        <location>
            <begin position="589"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
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            <begin position="649"/>
            <end position="663"/>
        </location>
    </feature>
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        <location>
            <begin position="664"/>
            <end position="680"/>
        </location>
    </feature>
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            <begin position="681"/>
            <end position="692"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="ETW87771.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
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    </evidence>
    <sequence length="692" mass="76477" checksum="01B025E5BB2080BB" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNG0</accession>
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        </lineage>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
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        </location>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
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    <accession>W4JNN5</accession>
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        <submittedName>
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            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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                <person name="Martin F."/>
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                <person name="Stenlid J."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_120386"/>
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    <dbReference type="InParanoid" id="W4JNN5"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="107" mass="12028" checksum="FA486634B7A28AC6" modified="2014-03-19" version="1">MPVWHKISKLRSAEGHAEREAKAARKQTLAEDRSDAECIMVRKKADDARKCSEARGGNDRTENDRHRDILRGVTPVAVKVKMEMGTVCLKANERVAVIEKVYRGPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
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    <name>W4JNW0_HETIT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">HETIRDRAFT_330730</name>
    </gene>
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            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
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                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNW0"/>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_330730"/>
    <dbReference type="HOGENOM" id="CLU_3050593_0_0_1"/>
    <dbReference type="InParanoid" id="W4JNW0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="54" mass="5941" checksum="1C99F640ED47E3EF" modified="2014-03-19" version="1">MGDLSGFGNAISQTQSLEFAMMPLKVHFTQPTESQKDEVDESSDMSYCKHAGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQ42</accession>
    <name>W4JQ42_HETIT</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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        <lineage>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551919.1">
        <property type="nucleotide sequence ID" value="XM_009553624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQ42"/>
    <dbReference type="GeneID" id="20676615"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_455375"/>
    <dbReference type="HOGENOM" id="CLU_1434610_0_0_1"/>
    <dbReference type="InParanoid" id="W4JQ42"/>
    <dbReference type="OrthoDB" id="3235454at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="189" mass="21294" checksum="D1F5F70396D5F2D1" modified="2014-03-19" version="1">MPVVKDTTKSKKQKRDANLDARSDDLDASQVSIGSDETRMASVLAEQMRKSADKKQKLREAKFLQAMKRELAKAMTLRGKEMSAISDELTGQSEKYAMAYAENEDCIRGILSEIMKEREKITELVKRREALHSEESAQMERDSVAGLASVKRRCEGAQRQSPPTPSVAPYMRSRARRDFHVPIQDTTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQE5</accession>
    <name>W4JQE5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="6 7">
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="ETW75704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009553547.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="W4JQE5">
        <property type="interactions" value="702"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JQE5"/>
    <dbReference type="GeneID" id="20671950"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_37903"/>
    <dbReference type="eggNOG" id="KOG1896">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002414_0_0_1"/>
    <dbReference type="InParanoid" id="W4JQE5"/>
    <dbReference type="OrthoDB" id="6109at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="4">
        <location>
            <begin position="129"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="5">
        <location>
            <begin position="594"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="3">
        <location>
            <begin position="1082"/>
            <end position="1409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW75704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1441" mass="158871" checksum="EEE19205E3550D12" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRZ5</accession>
    <name>W4JRZ5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_330321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRIAP1/MDM35 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551922.1">
        <property type="nucleotide sequence ID" value="XM_009553627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRZ5"/>
    <dbReference type="FunCoup" id="W4JRZ5">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JRZ5"/>
    <dbReference type="GeneID" id="20671568"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_330321"/>
    <dbReference type="eggNOG" id="KOG3481">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101473_1_0_1"/>
    <dbReference type="InParanoid" id="W4JRZ5"/>
    <dbReference type="OrthoDB" id="19091at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990050">
        <property type="term" value="F:phosphatidic acid transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007918">
        <property type="entry name" value="MDM35_apoptosis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403:SF1">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05254">
        <property type="entry name" value="UPF0203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW75656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="108" mass="12129" checksum="87FA0DBF9BF4C7AB" modified="2014-03-19" version="1">MAHSLTDECTPLKLEYDSCFNSWFEGYLEPAVSASASPDQRAKYSKAKAEEYERKCGKIWASYRDCVQKAVKERGLDELLDQARKENPLTDPPSTTPTSTESSSTSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRZ7</accession>
    <name>W4JRZ7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="7 11">3.13.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_412215</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.13.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="10 11">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="EC" id="3.13.2.1" evidence="7 11"/>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552110.1">
        <property type="nucleotide sequence ID" value="XM_009553815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRZ7"/>
    <dbReference type="FunCoup" id="W4JRZ7">
        <property type="interactions" value="522"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JRZ7"/>
    <dbReference type="GeneID" id="20673007"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_412215"/>
    <dbReference type="eggNOG" id="KOG1370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025194_2_1_1"/>
    <dbReference type="InParanoid" id="W4JRZ7"/>
    <dbReference type="OrthoDB" id="10007170at2759"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1480:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="13">
        <location>
            <begin position="189"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="155"/>
            <end position="157"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="220"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="297"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW75870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="430" mass="46890" checksum="2DB56F8FBEC7E51A" modified="2014-03-19" version="1">MVFKVADISLAAFGRKEIEIAENEMPGLMYLRKKHGAAQPLKGARIAGCLHMTIQTAVLIETLTALGAEVAWSSCNIFSTQDHAASAIAATGVPVFAWKGETEEEYTWCIEQTLSAFSGNQPLNLILDDGGDLTTLVHEKYPQFLKGIKGVSEETTTGVHHLYKAFRDGKLKVPAINVNDSVTKSKFDNYYGCRESLVDGIKRATDVMLAGKVAVVAGFGDVGKGCAESLRSYGARVLITEIDPINALQAAMAGYEVTTMEDAAPRANVFVTTTGNRDIITAKHFEAMPEDAIVSNIGHFDVEIDVAWLKANAKQVINVKPQVDRYTMASGRHIILLAEGRLVNLGCATGHPSFVMSCSFTNQVLAQIALWTTPEKFPLGVHMLPKELDEEVARAHLKTLNVKLTTLSDVQSKYLDLPVNGPYKADHYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JT76</accession>
    <name>W4JT76_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_330473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552311.1">
        <property type="nucleotide sequence ID" value="XM_009554016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JT76"/>
    <dbReference type="GeneID" id="20671579"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_330473"/>
    <dbReference type="HOGENOM" id="CLU_193161_0_0_1"/>
    <dbReference type="InParanoid" id="W4JT76"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="69" mass="8110" checksum="D95A72CFE45A6138" modified="2014-03-19" version="1">MLADVFCESVGPYRLSSRLPHGWSNTILHHYLATLVVRYVFFIFIDSPTLVPTIYTWVTDPECSRFHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTB6</accession>
    <name>W4JTB6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_328569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551587.1">
        <property type="nucleotide sequence ID" value="XM_009553292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTB6"/>
    <dbReference type="STRING" id="747525.W4JTB6"/>
    <dbReference type="GeneID" id="20671422"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_328569"/>
    <dbReference type="HOGENOM" id="CLU_2469373_0_0_1"/>
    <dbReference type="InParanoid" id="W4JTB6"/>
    <dbReference type="OrthoDB" id="10453604at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="88" mass="9768" checksum="C9E64C7255C6AE7D" modified="2014-03-19" version="1">MSVTGLPLLDPLVKANAKRTYSVFASCPDAGIREEEKSARLRLAVKINDEYKHYKQLPSALLEQQAPVGPARPKDQRKMITAGRTSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTR7</accession>
    <name>W4JTR7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_389878</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551706.1">
        <property type="nucleotide sequence ID" value="XM_009553411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTR7"/>
    <dbReference type="SMR" id="W4JTR7"/>
    <dbReference type="STRING" id="747525.W4JTR7"/>
    <dbReference type="GeneID" id="20672427"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_389878"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_3_0_1"/>
    <dbReference type="InParanoid" id="W4JTR7"/>
    <dbReference type="OrthoDB" id="10266508at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06225">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000003">
        <property type="entry name" value="Atypical/HisK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1530">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
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        <location>
            <begin position="8"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="101"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="193"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="285"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="377"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="469"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="562"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="636"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="12">
        <location>
            <begin position="1006"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="10">
        <location>
            <position position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW76839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1148" mass="124510" checksum="693A03E7D2A01F72" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTT5</accession>
    <name>W4JTT5_HETIT</name>
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        <recommendedName>
            <fullName evidence="1">ARF GTPase-activating protein GIT1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_454415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_454415"/>
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    <dbReference type="OrthoDB" id="5588096at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022018">
        <property type="entry name" value="GIT1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12205">
        <property type="entry name" value="GIT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="9"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="98" mass="10385" checksum="839B0BE13C6C49D2" modified="2014-03-19" version="1">MLSNDSAPSLEAQTESIVYTIQSVLSGVRSPTPSPMPSPTVNENLTQTITIVSSIVAVCHDNLPPASAQQGNDILRELSNHANKLSEVQAMRDNLGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTX9</accession>
    <name>W4JTX9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_455084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EMC8/EMC9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551445.1">
        <property type="nucleotide sequence ID" value="XM_009553150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTX9"/>
    <dbReference type="STRING" id="747525.W4JTX9"/>
    <dbReference type="GeneID" id="20676583"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_455084"/>
    <dbReference type="eggNOG" id="KOG3289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087337_0_1_1"/>
    <dbReference type="InParanoid" id="W4JTX9"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08060">
        <property type="entry name" value="MPN_UPF0172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005366">
        <property type="entry name" value="EMC8/9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941:SF10">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 8_9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03665">
        <property type="entry name" value="UPF0172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="2">
        <location>
            <begin position="4"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW76555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="200" mass="21643" checksum="7C08F5047B120986" modified="2014-03-19" version="1">MANYTISDLAYTKIVLHSLKHPQHPVNGVLLGAKDTKGVQVVDTIPLLHHWTSLSPMMEIGLDLANGHAESRGLALVGYYQASERVDDNTLKPVGERVATKVREGFPDALAVVVDGTKLGSETDPALVPYLPTSGSSTTFRSAPPTILTLSNSAPALSLHLSRARVPFSDFDDHLEDVRLDWLQNEQVEEALKGVKVVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4JU77</accession>
    <name>W4JU77_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trafficking protein particle complex subunit 2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_52336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. Sedlin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550496.1">
        <property type="nucleotide sequence ID" value="XM_009552201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JU77"/>
    <dbReference type="FunCoup" id="W4JU77">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JU77"/>
    <dbReference type="GeneID" id="20678212"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_52336"/>
    <dbReference type="eggNOG" id="KOG3444">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085828_2_1_1"/>
    <dbReference type="InParanoid" id="W4JU77"/>
    <dbReference type="OrthoDB" id="18320at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14854">
        <property type="entry name" value="TRAPPC2L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044760">
        <property type="entry name" value="TRAPPC2L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW77014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="164" mass="17814" checksum="F06ECEEDDA9A07A9" modified="2014-03-19" version="1">MAPHLGLAAVAFVSPQNHPILVRSFSQTHDDLLKYHYIAHTSLDVVDERIAAAPKSVECYLGFLYSMEDVAVYAYITPPKVKIILALALTDAVVRDADIITIFKALHLAYYRSAANPFLRLNLAPDAAADHGTLLLAGSTRWTAFRTRVDDVARAAGAVALPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4JU84</accession>
    <name>W4JU84_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription regulator Rua1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_244264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551343.1">
        <property type="nucleotide sequence ID" value="XM_009553048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JU84"/>
    <dbReference type="STRING" id="747525.W4JU84"/>
    <dbReference type="GeneID" id="20669035"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_244264"/>
    <dbReference type="eggNOG" id="ENOG502R0SR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154975_0_0_1"/>
    <dbReference type="InParanoid" id="W4JU84"/>
    <dbReference type="OrthoDB" id="5595379at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028012">
        <property type="entry name" value="Rua1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28125">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28125:SF2">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14616">
        <property type="entry name" value="Rua1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator Rua1 C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW76436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="87" mass="9873" checksum="69CE1623EF109F8F" modified="2014-03-19" version="1" fragment="single">GISPTTGLPFSPPTAFRTHVRPNPGKHERATLREARCHRCRQWVAVEGVKDVEPKVKEIYWWKHAAACHHGSTIDGESDVFVHDDVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUG1</accession>
    <name>W4JUG1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_326537</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550727.1">
        <property type="nucleotide sequence ID" value="XM_009552432.1"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JUG1"/>
    <dbReference type="GeneID" id="20671250"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_326537"/>
    <dbReference type="eggNOG" id="KOG0271">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_6_0_1"/>
    <dbReference type="InParanoid" id="W4JUG1"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="5">
        <location>
            <begin position="445"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="928"/>
            <end position="962"/>
        </location>
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            <end position="1005"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1007"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1074"/>
            <end position="1109"/>
        </location>
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            <end position="1149"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="1226"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="1320"/>
            <end position="1345"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW77187.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1391" mass="153271" checksum="A1EB7B3A9CDE9B0F" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
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        <name evidence="2" type="ORF">HETIRDRAFT_480677</name>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_480677"/>
    <dbReference type="eggNOG" id="KOG4476">
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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    </dbReference>
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        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
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        </location>
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            <begin position="1"/>
            <end position="18"/>
        </location>
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        </location>
    </feature>
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            <end position="383"/>
        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUS0</accession>
    <name>W4JUS0_HETIT</name>
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        <recommendedName>
            <fullName evidence="12">Probable threonine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HETIRDRAFT_65578</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009552231.1"/>
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    </dbReference>
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    <dbReference type="GeneID" id="20678743"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_65578"/>
    <dbReference type="eggNOG" id="KOG1637">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008554_0_1_1"/>
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    <dbReference type="OrthoDB" id="5423599at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000019">
        <property type="entry name" value="Threonine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000006">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000005">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="15">
        <location>
            <begin position="80"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="341"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETW77277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="739" mass="83690" checksum="303FACA6D75C6433" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUY9</accession>
    <name>W4JUY9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein BTN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_52504</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the battenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550501.1">
        <property type="nucleotide sequence ID" value="XM_009552206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUY9"/>
    <dbReference type="FunCoup" id="W4JUY9">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JUY9"/>
    <dbReference type="GeneID" id="20678217"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_52504"/>
    <dbReference type="eggNOG" id="KOG3880">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029663_3_1_1"/>
    <dbReference type="InParanoid" id="W4JUY9"/>
    <dbReference type="OrthoDB" id="5965864at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW77378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="449" mass="48767" checksum="D571BB606AA2A4A2" modified="2014-03-19" version="1">MSAEKPGPLLRLGVSFFLFGVINNVLYVIILSAALDLVPTSTPKGIILFCNIAPALLAKIGWPYLLKGRIHYARRLFGCCTLSVAGMIVVAAFESLPGRLLGISFASFSSGLGELTFLQLSTTYHPPSVGGHSVGYFASGTGAAGLLGAFLWWEVRSLGVRVGVGLSAVLPFITPLTYLLVLPRPSAFASVAFSSLNDGDSDGALPVPYTSLPTIDEDTIEQEQERFTHSKTDTVLSLAEKWRLAKPLLLRYMLPLFCVYLFEYTINQGIAPTLIYPVPSGDSHSVLGNIIHSIRDYYPLWQLVYQTTVFLSRSTISLGLPPLPSRLLSLPAVVQALILLTLMYESAIGFFSDASEGINVFMVFLLISLEGICGGLAYVNVFYRINQEQSKTDPSIDPERAKQEKEFKIGSIGLSDSLGILIASLVAMPTEIELCNAQVRRGKMLCRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWD8</accession>
    <name>W4JWD8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative thaumatin PR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_326935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550909.1">
        <property type="nucleotide sequence ID" value="XM_009552614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWD8"/>
    <dbReference type="STRING" id="747525.W4JWD8"/>
    <dbReference type="GeneID" id="20671282"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_326935"/>
    <dbReference type="eggNOG" id="ENOG502QUID">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043181_4_0_1"/>
    <dbReference type="InParanoid" id="W4JWD8"/>
    <dbReference type="OrthoDB" id="430315at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001938">
        <property type="entry name" value="Thaumatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31048">
        <property type="entry name" value="OS03G0233200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00314">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002703">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00347">
        <property type="entry name" value="THAUMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00205">
        <property type="entry name" value="THN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51367">
        <property type="entry name" value="THAUMATIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845009" evidence="2">
        <location>
            <begin position="23"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="31"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="99"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="152"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="157"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR002703-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW77400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="259" mass="27079" checksum="8842FE4253F98843" modified="2014-03-19" version="1">MAFSLTALAFSLFAGLAQTTDARTFTVVNACPFTIWPAIFTDLTVAPNVPQFPTGWQAAPSNSVSFEVPDNWKSGRIWGRRDCDFTTNPGPNSCLDGGCNGGLLCDPHTGTGVPPATVAEWTLQGDGGRDFYDVSLVDGYNLPMAITNNANCPVADCPVDLGPDCPTPLIGPFDSTGFPVGCKSACSANLDGTPNDSANCCSGSHSTAATCPSSGVAFYSYFKGNCPNSYAYAFDESSNTALWTCSSSANPDFTLTFCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWE0</accession>
    <name>W4JWE0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_325274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549802.1">
        <property type="nucleotide sequence ID" value="XM_009551507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWE0"/>
    <dbReference type="GeneID" id="20671133"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_325274"/>
    <dbReference type="HOGENOM" id="CLU_976797_0_0_1"/>
    <dbReference type="InParanoid" id="W4JWE0"/>
    <dbReference type="OrthoDB" id="6910977at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW77769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="285" mass="31789" checksum="7525DC0917B044CF" modified="2014-03-19" version="1">MYTASYIQSDLYSLNPLGREPADIPDYPLGGITSNVIPEGIAFMNYGNDTYHSPYVPADTNSDELMEFFPSIQPEPTILDNFPDETGLLEAFQSHHMIPQIADFSSTGYDFSLTHRQDQPSDVRSFDWLIDQDQFEIDNIGYSVASFTAKPAPSGIVGIRPHLEGSAFSESSLSYDSGLDHPSSCTPDEFTESNSGTQPEAQSCVSNIVTSPEERAFPEETKSPAHNICGVCLRRCSTPWNSKEHVETHNPERVKQHVCTIEGCEYASRRKNDVERHMKSRKHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWK8</accession>
    <name>W4JWK8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_181163</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550977.1">
        <property type="nucleotide sequence ID" value="XM_009552682.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="W4JWK8">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JWK8"/>
    <dbReference type="GeneID" id="20668583"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_181163"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_17_2_1"/>
    <dbReference type="InParanoid" id="W4JWK8"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000218">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001471">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF15">
        <property type="entry name" value="ALPHA-FACTOR-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="926"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="968"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1041"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1071"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1155"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1184"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="71"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="436"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="928"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="1246"/>
            <end position="1482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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                <person name="Aerts A."/>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
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</entry>
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        <source>
            <dbReference type="EMBL" id="ETW78193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
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    <accession>W4JXC2</accession>
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                <person name="Hansson D."/>
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                <person name="Hogberg N."/>
                <person name="James T.Y."/>
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                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_454230"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="12991" checksum="484003727927C857" modified="2014-03-19" version="1">MSGQASTFTDTPPTTVQSGRGKVKLPDNYTGDHIESQKFMLQCLLLFTAESDRYKTDQDKISLVLSCMRYGTAGAWVENFLLKSVGVDPPTDLGTWMNFLAKFRLQFRETGKTNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXD3</accession>
    <name>W4JXD3_HETIT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_429265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXD3"/>
    <dbReference type="GeneID" id="20674333"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_429265"/>
    <dbReference type="HOGENOM" id="CLU_1428168_0_0_1"/>
    <dbReference type="InParanoid" id="W4JXD3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="190" mass="20507" checksum="C2E32099CE432068" modified="2014-03-19" version="1">MGPTVFGKVSVFGTCRALFGISPKLPEYLPLTLARVHAHQRDVLRDMFSNEEESWKELSVDILRELIRVDEESLWSSVIMFVPGGCVRVGLEGEHSDLETGASQSSRLPCQKVSESLEGHGCGHLYYHGDSVALEKRVFLAHNPKGPAAPTFVVTPVGSGTPTGSLSVPASSSEKLLRFGVRTAMVGSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4JY21</accession>
    <name>W4JY21_HETIT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_67367</name>
    </gene>
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        <lineage>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549681.1">
        <property type="nucleotide sequence ID" value="XM_009551386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JY21"/>
    <dbReference type="STRING" id="747525.W4JY21"/>
    <dbReference type="GeneID" id="20678807"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_67367"/>
    <dbReference type="eggNOG" id="ENOG502SSN3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144328_0_0_1"/>
    <dbReference type="InParanoid" id="W4JY21"/>
    <dbReference type="OrthoDB" id="2550823at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="149" mass="16220" checksum="3E58496B3E0654BF" modified="2014-03-19" version="1">MSQQLTAQSPLSAVFLLHIALEIPLAIQGLWAPQGLPFLELNNTTLVFVKLYAALSLATCIACLLVHSLPEFLPGKRALAIALCVHHSIVSTVLFQAPRFIPHSFGQLAEGYKFTPEILWGGLHGVLSLGMVAWWQGTVAYAAMARKMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4JY44</accession>
    <name>W4JY44_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_172076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548839.1">
        <property type="nucleotide sequence ID" value="XM_009550544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JY44"/>
    <dbReference type="STRING" id="747525.W4JY44"/>
    <dbReference type="GeneID" id="20668385"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_172076"/>
    <dbReference type="eggNOG" id="KOG0206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_969967_0_0_1"/>
    <dbReference type="InParanoid" id="W4JY44"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="287" mass="31598" checksum="33ED7B80D2A117DC" modified="2014-03-19" version="1">MQPCHPVPSRSSPRRFTSPPLPRAASPPKPCARSPLCTLAPRILVLSAVDVPTVEVAIFISVGTNHFLNTTAPASARERDVLVEFLTLLAVCHTVIPELKDGKTQYQASSPDKAALVAGAELLGLQFRTRKPKSVFVDVLGASQEYQILNVCEFNSTRKRMSTVVRAPDGRIKLCKGADAVIFERLSKIQPYSKNTLVHLEDYATEGLRTLCIAYRDIPESKYKQWSAHGHGRPRSRTPLHTNSHRSCSRSSLLSLDEILLRVAINDRSRAGSLINAPSRPRPSPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYK0</accession>
    <name>W4JYK0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_147254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548969.1">
        <property type="nucleotide sequence ID" value="XM_009550674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYK0"/>
    <dbReference type="STRING" id="747525.W4JYK0"/>
    <dbReference type="GeneID" id="20667190"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_147254"/>
    <dbReference type="HOGENOM" id="CLU_1949087_0_0_1"/>
    <dbReference type="InParanoid" id="W4JYK0"/>
    <dbReference type="OrthoDB" id="3069854at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="129" mass="13449" checksum="9BD0FC37CD0A1928" modified="2014-03-19" version="1">MTLVMSLTAGGMAGQSPMPVQPQNGYQEGNQGWAAGPTSQNGNWQGTRGGGHFPRGGRGGYMYGSGREEQGQWGYQMNEQASDAIVLGGDTDPVPLPESDTETGIGGVPAGRMQRVGDRWMFVRAGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZA4</accession>
    <name>W4JZA4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_50367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548779.1">
        <property type="nucleotide sequence ID" value="XM_009550484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZA4"/>
    <dbReference type="GeneID" id="20678144"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_50367"/>
    <dbReference type="HOGENOM" id="CLU_2460740_0_0_1"/>
    <dbReference type="InParanoid" id="W4JZA4"/>
    <dbReference type="OrthoDB" id="2205812at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31635:SF196">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="89" mass="10386" checksum="D9880C91BD9E3F14" modified="2014-03-19" version="1" fragment="single">TLTIVYRDIQEKGVNTNSNFTLGWMCLIYKKHKRSSIENYRPITLLNLDYKLLMRVLAMQLAVVIPSLIHKNQAGFITERSIFDQTRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZA6</accession>
    <name>W4JZA6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_441042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549094.1">
        <property type="nucleotide sequence ID" value="XM_009550799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZA6"/>
    <dbReference type="GeneID" id="20675321"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_441042"/>
    <dbReference type="HOGENOM" id="CLU_2386443_0_0_1"/>
    <dbReference type="InParanoid" id="W4JZA6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="94" mass="10150" checksum="6AA2D2F5CCDCBA1E" modified="2014-03-19" version="1">MTCQVGVFTLRPFVQQGPLQDRSSSAAIQIFRHRCGAVRGPGLVAPPTSERGDLHTLLHSLTLRACFVPSLAILGLVLIHLLFSPIFLVIPAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZC4</accession>
    <name>W4JZC4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_428667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549187.1">
        <property type="nucleotide sequence ID" value="XM_009550892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZC4"/>
    <dbReference type="GeneID" id="20674294"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_428667"/>
    <dbReference type="eggNOG" id="ENOG502SRIE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_445529_0_0_1"/>
    <dbReference type="InParanoid" id="W4JZC4"/>
    <dbReference type="OrthoDB" id="5596707at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="613" mass="67374" checksum="098E57A7C9610828" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZS2</accession>
    <name>W4JZS2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_420251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549342.1">
        <property type="nucleotide sequence ID" value="XM_009551047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZS2"/>
    <dbReference type="GeneID" id="20673639"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_420251"/>
    <dbReference type="HOGENOM" id="CLU_2038371_0_0_1"/>
    <dbReference type="InParanoid" id="W4JZS2"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845069" description="Secreted protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13173" checksum="B58FCF9DA7703AA5" modified="2014-03-19" version="1">MWVVCFPFVWLIGAGAKPSVLFCPLMVGVGARGGVQSWILRDVLLSVPCPLTYPPPCPVPDAARLFFPRNVDSVFSGLVPVLFYFHHLRANEPQVVDTLRCCVTVPELGALGIFNPAAHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0E8</accession>
    <name>W4K0E8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_50273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548771.1">
        <property type="nucleotide sequence ID" value="XM_009550476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0E8"/>
    <dbReference type="GeneID" id="20678136"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_50273"/>
    <dbReference type="eggNOG" id="ENOG502SJQ6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007279_3_1_1"/>
    <dbReference type="InParanoid" id="W4K0E8"/>
    <dbReference type="OrthoDB" id="2745718at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="517" mass="58859" checksum="9876754FFDE7F7B3" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0V0</accession>
    <name>W4K0V0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA ligase</fullName>
            <ecNumber evidence="16">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HETIRDRAFT_151541</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="16"/>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549244.1">
        <property type="nucleotide sequence ID" value="XM_009550949.1"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K0V0"/>
    <dbReference type="GeneID" id="20667391"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_151541"/>
    <dbReference type="eggNOG" id="KOG0966">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3818">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_253466_0_0_1"/>
    <dbReference type="InParanoid" id="W4K0V0"/>
    <dbReference type="OrthoDB" id="151490at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07903">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18435">
        <property type="entry name" value="BRCT_BRC1_like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044125">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
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    </dbReference>
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    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="7" id="KW-0677">Repeat</keyword>
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            <begin position="384"/>
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        </location>
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        </location>
    </feature>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="18">
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        </location>
    </feature>
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            <begin position="780"/>
            <end position="882"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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            <end position="876"/>
        </location>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004196"/>
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        </source>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
    <sequence length="1414" mass="161843" checksum="4483E6AF5AF901E1" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1H4</accession>
    <name>W4K1H4_HETIT</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">HETIRDRAFT_324422</name>
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        </lineage>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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            <end position="130"/>
        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="130" mass="14402" checksum="B2FC92476E5E80D0" modified="2014-03-19" version="1" fragment="single">LGAHSTSTLISGSIFYLGALFTIKTYIQLWNKPAFAPHSSELIRIRLNHRNRLCQPPKTCHPRRSASFVSVLVSSLVPPSSLVYCQSPVWLLKHVVVGRDTTFSLPTASPTRPTEHSVGVRRSPETVRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
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        </lineage>
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                <person name="Asiegbu F."/>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
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                <person name="Gonthier P."/>
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                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
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                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
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                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Lucas S."/>
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                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="22463738"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="747525.W4K211"/>
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    <dbReference type="eggNOG" id="ENOG502RG16">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38406:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08618">
        <property type="entry name" value="Opi1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
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            <end position="658"/>
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        </source>
    </evidence>
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    <sequence length="683" mass="70684" checksum="71C108400D6C1D52" modified="2014-03-19" version="1"> </sequence>
</entry>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
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                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
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                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
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                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
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                <person name="Velez H."/>
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                <person name="Yakovlev I."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW79917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="62501" checksum="76FC30486D0E9D35" modified="2014-03-19" version="1"> </sequence>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Broberg A."/>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Hansson D."/>
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                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
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                <person name="Raffaello T."/>
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                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="183" mass="19699" checksum="3134383889094BFB" modified="2014-03-19" version="1">MGLTIALHHAILTPNTSNIILYADNEAALKSLLDPRVHPSQMCSILACQRLRAWLSAAPDHHLTIAWCPGHVGIPRQEQVDTLAKASLRDNPPHSSPLPSSNRKPTPPCLQHGRPSCNPPNTAAATSLGNAPSERWLPPRASPSSGSDNTICWLHADEHAPALGSEGGIREALGRYRTALDKY</sequence>
</entry>
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    <reference evidence="2 3" key="1">
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                <person name="Asiegbu F."/>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Gonthier P."/>
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                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
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                <person name="Himmelstrand K."/>
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                <person name="James T.Y."/>
                <person name="Karlsson M."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
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                <person name="Raffaello T."/>
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                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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                <person name="Martin F."/>
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            <dbReference type="PubMed" id="22463738"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_453799"/>
    <dbReference type="HOGENOM" id="CLU_1230084_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2U0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="225" mass="24461" checksum="4FB8345B367129BA" modified="2014-03-19" version="1">MLAAEGLRVAAGTAAEGGSARPSERSCRGSAQGEIRPCNPREYAGAHCRWRHARKAVALLGRVYSQPQRPHHPHQTQAIHPQCRLCAHDPIRLEQTTSTETGGRSQHAGAATHYQSPVHMTGARGGPLTVGSRWIWHAWDDARSTDQSGWVRSDHHASQAASPCQTSDSFFILRCADCVGAENWGAQSVRALLSGRALHIRVRERRDHTVCDLARTGAVPARAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2U3</accession>
    <name>W4K2U3_HETIT</name>
    <protein>
        <submittedName>
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        </submittedName>
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    </gene>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548578.1">
        <property type="nucleotide sequence ID" value="XM_009550283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2U3"/>
    <dbReference type="GeneID" id="20676336"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_453046"/>
    <dbReference type="HOGENOM" id="CLU_1321040_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2U3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW80054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="208" mass="23403" checksum="9EC577D4B888CB87" modified="2014-03-19" version="1">MSTPAFHQAGFSQLIFRKRLFVPDYASSSTPVNEVDPLGKFGAFELATSRAPLRPVHHRVLRAQAVTQMLRLLALDLSTATSAEMDGLRPRFVCEPCDAEIQRWTDCASPLTDKDFMTWRTCVRVPPPPPSRPLSRLPPITHALQQHGKPKAPRLALRSLTDEERVYCEMRKQGPHWGCARCTYHVSKSGSAGSWLYRDEIVQHVQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3I2</accession>
    <name>W4K3I2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3 7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_384908</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FKBP-type PPIase family. FKBP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3 7"/>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547150.1">
        <property type="nucleotide sequence ID" value="XM_009548855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3I2"/>
    <dbReference type="FunCoup" id="W4K3I2">
        <property type="interactions" value="152"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K3I2"/>
    <dbReference type="GeneID" id="20672220"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_384908"/>
    <dbReference type="eggNOG" id="KOG0544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013615_12_1_1"/>
    <dbReference type="InParanoid" id="W4K3I2"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000025">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050689">
        <property type="entry name" value="FKBP-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516:SF443">
        <property type="entry name" value="FK506-BINDING PROTEIN 59-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="9">
        <location>
            <begin position="20"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW80393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="108" mass="11636" checksum="E3C36FC8756EB555" modified="2014-03-19" version="1">MGVTVESISPGDGTTFPQRGDKVTIHYVGTLIDGKKFDSSRDRGSPFETEIGVGKVIKGWDEGVPRLSLGEKAILTATPDYAYGARGFPPVIPPNSTLKFEVELLKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3K0</accession>
    <name>W4K3K0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_410373</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548216.1">
        <property type="nucleotide sequence ID" value="XM_009549921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3K0"/>
    <dbReference type="STRING" id="747525.W4K3K0"/>
    <dbReference type="GeneID" id="20672858"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_410373"/>
    <dbReference type="HOGENOM" id="CLU_1168278_0_0_1"/>
    <dbReference type="InParanoid" id="W4K3K0"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="51"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW79651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="238" mass="25945" checksum="A9876A1943C57B64" modified="2014-03-19" version="1" fragment="single">MGEGENREAAGTGKKDLVGDVSPAEDTGDHPPDQIPTVVIPRFIDDHPPSPDLFLGNLPFSVNKPLVRQFFNRYGTIIDVRVAYDAHGNCAGYAHVEFASVEDALAALIVGARRGFFYGDRALRVGFGQSARAQHHGAGSGGGRGIVYDGSAERLPRMAVRSKTVYVHQWKGTEAALRDRFRNYRGFAGVFVEPPIRGKPWRAAFVQFVDVYTAERAIAYARRETRAGTGAAALELEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4D4</accession>
    <name>W4K4D4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_49510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPO2/CSE1 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_49510"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Importin-beta_N"/>
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    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
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    </feature>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="977" mass="108580" checksum="3DF940F9D8080FE5" modified="2014-03-19" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
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    </reference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_154904"/>
    <dbReference type="eggNOG" id="ENOG502QSHE">
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    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="539" mass="59061" checksum="208F2C6B3C768D19" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4W1</accession>
    <name>W4K4W1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_385468</name>
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    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
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                <person name="Raffaello T."/>
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                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_385468"/>
    <dbReference type="eggNOG" id="ENOG502S2KS">
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    <dbReference type="HOGENOM" id="CLU_087383_0_0_1"/>
    <dbReference type="InParanoid" id="W4K4W1"/>
    <dbReference type="OrthoDB" id="61370at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844078" evidence="2">
        <location>
            <begin position="24"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW80842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="214" mass="23489" checksum="606422E0B1E3C71B" modified="2014-03-19" version="1">MRKTSYAIAFVLVAATLALNILAARSNDWFVVKGEDILGTKYTVRYGLMERCEATSINIPGSNGKVTYSDYQCRPFPASVTDRCEKNNRFFCTAWTSAGYVEELGIGFGAIALLSLIFGVSTHSRRLRIWKAVAGLVALHALFPMITFAVVTDLYRTSKFSGFDHARPSFAYYLSIVSWAVAFGISFGVVLTGVSARKGHRWAAGNRAYAPIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5B1</accession>
    <name>W4K5B1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_320207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547288.1">
        <property type="nucleotide sequence ID" value="XM_009548993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5B1"/>
    <dbReference type="GeneID" id="20670654"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_320207"/>
    <dbReference type="HOGENOM" id="CLU_046025_16_2_1"/>
    <dbReference type="InParanoid" id="W4K5B1"/>
    <dbReference type="OrthoDB" id="3053835at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="128" mass="14321" checksum="36FC91269AF0C99F" modified="2014-03-19" version="1" fragment="single">ILGLVFNWGLLGVLSSQVYIYYLRYPKDSWRIKSLVYGLCIAEVIQTSLLTHDAVIVLGRGWGDITVVTDMHTLWFSGAIMNGTADAIVQLYYAWRIFILSKSIFFTAIIVLVCNTSRTSNSMCAIAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5X3</accession>
    <name>W4K5X3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_419079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547834.1">
        <property type="nucleotide sequence ID" value="XM_009549539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5X3"/>
    <dbReference type="GeneID" id="20673525"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_419079"/>
    <dbReference type="HOGENOM" id="CLU_1012139_0_0_1"/>
    <dbReference type="InParanoid" id="W4K5X3"/>
    <dbReference type="OrthoDB" id="2322499at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="275" mass="32220" checksum="35C131D93643A441" modified="2014-03-19" version="1">MWRRVKKWFKDHFWDTKSERSREIGTLKKLMKNGMTSSQTIKFVEDCAAFMDRFTRLESILRDMDTELPGVADHNYVDIALLPEIKKVLSIRYDQEISEAEWTNLRQVILAAFLRWRKDMDLSLAVFVPELTCVYRSLDTLDYPATLFWCCKCSDLGLTRAVTYVDMISHRCCNEPFDFDSTSCRFSYSYSDYHQAAVFYFWYNPWSYHCLKFHSGSYLVVDSVVTRGEHGCRASRGHIDSLRTQFKCIACTKNAPWPTADWPDVVQHVLTHSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7I5</accession>
    <name>W4K7I5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_238463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546342.1">
        <property type="nucleotide sequence ID" value="XM_009548047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7I5"/>
    <dbReference type="STRING" id="747525.W4K7I5"/>
    <dbReference type="GeneID" id="20668807"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_238463"/>
    <dbReference type="eggNOG" id="ENOG502S6XR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042081_0_0_1"/>
    <dbReference type="InParanoid" id="W4K7I5"/>
    <dbReference type="OrthoDB" id="2117972at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027948">
        <property type="entry name" value="DUF4436"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14494">
        <property type="entry name" value="DUF4436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="301" mass="33043" checksum="360D8935D1CF9499" modified="2014-03-19" version="1" fragment="single">GVVPLGAMFLIVMCVLASLFFIGTMSLVFVGGRNVVTFKSMLDELASGSPGIVLLGEDVDIDVDEPSISIRWAFVACGEAFLLPGSQGVHVGQYRPAMSPFGRDSGKRQMIQALTRFDDDHVLDVHEANLYPFDTYRLSSIVCAVNSATNETLQIQRLSTVDVTTSFTVTITDADTYNTLSDGTQVPTREIEMIVRRAPTVRLYAMMLWIVNWMLTHVTIGFVVLAIKSGDIKRVGLHSLYAFAIVLAIPQIRNAMPDAPDLDELTYTADIIGFFPQTIFSGVDAILLLVVIASRELKEMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7S7</accession>
    <name>W4K7S7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_51829</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545854.1">
        <property type="nucleotide sequence ID" value="XM_009547559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7S7"/>
    <dbReference type="STRING" id="747525.W4K7S7"/>
    <dbReference type="GeneID" id="20678193"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_51829"/>
    <dbReference type="eggNOG" id="KOG1257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011405_5_2_1"/>
    <dbReference type="InParanoid" id="W4K7S7"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000182">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF32">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="10">
        <location>
            <begin position="52"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="9">
        <location>
            <begin position="243"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW81794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="538" mass="60037" checksum="839AE4E598C5FC46" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4K865</accession>
    <name>W4K865_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HRDC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_318347</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the exosome component 10/RRP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546572.1">
        <property type="nucleotide sequence ID" value="XM_009548277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K865"/>
    <dbReference type="FunCoup" id="W4K865">
        <property type="interactions" value="764"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K865"/>
    <dbReference type="GeneID" id="20670500"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_318347"/>
    <dbReference type="eggNOG" id="KOG2206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010129_3_0_1"/>
    <dbReference type="InParanoid" id="W4K865"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071044">
        <property type="term" value="P:histone mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071040">
        <property type="term" value="P:nuclear polyadenylation-dependent antisense transcript catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06147">
        <property type="entry name" value="Rrp6p_like_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000059">
        <property type="entry name" value="Exosome complex exonuclease Rrp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.80:FF:000001">
        <property type="entry name" value="Putative exosome component 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012588">
        <property type="entry name" value="Exosome-assoc_fac_Rrp6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049559">
        <property type="entry name" value="Rrp6p-like_exo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124:SF47">
        <property type="entry name" value="EXOSOME COMPONENT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08066">
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            <begin position="493"/>
            <end position="573"/>
        </location>
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        </source>
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        <source>
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    </evidence>
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        <source>
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        </source>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="847" mass="94576" checksum="40C1757F63778232" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8Q5</accession>
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="22463738"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">TC 32-1</strain>
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    </dbReference>
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    </dbReference>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
    </protein>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
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                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ETW81914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009548210.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009548250.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="20674739"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_156419"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_434304"/>
    <dbReference type="eggNOG" id="ENOG502QPR9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005049_5_0_1"/>
    <dbReference type="OrthoDB" id="3162439at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="5"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW81914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW81955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="486" mass="54135" checksum="5873025A36C70524" modified="2014-03-19" version="1">MRPPRTLVLCFDGTSNEYDANNTNVVKLFSLLKKDNIDQQMCYYQAGVGTYFQPGVVSPLFQWGAKILDEAVAWYLPAHVMDGYKFLMQNWNTGDKVCLFGFSRGAYTARALAGMLYKVGLLPRDNEEQVPFAYRLYASSKSTDLTLAAGFKTTFCRDVPIEFVGVWDTVASVGIVMTKSLPFVSTNNAIRTFRHALSLDEHRAKFRPNLYHRPEMTPSGLATVDSSQHPTLSALRMKIRRSWQEKNRKFEEAMGYGDGHDVDTGSNGSGTRSPGWTTDVCEVWFSGCHSDVGGGAVTDATEYALADIPLRWMVREVMLAQCGITFEEAALTRWNIPLTATEAFKKQTSKPSSPAPGAASPVSANGKDSVENGSNGGNGQNGKGMKRADSVSSWVATRELADAVQPMDDELKKQPLWWILEILPTKYSYQDVAGKWITFWSIHLGRGRYTPPQPKFHESVKVRMEDVALKYAPRAIYDKGTETYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9Y7</accession>
    <name>W4K9Y7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_168889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546715.1">
        <property type="nucleotide sequence ID" value="XM_009548420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9Y7"/>
    <dbReference type="GeneID" id="20668189"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_168889"/>
    <dbReference type="HOGENOM" id="CLU_047592_2_1_1"/>
    <dbReference type="InParanoid" id="W4K9Y7"/>
    <dbReference type="OrthoDB" id="2367075at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="23311" checksum="67602D6AE5A5A3F6" modified="2014-03-19" version="1">MFSMPQGETVQEGSSNSIPIILPTDITVFDFKNFLKAKRAQLVGESASLTGEEWLSVLKLSDLWELPGLRTKAINAVESHIHNLSTVDMILLAKKYCVSKWLMRGYVALAKRTDVITPDESVRLGVYTSCRLAEVRDKSWKYVCHYGRLSNSYYARDYRGCFDFVEEVRRVFRDELMEDEEYRAVHLKQRHSSTSCHRLSQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KA13</accession>
    <name>W4KA13_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_451587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546497.1">
        <property type="nucleotide sequence ID" value="XM_009548202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KA13"/>
    <dbReference type="GeneID" id="20676168"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_451587"/>
    <dbReference type="HOGENOM" id="CLU_125099_0_0_1"/>
    <dbReference type="InParanoid" id="W4KA13"/>
    <dbReference type="OrthoDB" id="2910007at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845319" evidence="1">
        <location>
            <begin position="18"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="173" mass="17983" checksum="E3C195A81DB1CC33" modified="2014-03-19" version="1">MKLSIFSAFALASTALAANTNMDINNFVDSLSESLHIILPNILTLVAAHQANETSIGAQFAQLNTVWDTAGRDLGNVAPSDGSNTTAPTNDDISITFASTLSQTASSLSNLTPTLVANVNSMFSTLDPIVSGTVANFTTALPGGLALVHDLMLDAKQFFQAEGMSLTVTSLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAW1</accession>
    <name>W4KAW1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_426357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545171.1">
        <property type="nucleotide sequence ID" value="XM_009546876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAW1"/>
    <dbReference type="GeneID" id="20674112"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_426357"/>
    <dbReference type="HOGENOM" id="CLU_1360562_0_0_1"/>
    <dbReference type="InParanoid" id="W4KAW1"/>
    <dbReference type="OrthoDB" id="3259206at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="201" mass="21532" checksum="63AFBF555B9C2A56" modified="2014-03-19" version="1">MSATGLDVRHVITGPVIEVSVQSVVYGAHLAHTPSIYVALIIITTYTIMRKGLQSKVNIVMLFISLFMFTMSSGVLALSLASFIETFSGPGQLSEGRFHALSGSAAAMFVVNLILSDSVMVWRASLLWAGSKIVIVIILGFLGATTVSAIMFIGCTGKIFKNNTLCNYASYGGLVLSFTTNFTSMLLIAITAWSVIQQAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCB5</accession>
    <name>W4KCB5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_240182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545661.1">
        <property type="nucleotide sequence ID" value="XM_009547366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCB5"/>
    <dbReference type="STRING" id="747525.W4KCB5"/>
    <dbReference type="GeneID" id="20668847"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_240182"/>
    <dbReference type="eggNOG" id="ENOG502SIER">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046446_0_0_1"/>
    <dbReference type="InParanoid" id="W4KCB5"/>
    <dbReference type="OrthoDB" id="2538017at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="325" mass="35820" checksum="2F03A0CB51888D16" modified="2014-03-19" version="1" fragment="single">NDIVSGEQYRYALTNFRIAHEKVEQQRTQLEEQEKQVALLRARIATLEGTFTLSVPKAGARHGGNSVDDFSIKNAASQLERQINRWATDILRTPPASLNDIRDAAFTDLVGGTEFEHGDDARPMLVQNLLRHLLAETISEAIINCLIVTSSTEANIQLTRIHEHIFARDPTVASVWRRQTFSAAVDACSPEMSRAILEEHMPTLIELLSPADSAPTPVFTAAAAVLESAYEFSRMLHGSPSSAGDTADAFYRSFVPELGSTLYPRQVELVKRCMRSERGELDRVGATIFPGLVKVTRGPMTPGGRSADNMQTVVRRAQVICECAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCK4</accession>
    <name>W4KCK4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_152726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545359.1">
        <property type="nucleotide sequence ID" value="XM_009547064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCK4"/>
    <dbReference type="STRING" id="747525.W4KCK4"/>
    <dbReference type="GeneID" id="20667420"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_152726"/>
    <dbReference type="eggNOG" id="ENOG502SN45">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_386169_0_0_1"/>
    <dbReference type="InParanoid" id="W4KCK4"/>
    <dbReference type="OrthoDB" id="3256495at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="739" mass="80010" checksum="2DB86E6464197769" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCN7</accession>
    <name>W4KCN7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NCS2</name>
        <name evidence="3" type="synonym">CTU2</name>
        <name evidence="4" type="ORF">HETIRDRAFT_417100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTU2/NCS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545389.1">
        <property type="nucleotide sequence ID" value="XM_009547094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCN7"/>
    <dbReference type="STRING" id="747525.W4KCN7"/>
    <dbReference type="GeneID" id="20673383"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_417100"/>
    <dbReference type="eggNOG" id="KOG2594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024534_4_0_1"/>
    <dbReference type="InParanoid" id="W4KCN7"/>
    <dbReference type="OrthoDB" id="25129at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03054">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10288">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW83105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="510" mass="56212" checksum="999B29E9D2845A47" modified="2014-03-19" version="1">MSCGNPNEASGEALMPRKPKFDNLRVCVKCRTSGGNIVIRHAVYCKECFTPLMTTKFRRALEPHINYLPDGPRRSALKPSGDLLVGFSGGLGSTVLLDLVHRIYIAKRRTENGSGGKAHPKTTRVWKNVRVCYVEICDAFPGMRDRTAEIEAAVGRYEGFEFIPSRIQDAFDPCWWETVSGVSSKSPPPWAVDLSNEELFLSPSPSESTPLASLHAYLQSLPTTTAITATISTFIRLLLLYTARANASSHLLLGTSLTSLSISLISSIAQGGGFVIPQEEQEEWVPFSEEHSNNSASNGQWKGEVRIVRPLREIGMKECAAWAWWNDLNVIGKKSFTSSRQTIAGLTKDFIVGLEKDYPSTVSTIARTCGKLAPKDDADSLCVLCERPAQKMAHEWKSRISIRSSSDQKSIQTDSPASLTSRLCYSCHTTLTSRSSRSAVPLKRCEASGPALPVHLPVWINSHLVTEPSSLGVGMTVVPEHTAQESELWKRQRMDNEAMRVAIGEFLLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCP8</accession>
    <name>W4KCP8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_155096</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543337.1">
        <property type="nucleotide sequence ID" value="XM_009545042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCP8"/>
    <dbReference type="FunCoup" id="W4KCP8">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KCP8"/>
    <dbReference type="GeneID" id="20667546"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_155096"/>
    <dbReference type="eggNOG" id="ENOG502RAFH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007858_0_0_1"/>
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    <dbReference type="OrthoDB" id="73680at2759"/>
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    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF270">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="99"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="648"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="818"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1235"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="660"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="717"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="735"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="755"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="892"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="927"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW83803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1277" mass="142111" checksum="B1E6E46AE304E5A6" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDP2</accession>
    <name>W4KDP2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_242280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009547388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDP2"/>
    <dbReference type="STRING" id="747525.W4KDP2"/>
    <dbReference type="GeneID" id="20668923"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_242280"/>
    <dbReference type="eggNOG" id="KOG0585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="InParanoid" id="W4KDP2"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF152">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW83435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="203" mass="23111" checksum="4596DC50FB0D52AD" modified="2014-03-19" version="1" fragment="single">IRKEIAVMKRCRHPHVVRLIEVIDDKLYKKIYMIMEYLGGGEIKWRDQDNNPILRVEQARRICRDVILGLEYLHKQDIIHRDIKPANLMWTSDRRSVKITDFGVAHLSGRDPEEILLFDKAELAKTAGTPAFLAPEVVWEFGNVPASSTPASPATPPENGSVPSITKSIDLWAFGVTLYSLLFGRTPFVAEGNHEFMLYHVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4KE10</accession>
    <name>W4KE10_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_439015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543807.1">
        <property type="nucleotide sequence ID" value="XM_009545512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KE10"/>
    <dbReference type="STRING" id="747525.W4KE10"/>
    <dbReference type="GeneID" id="20675095"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_439015"/>
    <dbReference type="eggNOG" id="ENOG502S0CB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085801_0_0_1"/>
    <dbReference type="InParanoid" id="W4KE10"/>
    <dbReference type="OrthoDB" id="37297at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875:SF2">
        <property type="entry name" value="ACR183CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875">
        <property type="entry name" value="OS09G0542200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="1">
        <location>
            <begin position="11"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="205" mass="22593" checksum="A2CDF24D81AABED5" modified="2014-03-19" version="1">MALQPSLRPLVVAGRYDAPHTLDIFLDYVCPFSAKLSLAIDSVLKPLLDAGGKYDGKVKVIIRPQVQPWHASSTFTHEAGLAIARVAPENFWQFSLLLFKQQEDYFDIPTSTLTPLQIREKLAALAAQVIPASKVGEFNDLLRLKSSPNGGVAVTDDLKYTIKFSRQNGVHGSPTVLWDGLVANEISSSWGEKEWSEFLAQKIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4KER5</accession>
    <name>W4KER5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Topoisomerase I damage affected protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_123936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544010.1">
        <property type="nucleotide sequence ID" value="XM_009545715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KER5"/>
    <dbReference type="STRING" id="747525.W4KER5"/>
    <dbReference type="GeneID" id="20666849"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_123936"/>
    <dbReference type="eggNOG" id="ENOG502SE9C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097204_5_0_1"/>
    <dbReference type="InParanoid" id="W4KER5"/>
    <dbReference type="OrthoDB" id="10260741at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21449">
        <property type="entry name" value="DLC-like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF7">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE PROTEIN 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="14921" checksum="5DC6DCBB55E102CA" modified="2014-03-19" version="1">MASATLPGMRSPMTPRSNAPSPRPKFDSDLLKAYVKKLLSTTLQGASWPEARDRDRVRAWMKEIGERVKERMIEIEPRGFKYIVLTQINENLGQGGRADMICHWEDSDTVVQEVLVNDSLICICIAFAVRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4KES0</accession>
    <name>W4KES0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_170259</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543541.1">
        <property type="nucleotide sequence ID" value="XM_009545246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KES0"/>
    <dbReference type="STRING" id="747525.W4KES0"/>
    <dbReference type="GeneID" id="20668272"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_170259"/>
    <dbReference type="eggNOG" id="KOG2175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_708001_0_0_1"/>
    <dbReference type="InParanoid" id="W4KES0"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central" evidence="4">
        <location>
            <begin position="2"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="109"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="205"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW83795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="389" mass="41621" checksum="5D3D0EC0E5120BA6" modified="2014-03-19" version="1">MAHLLKQDVFKAILELALQESDRDTLVNSSCQEFFDHMRKDGAQENMKEAIDDIMTRQEALVRQLAQSRFAKTCFEHFILRWEMNTAPEPPKEEKLPAPHLSQPFELRRQEAEEESYFNTDDDNDDDDGSPPLLSTPLLTRHQFAGQKRKRQRVPGLPMRPLRPPSIHLPRAPLIGSLVDYDEDEDDRELAVDLNLDLDRRLAPLGPHDGDAEADTGAGAVHPPVAPVPTPDAPPTPRLSHRLIASAKRGRTPDADDAGGGGNDGEQPDTGGGGGFIPLSPRPEKRRRGDDDGDDMGLERLLSKVKRPSLTPVAPAKEGAAPTAATPPPAGAGRIGVTGGVKPGAEDGGPKKIKLKFGVAGLAVASSAPSAAAAAAARSEPGVKDGDTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFN9</accession>
    <name>W4KFN9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_314398</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BCD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543594.1">
        <property type="nucleotide sequence ID" value="XM_009545299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFN9"/>
    <dbReference type="FunCoup" id="W4KFN9">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KFN9"/>
    <dbReference type="GeneID" id="20670119"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_314398"/>
    <dbReference type="eggNOG" id="KOG2858">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025524_1_0_1"/>
    <dbReference type="InParanoid" id="W4KFN9"/>
    <dbReference type="OrthoDB" id="272357at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF3">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="9">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="98"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="367"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="372"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="425"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW83856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="445" mass="49397" checksum="70A7E47DD9DC1548" modified="2014-03-19" version="1">MTDPSPSDSSFASTSGPQCSICEKNAAIYTCPRCATRTCSLPCSNSHKSQTRCSGLRDKARYVPMNQYSLGTMMDDFVYLEEMGRKVGDWGKEIVRGGFGPGQSLGKSRDGVMGTRGGSQGRGRGRGRGGVQRTKRDVLKMQLELRDVDVDMLPAGMAKRMVNQSTWDFKNRTALLTIEFKFYPPQDPAANPSHPQDPPYTLLTHRNNFDLPLISLIQSQIKERLKGKRENPFPHWLKPLILPDQEVPDSFTPPQFLMPTALDPLTTPLSIKQFAKIGYHRLEATQKLSTLLRHKHFVEFPVIEIWEEGAFRGLVVDERGGMQREGDERVVKRRKLDIGASKKAMSGLLSGYGSDEEREEDTPITVLGDYAGSEDDGTLDDEDEGDALGAEELEGDSDEDKEIGPVDYAALLDILRQNGVHEAGGDDEVDWGEDEDEVRASARNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFR6</accession>
    <name>W4KFR6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peroxisome membrane anchor protein Pex14p N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_472617</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543859.1">
        <property type="nucleotide sequence ID" value="XM_009545564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFR6"/>
    <dbReference type="STRING" id="747525.W4KFR6"/>
    <dbReference type="GeneID" id="20677468"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_472617"/>
    <dbReference type="eggNOG" id="ENOG502SM68">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058471_0_0_1"/>
    <dbReference type="InParanoid" id="W4KFR6"/>
    <dbReference type="OrthoDB" id="441517at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006785">
        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="3">
        <location>
            <begin position="37"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW84155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="384" mass="42690" checksum="7604EDA3E19A2749" modified="2014-03-19" version="1">MDDQDKGATSVASSSKLPPSPPHTHQQAGPQHSDVSERSDLLERARVFLASPQVRHEDVSAKRRFLVDKGLSETEIITLLQELPSQVPLVPPRTYPLPPPSNLPNLLAGLFRILTWVAGGSTVLLLVYYRFLLPRLTKSSLARHSIIVHQKDLLSKLTTSISHFKNEQKQSFEVLPQLALDREEPRYKQCGGLDDLVSAGDDRRDIPVFTLLRCALADFAKQDLHPSWEELSVAITTKFPWFESDSSCQHQACETLLKHPLFHDVEDSSSNPARWSYQPQAPVLDPASVDPLDSLNASLASALPTSTSNRYQHTLQSLIDFTGYLTTKTYSLSPPALPRVSGFGVTLSPEEDEVRREIRALKGLVLNRKSFLPPRQASVPLNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFS9</accession>
    <name>W4KFS9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD/PDEase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_313664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544344.1">
        <property type="nucleotide sequence ID" value="XM_009546049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFS9"/>
    <dbReference type="STRING" id="747525.W4KFS9"/>
    <dbReference type="GeneID" id="20670050"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_313664"/>
    <dbReference type="eggNOG" id="KOG2681">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026821_1_3_1"/>
    <dbReference type="InParanoid" id="W4KFS9"/>
    <dbReference type="OrthoDB" id="9991235at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050135">
        <property type="entry name" value="dGTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF4">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="1">
        <location>
            <begin position="62"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="507" mass="57076" checksum="A6A0421F80858298" modified="2014-03-19" version="1" fragment="single">MADMDDECDSASAMSTTRRFKDPIHDYIPLAPEVCAVVDTKHFQRLRNIKQLGTSYYVWPGASHNRFEHCLGVAHLARLMTEHLQKSQPELDITDRDVRCVMLAGLCHDLGHGPWSHVWDSMFIPRALSVPAPARKKWKHEDASEMMFDDMIRQYDLGISEQDATFIKALIAGDKTRCADTLEKPFLFEIVANKRNGIDVDKFDYIARDSNAIGERGNLSLSRLIDSSRVVDNEICFDIKDANQVYELCYTRFSLHKRIYHHKTGTYPTKAIEFMIIDALLAADPYMKIAECIEQPSEYISLTDDIMPFIERTKDPELAESRAIFARIRERDLYKCVDYKVFEWGMHDLLQAEVTAAAIVREAKRLDAAAAAARAAQSKDIAALQARDVIVSLSQMHHGMGEDNPLDSVKFYSKRNLDRSQHAGRGDLSILMPASFGEVLLRVYTKDTRYFGIVQAGYRSIMQQLRDRAAAAAAALVADSVPPSPMIAATELELPLTPSTPPPPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFW5</accession>
    <name>W4KFW5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_381222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544568.1">
        <property type="nucleotide sequence ID" value="XM_009546273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGH5"/>
    <dbReference type="GeneID" id="20672714"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_408757"/>
    <dbReference type="HOGENOM" id="CLU_2831477_0_0_1"/>
    <dbReference type="InParanoid" id="W4KGH5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="66" mass="7333" checksum="36445CF47915F393" modified="2014-03-19" version="1">MHTHHPLPSPSSSHPPGPMHTRPLGHNNPFDCSLTSPCRRRTRVSPLRTACRNRHATRASLALPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGQ5</accession>
    <name>W4KGQ5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 18">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="6 18">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 18">Alpha-IPM isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 18">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HETIRDRAFT_62958</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 18">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 18">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6 18"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543282.1">
        <property type="nucleotide sequence ID" value="XM_009544987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGQ5"/>
    <dbReference type="FunCoup" id="W4KGQ5">
        <property type="interactions" value="132"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KGQ5"/>
    <dbReference type="GeneID" id="20678624"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_62958"/>
    <dbReference type="eggNOG" id="KOG0454">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006714_1_2_1"/>
    <dbReference type="InParanoid" id="W4KGQ5"/>
    <dbReference type="OrthoDB" id="2279155at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000007">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000003">
        <property type="entry name" value="3-isopropylmalate dehydratase small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012235">
        <property type="entry name" value="3-IsopropMal_deHydtase_ssu/lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002458">
        <property type="entry name" value="PRK01641.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004016">
        <property type="entry name" value="PRK05478.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009116">
        <property type="entry name" value="PRK12466.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF9">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001418">
        <property type="entry name" value="ACN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 18" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="19">
        <location>
            <begin position="13"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="20">
        <location>
            <begin position="533"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR001418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ETW84236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="755" mass="82218" checksum="49B6E86C6DE2D4D4" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4KH83</accession>
    <name>W4KH83_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_311929</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31307"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19521"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132521"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="EC" id="2.4.1.265"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:31308"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544076.1">
        <property type="nucleotide sequence ID" value="XM_009545781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KH83"/>
    <dbReference type="FunCoup" id="W4KH83">
        <property type="interactions" value="406"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KH83"/>
    <dbReference type="GeneID" id="20669910"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_311929"/>
    <dbReference type="eggNOG" id="KOG2576">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022045_1_1_1"/>
    <dbReference type="InParanoid" id="W4KH83"/>
    <dbReference type="OrthoDB" id="1689333at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042283">
        <property type="term" value="F:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF2">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE GLC1MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW84401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="545" mass="61889" checksum="7B6C26A77E213272" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHH7</accession>
    <name>W4KHH7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_424632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542151.1">
        <property type="nucleotide sequence ID" value="XM_009543856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHH7"/>
    <dbReference type="GeneID" id="20673992"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_424632"/>
    <dbReference type="HOGENOM" id="CLU_711852_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHH7"/>
    <dbReference type="OrthoDB" id="3266451at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="11"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="388" mass="43903" checksum="80C245BD69423E41" modified="2014-03-19" version="1">MRGAITQSPRRLPPEILDNIYSFRVVVDLPRKQNLGWIKVSHVCSYWRDVALENTNLWTKINLDLGREWVSEMSMSAKQASLVFKSSCMESSVQLITPHLPRARVIILSGIVDPFHNLQPIDAPAQIVEHVELSVRAEDNCITELPENLFANHAPLLRTAYFSGLAIPWSSTVFHNLTSLKVYGNSAENSSMPPYDTFFDALSEMCYLETLLIYDALPPLSASTSDPLWDLAMFRSVVGRAQSLKRISLSKSILRPFCIAMKKDMDTTAPEQTPAESYSEHIPFPSLKVIHLHPLRVSNVSKLDRTVGFLTRVLRKRTTLRAPIRQIDIIQPDLPEKWMEELRAVVPNVTWRGGRAADRFKFKSELFDAISQRGTKCQSVGAENRDVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KI29</accession>
    <name>W4KI29_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_108666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW84975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541872.1">
        <property type="nucleotide sequence ID" value="XM_009543577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KI29"/>
    <dbReference type="GeneID" id="20666368"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_108666"/>
    <dbReference type="HOGENOM" id="CLU_1906979_0_0_1"/>
    <dbReference type="InParanoid" id="W4KI29"/>
    <dbReference type="OrthoDB" id="5588096at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="133" mass="14388" checksum="46C310E6B834C527" modified="2014-03-19" version="1">MTTRITTPRVITEIGRAVSIRRAIKQELGQYTPAPASASNEFSPTLYSVEEAKPAAPVQRASSSSASNRRVDRPEEDHYPLQPNLLRQQPPYSAESPSRRLPLSGRSSGDGRFRKASSECSSSAGCSPPPTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KI45</accession>
    <name>W4KI45_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_448481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542224.1">
        <property type="nucleotide sequence ID" value="XM_009543929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KI45"/>
    <dbReference type="GeneID" id="20675863"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_448481"/>
    <dbReference type="HOGENOM" id="CLU_774010_0_0_1"/>
    <dbReference type="InParanoid" id="W4KI45"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="358" mass="39545" checksum="DE8DAEA9A69B0C59" modified="2014-03-19" version="1">MSVAGILLAAKIASVATSLIISGASTALMARKKRNVAFPLELLPKVAGLVVGEFLFDLVLLPELAKDWDAIMTLLNASKEFRRNTLDILCALYGLHAAGAGRTQAVVKYKETKPIFRHLSSVAHDTPAAFGKLSAELFRRPSAPVVKLWLSVLGCIAEENSFFKSSQNSFIAIITGTRVKQMRKEYNLVPKEMRGQVLGLFMRHVNMRHAAWLRLKAVHTAIDRVSLFCKNFSKAGLKSKWENLPFGLGQRIKTRTDLTKRSSAVRALVAHITGIPEHDLPELKLKEVATACILTGLREVLSTLTALESSSGDADLGAKNCQYARNYLAIHFTENEREVYMPGQVKFWDKVLKLVGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIU2</accession>
    <name>W4KIU2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_432307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542467.1">
        <property type="nucleotide sequence ID" value="XM_009544172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIU2"/>
    <dbReference type="GeneID" id="20674605"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_432307"/>
    <dbReference type="HOGENOM" id="CLU_1927889_0_0_1"/>
    <dbReference type="InParanoid" id="W4KIU2"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="131" mass="14633" checksum="3BBFB10374DBF719" modified="2014-03-19" version="1">MERSRRSYFIKSCERARHASAVHLGGDWEGSLDWGGERRCKVRARGPPRVEKTARTRATPSDFQPPRHVFPHRFVSRLSALRHLSDISASPLLRPLSPLSPLCRPLPPRSEALLFIPLSGIDACDTCSPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJ13</accession>
    <name>W4KJ13_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Geranylgeranyl transferase type-2 subunit alpha</fullName>
            <ecNumber evidence="2 9">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Geranylgeranyl transferase type II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_470846</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="2 9"/>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542541.1">
        <property type="nucleotide sequence ID" value="XM_009544246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJ13"/>
    <dbReference type="FunCoup" id="W4KJ13">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KJ13"/>
    <dbReference type="GeneID" id="20677364"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_470846"/>
    <dbReference type="eggNOG" id="KOG0529">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031996_1_0_1"/>
    <dbReference type="InParanoid" id="W4KJ13"/>
    <dbReference type="OrthoDB" id="1658at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.120:FF:000035">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF2">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW85709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="363" mass="42231" checksum="CC7613651CE967AD" modified="2014-03-19" version="1">MHGVRRVRESLKVQEEKKQKEKAKLAAYLALTDKVLSKKKSNDWSGEAFELTSRLLNINPEFYTIWNYRRNILTRGIFPSSSPAEINGILSNDLDMTTTALKAHPKVYWIWNHRRWCLENIPDGGDNNDEHGWRKASWERELFIVEKMLDADARNFLAWGYRRYVLASMPVRRPEIVELASTTRKIEANFSNFSAWHQRTKVLASLWDSGKLDKHSSLQQEFDLVQNAMYTDPNDQSVWLYHRWLIGTGRLVPCCPSHHTRASFDTLIVNVSTCVWFLRHHYTMASLGCMDTLVYYKQLLLRKHPTHIGSLEAKALVQQCIDLLQQLESVDPSRRQRYRALGQFHLLLSTSDPALTNDYQPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJ44</accession>
    <name>W4KJ44_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_379821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542564.1">
        <property type="nucleotide sequence ID" value="XM_009544269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJ44"/>
    <dbReference type="GeneID" id="20671990"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_379821"/>
    <dbReference type="eggNOG" id="ENOG502STK9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113386_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJ44"/>
    <dbReference type="OrthoDB" id="3242721at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="177" mass="19536" checksum="547541630758A8AF" modified="2014-03-19" version="1">MPNALVPSSTLSSEALEEFLSILRPTLFRPQSPTLLTRKIPTLAFSHERAHSLSSRSLERLENVPILSSAFRNETRTPFKQTSPRLRTPRQEDEEKDNVTELVPIRPVGSGPLASPISRIHTRNPFQRHASYETFKSTGNLFQVGMTPPPQTPAPAPSSPAMIPLPPPTPSEADPLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJ80</accession>
    <name>W4KJ80_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_311201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542230.1">
        <property type="nucleotide sequence ID" value="XM_009543935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJ80"/>
    <dbReference type="GeneID" id="20669849"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_311201"/>
    <dbReference type="HOGENOM" id="CLU_172948_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJ80"/>
    <dbReference type="OrthoDB" id="2748701at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8536" checksum="A7490836B480B27B" modified="2014-03-19" version="1" fragment="single">MDRCPMEVWKLIFEFACTDDGTTGCSLALAARWTNFISASVRLQSIGVKTAEQLPRVADMLESLPQDRRHTHILSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJF9</accession>
    <name>W4KJF9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">DEAD-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HETIRDRAFT_43950</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541795.1">
        <property type="nucleotide sequence ID" value="XM_009543500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJF9"/>
    <dbReference type="FunCoup" id="W4KJF9">
        <property type="interactions" value="781"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KJF9"/>
    <dbReference type="GeneID" id="20675155"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_43950"/>
    <dbReference type="eggNOG" id="KOG0330">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_1_1"/>
    <dbReference type="InParanoid" id="W4KJF9"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17954">
        <property type="entry name" value="DEADc_DDX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044765">
        <property type="entry name" value="DDX47/Rrp3_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF20">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="46"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="240"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="402"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETW85993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="49677" checksum="45CCB97A6C2F9252" modified="2014-03-19" version="1">MPSAEEASTSTSSTPTFKSLGLIDPLLEALNQLEYKNPTDIQVESLPHALEGRDIIGVASTGSGKTAAFALPILQKLWEEPKGLFACVLAPTRELAYQISQQFEALGSAIGVRCAVIVGGMDMVSQSIALAKRPHVIVATPGRLIDHLENTKGFSLRGLRYLVLDEADRLLDMDFGPVIDKILKVIPKERTTYLFSATMTTKVAKLQRASLSNPVRVEVSSKYSTVDTLLQYYLLVPLSQKDVHLIYLANSMAQNSIMIFTRTVHDAQRRMSIILRTLGFPAIPLHGQLSQSQRLGALGKFKSGGRNILVATDVASRGLDIPSVDVVINFDIPTHSKDYIHRVGRTARAGRSGKSITLVTQYDVELVQRIEEVVGKKMELWPTDKDEVALLRERVDEAGRLAANELKDQAVKGGRGRKRRREEGGDRDNRDRDDDVVEAGMPSRQKKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJH0</accession>
    <name>W4KJH0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_309422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542084.1">
        <property type="nucleotide sequence ID" value="XM_009543789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJH0"/>
    <dbReference type="GeneID" id="20669676"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_309422"/>
    <dbReference type="HOGENOM" id="CLU_2606320_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJH0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="79" mass="9044" checksum="807A25A437EF7D8E" modified="2014-03-19" version="1">MRLDDLLGEKTARVGRHGTARRVRITWAQCRRRIRRGSEMRRVGISRQCGRADSRRAYVWCGSLSVSKVASVLHAVLHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJH7</accession>
    <name>W4KJH7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lipid transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_60299</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541836.1">
        <property type="nucleotide sequence ID" value="XM_009543541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJH7"/>
    <dbReference type="FunCoup" id="W4KJH7">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KJH7"/>
    <dbReference type="GeneID" id="20678505"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_60299"/>
    <dbReference type="eggNOG" id="KOG3030">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021458_6_0_1"/>
    <dbReference type="InParanoid" id="W4KJH7"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000017">
        <property type="entry name" value="Diacylglycerol pyrophosphate phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF35">
        <property type="entry name" value="RE23632P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="105"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="290"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW86013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="342" mass="37745" checksum="3008D8B91A799FD4" modified="2014-03-19" version="1">MFGSGDTGRPRRKTDNVRRRKLLLSYAPDWVVTIALAAAFFALDKVTGFKREFSVTDTSLRHPYAVHERVPNLALYMIAIVAPIVLQWVANVFTIRSWWDAHNSTLGVILGLSLTGAITQFAKITVGRPRPDLISRCNPVEGTVDPTFGLSSAAICNQSSTYILEDGFRSFPSGHASLSFAGLGFLSFYLAGKMHLFDRRGHAAKAWIALTPLAGASLVAISRTMDYRHHWQDVLTGSILGLVTTYFAYRQYYPSLASEHSHRPYSPRIKRDEATLPMHRPTPSADVMYSGASGHGASQYHDGSEEEVELVDGTVRRGGPGPLEDVWKDGDERRKSPHDGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKN7</accession>
    <name>W4KKN7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_457421</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542469.1">
        <property type="nucleotide sequence ID" value="XM_009544174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKN7"/>
    <dbReference type="FunCoup" id="W4KKN7">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KKN7"/>
    <dbReference type="GeneID" id="20676830"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_457421"/>
    <dbReference type="eggNOG" id="KOG1973">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031900_8_1_1"/>
    <dbReference type="InParanoid" id="W4KKN7"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
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        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
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    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
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        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
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    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF42">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="399"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="120"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="165"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="317"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW85631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="453" mass="49708" checksum="FA6B5894E4ECD882" modified="2014-03-19" version="1">MPARKRRRSQAFGRDHSQDAAPGSIASNEDDVRSDDVGETVDSPNGAQHEESVSKEVSKEAELWEAFKEEYHEALEQLPLQLHRHFALMKELDEEATRHAAKVTPVLQQYISVRRSLAGLPARTPDPVKMPLESPESTPLGDGDTTMKDGTEAELNHSEKSAFISRNAPSPHAGARNPFPSKQPDPVGPSTAASLSTQRTPVSAPVLLESQTPFELPRELLSQVARLAEDAVQASLEKVHIAQAAYNSVDRHIRMLDRAIKEQEDALSLDLHPGYHPALLPDLLVPRWTRGPRIESSPLPGFDALDDENMDVDVEDAEVDNGDEESPAFGLTSGDVAADRGRSASKKSKKGKGRKKEKDAAERDTSKATTPAPQPNFKLKIPPSTAVVSGDLPVHPNEPKYCYCDQVSYGHMVACDNAGCKREWFHLSCAGLTEPPKSTKWYCRECTGKRKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKR9</accession>
    <name>W4KKR9_HETIT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_423676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86448.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009542174.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="20673933"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_423676"/>
    <dbReference type="HOGENOM" id="CLU_125566_0_0_1"/>
    <dbReference type="InParanoid" id="W4KKR9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="164" mass="18285" checksum="1A000CDF42B3E3AE" modified="2014-03-19" version="1">MSSDGSLYLSSVDDTLVDERTLSLPSYLRSPTVSEVGDFEARYIREETRMLSMLEQEDQMEEVERRYQARVDANAAEEAAAAQTPGSPVIDISTSSSSSPSPPPLIREANEGIIFPDRETYLTTPIVYMMGLIEGTPNTEFVSGPTRPEIQRTLEILEEERSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKW4</accession>
    <name>W4KKW4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_28547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540268.1">
        <property type="nucleotide sequence ID" value="XM_009541973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKW4"/>
    <dbReference type="STRING" id="747525.W4KKW4"/>
    <dbReference type="GeneID" id="20669290"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_28547"/>
    <dbReference type="HOGENOM" id="CLU_154299_1_0_1"/>
    <dbReference type="InParanoid" id="W4KKW4"/>
    <dbReference type="OrthoDB" id="2669721at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="96" mass="10830" checksum="54A84431F77F9CAD" modified="2014-03-19" version="1" fragment="single">QIIFQLHIPYDQLLKASILLSDFVYDFEVLYVQHKTSCLHFVPQCMHAITHTPSTTFRIGPLGCSLQFPMEQTIGDLGAETKQLSNPFANLAQHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKX7</accession>
    <name>W4KKX7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_306326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540496.1">
        <property type="nucleotide sequence ID" value="XM_009542201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKX7"/>
    <dbReference type="GeneID" id="20669399"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_306326"/>
    <dbReference type="HOGENOM" id="CLU_2654782_0_0_1"/>
    <dbReference type="InParanoid" id="W4KKX7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="91" mass="9726" checksum="0C43E791F4581911" modified="2014-03-19" version="1">MLIGSSLSKGSGRIADSSTNTGNTDVDSQSADCVSRSIDSGVKRPGLKRSRDFTPSRVSTPAKRLREAESTHMLSAQTLIDSLLYLLISLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KL07</accession>
    <name>W4KL07_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_99013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540544.1">
        <property type="nucleotide sequence ID" value="XM_009542249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KL07"/>
    <dbReference type="GeneID" id="20678881"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_99013"/>
    <dbReference type="HOGENOM" id="CLU_1695701_0_0_1"/>
    <dbReference type="InParanoid" id="W4KL07"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="168" mass="19310" checksum="4A12BACB4F3098DD" modified="2014-03-19" version="1">MLATGAGRASAAIGAQNGILVMITFCRALTAVYTDTIITNIKRPHKERHTTSGDIDPHRESVTAHTLEQDLGQEYPPGTRRINNQLRHNNRPIRHEGDFWVYEDNNRYAPPNYDNCSYRNGRYYFTLEDGTEKEDIWNETEAQWELAPQYREPAPVIPEDSEQEETTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLQ7</accession>
    <name>W4KLQ7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_99205</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540751.1">
        <property type="nucleotide sequence ID" value="XM_009542456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLQ7"/>
    <dbReference type="GeneID" id="20678896"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_99205"/>
    <dbReference type="eggNOG" id="ENOG502QU6M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021993_0_0_1"/>
    <dbReference type="InParanoid" id="W4KLQ7"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="111"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW86762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="496" mass="52649" checksum="56E5B97E2B6CAD99" modified="2014-03-19" version="1">MSVAVESPVEFSSAIEPQSERPGLQERLSRPQTERHDSDFTAVGPATPAGDKLDSATDEARIANGAAEQVQGVVYVVNVEAAYPPPIVSSALAITPVVELLSESRGLRRFRMFASFVTLFLAGWNGGATGALIPSIERAFGIGYARVAILFVSTFMGYVAAAAGGGVLSRKIGFGGALLAAVAIELIGNVINASQQASFGLMCFGFWIIGIAFATQLGLCNAYFTLLKKPLLYTGFLHGMFGLGAFASPLVATAMVTRGIPYHFFYLTNVGMNVPVFALVWFAFRNLDSLSSNPADTLTLQGSATMRDTLKSRTVWTLAIFLMLYIGAEDSIGGWIVSYVLEVRKGTPEGASWVASSFYLGIAIGRIVLPTLSILLGERRAVFIYIFLAIVLEAVAWAVPVLASTALATALVGLAISTFYAAAITTGGRLLPRPMHADAFLLISSVGQSGSALFPLVVGLVSSKKGIWVVEPIILALLGGQGVFWYLVPKVQRRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4KM74</accession>
    <name>W4KM74_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_165994</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540498.1">
        <property type="nucleotide sequence ID" value="XM_009542203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KM74"/>
    <dbReference type="GeneID" id="20668029"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_165994"/>
    <dbReference type="eggNOG" id="ENOG502RW2M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048769_0_0_1"/>
    <dbReference type="InParanoid" id="W4KM74"/>
    <dbReference type="OrthoDB" id="3049938at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="270"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW86480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="325" mass="36871" checksum="0B79260861D54086" modified="2014-03-19" version="1">MSDRGNKPKDFDGTRSKYREWIYECHMYILANPTKYDTDKDKTLMVLSYMREGTASLFAQKYYFDRELQEYKPTETRKAWGTFKDFLKELAAAFKDESLEQKARQKLFTMRMGKRSADEFVTDYLMTAGESGFDLESTIDYFRRAIHPEILKQIYRLPDMPTTMDDWVKYTRRFDNQWRELQSIKSSVPSATIRSSNPFRYNSSNAPSSMNNSVVPIAVDSVRTTLTDEERNRLRMEGGCFYCRQKGHMANQCPVRGSSRLYEGSARYVQQSSGTMGNRSAQTGGRMGGGGSGYGRAFSAGTSGSAQGGAATQGRSVATTNPFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KN11</accession>
    <name>W4KN11_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_447771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541132.1">
        <property type="nucleotide sequence ID" value="XM_009542837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KN11"/>
    <dbReference type="GeneID" id="20675804"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_447771"/>
    <dbReference type="HOGENOM" id="CLU_1185138_0_0_1"/>
    <dbReference type="InParanoid" id="W4KN11"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="234" mass="24735" checksum="B46A7A5BAAE9C528" modified="2014-03-19" version="1">MGGKGSEGHAVTGGGREGEKGEGRREQGGSRREGAEGSSRRATLAWRAEQQSTPSVQNRRSGSSVSVSASQPTLPTPSLLAAALVLAPALALAPVAPTADSAADAPRPRPPPPTAVLDDARTGLARRSHPRDVTPTQIHLRSITPLFGPRQDPVTPLFSSPPVLSFPSFRSFRAPPTHTHAHVRSPIVPPPSARYACPPHPPSLHVHLARPSTPTRALSIQDLDLPYPRLLHHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNA8</accession>
    <name>W4KNA8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_99020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540552.1">
        <property type="nucleotide sequence ID" value="XM_009542257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNA8"/>
    <dbReference type="STRING" id="747525.W4KNA8"/>
    <dbReference type="GeneID" id="20678882"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_99020"/>
    <dbReference type="HOGENOM" id="CLU_050560_0_0_1"/>
    <dbReference type="InParanoid" id="W4KNA8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="402" mass="44098" checksum="8C35D3AB9F69AE91" modified="2014-03-19" version="1">MLLHEDHDALSPSRNSSPDVVLMVSNPDVGWVDRGTSPHRSNAGRVDRGTSPHHPEPAIVTLTPNLNNFSDDDTEDYAKFKERERTHQPSPRGSSRDAPRHENPNDRNLPGANKLPVGVPPPTRVMTNTRAAGPSGLQARTTAQPPSHGETEPIPVIQGATPPSVPISGQVPSSMGRPTPGTNPHSGELERHTDVLIQCNTISADNPEMKIATYLDDWLVPVSRSGGSPSKLILTRPPGTNTMMDDHELSSSIPMSSPSMSTESSFQLSSSPENWEMSNQAEPTLSALSLGTYHVWENVPQLYQIQEEYEIFPYPMGVPMRRNRPSIKKMKEEGVEEARQPSAVEQLLAGVFDTGLECLLIVLDFVQTRDRITEVATELTVLIWRLEEIALGLDLSSMHGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNX7</accession>
    <name>W4KNX7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rhomboid-type serine protease</fullName>
            <ecNumber evidence="10">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">sps54</name>
        <name evidence="12" type="ORF">HETIRDRAFT_307583</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="10"/>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541305.1">
        <property type="nucleotide sequence ID" value="XM_009543010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNX7"/>
    <dbReference type="STRING" id="747525.W4KNX7"/>
    <dbReference type="GeneID" id="20669504"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_307583"/>
    <dbReference type="eggNOG" id="KOG2290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022618_1_0_1"/>
    <dbReference type="InParanoid" id="W4KNX7"/>
    <dbReference type="OrthoDB" id="2146116at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="11">
        <location>
            <begin position="163"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW87399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="406" mass="44930" checksum="3647073A2BAB6BD3" modified="2014-03-19" version="1">MYIFATTSDSSVGIEFAEPYDSKRAIPVTEKGSALSRFLENGKYPIEQRIEDKKRGIGRQKYPFVVWALTIAMIGVFIYELVLNSKEQGTPVSFKPTVNVMLGPSSSALINIGARFPPCMKDVTTVPASTNMACMNDTANPPDRICTIEELCGHGGFGDGEPNQWWRFITPIFIHAGFIHIILNMLAQLTAVAQIEREMGSGGFFILYFAAGIFGNVLGGNFSLVGIPSVGASGAIFGAIAVTWVDLFAHWKYHYRPVRRLVFMTIELLIGIAVGYIPYVDNFAHLGGFLMGLLVGTTFYPVISTTKRHRVIMWMFRLTAIPLAVILYVVLIRNFYTSDPYAACSGCRYLSCFPTSSNNHCKGYVSRSFFDSHAHSRVIPFAIVITIELVSSGHALVRHVSNLIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KP92</accession>
    <name>W4KP92_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_308234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540829.1">
        <property type="nucleotide sequence ID" value="XM_009542534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KP92"/>
    <dbReference type="GeneID" id="20669561"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_308234"/>
    <dbReference type="HOGENOM" id="CLU_1046052_0_0_1"/>
    <dbReference type="InParanoid" id="W4KP92"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="266" mass="29357" checksum="947391E52CA215C1" modified="2014-03-19" version="1">MSVFGCLLEHSRSSTKLWCGRMVVAGDGPGLKEKIASVGARPVFGRDTPSSLMVPTPRLGSRSLPREGHSLSLDRPQALIRYNTSRVAQQPLHHHHCVALGSLSHYTDALYFHAAPEPFFTEVGKGRRPCLPRSRLPHHVLSSHPLSACLLLISSLPVPRSFTPSDYFTVSISVFILVPVRFPYPIPPACIDMASGCPLIPHLVVALHIVGQSPFEGEWDERGRCVWLGPSKSLELEGRSVSRSTRKPRARHLPRHHPASMGFLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPH0</accession>
    <name>W4KPH0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Formamidopyrimidine-DNA glycosylase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_154087</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541575.1">
        <property type="nucleotide sequence ID" value="XM_009543280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPH0"/>
    <dbReference type="STRING" id="747525.W4KPH0"/>
    <dbReference type="GeneID" id="20667472"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_154087"/>
    <dbReference type="eggNOG" id="ENOG502QVDB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038423_0_1_1"/>
    <dbReference type="InParanoid" id="W4KPH0"/>
    <dbReference type="OrthoDB" id="444592at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08972">
        <property type="entry name" value="PF_Nei_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000009">
        <property type="entry name" value="Formamidopyrimidine-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="entry name" value="MutM-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="FPG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="H2TH_FPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993:SF9">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="N-terminal domain of MutM-like DNA repair proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formamidopyrimidine-DNA glycosylase catalytic" evidence="11">
        <location>
            <begin position="2"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="287"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW87707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="326" mass="36602" checksum="03FF8087511F35F1" modified="2014-03-19" version="1">MPELPEVERAAALVRTLALNKKIEKVLTSEDALIFSGISHQEFAKELVGRTIANVGRYGKVFYFELDGKGRMPVFHFGMTGTLQVKGEAPTYYKGGLRKVSTEWPPRFMKFILHISSPSSEVVTEIAYSDARRLGRIRLVTSPFNEPPISTMGFDPILSMPGIDGFKKVVIKRSCPIKSLLLNQSFSAGIGNWVADEVLYHSRVHPEQRCNTLSEDQLIALHHQIIEVCRIAVEANADDAKFPQDWLFKHRWSSGELATIKWITVGGRTSAYVAELQHLPNDLTPLPDSDADAVVQTTRRKRKESASKTLRGSKIRESKRVKTSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPK7</accession>
    <name>W4KPK7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_42244</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
            <location evidence="1 6">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540355.1">
        <property type="nucleotide sequence ID" value="XM_009542060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPK7"/>
    <dbReference type="FunCoup" id="W4KPK7">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KPK7"/>
    <dbReference type="GeneID" id="20673814"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_42244"/>
    <dbReference type="eggNOG" id="KOG2065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009597_0_0_1"/>
    <dbReference type="InParanoid" id="W4KPK7"/>
    <dbReference type="OrthoDB" id="1608002at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF27">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="2"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="290"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW86986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="720" mass="80819" checksum="BB5C046BB2B25404" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPS4</accession>
    <name>W4KPS4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_114754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
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                <person name="Hansson D."/>
                <person name="Henrissat B."/>
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                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
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    </feature>
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            <end position="103"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="353" mass="40345" checksum="7E424A485269D3E1" modified="2014-03-19" version="1">MSSSESIYLSSEDTLVERPYEETPSTEPSIPSTPKMSIVEERSVPWDTDEEQVAQEAEEGFSEYLEVLDEDKRRQDEMIRQLTEDFDRPSPSRSPSPPPLIRTQSEGIIFPDRETYLTTFIAYIMGLIEGTPNTEFVSGPTRPEIQRALEILEEERSFVQHAQRALQIREGILIARINAGERRLMGLNQTPHLQDSFHPADDITPLWYLVPRLRPQMEHRFAQCRGLIPWNAAGEEIFIDSRRFHPATTSYPRDWDMTPASPTPSPSSSALEVLEERDDDVWYDVKLLGQTTVRIHWAGTHCHNETRDSVSERSSRMVGNKILQRRVEALGYPLLSNLRTAVHTVSSDSKALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4KQ18</accession>
    <name>W4KQ18_HETIT</name>
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        <recommendedName>
            <fullName evidence="10">Bromo domain-containing protein</fullName>
        </recommendedName>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
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            <taxon>Heterobasidion</taxon>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11 12">TC 32-1</strain>
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        <subcellularLocation>
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        </subcellularLocation>
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    <dbReference type="OrthoDB" id="6017at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0003682">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF19">
        <property type="entry name" value="PROTEIN POLYBROMO-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="81"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="225"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <end position="206"/>
        </location>
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            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="389"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
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            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
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            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW87156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="650" mass="70765" checksum="39DBECBF836970FA" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4KQZ7</accession>
    <name>W4KQZ7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_243376</name>
    </gene>
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        <lineage>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Bondarzewiaceae</taxon>
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            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_243376"/>
    <dbReference type="eggNOG" id="ENOG502STZU">
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    <dbReference type="HOGENOM" id="CLU_141768_1_0_1"/>
    <dbReference type="InParanoid" id="W4KQZ7"/>
    <dbReference type="OrthoDB" id="3349961at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW87486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="106" mass="12808" checksum="3023D8B470F015AF" modified="2014-03-19" version="1" fragment="single">RRQESPWEVVDSKSVEPVSIWDDEEVQSRPFPDLEIIYIHDTPVTRTYVFDIKKEKDFENALSFAQQQLLQEVRTKGYNVLWHESWRVTLFRKGKKHRVEVRYSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMU4</accession>
    <name>W4JMU4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Impact N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_332476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553344.1">
        <property type="nucleotide sequence ID" value="XM_009555049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JMU4"/>
    <dbReference type="STRING" id="747525.W4JMU4"/>
    <dbReference type="GeneID" id="20671733"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_332476"/>
    <dbReference type="eggNOG" id="KOG3299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075864_0_0_1"/>
    <dbReference type="InParanoid" id="W4JMU4"/>
    <dbReference type="OrthoDB" id="69641at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF25">
        <property type="entry name" value="PROTEIN IMPACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00910">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Impact N-terminal" evidence="2">
        <location>
            <begin position="27"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW74877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="250" mass="27298" checksum="FD936CA5A3A40053" modified="2014-03-19" version="1">MATLDAFVDRKKPLPESIATSQEIRDRSSTFTGNIFRATTPAEAQKAVTHLRRVVHGSKPASHEIAAWRCMVLKPGKTGLSSDDDFEVQEGSDDDQESWAGSRVLKVMQAEAVIDAVVIVSRWYGGVMLGPIRFTHIETCAREVCRAFRLKDEVEDCLSTLNTLDDILTDLRAELSRLRALATPVTAGPSNDSSTEGVQLPARTTKKKQDYSGLLKDLDAAKAKRLVTARENAIKSVKASITKAKTDAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMV0</accession>
    <name>W4JMV0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_461453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553262.1">
        <property type="nucleotide sequence ID" value="XM_009554967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JMV0"/>
    <dbReference type="GeneID" id="20677172"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_461453"/>
    <dbReference type="HOGENOM" id="CLU_035509_11_4_1"/>
    <dbReference type="InParanoid" id="W4JMV0"/>
    <dbReference type="OrthoDB" id="2958007at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="22"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW74784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="214" mass="24036" checksum="955FFC53CDE4674D" modified="2014-03-19" version="1">MSSPPDPSEVLRGLSHLNVETYINVCAVVVLLYDYLLTLHYEVKYIWPSKWSLSKVLFLCTRYPAFIDTSLVIWLQFGHNLSPNVCTTLYDLIGWLIMFGIAVAECIIILRTVALWGGRRSVKYSLLAVFTLTFIAASIALGKFQSTTRFIPTESLGNFSTGKGCLVGKASVDVIGTYISFTVFDTVIVTLTMIKAMKLRRRMLQTQITLFVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMX3</accession>
    <name>W4JMX3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSM4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM4</name>
        <name evidence="12" type="ORF">HETIRDRAFT_57322</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553064.1">
        <property type="nucleotide sequence ID" value="XM_009554769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JMX3"/>
    <dbReference type="FunCoup" id="W4JMX3">
        <property type="interactions" value="251"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JMX3"/>
    <dbReference type="GeneID" id="20678392"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_57322"/>
    <dbReference type="eggNOG" id="KOG3293">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099537_2_1_1"/>
    <dbReference type="InParanoid" id="W4JMX3"/>
    <dbReference type="OrthoDB" id="747253at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097525">
        <property type="term" value="C:spliceosomal snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01723">
        <property type="entry name" value="LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000024">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034101">
        <property type="entry name" value="Lsm4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sm"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
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            <begin position="1"/>
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            <begin position="100"/>
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            <position position="1"/>
        </location>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU365049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW74809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="120" mass="13218" checksum="81AD2A1067DF7CB4" modified="2014-03-19" version="1" fragment="single">LPLSLLNAAQNKPMLVELKNGETFNGHLINCDNFMNITLREVYQTSADGDRFWKVKECYIRGSTIKYLRVPDTLLDAVKEEQARAREAGKSARGAHISGAGRGMPRGGPMRGRGGRGRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4JN58</accession>
    <name>W4JN58_HETIT</name>
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        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_442797</name>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000030671">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW74997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="25182" checksum="1AC559721707AA81" modified="2014-03-19" version="1">MAAHHFCCCLPLRLGAFLISLFQFLLSGIAAAALWYGLAHWPSDVSAKLKGATVGAGVYYTILALAAFIGFIGTIRRSIKMLSTYSFWLGWALGLQIALDAFLLYAYFTTPREDLVRNCVKDSTDQNVINSCNSAFNVGKGAMIGGVVVNLLIQAYAVYIVSSYGKKLELEHAWTSNVPLDAGYKYVATGRASTEGLTAPHYTYPYADGSNSFGHSGAQYDPPAPHAHHAQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">HETIRDRAFT_482638</name>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Solheim H."/>
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                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
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                <person name="Stenlid J."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="FunCoup" id="W4JP39">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JP39"/>
    <dbReference type="GeneID" id="20678044"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_482638"/>
    <dbReference type="eggNOG" id="KOG3780">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007709_0_0_1"/>
    <dbReference type="InParanoid" id="W4JP39"/>
    <dbReference type="OrthoDB" id="2238745at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin protein ligase binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
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    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="491"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW74835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="795" mass="88354" checksum="58FAAA609F2011FD" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPB5</accession>
    <name>W4JPB5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">HETIRDRAFT_482734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
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            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553388.1">
        <property type="nucleotide sequence ID" value="XM_009555093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPB5"/>
    <dbReference type="GeneID" id="20678051"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_482734"/>
    <dbReference type="eggNOG" id="ENOG502SXNS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132760_0_0_1"/>
    <dbReference type="InParanoid" id="W4JPB5"/>
    <dbReference type="OrthoDB" id="3198848at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW74925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="175" mass="19688" checksum="2A138441DBA08033" modified="2014-03-19" version="1">MFAQITSDQSSAPSRVAHPLALSTSHVMPVDILTYRYKDKMVYVSAAETYEEALDFAQTVYPELQLVDRSRITFDIRVVTGSMMNNVQIGSMAWTQVVSNLTRFEVIDVEVAKPLPAPRTVIDPPPQYPMDEKARPSLDKEKDRLDPNAKSSRHSRSPSPTSSKWTSLFRTSSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQ47</accession>
    <name>W4JQ47_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_53973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551866.1">
        <property type="nucleotide sequence ID" value="XM_009553571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQ47"/>
    <dbReference type="GeneID" id="20678282"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_53973"/>
    <dbReference type="eggNOG" id="ENOG502S3G3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_32_0_1"/>
    <dbReference type="InParanoid" id="W4JQ47"/>
    <dbReference type="OrthoDB" id="128646at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW75687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="126" mass="14443" checksum="802597D7BC03A542" modified="2014-03-19" version="1" fragment="single">MNDRIITPIRLNVKVSNRSQNAGAKATIDSACEGVIVNETWVKRHCFPTYTLNNPIRVRNVDDTINKAGLIRSALDVNLTIRDISGRTHTERVQMFISNLGKDDLILGTDWLKYHDPSIEWRRREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQ64</accession>
    <name>W4JQ64_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_423604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW75021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553472.1">
        <property type="nucleotide sequence ID" value="XM_009555177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQ64"/>
    <dbReference type="STRING" id="747525.W4JQ64"/>
    <dbReference type="GeneID" id="20673919"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_423604"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_33_3_1"/>
    <dbReference type="InParanoid" id="W4JQ64"/>
    <dbReference type="OrthoDB" id="2684690at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34072">
        <property type="entry name" value="ENZYMATIC POLYPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34072:SF52">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="1">
        <location>
            <begin position="57"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="171" mass="19653" checksum="6AFF911A05B10D30" modified="2014-03-19" version="1">MQILLDNNLFLKPSKCVFEVDTVKYLGFIISADSIAIGPVKVEGISKWPTPTNLKETEERNAVFETLKLCFTLTPVLIYPNGNRLFRPETNASDFVSGTILLQEVPGDGWHPVVYLLKYFNTAKQNYNIFDKELLVVIYTLDHWCIYLEAHWALFLSCFYFTLVHKPSTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4JR20</accession>
    <name>W4JR20_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_156949</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552147.1">
        <property type="nucleotide sequence ID" value="XM_009553852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JR20"/>
    <dbReference type="STRING" id="747525.W4JR20"/>
    <dbReference type="GeneID" id="20667677"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_156949"/>
    <dbReference type="eggNOG" id="KOG0758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_16_3_1"/>
    <dbReference type="InParanoid" id="W4JR20"/>
    <dbReference type="OrthoDB" id="2139348at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF31">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="21"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="122"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="254"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW75909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="350" mass="36543" checksum="36956B31BFD19678" modified="2014-03-19" version="1">METAPDAFNPAVANDRGSPTERAAKDIAFGSVAGMASKVLEHPFDLTKVRLQAQVLDSTARFSGPLDCLAQTYNKEGVRGLYRGLPAPIVGAMVENASLFLTYGELQNAVRALSGLAPTHALSLPQLALAAGGAGAITSFLLTPIELVKCKMQVQMLVSAPAALPSAPGAASVRSLPGPLAIIAHTFRTTGLRGFWLGHTGTLIRETGGSAAWFSTKEFVASLLLARHPQPYSPSSSSTDDAYDTHAAARPRDLASWESALSGACAGASYNLALFPADTVKSTMQTEAELRPGSAPAGGGGRSFWGVGREMYRAQGIRGLYAGCGVTVARSIPSSAVIFWIYDGLKARYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRA3</accession>
    <name>W4JRA3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_53797</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551857.1">
        <property type="nucleotide sequence ID" value="XM_009553562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRA3"/>
    <dbReference type="STRING" id="747525.W4JRA3"/>
    <dbReference type="GeneID" id="20678272"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_53797"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010228_1_2_1"/>
    <dbReference type="InParanoid" id="W4JRA3"/>
    <dbReference type="OrthoDB" id="1405469at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000306">
        <property type="entry name" value="IKS protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF138">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE IKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="172"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="272"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW76102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="602" mass="65277" checksum="18B2D077F805401A" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2024-07-24" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRB0</accession>
    <name>W4JRB0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_426104</name>
        <name evidence="1" type="ORF">HETIRDRAFT_430904</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544752.1">
        <property type="nucleotide sequence ID" value="XM_009546457.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553021.1">
        <property type="nucleotide sequence ID" value="XM_009554726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRB0"/>
    <dbReference type="GeneID" id="20674075"/>
    <dbReference type="GeneID" id="20674492"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_426104"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_430904"/>
    <dbReference type="HOGENOM" id="CLU_924557_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW75625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="301" mass="34101" checksum="5230ED9367ADE870" modified="2014-03-19" version="1">MELTQSKKAPLSVDISPRFCAPKVDFFPQYTNLFIPELTHIKDLTLHINSDDPSCLVDLIRSPMPTLEYCNFYINNFSSFPNLIFLKLTNWRNGRMTFEALAKGIKQLSLLQMLSLSHVFTYTHVSNNVMGSIADDSIDLPCLQNLIFHGRALECARFLTALQLETLNRSALHLEAEIEAPVHVEDIILVVSSAAPYISGKRTGVIVVKLAFDQTIWGVHITLWNEEEYIHGHGITISLNGVWGVDFESLFTVIYPKLRIIPNLTMTLLGIRSYRTSEFINTLAAGVTIEWVDEEEEEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRQ2</accession>
    <name>W4JRQ2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_329423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552454.1">
        <property type="nucleotide sequence ID" value="XM_009554159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRQ2"/>
    <dbReference type="STRING" id="747525.W4JRQ2"/>
    <dbReference type="GeneID" id="20671490"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_329423"/>
    <dbReference type="eggNOG" id="ENOG502QUF5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044503_1_0_1"/>
    <dbReference type="InParanoid" id="W4JRQ2"/>
    <dbReference type="OrthoDB" id="2343366at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="221" mass="24073" checksum="2220E54C61D835F9" modified="2014-03-19" version="1">MTCSDRRPLLDTPSSTLIRQRADNRYGAALSSLYSFLAARRSLIRSATGARNDAYSVVTFSSSARTRVTNDFSSTPDQLLSLLLTQEEAGGTNFDAALKEAQQTMQSSFSSERAPVLIFLSDGECSVRDETVYDICRKAVTLGKPLSFHAVSFGQDYSSSQLRRMAQLAEEVYSTAPQDQLASTATISCSYTNAIDTIQLTETFLGIADSLTKTRASLIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSX3</accession>
    <name>W4JSX3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_436575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551545.1">
        <property type="nucleotide sequence ID" value="XM_009553250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSX3"/>
    <dbReference type="GeneID" id="20674896"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_436575"/>
    <dbReference type="HOGENOM" id="CLU_2015566_0_0_1"/>
    <dbReference type="InParanoid" id="W4JSX3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="123" mass="13434" checksum="271689163E994712" modified="2014-03-19" version="1">MINVSGEPRKIGNGVRGLKDVQDVDGRAAGLAVVDDIYWCLPIRATTSSCHPLRLTALRSLSWPRCIAQRHRTIPSTSTSIDCGIEATEDRVTQLISACHIMFQPPAPTRCSSSVSENNENML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTE2</accession>
    <name>W4JTE2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_328945</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551608.1">
        <property type="nucleotide sequence ID" value="XM_009553313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTE2"/>
    <dbReference type="GeneID" id="20671458"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_328945"/>
    <dbReference type="eggNOG" id="ENOG502S3G3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_676251_0_0_1"/>
    <dbReference type="InParanoid" id="W4JTE2"/>
    <dbReference type="OrthoDB" id="8955945at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="334"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW76734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="407" mass="45354" checksum="DFF1D78F4CC91B95" modified="2014-03-19" version="1">MSGQASTSTNTPSTTVQPGRGKVKLPDNYTGDRIESQKFMLQCLLLFAAESDRYKTNQDKISLVLSCMRYGTAGAWAENFLLRSVGADPPTDLGTWKDFLAKFKLQFRETGKTDKARSALMAFSQGRMTVDEYSNQFILIAADADISEKEQVPYFQRGLDPRVMDKIYDKEVQPKDTIQDWINTACEIDGRLRARTAQKAILANSTSFRSDYLSRFHNQISPRYNSTNAPRRMNNQVVDMDIDATRKRNALSQKRKHDGKPPGACYHCGKTGHWNADCPSLRRGVRPIRGNSKKCMGTTGRRSRAVDLEGEDDAPAMGDQAGIYRGMETEDVHRNNQRVPQPGPSMERPHSTPSGRPQTNHGQRAMLPNGRRGDGGVSHSARIGAVLGELGKDEAREVILGHAERFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTU1</accession>
    <name>W4JTU1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_106703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552476.1">
        <property type="nucleotide sequence ID" value="XM_009554181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTU1"/>
    <dbReference type="STRING" id="747525.W4JTU1"/>
    <dbReference type="GeneID" id="20666185"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_106703"/>
    <dbReference type="HOGENOM" id="CLU_2158763_0_0_1"/>
    <dbReference type="InParanoid" id="W4JTU1"/>
    <dbReference type="OrthoDB" id="3201656at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="111" mass="12505" checksum="6AE055C74A068805" modified="2014-03-19" version="1">MVVKALTTKMGVTGCGQYLEDALIDGWEADIKSTTTEILDNDLRLATFLVKAWIDENSMSVTMEELKEKLTKVQAVVNPITSKMYESVGTRLSYKPGLDDEQEPFHLYDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTX7</accession>
    <name>W4JTX7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_326628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550573.1">
        <property type="nucleotide sequence ID" value="XM_009552278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTX7"/>
    <dbReference type="STRING" id="747525.W4JTX7"/>
    <dbReference type="GeneID" id="20671257"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_326628"/>
    <dbReference type="eggNOG" id="ENOG502SPCC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_681853_0_0_1"/>
    <dbReference type="InParanoid" id="W4JTX7"/>
    <dbReference type="OrthoDB" id="2535105at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="188"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW77017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="344" mass="38792" checksum="3B3A15FFBD53ECF7" modified="2014-03-19" version="1">MPSLIPLDDSLGATYIGVIVSTGIYGVTCLQVYLYYTQHCSNDGRFLKAFVAILTLLDTFHVVLLAHFMYIYTVANFGDYRALVPLCFLIEFVIGDLLSVLVQIFFAYRIYCLSGRRTLIPPASIPRTSMFGTLDLLRRPKADEVNITTAGALGEVLRSTVIGFRAPTFFSERSEILLWTIISTAVEISCDVLITGFMIFHLRKCRTQFERTNRAINLLITYTLNTSALTNLVKFLTLHQSLVFTAFFFILVRLYFCSFMSSLNSRDFVRQELNSKQDEVITLSRFAAAEAGVSLQREDTVGRSVESHKGFECSSSKLHHTDDIATEDQTNMFDRLPIGLLDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JU37</accession>
    <name>W4JU37_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_429445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550618.1">
        <property type="nucleotide sequence ID" value="XM_009552323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JU37"/>
    <dbReference type="GeneID" id="20674345"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_429445"/>
    <dbReference type="HOGENOM" id="CLU_2210402_0_0_1"/>
    <dbReference type="InParanoid" id="W4JU37"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW77068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="107" mass="12209" checksum="20266E2E111443E2" modified="2014-03-19" version="1">MTTLQVLDYVVKAHTILDLLHGPVAIVVECKRATILASKLYLWHSWLLKDESRGVSPQLLLKSWKKLREVGLDFLIAKGNNMTEWCTMLVTAELEMVLLKVMIEKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUB8</accession>
    <name>W4JUB8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_152123</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550691.1">
        <property type="nucleotide sequence ID" value="XM_009552396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUB8"/>
    <dbReference type="STRING" id="747525.W4JUB8"/>
    <dbReference type="GeneID" id="20667403"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_152123"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_5_11_1"/>
    <dbReference type="InParanoid" id="W4JUB8"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW77148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="550" mass="61302" checksum="C1D63D6C9FE18C64" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUH6</accession>
    <name>W4JUH6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein LCHN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_421978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551427.1">
        <property type="nucleotide sequence ID" value="XM_009553132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUH6"/>
    <dbReference type="STRING" id="747525.W4JUH6"/>
    <dbReference type="GeneID" id="20673766"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_421978"/>
    <dbReference type="eggNOG" id="KOG4704">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_442816_0_0_1"/>
    <dbReference type="InParanoid" id="W4JUH6"/>
    <dbReference type="OrthoDB" id="2152680at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018626">
        <property type="entry name" value="LCHN/Anr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053056">
        <property type="entry name" value="Lipid_Metab_Assoc_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28153:SF1">
        <property type="entry name" value="DUF4484 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28153">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09804">
        <property type="entry name" value="DENND11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="604" mass="66126" checksum="3CD662E1A7D9CF8B" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVD1</accession>
    <name>W4JVD1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chloroperoxidase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cpx4</name>
        <name evidence="10" type="ORF">HETIRDRAFT_156524</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550944.1">
        <property type="nucleotide sequence ID" value="XM_009552649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JVD1"/>
    <dbReference type="GeneID" id="20667641"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_156524"/>
    <dbReference type="eggNOG" id="ENOG502QTVQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050230_1_0_1"/>
    <dbReference type="InParanoid" id="W4JVD1"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF18">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="60"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW77439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="298" mass="32435" checksum="A22A0F1F134A10D9" modified="2014-03-19" version="1" fragment="single">MVLLFALQRISLGIATSLINAVVNIGIILWDLGLFIYNLLIPLRAVGKVTPMGHPGAGGKWPEYIPPKEGDSRCSCPALNALANHGILPRNGRNIPIRALTPAIRSTYNFAPSFCVFVPRYIGQILGRSYLNDTLDLEDIDVHNGIEHDASLTREDARVSPDQSRPSIPLVEQLLASASGPLLSNRTGDSSVTPTLTVSDLARLTSKRRAEAKKQNGQFSLSTSHKMFGSSNSGTLLTIFGGRVDDLRTVLLEERLPDGWESRVREPMGLTIAVFNKTVLGIEMGVEEEIRDGLKSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVJ8</accession>
    <name>W4JVJ8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_421685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551051.1">
        <property type="nucleotide sequence ID" value="XM_009552756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JVJ8"/>
    <dbReference type="GeneID" id="20673741"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_421685"/>
    <dbReference type="HOGENOM" id="CLU_2469372_0_0_1"/>
    <dbReference type="InParanoid" id="W4JVJ8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="88" mass="10055" checksum="96F5DC4E6BC1E0BD" modified="2014-03-19" version="1">MERKLETSREILSKPREERWLRNRCLTYCGKFRENYAVSSHPSASFPPTDYDTDIDSTRGAGLNSKNPLKAFFQIVSLSLRAEGGLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVK3</accession>
    <name>W4JVK3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_18644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550457.1">
        <property type="nucleotide sequence ID" value="XM_009552162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JVK3"/>
    <dbReference type="GeneID" id="20668623"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_18644"/>
    <dbReference type="eggNOG" id="ENOG502SXYS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_32_0_1"/>
    <dbReference type="InParanoid" id="W4JVK3"/>
    <dbReference type="OrthoDB" id="2676613at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW77572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="98" mass="10830" checksum="43A3FCAD5E39E5D0" modified="2014-03-19" version="1" fragment="single">LIGKNRKAATQALVDSGATGIFMHPRFVETHRIKTRKTPAPIPVNTVQNTEFKGGPITKFAELKLQVLGEQGGTHTESAKFYIAEIRKEDVILGTDWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVN9</accession>
    <name>W4JVN9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_118360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551032.1">
        <property type="nucleotide sequence ID" value="XM_009552737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JVN9"/>
    <dbReference type="GeneID" id="20666583"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_118360"/>
    <dbReference type="HOGENOM" id="CLU_885832_0_0_1"/>
    <dbReference type="InParanoid" id="W4JVN9"/>
    <dbReference type="OrthoDB" id="3350812at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="25"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW77544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="314" mass="35875" checksum="9BA997E1441FEA9D" modified="2014-03-19" version="1">MDAVLSGYTANQPELEASYTAVLKYVQAASMMLLIHDWAILFGEEGISYHIKVDLVWRARWTFPNILFLITRYTPFIDMVVNLYRSMTIGVALSEIVMLLRTYAILDRSRRVLIGLGSSWIISFILSMGFIGASVKAPSVDTGIRSFGCSSETRGMAIQVGAFASLLCMETRFAFADAVYVYSALSTWVIKFNLQHTLFGWDFLLHDHPTHVTSASHIFVAPMRVFHGLLSCRMLLNIRRVAMQHVPLALPTHLHAPELNVYPLPIYPDKELDWERPSFAPSKILWRSREVWQDHKSRNGVHESFMEMQSWLQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVX8</accession>
    <name>W4JVX8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_454875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551108.1">
        <property type="nucleotide sequence ID" value="XM_009552813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JVX8"/>
    <dbReference type="GeneID" id="20676562"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_454875"/>
    <dbReference type="HOGENOM" id="CLU_1981863_0_0_1"/>
    <dbReference type="InParanoid" id="W4JVX8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="126" mass="13294" checksum="786CA73A3A0A67B8" modified="2014-03-19" version="1">MSASAAIAPTSAITILAFPHTPLSSDIDPASVLSPRQLPPPRIHFLLSHPLSSSPPLKSTTRVSVPLGLAQALHDPSSALCPALSTRPLRANDQSKPTWAILNDLRTLPRPGEARSPSRADPAHHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVY3</accession>
    <name>W4JVY3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_326533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551113.1">
        <property type="nucleotide sequence ID" value="XM_009552818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JVY3"/>
    <dbReference type="STRING" id="747525.W4JVY3"/>
    <dbReference type="GeneID" id="20671249"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_326533"/>
    <dbReference type="eggNOG" id="ENOG502SRBJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048760_0_0_1"/>
    <dbReference type="InParanoid" id="W4JVY3"/>
    <dbReference type="OrthoDB" id="3254241at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW77634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="415" mass="46242" checksum="2A0BA78E8B4CCAB4" modified="2014-03-19" version="1">MDPISVVQAIFSTAVAIQKWIDLSNSRNSTIRELKTTVSRISSILSPLLPISSQSQPSTVVSPRLNPATISCLQDLGETLSRTREHLSLWTDKRSKRVALLSFLSPSTVLDELQDDEKRISQRVSILAFALQVSDMSSGNQAGSVTDRQPSAVSFLASEEVRKFWTQTIGNEVSCCPGKPFCASLSHWLNIRIDEDTRDILLLRLDEFAVGGVTPSSLDQFVGQRTMLDALNQIGVMRRMNSLELASSIANPQTTDLLLIWIDDNPTNNEHHISHAHSLGITVVTLMSTASAKVWIEANDKILRRADQARRLRFISDNARWESSSESGLPYSDFLNLSAGETILRYLRGRQFTTPVLIFSGASINLTHYVLSYLNTGSTWYDDIVSRYIEALQSGRDDRSWIGFNVEPSYTNDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWC1</accession>
    <name>W4JWC1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_105642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550726.1">
        <property type="nucleotide sequence ID" value="XM_009552431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWC1"/>
    <dbReference type="GeneID" id="20666082"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_105642"/>
    <dbReference type="HOGENOM" id="CLU_1906980_0_0_1"/>
    <dbReference type="InParanoid" id="W4JWC1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW77186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="133" mass="14520" checksum="CAE19350952B6ABF" modified="2014-03-19" version="1">MAVGNAYDLSLLKSDDLLPRRPVSPNIAPLLSFFIQQMIDVATFLVPQCLSNRSDHYQQSRYVLVSAGFSTLAASSSFKNLHYSFALLSEFRQADAQLERAAEAGTLRTTSPGSYPVTPIHPVLCRAGGNNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXM4</accession>
    <name>W4JXM4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_411136</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549843.1">
        <property type="nucleotide sequence ID" value="XM_009551548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXM4"/>
    <dbReference type="STRING" id="747525.W4JXM4"/>
    <dbReference type="GeneID" id="20672923"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_411136"/>
    <dbReference type="eggNOG" id="KOG1231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_10_0_1"/>
    <dbReference type="InParanoid" id="W4JXM4"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="32"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW77820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="463" mass="50256" checksum="B5E721144F7937FC" modified="2014-03-19" version="1">MADIESLKIQGNVLSPASAGYREALQRNSDLSILEAAYVIQPAVYTDIPIILSYALSHSPRFEIAVKGGGCHSSTWSSTQGGIVIDLSLLNLVKLSDDRKTIVIQGGANWGNVYEVGSKEGIEVAGAPLWFVGVGGSLLGGAYGNLTSEHGLGIDNMVAATVVLADGRIVKTSATEEPDLFWAIRGGGNQFGIVVEFVLKAFPSPGPSTVGALVYPGTAFADVIQVVQDFVSAASVHEKVSMMFTRPGPHFKPTIVIAPWISAASSRSAEEILAPFRIRVTPTVDRISSAPDQLTISHSADAGLSRAPRRLTIRGVAFSELWTDMITEVWVRWCKFTEDNEDARSSMVLWDTRQWEKIVQVGREETAFAIRRPHYSVAIQGRNSRPETDEASRAFVASTVEFIRRTNVEKTGDDLGILLNMAQGDEPADAVFGLNLPRLRKLKAKYDPGRLWTKGFVIEPESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXN7</accession>
    <name>W4JXN7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_55694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXN7"/>
    <dbReference type="STRING" id="747525.W4JXN7"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_55694"/>
    <dbReference type="eggNOG" id="ENOG502SC7R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1807558_0_0_1"/>
    <dbReference type="InParanoid" id="W4JXN7"/>
    <dbReference type="OrthoDB" id="3444765at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="149" mass="16921" checksum="41AD3AF7C155717C" modified="2014-03-19" version="1" fragment="single">RGIPSKRESSARVDYVPALCTHRPSLLPIEWLSETSGLALGSRQRHPIAEKLVKLGHLEENSVNHRIFERTLRPLVFRRARLFECREILNPRDPCGAVPGVIIVYAVGYATIVGDLLPTVERQLYRNLTSNQAGLPAELKHINKRRKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXS6</accession>
    <name>W4JXS6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_435747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549728.1">
        <property type="nucleotide sequence ID" value="XM_009551433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXS6"/>
    <dbReference type="GeneID" id="20674845"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_435747"/>
    <dbReference type="eggNOG" id="ENOG502SPDB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119633_0_0_1"/>
    <dbReference type="InParanoid" id="W4JXS6"/>
    <dbReference type="OrthoDB" id="5327923at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW77691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="238" mass="27260" checksum="71BA6C6DE5757810" modified="2014-03-19" version="1">MRLSAGSMLGEGHHSSVYLSALTLPRPLSARTLTGEVSVACKMSDPDPEAREHLENEAKIYASFPKHLQEDWCGLNMMPPIKTPVPACAVVPKFYGYYKPAFDEEAFRSESEEVRAEMKAFIERLSPILLMEHCGIPIVTSKNFHVDKKILCYSMLRRLHINDYIHNSFYQRNVLVQPGPLTRPPEERSMKMPSYRVIDFGRSELYGPSNDKMSEYDAGWGNELYRATEELNMEPFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXY5</accession>
    <name>W4JXY5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Macrophage erythroblast attacher</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_157383</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FYV10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549968.1">
        <property type="nucleotide sequence ID" value="XM_009551673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXY5"/>
    <dbReference type="FunCoup" id="W4JXY5">
        <property type="interactions" value="452"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JXY5"/>
    <dbReference type="GeneID" id="20667724"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_157383"/>
    <dbReference type="eggNOG" id="KOG0396">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027445_2_0_1"/>
    <dbReference type="InParanoid" id="W4JXY5"/>
    <dbReference type="OrthoDB" id="1933455at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16659">
        <property type="entry name" value="RING-Ubox_Emp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN TRANSFERASE MAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CTLH" evidence="8">
        <location>
            <begin position="157"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="RING-Gid-type" evidence="9">
        <location>
            <begin position="309"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="7">
        <location>
            <begin position="309"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW77955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="44846" checksum="2CF5689251E3DF79" modified="2014-03-19" version="1">MSNSKLNTEGVLLFEQPFAKVPYENYRKVFRTAQKNIERELGAVRSIAKDVPNASHPQEAINLVDIMIGRVENLKRKLSDLHEGPGSSAQAIMRERVNHLSCLDTVQSANDPEYTRWADARLDRWLVDWALRHGNEKTARKIAQEREIETLVDIDLFMDIRRIEDALKRHSCLEALAWCSENKTALRKLKSTLEFDLRLQEYIELARARRTQEAIAYSKKHLASWQETHIAQIQQASALLAFPPTTNCGPYKRLYDRGRWNNLILAFRLAIFNLNSLPSEPLLHLALYGGLASLKLSACYDPGTQNRDCPVCDASFRELAKEVPFSHHVNSTIVCRLSGRIMDENNPPMAFPNGYVYSREALEEMAIKNEGIVTCPRSGEQCEYSKLKKVFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYM9</accession>
    <name>W4JYM9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_326421</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550197.1">
        <property type="nucleotide sequence ID" value="XM_009551902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYM9"/>
    <dbReference type="GeneID" id="20671239"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_326421"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004645_1_0_1"/>
    <dbReference type="InParanoid" id="W4JYM9"/>
    <dbReference type="OrthoDB" id="446925at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="9">
        <location>
            <begin position="367"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW78205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="498" mass="56598" checksum="7D8BB99D95B9DF46" modified="2014-03-19" version="1" fragment="single">MLTRKDFPFVFGPDQIAAQDDLRSALLESPALRPIDYGSAANVILAVDTSQIAVGFHLCQCALDNPRVRYYARFGSITLNDRESRFSQPKLELYGLFRALRSLKMYLIGVRNLIVKVDARYIKGMLTNPDLEPSASINRWIVSILTFHFTLVHVPGTSHGPDGLSRRPPQPTDRPEPEDNFDDWIDNLYGFLHQINNTFPTSISTSTTAIFTSSLIGDPPTNTGSDDEGPTIDYSDIPRSQKALEAEERLWSVRDWHRTLVRPPSLSDSEYATFLQYCTEFFIAADKLWRKDSHGQHKIVAAPSSRITILTAAHDDVAHKGFYATTALIAERFWWPHMRQDISWFVRTCHLCQIRQTRNVLIPPTIATPAPLFAKMYMDTMHMPTAGGFKYLVQGRCSVSHYPEFRMLRRETSSALADWIFEDILCRWGTLVEIVSDNGPAFVKALDQLAKKYHVRHIRISGYNSRANGIAERPHFDVRQALFKAVDGDQAKWNRAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYS1</accession>
    <name>W4JYS1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_163995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550021.1">
        <property type="nucleotide sequence ID" value="XM_009551726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYS1"/>
    <dbReference type="STRING" id="747525.W4JYS1"/>
    <dbReference type="GeneID" id="20667884"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_163995"/>
    <dbReference type="eggNOG" id="ENOG502RD5E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081631_3_2_1"/>
    <dbReference type="InParanoid" id="W4JYS1"/>
    <dbReference type="OrthoDB" id="3830579at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="21268" checksum="050101488382F9E6" modified="2014-03-19" version="1">MAAIPAIEIVNWVASTAYLNDPSVIDEGIKFVLNVTGVLDVWNGLQTERPNTYLATAWTSIEAHEALEADKARYAQSLALLAPAMAADPEAVLFHADLDPDYPLVFNSPATEFVQVLPNDGVTANTTSSLLAQLKEDAVKTCGALAASWGPIVEQAQTLMAVVGWKSVSEANDACFADITKDLQASATLTLSHAHMREGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZJ2</accession>
    <name>W4JZJ2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Metallo peptidase M20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_147361</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549250.1">
        <property type="nucleotide sequence ID" value="XM_009550955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZJ2"/>
    <dbReference type="FunCoup" id="W4JZJ2">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JZJ2"/>
    <dbReference type="MEROPS" id="M20.002"/>
    <dbReference type="GeneID" id="20667197"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_147361"/>
    <dbReference type="eggNOG" id="KOG2275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_11_0_1"/>
    <dbReference type="InParanoid" id="W4JZJ2"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05674">
        <property type="entry name" value="M20_yscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="6">
        <location>
            <begin position="176"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW78967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="475" mass="51588" checksum="1318E4C425D73F57" modified="2014-03-19" version="1">MEPVGVDPRWDAFGPFHDYLAKAYPLIHSKLEITKVNTYGLIYVWKGSDESLKPLLLAAHQDVVPVDPRTVDEWEHPPYSGHFDGESVWGRGSSDDKSGLIGVMSTIESLLEKDFHPTRGIVLSFGFDEETSGLHGASKLAEYLLSTYGENSFALLVDEGGSFSEQHGSIIATPGIAEKGYIDTRIEVASPGGHSSIPPSHTSIGILSALLVELEAHPFEVHLSRGTPVYATVQCLAAHAKNLPQKLRASIKASAKSDKALKKAEKELFVDPAFKALVGTTQAIDLIQGGVKTNALPEQAWAVVNHRLATESSVAETKHRDTEALKVLAQQFNLSYTAFGAAISAKDAPAYGSLTLTDAWGTALEPAPITPTDSDAVPYRILSGTIRATYDSHRDLVGGDNIFVSPGIMSGNTDTRYYWKLTSHIFRYNHHNSGNGSALANGVHTVNEHIRIVDFVEIIRYFTTLILNVDESTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4K035</accession>
    <name>W4K035_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">quinol--cytochrome-c reductase</fullName>
            <ecNumber evidence="3">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HETIRDRAFT_36149</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 22">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="17">Binds 1 heme c group covalently per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3"/>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548746.1">
        <property type="nucleotide sequence ID" value="XM_009550451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K035"/>
    <dbReference type="FunCoup" id="W4K035">
        <property type="interactions" value="271"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K035"/>
    <dbReference type="GeneID" id="20671815"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_36149"/>
    <dbReference type="eggNOG" id="KOG3052">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040334_1_1_1"/>
    <dbReference type="InParanoid" id="W4K035"/>
    <dbReference type="OrthoDB" id="5925at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000002">
        <property type="entry name" value="Cytochrome c1, heme protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000003">
        <property type="entry name" value="Cytochrome c1, heme protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002326">
        <property type="entry name" value="Cyt_c1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021157">
        <property type="entry name" value="Cyt_c1_TM_anchor_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266">
        <property type="entry name" value="CYTOCHROME C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266:SF3">
        <property type="entry name" value="CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02167">
        <property type="entry name" value="Cytochrom_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00603">
        <property type="entry name" value="CYTOCHROMEC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81496">
        <property type="entry name" value="Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 17 18" id="KW-0349">Heme</keyword>
    <keyword evidence="13 17 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="19">
        <location>
            <begin position="114"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR602326-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ETW79089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="335" mass="36274" checksum="678B238F641EE429" modified="2014-03-19" version="1">MLSRLPAAALNNSATFAAARSASLRTATRSGTQQVRFASSGAASSNAAQSFINSRATLASATLLTAGSIAWYTHLYGSLPFIGEVHASSPAEDGLHPPAYPWSHKGLLNTFDHASIRRGYQVYREVCAACHSLDRIAWRNLVGVSHTADEARALAEEVEYTDGPNDQGEMFQRPGKLSDYMPAPYPNEEAARASNGGALPPDLSLIVKARHGGADYLFSLLTGYVDAPAGVEIREGMNYNPYFPGGAISMPRVIFDGLVEYDDGTPATTSQLAKDVTTFLNWAAEPEHDERKKMGLKAVILFSALTAISLYVKRFKWSVIKSRKIFYSPPVDKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0F2</accession>
    <name>W4K0F2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_50608</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548786.1">
        <property type="nucleotide sequence ID" value="XM_009550491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0F2"/>
    <dbReference type="STRING" id="747525.W4K0F2"/>
    <dbReference type="GeneID" id="20678151"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_50608"/>
    <dbReference type="eggNOG" id="KOG3467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109117_4_0_1"/>
    <dbReference type="InParanoid" id="W4K0F2"/>
    <dbReference type="OrthoDB" id="2532770at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000007">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="11">
        <location>
            <begin position="35"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW79278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="94" mass="10507" checksum="EE2BD9DA86777466" modified="2014-03-19" version="1" fragment="single">GLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKIFLENVIRDSVTYTEHAKRKTVTALDVVYALKRSGRTLYGFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0G6</accession>
    <name>W4K0G6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_324250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548952.1">
        <property type="nucleotide sequence ID" value="XM_009550657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0G6"/>
    <dbReference type="GeneID" id="20671036"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_324250"/>
    <dbReference type="HOGENOM" id="CLU_2498141_0_0_1"/>
    <dbReference type="InParanoid" id="W4K0G6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="86" mass="9860" checksum="E4B2A1C9113D3A6A" modified="2014-03-19" version="1">MPDVPQRLSSTEELHTSIPCRSFLERGLICRALMYSYCTSMYLLYLLVRNLIVEHLGELNTVEIVNAIELDLPSTHHGMRQNLSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0G9</accession>
    <name>W4K0G9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_410753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549113.1">
        <property type="nucleotide sequence ID" value="XM_009550818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0G9"/>
    <dbReference type="GeneID" id="20672897"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_410753"/>
    <dbReference type="HOGENOM" id="CLU_1643915_0_0_1"/>
    <dbReference type="InParanoid" id="W4K0G9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="161" mass="15990" checksum="4B8A754CEFC6BC9D" modified="2014-03-19" version="1">MAAVSAPAVPAASTSWAAPSTSAMGPMAVMSASAVHSASTTGEPSVNQAAAPSTWSLSPSSSVRDFDAASASTWVPSSQSASVADVQPTPSHPAPALSPSPSESGTPPSFVPSPSASAHPLGVQVVAEDPQPSSSASSEAPMMTPASTDPYAWMFRPDVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1K2</accession>
    <name>W4K1K2_HETIT</name>
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        <submittedName>
            <fullName evidence="4">Tridomain enzyme adenylation-thiolation-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nps7</name>
        <name evidence="4" type="ORF">HETIRDRAFT_171792</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548250.1">
        <property type="nucleotide sequence ID" value="XM_009549955.1"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K1K2"/>
    <dbReference type="GeneID" id="20668364"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_171792"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002220_2_1_1"/>
    <dbReference type="InParanoid" id="W4K1K2"/>
    <dbReference type="OrthoDB" id="5673at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00823">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
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    </dbReference>
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        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="770"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW79687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1288" mass="141442" checksum="1E58352E5E032BF4" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1K6</accession>
    <name>W4K1K6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_419291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548173.1">
        <property type="nucleotide sequence ID" value="XM_009549878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1K6"/>
    <dbReference type="GeneID" id="20673557"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_419291"/>
    <dbReference type="HOGENOM" id="CLU_2373056_0_0_1"/>
    <dbReference type="InParanoid" id="W4K1K6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="95" mass="10649" checksum="793946E1EA5B2BF2" modified="2014-03-19" version="1">MRQPIFNEARASLRISAHLSSSVPICLCQFRPPSGVASDQARTTADFSSDVRYDVIRDFVGEKHGKTHLPRQVYRPCNVGMIGKTNASGMWKFHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1N8</accession>
    <name>W4K1N8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_428722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549283.1">
        <property type="nucleotide sequence ID" value="XM_009550988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1N8"/>
    <dbReference type="GeneID" id="20674299"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_428722"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015676_0_0_1"/>
    <dbReference type="InParanoid" id="W4K1N8"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18140" checksum="E654FC1915CB646B" modified="2014-03-19" version="1">MDKQLLEGLRKRGFNLTWELEPGAGEVGLIGFLLQKSNSGTMIDFTCGQSIIDGDIQIKSGVEIDRLQPHELVLSDGSRLPADVVVLATGNLPMIMNATSLFGPRITDKIGNKIWGLDAEGELNNCFRPTGQRGLWIVTGGFQQSRFLSKHLAMQILAEELDMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2T4</accession>
    <name>W4K2T4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_322200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548645.1">
        <property type="nucleotide sequence ID" value="XM_009550350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2T4"/>
    <dbReference type="GeneID" id="20670824"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_322200"/>
    <dbReference type="eggNOG" id="ENOG502SRS6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066679_1_0_1"/>
    <dbReference type="InParanoid" id="W4K2T4"/>
    <dbReference type="OrthoDB" id="3255261at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="295" mass="33041" checksum="BF4D281BAF7C710D" modified="2014-03-19" version="1">MFSFRSHIASRKYIDLIHRETAKYANWDPSKKIEVGDYGHINRKTGEFEVEGNVYKHSSTAEKAALFPPNIGYPMLSYTVSSHVVARTGFEVTPQVGVQGIADASIKGEWQFGGKRGALLIMSHSRIESMPAELLEYITSSPLNEKGSLFKEKGLVTEIHTCPAYSLYMSAGNNEKLRLAFHVTTPIPSAPGATAGGKVGGEWWKEYDAGVYQDAAHPEGKHTFVPLFKLKKTPIRIRYRDSPPPGAMADDEWIDSPVPWHPLDEEGQEFKDDVGRRWQDECDELTSSYTGTRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3M6</accession>
    <name>W4K3M6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_419570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548471.1">
        <property type="nucleotide sequence ID" value="XM_009550176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3M6"/>
    <dbReference type="STRING" id="747525.W4K3M6"/>
    <dbReference type="GeneID" id="20673579"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_419570"/>
    <dbReference type="eggNOG" id="ENOG502SH1N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007337_4_2_1"/>
    <dbReference type="InParanoid" id="W4K3M6"/>
    <dbReference type="OrthoDB" id="2669721at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="514" mass="59193" checksum="8F27BC4E246F3C3D" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3P1</accession>
    <name>W4K3P1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_11198</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547898.1">
        <property type="nucleotide sequence ID" value="XM_009549603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3P1"/>
    <dbReference type="FunCoup" id="W4K3P1">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="GeneID" id="20666437"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_11198"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_0_3_1"/>
    <dbReference type="InParanoid" id="W4K3P1"/>
    <dbReference type="OrthoDB" id="4476201at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF6">
        <property type="entry name" value="GABA-SPECIFIC PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW79955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="494" mass="52793" checksum="C08FCA958B6A8C06" modified="2014-03-19" version="1" fragment="single">EQADENLLAALGYKQEFRRAFTPLEVFGIAFSIIGLLPSIASVLFYSIPNGGPAAMVWGWAVASFFILLVGMSMAELASAAPTSGGLYFWTHSLSAPRWRNLLAWIVGYANTIGSVASVASIDWGCAVQVMAAASIGSNETFSATNAQLYGVYAAILLSHAVLCCLGTRVLARLQSLYVVLNVMLCLAVIVALPAATPKEFRNTAKFALGNFTNLYDWPNGYAFILSFLAPLWTICSFDSSVHISEEASNAATAVPYAIVFAIAIAGILGWAINVSLAFCMGTDLQALMDAPQPMAQILFNSFGQKGTLAVWAFVVMVQYMMGSSMVLAASRQSFAFARDGALPFSSILYRMNGYTGTPVNTVGFVVALALLLGLLVFAGAQAINAVFAISVTALYIAYAIPIAARVVWRKQNGWTPGAFSLGAFSIPVAVVAVSYMCFMTVVFLFPTTRATDVPDMNYTVVVLGGILLLSVAWYYCPKYGGVHWFTGPVPTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4K437</accession>
    <name>W4K437_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor RSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pre-mRNA-splicing factor rse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_434592</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle control.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RSE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547246.1">
        <property type="nucleotide sequence ID" value="XM_009548951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K437"/>
    <dbReference type="FunCoup" id="W4K437">
        <property type="interactions" value="1170"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K437"/>
    <dbReference type="GeneID" id="20674759"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_434592"/>
    <dbReference type="eggNOG" id="KOG1898">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003246_0_0_1"/>
    <dbReference type="InParanoid" id="W4K437"/>
    <dbReference type="OrthoDB" id="436637at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001143">
        <property type="entry name" value="Pre-mRNA-splicing factor rse-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000068">
        <property type="entry name" value="Pre-mRNA-splicing factor rse1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="12">
        <location>
            <begin position="15"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="13">
        <location>
            <begin position="460"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="11">
        <location>
            <begin position="858"/>
            <end position="1177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW80509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1212" mass="133388" checksum="C8FA9F88639A9B72" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4K519</accession>
    <name>W4K519_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_452322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547534.1">
        <property type="nucleotide sequence ID" value="XM_009549239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K519"/>
    <dbReference type="GeneID" id="20676242"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_452322"/>
    <dbReference type="HOGENOM" id="CLU_2250495_0_0_1"/>
    <dbReference type="InParanoid" id="W4K519"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="104" mass="11356" checksum="E0FED9A2C44730B2" modified="2014-03-19" version="1">MASQPQSQSQPQPSLKPARDDPAMGNDGLFRRRQDSLPRSAYVCVHWTQTGRPVTMSTEMQPSGRDPRLQRAGLRNGAELEIGAITAPLGVNVGTLKDPAGYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5Q2</accession>
    <name>W4K5Q2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_320746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547772.1">
        <property type="nucleotide sequence ID" value="XM_009549477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5Q2"/>
    <dbReference type="STRING" id="747525.W4K5Q2"/>
    <dbReference type="GeneID" id="20670689"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_320746"/>
    <dbReference type="eggNOG" id="KOG3780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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                <person name="Cullen D."/>
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                <person name="Hansson D."/>
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                <person name="Lin Y.C."/>
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</entry>
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    </feature>
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    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
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    <sequence length="192" mass="21622" checksum="F34B0845354672A1" modified="2014-03-19" version="1" fragment="single">MATTTNSVIPIEPKLKDRKSYGLWAFKMERVLEARGIWNVVGGDTVTTPSTDDPALPSWKERDAKARAQIALYVEDALVISIMKAKSAHLMWEILRTLFAEQNSLNQSLVESQFYSVRMSPGQDVKLHLDLLQDLYNEAVAVGSPLEDKILVHRIITSLTSDYDSLISSITDTSKVTSEQLIARIMLEDQRR</sequence>
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                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546195.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6X7"/>
    <dbReference type="GeneID" id="20670415"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_317381"/>
    <dbReference type="HOGENOM" id="CLU_021164_3_2_1"/>
    <dbReference type="InParanoid" id="W4K6X7"/>
    <dbReference type="OrthoDB" id="3543113at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="563" mass="64515" checksum="70BCCD6446536C42" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7U6</accession>
    <name>W4K7U6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_45919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009548639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7U6"/>
    <dbReference type="GeneID" id="20676975"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_45919"/>
    <dbReference type="eggNOG" id="ENOG502S02V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066046_1_0_1"/>
    <dbReference type="InParanoid" id="W4K7U6"/>
    <dbReference type="OrthoDB" id="10006218at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026913">
        <property type="entry name" value="METTL24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026:SF10">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13383">
        <property type="entry name" value="Methyltransf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="236" mass="26589" checksum="1A57BFCC59F08472" modified="2014-03-19" version="1" fragment="single">VGDFFPPTFNCPHRVDRIGVIGDGGKWVCGIEVVAMKQECVIYSIGINGESSFEADLLDRAPGCQVWGYDYSVDSFGIEIQRFEDLKNRSHFEPWALSGKDAHGVNDKPKHYTLQTIMDLNGHNFIDILKIDIEGGEFDSLIPLLEAYVHPPSGPARPLPFGQLQLEIHAWNGRDRLDSLLPWFELMERAGLRPFRNEPNLVYLGWVKGSHPDLVEYSFINIGGDHELISGNTVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4K811</accession>
    <name>W4K811_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_419117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547869.1">
        <property type="nucleotide sequence ID" value="XM_009549574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K811"/>
    <dbReference type="GeneID" id="20673529"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_419117"/>
    <dbReference type="eggNOG" id="ENOG502SMYG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096875_0_0_1"/>
    <dbReference type="InParanoid" id="W4K811"/>
    <dbReference type="OrthoDB" id="3242031at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046528">
        <property type="entry name" value="DUF6593"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20236">
        <property type="entry name" value="DUF6593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6593" evidence="1">
        <location>
            <begin position="60"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="184" mass="20744" checksum="9AC3298AEDD1131A" modified="2014-03-19" version="1">MLPTLGMPYFLEDKSGTLLGSEFVDVNDRMRLGFRCTLRDVHRTAYMIYDLTMPSQGAYSFPVATLDYGANNALGTVIFSGRGSMPMSQYLSKMSPFGSSKNRKFIASDGQEYRWSWRGRENFEWMCLNASGYLVAYYNLKLAGEPPYPGSSGCMLTVDESYPHLAVELLTSLLIMRHIAEHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8K5</accession>
    <name>W4K8K5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_44888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545795.1">
        <property type="nucleotide sequence ID" value="XM_009547500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8K5"/>
    <dbReference type="GeneID" id="20675893"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_44888"/>
    <dbReference type="HOGENOM" id="CLU_2711580_0_0_1"/>
    <dbReference type="InParanoid" id="W4K8K5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="73" mass="8562" checksum="E1502267851FAD4D" modified="2014-03-19" version="1" fragment="single">KKTLFELLYRYQPWAYPSVIGNTNVPITNTYLKALQYIRKEAQASLKIIVKAMQIQHDYSRIDLLSFKKGDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8M2</accession>
    <name>W4K8M2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AVL9/DENND6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_173094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">TC 32-1</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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            <end position="544"/>
        </location>
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        </location>
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        </location>
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        </location>
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        </source>
    </evidence>
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</entry>
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
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                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="395" mass="45071" checksum="DBC65B300F3F2FBB" modified="2014-03-19" version="1">MGSLLSSSANMDCAERDIGRTSSFSSILSIHPIYDGIYSRLSPGARIRFGRTCRLAYNSVQDFHSRAFNINHHLRRFFDDPIAFRNMQARLAMLISGSNALQFLDSTSYPGSDLDLYVWEDSAKEVGHWLMEHEGYSSAPSKRKANEYASISIFRFDNFTKDGPDGPLTVQVVATLISPLEAILNFHSTCVMNCIAFDAAYSLYPQATFEQRVSLCIASRNDRRAEFKKYRNRGWKLILITPPQEKKSRGAPFHGDVIRWVHDHHSWVVPLDTSELQPRPRLSPTSEYFAWDPVIYNSWKLVERLIPKIMGSFHMTSGAPIGYRARGSVMRYEYLVMDSGLYQTIASFLEHQIHKRSNAERRSSAKQKELSTWCDATIGRLIDAHRAKEIQNQGN</sequence>
</entry>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Velez H."/>
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                <person name="Yakovlev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="10"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="345" mass="37606" checksum="39A10C48E332209A" modified="2014-03-19" version="1">MPSSGKPRTSILLTGPTGYIGGTILQHLLDHEDRATFDITVLVRDYLKAEKLHQFGITPVIGSLQDTEKLAQLASQADIVIHAANADDLPAVKAILSGLKEKHEQSDDAGILIHTSGTGFLVNLEGDTSIDPDIVYYDSKPEQLESLPVSRIHREVDLAIVAADTAGYIRAYIVCPSTIFNMASGPLVDSGIQNPHSVLIPWMIKNGIQRGQGGLLESGTNVWPLVDIDEVGDLYKLIFDAARADPLTPHGRAGYYFAENGEYVQYEICLEIAKALFEHGKGRSPEPVSLTDQEFKNFFGGSRLGALNCRARGERSRALGWRPKKGKAELLASVEPEIQVILAWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9G9</accession>
    <name>W4K9G9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">HETIRDRAFT_149134</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544792.1">
        <property type="nucleotide sequence ID" value="XM_009546497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9G9"/>
    <dbReference type="GeneID" id="20667322"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_149134"/>
    <dbReference type="HOGENOM" id="CLU_2574160_0_0_1"/>
    <dbReference type="InParanoid" id="W4K9G9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="81" mass="8207" checksum="14D74210ADBC805E" modified="2014-03-19" version="1">MSSTNSVVGTNPVGASGGGARSGRYSLGANAPAPVEGVNKATYKVGRAHVDLKGQTLAVGADEDRDGIYAEKGRCEQLVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9Q0</accession>
    <name>W4K9Q0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_426198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544927.1">
        <property type="nucleotide sequence ID" value="XM_009546632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9Q0"/>
    <dbReference type="GeneID" id="20674092"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_426198"/>
    <dbReference type="HOGENOM" id="CLU_1496402_0_0_1"/>
    <dbReference type="InParanoid" id="W4K9Q0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="180" mass="20682" checksum="1663C2AB70DE0435" modified="2014-03-19" version="1">MPKSKSPLDKDESGESNESISRLEIVKKMRRDTSPSSNEMRKLHLTLWFHLFAWFPVCAAKASLMSPITAERLFTETDSLSPRTPWHLLGCYYSSCPQRMTFSLLSSSRIYAQQRCYLFSQEVKVTGAGGDLESSEEEQADCQVAKSSWDIMHQSHPPILGMFSNVFELLWTLWQRRQPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAL3</accession>
    <name>W4KAL3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_315707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545135.1">
        <property type="nucleotide sequence ID" value="XM_009546840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAL3"/>
    <dbReference type="GeneID" id="20670249"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_315707"/>
    <dbReference type="HOGENOM" id="CLU_1258773_0_0_1"/>
    <dbReference type="InParanoid" id="W4KAL3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="220" mass="25085" checksum="BB4D71A83F33C8BB" modified="2014-03-19" version="1" fragment="single">PIAIQTTSEEQFNKKSARSHFNIMEDLFLIKKCHKESLQSLIHCVDESMHILKNLRDAGSNLKKQEKELTYMMFLWSLTSKFDSFDSFLSLMDVLSHSKLEDTFRHEDLNHVRHSGSIDSAQALIASFPLSLSSASTSYRHSRPPKKQYKCNFCIATGYTDDRCFNEELKKSKPHQAHSVQALKSLVPSSLDGWMTHLADSRVSMESSNKDCFGSGSWEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4KB43</accession>
    <name>W4KB43_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">U1 small nuclear ribonucleoprotein 70 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_157151</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545244.1">
        <property type="nucleotide sequence ID" value="XM_009546949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KB43"/>
    <dbReference type="FunCoup" id="W4KB43">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KB43"/>
    <dbReference type="GeneID" id="20667701"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_157151"/>
    <dbReference type="eggNOG" id="KOG0113">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045151_0_0_1"/>
    <dbReference type="InParanoid" id="W4KB43"/>
    <dbReference type="OrthoDB" id="4207594at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12236">
        <property type="entry name" value="RRM_snRNP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001585">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034143">
        <property type="entry name" value="snRNP70_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022023">
        <property type="entry name" value="U1snRNP70_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952:SF5">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12220">
        <property type="entry name" value="U1snRNP70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="113"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="198"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="223"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="323"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW82944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="386" mass="40511" checksum="E408E341CBA34A40" modified="2014-03-19" version="1">MPGTHLLPPNLLKLFAPRPPLTYARPLDKDIDRVVKKPVSPVGPLLVMLRESAALAEGEGMEEGEEPAFTHAEQTKRQIRKEERKKRRTEEFKIAKESYKPSEDAEAVGDPYKTLFISRLHKGASESDIRREFETYGTIERVRIVRDKKGRGRGYAFIVYERERDMKAAYKESDGLHIMGKRILVDVERGRTVRGWKPRRLGGGLGGRPKPVEQAAVSSSRGGFRGGFAGDRGGGRGGFSDRGGGFRGGRGGGFGGGRGGGGFGDRGGGGGFRGGGGGGFRGGRDDFGPPPRGGGFRGSRGSGIGFQGGGGFNDGPPPNRYGGPPGAGGPGGPGGYGPPGGGGGFGGGGPGYGPPSGRGDFGGGYRGDLKRESSGFDERDAKRPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KB47</accession>
    <name>W4KB47_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_382667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544941.1">
        <property type="nucleotide sequence ID" value="XM_009546646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KB47"/>
    <dbReference type="GeneID" id="20672131"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_382667"/>
    <dbReference type="HOGENOM" id="CLU_2498136_0_0_1"/>
    <dbReference type="InParanoid" id="W4KB47"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="86" mass="9881" checksum="27D376D4F00696BE" modified="2014-03-19" version="1">MYHGPDSWPGPLRYPSNIHIYICTVPTFTACHALRCPAHDDMYLRLRRHTTMQDTYTDTCEKTDETKRANTPAVHDCPTASTNNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4KB91</accession>
    <name>W4KB91_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_427372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546840.1">
        <property type="nucleotide sequence ID" value="XM_009548545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KB91"/>
    <dbReference type="GeneID" id="20674204"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_427372"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_0_0_1"/>
    <dbReference type="InParanoid" id="W4KB91"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="38"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="171"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="284" mass="31623" checksum="BE4EEB80F7F27FFC" modified="2014-03-19" version="1">MSRKLEWPTFSNAYHDELLGLVQSCASSQANHSCLTWKVVEAVHARSSFIFMQLFATGRAARPSGLTLDDPSFPYVGAGDISLADRNHERPRSMTVLEIKEYIQLFATAASNAVNEAGFDSVEIQGADGYLADQFLQTTANNRPDDMEDMRMLDPLPTFRSLVSRLRDTYPDLSCLHVVEPRIAGAAERESKVDESNDDLRKIWGSRPYLAAGGFTREDAIQTAEEKGGLVVFGRHFISNPDLPTRLLKGLPLTPYDRVMFYIQDGVKGYTEHPFSQVDIKVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBV9</accession>
    <name>W4KBV9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_106896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545610.1">
        <property type="nucleotide sequence ID" value="XM_009547315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBV9"/>
    <dbReference type="GeneID" id="20666198"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_106896"/>
    <dbReference type="HOGENOM" id="CLU_1917317_0_0_1"/>
    <dbReference type="InParanoid" id="W4KBV9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="132" mass="14282" checksum="05B5A72D597D32B0" modified="2014-03-19" version="1">MTRADLPSCPSAELGQQPDPPSLRPDSRPNATARPFTARVARGVSAGPSQRGPESARPPAPPANTHNLSSSTALDSITEEAALMMISAVREDGSIPCGRQGCYDILKDVKRWRYQVRPLPTAFHISLSYTHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KC78</accession>
    <name>W4KC78_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_107102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545245.1">
        <property type="nucleotide sequence ID" value="XM_009546950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KC78"/>
    <dbReference type="GeneID" id="20666214"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_107102"/>
    <dbReference type="HOGENOM" id="CLU_2151704_0_0_1"/>
    <dbReference type="InParanoid" id="W4KC78"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="112" mass="12545" checksum="57120ABF0FCEB6CB" modified="2014-03-19" version="1" fragment="single">MPRRSPPPARPAWLHSPPPRTMLAFNVCRRQHRRLASSARLLPRAPGRLRPVALTRLSSSTSARPLDFTSYFFHNEQWSADAMRPETHHPPSSPPALVPSSSHPYPSLPLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDQ6</accession>
    <name>W4KDQ6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_425463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543610.1">
        <property type="nucleotide sequence ID" value="XM_009545315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDQ6"/>
    <dbReference type="STRING" id="747525.W4KDQ6"/>
    <dbReference type="GeneID" id="20674034"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_425463"/>
    <dbReference type="HOGENOM" id="CLU_767389_0_0_1"/>
    <dbReference type="InParanoid" id="W4KDQ6"/>
    <dbReference type="OrthoDB" id="5576441at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="361" mass="38674" checksum="C7BCBF5D66FFA318" modified="2014-03-19" version="1">MTFGIRGKPRANGVQASVLASSTEADTIHCGLSPKYTNKHKAVAELPRLRPTSQSTSDNILSANPPSVPTSGDASDDSAEDFRAKLEHFAYTPVIQSSNFARSSPALSLANSIMTDLDSVTLPKSKRPRTTKPRLNVNVPGLDLAGLRKKSVAQKIIHIQSCAKKKGLTETTLKILLTQQLENAQNTQGKGKAKDVVDEVELAPKTYLEGVLEEAGTKKRKKRAKVVSTVQSLSQTSNAIRDRARLLFTNPQSLQPLQATQAFGPSKLGAALRHPLIDSEPPQTQAFGENGLAQGSSLTRFSSLGSASKRSEDEDDNAPAATQAFAPSRLATMFNGTAFHNDAGNKSVIDVRVVILCSPHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDR0</accession>
    <name>W4KDR0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_116407</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>fluoride(in) = fluoride(out)</text>
            <dbReference type="Rhea" id="RHEA:76159"/>
            <dbReference type="ChEBI" id="CHEBI:17051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:76160"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543614.1">
        <property type="nucleotide sequence ID" value="XM_009545319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDR0"/>
    <dbReference type="FunCoup" id="W4KDR0">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KDR0"/>
    <dbReference type="GeneID" id="20666517"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_116407"/>
    <dbReference type="eggNOG" id="ENOG502QT5F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030507_1_0_1"/>
    <dbReference type="InParanoid" id="W4KDR0"/>
    <dbReference type="OrthoDB" id="409792at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="FluC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259:SF1">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW83879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="397" mass="42819" checksum="86C8AD84FB5BD12C" modified="2014-03-19" version="1">MVNDLSSLEKGSSRFPFSIRNTTSESTPTEASLAAKPEEFPTRPSLTHRPTDVGSAIGHQEPVDDATSLASIGRPPSIVEKLPPAKVYHPLSPAVLALLMPASVFGALARLGLQALVTYDGQSIFSLAYIQAIGCLIMGIGLSVKEPLGNFYGPLYTALTTGFCGSFTTFSGWQLDVFNSWINEKHDHRDWLRDVTDGSTKLFFTLSISLASLNFGIHLASLIAPRIPSVRPPSRTIRYGVTALSVLIYFATYPAYFQLPDSFRHKATAALLFSFPGTLTRYFLSISLNPRFKLLPMGTLAANAFGTGLLAMFHVLQGLPDPVSPNACAVLQGLADGYCGCLTTVSTFAAEVYALKKRKAWTYVAVSLITGQLLMLVIMGPSFWAGNVSEQGSCQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFN0</accession>
    <name>W4KFN0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_35037</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543174.1">
        <property type="nucleotide sequence ID" value="XM_009544879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFN0"/>
    <dbReference type="FunCoup" id="W4KFN0">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KFN0"/>
    <dbReference type="GeneID" id="20671782"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_35037"/>
    <dbReference type="eggNOG" id="KOG2295">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009652_0_0_1"/>
    <dbReference type="InParanoid" id="W4KFN0"/>
    <dbReference type="OrthoDB" id="342064at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039727">
        <property type="entry name" value="SE/Ars2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007042">
        <property type="entry name" value="SERRATE/Ars2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021933">
        <property type="entry name" value="SERRATE/Ars2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165">
        <property type="entry name" value="ARSENITE-RESISTANCE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165:SF0">
        <property type="entry name" value="SERRATE RNA EFFECTOR MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04959">
        <property type="entry name" value="ARS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12066">
        <property type="entry name" value="SERRATE_Ars2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="674"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="63"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="591"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="721"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="819"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="832"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW84534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="909" mass="102689" checksum="BA93D819D5C2E466" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4KG17</accession>
    <name>W4KG17_HETIT</name>
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        <recommendedName>
            <fullName evidence="2">DUF6697 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_314235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544407.1">
        <property type="nucleotide sequence ID" value="XM_009546112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KG17"/>
    <dbReference type="STRING" id="747525.W4KG17"/>
    <dbReference type="GeneID" id="20670106"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_314235"/>
    <dbReference type="eggNOG" id="ENOG502SSGT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046159_0_0_1"/>
    <dbReference type="InParanoid" id="W4KG17"/>
    <dbReference type="OrthoDB" id="3176940at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046520">
        <property type="entry name" value="DUF6697"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20411">
        <property type="entry name" value="DUF6697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6697" evidence="2">
        <location>
            <begin position="38"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW84778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="296" mass="33590" checksum="4537AFD52665A19F" modified="2014-03-19" version="1" fragment="single">KLKEDMSLDEATVRSRIAAVGAEPWPVIMDITVASVSVTRLFMSTEYGGSPVAVFPSIAEARFKVHGYKDFMFMSVKWHPNAPSRPGEPGLWYNPTPLADTWMEDKGAVQRLFVGLDQSKWMYFGQYKLAPAPSLTQTEWVLQSPKVKNTWGREIQSKSWGKQVRVEVILRRELGREPTRTEVRDAYNSNDRYDNVTAEEIIKAYDEGKQNLGIATLKCVGYDEEFQRKLAQAFPTWVPPQSKSKKKGHAKKIRRSKGKTAANKDEIFSDGNEEDDDVQIIEGPYVKKGTRSRPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGG0</accession>
    <name>W4KGG0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_157976</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544548.1">
        <property type="nucleotide sequence ID" value="XM_009546253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGG0"/>
    <dbReference type="GeneID" id="20667763"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_157976"/>
    <dbReference type="eggNOG" id="KOG2262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004965_3_0_1"/>
    <dbReference type="InParanoid" id="W4KGG0"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
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    </evidence>
    <sequence length="775" mass="86409" checksum="3CD265E891353786" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGL5</accession>
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        </lineage>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
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                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
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</entry>
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        </lineage>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
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                <person name="Stahlberg J."/>
                <person name="Velez H."/>
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                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <end position="382"/>
        </location>
    </feature>
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            <end position="366"/>
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    </feature>
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            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01124"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW85004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="407" mass="45516" checksum="8874F690D8A25C2F" modified="2014-03-19" version="1">MAVPDKYKQLGEFYKYYTGEMTAPVLTIIIGGNHEASNYLWELYHGGWLAPNIYFLGHAGCLQVNGIRIAGASGIFKSQDFHQGHLERLPYTASSMRSIYHIREYNVRRLSLLSSPHIFLSHDWPQGIEHHGDTRGLIRRKPFFRRDIDTGNLGSPPLMHLLRTLKPAWWFAAHLHVRFEALFTHDAGPSLNNEPPPATVHNPDEIVIEDIDEPDAAPSTEAVVVEKDASEPVSQSAPRINPDEILLDDEEEQIIDVESDPEFGETSPPILSYDPEWLAITRAFQPFFSLTRHQPPFPKEAQAWAMIEKELEWVKQNVGKKLAADDAHVSRPAFWRVDSCQKFAMTAPGPGQEGGPKHQQPPLYANPQTDAFADMLEIENKIAPRAAQSSRLAAGPSTTQAAARSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KH22</accession>
    <name>W4KH22_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_448364</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542037.1">
        <property type="nucleotide sequence ID" value="XM_009543742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KH22"/>
    <dbReference type="GeneID" id="20675850"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_448364"/>
    <dbReference type="HOGENOM" id="CLU_616853_0_0_1"/>
    <dbReference type="InParanoid" id="W4KH22"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="444" mass="48731" checksum="F660FA96EE41368F" modified="2014-03-19" version="1">MHRTLPAEAPGSPPRPASPRPSGPSSIPASFTTLRQILPNAIAIAIAKSKSKIKIQIRKKTQKNKRRRRPRRSHAPPISNTAIDSPLRSSPMTCPGPLRVVHVRALTRPPRIHYLIQVPAQPSPYLRRSARTAPARPSFPFAFRLRTFSCGLPAADFQLPAVDSQLRTTSFGRQAVRHLSTYLWRSSSCAGAIRYDTIRYDTMQLDTATIQRDTPRYDTTRLDLTRRRYETIQYDSTRLDTTQRDTTRHTPRRPAARCPMPPAPCRLPRAVLYNCYNHKHHPTPDPTITYSRTHTSTQIQPRSAIQRRTGAPAPDGASNVGPSPVREHFESCAGRFPETRALEGTCYRGYMLSRGHALEGPSSVSAPSRSAARVRRPAPRAPPSPARPSTLNLRSCLCAPPTLDAQRQPLQAAAHRIALRIRSTDDDGGGGGGGGGGGGGGGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHL4</accession>
    <name>W4KHL4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_310169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542188.1">
        <property type="nucleotide sequence ID" value="XM_009543893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHL4"/>
    <dbReference type="GeneID" id="20669756"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_310169"/>
    <dbReference type="HOGENOM" id="CLU_050560_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHL4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="479" mass="52735" checksum="A5779419CFFA55C8" modified="2014-03-19" version="1">MLLHDDHDASSPSRNSSPDVVLMVANLDVERVERGTSPHRPDAGRIDRGTSPQQPGSTGVLLTPHINNFSDDDAEDYAKFKERERTRRPSPERASRDAPRHESSDDRNQSSLGQLPVGVPPPSEGTPNSGVAGPLGFRARTAAQLPSHGEAEPIPVLSETASPPVPTGGPIPSSMGGPTPRADPHAGELERHADALLQWNTISAVIQMATAMALQRLANFSAGQPGNEHSDVPRRLASASLQIRTLALQTDPDTASWYAHNDGRPRALLIHPDEFSQYVNRELLPALLFGGELGNVQPSRTDPFRVVTWNVPRPGEHTTPVPNLRRVPRTVVEHPPPRQREVSTAHSHTATPPSHRIRGFPLSQGNTDEEEPPVYRRNEGRRSRGSQTTLGRGTTAGRSVRHRPRSPPPSARLRTHKREDNRSSRRTRRTDSEARRNSSWTRSKLDAWDALDDPGNYDEADPYYRPDEGGGDYQGPFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHM5</accession>
    <name>W4KHM5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_313998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544429.1">
        <property type="nucleotide sequence ID" value="XM_009546134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHM5"/>
    <dbReference type="GeneID" id="20670079"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_313998"/>
    <dbReference type="HOGENOM" id="CLU_2794247_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHM5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW84800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="68" mass="7252" checksum="9C13DD4D3168F3BB" modified="2014-03-19" version="1">MIAVVCVDAVEVKMSSGKVVVIVIEFAEEVVCARVVGLNTICGCSVPVGFISDTLELRLWTGLLHGFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIF6</accession>
    <name>W4KIF6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PNK3P-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_470728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542474.1">
        <property type="nucleotide sequence ID" value="XM_009544179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIF6"/>
    <dbReference type="FunCoup" id="W4KIF6">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KIF6"/>
    <dbReference type="GeneID" id="20677360"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_470728"/>
    <dbReference type="eggNOG" id="KOG2134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014938_3_1_1"/>
    <dbReference type="InParanoid" id="W4KIF6"/>
    <dbReference type="OrthoDB" id="19045at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000737">
        <property type="entry name" value="Bifunctional polynucleotide phosphatase/kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006551">
        <property type="entry name" value="Polynucleotide_phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01664">
        <property type="entry name" value="DNA-3'-Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="49030" checksum="45B14001F999BCE9" modified="2014-03-19" version="1">MASSSKLSTNLSNSKKRPLSRDALVESETPQKIVKVFPIFAKQSQPSSTASFQWLAPLGPKRTCLHGVNLSPRASTTVAAFDLDGTLLQSHIFKKKKSPSEWKWWKDVVPKKLKEVHNSGSAVVLISNQAIRSSQLEEWKKKISLVASALPDVPFRLLAATAKDGYRKPMPGMWYELERVFKAEGVEIDKATSFYVGDAAGRPNDFASTDRKFALNVELPFHTPEAYFLNLSEASYKLPGFNVSSLESVPRILPVGTSIIPATAASFPEIVLFVGFPCIGKSSFYRQHFRTAGYAHINQDTLGSRPKCLKAVDEAIRAGKSCVIDNTNRDVQTRRHYIELARKSDVRIRCFYFRGSVELAWHNNLYRAFNLPASIALHEPHRDFLPYMAFSSFAEKFEEPKESEGFLEVITVNWLFEGSKNEQRNWSMWLQIDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIN3</accession>
    <name>W4KIN3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_243966</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the GAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542416.1">
        <property type="nucleotide sequence ID" value="XM_009544121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIN3"/>
    <dbReference type="STRING" id="747525.W4KIN3"/>
    <dbReference type="GeneID" id="20669020"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_243966"/>
    <dbReference type="eggNOG" id="KOG3262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080002_2_1_1"/>
    <dbReference type="InParanoid" id="W4KIN3"/>
    <dbReference type="OrthoDB" id="2187159at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW85569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="94" mass="10309" checksum="7B4C958F2A0AF72E" modified="2014-03-19" version="1" fragment="single">EMGSFIHAVEDEMLCSSLIADKVPYFNAPIYLQNKSVIGKVDEILGPINEVYFSVKMGDGMVASSFKKGDKVYIAGDKLLPIERFLPKPKIVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJE2</accession>
    <name>W4KJE2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_308530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542773.1">
        <property type="nucleotide sequence ID" value="XM_009544478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJE2"/>
    <dbReference type="STRING" id="747525.W4KJE2"/>
    <dbReference type="GeneID" id="20669595"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_308530"/>
    <dbReference type="eggNOG" id="ENOG502S2RF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150163_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJE2"/>
    <dbReference type="OrthoDB" id="3253553at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW85978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="133" mass="14955" checksum="C9DAF3884D78BFBA" modified="2014-03-19" version="1">MFGQGQRPLDHEEDILSGDENSSAVSGVNRAPGTRPKRRSVFEGLAMEEQWRQARKELKWSLFFDLLGLGLWGVEFVWILIGPRCPLGEYDGWCTAFNLASACTCLLCVTFGISVFFDIKDLYASKSSPRTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJM0</accession>
    <name>W4KJM0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase active site lid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_154599</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542127.1">
        <property type="nucleotide sequence ID" value="XM_009543832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJM0"/>
    <dbReference type="FunCoup" id="W4KJM0">
        <property type="interactions" value="538"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KJM0"/>
    <dbReference type="GeneID" id="20667507"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_154599"/>
    <dbReference type="eggNOG" id="KOG3078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032354_1_0_1"/>
    <dbReference type="InParanoid" id="W4KJM0"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036193">
        <property type="entry name" value="ADK_active_lid_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57774">
        <property type="entry name" value="Microbial and mitochondrial ADK, insert 'zinc finger' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="6">
        <location>
            <begin position="150"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW85256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="240" mass="26749" checksum="0256A6A8382B3E76" modified="2014-03-19" version="1">MCDLQSLVAQLNQKISTLEAKTKAAAPSRTPASQLRTILIGPPGAGKGTQAPRIHDQFCQVNQKTKLGVEAKKIMDAGGLVSDDIMVGIIKDQLENNEACKNGFVLDGFPRTVPQAEKLDSMLFERKEKLDSVVQLEIPDELLISRITGRLIHPASGRTYHREFHPPKKAMTDDVTGEPIIQRSDDNIETLTKRLKSFHSQTTPVVQYYKNKGLWHRIDAAQSPSVVWDNLRKVFTAKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJR6</accession>
    <name>W4KJR6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_432596</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542882.1">
        <property type="nucleotide sequence ID" value="XM_009544587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJR6"/>
    <dbReference type="STRING" id="747525.W4KJR6"/>
    <dbReference type="GeneID" id="20674619"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_432596"/>
    <dbReference type="eggNOG" id="ENOG502QSCH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_395930_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJR6"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF87">
        <property type="entry name" value="COL-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW86108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="799" mass="90732" checksum="F1C29DC8F2BB5E50" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJT9</accession>
    <name>W4KJT9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_311418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542766.1">
        <property type="nucleotide sequence ID" value="XM_009544471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJT9"/>
    <dbReference type="GeneID" id="20669869"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_311418"/>
    <dbReference type="HOGENOM" id="CLU_2085127_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJT9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="117" mass="13085" checksum="5531061A207A12CA" modified="2014-03-19" version="1">MPQTPTLPGQLVPPNSVQGSWLKGHVAQLCGLNHDRYASECLWAVIYPTPRNADLCKFSQLSRQSARELRLKGSRATGKTRLLGLRKVRWHPSVARDIDKSGNERAAGSHYRSPQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJW6</accession>
    <name>W4KJW6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_379636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542460.1">
        <property type="nucleotide sequence ID" value="XM_009544165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJW6"/>
    <dbReference type="STRING" id="747525.W4KJW6"/>
    <dbReference type="GeneID" id="20671977"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_379636"/>
    <dbReference type="eggNOG" id="KOG1550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_126_3_1"/>
    <dbReference type="InParanoid" id="W4KJW6"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF3">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW85620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="48910" checksum="ECC46241C11BE321" modified="2014-03-19" version="1">MGPPTQVLYSQDIATSQFIQPSNPTSSASTIRSLDEAEFEERSPLYRTGTTASATLRTQKTKAVDLRAPPYTKEYIDNYRQRIKADPDPEAHFAYGKYLIDAAKKIGADAKDQRAVRKFRDTLIQESLKVMRRLATQGQPYDEAQFFLANCYGTGMLGLQVDHEKAYHLYLQAAKQNHAAATYRVAVCNEIGAGTRKEPPRAAAFYRKAASLGDTAAMYKLGMILLQGSLGEAKNPREAIGWLRRAAEQADEENPHALHELALLHEIPNGQFIPHEPLQSKELYTRAAYLGYTQSQYKLGQCYEYGALGCPVDPRRSIAWYTKAAEKGNSEAELALSGWYLTGSDGVLVQSDSEAYLWARRAANKGLSKAEYAVGYYAEVGIGIKQDVEFAKRWYMRAAAQGNKRAMNRLTEMKRQGSKRANMARPTRQQAKDECVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJX1</accession>
    <name>W4KJX1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="2 8">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_154209</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="8">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="2 8"/>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542931.1">
        <property type="nucleotide sequence ID" value="XM_009544636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJX1"/>
    <dbReference type="STRING" id="747525.W4KJX1"/>
    <dbReference type="GeneID" id="20667478"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_154209"/>
    <dbReference type="eggNOG" id="KOG4749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033188_1_0_1"/>
    <dbReference type="InParanoid" id="W4KJX1"/>
    <dbReference type="OrthoDB" id="272370at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.110">
        <property type="entry name" value="Inositol-pentakisphosphate 2-kinase, N-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043001">
        <property type="entry name" value="IP5_2-K_N_lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW86163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="433" mass="48021" checksum="F03EFD5FE1D21988" modified="2014-03-19" version="1">MSGFNETSPSDWKYVSEGGATIVFSYRGPTHPGFGFDNTVLRLRKQRLHKLAAKRGKSSDDIDDADLDDPMIEFQQKIVGRLISSEFLVRLRVAHLESPWLEQFASYHEPSRPAERKQVDTIDLSKRKAVLATDLVGGEACVVEIKPKWGFLPFPAHLSPQSALIKTRTCRTCMHNHLRHIKGEPAALSYCPLDLFSGTEARTARAIHGLWDAWKDSRGSVNNLRIFSQGQLLKPDDEEGVAEWAQTVFGSSDLADDDLRAKFTAALLSIVLETPLLRHLSKIQRTLDALDSEGLSKLRAQAAASSFSSNHDVDSPISGRGTDLSEPSIGDWTAFVDAYLASHDARDHSKPLPSELRYYTLAYLLSATFKDCSVLVKLPPTRDAHPAAQGLVKVIDLDPKSVKKMPGWEELDQQIMGSYAAVIEDLRRTCQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJY4</accession>
    <name>W4KJY4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_457655</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
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        <property type="protein sequence ID" value="ETW86162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542930.1">
        <property type="nucleotide sequence ID" value="XM_009544635.1"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KJY4"/>
    <dbReference type="GeneID" id="20676853"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_457655"/>
    <dbReference type="eggNOG" id="KOG0243">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0244">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001982_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJY4"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="16"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="264"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="870"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="927"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1033"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1737"/>
            <end position="1841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1948"/>
            <end position="1981"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="583"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="709"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1100"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1229"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1394"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1547"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1644"/>
            <end position="1737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="928"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="987"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1038"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1062"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1759"/>
            <end position="1771"/>
        </location>
    </feature>
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        </location>
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        <location>
            <begin position="1801"/>
            <end position="1820"/>
        </location>
    </feature>
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        <location>
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        </location>
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            <end position="1973"/>
        </location>
    </feature>
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        <location>
            <begin position="123"/>
            <end position="130"/>
        </location>
        <ligand>
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        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW86162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1981" mass="218939" checksum="B1F25F8B4732AA2F" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJZ2</accession>
    <name>W4KJZ2_HETIT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_414387</name>
    </gene>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">TC 32-1</strain>
        </source>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KK89</accession>
    <name>W4KK89_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_100229</name>
    </gene>
    <organism evidence="1 2">
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_100229"/>
    <dbReference type="HOGENOM" id="CLU_2705090_0_0_1"/>
    <dbReference type="InParanoid" id="W4KK89"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="73" mass="8079" checksum="F0C01DE0BB6FF0F2" modified="2014-03-19" version="1">MDIFSIGTPGSIEIVEKARPDNPRHTPARCTDRTRLRGNARWEDGRMLSGRLWGLTLPHTVIAGEAASPALER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4KL41</accession>
    <name>W4KL41_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="2">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_13944</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="2"/>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541715.1">
        <property type="nucleotide sequence ID" value="XM_009543420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KL41"/>
    <dbReference type="STRING" id="747525.W4KL41"/>
    <dbReference type="GeneID" id="20666997"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_13944"/>
    <dbReference type="eggNOG" id="KOG2875">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027543_3_2_1"/>
    <dbReference type="InParanoid" id="W4KL41"/>
    <dbReference type="OrthoDB" id="238681at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="10">
        <location>
            <begin position="65"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW86075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="268" mass="30541" checksum="94E1BD5F1D555BBB" modified="2014-03-19" version="1" fragment="single">PSQESEREAETLLWLKDYFQLDVDLLKLYNEWSERDAVFMRFRRRFEGIRMLRQDPWENLVSFICSSNNNITRITKMVKSLCEKYSPPLLSMPPPLALESFHPFPPPSRLAATDVSATLRSLGFGYRAEYIQKTAKMLVNQHEGSSNSSDAQEAAELWLISLRKMPTSQVRAELLKFMGVGRKVADCVLLMSMDKKEVIPVDTHVHQIAMKHYDVRGANSRRGASATKQALSAKLYEEVSLKLMGVWGDYAGWAHSVLFTADLRSFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4KL88</accession>
    <name>W4KL88_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS monocarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_40425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540305.1">
        <property type="nucleotide sequence ID" value="XM_009542010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KL88"/>
    <dbReference type="GeneID" id="20672513"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_40425"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_3_1"/>
    <dbReference type="InParanoid" id="W4KL88"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW86592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="283" mass="30500" checksum="59B0BB8139A71E51" modified="2014-03-19" version="1">MERPVLGAWLIQFCTMGVTLSYGIFQDFYTTTQLNNHSPAVISVIGGTQIFLTFALGPVSGRLFDSCYTRTAFTSGSLLYVLSFLMLSFVEPSQWSQAFLAQGVGMGLGAGLLCLPSYAVAAEHFKSRRGLITGIVQSGSAFGGVVFSIILNHLFRGPFAVGFGWGTRDTTLIVMNLLILGNLLIFVPPRPPLLSPSSPSVATIRDTPFLITLAWAFVTLIGLYFPLFYIQTFARMNGPYNLAFYSPAILNAAGILGCLLPHLAANQIGTLRVLVPVTIISGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLE6</accession>
    <name>W4KLE6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_241641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540536.1">
        <property type="nucleotide sequence ID" value="XM_009542241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLE6"/>
    <dbReference type="GeneID" id="20668898"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_241641"/>
    <dbReference type="HOGENOM" id="CLU_096303_0_0_1"/>
    <dbReference type="InParanoid" id="W4KLE6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="243" mass="27134" checksum="7CCAB9A3AEDF5350" modified="2014-03-19" version="1" fragment="single">PPNEGVVEVWMPALAPLDDDEDDLYMTPPPETAHNENTNDSEDEDDLYMTPPPENLNGHVENQEAVEEAAHVDVTMTRTPPRTPEHERQTVREQERAERLQMTSPTLRRERSALRGSIRQPVFEDLSRPSHPATSNSAQPPISLAPPIQLHQPATLAPPVQSYHSTVAASSAPSYHPAQYVPPHFYPAPMFQHSVYHGAMAYQIPGQYPIYAPPPMPAPPPHYWPVNVSAHPNLPRHLIGNHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLG3</accession>
    <name>W4KLG3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Transcription elongation factor Spt6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_181242</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SPT6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542691.1">
        <property type="nucleotide sequence ID" value="XM_009544396.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="W4KLG3">
        <property type="interactions" value="843"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KLG3"/>
    <dbReference type="GeneID" id="20668599"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_181242"/>
    <dbReference type="eggNOG" id="KOG1856">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001680_0_1_1"/>
    <dbReference type="InParanoid" id="W4KLG3"/>
    <dbReference type="OrthoDB" id="995477at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02065">
        <property type="entry name" value="B12-binding_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09928">
        <property type="entry name" value="SH2_Cterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09918">
        <property type="entry name" value="SH2_Nterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2740:FF:000002">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.850:FF:000001">
        <property type="entry name" value="Transcription elongation factor spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000056">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2740">
        <property type="entry name" value="Spt6, Death-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.850">
        <property type="entry name" value="Spt6, helix-hairpin-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049540">
        <property type="entry name" value="Spt6-like_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028083">
        <property type="entry name" value="Spt6_acidic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042066">
        <property type="entry name" value="Spt6_death-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032706">
        <property type="entry name" value="Spt6_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028088">
        <property type="entry name" value="Spt6_HTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035420">
        <property type="entry name" value="Spt6_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035018">
        <property type="entry name" value="Spt6_SH2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035019">
        <property type="entry name" value="Spt6_SH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028231">
        <property type="entry name" value="Spt6_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055179">
        <property type="entry name" value="Tex-like_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017072">
        <property type="entry name" value="TF_Spt6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145:SF6">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14635">
        <property type="entry name" value="HHH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14641">
        <property type="entry name" value="HTH_44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14633">
        <property type="entry name" value="SH2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14632">
        <property type="entry name" value="SPT6_acidic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21710">
        <property type="entry name" value="Spt6_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22706">
        <property type="entry name" value="Tex_central_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14639">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036947">
        <property type="entry name" value="Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="1131"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW85881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1566" mass="178237" checksum="7A781837C6F603AF" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4KM00</accession>
    <name>W4KM00_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_40718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540314.1">
        <property type="nucleotide sequence ID" value="XM_009542019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KM00"/>
    <dbReference type="STRING" id="747525.W4KM00"/>
    <dbReference type="GeneID" id="20672577"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_40718"/>
    <dbReference type="eggNOG" id="ENOG502SC55">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101498_0_0_1"/>
    <dbReference type="InParanoid" id="W4KM00"/>
    <dbReference type="OrthoDB" id="5551751at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040200">
        <property type="entry name" value="Mug57-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156:SF1">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="12"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW86744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="167" mass="18471" checksum="E294920305572FF5" modified="2014-03-19" version="1">MSEIVESLQHAQPTLADLLTIERSASIFFSYARETGLNSLFSDETAMNTILVPTNKAVMALAKKPHQDPSPVEHGIEISEQEFDSRSKKNVEKWVSLHIIPESPISLLGHTYPTLIEGKYVTFTEVDDGATAPEWARVLLNGDVRILEMKEASNGVLYLIDGTVSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4KM31</accession>
    <name>W4KM31_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_377542</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540861.1">
        <property type="nucleotide sequence ID" value="XM_009542566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KM31"/>
    <dbReference type="FunCoup" id="W4KM31">
        <property type="interactions" value="272"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KM31"/>
    <dbReference type="GeneID" id="20671885"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_377542"/>
    <dbReference type="eggNOG" id="KOG0663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="W4KM31"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07843">
        <property type="entry name" value="STKc_CDC2L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000211">
        <property type="entry name" value="Cyclin-dependent kinase G-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045267">
        <property type="entry name" value="CDK11/PITSLRE_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="84"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="377"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW86893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="418" mass="47028" checksum="43792FAA8479DEE4" modified="2014-03-19" version="1">MSSSPTPLRKRSKWDEDDQDNEAVVRQPILKRKAKPKAVSSESQTPSRTESPSSQSRPRSNHSLFVPPRTYHPPFIPSRSVYCYERLNSIEEGSYGVVFRAKEKQTGDIVALKKLKLDEEKHGFPITALREINALMTCRHENVVGIREVVVGDTLTQVFIVMDFIEHDLKTLLTLMPSPFLQSEIKTLMIQLLSAVAHCHSMWILHRDLKTSNLLMNNRGTIKVADFGLARRYGDPIGVGGLTQLVVTLWYRAPEILLGAKSYSTAVDMWSVGCIFAELLLKEPLFQAKGEIELLSMIFKLLGPPTNNSWPEYSSLPLAKTITLPSPQPHQLRQRFQYMTTAGIDLLMSLLTYDPERRISAEEALQHPYFTESPLPKHPDLFGSFPSAAAGERRRKPFDSPTAPARAADQLLSNLDPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMM1</accession>
    <name>W4KMM1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HETIRDRAFT_468888</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the second and fifth step in the 'de novo' purine biosynthesis pathway; contains phosphoribosylamine--glycine ligase (GARS) and phosphoribosylformylglycinamidine cyclo-ligase (AIRS) activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">In the C-terminal section; belongs to the AIR synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the GARS family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541036.1">
        <property type="nucleotide sequence ID" value="XM_009542741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMM1"/>
    <dbReference type="FunCoup" id="W4KMM1">
        <property type="interactions" value="645"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KMM1"/>
    <dbReference type="GeneID" id="20677260"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_468888"/>
    <dbReference type="eggNOG" id="KOG0237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005361_1_0_1"/>
    <dbReference type="InParanoid" id="W4KMM1"/>
    <dbReference type="OrthoDB" id="2018833at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000006">
        <property type="entry name" value="Phosphoribosylamine--glycine ligase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000006">
        <property type="entry name" value="phosphoribosylamine--glycine ligase, chloroplastic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000001">
        <property type="entry name" value="Phosphoribosylformylglycinamidine cyclo-ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000018">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.600.10:FF:000001">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000019">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="entry name" value="Phosphoribosylglycinamide synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520:SF12">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01209">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="16">
        <location>
            <begin position="112"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETW87093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="781" mass="82377" checksum="25C444015D00D12C" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4KN10</accession>
    <name>W4KN10_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_468090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
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        <property type="protein sequence ID" value="ETW86426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009542156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KN10"/>
    <dbReference type="FunCoup" id="W4KN10">
        <property type="interactions" value="198"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KN10"/>
    <dbReference type="GeneID" id="20677210"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_468090"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_3_1"/>
    <dbReference type="InParanoid" id="W4KN10"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19120">
        <property type="entry name" value="AKR_AKR3C2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044494">
        <property type="entry name" value="AKR3C2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="8">
        <location>
            <begin position="24"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW86426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="311" mass="33849" checksum="0E7ADD9E1C650B9B" modified="2014-03-19" version="1">MSFPTIALNDGNKKIPAIAFGTGSKFFRQDVTQYVDQALESGFSHIDTAAVYGNEEFVGTAIRESGLDRSELYITTKYDGGDIQESIRSSLDKLDVKSVDLYLIHFPRLVEHDFEGTWRQIENIKEAGLAKSIGVSNFSLDDLKSVVKSARIKPAVNQIRFHPYNFSSYKDVLEYSAKHGIVTEAYGSLAPITQFPNGSLDPVLATISKRVGGTPAQVIFKWVLAKGAVIVTTSSKTERLQEYLAVADLSDLTPEEVAAIDEAGAKGAPASWRSLANVSVSFLLLLRIAVSLLFLGYVALASSKRSCSLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KN34</accession>
    <name>W4KN34_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_307848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541156.1">
        <property type="nucleotide sequence ID" value="XM_009542861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KN34"/>
    <dbReference type="GeneID" id="20669531"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_307848"/>
    <dbReference type="eggNOG" id="ENOG502SCVB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1547679_0_0_1"/>
    <dbReference type="InParanoid" id="W4KN34"/>
    <dbReference type="OrthoDB" id="2500246at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW87227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="169" mass="18216" checksum="DC2C57DC6C88D716" modified="2014-03-19" version="1">MSDFVQGLDPSRFVLAETVLSFAISPFAAPTYNLPIFLFGLYAQENTEAVLSLQVFSALLGASALFDLIWMFQNPQAWVIRMVSVLIFLFKAPTFLAFANSLRSRGHLTGLGGLGGACAVWTMPGGFSSNDRDGYQAVHEHSVPETARPPIASPQIHQAPPAPGAYQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNI7</accession>
    <name>W4KNI7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_41415</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540334.1">
        <property type="nucleotide sequence ID" value="XM_009542039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNI7"/>
    <dbReference type="FunCoup" id="W4KNI7">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KNI7"/>
    <dbReference type="GeneID" id="20673154"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_41415"/>
    <dbReference type="eggNOG" id="KOG1477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016552_2_0_1"/>
    <dbReference type="InParanoid" id="W4KNI7"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="6">
        <location>
            <begin position="127"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW87269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="350" mass="38730" checksum="00FD4FD1DF41FC34" modified="2014-03-19" version="1" fragment="single">MASTPPAALRDVLVRTVRYVDPVVVDDPRRREPSNDALLVLLPLLIVLSTFLFLLLLFLLCVILLRRRRGIALRDTDGPVDMSREDSIEGEGGFDGVESRWLESVSDVTRRSYLRAKEYQLQYQPNSLPTDITLSQFLSIQEKGVSAWSFDPDYEMMASLLVHARTELTFLPDPSSATSVQSNLPLPKLNEVYYWEVKMFDLPETTNVAVGLATKPYPSFRLPGHNRYSVAYHSNGDKSHNYPFTAATFGPALKEGDVLGVGYRPRSGTVFYTRNGRKMEDAFVGLNNWNLFPTIGADGPCSLHVNLGQAGFVFIEANVKKWGLAPSVGTLAPPPAYGSERGSILLEAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNT5</accession>
    <name>W4KNT5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_244958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541396.1">
        <property type="nucleotide sequence ID" value="XM_009543101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNT5"/>
    <dbReference type="STRING" id="747525.W4KNT5"/>
    <dbReference type="GeneID" id="20669072"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_244958"/>
    <dbReference type="eggNOG" id="ENOG502S5N7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002353_0_0_1"/>
    <dbReference type="InParanoid" id="W4KNT5"/>
    <dbReference type="OrthoDB" id="160374at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW87503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="986" mass="108811" checksum="B37A8F7AFA958990" modified="2014-03-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNZ4</accession>
    <name>W4KNZ4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial</fullName>
            <ecNumber evidence="10">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Succinyl-CoA synthetase beta chain</fullName>
            <shortName evidence="10">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_437981</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="10"/>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541424.1">
        <property type="nucleotide sequence ID" value="XM_009543129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNZ4"/>
    <dbReference type="FunCoup" id="W4KNZ4">
        <property type="interactions" value="354"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KNZ4"/>
    <dbReference type="GeneID" id="20675001"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_437981"/>
    <dbReference type="eggNOG" id="KOG2799">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037430_0_0_1"/>
    <dbReference type="InParanoid" id="W4KNZ4"/>
    <dbReference type="OrthoDB" id="1552at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000004">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001913">
        <property type="entry name" value="PRK00696.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF1">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp fold succinyl-CoA synthetase-type" evidence="13">
        <location>
            <begin position="25"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase/succinyl-CoA ligase C-terminal" evidence="12">
        <location>
            <begin position="292"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="75"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="351"/>
            <end position="353"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW87532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="417" mass="44740" checksum="BD1119566ACE4320" modified="2014-03-19" version="1">MLASLRKAGSFTRAVSAGQRRFLSIHEYQSVNLLNSYDIPTPKSIAAKTPQEAFEAARVFGKDGSVIKAQVLAGGRGKGKFDNGLQGGVHKVESPEQARDYASKMLGAKLITKQTGAGGRVCNAVMLAERRDPAHEYYVALLNDRVSQNVVLVASAQGGMNIEEVAAKDPDAIITTPIPLATGLSKESALEVANKLGFKTPEAKQEAADIFVNLYKIYKDKDATQIEINPLAETTDGHVLCMDAKFGFDDNAEFRQGDIFALRDISQEEPSEVEAQKANLNFIKLDGNIGCLVNGAGLAMATMDVLALHGGQPANFLDVGGGATPETVKKAFEILLSDPKVKSIFINIFGGIMRCDYIAEGVIKATKELSLKIPLVVRLKGTKETEAKEMIRQSGLKILPFDSLDEAAERAAQLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNZ5</accession>
    <name>W4KNZ5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol-phosphate mannosyltransferase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_307241</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540755.1">
        <property type="nucleotide sequence ID" value="XM_009542460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNZ5"/>
    <dbReference type="STRING" id="747525.W4KNZ5"/>
    <dbReference type="GeneID" id="20669471"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_307241"/>
    <dbReference type="eggNOG" id="KOG4841">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150782_1_1_1"/>
    <dbReference type="InParanoid" id="W4KNZ5"/>
    <dbReference type="OrthoDB" id="2014333at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013174">
        <property type="entry name" value="DPM3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433:SF0">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08285">
        <property type="entry name" value="DPM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW86766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="95" mass="10623" checksum="D85FCD00024AF6E9" modified="2014-03-19" version="1">MTRAGRVAIWSSVVLILYILAFLSYIPVPFVHQEVSDQVLLVLPWWLLVSFGSYSLGSLGHGLYTFQECTDAYTELLTEITQAKTELRAKGVSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4KP57</accession>
    <name>W4KP57_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_307739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541383.1">
        <property type="nucleotide sequence ID" value="XM_009543088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KP57"/>
    <dbReference type="FunCoup" id="W4KP57">
        <property type="interactions" value="375"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KP57"/>
    <dbReference type="GeneID" id="20669522"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_307739"/>
    <dbReference type="eggNOG" id="KOG1530">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089574_0_2_1"/>
    <dbReference type="InParanoid" id="W4KP57"/>
    <dbReference type="OrthoDB" id="566238at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01519">
        <property type="entry name" value="RHOD_HSP67B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF10">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="10"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="111" mass="12421" checksum="86CE4E39C2BEBB3F" modified="2014-03-19" version="1">MITLTLTRRSVQHAYLIDVREPDEVIQGNIPSSVNLPLSVLSGSLQLPATQFHKKHGFSKPGLDQEIVFYCRSGKRSATASDVAKRNGYTNIFNYKGSWLDWVEREGKPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPF7</accession>
    <name>W4KPF7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutamate--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_308400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="1"/>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541595.1">
        <property type="nucleotide sequence ID" value="XM_009543300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPF7"/>
    <dbReference type="FunCoup" id="W4KPF7">
        <property type="interactions" value="412"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KPF7"/>
    <dbReference type="GeneID" id="20669582"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_308400"/>
    <dbReference type="eggNOG" id="KOG1149">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015768_6_3_1"/>
    <dbReference type="InParanoid" id="W4KPF7"/>
    <dbReference type="OrthoDB" id="428822at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="entry name" value="Glutamyl-trna Synthetase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.800.10">
        <property type="entry name" value="Glutamyl-tRNA Synthetase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049940">
        <property type="entry name" value="GluQ/Sye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311:SF2">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="10">
        <location>
            <begin position="4"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="293"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW87728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="401" mass="44252" checksum="23DDA986AB0AF8CF" modified="2014-03-19" version="1">MQPVLLRFAPSPTGALHLGGLRTALFNHVFARKHGGRWILRIEDTDATRAVPGAVEGIREMLGWAGLEYDFGPGKHGPHGPYFQSERLDLYHFYAKKLLDSGHAYRCFCSPDHLAATRERLARAGMNTTYDKACLNLTEEEVARRVRAGEKSIVRLNVRPDSNLPRRTTPPDLIFGHLRDAHASLPTDPVLLKSDLFPTYHLASVVDDFEMGITHVLRGEEWLPSLPLHLDLYASLALDPPKFAHLPLLLNADGTKMSKRKGDVQVEDYMRRGWEPGAILNWLALAGWGVHSHAQPAPAPDSETPPPTSTPPPPPPPPPSPSASSSSPRTAAPDSTTILSLPEIIAQFDLAALTHRRTVLDPAKLEYINKHHLMRAWATDAGLQSLAERARPLVVSAFPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KQ83</accession>
    <name>W4KQ83_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ARM repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_469691</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLM10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541450.1">
        <property type="nucleotide sequence ID" value="XM_009543155.1"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KQ83"/>
    <dbReference type="GeneID" id="20677303"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_469691"/>
    <dbReference type="eggNOG" id="KOG1851">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000772_3_0_1"/>
    <dbReference type="InParanoid" id="W4KQ83"/>
    <dbReference type="OrthoDB" id="17907at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055455">
        <property type="entry name" value="HEAT_PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021843">
        <property type="entry name" value="PSME4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23096">
        <property type="entry name" value="HEAT_PSME4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11919">
        <property type="entry name" value="PSME4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="11">
        <location>
            <begin position="385"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4-like HEAT repeat-like" evidence="12">
        <location>
            <begin position="1362"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="1783"/>
            <end position="1821"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4 C-terminal" evidence="10">
        <location>
            <begin position="1848"/>
            <end position="1933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW87560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1933" mass="217566" checksum="03B06F6D87F684E9" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNB5</accession>
    <name>W4JNB5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_482815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW75052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553498.1">
        <property type="nucleotide sequence ID" value="XM_009555203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNB5"/>
    <dbReference type="STRING" id="747525.W4JNB5"/>
    <dbReference type="GeneID" id="20678056"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_482815"/>
    <dbReference type="eggNOG" id="KOG0805">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_6_0_1"/>
    <dbReference type="InParanoid" id="W4JNB5"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF14">
        <property type="entry name" value="ARYLACETONITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW75052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="353" mass="38518" checksum="4BB90106C307DA2F" modified="2014-03-19" version="1">MPVNLSPSNSDPRKFKVAAVQAEPVWLDLQGSVDKTIRLIRDAAAKGAKIIGLPEVFIPGYPWTPWCNDFVSCQPLLARYQANSLAVHSPEMDRIRAAVKELGVYVVLGFSERDGGSLYIAQATISETGEIINHRRKIKPTHYEKTIFGDGSAQSIHNVVQTPYGRLGSLNCWEQIQPALKLHFYSQLPQIFVGGWWPAFPAHTGGAPYIVSGEASARMTQAVSMEGGCFGLTACHVVSEEGAKIMMMDKYPWFKFPGGGFTTIYGPDGAALTAPIDPGVEETAIAEISLDMIGDIKIVADQMGNYSRHDLMHLVAHGKNWRPVEYADGEEQKGLEGRIADVANDSAFATPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4JP77</accession>
    <name>W4JP77_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_423498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553352.1">
        <property type="nucleotide sequence ID" value="XM_009555057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JP77"/>
    <dbReference type="STRING" id="747525.W4JP77"/>
    <dbReference type="GeneID" id="20673909"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_423498"/>
    <dbReference type="eggNOG" id="ENOG502SP5P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017203_0_0_1"/>
    <dbReference type="InParanoid" id="W4JP77"/>
    <dbReference type="OrthoDB" id="3515175at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW74885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="573" mass="63884" checksum="A02CF34224E39448" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPE3</accession>
    <name>W4JPE3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glyoxal oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glox4</name>
        <name evidence="7" type="ORF">HETIRDRAFT_56441</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552498.1">
        <property type="nucleotide sequence ID" value="XM_009554203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPE3"/>
    <dbReference type="STRING" id="747525.W4JPE3"/>
    <dbReference type="GeneID" id="20678360"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_56441"/>
    <dbReference type="eggNOG" id="ENOG502QPS4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009630_3_0_1"/>
    <dbReference type="InParanoid" id="W4JPE3"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF21">
        <property type="entry name" value="LOW QUALITY PROTEIN: ALDEHYDE OXIDASE GLOX-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004843729" evidence="4">
        <location>
            <begin position="20"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="659"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="Glyoxal oxidase N-terminal" evidence="5">
        <location>
            <begin position="132"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose oxidase-like Early set" evidence="6">
        <location>
            <begin position="494"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="612"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="712"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="625"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="719"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="738"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="777"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW75334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="787" mass="82067" checksum="175A8B123468A15E" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPK6</accession>
    <name>W4JPK6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_423174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552916.1">
        <property type="nucleotide sequence ID" value="XM_009554621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPK6"/>
    <dbReference type="GeneID" id="20673877"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_423174"/>
    <dbReference type="HOGENOM" id="CLU_3032621_0_0_1"/>
    <dbReference type="InParanoid" id="W4JPK6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW75507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="55" mass="6370" checksum="97B344D819B76017" modified="2014-03-19" version="1">MMRSSQSLDVHGKALRISKIIKFAAEQAPDQRSYFLLYRDQKISIHHPCVILESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRS1</accession>
    <name>W4JRS1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavodoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_481722</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WrbA family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552443.1">
        <property type="nucleotide sequence ID" value="XM_009554148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRS1"/>
    <dbReference type="FunCoup" id="W4JRS1">
        <property type="interactions" value="128"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JRS1"/>
    <dbReference type="GeneID" id="20677986"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_481722"/>
    <dbReference type="eggNOG" id="KOG3135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051402_0_1_1"/>
    <dbReference type="InParanoid" id="W4JRS1"/>
    <dbReference type="OrthoDB" id="504689at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="3">
        <location>
            <begin position="51"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW76238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="246" mass="25810" checksum="2F02D58374FDE4B9" modified="2014-03-19" version="1">MCFPSKKQANLLAEDSPASKPSTTPKPHPPKEQPAPPAATAPAVTMSSPKIAIVIYTMYGHIAKLAEAVKTGVESAGGAATIYQIAETLPEDILKKLYAAPKPAYPILAPADLPQFDAFLFGIPTRFGNFPAQWKTFWDATGQLWATGALYGKSAGLFVSTSSLGGGQESTAVAALSTLAHHGIAYVPLGYKNTFAQLSNLTEVHGGSPWGAGTLTAADGSRQPSALELEVATIQGKTFYEHVARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4JS17</accession>
    <name>W4JS17_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_119078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551941.1">
        <property type="nucleotide sequence ID" value="XM_009553646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JS17"/>
    <dbReference type="GeneID" id="20666625"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_119078"/>
    <dbReference type="eggNOG" id="ENOG502SPQF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047147_0_0_1"/>
    <dbReference type="InParanoid" id="W4JS17"/>
    <dbReference type="OrthoDB" id="3255924at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050972">
        <property type="entry name" value="SDr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403:SF14">
        <property type="entry name" value="OS05G0225800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403">
        <property type="entry name" value="TOL-PAL SYSTEM PROTEIN TOLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="494" mass="51796" checksum="095A569301D8A206" modified="2014-03-19" version="1">MAAFSWSDSVRALLSPCLACIRPPHPHPRPHPHSHSHPHDLEGLLADAASSSASASTSLYADADADADADADTMSLHSHLGARKKKKQRKAHGRRIRLFGWDLFGRPPIYLPDDEHEHEHEHDEHEHDVDDREEQRRSHRRRATLSSSTLDSDAAPLDPSAIEARLGEHAREAARRRREQEEHEERERGVREEREARRAERRERRAARRAAREGAGGGGAGLEGVGAFEGFQGSGGDAFDRARAGSVSRSNSHSNSHSNSHSHSNSHSHSHSHSHSHPTPNPEAPDADADDDANADFDARAYTRRAPAGPLSPDGTGTGGTGGTGSSSASSASRTGAAPRHYNHHYLSQPQPHPQPHPDPQLAAPAPAPARAHRPSRPSKSSKSSSSKKSTASSTSASASASASAPQSPSLASPVASHFPALGVGLVLEGDEEPAFEGFPNDMTGFPSARIGGGGAGAGGRGFPSVGFGAGGGRGGGGGGAKRDGGAFLANRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JS18</accession>
    <name>W4JS18_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_411796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551267.1">
        <property type="nucleotide sequence ID" value="XM_009552972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JS18"/>
    <dbReference type="STRING" id="747525.W4JS18"/>
    <dbReference type="GeneID" id="20672971"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_411796"/>
    <dbReference type="eggNOG" id="ENOG502RDEN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1797283_0_0_1"/>
    <dbReference type="InParanoid" id="W4JS18"/>
    <dbReference type="OrthoDB" id="3226064at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="132" mass="14268" checksum="CE5260181F9627E5" modified="2014-03-19" version="1">MRIIPLTLRITSYSAAPPEWPGRPTIHIEGGLAGQSNDLSDARRVHGKVEMVGNGDIRWSLCSEREDGDGEWQSEGVQLGGLGSATGVIGMWTGADHERMDPLGPFWAWKVGHADISDEATTVEVWEDLSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4JS38</accession>
    <name>W4JS38_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_53889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551863.1">
        <property type="nucleotide sequence ID" value="XM_009553568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JS38"/>
    <dbReference type="GeneID" id="20678279"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_53889"/>
    <dbReference type="eggNOG" id="ENOG502S5IV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033666_0_6_1"/>
    <dbReference type="InParanoid" id="W4JS38"/>
    <dbReference type="OrthoDB" id="2417635at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="60"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="177" mass="19655" checksum="BC8741CF7B77DD76" modified="2014-03-19" version="1" fragment="single">PTFKSGHKSIMVWGCIAHGVKGLLIKLEFLPATISEKGQRQGGGLGAKEYVAQVLEGPLKDFFDRMEQQQIHLMLVVKDGAPAHTSRLTKSAWLKLGITPLTHPPSLPDLNPIEPLWLLLKNCVADTPGASNSLENLWLAAQHAWEEIIEEEIQRHTGKMSERVAQVQAAKGWHTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4JT29</accession>
    <name>W4JT29_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_422633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552251.1">
        <property type="nucleotide sequence ID" value="XM_009553956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JT29"/>
    <dbReference type="GeneID" id="20673831"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_422633"/>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044999_1_0_1"/>
    <dbReference type="InParanoid" id="W4JT29"/>
    <dbReference type="OrthoDB" id="2898509at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="33783" checksum="52DA405712888FC8" modified="2014-03-19" version="1">MASLAASMNLTTAAKLTNPVAVFVGGTSGIGQGMAEAFNRHTKGNAHIILVGRNREAAEGIISKMRSAAGESRTGSYEFVPCDISLISNVKTATADIFAKHPKVNFLVLSAGNLSISRPETEEGLDKKLAVQYYSRWSFIHGLLPAMRAARDANEDAKVMSIFAAGYGGPIDVDDLGLKKRFNPAISGPCSTYNDLMCEEYALRNPGIAFAHAFPGFVRTNFLKASESILFRASNILLPLFYLFTVSQDECGEYLWKGLYRSAARAAGSAGVLGAYRIGSNGDNLGTKKYFGTPEQRKALWEHTCKETNTVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTE4</accession>
    <name>W4JTE4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_246187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551686.1">
        <property type="nucleotide sequence ID" value="XM_009553391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTE4"/>
    <dbReference type="STRING" id="747525.W4JTE4"/>
    <dbReference type="GeneID" id="20669105"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_246187"/>
    <dbReference type="eggNOG" id="ENOG502SQPF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1346029_0_0_1"/>
    <dbReference type="InParanoid" id="W4JTE4"/>
    <dbReference type="OrthoDB" id="3250555at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="204" mass="23528" checksum="684006140B1A9EB4" modified="2014-03-19" version="1" fragment="single">DLHDQFMNDPNTRFLAVYMFVRCFSALMEAEDIHASDMSASPESDMKSSALCQVDLEEGQRRIVWDHAVASIALSIKINRDTLPPLLPIYTRHYLVLAPHDMCYEDLELAQRDILEVFQYKLGFGSPQAFLDEIYLAMPTLRLLVGCKESWKIIENETWNCLFKAVREPDMARFPISVLTATALKQSIIQSLIWRFETEMQKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
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    <name>W4JTR6_HETIT</name>
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            <fullName evidence="2">HAMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_105960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551394.1">
        <property type="nucleotide sequence ID" value="XM_009553099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTR6"/>
    <dbReference type="GeneID" id="20666121"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_105960"/>
    <dbReference type="HOGENOM" id="CLU_569924_0_0_1"/>
    <dbReference type="InParanoid" id="W4JTR6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="255"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="428"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW76500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="479" mass="51296" checksum="128D86536DEAEE7F" modified="2014-03-19" version="1">MIPDFAAIITSISTTGIVHDTLVFWVEVKPLDGHAAGNPDSVKSVKDIADAIAVNSIIQVNKQALFSFRHFEGNIHYAFLMVGAYFTLLEYERPANLTPYVRPAGSLPTSPQKRARSDIRKNIHDDLGDPASIEPEVLYFNEPIFIDRVAGFSPLYLRALDAVAEASVGLFQDFRRPTVFGGPRAIAQPPGERSIGQDMVHSKLLGEQQRYAETQSPFTQNPPMLSVASTVSVFEPGAPNFPTVRSPPMTRSRVRAATEAALRATKEAERLAQSNLSADAVIGAAQEAGRLAQAVLEAVQEEENAQQAESKRSPFSSSSPWTVLSSPLAAESSPINLRGSARAHEYGSLLAPIDIPLDYRAPSTQTMGGIRDEDEPMSYAGASTESLLFNPSTPAIIDEDEPMPLARASTHPLFFPSTPSSSGDVNEGGSTSSAGLTSTSRGLAAPHVVLGSPFDAIPRLALPKDPPALKGSGKKKTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTU5</accession>
    <name>W4JTU5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_421768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551210.1">
        <property type="nucleotide sequence ID" value="XM_009552915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTU5"/>
    <dbReference type="GeneID" id="20673747"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_421768"/>
    <dbReference type="HOGENOM" id="CLU_1219820_0_0_1"/>
    <dbReference type="InParanoid" id="W4JTU5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="227" mass="25538" checksum="2209543A35FF30F8" modified="2014-03-19" version="1">MSPSTRLSKPIDYLLVDDHNKRREVRTVLVNANILDPKPMGSSKNSYAPLGATLELLTELVQEDMLKKWLINFDPDDILFYEPTDPIPTRTVRTRSMDEYRAMMNDGSLCQKQDEIREYIKAPGGGGRVVSFLVQVGRILEGPISSQHGSTESKRSTGLPGEEPWYWNRLVRLEEAVKRSGPPSKNAKASSYVKYQRGFARVIDGRSSIAGLDNRAPSIELYHPVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JV30</accession>
    <name>W4JV30_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_105469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550903.1">
        <property type="nucleotide sequence ID" value="XM_009552608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JV30"/>
    <dbReference type="GeneID" id="20666067"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_105469"/>
    <dbReference type="HOGENOM" id="CLU_1170775_0_0_1"/>
    <dbReference type="InParanoid" id="W4JV30"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="237" mass="24659" checksum="F80970787604A517" modified="2014-03-19" version="1">MPAACGATASATGSHDVHPFSTFSAPLSSNSSTHMLFSACAFDIRAEAPNQGHHPDHAQSRSKYTQLVEVSESIRGLHSKSGVRADSSQKENNCGSESGPSQTPRSHTALGVRTTSQAAPSARMVPAKRQNLATLSAAQDKDPPTAGHADYRIPGSADGLKLGLGRMISLNCPEPLSSSSPQHNPDWSLVSRGLAEPTPTPGPITSLKHATANTTLGAGERPPEPEIEATDRGGRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWI7</accession>
    <name>W4JWI7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Esterase/lipase/thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_67274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549679.1">
        <property type="nucleotide sequence ID" value="XM_009551384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWI7"/>
    <dbReference type="STRING" id="747525.W4JWI7"/>
    <dbReference type="GeneID" id="20678805"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_67274"/>
    <dbReference type="eggNOG" id="KOG4178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_20_1_1"/>
    <dbReference type="InParanoid" id="W4JWI7"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="72"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW77912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="351" mass="39500" checksum="830EE35785647A4F" modified="2014-03-19" version="1">MTDSELRQRTSTTGSTTPDVKKEVLEGLRTIFDPATCTRKGLCPVTKIRRQQEPLESHSLYFEQHGSGPEKVVFIMGLNSTSFSWAMQVNHFGRSPNHTILVFDNRGVGNSGRPRGPYSTSGMAEDVIVLLDYVGWTETRDLHVVGISLGGMIAQELSTRIPERIISLTLAVTTPGGLPWYNFPPWKGVASLGRLFLIADAENKLPILLDMVFPQEWLAQKAEDDPEGRTNREIQTGLYRHRLLMTRPQHPLGGLSQMYAGLLHHVDGSRLRKISSSIPKVLIVTGDKDHLVKPMNSRYLKQDMPEAELVVWEDTGHALHLQWVDRFNELLERVFREGKQRLADADGVWTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXJ7</accession>
    <name>W4JXJ7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6589 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_325386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550193.1">
        <property type="nucleotide sequence ID" value="XM_009551898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXJ7"/>
    <dbReference type="STRING" id="747525.W4JXJ7"/>
    <dbReference type="GeneID" id="20671146"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_325386"/>
    <dbReference type="eggNOG" id="ENOG502RAQF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009487_6_1_1"/>
    <dbReference type="InParanoid" id="W4JXJ7"/>
    <dbReference type="OrthoDB" id="4743193at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6589" evidence="2">
        <location>
            <begin position="2"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW78199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="417" mass="47929" checksum="42D1589746027FF3" modified="2014-03-19" version="1">MVVLFFGDLGTWERVNSLLEEQTIKKSPWHRYQFIVFIMGLFHLKMACADAIWRIFINPPDARQDPNSLLKLVGQLKPKETGKITSDPGFCRMHEVIGHTSICLHLDAWHVEVNKQLVLCSTLEEWAENKPSMEEIMDLSHTLARDYVAGLGSDHVDLSVLRHDRATRDQQRENILLMHQYMLLYEELMHAMNVGDVGHLETIFAPWIAILKACGKHKYASAITQFLLDVHFVYPEGLRCVVRYNVLVNPTGQPGKFRGVDWVIELNNLFTKHIYGGSGSNFTKDNVIKESCLIGVFQNCHKNVEENFQIPGLTTCKGHKDMKRTFNKLLKYTLDSEPNVSKAGRQARYYILDMIEKGLGLIEENEYKVGSDSYRETPGGQERENEDREHEMVDIEMDEEDLRVELQDHGMFSDDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXL1</accession>
    <name>W4JXL1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_326386</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550278.1">
        <property type="nucleotide sequence ID" value="XM_009551983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXL1"/>
    <dbReference type="STRING" id="747525.W4JXL1"/>
    <dbReference type="GeneID" id="20671236"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_326386"/>
    <dbReference type="eggNOG" id="KOG3022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024839_0_2_1"/>
    <dbReference type="InParanoid" id="W4JXL1"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001119">
        <property type="entry name" value="Iron-sulfur cluster carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961:SF2">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW78297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="36801" checksum="9B84DFEA74C7B98F" modified="2014-03-19" version="1">MPARLFSLSSALHHQNPLVRPRLHTPRTASLTCPAQGLPRAGAPAPPSLPRRGGPVAKRPIPHVKRVLVVASGKGGVGKSTVAVNLAFALAMRAGERRLRVGLLDLDIFGPSIPKLMGLDRADEPHLTPAGALVPLTNHGIPCMSMGFLLPKSTPAPGSSASAGSSADTPVVWRGLMVQKAVQQLLFDVDWRLGARTDASASGSESGSGTGTGLDVLVVDMPPGTGDVPLTLGQLVAVDGAVIVSTPQDVALADVRKGIAMFRKVGVPITGLLLNQSYFLCPSCDVRHDLFGSSDLFHATARQLGVPVLGELPLAPEVSGSGDAGAPYALLGGAGGGGGARWREGLEEVAERVWGSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXP4</accession>
    <name>W4JXP4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_388401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550316.1">
        <property type="nucleotide sequence ID" value="XM_009552021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXP4"/>
    <dbReference type="GeneID" id="20672368"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_388401"/>
    <dbReference type="HOGENOM" id="CLU_826557_0_0_1"/>
    <dbReference type="InParanoid" id="W4JXP4"/>
    <dbReference type="OrthoDB" id="3299832at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="336" mass="38030" checksum="CDEBB9FFC7049BCE" modified="2014-03-19" version="1">MRGDEADAVEELLRLASKIRADLEAPPMNTNIFNYGHDADTFHMMQPAVEIIPASVAGPSRQPTMAVLDTLITSQGEREAQAGKASACAEGEAHGETANAQAGGETEEKREKRCKPPGDGPWVCKVHNCEFRRWNELDRHMRSRKHEENAEEFHRPSLSHRCHRSDPQPSSPTTTAQTPNMSDRTPTQQSTPLPTDVPPAQPAKRDQARQRSHQPTTTIPPLWRPGRPLMLFGFLFTRDFLDWYCTVNKVGPIRTEQQRFTTDTVAFDKIRFDAKLRKSDCRTVYTGEDEPDDLALCLVIGTNYLEQDRKRPDEAIIQSVQAAMGVNMVPMWYRMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXW9</accession>
    <name>W4JXW9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_326023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550354.1">
        <property type="nucleotide sequence ID" value="XM_009552059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXW9"/>
    <dbReference type="GeneID" id="20671200"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_326023"/>
    <dbReference type="HOGENOM" id="CLU_2121389_0_0_1"/>
    <dbReference type="InParanoid" id="W4JXW9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="114" mass="13096" checksum="64D990118058B0F1" modified="2014-03-19" version="1">MEICEAPALKETDVEYLNPHQVHGHLQWARPISLKLFPSCIRRQRLVLQWSPTRQSSPLYLKALDELNSFTSWIPFDQSYGSTLTMSVLPNDEIFRCRTSTSTGLSQFLVNNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZL1</accession>
    <name>W4JZL1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_49713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548756.1">
        <property type="nucleotide sequence ID" value="XM_009550461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZL1"/>
    <dbReference type="GeneID" id="20678120"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_49713"/>
    <dbReference type="HOGENOM" id="CLU_000384_32_2_1"/>
    <dbReference type="InParanoid" id="W4JZL1"/>
    <dbReference type="OrthoDB" id="128646at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="82" mass="9558" checksum="4B707A3B0E320BBA" modified="2014-03-19" version="1" fragment="single">NINDTINKARLMYSGLNANLTVRDYQGSMHTEHVQMFITNLGKDNILLGTDWLKYHNPSIGWKHHEVHFDWCPQNCQQPHGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZY9</accession>
    <name>W4JZY9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_224201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ETW78655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009550679.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZY9"/>
    <dbReference type="GeneID" id="20668682"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_224201"/>
    <dbReference type="HOGENOM" id="CLU_2512909_0_0_1"/>
    <dbReference type="InParanoid" id="W4JZY9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="85" mass="9264" checksum="590EA3710F40340D" modified="2014-03-19" version="1" fragment="single">MDDTHSSGGRSKARKTYSGRAKAKKERVLQAYRVSFIHSRELRGLSAARESESDTNANEDEDAAAMPPPPSPQKETTSTKVNANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0G5</accession>
    <name>W4K0G5_HETIT</name>
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        <submittedName>
            <fullName evidence="7">GDP/GTP exchange-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_50012</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009550468.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="20678128"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_50012"/>
    <dbReference type="eggNOG" id="KOG4305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001251_1_0_1"/>
    <dbReference type="InParanoid" id="W4K0G5"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="252"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="477"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="703"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="891"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="779"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1268"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW78805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1291" mass="145083" checksum="BE59D7DA188D9DE9" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0J7</accession>
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        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL23m</fullName>
        </recommendedName>
    </protein>
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        <name evidence="5" type="ORF">HETIRDRAFT_28535</name>
    </gene>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
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        <property type="protein sequence ID" value="ETW79338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009550435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0J7"/>
    <dbReference type="FunCoup" id="W4K0J7">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K0J7"/>
    <dbReference type="GeneID" id="20669289"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_28535"/>
    <dbReference type="eggNOG" id="ENOG502S89F">
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    <dbReference type="HOGENOM" id="CLU_2326320_0_0_1"/>
    <dbReference type="InParanoid" id="W4K0J7"/>
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    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR013025">
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    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059">
        <property type="entry name" value="RIBOSOMAL PROTEIN L23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW79338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="99" mass="11500" checksum="3D1BA6834E8CC7E7" modified="2014-03-19" version="1" fragment="single">VIGQKVYLPNIIFRLVRNHTPPGQPYNPYEATFRIPMSVTKTDVRSYLASVYGVQTTYIRTDNYLSPITRAWNASWTATKSYRTYKRAVVGLVEPFYYP</sequence>
</entry>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <strain evidence="4 5">TC 32-1</strain>
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    <dbReference type="eggNOG" id="ENOG502QSII">
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    </dbReference>
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        <property type="entry name" value="Glucose_repression_reg"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW78701.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Velez H."/>
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                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
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    </dbReference>
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    </dbReference>
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            <end position="123"/>
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    <feature type="domain" description="HAM1-like N-terminal" evidence="1">
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            <end position="512"/>
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    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="Pfam" id="PF19343"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79397.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1E8</accession>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
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                <person name="Cullen D."/>
                <person name="Dalman K."/>
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                <person name="van Diepen L.T."/>
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                <person name="Hansson D."/>
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                <person name="Velez H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ETW79530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009549817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2F6"/>
    <dbReference type="GeneID" id="20677729"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_477117"/>
    <dbReference type="HOGENOM" id="CLU_2886073_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2F6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="63" mass="7057" checksum="15FFFF623E1937BF" modified="2014-03-19" version="1">MIQLFNSAAAKKITSGMSDIMEPLHVTRQKNVRRDPRSACMGRHGGTRPTSPQRFPASERLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2G0</accession>
    <name>W4K2G0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor 1-gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_419610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="FunCoup" id="W4K2G0">
        <property type="interactions" value="610"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K2G0"/>
    <dbReference type="GeneID" id="20673585"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_419610"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_3_0_1"/>
    <dbReference type="InParanoid" id="W4K2G0"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03181">
        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000006">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1010:FF:000001">
        <property type="entry name" value="Elongation factor 1-gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1010">
        <property type="entry name" value="Translation elongation factor EF1B, gamma chain, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001662">
        <property type="entry name" value="EF1B_G_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036433">
        <property type="entry name" value="EF1B_G_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00647">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01183">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89942">
        <property type="entry name" value="eEF1-gamma domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50040">
        <property type="entry name" value="EF1G_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="73"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="EF-1-gamma C-terminal" evidence="5">
        <location>
            <begin position="247"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="197"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW79992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="45365" checksum="C4E909ABFDAEB4AD" modified="2014-03-19" version="1">MSVGTLYASPAEAKRILVVAAFAGLTVEVKEPKAGLIKTPTLETADGFSVFEASAIGRYLASLAPNSTLIGSESKEAALVDQWVAFSDSYVTAYNNFIVRLVQGHITPYSKPIHTNVLDRLVGSLTTLEKHLATRTFLATERITLADITLATAIQSAVASTVDASLRSKLPNVFRHFETIINQPSLKSTFGETTYTEKAVQYTPPPKDKKEKKPEEAAAPKPKAEKKPKEQAEDDDDDKPFVEEPKAKNPLDSLPKSSLNLEDWKRAYSNKETRGAGGALEWLYQNFDKEGYSLWRVDFKYNEELTQTFMSSNQIGGFFNRLEASRKYLFGSVGVLGETNNSIITGALIARGQEIQPNVDCAPDWESYSYERLDLENPEHKAFFEGALAWDLEIDGKKWVDGKNVSLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2Q6</accession>
    <name>W4K2Q6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_441315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549575.1">
        <property type="nucleotide sequence ID" value="XM_009551280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2Q6"/>
    <dbReference type="GeneID" id="20675349"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_441315"/>
    <dbReference type="HOGENOM" id="CLU_2498142_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2Q6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="86" mass="9547" checksum="C31222476204F0B9" modified="2014-03-19" version="1">MMNSMSSSWEPIQIIGKLTSTRQVRATQSRYGACLGALKISPPHFEHRLEIDICIPSTGVPNESSGVWTDTSSGRSRQVRRCNIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2S0</accession>
    <name>W4K2S0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_387686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549588.1">
        <property type="nucleotide sequence ID" value="XM_009551293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2S0"/>
    <dbReference type="GeneID" id="20672326"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_387686"/>
    <dbReference type="eggNOG" id="ENOG502REQ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067506_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2S0"/>
    <dbReference type="OrthoDB" id="3630793at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014988">
        <property type="entry name" value="Uncharacterised_YqcI/YcgG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40045">
        <property type="entry name" value="YCGG FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40045:SF1">
        <property type="entry name" value="YQCI_YCGG FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08892">
        <property type="entry name" value="YqcI_YcgG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="291" mass="33330" checksum="5E845BB647685287" modified="2014-03-19" version="1">MTNYIVPASIFALVLAIFPRLRKFVFTRSNTIVSHHEKTHVNPDEGLFSRAQVDERFGEGSWQRAAYDNYTNVILNEELVFPCIYATKGFKTDDQLYMFIDSDDLSDPRHIRHLVANLQVYLPQSRALGPNTSLVLLAKINDNPRSIEEYNDLFWKMLDGAAQRDIKPWPNSIPRDMDTDKWCFCFGGEPFFTVIQTPAHQIRRSRHARGVTIVFQPKWIFDILFSTPAKRVGALAKVRALLAKYDPIPVSPELKDYGASGSREAQQYFLLDENIPAPYPYKMLSSPKVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3Y2</accession>
    <name>W4K3Y2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_103424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548574.1">
        <property type="nucleotide sequence ID" value="XM_009550279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3Y2"/>
    <dbReference type="GeneID" id="20665904"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_103424"/>
    <dbReference type="eggNOG" id="ENOG502RC00">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102259_1_0_1"/>
    <dbReference type="InParanoid" id="W4K3Y2"/>
    <dbReference type="OrthoDB" id="2603374at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW80050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="172" mass="19633" checksum="AAF4544B494980B4" modified="2014-03-19" version="1">MNAQQVTLEPSSLYVFTQPLLHGAFHWAFIHTDAHNHATIHHWAEQDRGPYAESYRMQDLAAGMNKLRNAPVLGYFKVEGYAAVDLSIFARICQDTFPSGWATVQQNRARGLSCRTWVVAVLAGMKAQRLLSRRDSAEDIERAIKTRSAEFDVIYMNDFLWQRAYQTVVISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4G9</accession>
    <name>W4K4G9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_440453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547423.1">
        <property type="nucleotide sequence ID" value="XM_009549128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4G9"/>
    <dbReference type="STRING" id="747525.W4K4G9"/>
    <dbReference type="GeneID" id="20675262"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_440453"/>
    <dbReference type="HOGENOM" id="CLU_1489204_0_0_1"/>
    <dbReference type="InParanoid" id="W4K4G9"/>
    <dbReference type="OrthoDB" id="7759664at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="181" mass="19039" checksum="B499D38510D32993" modified="2014-03-19" version="1">MPPPPMIETNHGPSWHHHNTAGRPILPNSLRPTPSYQQQGDSRSRGQDTALADRPSMSTLPPTLTEDQLTRLDRLTRDAIDERLRVLEGVSGAVYRCIEELTRVRSVLPPVPAQGAGVSLASSSRQASSSGSSGASASSATPEPLSRTTRDDGAAHSVRVSDDAVRDASVGSESVGLPSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5A6</accession>
    <name>W4K5A6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_320162</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547283.1">
        <property type="nucleotide sequence ID" value="XM_009548988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5A6"/>
    <dbReference type="FunCoup" id="W4K5A6">
        <property type="interactions" value="380"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K5A6"/>
    <dbReference type="GeneID" id="20670647"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_320162"/>
    <dbReference type="eggNOG" id="KOG4727">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067237_2_1_1"/>
    <dbReference type="InParanoid" id="W4K5A6"/>
    <dbReference type="OrthoDB" id="30343at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040107">
        <property type="entry name" value="Snu23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="183"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW80550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="225" mass="25982" checksum="85B82184FC086D91" modified="2014-03-19" version="1">MADKQGAYGNKAADTDFRRKWDKEEYAERAKKKDDEERDRMKENEERMKQGKKPLRGKKQDLPKPTELMKRREHDLELDKNLGKTMVVQNPGGRGPGQPGFYCDTCNRTYKDSVGYLDHINGRAHLRALGQTTRIERSTVQQVRARIAYLREKTKEASNAKAFDFEQRLTEIRDKELAARAEKKAQKKAERDKARLELAQDTTMNQDGDNMMSMMGFSGFGTSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5A7</accession>
    <name>W4K5A7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoglycerate mutase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_150646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547677.1">
        <property type="nucleotide sequence ID" value="XM_009549382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5A7"/>
    <dbReference type="FunCoup" id="W4K5A7">
        <property type="interactions" value="203"/>
    </dbReference>
    <dbReference type="GeneID" id="20667368"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_150646"/>
    <dbReference type="eggNOG" id="KOG1382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020880_2_2_1"/>
    <dbReference type="InParanoid" id="W4K5A7"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF42">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844010" description="Phosphoglycerate mutase-like protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW80992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="59409" checksum="AD59BEFB58AACAED" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5J3</accession>
    <name>W4K5J3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="10">FBP aldolase</shortName>
            <ecNumber evidence="5 10">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_410210</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="5 10"/>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547761.1">
        <property type="nucleotide sequence ID" value="XM_009549466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5J3"/>
    <dbReference type="FunCoup" id="W4K5J3">
        <property type="interactions" value="303"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K5J3"/>
    <dbReference type="GeneID" id="20672844"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_410210"/>
    <dbReference type="eggNOG" id="KOG4153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036923_0_0_1"/>
    <dbReference type="InParanoid" id="W4K5J3"/>
    <dbReference type="OrthoDB" id="35652at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00946">
        <property type="entry name" value="FBP_aldolase_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000013">
        <property type="entry name" value="Class II fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01520">
        <property type="entry name" value="FruBisAldo_II_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006628">
        <property type="entry name" value="PRK09197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559:SF0">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW81082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="361" mass="39654" checksum="4A34627E7D2DE2B3" modified="2014-03-19" version="1">MGILDIVPAGVLTGENVRKLFDYAKEHKFAIPVRRWINVTSSSTANAVLEAARDIKSPIILQVSQGGSAYFSGKGLANDKQQASIIGAVAAAHHIRTVAKAYGVPVVLHSDHCAEKLLPWFDGMLAADEEYFKQHQEPLFSSHMLDLSEEPKEQNIATCVKYFKRMAPIGLWLEMEIGITGGEEDGVDNTGVDNNSLYTQPEDVYEVYEALSKISPNFSIAAAFGNVHGVYKPGNVKLHPELLAKHQAYTKEKTGGKIEQPLFLVFHGGSGSTKEEIKTAVGNGVVKMNVDTDTQFAYLAGIRDFVLNKKDYLLSQVGNPDGADKPNKKFYDPRVWVREGEKTLSVRVKEACSDLGNTNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5R2</accession>
    <name>W4K5R2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycoside hydrolase family 18 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_62145</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546983.1">
        <property type="nucleotide sequence ID" value="XM_009548688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5R2"/>
    <dbReference type="STRING" id="747525.W4K5R2"/>
    <dbReference type="GeneID" id="20678585"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_62145"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002833_6_1_1"/>
    <dbReference type="InParanoid" id="W4K5R2"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF392">
        <property type="entry name" value="HAP41P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844089" evidence="9">
        <location>
            <begin position="18"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="36"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW81104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="422" mass="44253" checksum="3BAB1AEAAF073323" modified="2014-03-19" version="1">MIFPLSFLLVGAAFASALPDPTSVLNDLDCESGSDLVAASWYAGWHSADVPLSGVSWEKYTHMTYAFAETTPDPHKLSLANSDEQLLPEFVKSAHEHGVKALVSIGGWTGGLYFSSNVGDATNRTIFVNTVIDMVTTYGLDGIDIDWEYPNKLGVGCNVVSPSDTANLLFFLQELRAHPLGSTLIVTAASSISPWVDENGNASTDLSGFASVLTYVAVMNYDIWGSWSNAVGPNAPLDDACASPANQAGSATSAVQAWNAAGIPHDQIVLGVPGYGHSFRVSTAAALPNGADGALASYPAFNKADQPLGDRWDDANPGPDVCGNAQGAGGVFNFFGLVEGGFLNDNGTVAAGIAYAFDECSQTPFVYNSTSQVMVSYDNADSFAAKGKFINTLGLRGFAMWEAGGDFKDILVDSIRSASGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5S4</accession>
    <name>W4K5S4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_385902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547824.1">
        <property type="nucleotide sequence ID" value="XM_009549529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5S4"/>
    <dbReference type="STRING" id="747525.W4K5S4"/>
    <dbReference type="GeneID" id="20672258"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_385902"/>
    <dbReference type="eggNOG" id="ENOG502SK7C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039311_0_0_1"/>
    <dbReference type="InParanoid" id="W4K5S4"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="451" mass="51181" checksum="52F5501BEE27E040" modified="2014-03-19" version="1" fragment="single">MGVQPRGLVVKLTAIGALLSFITLLYFYTGASQRVRLPSLGSLFPSDGRARASCAPEAWADGHWARRRSPIGNETLTAPRDVFAYNGFDGCASDREFFWHLGADKEEQWDRFPDVLDYEWVPGEQCAGVRPLTGAALVRDLVEQGGWLVLGDSITENHFFSLSCTLFPHVRATPNYTENPYFDRAWPQNLYLNPSSPLLSSLRLPPGFSIEETPLITFRRVDLLLEQTEIESVHRTLHPELYADGSDFALFSDEKFWSLSPSEYMPMFTAPLPRAHYATLVVSTAGHWTTTLFGGLRDASRENDGYGIEHVLELFAAAMRRWAEDVQRAMDEDRRVQTRKALAGLRPVARQVVVRAYLPGHEDCHSFRAPWAERQPFKWNWYNWAWIGDMNARFQILASAASYPDIHFLPIDRPALLRPDAHATGDCLHLLTGAGVLEGWTHYIWHFVTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4K659</accession>
    <name>W4K659_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_317128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545973.1">
        <property type="nucleotide sequence ID" value="XM_009547678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K659"/>
    <dbReference type="GeneID" id="20670393"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_317128"/>
    <dbReference type="HOGENOM" id="CLU_099534_0_0_1"/>
    <dbReference type="InParanoid" id="W4K659"/>
    <dbReference type="OrthoDB" id="2548432at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="205" mass="22537" checksum="07FCC70684047F47" modified="2014-03-19" version="1">MGQCRASYKVPGAGTNWLAVIDSAVVFLMISATMGAVTIAMLLALLFFSTATLRRKPLFILNVVALLLGITVAIVNICAEIRILKHPIISGSPQIMMAMSVLIGIGPTLVDSILLLRIYSVFPPRTTPHIHLFFVMVIPILISVARFINSIIYINSYAHSVHTTTELGSASILIRSHLPCVKIEWFLQVFDNLLVGQKFMTCNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6N1</accession>
    <name>W4K6N1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_115919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547437.1">
        <property type="nucleotide sequence ID" value="XM_009549142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6N1"/>
    <dbReference type="GeneID" id="20666503"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_115919"/>
    <dbReference type="eggNOG" id="ENOG502SJVB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024804_1_1_1"/>
    <dbReference type="InParanoid" id="W4K6N1"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="462" mass="51286" checksum="717CAC54BC045578" modified="2014-03-19" version="1">MSSNPSTLTFAGDATVVSEHGPDAYERTSYYNGITGDGDYPDLVYRSDFLTTPFPKPVGRHAHVPVKSLRGVFDTPLNDVWDAVGPHIRDLIKAYEIHWSSGPPGEEAKGSLGPVVIWVGIILGSTSPNTAHDVSQEILKLLLKNGVEDAVVEWREAVPQSGNATHHVGHFLTALLGVLLANEEMEEGTLTLWFHENKDKDGNPSNKVYGVSNCHVLRKHTNVDYEHRGGTPMDYVRLCGIRRFQRSLDITKAIADHGILADLWARDIVELQAQEGQNREDAREMLRIRSKLDDENEAIADLEALYDQVTKEWSNIKLHRNIGHVQYAEAITVDEDDTRYTSDGCRCLIVGKDGNATDLTVGRYAGLVLFTRNEVGIESVELGIYNSGVKCVEVFSAKGDSGSLVWHTKNGQARIVGQLHSGHNKGGSTSNHVTYCTPGWYLLKQIKKRFRHADFYRTTRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W4K702</accession>
    <name>W4K702_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">MFS sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_173270</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546219.1">
        <property type="nucleotide sequence ID" value="XM_009547924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K702"/>
    <dbReference type="GeneID" id="20668432"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_173270"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_13_1"/>
    <dbReference type="InParanoid" id="W4K702"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF79">
        <property type="entry name" value="LACTOSE PERMEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="60"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW81588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="533" mass="58289" checksum="D8FEA170C86302A9" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7H6</accession>
    <name>W4K7H6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mur ligase central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_65092</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545904.1">
        <property type="nucleotide sequence ID" value="XM_009547609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7H6"/>
    <dbReference type="FunCoup" id="W4K7H6">
        <property type="interactions" value="177"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K7H6"/>
    <dbReference type="GeneID" id="20678716"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_65092"/>
    <dbReference type="eggNOG" id="KOG2525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015869_2_0_1"/>
    <dbReference type="InParanoid" id="W4K7H6"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF0">
        <property type="entry name" value="DIHYDROFOLATE SYNTHETASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW81772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="53153" checksum="942967AE2A027BC5" modified="2014-03-19" version="1">MSIDLSLDRIHTLLRYFPYTRPTVHIAGTNGKGSVSSFVSSILLAASISVGKFNSPHLVSIVDSITVDGQSVSDDVYGSARASVEAVNEKYSIEASNFEVLTCTALTIFERTKVDIVVLEAGMGGRLDATNAIPDTCVLVSALTAVDLDHQAFLGSTIGQISREKAGIARKGKTFVLGPQKHDEVGLVVKQVVGDVGAYLVTAVAARTRAWNTVVDGPQPPVFSLDSLHGADEEFQGPPYQPVEFIMTCFEQPVLSQLPLFGSHQLDNLGTAATIIDTLIVHPCAQRLSLRNKLTSNLVSRGIRATVWPGRLSFHTIPRRLLPVEDRPVWGTNPKLVVLADGAHNPASASTLATYISQLVRTKGADSSVYLTYILALSHSPPKTPLQTLSPLFSLSPPVNTQIHYSAAVTRFSPVAGMPWVQSVPPSTLAQVIKDLAPDADVWSPPDGQDSTQELKQALRWVSQKRHPQAAFVVLAGSLYLVADLYRLLKENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7J6</accession>
    <name>W4K7J6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_444923</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546387.1">
        <property type="nucleotide sequence ID" value="XM_009548092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7J6"/>
    <dbReference type="STRING" id="747525.W4K7J6"/>
    <dbReference type="GeneID" id="20675602"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_444923"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_12_1_1"/>
    <dbReference type="InParanoid" id="W4K7J6"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW81782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="30762" checksum="BAD5257930F46519" modified="2014-03-19" version="1">MSSSILRSETIFDLTGRVALVTGGGTGIGLMIASGLATNGAKVYIASRRKDVVQKVADEWRSQGPGTIIALSMDVTDRDSILEAKKVIQQADGKLHILVNNAGAVGPTTPFLNNLQAPEHKDAETLGNALFNDAGFNAWSSLYSINTSSVYYVTTAFLGLLDNGSKDIPGYTASVINITSISGVISLAQGHFCYNSSKAAASHLTKMMATEFALKGIPVRVNAIAPGVYASEMTFDAIEGPEAVAKIAQSVVPVPAARSGTPGEIAGTVIYLSSLAGCYTNGQEIVVDGGYVAVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7P0</accession>
    <name>W4K7P0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aspartic peptidase DDI1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_51345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_009545839.1">
        <property type="nucleotide sequence ID" value="XM_009547544.1"/>
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    <dbReference type="AlphaFoldDB" id="W4K7P0"/>
    <dbReference type="STRING" id="747525.W4K7P0"/>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_51345"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003921_0_1_1"/>
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    <dbReference type="OrthoDB" id="5596707at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="39912" checksum="E41DB3200D2A83B4" modified="2014-03-19" version="1">MAQTGRSTLSPSLTPERRVRTETPEPEPRPTTPTQRPPPVPAKDDAPIHPYAKAQDATYAPPHERNIGAPAKIPSAKKDAPAYKTTAPIYDEKVAAEVYNRAMATQVTLTQRELLSLSAEVRSQVREATSARRSPARDASNVRTFYQDADLPYAIDDLEPPTRPTVSSFVNVLHQPETPPPGATIIPDMYETYLKNLQPGQVPQPLIVAKESSALRSIVPLVDHQQEVECVIDPGSQVIAMSEGICNELALIYDPEIILNMQSANGEIDRSLGLARNVPFLIGDITLYLQVHIIQNPAYDVLLGWPFDILTESIVKNYSNEDQTITISDPNIGRRATIPTIRRGPPRVLHRRQAGFRNSMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7P7</accession>
    <name>W4K7P7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bms1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_169847</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547777.1">
        <property type="nucleotide sequence ID" value="XM_009549482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7P7"/>
    <dbReference type="FunCoup" id="W4K7P7">
        <property type="interactions" value="474"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K7P7"/>
    <dbReference type="GeneID" id="20668243"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_169847"/>
    <dbReference type="eggNOG" id="KOG1980">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009858_1_0_1"/>
    <dbReference type="InParanoid" id="W4K7P7"/>
    <dbReference type="OrthoDB" id="119302at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22298">
        <property type="entry name" value="Tsr1_G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="6">
        <location>
            <begin position="85"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="393"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW81101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="790" mass="88932" checksum="DC8C176B3D8F17C5" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7X4</accession>
    <name>W4K7X4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_452567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547836.1">
        <property type="nucleotide sequence ID" value="XM_009549541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7X4"/>
    <dbReference type="GeneID" id="20676269"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_452567"/>
    <dbReference type="HOGENOM" id="CLU_1777704_0_0_1"/>
    <dbReference type="InParanoid" id="W4K7X4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="146" mass="16757" checksum="D802D647708762E5" modified="2014-03-19" version="1">MHAHTLHNEQMDDEGRTDDARNLTEHARCATVRTRRALGTPLGICRHLCRTREWWGPRIPSTASMPAGCIHYPFGDGRYPHVHARGSMGDRDPQCALDDIARWPPRLHQSRFTSPYLIRFEAHSRFQRRCRAALPASSPQSLLRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4K805</accession>
    <name>W4K805_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_318819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546470.1">
        <property type="nucleotide sequence ID" value="XM_009548175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K805"/>
    <dbReference type="STRING" id="747525.W4K805"/>
    <dbReference type="GeneID" id="20670540"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_318819"/>
    <dbReference type="eggNOG" id="ENOG502RXTC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061244_0_0_1"/>
    <dbReference type="InParanoid" id="W4K805"/>
    <dbReference type="OrthoDB" id="2310204at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844342" evidence="1">
        <location>
            <begin position="19"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="265" mass="28185" checksum="7F81FD12F3AEF0D3" modified="2014-03-19" version="1">MSSAALISLLLSSIPVSATLEHRASSQGYYDPRDKGGSFLTQVPGTFPAGLGEPLNAIILGSSDETVLVDQETDGGLRNYFLSFGFAGECLGQHSGSDQGANLGDGNGSKNETAVIRWDYGNPTFGTCQETIQGGNHFRYWVQDGKDADSGAIFLAVSYELPDKQQHDIIYNGYNLARDWLVGNVTAQSSVIPTSNLTNQSIYSGQTSFDGYIYQTNVQYVSGLLSNTSDGINHYLSVGANGTNAVDGLVALLEVRLLSKPSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4K914</accession>
    <name>W4K914_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cyclopropane-fatty-acyl-phospholipid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_36898</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545790.1">
        <property type="nucleotide sequence ID" value="XM_009547495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K914"/>
    <dbReference type="GeneID" id="20671834"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_36898"/>
    <dbReference type="eggNOG" id="ENOG502QSMW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026434_0_0_1"/>
    <dbReference type="InParanoid" id="W4K914"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050723">
        <property type="entry name" value="CFA/CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667">
        <property type="entry name" value="CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667:SF2">
        <property type="entry name" value="FATTY ACID C-METHYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW81830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="378" mass="43171" checksum="5D9EFE96CC4F08EC" modified="2014-03-19" version="1">MGDLGFSEAYMYGEVECDDLLPVFLIFIHNRESLQNLDSNFSWLFSLPQRLTSYRFLNTLSNSRSNISAHYDLSNDMFSGMHAPTSEMYLCPSASPPPSSPPDFNDELHAGQILKLQHITRKACILPGHRILEIGSGWGALALHIAQGVPDTQIDTLTLSAHQHSYVTQLIEKHGLEDRVRVHLMDYREIPTEWTGRFDRVVSVEMLEAVGKENYETYWSVIDHVLKEKDAVGVVQVITIPEGRFDKYEKEVDFIRKWVFPGGLLPTLSVLHATLTSATSGRLLVDSVSNIGPHYARTLREWRRRFIDNFHTIEEALRREHPGAFDGPNGQTELQVFWRKWICYFCYCEVGFTTRLLNDHVIAFTREANGAMGCNTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9G4</accession>
    <name>W4K9G4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NF-X1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_108751</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NFX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544837.1">
        <property type="nucleotide sequence ID" value="XM_009546542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9G4"/>
    <dbReference type="STRING" id="747525.W4K9G4"/>
    <dbReference type="GeneID" id="20666383"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_108751"/>
    <dbReference type="eggNOG" id="KOG1952">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_559039_0_0_1"/>
    <dbReference type="InParanoid" id="W4K9G4"/>
    <dbReference type="OrthoDB" id="6512771at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034078">
        <property type="entry name" value="NFX1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360:SF12">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR NF-X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="NF-X1-type" evidence="11">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="11">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="362"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW82477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="488" mass="52988" checksum="3C822FD87B2E3718" modified="2014-03-19" version="1">MSSFSSTARLKTLLILDLRCHAHTTPLRPLHANPALKPTRAFIIPSSRSRHWRCTLPSYLTAAPSTANTFAPSMSCTTATQFPPTWSCSPAFVPHDPDVAPPAGHEHEQERVKCCWTTFHLKCVRLWAAKSIKDIEDAWCRRGESGRKDDWCCHGTQFKRKFVPHCYRCFCGSTQDPKPPCLSMPHSCASPCSRSRVCGHPCALACHPGLCPPCQVTTQRPCCCGKQTVSLWRSHTSPAPAHLSSTADATHTDLSCGCTCEKRLACGNHVCAEPCHPGVCLPCAVTKAARCWCGKVEKRLACGEGEKEACAVCTQPCHPPSRTPPPYPLSPAFTTHCPCGKHPLYPHTCPSSLIRHRPHHLRPRSLHSPRSTRPWHPRTLPSPSPLPAAAPAASAASHAVSSPMSTAIRKLQRRLESQRMSHKVAVQAYTKERDTLKSMLVRTGGGASAEPYVNGTGSWTGSGGVNGAAESVASELQEVVPESELVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9K2</accession>
    <name>W4K9K2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">tRNA(His) guanylyltransferase</fullName>
            <ecNumber evidence="2 12">2.7.7.79</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">tRNA-histidine guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HETIRDRAFT_384464</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 5'-end ribonucleotide-tRNA(His) + GTP + ATP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54564"/>
            <dbReference type="Rhea" id="RHEA-COMP:14193"/>
            <dbReference type="Rhea" id="RHEA-COMP:14917"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:141847"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.7.79"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the tRNA(His) guanylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.79" evidence="2 12"/>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546609.1">
        <property type="nucleotide sequence ID" value="XM_009548314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9K2"/>
    <dbReference type="FunCoup" id="W4K9K2">
        <property type="interactions" value="349"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K9K2"/>
    <dbReference type="GeneID" id="20672205"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_384464"/>
    <dbReference type="eggNOG" id="KOG2721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044271_1_0_1"/>
    <dbReference type="InParanoid" id="W4K9K2"/>
    <dbReference type="OrthoDB" id="62560at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008193">
        <property type="term" value="F:tRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025845">
        <property type="entry name" value="Thg1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024956">
        <property type="entry name" value="tRNAHis_GuaTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007537">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038469">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729:SF6">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04446">
        <property type="entry name" value="Thg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14413">
        <property type="entry name" value="Thg1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028980">
        <property type="entry name" value="tRNAHis_guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 12 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNAHis guanylyltransferase catalytic" evidence="16">
        <location>
            <begin position="6"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Thg1 C-terminal" evidence="17">
        <location>
            <begin position="139"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="224"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="29"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="75"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF14413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETW82030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="353" mass="39315" checksum="6DDB05677FD5C482" modified="2014-03-19" version="1">MAESRFEYVKGFELPDPLLPDTYMLMRVDGHSFHRFSAEHNFEKPNDERALRLMDRAARAVMDEYPDVVLAFGESDEYSFLLRKSAALYNRRHAKILSTLTSLFTAAYVMHWPAHFPDEPLRYAPAFDARIVLYPSARAVRDYFAWRQADTHINNLYNTTFWALVQQGGLSTKEAHESLRGTVSGQKHEILFSRFNVNYNALPARFRKGSVMVREEIPDEELVGVPMGSVSAADPVGESSSGTQSTSENIGPEGHATSATQPDTLAERSPSDPDVLESSQPDAPPMLPQGADNKGSKKAQKRLARAQAKGAASGAQKKDRGEKGKARRTRVVLVHCDVIGDAFWDARGYLLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9V4</accession>
    <name>W4K9V4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_165327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544890.1">
        <property type="nucleotide sequence ID" value="XM_009546595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9V4"/>
    <dbReference type="GeneID" id="20667979"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_165327"/>
    <dbReference type="HOGENOM" id="CLU_2849960_0_0_1"/>
    <dbReference type="InParanoid" id="W4K9V4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="65" mass="7595" checksum="0B75E199CE5EDF4C" modified="2014-03-19" version="1">MPRNLRQMMRWRPADMYEHACFPARLNIRSTSLEVNCPSNTSCFSVVRFSTSRARTILRATALFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4KA62</accession>
    <name>W4KA62_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxalate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">oxd2</name>
        <name evidence="6" type="ORF">HETIRDRAFT_127302</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545006.1">
        <property type="nucleotide sequence ID" value="XM_009546711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KA62"/>
    <dbReference type="GeneID" id="20666987"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_127302"/>
    <dbReference type="eggNOG" id="ENOG502QQ0P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030515_2_0_1"/>
    <dbReference type="InParanoid" id="W4KA62"/>
    <dbReference type="OrthoDB" id="10263073at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20305">
        <property type="entry name" value="cupin_OxDC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20304">
        <property type="entry name" value="cupin_OxDC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF9">
        <property type="entry name" value="SLL1358 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844374" evidence="4">
        <location>
            <begin position="22"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="5">
        <location>
            <begin position="106"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="5">
        <location>
            <begin position="284"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW82668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="437" mass="47668" checksum="57A6BC44BB38955A" modified="2014-03-19" version="1">MLHLTSSLQLCALFLTLSVSAAPASKPSAPTLVSAASPSPTFPLATDSPNAPAFHAGADIQPEPIRGKLGSNIIGPQNVEIDRQNPDFLAPPTTDNGEVLNAKWPFSLSHNRLQTGGWARQQNIHDMPIAKQMAGVNMRLDPGAVRELHWHGTSEWAYVIKGSTQITAVDQDGKNYLANVNAGDIWYFPPGVPHSLQATNESTEGTEFLLVFDDGDFSEDATFLLTDWLAHVPKEVIAKNFQTDISAFNNIPAKELYIFPSEDPSLDAVPVPDPQGQVPNALSFAMSTMNATRTRGGTIKIVDSTIFPIAKTLAVADVTVEPGAMRELHWHPTQDEWAYFIEGNARVTVFASQSNARTFDYQPGDVGYVPATYGHYVENVGNTTLHYLEIFKTDRFQDVSLSQWLALTPPALVKAHLGLSDETISGFQKTKQYIVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAP2</accession>
    <name>W4KAP2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_315713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545113.1">
        <property type="nucleotide sequence ID" value="XM_009546818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAP2"/>
    <dbReference type="STRING" id="747525.W4KAP2"/>
    <dbReference type="GeneID" id="20670250"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_315713"/>
    <dbReference type="eggNOG" id="ENOG502SYV4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042824_0_0_1"/>
    <dbReference type="InParanoid" id="W4KAP2"/>
    <dbReference type="OrthoDB" id="3244156at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="517" mass="55951" checksum="CEE16A1F237EEAA8" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAX5</accession>
    <name>W4KAX5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_157168</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545279.1">
        <property type="nucleotide sequence ID" value="XM_009546984.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="W4KAX5">
        <property type="interactions" value="130"/>
    </dbReference>
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    <dbReference type="GeneID" id="20667703"/>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
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</entry>
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    <accession>W4KBC1</accession>
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        </lineage>
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                <person name="Broberg A."/>
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                <person name="Cullen D."/>
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                <person name="van Diepen L.T."/>
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                <person name="Gonthier P."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
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        <source>
            <dbReference type="EMBL" id="ETW83098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
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</entry>
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            <taxon>Heterobasidion</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Broberg A."/>
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                <person name="Cullen D."/>
                <person name="Dalman K."/>
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                <person name="Kues U."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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            <end position="45"/>
        </location>
    </feature>
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        <location>
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            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBQ7</accession>
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    </protein>
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        <lineage>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
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            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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                <person name="Cullen D."/>
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                <person name="Fossdal C.G."/>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
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    <dbReference type="EMBL" id="KI925457">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="747525.W4KC29"/>
    <dbReference type="GeneID" id="20676913"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_458451"/>
    <dbReference type="eggNOG" id="ENOG502RZBP">
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    <dbReference type="HOGENOM" id="CLU_007969_0_0_1"/>
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    <dbReference type="OrthoDB" id="2563978at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="region of interest" description="Disordered" evidence="1">
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    </evidence>
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    </evidence>
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        <source>
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<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
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                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
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        <property type="nucleotide sequence ID" value="XM_009546917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KC37"/>
    <dbReference type="STRING" id="747525.W4KC37"/>
    <dbReference type="GeneID" id="20672737"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_408933"/>
    <dbReference type="eggNOG" id="ENOG502QVXD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_468551_0_0_1"/>
    <dbReference type="InParanoid" id="W4KC37"/>
    <dbReference type="OrthoDB" id="1938591at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="582" mass="62480" checksum="4414F3385FF2D55A" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCC2</accession>
    <name>W4KCC2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">P-type ATPase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_408798</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545762.1">
        <property type="nucleotide sequence ID" value="XM_009547467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCC2"/>
    <dbReference type="STRING" id="747525.W4KCC2"/>
    <dbReference type="GeneID" id="20672726"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_408798"/>
    <dbReference type="eggNOG" id="KOG0206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145784_1_0_1"/>
    <dbReference type="InParanoid" id="W4KCC2"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="4">
        <location>
            <begin position="61"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW83517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="107" mass="11816" checksum="E0F9A2226B77D50A" modified="2014-03-19" version="1">MCKAVICCRVSPLQKALVVKLIKKNQKSILLAIGDGANDVSMIQAAHIGIGISGVKGLQAARSADIDILQFRFLKKLLLVLGAWSYQCLSKPILYSFYKNIVLYMQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCD5</accession>
    <name>W4KCD5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_126211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545065.1">
        <property type="nucleotide sequence ID" value="XM_009546770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCD5"/>
    <dbReference type="GeneID" id="20666934"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_126211"/>
    <dbReference type="eggNOG" id="ENOG502S1IW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1865351_0_0_1"/>
    <dbReference type="InParanoid" id="W4KCD5"/>
    <dbReference type="OrthoDB" id="5562739at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR XBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="2">
        <location>
            <begin position="30"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW82736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="132" mass="15052" checksum="54C2620A7C68EFC1" modified="2014-03-19" version="1">MASGLLQESATAGPRFRPYASPNHHVTKSRYITSNDSRGYIPVYEYPLNGQWIMMDADDGYILWTGIWKALGNSKADIVKMIESQPDLASVIRRVRGGYLKIQGTWMPYEVALRLSRRVAWPIRHELIPLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCP2</accession>
    <name>W4KCP2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_380746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543333.1">
        <property type="nucleotide sequence ID" value="XM_009545038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCP2"/>
    <dbReference type="FunCoup" id="W4KCP2">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KCP2"/>
    <dbReference type="GeneID" id="20672038"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_380746"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_12_1_1"/>
    <dbReference type="InParanoid" id="W4KCP2"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="343" mass="37700" checksum="A0977C50A5E29ADA" modified="2014-03-19" version="1">MPSRTNIFITGVTGYIGGTVLQRLLHHPSSDNFHITAFLRSEDKASKLTAFGVKTIIGSLDDFNKLAQLSADADVVIHTASADHLEYAKAILRGIKERFVKTGVAPILIHTSGTGVFMDDARGEYGQDHIYYDTNIQDMESLPATAPHRNVDIEVTEADKLGYVRTFIILPSTIYGIASGPLVDLGIQNPYSIQVPYTIRASLARGSAAVVGQGLNVWNNVHIDEVGDLYRVVFDSALKDLNTPHGRQGYYFAENGEYSQVELAREIGRVMHELGMAKSQAPTKLSDEENMKYLGGWLFGTNARTKGEMGRSLGWKPVKTSRDFFASIRQEVEALSPSSKTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4KD90</accession>
    <name>W4KD90_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_170266</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543548.1">
        <property type="nucleotide sequence ID" value="XM_009545253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KD90"/>
    <dbReference type="GeneID" id="20668274"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_170266"/>
    <dbReference type="eggNOG" id="ENOG502SR1D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056202_0_0_1"/>
    <dbReference type="InParanoid" id="W4KD90"/>
    <dbReference type="OrthoDB" id="1923159at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="125"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW83802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="293" mass="33291" checksum="0E4363E36C4DEA40" modified="2014-03-19" version="1">MRKHRQEIKLLENRNAQLEAEIEKLHDSANTSIQPRRGRSGGPTNAGLQAQVKRLKGEVEALKKDRAKDKKKIQRLQIKEVEADMKELHDEQVNGVTDVSNQMRKLLRRFQDIILSGALEDKEECTICLETMEVNGCSSLSCQHIFCNDCLSRLEPGSVEVTCPQCREKCAREEFEVVKFSTGEQWDQLLEVANDFARIDIRGEQEISEEEDEEPFIDDKDPDASSTASEFQTAPAARNSMSLDPDPVPAEAIIPDSTSDDGVPQFVYSRASASEKRKWLAQMADQRRKRRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KE48</accession>
    <name>W4KE48_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fungal STAND N-terminal Goodbye domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_312718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543373.1">
        <property type="nucleotide sequence ID" value="XM_009545078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KE48"/>
    <dbReference type="GeneID" id="20669976"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_312718"/>
    <dbReference type="HOGENOM" id="CLU_1468335_0_0_1"/>
    <dbReference type="InParanoid" id="W4KE48"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031350">
        <property type="entry name" value="Goodbye_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17109">
        <property type="entry name" value="Goodbye"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal STAND N-terminal Goodbye" evidence="1">
        <location>
            <begin position="14"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="184" mass="20760" checksum="0D91A2017183A103" modified="2014-03-19" version="1">MPDSNPGSQFHNIWKSALTKYKRDTDRDYFEGWLGEDSPDALFRLLDDELKSFKHFQEYRKKGEKVRRAIEPVLNMVNVFSETIGEGVAMAFSPAKAVSVAIRVLINGARDVSAHYDMIIEMFEKLKGFMGRLDVYIKQNITGKLKGLIVDILAQVLVVLGVATKWINQNRLCKGVALFTGECG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4KE77</accession>
    <name>W4KE77_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-canonical E2 ubiquitin-conjugating enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_62277</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543250.1">
        <property type="nucleotide sequence ID" value="XM_009544955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KE77"/>
    <dbReference type="GeneID" id="20678592"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_62277"/>
    <dbReference type="eggNOG" id="ENOG502QRJJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021807_0_0_1"/>
    <dbReference type="InParanoid" id="W4KE77"/>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018553">
        <property type="entry name" value="E2_Ub-conjug_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057668">
        <property type="entry name" value="E2_Ub-conjug_enz_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31560">
        <property type="entry name" value="UPF0652 PROTEIN C16A11.03C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31560:SF0">
        <property type="entry name" value="UPF0652 PROTEIN C22H10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09418">
        <property type="entry name" value="DUF2009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-canonical E2 ubiquitin-conjugating enzyme C-terminal" evidence="3">
        <location>
            <begin position="43"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="197"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW83625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="504" mass="57625" checksum="0D2D490503FE6F58" modified="2014-03-19" version="1">MDTEEDEDLDGELEYLVPAPAPELVLGAQPTLGSDPGEWYVERTKYIPIRLTLTERKFLRLLEAALQVSEYTDKIDTLGFGLSKAKRIVHQIRELCAVLAGLVLAADYKQGQELFTDRDFQSNASFYQRIFELGRRHKIMNPDKMRTTYGKLIYMLQDSQSPEVKDMLSFSCVTPIKTVHSLLEEHSALDLLRDPLITTATQEINSAKRSRREIQKDIKAKERAIETLSSRYSTADLSQEQVRQALYSIGDNHAFLRVNRDPCERMIDYLKQYFHPSQPKDKKGKDSLAIRSGKGGARLSHDHSKQYVYVLQSLSLWREILHDMFHLWSLAEQDLLSENVMYRLRDTGQGLNRVQAAPKTSRMMYAILHRAQKSVGSWVGSSVVHMGDHNVPNALIFIDKYSQIYRILLPICNTLLKLPDVYSSPALRAYIDAEYGSLDNLYMEILGDFFRHAFDGSGADNFYDAGSCIDGRLTSAWNWCAGLEKKRYFPIFLLTGFVGFDGEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEP1</accession>
    <name>W4KEP1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Riboflavin kinase</fullName>
            <ecNumber evidence="4">2.7.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Flavin mononucleotide kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_415995</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="4"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543973.1">
        <property type="nucleotide sequence ID" value="XM_009545678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEP1"/>
    <dbReference type="FunCoup" id="W4KEP1">
        <property type="interactions" value="301"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KEP1"/>
    <dbReference type="GeneID" id="20673281"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_415995"/>
    <dbReference type="eggNOG" id="KOG3110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048437_3_2_1"/>
    <dbReference type="InParanoid" id="W4KEP1"/>
    <dbReference type="OrthoDB" id="276388at2759"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749:SF6">
        <property type="entry name" value="RIBOFLAVIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Riboflavin kinase" evidence="12">
        <location>
            <begin position="43"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW84288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="202" mass="22579" checksum="F19C93E2CF21B458" modified="2014-03-19" version="1">MTVDDIHPTAEAIQALPERPNAPLRTETFRNSRPDIVGPDTPEPPFPIHLSGAVQRGFGRGGKDLGCPTANLPDDSITPMSHVCETGIYYGYAQVLRPKDGHSFPDDDAKVHPMVMSLGWNPFYKNERLTAEIHLLHDYKSDFYGNEMRALVLGYIRPELDYTSREALINDIEIDKSVALRSLARPAYAKLSSDPHFHPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4KES2</accession>
    <name>W4KES2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_314366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543350.1">
        <property type="nucleotide sequence ID" value="XM_009545055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KES2"/>
    <dbReference type="GeneID" id="20670116"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_314366"/>
    <dbReference type="HOGENOM" id="CLU_415631_0_0_1"/>
    <dbReference type="InParanoid" id="W4KES2"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="500"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW83571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="635" mass="69239" checksum="7A9732FEA342DB8D" modified="2014-03-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFH4</accession>
    <name>W4KFH4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_449940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544144.1">
        <property type="nucleotide sequence ID" value="XM_009545849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFH4"/>
    <dbReference type="GeneID" id="20675993"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_449940"/>
    <dbReference type="HOGENOM" id="CLU_739792_0_0_1"/>
    <dbReference type="InParanoid" id="W4KFH4"/>
    <dbReference type="OrthoDB" id="10677286at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="374" mass="40377" checksum="E4436F13770F6CBB" modified="2014-03-19" version="1">MSLATTPYPSERENLPPTVLYNLSSASLPPSDITVASRMMLSPASLASSCPPTPIGGVRSGSPIKVRYSAGSLKVRSMREDAMPTPISLSFPIAHNASSKTSSRSKPFEFCEEDGEDEEDDIPPHTRAFPLTFPRYANARRFPLSEDSQSLLRLATANVARQRRRLTSIPDWATLFRAQPTHSRLPIPFSTFIPFPTRMSRPVLPPLHIPSSGSKFFETGLPPQGCDTDDTDDTEGEGSSNSSTPSEPPSELLSEPPSPRPSASLHGTLTTRLFARYAAARKSMRAPHATSFRRSSSASSVRSAPAAPRPKASFLRRIAPRGLALRTRSLPVRVDVETSTRVDGGERAGARAGAGVGRSASVRRAASEKLRGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4KG04</accession>
    <name>W4KG04_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450 monooxygenase 88</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cyp88</name>
        <name evidence="9" type="ORF">HETIRDRAFT_170467</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543718.1">
        <property type="nucleotide sequence ID" value="XM_009545423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KG04"/>
    <dbReference type="GeneID" id="20668286"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_170467"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1061943_0_0_1"/>
    <dbReference type="InParanoid" id="W4KG04"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW83996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="262" mass="29327" checksum="6FD1B566B73369EA" modified="2014-03-19" version="1">MLAVEIAVSLLVACGISLIWKVVTRWVKQTPLRNIPGPPSKSLWSGNMSQVHDHHGWKFHADIAADYGRIVKLSGILGDSFLYVSDTRSLYQILFKDSAAFEEPSELIESGVDSRDHHKRQRKLLNPVFSSSHMRYMTPIFDRIAHQLRDILSGKVGDGNGKAEVDIMDWMTRAALEIIGQGGLGYSFDTMNVNANNAYANATKTLLPTIASPHMTVPAVCGQGRKHRFPKARRPISPMENMAITCRHRGCHGSYFSRRIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4KG59</accession>
    <name>W4KG59_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="4 12">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">5-proFAR isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_381409</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="4 12"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543777.1">
        <property type="nucleotide sequence ID" value="XM_009545482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KG59"/>
    <dbReference type="FunCoup" id="W4KG59">
        <property type="interactions" value="352"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KG59"/>
    <dbReference type="GeneID" id="20672074"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_381409"/>
    <dbReference type="eggNOG" id="KOG3055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065050_0_0_1"/>
    <dbReference type="InParanoid" id="W4KG59"/>
    <dbReference type="OrthoDB" id="446074at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04723">
        <property type="entry name" value="HisA_HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000110">
        <property type="entry name" value="1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011858">
        <property type="entry name" value="His6/HISN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02129">
        <property type="entry name" value="hisA_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090:SF2">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW84061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="263" mass="28765" checksum="414A30F5C92C20FD" modified="2014-03-19" version="1">MLSSTPRSRFRPCIDLHDGQVKQIVGGTLSESDPTTLKTNFVATDSPGDFARLYRDHGLEGGHLIKLGPRNDDAAQEALRAWPGGLQVGGGIDDKNALKWIDLGASKVIVTSYLFRDLCFSLERLQLLCSIVGKDRLVVDVSCRRRGDKWFVAMNKWQDVTSMEVCKETLDLLAEFCSEFLIHAADVEGLCQGIDEALVTKLGEWVNIPTTYAGGAKDISDLDLVQRLSGGKVDLTYGSALDIFGGKLVNFEELVQRNKAGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGF4</accession>
    <name>W4KGF4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_439152</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544063.1">
        <property type="nucleotide sequence ID" value="XM_009545768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGF4"/>
    <dbReference type="FunCoup" id="W4KGF4">
        <property type="interactions" value="276"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KGF4"/>
    <dbReference type="GeneID" id="20675111"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_439152"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_1_1"/>
    <dbReference type="InParanoid" id="W4KGF4"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="29"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW84385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="504" mass="54300" checksum="A13CDCAD4395E7F4" modified="2014-03-19" version="1">MALVAQITVPRSNTTISVPTGLFINNEFVPSEDPSKSITVVNPATEEVLCSISAASEKDVDRAVNAAREAFRTTWGKNVTGFERARLINKLADLIERDQQVLAELECINNGKPVKIARDFDIGDSIGCLRYYAGWADKIVGQSIEIDRKTKFAITHPEPIGVCGQIIPWNYPIQMWAWKVAPALAVGCTIVMKPSEITPLTALKLSELVKEAGFPPGVINTIPSMGSVGGAALAAHMDVDKVAFTGSTITGRRIMEAAAKSNLKKVSLELGGKSPQLVFESADLDQAANWAALGILYNTGQDCTAGSRLYVQDTIYEKFLALLASKAQELVIGDGFDEASGGGPVVSKAQYDRVWGYINSGKQEGARIVIGGEKRAGVGFYVEPTIFADIRPDMKVVKEEIFGPVLVVGKFQTEEEAIALANDTTYGLAAGLHSNDAAQCARVSSALEAGTIWINQYNLLYNNVPFGGKKQSGIGRELGSHALDEYISTKAVHWNYGEKLAWPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGI8</accession>
    <name>W4KGI8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_448251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW84978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541875.1">
        <property type="nucleotide sequence ID" value="XM_009543580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGI8"/>
    <dbReference type="GeneID" id="20675838"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_448251"/>
    <dbReference type="HOGENOM" id="CLU_2210389_0_0_1"/>
    <dbReference type="InParanoid" id="W4KGI8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW84978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="107" mass="11817" checksum="CFB3F939E3C525FB" modified="2014-03-19" version="1">MSLSTPLPSPPPSPLSARTRLRLRSEVACYPPAYRLQPTLVHRLDPPRCPALSALVLSARAQIIAKRMPRTLQCVDEEVNPASDACTCDPATHIRPHASYRSHSRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHU9</accession>
    <name>W4KHU9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_100907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542296.1">
        <property type="nucleotide sequence ID" value="XM_009544001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHU9"/>
    <dbReference type="GeneID" id="20665719"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_100907"/>
    <dbReference type="eggNOG" id="ENOG502SFUG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042827_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHU9"/>
    <dbReference type="OrthoDB" id="3364736at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004354">
        <property type="entry name" value="Meiotic_Rec114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03525">
        <property type="entry name" value="Meiotic_rec114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="405" mass="43658" checksum="E75993DC55A04FE5" modified="2014-03-19" version="1">MLHSTTSTGSFDIVKYSRSYPPPSIAGSESQASQRTLAPQPDWQHFFNPLMRLVLDITKSERGELESVRLRILWYMDGGPVPANDAMDIDQRDPVVFEDLDLLSFSSLPSLGATMHGPPLRAAYRDSVVMIRYLHRRESATPAGAFRRFQINFQSPDAASQFIDGIRVVCPCKENGASAPASAPARNLNPTMSLAPKLCAIAPQPSALSRGLSTDTPDHARSSSSSGLSVTSFGFGRDPASRFSSLPLDSSSQLSSALPSPNPLARTNSTLRLNSGAMVPLVSEVRRNKARDISSLVQSLHPSSSLPPSSPPSSSAPGHDASMPPPPVPVVSSDSRERASTEPQAGISETQRSLFLSSLRETSELYKLSRPELESLVNDVVRQPGFAQILESLNTLWVAKGFVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHV4</accession>
    <name>W4KHV4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial</fullName>
            <ecNumber evidence="20">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">HETIRDRAFT_379356</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 20">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="18">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 20">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 20">Mitochondrion inner membrane</location>
            <topology evidence="1 20">Peripheral membrane protein</topology>
            <orientation evidence="1 20">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="20"/>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542285.1">
        <property type="nucleotide sequence ID" value="XM_009543990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHV4"/>
    <dbReference type="SMR" id="W4KHV4"/>
    <dbReference type="FunCoup" id="W4KHV4">
        <property type="interactions" value="220"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KHV4"/>
    <dbReference type="GeneID" id="20671967"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_379356"/>
    <dbReference type="eggNOG" id="KOG2403">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_6_1_1"/>
    <dbReference type="InParanoid" id="W4KHV4"/>
    <dbReference type="OrthoDB" id="71672at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000482">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:001062">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 18 20" id="KW-0274">FAD</keyword>
    <keyword evidence="6 18 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 20" id="KW-0813">Transport</keyword>
    <keyword evidence="5 20" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="21">
        <location>
            <begin position="52"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="22">
        <location>
            <begin position="502"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="57"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
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    <dbReference type="RefSeq" id="XP_009544450.1">
        <property type="nucleotide sequence ID" value="XM_009546155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIF3"/>
    <dbReference type="GeneID" id="20675131"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_439362"/>
    <dbReference type="HOGENOM" id="CLU_2460738_0_0_1"/>
    <dbReference type="InParanoid" id="W4KIF3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="89" mass="9503" checksum="B79573C84D3E2359" modified="2014-03-19" version="1" fragment="single">QRRSSRASLIVPTGTLHPQIVLRPTTLAHATSSANSITITTTFPLLVFTSTASTHTTAIISAVSPLTPSHSFHAPRDPPTSKRLAVLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIL7</accession>
    <name>W4KIL7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peroxidase</fullName>
            <ecNumber evidence="7">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hpox7</name>
        <name evidence="9" type="ORF">HETIRDRAFT_168564</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the peroxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="7"/>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542043.1">
        <property type="nucleotide sequence ID" value="XM_009543748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIL7"/>
    <dbReference type="GeneID" id="20668166"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_168564"/>
    <dbReference type="eggNOG" id="KOG4157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004824_4_0_1"/>
    <dbReference type="InParanoid" id="W4KIL7"/>
    <dbReference type="OrthoDB" id="2144714at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF53">
        <property type="entry name" value="HEME PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 7 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006994348" description="Peroxidase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="8">
        <location>
            <begin position="124"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW85165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="536" mass="56981" checksum="275636924556ACFA" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIQ6</accession>
    <name>W4KIQ6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_432369</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542562.1">
        <property type="nucleotide sequence ID" value="XM_009544267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIQ6"/>
    <dbReference type="STRING" id="747525.W4KIQ6"/>
    <dbReference type="GeneID" id="20674607"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_432369"/>
    <dbReference type="eggNOG" id="KOG0037">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051357_1_0_1"/>
    <dbReference type="InParanoid" id="W4KIQ6"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16180">
        <property type="entry name" value="EFh_PEF_Group_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051426">
        <property type="entry name" value="Peflin/Sorcin_CaBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212:SF3">
        <property type="entry name" value="GH27120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212">
        <property type="entry name" value="PEFLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="46"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="113"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="185"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW85732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="220" mass="24472" checksum="A8F23706FE278200" modified="2014-03-19" version="1">MAYYSNPNYNSGHRHSVSSGHHHHNHSPAPPGYSGGGYGYQQPPLGADPQLWQWFSAVDADRSGAISANELQSALVNGNWSGFDLDTVKMLMNIFDTDRSGTIGFNEFSGLWKYISDWQNVFKHFDKDRSGTIDGYELAEALRSFGYNLAPSILTLIEQKYATGPSTGYGPPPGITFDRFVRACVAVKSLTESFQRVDTDRDGWVTINYEDFMKIVLNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIY1</accession>
    <name>W4KIY1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_379932</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542620.1">
        <property type="nucleotide sequence ID" value="XM_009544325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIY1"/>
    <dbReference type="FunCoup" id="W4KIY1">
        <property type="interactions" value="339"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KIY1"/>
    <dbReference type="GeneID" id="20671995"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_379932"/>
    <dbReference type="eggNOG" id="KOG2085">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012437_1_1_1"/>
    <dbReference type="InParanoid" id="W4KIY1"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901991">
        <property type="term" value="P:negative regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000016">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="519"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="565"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW85798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="576" mass="66433" checksum="DBA4A206D29EB068" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJS7</accession>
    <name>W4KJS7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_414588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542427.1">
        <property type="nucleotide sequence ID" value="XM_009544132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJS7"/>
    <dbReference type="GeneID" id="20673188"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_414588"/>
    <dbReference type="eggNOG" id="ENOG502RD68">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_208061_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJS7"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="63" mass="6771" checksum="5E4244A55C4BE6F9" modified="2014-03-19" version="1">MVVKGPNPALFAGVALLSFGAFYFLVNHRAVTAPASARPRPNDHPLVPPIHSEEADKPNPRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKC7</accession>
    <name>W4KKC7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_310165</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. Plays a role in both tRNA-processing and mitochondrial metabolism. Involved in the 2-thio-modification of both 5-carboxymethylaminomethyl-2-thiouridine in mitochondrial tRNAs and 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) in cytoplasmic tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(sulfur carrier)-H + L-cysteine = (sulfur carrier)-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542944.1">
        <property type="nucleotide sequence ID" value="XM_009544649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKC7"/>
    <dbReference type="FunCoup" id="W4KKC7">
        <property type="interactions" value="547"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KKC7"/>
    <dbReference type="GeneID" id="20669755"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_310165"/>
    <dbReference type="eggNOG" id="KOG1549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_0_2_1"/>
    <dbReference type="InParanoid" id="W4KKC7"/>
    <dbReference type="OrthoDB" id="10250117at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000003">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000002">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00331">
        <property type="entry name" value="Cys_desulf_IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02006">
        <property type="entry name" value="IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010611">
        <property type="entry name" value="PRK14012.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="12">
        <location>
            <begin position="22"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW86179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="420" mass="46472" checksum="F79A4011BD0CA06C" modified="2014-03-19" version="1">MLGFKFDMPRRESTLKDKARPIYLDMQATTPVDPRVLDAMLPYLTDQYGNPHSRTHAYGWEAEKAVEDARKHIADLIGADPKDIVFTSGATETNNMAIKGVARFHKEKKKHIITTQTEHKCVLDSCRKLQEEGFDVTYLPVQRNGIVDLKELEDAIRPDTSLISIMTVNNETGVIQPIKEIGEIARRHRGVYLHTDAAQAVGKIPVDVNEMNVDLMSISGHKIYGPKGVGAAYVRRRPRVRLEPILSGGGQERGLRSGTLPTALTVGMGEAARIAKLEMTRDHARIAQLSQRLIDSINSRVEHVVRNGDVNGFPGCVNLSFSYVEGESLLMALKDIALSSGSACTSASLEPSYVLRALGAAEDMAHSSLRFGIGRFTTEAEIDFVVEKIVATVQKLRDMSPLWEMVQEGIDINSIDWSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKH0</accession>
    <name>W4KKH0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_448635</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542413.1">
        <property type="nucleotide sequence ID" value="XM_009544118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKH0"/>
    <dbReference type="STRING" id="747525.W4KKH0"/>
    <dbReference type="GeneID" id="20675880"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_448635"/>
    <dbReference type="eggNOG" id="KOG3183">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052358_1_0_1"/>
    <dbReference type="InParanoid" id="W4KKH0"/>
    <dbReference type="OrthoDB" id="431929at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF20">
        <property type="entry name" value="ZINC FINGER AN1-TYPE CONTAINING 2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="11"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="65"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW85566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="296" mass="31602" checksum="4C4C8917381D9F0C" modified="2014-03-19" version="1">MDLALTGAAHCALPSCNELDLLPIRCICGTQYCRKHFTRDAHACPVDPAALRSTAAAAFAPLLRCALTTCSKPSLEAYTSSSTADDPERISARCPRCHLAYCATHRTPVSHSCPIPEPAPAPKDPSAHALLAKYFPSASTSTVTSKPTPPPRQRSIPTDPKKLAQLQKLELMKMRHRAVPGDPKDSTRTAVPVDQRLHVKLSPHAAESSPPGLGTSTKPESVFWFRKTTGTGRALDLLADHLHTSAPAGHFLQLAKISPTEEATVLRTDQPLVDQVEDGALLSISTIPVDASGVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKI3</accession>
    <name>W4KKI3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitochondrial ATP synthase, epsilon chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_167473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ATPase epsilon family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543070.1">
        <property type="nucleotide sequence ID" value="XM_009544775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKI3"/>
    <dbReference type="STRING" id="747525.W4KKI3"/>
    <dbReference type="GeneID" id="20668119"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_167473"/>
    <dbReference type="eggNOG" id="KOG3495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_187039_0_1_1"/>
    <dbReference type="InParanoid" id="W4KKI3"/>
    <dbReference type="OrthoDB" id="269124at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12153">
        <property type="entry name" value="F1-ATPase_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.20:FF:000004">
        <property type="entry name" value="Related to atp synthase epsilon chain, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.20">
        <property type="entry name" value="ATP synthase, F1 complex, epsilon subunit superfamily, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006721">
        <property type="entry name" value="ATP_synth_F1_esu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036742">
        <property type="entry name" value="ATP_synth_F1_esu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12448">
        <property type="entry name" value="ATP SYNTHASE EPSILON CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12448:SF0">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT EPSILON, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04627">
        <property type="entry name" value="ATP-synt_Eps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48690">
        <property type="entry name" value="Epsilon subunit of mitochondrial F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW86322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="73" mass="8380" checksum="74DC72486567A81C" modified="2014-03-19" version="1">MSSASWRQFFTYNKYTQISARAVRQSLKESERLNAEKRGLTVLRYQKWENGQGGEQVFLNPPEDTKPAKSAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKV2</accession>
    <name>W4KKV2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_150126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542530.1">
        <property type="nucleotide sequence ID" value="XM_009544235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKV2"/>
    <dbReference type="GeneID" id="20667352"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_150126"/>
    <dbReference type="HOGENOM" id="CLU_1643913_0_0_1"/>
    <dbReference type="InParanoid" id="W4KKV2"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="161" mass="18058" checksum="D88EFB973C50A94A" modified="2014-03-19" version="1">MQPQTVCAMPESDLDLVVVIHAAHEFIPNAQTLWRPKTLRTARVVSTRWVRAHRRPSRRCKSALDLNDRGASPMSMVSCRSRSARDDIFPCWDYVYADQQGTARMGCCSRSARRCVLTVRCRGNLPSDPGALEMELSSETDPCYSAAMISRDKSCSQSAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKY1</accession>
    <name>W4KKY1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_247607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540500.1">
        <property type="nucleotide sequence ID" value="XM_009542205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKY1"/>
    <dbReference type="STRING" id="747525.W4KKY1"/>
    <dbReference type="GeneID" id="20669182"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_247607"/>
    <dbReference type="eggNOG" id="KOG2056">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2612478_0_0_1"/>
    <dbReference type="InParanoid" id="W4KKY1"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF45">
        <property type="entry name" value="CLATHRIN INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="79" mass="9425" checksum="B61D316D55EA3289" modified="2014-03-19" version="1" fragment="single">NRTRKGQNFNEIILCIYSQFMEKEVRQWQHIYKALQLLEYLVKHGSEHVVDDACSHISAIKMLCNFHYIDNKEKDQGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KL13</accession>
    <name>W4KL13_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_471777</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543121.1">
        <property type="nucleotide sequence ID" value="XM_009544826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KL13"/>
    <dbReference type="STRING" id="747525.W4KL13"/>
    <dbReference type="GeneID" id="20677412"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_471777"/>
    <dbReference type="eggNOG" id="KOG2893">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037132_4_1_1"/>
    <dbReference type="InParanoid" id="W4KL13"/>
    <dbReference type="OrthoDB" id="1306014at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20908">
        <property type="entry name" value="SUF4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215:SF0">
        <property type="entry name" value="BUB3-INTERACTING AND GLEBS MOTIF-CONTAINING PROTEIN ZNF207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215">
        <property type="entry name" value="ZINC FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="372"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW86379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="405" mass="43299" checksum="7EA0BF7C383F3892" modified="2014-03-19" version="1">MAKKKNKQILRPWCWYCEREFEDEKVLMQHQKAKHFKCNMCPRRLNTAGGLAVHIQQVHKLEPENLPRIENALPGRDGYEVEIFGMEGIPAPDVADYKRRKEIELGLSAGSISQPQAKRPKTENRPLSEDELKAQLEAHKALMGANEAPSVASASENQGAVYGAPPQAYAAPPAPSPISLPPMPPSMPPGAPPFFPGMPMPPGVPPGQMPFPPFPPVPGMPPGAPPFLPPAGFPGAHPMGMMPPGGFPPPPGMRLPPPGFPPFAPGASPPFQPPNMATPPISGATPMPPSASVTPNPPFVAPVPGSGISPAPSGAHRSSPPIVPPKLTLPNPSLAQTNPDLKKKTFLKYPEPNFSPDEVRAIHPKYYFAKGQLSSTSESKTDAAQGSYAQEESRGKKRARAEDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLK0</accession>
    <name>W4KLK0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Arginase/deacetylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_307854</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540723.1">
        <property type="nucleotide sequence ID" value="XM_009542428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLK0"/>
    <dbReference type="STRING" id="747525.W4KLK0"/>
    <dbReference type="GeneID" id="20669532"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_307854"/>
    <dbReference type="eggNOG" id="KOG2964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039478_1_1_1"/>
    <dbReference type="InParanoid" id="W4KLK0"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000014">
        <property type="entry name" value="Arginase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF26">
        <property type="entry name" value="GUANIDINO ACID HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844517" description="Arginase/deacetylase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW86728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="43569" checksum="981C13D8FD221DBA" modified="2014-03-19" version="1">MKLTSAFLTLALAAFAHAHPHEQALLSAPVAAADAQEAQTWLVKYGKQVDLGYTGPLSFSHLDYHRCLEDETKDFDIAVLGMPFDTAVSYRPGARFGPFGIRAGSRRQHGERAWTLSWGMDPYRLGTKVIDCGDVPLSAFDNALALDQMEVAYSTLLARPVARTLSLDPPERIFAKDGKAHPRIVTLGGDHTIVLPILRSLNKVYGPVSVIHFDAHLDTWGYLPIPGSSTDQSRITHGSFFHVAWEEGLMTNNSVHAGIRCKMAGGADITNDEDVGFKIVSTDDIDDIGINEVIRRIRERIGDSPVYLSLDIDVIDPGLAPATGTPEAGGWTVREVKRIIRGLAGLNFVGADVVEVAPAYDHADITGIAAADIIHDFLGTMLSSEPPKSRDERAPWRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLM4</accession>
    <name>W4KLM4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_432686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543011.1">
        <property type="nucleotide sequence ID" value="XM_009544716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLM4"/>
    <dbReference type="GeneID" id="20674629"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_432686"/>
    <dbReference type="HOGENOM" id="CLU_2638351_0_0_1"/>
    <dbReference type="InParanoid" id="W4KLM4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="77" mass="8619" checksum="07D862D4E40EAAAE" modified="2014-03-19" version="1">MPWRFACLSSHAASQDCSAELSLAQHLCRYAEVAMTRHGSCMPIRSVGCCTSLTSPGDRQMRYGVQKRWTRPSSRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLS2</accession>
    <name>W4KLS2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_437555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540760.1">
        <property type="nucleotide sequence ID" value="XM_009542465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLS2"/>
    <dbReference type="FunCoup" id="W4KLS2">
        <property type="interactions" value="102"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KLS2"/>
    <dbReference type="GeneID" id="20674961"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_437555"/>
    <dbReference type="eggNOG" id="ENOG502S4D6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060583_0_0_1"/>
    <dbReference type="InParanoid" id="W4KLS2"/>
    <dbReference type="OrthoDB" id="289247at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:calcium ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040250">
        <property type="entry name" value="Nucleobindin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237">
        <property type="entry name" value="NUCLEOBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237:SF20">
        <property type="entry name" value="NUCLEOBINDIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="56"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW86773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="263" mass="30107" checksum="6670AA6D50C6EBC2" modified="2014-03-19" version="1">MATEHHIDSFDLASFFQLHDLNRDGVWDTAEIEAIYGVHHVYSQKKSKDDVEHQKKADTIVQAILKAMDKDGNEKVTQKEFEAVGLAGLPSFDELGAEGHHYDVESEFFLHHEEQYHSTPETQTDESYTHPEDLEHFAQHEAIEHKEAEREAKFQGITVEEALLQHEEHEHDEAPPALVADSNDADNDTTDAAHPPTTKKIQRQTPPEKQDPAVRFRDAKAESERHGDWGSGDAGYKPPNTPSEKMRKNLPYKYKFRRSWGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMN8</accession>
    <name>W4KMN8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_468737</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540927.1">
        <property type="nucleotide sequence ID" value="XM_009542632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMN8"/>
    <dbReference type="GeneID" id="20677248"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_468737"/>
    <dbReference type="eggNOG" id="ENOG502QVC1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009416_1_0_1"/>
    <dbReference type="InParanoid" id="W4KMN8"/>
    <dbReference type="OrthoDB" id="5600212at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="19"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="692"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW86969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="741" mass="82654" checksum="2C8CA68B800E8E71" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMZ0</accession>
    <name>W4KMZ0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_307924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540432.1">
        <property type="nucleotide sequence ID" value="XM_009542137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMZ0"/>
    <dbReference type="STRING" id="747525.W4KMZ0"/>
    <dbReference type="GeneID" id="20669537"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_307924"/>
    <dbReference type="eggNOG" id="KOG3043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_2_1_1"/>
    <dbReference type="InParanoid" id="W4KMZ0"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="257" mass="28921" checksum="9C6CC2E4B6906E62" modified="2014-03-19" version="1">MSDSKVLASPPGECCTKTVQHSGTAVGVFEDLNGVNTYVSYPPTRQERYRRIIFFFADVFGPMYINNQLIMDYFASKAGYLILGPDYFEGDFVFHHYGVEPDFDLGKWVGPKREKAYQLVPTFVDAAKAKFGTTETKYAAVGYCFGGPDVLGLTATDWLAAGAIAHPAMLDEDHFANSKRPLFLSCAETDHTFPTDSRHRSEELLRDSAFKPEYHFQVFARVAHGFAIRGNPDVPHERWAKEQSANSIIGWFDRFCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KN46</accession>
    <name>W4KN46_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_305495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540490.1">
        <property type="nucleotide sequence ID" value="XM_009542195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KN46"/>
    <dbReference type="GeneID" id="20669331"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_305495"/>
    <dbReference type="eggNOG" id="ENOG502S3G3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_676251_0_0_1"/>
    <dbReference type="InParanoid" id="W4KN46"/>
    <dbReference type="OrthoDB" id="8955945at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="247"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="290"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="335"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW86471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="407" mass="45229" checksum="ABB099768BA13E0B" modified="2014-03-19" version="1">MSGQASTSTDPPSTTVQPGRGKVKLPDNYTGNRIESQKFMLQCLLLFVAESDRYKTDQDKISLVLSCMRYGTAGAWAENFLLKSVGADPPTDLGTWRDFLTKFKLQFRETGKTDKARSALMAFSQGRMTVDEYSNQFILIAADADISDKEQVPYFQCGLDPRVMDKIYDKEVQPKDTIQDWINTACEIDGRLRARSAQKAILANSTSFRSDYLNRFHTQPTVRYNSTTAPRRMNNQVVDMDIDATRKHNAESQKRKFDGKRTTPCSNCGKPGHSSANCWSPRRGVCPVRGNSKRRLGTTGRGNRAVDLEGEDDAPAMGDQAGIYRGMETEDVHRNNQWVPQPGPSMERPHSAPSGRPQTNHGQHAMLPNGRRGDGSVSHSARIGAVLGELGEDEAREVILGHAEHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KN73</accession>
    <name>W4KN73_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_99559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541103.1">
        <property type="nucleotide sequence ID" value="XM_009542808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KN73"/>
    <dbReference type="FunCoup" id="W4KN73">
        <property type="interactions" value="234"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KN73"/>
    <dbReference type="GeneID" id="20678910"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_99559"/>
    <dbReference type="eggNOG" id="KOG2317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_7_2_1"/>
    <dbReference type="InParanoid" id="W4KN73"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="126" mass="13257" checksum="C5955D9FE0781D20" modified="2014-03-19" version="1">MSTVEKINAPENPSYSHILSHATKVPGLIFLSGQTPVGADGKLVAGGIEEHTAQCIANLGNVLKAAGSSWEKVVKVNVYLKDMDNFSAMNEVYEKLLPTPKPARTCIQAAKLPGGVDVEIEAIAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNQ8</accession>
    <name>W4KNQ8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_423795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540684.1">
        <property type="nucleotide sequence ID" value="XM_009542389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNQ8"/>
    <dbReference type="GeneID" id="20673943"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_423795"/>
    <dbReference type="HOGENOM" id="CLU_327618_0_0_1"/>
    <dbReference type="InParanoid" id="W4KNQ8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="878" mass="97476" checksum="86B7F67D55D38A96" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPI3</accession>
    <name>W4KPI3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3752 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_469948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541589.1">
        <property type="nucleotide sequence ID" value="XM_009543294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPI3"/>
    <dbReference type="GeneID" id="20677313"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_469948"/>
    <dbReference type="eggNOG" id="KOG4188">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067132_0_1_1"/>
    <dbReference type="InParanoid" id="W4KPI3"/>
    <dbReference type="OrthoDB" id="73491at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022226">
        <property type="entry name" value="DUF3752"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046331">
        <property type="entry name" value="GPAM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370:SF1">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12572">
        <property type="entry name" value="DUF3752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3752" evidence="2">
        <location>
            <begin position="138"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW87722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="300" mass="33376" checksum="382714D17E636734" modified="2014-03-19" version="1">MASIGPYVPPSLSNSPAAPSTAPSVGLLQRYEEEEEEEEDDYAPALPPDLAAARINGGGPATVGPSRRIFGPSMGPQRQEEEESEDEEVGPAPLPSSATLDPQDGIREFREKEEQRRKHIEEAAKPKALQREEWMLVPPSSSDLLGTLDPTKLSKPRQFSRSTAPARKVDNSLWTETPAERQQRLADEVLGKKRRIENADATEGDEDEARKKRKRDAEIRREVEEHTRKHRGSSLLDAHADADSRKKKDDDGEGPPAIWDHSRDMSLGGRLMDEKDRQKMIRDARGLSDRFGTGRSGGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPL1</accession>
    <name>W4KPL1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NEDD8-conjugating enzyme UBC12</fullName>
            <ecNumber evidence="7">2.3.2.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NEDD8-conjugating enzyme Ubc12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">RUB1-conjugating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin carrier protein 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HETIRDRAFT_377720</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.34" evidence="7"/>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540947.1">
        <property type="nucleotide sequence ID" value="XM_009542652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPL1"/>
    <dbReference type="FunCoup" id="W4KPL1">
        <property type="interactions" value="887"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KPL1"/>
    <dbReference type="GeneID" id="20671900"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_377720"/>
    <dbReference type="eggNOG" id="KOG0420">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_6_0_1"/>
    <dbReference type="InParanoid" id="W4KPL1"/>
    <dbReference type="OrthoDB" id="10249039at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061654">
        <property type="term" value="F:NEDD8 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000005">
        <property type="entry name" value="NEDD8-conjugating enzyme Ubc12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="14">
        <location>
            <begin position="23"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="12">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETW86991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="178" mass="20366" checksum="0CE66795E9F78199" modified="2014-03-19" version="1">MIKIWSMKKNEDAAAKKKPKTSAAQIRVQKDLTELDLPPTMKTYFPDPSNLLNFTLTISPDEGMYKGGAFVFSFVINTNYPHEPPKVKCTQTIYHPNVDLEGNVCLNILREDWKPVLNLNSVMVGLQYLFLEPNADDPLNKEAAEDLRRNRDQFIHNVMASMRGGYVKGVQYDKVFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPT5</accession>
    <name>W4KPT5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_114757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541660.1">
        <property type="nucleotide sequence ID" value="XM_009543365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPT5"/>
    <dbReference type="STRING" id="747525.W4KPT5"/>
    <dbReference type="GeneID" id="20666453"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_114757"/>
    <dbReference type="eggNOG" id="ENOG502T20M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_30_1_1"/>
    <dbReference type="InParanoid" id="W4KPT5"/>
    <dbReference type="OrthoDB" id="3049938at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW87802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="19771" checksum="0B7002D00F78DE08" modified="2014-03-19" version="1">MSDKGNKPKDFNGTRSKYKEWIYECHMYILTNPTKYDTDKDKTLMVLSYMREGTASLFAQKYYFDRELREYKATETKKTWGTFKDFLKELAATFKDESLEQKARQKLFTMRMGKRLADEFVTDYLMTAGESGFDLKSTVNYFRRAIHPEILKQIYRLPDMPTTMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W4KQJ6</accession>
    <name>W4KQJ6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_145420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541223.1">
        <property type="nucleotide sequence ID" value="XM_009542928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KQJ6"/>
    <dbReference type="GeneID" id="20667081"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_145420"/>
    <dbReference type="HOGENOM" id="CLU_2886060_0_0_1"/>
    <dbReference type="InParanoid" id="W4KQJ6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW87306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="63" mass="7480" checksum="5574E539F8C77987" modified="2014-03-19" version="1" fragment="single">MQIFVSFSYKRLSSTMKVSNMPALQFGGVRKESWKVPDVPSGLQSHCVFICHRARRFRRLYQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMY5</accession>
    <name>W4JMY5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_412780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553358.1">
        <property type="nucleotide sequence ID" value="XM_009555063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JMY5"/>
    <dbReference type="STRING" id="747525.W4JMY5"/>
    <dbReference type="GeneID" id="20673070"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_412780"/>
    <dbReference type="HOGENOM" id="CLU_2904455_0_0_1"/>
    <dbReference type="InParanoid" id="W4JMY5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004843777" evidence="2">
        <location>
            <begin position="19"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW74893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="62" mass="7373" checksum="474E712B57DCFECE" modified="2014-03-19" version="1">MMLVVLCLTVSVLLYIRGRWVERLRREERQQQNEGQVQQQEDRGLPVPLRGDPARDDWAVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMZ2</accession>
    <name>W4JMZ2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Esterase/lipase/thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_57468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553068.1">
        <property type="nucleotide sequence ID" value="XM_009554773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JMZ2"/>
    <dbReference type="FunCoup" id="W4JMZ2">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JMZ2"/>
    <dbReference type="ESTHER" id="9agam-w4jmz2">
        <property type="family name" value="Hormone-sensitive_lipase_like"/>
    </dbReference>
    <dbReference type="GeneID" id="20678396"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_57468"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_6_3_1"/>
    <dbReference type="InParanoid" id="W4JMZ2"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="34"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW74927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="279" mass="30537" checksum="95C143D7CCE1B605" modified="2014-03-19" version="1" fragment="single">VQDHQVPVGGQARILARCVVPTPANARGKTFPLLVWYHAGGFISGYAAMDDYILRHICVELQISIVNVDYRLAPEFPFPTGINDSYAALKWAVQNVALLSANLSKGFIVSGLSAGGTIAAVMALRARDDPFFRSYPLTGQILHSPATIHPAAYPDRQAKIAIFYSSLSFTHAPILPGRALAWFYGLVKAPPADPDFSPLLASEHAGLPPLWMQLAGMDPLRDEALLYEKVLRTSGVQTKLHVYPGVPHAFEFVFPKLSISIQFRSDFRDGIKWLLALSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4JN41</accession>
    <name>W4JN41_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein RER1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_461497</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RER1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553355.1">
        <property type="nucleotide sequence ID" value="XM_009555060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JN41"/>
    <dbReference type="FunCoup" id="W4JN41">
        <property type="interactions" value="506"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JN41"/>
    <dbReference type="GeneID" id="20677175"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_461497"/>
    <dbReference type="eggNOG" id="KOG1688">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074889_0_0_1"/>
    <dbReference type="InParanoid" id="W4JN41"/>
    <dbReference type="OrthoDB" id="448250at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004932">
        <property type="entry name" value="Rer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743:SF0">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03248">
        <property type="entry name" value="Rer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016013">
        <property type="entry name" value="AtER_Rer1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW74889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="199" mass="23488" checksum="7BFEB2594E4544C6" modified="2014-03-19" version="1">MMNSEPSDLPGPLQSFSGTYARLQRQYQHQLDRATPHILYRWLATVGIVSLFELRIVLAQGWYIVCYAHAIYILNLLLAFLQPKFDPSLQDDLMADEIEEGGAEGERSPLPSARDDEFRPFVRRLPEWQFWLSTTRATIISFFMTFSVVFDVPVYWPILVMYFFVLFILTMRRQIQHMIKYRYVPFDWGRKARYGASNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4JN82</accession>
    <name>W4JN82_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF300-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_237093</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553450.1">
        <property type="nucleotide sequence ID" value="XM_009555155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JN82"/>
    <dbReference type="STRING" id="747525.W4JN82"/>
    <dbReference type="GeneID" id="20668768"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_237093"/>
    <dbReference type="eggNOG" id="KOG2641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034016_0_0_1"/>
    <dbReference type="InParanoid" id="W4JN82"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="407"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW74998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="55132" checksum="6899BB0F0E76C205" modified="2014-03-19" version="1" fragment="single">HHVGWIICGFFTIVSSITSFWLINKHLQWYTNKHEQRHIVRILFMVPIYAVISLASYLFWDNSTPLLLIRDCYESVVLTAFFYLLLTYLSPNIEEQKDIFRKEGLSREHDMELMARGEKPGKWAFPLFFVRWKPQDGLYFLQLMKWGVLQYCVIRPTTTLAAVVLNYAGLYCEESWSPAWGHVYISALISASVSIAMYCLLQLYFCVSKQLSPQRPVLKLFAVKAVVFLTFWQASALSLLSMIGVVKDTPYMTAEDINIGWGALLETLEMMIFAFVHIRAFSYMPYRSDTEQTPRLRALRHAMDFRETFRELTNGCVYIWHRMRGIETDTRARREAVLEGAFGQSRTQVWRARDKEKDTIGVEVDVEVDRLVMVEGERQWLGIGDNYGYGLMRRERSDGLEEQIDKELSKRGYAKPGHRSQEDPGDPGEGHARGRRSWWRSVYDRVSQSGPDHDNTRFTPIPKRNRSRLQRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPA5</accession>
    <name>W4JPA5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_331559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552789.1">
        <property type="nucleotide sequence ID" value="XM_009554494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPA5"/>
    <dbReference type="GeneID" id="20671668"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_331559"/>
    <dbReference type="HOGENOM" id="CLU_2967248_0_0_1"/>
    <dbReference type="InParanoid" id="W4JPA5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW75363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="49" mass="5969" checksum="756FEB7CF57E651B" modified="2014-03-19" version="1" fragment="single">FVLVIHLFEESRYPFQHTRYWYLYSRFLPLRISLTLYSSCPFMRSGGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQ35</accession>
    <name>W4JQ35_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Choline dehydrogenase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">chd3</name>
        <name evidence="10" type="ORF">HETIRDRAFT_152387</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551942.1">
        <property type="nucleotide sequence ID" value="XM_009553647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQ35"/>
    <dbReference type="GeneID" id="20667409"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_152387"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_0_1"/>
    <dbReference type="InParanoid" id="W4JQ35"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="9">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="492"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="535"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW75677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="555" mass="60650" checksum="A9ACAF856A0F4E8B" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQK6</accession>
    <name>W4JQK6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_330784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552786.1">
        <property type="nucleotide sequence ID" value="XM_009554491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQK6"/>
    <dbReference type="GeneID" id="20671615"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_330784"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_6_4_1"/>
    <dbReference type="InParanoid" id="W4JQK6"/>
    <dbReference type="OrthoDB" id="2630497at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46148">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46148:SF52">
        <property type="entry name" value="OS04G0603800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="1">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="110" mass="13273" checksum="1A04E848A1B5A17A" modified="2014-03-19" version="1" fragment="single">LEGTHIWMTHPKFKLAPRRYGLFRILSKVGLLVYKLQIPQHWKIHPVFHATMLTKYKKKEAHRTNFVKPLLEVLNDKEHYKVEMILDLKQQECRTKYLVNWEGYLKADNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRM1</accession>
    <name>W4JRM1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_455747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552429.1">
        <property type="nucleotide sequence ID" value="XM_009554134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRM1"/>
    <dbReference type="GeneID" id="20676660"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_455747"/>
    <dbReference type="HOGENOM" id="CLU_1038507_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRM1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="268" mass="29060" checksum="D19E223919798DCD" modified="2014-03-19" version="1">MQIAPGHIVRDFSTASAYQPDPDDISVSLATCAPLPALSEPLPTSASCPPPATTEHRELLRRAVPVLQRRCARRQLGSRGAVPARTDAHPIPHLQVAAGFKSRGSGRARLQPGRASVRVERSSLADAREQLLWDAGRPRARAHDELRFVLHLGMPLSASTMPPRPSFPEPEQRAIACCVRRALERVESPCATAASTRRTGVVDAVVARGAGTLASGSPWPEALRDGHCLGAVDERSLSSTRRRRPARKVPVWQQRGALFDARLRGFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4JS43</accession>
    <name>W4JS43_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_411809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551295.1">
        <property type="nucleotide sequence ID" value="XM_009553000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JS43"/>
    <dbReference type="STRING" id="747525.W4JS43"/>
    <dbReference type="GeneID" id="20672973"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_411809"/>
    <dbReference type="eggNOG" id="ENOG502SSWG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_156014_0_0_1"/>
    <dbReference type="InParanoid" id="W4JS43"/>
    <dbReference type="OrthoDB" id="2505950at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW76377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="150" mass="16683" checksum="8F3AAE488AD7CCB6" modified="2014-03-19" version="1">MEPYLYLALARLSPWPSFLHTVRRYSRIDLFSLVLTITFFLGAIAGIVLFVRRISEFVNATKASLQEKGWTVSNQGVSVRTSKRLDREDYIDATQRGIMKVVGASKFGHAASASTTSLDGEDRANADGSSNKNGGTERKKRSLLRRNKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSJ2</accession>
    <name>W4JSJ2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein FRA10AC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_480555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551332.1">
        <property type="nucleotide sequence ID" value="XM_009553037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSJ2"/>
    <dbReference type="STRING" id="747525.W4JSJ2"/>
    <dbReference type="GeneID" id="20677922"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_480555"/>
    <dbReference type="eggNOG" id="KOG1297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061714_2_1_1"/>
    <dbReference type="InParanoid" id="W4JSJ2"/>
    <dbReference type="OrthoDB" id="197967at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019129">
        <property type="entry name" value="Folate-sensitive_fs_Fra10Ac1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09725">
        <property type="entry name" value="Fra10Ac1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="28476" checksum="B4E8871981C3C0A1" modified="2014-03-19" version="1">MTSYNHRTASGSASLGTTTEFEILRASHKFLREDDAENLDWNEQLARKYYSSLFREFALCDLKHYKTGNFALRWRTEGEVLSGAGETTCGNSRCRHHAPPDHDPDSIPSTSLKTLELPFAYEEHGEMKSALVKVVLCDKCCKKLMWKRNKEKEEIMKLASSSSSKEAERAKERKPPQDPSARGDWDERPVHREDQIGDRIGGEEEEKESGRQLYRHGRRSRSQSPTEKSASHRSHRRRSRSPRSRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTG9</accession>
    <name>W4JTG9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cellulose expressed protein 1, hypothetical</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cep1</name>
        <name evidence="3" type="ORF">HETIRDRAFT_106207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551687.1">
        <property type="nucleotide sequence ID" value="XM_009553392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTG9"/>
    <dbReference type="GeneID" id="20666141"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_106207"/>
    <dbReference type="eggNOG" id="ENOG502TAEM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180079_2_0_1"/>
    <dbReference type="InParanoid" id="W4JTG9"/>
    <dbReference type="OrthoDB" id="2131339at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021331">
        <property type="entry name" value="Hva1_TUDOR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11160">
        <property type="entry name" value="Hva1_TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hypervirulence associated protein TUDOR" evidence="2">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW76818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="74" mass="8090" checksum="209E6B9F9E727C8C" modified="2014-03-19" version="1">MTDQIKEGDDVSWKWGGANPSGKVDEIVEEGKAQVKSNKGNTITRTAREGDPAVKITRKGNDVVKLAHELNEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTK9</accession>
    <name>W4JTK9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_148183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551761.1">
        <property type="nucleotide sequence ID" value="XM_009553466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTK9"/>
    <dbReference type="GeneID" id="20667257"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_148183"/>
    <dbReference type="HOGENOM" id="CLU_1154040_0_0_1"/>
    <dbReference type="InParanoid" id="W4JTK9"/>
    <dbReference type="OrthoDB" id="3052275at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="241" mass="27482" checksum="89E649F2284DCB67" modified="2014-03-19" version="1" fragment="single">MSPIEPKSIRFYDKTPPTLKPLADGPHFWLFDKENPIGYDGRAGLSIDRIVKLIQSHNSYDIQPLLIPEDWKNGDPNANVPPVIVTLQNSLCHYIDHLHTIWDETPVEFYKPRSYFSTIPYPFPNVTLHELRDPKDMLYSVEWTILKILSKAHMGMVQYSTLGVKTFYNALLPAICHQIRGCEVLRSTTITFPRYSAEYGSSTCLDFVCRPSIDNLPRGLPSGFVPVLFAAHHLDALHPFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUJ1</accession>
    <name>W4JUJ1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_421989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551441.1">
        <property type="nucleotide sequence ID" value="XM_009553146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUJ1"/>
    <dbReference type="GeneID" id="20673769"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_421989"/>
    <dbReference type="HOGENOM" id="CLU_3143264_0_0_1"/>
    <dbReference type="InParanoid" id="W4JUJ1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="49" mass="5438" checksum="E041D80292F213B3" modified="2014-03-19" version="1">MTTYYIKTTYSTVSVRFVCTFSALGCSIVNLCLLPMSTCLSLTSRFSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUT5</accession>
    <name>W4JUT5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_480809</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551544.1">
        <property type="nucleotide sequence ID" value="XM_009553249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUT5"/>
    <dbReference type="STRING" id="747525.W4JUT5"/>
    <dbReference type="GeneID" id="20677932"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_480809"/>
    <dbReference type="eggNOG" id="ENOG502QVGN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_10_1_1"/>
    <dbReference type="InParanoid" id="W4JUT5"/>
    <dbReference type="OrthoDB" id="407275at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004843835" description="FAD-binding PCMH-type domain-containing protein" evidence="6">
        <location>
            <begin position="26"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="58"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
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            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
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                <person name="Raffaello T."/>
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                <person name="Velez H."/>
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                <person name="Wiebenga A."/>
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                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
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            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_328916"/>
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    <feature type="non-terminal residue" evidence="2">
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="120" mass="13789" checksum="E8B67407EF32087C" modified="2014-03-19" version="1" fragment="single">QILEFFFIKLALFWLQIEVVVAQDLENLVQDLDVFCHVFGKDEDVVHIYGYFPGRDELPEDHVHHGLEVGKAEEHHRGFVRAQRSDESCLPLVALLDSYIVVSPPYIQFAENGGPFDHVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
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                <person name="James T.Y."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
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                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_429724"/>
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    </feature>
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    </feature>
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        </location>
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        </location>
    </feature>
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            <end position="186"/>
        </location>
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        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="797" mass="86346" checksum="7640FB0E4E02D2CB" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVF6</accession>
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            <taxon>Bondarzewiaceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JVF6"/>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_454820"/>
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    <dbReference type="InParanoid" id="W4JVF6"/>
    <dbReference type="Proteomes" id="UP000030671">
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    </dbReference>
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        <location>
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            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
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            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="117" mass="12283" checksum="AB4DB3445B2E9514" modified="2014-03-19" version="1">MLCERSGGGEDDDDDDGGGGEGKESGMVFRDKPPALALRLGRAGFDRDRGRQARSLGSVTARPSPPPPPSLSSPSGPVQPPSHQPASEQTLHDIWPGFHCLAQRSLSLATRNTPAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVX7</accession>
    <name>W4JVX7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS15 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
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        <lineage>
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            <taxon>Heterobasidion</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549671.1">
        <property type="nucleotide sequence ID" value="XM_009551376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JVX7"/>
    <dbReference type="FunCoup" id="W4JVX7">
        <property type="interactions" value="450"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JVX7"/>
    <dbReference type="GeneID" id="20678797"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_67127"/>
    <dbReference type="eggNOG" id="KOG0400">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090139_1_0_1"/>
    <dbReference type="InParanoid" id="W4JVX7"/>
    <dbReference type="OrthoDB" id="623277at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.130:FF:000001">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_uS15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006331">
        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW77702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="151" mass="16968" checksum="F6CEE9326409EF0A" modified="2014-03-19" version="1">MGRMHAPGKGISSSALPYRRAPPSWLKTTPDDVVEHIAKLARKGLTPSQIGVTLRDSHGIPQVRFVTGNKILRILKSNGLGPSIPEDLWHLVKKAVAVRKHLETNRKDKDSKFRLILIESRIHRLARYYKTKQQIPPTFKYDSATASTLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWA0</accession>
    <name>W4JWA0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="14">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HETIRDRAFT_67199</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="14"/>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549674.1">
        <property type="nucleotide sequence ID" value="XM_009551379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWA0"/>
    <dbReference type="STRING" id="747525.W4JWA0"/>
    <dbReference type="GeneID" id="20678800"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_67199"/>
    <dbReference type="eggNOG" id="KOG2204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003818_0_2_1"/>
    <dbReference type="InParanoid" id="W4JWA0"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF101">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 14 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004843921" description="alpha-1,2-Mannosidase" evidence="15">
        <location>
            <begin position="22"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="325"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETW77812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="523" mass="57805" checksum="3FDFCAB2268ED4B9" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWP9</accession>
    <name>W4JWP9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_453976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549896.1">
        <property type="nucleotide sequence ID" value="XM_009551601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWP9"/>
    <dbReference type="GeneID" id="20676455"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_453976"/>
    <dbReference type="HOGENOM" id="CLU_2455006_0_0_1"/>
    <dbReference type="InParanoid" id="W4JWP9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="89" mass="9935" checksum="3E3633592A09A726" modified="2014-03-19" version="1">MVHGASRPTTTTHINNASSYSAQRRLAPAAHTYAQERAPQVAKFHMSRAPKEADVTPGPVLPSWECRDLPRLWDKEGRWAEGPRALQMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWU7</accession>
    <name>W4JWU7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_157372</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549944.1">
        <property type="nucleotide sequence ID" value="XM_009551649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWU7"/>
    <dbReference type="STRING" id="747525.W4JWU7"/>
    <dbReference type="GeneID" id="20667722"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_157372"/>
    <dbReference type="eggNOG" id="ENOG502S3QU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043701_0_0_1"/>
    <dbReference type="InParanoid" id="W4JWU7"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071818">
        <property type="term" value="C:BAT3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047154">
        <property type="entry name" value="UBL4A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46555">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46555:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="63"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW77929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="282" mass="30527" checksum="461E489EAEA19027" modified="2014-03-19" version="1">MADQAELAFVKNFINTLASQPIVFNDDFQQPPENTLKRVPVLQVEVPSPPERKVDLAESVGILQVTFKSLKPPFSISVSVSPADPISSIKTQIAAEPRAPPADAQRLLFKGKALADAKLLKEYTIKDGDIVNLMVKPGFEWDPSKESLKEPASEGTSDARLSPNPSGKKRGHGRIPSVVLSPTPSSPSDKPQDIPLVLDTGITLSADMPSESSPLPQSTYRSIISKPEFWEKLHFFLSGEFHTRSDASTAFEDFLNASKGVLTVSEIAKIRDHVGVVGMAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4JX03</accession>
    <name>W4JX03_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_421727</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551095.1">
        <property type="nucleotide sequence ID" value="XM_009552800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JX03"/>
    <dbReference type="GeneID" id="20673744"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_421727"/>
    <dbReference type="eggNOG" id="ENOG502QU1B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_4_0_1"/>
    <dbReference type="InParanoid" id="W4JX03"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845037" description="FAD-binding PCMH-type domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="115"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW77615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="563" mass="61530" checksum="0370CFD8876E43CB" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4JX18</accession>
    <name>W4JX18_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PITH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_325322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550009.1">
        <property type="nucleotide sequence ID" value="XM_009551714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JX18"/>
    <dbReference type="GeneID" id="20671138"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_325322"/>
    <dbReference type="eggNOG" id="KOG1730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072377_2_1_1"/>
    <dbReference type="InParanoid" id="W4JX18"/>
    <dbReference type="OrthoDB" id="2635at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF1">
        <property type="entry name" value="PITH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="2">
        <location>
            <begin position="12"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW78004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="209" mass="22867" checksum="F46FB35BEC6D1E77" modified="2014-03-19" version="1">MSDHANDGIPDFLSTSGDMTANLFGVIDRDNVHGLNLTVPEAAKDLIKPWSERESTETFADSNVDDQMIVHIPFSENVRVRSLFLKLGRGEVAPRQLRIYANHPNIIDFSEAEENKPLLNISLLEGETTVIEYPLRVAAFSSINSLSLFFGDSVGGNASRIYYIGFKGELRTSRRSGTSKLVIPAATGADASLTDRVSERAAQPQPTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXQ4</accession>
    <name>W4JXQ4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_148687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549875.1">
        <property type="nucleotide sequence ID" value="XM_009551580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXQ4"/>
    <dbReference type="GeneID" id="20667291"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_148687"/>
    <dbReference type="HOGENOM" id="CLU_2210399_0_0_1"/>
    <dbReference type="InParanoid" id="W4JXQ4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="107" mass="11927" checksum="A0640EF1BEB7C8A1" modified="2014-03-19" version="1">MQRVAPKQHITTGNPRHCNGRSNKRARHRCTSAEVTRKKQQITKNSMGTTTGSTTGRPQIRRLQLALKDTLTHHRLVSLISASYISPAFKPEGWMVLLENSVPVAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYB9</accession>
    <name>W4JYB9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CST complex subunit STN1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Suppressor of cdc thirteen homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_107707</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550101.1">
        <property type="nucleotide sequence ID" value="XM_009551806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYB9"/>
    <dbReference type="STRING" id="747525.W4JYB9"/>
    <dbReference type="GeneID" id="20666269"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_107707"/>
    <dbReference type="eggNOG" id="ENOG502RY83">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019576_0_0_1"/>
    <dbReference type="InParanoid" id="W4JYB9"/>
    <dbReference type="OrthoDB" id="77828at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018856">
        <property type="entry name" value="Stn1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF33">
        <property type="entry name" value="CST COMPLEX SUBUNIT STN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10451">
        <property type="entry name" value="Stn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="CST complex subunit Stn1 N-terminal" evidence="10">
        <location>
            <begin position="92"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="217"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="325"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="441"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="466"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW78100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="487" mass="52470" checksum="E35A74CE95317D45" modified="2014-03-19" version="1" fragment="single">MSFTSTETTPRRPKTIMLSPSKRHGAAPHPSVPSRLPRKGSILSSKGKPATPAEIWKWCLTPAAVARCFVRDACAMGEHAGEGFEYYLLGRVPCRTLLLVGVVVGLSEYESRAIYQVDDGTGVINCVVRYPALAGKAVRSEERPPPKPVAEVGQLVRLAGRIRVKGQRREVLVDQISVCKSMDEELDHWRTVIALHKESYSSTEPFVITSSLAPPAQAVKDAAKPPAGRAWHKAAPGDRDATKRQDNVEHRIIALPKDTAEKDALNAQTSRPAYVPTSPSTSAASSPTKSIHDPSSPPRLRHPSRLHSRDLTANTFRIYLKHYMDNAPPHDEPRGADLSSESDSDAFAPTTPTKRGRGTGARPRFMDECTPRARKVARGDPAPTSPGGPSRTPRAGRLAAREDAAAAGGSPLLLGFTLSYLRRVPELAVLAQRVVRAEARRREKAARGASASSGAGKDAGMGTGMDKGKGKAVEASKEGVRPKMKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYC2</accession>
    <name>W4JYC2_HETIT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_220120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009550614.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_220120"/>
    <dbReference type="eggNOG" id="ENOG502S3G3">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_068189_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF39">
        <property type="entry name" value="RETROTRANSPOSON-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="350" mass="40821" checksum="EAC1ED6C6B0ADA84" modified="2014-03-19" version="1" fragment="single">MNDRIITPIRLNVKVSNRSQYAGAKATIDSACEGVIVNETWVRRHRFPTYTLNNPIRVRNVDDTINKAGLIRSALDVNLTIQDIRGRTHTERVQMFISNLGKDDLILGTDWLKYHDPSIEWRQREVHFDRCPQKCQQPYGFTRAREEPQNNRRLSDVEPRHKPRINEREKQRLEHLRRLSEDVGLRDHSGTFGVQLRAYLKRKWLLQDIRKYAEEKRKAQAKPSLSPNGGEPDLPHKNSGKQATEEPVIRKLAPEPSGFASFDQDLEDEIVVTNLKERVPKAHHEFLDIFSERKSQRLPEHTYWDHAIDLKPTFKPQVPKIYALSPEKHDELGKFIKEHLTRGTICRSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYJ4</accession>
    <name>W4JYJ4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA primase</fullName>
            <ecNumber evidence="10">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_441443</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="10"/>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549946.1">
        <property type="nucleotide sequence ID" value="XM_009551651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYJ4"/>
    <dbReference type="FunCoup" id="W4JYJ4">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JYJ4"/>
    <dbReference type="GeneID" id="20675365"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_441443"/>
    <dbReference type="eggNOG" id="KOG2851">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028288_1_0_1"/>
    <dbReference type="InParanoid" id="W4JYJ4"/>
    <dbReference type="OrthoDB" id="19606at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04860">
        <property type="entry name" value="AE_Prim_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.920.10:FF:000003">
        <property type="entry name" value="DNA primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00335">
        <property type="entry name" value="primase_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="DNA PRIMASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3 10" id="KW-0639">Primosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW77931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="416" mass="48230" checksum="47BE39FE2CF44317" modified="2014-03-19" version="1">MDVDELDPSSPEVMLAFYRRLYPFKSIFKWLNHEHSPTRLFTNREIAYTLQSDVYLRYNSFTTVEEFKKQTCSLNPTRFEIGPVYTARPRDKKTIRPSAFLPLQRELVFDIDMTDYDSIRTCCSGAGICKRCWGFIGAAVRVLDHAIRDEFGYQHLLWVYSGRRGIHLWVSDREAMELTDEQRRAIVGHLTVIQGGQDMHKKVNVRGKKGGENILPPSVKAALETLVDVFGDLILADQDCFKKDEAWEELLELIPDKTVVAELRRKWDRDENRSSEDKWADLKAKVSGYDRKSPERAVMKAAMEDIVLQYTYPRLDAEVSKHRNHLLKAPFCVHPKTGRICVPVDPERIDDFDPGRVPTVGQLLRELDATSTESNGEEHSDWEKTSLKPYVDMFEKHIIGLMEEVRRDKRETDTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYX0</accession>
    <name>W4JYX0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_326172</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550073.1">
        <property type="nucleotide sequence ID" value="XM_009551778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYX0"/>
    <dbReference type="FunCoup" id="W4JYX0">
        <property type="interactions" value="196"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JYX0"/>
    <dbReference type="GeneID" id="20671216"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_326172"/>
    <dbReference type="eggNOG" id="KOG1756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062828_3_1_1"/>
    <dbReference type="InParanoid" id="W4JYX0"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000008">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="18"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="13">
        <location>
            <begin position="100"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW78071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="139" mass="14785" checksum="CA7B3DDCE1696151" modified="2014-03-19" version="1">MSGKVGGKSKSGKASGAEGSSKSQSRSAKAGLQFPVGRVHRLLKRGNYAQRVGAGAPVYLAAVLEYLAAEILELAGNAARDNKKQRIVPRHLQLAIRNDEELNKLLGDVVISQGGVVPFINPELLPSKTQKGKKESQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZ34</accession>
    <name>W4JZ34_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Delta(24(24(1)))-sterol reductase</fullName>
            <ecNumber evidence="16">1.3.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HETIRDRAFT_445714</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ergosterol + NADP(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:18249"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.71"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:18503"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="15">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.71" evidence="16"/>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549051.1">
        <property type="nucleotide sequence ID" value="XM_009550756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZ34"/>
    <dbReference type="FunCoup" id="W4JZ34">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JZ34"/>
    <dbReference type="GeneID" id="20675642"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_445714"/>
    <dbReference type="eggNOG" id="KOG1435">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015631_3_1_1"/>
    <dbReference type="InParanoid" id="W4JZ34"/>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000003">
        <property type="entry name" value="C-24(28) sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF31">
        <property type="entry name" value="DELTA(24(24(1)))-STEROL REDUCTASE ERG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
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        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
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            <begin position="259"/>
            <end position="278"/>
        </location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="19">
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            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="478" mass="55648" checksum="65E0F335255C47F3" modified="2014-03-19" version="1">MSAGSSATSNGQLRNRNGDAQPAKITPTDEGKKADELLDKHDTFEFGGPWGVTAMMVGFPMLMYYLWICLWFYDGQLVFPKSVDGIHPFLHEMWTHVRDDANPNVYAWKVYSGLIFYQLFLAWVMPGYQQEGLPVPSLGYKTLMYNCNALWSIYATMITAAALHYYHIFRLTEIIDNYGHIMTVAMIWGFAVSFGTYFWAVARGEQMRMSGNFIYDVFMGAALNPRIGPIDLKMWAEVRIPWVIVFFLAISGACKQYEQYGYVTPNMAFMCLATWFYLNACGKGEECIPQTWDMYHEKWGFMVIFWNFAGVPFTYVYSVVYMASHDPSKYQFSTPVYVALYSTLCTAYYIWDTAMSQKSRFKMQTQGNFKYRWTFPQLPWGTIENPEYIQTAHGNRLLISGWWRYSRKPNYVADWVQSFTWGLVVGNASPIPYFYSVFFITVLVHRCGRDFERCAKKYGKDWERYCAIVKYKFIPGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZE7</accession>
    <name>W4JZE7_HETIT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_453401</name>
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            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
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                <person name="Fossdal C.G."/>
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                <person name="Hogberg N."/>
                <person name="James T.Y."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
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                <person name="Yakovlev I."/>
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                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
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</entry>
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                <person name="Asiegbu F."/>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
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                <person name="Durling M."/>
                <person name="Gonthier P."/>
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                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
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                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
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                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
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                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_420234"/>
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    </dbReference>
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    <dbReference type="InParanoid" id="W4JZT2"/>
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    <dbReference type="Proteomes" id="UP000030671">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="77" mass="9254" checksum="C51B712934A7F441" modified="2014-03-19" version="1">MDGRIVRRAPIIDSFMLPIHEESFRPRACTKLLERRIVNIWKRVTRAMRAPERTSMLPEDFVLMNARRRSLYIKNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4K066</accession>
    <name>W4K066_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
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                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="STRING" id="747525.W4K066"/>
    <dbReference type="GeneID" id="20674283"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_428578"/>
    <dbReference type="eggNOG" id="ENOG502SKI5">
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    <dbReference type="HOGENOM" id="CLU_003292_2_2_1"/>
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    <dbReference type="OrthoDB" id="3266428at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052925">
        <property type="entry name" value="Phage_Integrase-like_Recomb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605:SF3">
        <property type="entry name" value="P CELL-TYPE AGGLUTINATION PROTEIN MAP4-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="lambda integrase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW78730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="33314" checksum="5F1CD1A599CA949C" modified="2014-03-19" version="1">MAHGWKDSTLKVYGSGLLLYHVICDAKDVPETHRALASIALLCSFLSALAGSYSPSTVENYLAGIRAWHLIHGLEWSHDTARLTSLQHGTKNLAPPSAKKTKRAPYTVTYLLQLRPYLNLSDSVHTAVWACVTALFYGIACVGELTVPSLSGFKLDIHTKTSTHGQEIYWSSEPNPTDPDAALRHHLLVKKPSPNEHLFSNTFKKERRPLLHSVFLRYIAQAAAQAGLPPLHGHSFRIGGTLEFLLRGLPFDTIQVKGRWVSNTFQAYLHCHAEIMMVHIQSNMAVHWAFVHYTLPPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W4K094</accession>
    <name>W4K094_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_445645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548862.1">
        <property type="nucleotide sequence ID" value="XM_009550567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K094"/>
    <dbReference type="GeneID" id="20675638"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_445645"/>
    <dbReference type="HOGENOM" id="CLU_1610979_0_0_1"/>
    <dbReference type="InParanoid" id="W4K094"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="165" mass="17646" checksum="EE0B86320A2223DE" modified="2014-03-19" version="1">MAGGTGARKSAMRTKCPARMAGGAGARTSARHPDPRRAHLGELLDTPEHPRLLHLVHPRTSKSSAAGVPALARGWQEGLPQARPKQAMCVLKKLLATNTVPMHSPPQKAAARYDPEPVLVDTLVSRTIPIRTTHIPALAHIWARQPSASLAGEGRPLAAHARTYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0D5</accession>
    <name>W4K0D5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_323584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548916.1">
        <property type="nucleotide sequence ID" value="XM_009550621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0D5"/>
    <dbReference type="GeneID" id="20670976"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_323584"/>
    <dbReference type="HOGENOM" id="CLU_050560_0_0_1"/>
    <dbReference type="InParanoid" id="W4K0D5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="479" mass="52596" checksum="7269947C735535CE" modified="2014-03-19" version="1">MLLHDDHDASSPSRNSSPDVVLMVANPDVERVERGTSPHRPDVGRIDRGTSPQQPGSTGVLLTPHTNNFSDDDAEDYAKFKERERTRRPSPERASRGAPRHESSDDRNQSSLGPLPVGVPPPSEGTRPSGVAGPSGFRARTTAQLPGHGEAEPIPVLSETAPPPVPTSGPIPSSMGGPTPRTDPHAGELERHADALLQRNTISAVIQMATAMALQRLANFSAGQPGNEHSDVPRRLASASLQIRTLALQTDPDTASWYAHNDGRPRALLIHPDEFSQYVNRELLPALLFGGELGNVQPSRTDPFRVVTWNVPRPGEHPTPVSNPRRVPRTIVERPPPRQREVPTAHSHTATPPSHRIRGFPLSQGNTDEEEPPVYRRNEGRRSRGNQATLGRGTTAGRSIRHRPGSPPPSARFRTNEREDNRSSRRTRRADSEARRNSSWTRSELDAWDALDDPGNYDDADPYYRPDEGGGDYQGPFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4K175</accession>
    <name>W4K175_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_453398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549126.1">
        <property type="nucleotide sequence ID" value="XM_009550831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K175"/>
    <dbReference type="GeneID" id="20676377"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_453398"/>
    <dbReference type="HOGENOM" id="CLU_521807_0_0_1"/>
    <dbReference type="InParanoid" id="W4K175"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="510"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="522" mass="55999" checksum="0E211530FB756A79" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1P8</accession>
    <name>W4K1P8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_104332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549293.1">
        <property type="nucleotide sequence ID" value="XM_009550998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1P8"/>
    <dbReference type="GeneID" id="20665989"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_104332"/>
    <dbReference type="HOGENOM" id="CLU_2236942_0_0_1"/>
    <dbReference type="InParanoid" id="W4K1P8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="105" mass="11853" checksum="4CAE2E1CABC42415" modified="2014-03-19" version="1">MSDSKVIDLDTTHSEALHNVHIHIPLEPPKILPDCHLLIADPLNVNLPTQSSALILLKPTSLHVLYVFDSDGQWLNKRFLAFLSIKTDLNYVIRTILRAYKARSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1S2</accession>
    <name>W4K1S2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein phosphatase PP2A regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_64350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548814.1">
        <property type="nucleotide sequence ID" value="XM_009550519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1S2"/>
    <dbReference type="FunCoup" id="W4K1S2">
        <property type="interactions" value="367"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K1S2"/>
    <dbReference type="GeneID" id="20678677"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_64350"/>
    <dbReference type="eggNOG" id="KOG1354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021713_3_3_1"/>
    <dbReference type="InParanoid" id="W4K1S2"/>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037309">
        <property type="entry name" value="PP2A_PR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01024">
        <property type="entry name" value="PR55_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW79046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="447" mass="51209" checksum="786456A52E9C5CEB" modified="2014-03-19" version="1">MDPDASGGWRFAQCFGDKGEVEDITEADIISTVEFDSTGNYLATGDKGGRVVLFERNDMKKGCEYKFYTEFQSHEPEFDYLKSLEIEEKINKIRWCKRQNSAHFLLSTNDKTIKLWKVFEKSLRVVSESNLTDGQRSLPPPSLKQHLRLPRMAHQDNIIAAVPRKVYSNAHAYHIHSIAVNSDQETYVSADDLRINLWNLNISDRSFNIVDIKPVNMEELTEVITAAEFHPTQCNVFMYSSSKSNIKLADMRDSALCDRHAKLFEEEEDPANRSFFSEIISSISDVKFSRDGRYILSRDYLNLKIWDVNMESRPVKTIPIHDHLRGKLCDLYENDCIFDKFECTWSGDDKHVLTGSYHNYLRIFDVETLNDVVLQADKSAFKAKKIGGPLPGNNKLGQKNGMRPGLKDAMQLETLDFNKKILHASWHPRENTIAIAATNNLFLYSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1T5</accession>
    <name>W4K1T5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_104558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549535.1">
        <property type="nucleotide sequence ID" value="XM_009551240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1T5"/>
    <dbReference type="GeneID" id="20666009"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_104558"/>
    <dbReference type="HOGENOM" id="CLU_1896487_0_0_1"/>
    <dbReference type="InParanoid" id="W4K1T5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="134" mass="14875" checksum="A584FB4B544640DA" modified="2014-03-19" version="1">MLSAHADAHSSALNSVGRPHPRDDFLLVNQFARTHRRTIEQAAYSAIRLSGHTIETFDFPSHFLSIHLKYRQDLSGNPAIAFQVLESRLSHLNVLDPQMRAQLDKSIASHDAIIEVAKKAVENLPAVAGPLTIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2A0</accession>
    <name>W4K2A0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_171993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548060.1">
        <property type="nucleotide sequence ID" value="XM_009549765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2A0"/>
    <dbReference type="GeneID" id="20668378"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_171993"/>
    <dbReference type="HOGENOM" id="CLU_2942027_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2A0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="60" mass="6920" checksum="A896F13632C8705A" modified="2014-03-19" version="1">MLWSIKQPTSSENASSSYYKPNIAIQGRRLSCVGQRYFRAKRYSLRSHTTCLVFRAVMCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2B6</accession>
    <name>W4K2B6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_322092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548075.1">
        <property type="nucleotide sequence ID" value="XM_009549780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2B6"/>
    <dbReference type="STRING" id="747525.W4K2B6"/>
    <dbReference type="GeneID" id="20670813"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_322092"/>
    <dbReference type="eggNOG" id="ENOG502SIZV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005726_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2B6"/>
    <dbReference type="OrthoDB" id="6511194at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="252" mass="28367" checksum="2928DFE1BBBA20C6" modified="2014-03-19" version="1">MGACSSVSLMVTDLISVDYGWLWLPDGVEEVQVYFKAGKVRNGYFTNSNITEHTMKAMDILSKHFPYNRHIFVFGNAKTRIKHPDDALSAQKMPKYPSKSNGPSNFGVLWDKLGANGKPVYGADRKVVREKVRMVNVMFDGHSQSLYFANGEDPDNKAGVFKGMQCWGKAKHTYQDLPPSSKEAALEQNVKTALASVLVQSIQQFSTWAQHLMDAYWKGLSGKQASWAAKRYHGHCRLPDSILEQLDEHHIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2E1</accession>
    <name>W4K2E1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_48830</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547928.1">
        <property type="nucleotide sequence ID" value="XM_009549633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2E1"/>
    <dbReference type="GeneID" id="20678086"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_48830"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_3_1"/>
    <dbReference type="InParanoid" id="W4K2E1"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF78">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="16"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW79972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="530" mass="58927" checksum="4CA8720228E97794" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2V5</accession>
    <name>W4K2V5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_453057</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548588.1">
        <property type="nucleotide sequence ID" value="XM_009550293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2V5"/>
    <dbReference type="GeneID" id="20676340"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_453057"/>
    <dbReference type="eggNOG" id="KOG0527">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_645656_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2V5"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="42"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="42"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="104"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="157"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="253"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW80064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="425" mass="46897" checksum="AB70A1EC13915E08" modified="2014-03-19" version="1">MSTSVPTLAPLPSSSSATGNANSKPKRRRSNPKDDNPNQENPPRPRNSFFLFFAEKRGARPDKMPLSSYARQTGLEWRALPPEEREVYEKRAEQEKLEHARMYPEYRYKPRKGGTKRAAWGTRAQKRARKSTTSPSKGPSLSLTLPPVEAVVHPVQHTCPGNLSQSSGFNGNGPADDQPTVDPSANLFSPEQHELLNRTVEGFYVSDYSPPLIPEVDAAVRYSPMSQVEQIWHHLITEPLVLHQSFASSSSQSSLSSCSQSPLSSVSQSPFSSSSQSPPTSPSLSFTSEMGINSFHHSHLPSSNWDSFPPEEMYPPFMGSLEDFIGHAPLPPHHDSHPSSLTSSVLDTDPLPTQYFHTSDPAELLNAEVMYQNSELPESLPAENQPIADLFSELYPWAVPEYSVDSGVFAPGYGPEPSFIGTWSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4K403</accession>
    <name>W4K403_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_21171</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546881.1">
        <property type="nucleotide sequence ID" value="XM_009548586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K403"/>
    <dbReference type="FunCoup" id="W4K403">
        <property type="interactions" value="213"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K403"/>
    <dbReference type="GeneID" id="20668637"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_21171"/>
    <dbReference type="eggNOG" id="KOG3662">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011607_0_1_1"/>
    <dbReference type="InParanoid" id="W4K403"/>
    <dbReference type="OrthoDB" id="5977743at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF4">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="49"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW80542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="379" mass="43036" checksum="F5D94F9BD896AC02" modified="2014-03-19" version="1" fragment="single">LLSRANRISLVRYMWFLVVLWCELGIFYYSTATCTWPEPAHRSGARSQRILIVADPQVLNHDSYPGRNPWLMSLSQYIVDLNLRKSWRAAKATRPDAVVFLGDMMDNGRDDFRYNAYLHRFYNIFSPISTAPIYYLPGNHDVGIGATADKKKMARLRYMSNFGPLNQHVSLANHSLVLIDAPILVEEDRVRKQQGQEGTQWLPKELKEAKFIHSLNSGGNLPRKPLILFSHIPLSRPEGASCGPLREKGWIRAGRGAGYENTLSQATTNMLLETFRPSLVFSGDDHDYCEYTHRLRIEDDSPITPTEVREVSVKSFSMAMGIARPGFHLLSLSPSGPPYSQQDDAPLSTFADRPCFLPNQLSIYIWIYLPLFLLTLCVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>W4K435</accession>
    <name>W4K435_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="10">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_434634</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="10"/>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547309.1">
        <property type="nucleotide sequence ID" value="XM_009549014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K435"/>
    <dbReference type="FunCoup" id="W4K435">
        <property type="interactions" value="911"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K435"/>
    <dbReference type="GeneID" id="20674763"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_434634"/>
    <dbReference type="eggNOG" id="KOG0376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_5_2_1"/>
    <dbReference type="InParanoid" id="W4K435"/>
    <dbReference type="OrthoDB" id="445564at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07417">
        <property type="entry name" value="MPP_PP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041753">
        <property type="entry name" value="PP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="112"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="12">
        <location>
            <begin position="324"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW80577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="541" mass="60578" checksum="43F88B7B0BA42A8C" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4K490</accession>
    <name>W4K490_HETIT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_386615</name>
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    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_396921_0_0_1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="694" mass="78572" checksum="8297FC9F4272B3C1" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4K569</accession>
    <name>W4K569_HETIT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_169633</name>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_169633"/>
    <dbReference type="HOGENOM" id="CLU_3050579_0_0_1"/>
    <dbReference type="InParanoid" id="W4K569"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW80889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="54" mass="6147" checksum="3DB8DE8F6BC9D0BF" modified="2014-03-19" version="1">MKGRNECKTNCPATQTESKTWDDVPGMRCRQGDSVENSKEKRVVYSLMFCEKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4K577</accession>
    <name>W4K577_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_147042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
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        <property type="protein sequence ID" value="ETW80196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009550412.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="W4K577">
        <property type="interactions" value="8"/>
    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_147042"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010119_6_1_1"/>
    <dbReference type="InParanoid" id="W4K577"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
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            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
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                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">TC 32-1</strain>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="ETW80221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="836" mass="94353" checksum="20EBAA2C70D4CC84" modified="2014-03-19" version="1"> </sequence>
</entry>
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    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
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                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
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                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
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                <person name="Raffaello T."/>
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                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="577" mass="65947" checksum="C818B75FCAD548AB" modified="2014-03-19" version="1"> </sequence>
</entry>
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    <protein>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
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                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
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                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="22463738"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_101738"/>
    <dbReference type="HOGENOM" id="CLU_1482165_0_0_1"/>
    <dbReference type="InParanoid" id="W4K699"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="182" mass="19492" checksum="7FDFCE8DBF3B4185" modified="2014-03-19" version="1">MCILGPLEIGSSTSAACKRRSPRLGRRAFVSATTSPICAVSLAAAGFHLGRKLCRAVPPTLLPTTDPSVGHARMPPRALPARPPGSLRNPHGSRARGPENALFPAGSEGSIQRRGPVPASRMRNELKTTLAVRMPSAQGNPRGIEILPSYRELLRVYRRLSRRTSSDPTKSEKKTALDLATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6T3</accession>
    <name>W4K6T3_HETIT</name>
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        </recommendedName>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546152.1">
        <property type="nucleotide sequence ID" value="XM_009547857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6T3"/>
    <dbReference type="FunCoup" id="W4K6T3">
        <property type="interactions" value="152"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K6T3"/>
    <dbReference type="GeneID" id="20670496"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_318309"/>
    <dbReference type="eggNOG" id="KOG2645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017594_4_2_1"/>
    <dbReference type="InParanoid" id="W4K6T3"/>
    <dbReference type="OrthoDB" id="415411at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009141">
        <property type="term" value="P:nucleoside triphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="50848" checksum="F0AFC910E7D74F35" modified="2014-03-19" version="1">MYVASLLPGCSKDASESAKSLHFNGQSLRSNGTHDFKRTVLLVSIDGLRADYLERDLTPHLLDISKQGLRAKSMKPIFPTLTFPNHWALMTGLYAESHGIVANNFWDKTTDSEFHYNQIASCWKPHWWFGEPMWETAGKAGVINANLMWPGPPKTMTGATPSYFLPWRDKVPLSEKLHQILSWIDLPLEERPQLIMAYEPSLDQAGHATGPYSALVNDTLRYVDTFAKDLHTGLVDRNLTNIVDIVFVSDHGMTDTSQPEFIYMDDILGEQGWASIEHEDGWPSMGLHFNSSRNAAYYLEVLRAAAASNKDKFEVFTPETMPGRYHFAHSPRIAPVYVVPKIGYVLTTRKEGDVGLTKGNHGYDNNDPSMHAMFVAHGPFSSVAKAVHQTRSRGLLSRALSRPNKGWHSTSDDTYVMNTFQNVEIYNLVMKLLGIEQVASTNGTQGFWDKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7P4</accession>
    <name>W4K7P4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_426814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546024.1">
        <property type="nucleotide sequence ID" value="XM_009547729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7P4"/>
    <dbReference type="GeneID" id="20674149"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_426814"/>
    <dbReference type="HOGENOM" id="CLU_1441223_0_0_1"/>
    <dbReference type="InParanoid" id="W4K7P4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="188" mass="20990" checksum="88FA47814A645271" modified="2014-03-19" version="1">MQLSLAHIAEERQELATHLEKSIPPIVRNDDKLRASGTTLNYCPSTLGIVRGHFWYENGIDVRNDDKLRSIRNDVKLLSLRSRDLQNDGKLFVPSSIGISCGLAAILPIVRNDIKLCAPYRIGVVVVDHDLGHQPSEMTLNYSSLFSIGIIINVILDENDADNVRNNGKLPSSSEGKAYRDSRDIVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7T3</accession>
    <name>W4K7T3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_173529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546444.1">
        <property type="nucleotide sequence ID" value="XM_009548149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7T3"/>
    <dbReference type="GeneID" id="20668451"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_173529"/>
    <dbReference type="HOGENOM" id="CLU_3125238_0_0_1"/>
    <dbReference type="InParanoid" id="W4K7T3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="50" mass="5838" checksum="EEC4FED92453A9DC" modified="2014-03-19" version="1">MLMAMSVSHMRSRSPPPARSFLLWLDTGAHRMRAKNFCILLERSLMYTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7Y5</accession>
    <name>W4K7Y5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_444789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546108.1">
        <property type="nucleotide sequence ID" value="XM_009547813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7Y5"/>
    <dbReference type="GeneID" id="20675595"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_444789"/>
    <dbReference type="eggNOG" id="ENOG502SMXE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036419_0_0_1"/>
    <dbReference type="InParanoid" id="W4K7Y5"/>
    <dbReference type="OrthoDB" id="3041043at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="285" mass="32809" checksum="9C464CF7C77FAEB7" modified="2014-03-19" version="1">MDCAERDIGRTSSFSSILSIHPIYDGIYSRLSPGARIRFGRTCRLAYNSVQDFHSRAFNINHHLRRFFDDPIAFRNMQARLAMLISGSNALQFLDSTSYPGSDLDLYVWEDSAKEVGHWLMEHERYSFAPSIDQDKNFDVASETVFTWSDNLDQSLARNDCDDYYSTQPLEWYSFIQNGPDGPLKVQIVASARSPLVTILNFHSTCVMNCIAFDAAYSLYPQATFENKRSLCMASNASRVAEFAKYERRGWQPTVFVSRRKERDIKALFHPDDTRWVCDRHSGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4K860</accession>
    <name>W4K860_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HAD-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_451607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
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        <location>
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            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW81934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="38802" checksum="38B5031A2B0B33D7" modified="2014-03-19" version="1">MSARTFHADAVLFDMDGTLTDSISAVEAAWGKVAKDIGQDPAYVIAATHGKRAVDNLAQFKPHIKAHEMDDAVQDFEETILYYADAYHRHGPGSQSNSPWTRTPMTPLTPAYSGFATPELSISPGSSAPSSRPVSRAPSMTAARRPSFGTSLGNLLSMSVMSDTDMHVFDDPIMEDVHEEMVQQEREGGLSASKPKHLEEHEFKAWQIEAASVDRSVQILPGVKRMIESIPEGRYAVATSGAKTYAYGCMTRVGIIPPPVTITADDKRLKAGKPAPDPFLLAAKCLGFDAKKCVVFEDSPSGIRAGVASGATVIAVCTSHERSKIENCGAHFIVENMQKVHCVPCEVDGELKLQFVIEP</sequence>
</entry>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
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                <person name="Broberg A."/>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Fossdal C.G."/>
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                <person name="James T.Y."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
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                <person name="Murat C."/>
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                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_168976"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="52" mass="6097" checksum="4DC8BCE7F0C60241" modified="2014-03-19" version="1">MVFIYYSAYYSQPYNLFQMSSFITTIDISSSISQGFRIDILNHVLFLLISFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9X1</accession>
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            <taxon>Bondarzewiaceae</taxon>
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            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
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                <person name="Velez H."/>
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                <person name="Wiebenga A."/>
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                <person name="Yakovlev I."/>
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            <dbReference type="PubMed" id="22463738"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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    <proteinExistence type="predicted"/>
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        <location>
            <position position="1"/>
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    </feature>
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        <source>
            <dbReference type="EMBL" id="ETW82642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="14351" checksum="DDB6240FC5132814" modified="2014-03-19" version="1" fragment="single">LVAPLLEHMITDDVERRFTAFEALQFCDDIKSRATEEDLTKSIPPHNYDRPLQVPWSSLPPDFVAQWSLWRNPPPTYLTRLLRWADAFDWGHLIIQSFRQAFRYLAGSRPAYIMGHWDYMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
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                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546726.1">
        <property type="nucleotide sequence ID" value="XM_009548431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAR1"/>
    <dbReference type="GeneID" id="20670544"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_318854"/>
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    <dbReference type="InParanoid" id="W4KAR1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
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        <location>
            <begin position="429"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="479" mass="52533" checksum="25ACA1E3AF6E9977" modified="2014-03-19" version="1">MLLHKDHDASLPSRNSSPDVVLMVSNPDIGRVDRGTSPHPSNAGRIDRGTSPHHPEPAVITLAPHLNNFSDDDAEDYAKFKERERTCRPSSQGAPRDASWNENPDDRNLPGADEVPVGVSPPATIAASIGTAGPSGLRARTAAQLPSHGETESIPVIQGATPPPVPTGGQIPRSMGRTTLGTNPHAGELERHADALLQRSTISAVIQMATAMALQQLANFAAGQPGNEHSDIPRRLASASLQIRGLALQTDPDTASWYEHNDGRPRALLIHPDEFSQYVNRELLPALLFTGELGAVQPSRTDPFRVVVWNVPRPREHPTAVPNPRRALRTVVEHPSPRPRENRPTHSNPTTSPSHRVRNFPLSHGGTDEEEPPVYRRNEGRRSRGTQATLRRGTTTGGSVRHRPGTPPPSARFRTDEGQNNRSSRRTRRADLEARRNRSWTRSELDAWDALDDPGNYDDADPYYRPDEGGDGYQGPYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAY6</accession>
    <name>W4KAY6_HETIT</name>
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        <submittedName>
            <fullName evidence="11">Mitochondrial F1F0-ATP synthase, subunit G/ATP20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_165322</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase g subunit family.</text>
    </comment>
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        <property type="protein sequence ID" value="ETW82530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="FunCoup" id="W4KAY6">
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    <dbReference type="eggNOG" id="KOG4103">
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    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ATP_synth_F0_gsu_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04718">
        <property type="entry name" value="ATP-synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
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    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW82530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="163" mass="18079" checksum="140684E85FE6021F" modified="2014-03-19" version="1">MRFSSAPLRLAKPRALARAQPKRLASSNSTEAAQKKAQEALTSAQKVAEKAWAATRSFLGPVGERFSGLLGAYRQPLTYNLSVTREVLKQIYVAERLQPPTSVSQVTSAYLTLWRRAASPSYWREVARSGEWARIGVYAAEAYGIYKIGEIIGRRSLVGYKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KB22</accession>
    <name>W4KB22_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_450396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544920.1">
        <property type="nucleotide sequence ID" value="XM_009546625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KB22"/>
    <dbReference type="GeneID" id="20676042"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_450396"/>
    <dbReference type="eggNOG" id="ENOG502SZK7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140478_0_0_1"/>
    <dbReference type="InParanoid" id="W4KB22"/>
    <dbReference type="OrthoDB" id="3250036at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="154" mass="15625" checksum="16D911F4F0E700FF" modified="2014-03-19" version="1">MSDEYGASSGYGGSLVNKSAGDSLTTEGEHRAVGEDYGGDYAMGNYPPAGDSTASGGYGSRQSPWDASRHSGAHTPARTGSGAGTPGAGERGLIDQSTSGGSLGDTLGDARQGRDEGAQEAAGRERAYGESWEGREEAREALAARYRGGTEGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KB63</accession>
    <name>W4KB63_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4939 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_451834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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            <begin position="42"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="20501" checksum="469DAC4EF7F3E890" modified="2014-03-19" version="1">MDVVTVLASSLPSYPVNASLRAACMHGTEEEDIWNETEAQWELAPQYKEPAPVIPEDSEQEETTSESDSDSPDQTPINTRNEPLADIGKVKLPDNYTGNRIESQKFMLQCLLLFAAESDRYKTDQDKISLVLSCMRYGTAGAWAENFLLKSVGADPPTDLGTWRDFLTKFKLQFRETGKTDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBE1</accession>
    <name>W4KBE1_HETIT</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_416778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545012.1">
        <property type="nucleotide sequence ID" value="XM_009546717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBE1"/>
    <dbReference type="GeneID" id="20673359"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_416778"/>
    <dbReference type="HOGENOM" id="CLU_032924_0_0_1"/>
    <dbReference type="InParanoid" id="W4KBE1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="335"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="91"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="410"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW82675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="512" mass="54510" checksum="144A1A083BCD0DFD" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBK7</accession>
    <name>W4KBK7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THUMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_316629</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545398.1">
        <property type="nucleotide sequence ID" value="XM_009547103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBK7"/>
    <dbReference type="FunCoup" id="W4KBK7">
        <property type="interactions" value="602"/>
    </dbReference>
    <dbReference type="GeneID" id="20670345"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_316629"/>
    <dbReference type="eggNOG" id="KOG3943">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039352_2_3_1"/>
    <dbReference type="InParanoid" id="W4KBK7"/>
    <dbReference type="OrthoDB" id="367221at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11717">
        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2300.10">
        <property type="entry name" value="THUMP superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="THUMP DOMAIN CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452:SF10">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="3">
        <location>
            <begin position="139"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW83114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="289" mass="32915" checksum="F9C5C16A3B621A1D" modified="2014-03-19" version="1">MSEKKRGTQANDRSRRKYRHDGTPIWGKRSIDGPGVWVSCVKGKEKQTVGELYDLFEQLASDLWPAENNAITGDGDDENPTDDIEEDLEKQIAKELASMKKPRREQMFANCQTNTPCVVFISCKSPVNPVKLVLKHIEIVENTGITQTRYTQRLTPVVGSCVVNVPEIQALFRRVLNNFISDDPEHKYRYKIELRSRNHNTLSRQILIDTIVTCVPDGYTVDLEDPDIFILVEVFKSVCGVSIVRDYYKHLKFNVMEIAKVRNETEGFKDGEGRIVKNSIAEQDDPVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBK9</accession>
    <name>W4KBK9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_107295</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545460.1">
        <property type="nucleotide sequence ID" value="XM_009547165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBK9"/>
    <dbReference type="STRING" id="747525.W4KBK9"/>
    <dbReference type="GeneID" id="20666233"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_107295"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_2_1"/>
    <dbReference type="InParanoid" id="W4KBK9"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
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        <property type="entry name" value="ADH_Zn_CS"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
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    </dbReference>
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        <property type="entry name" value="ADH_zinc_N"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ADH_ZINC"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="7"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW83178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="362" mass="39013" checksum="D682142E98A7638A" modified="2014-03-19" version="1">MSAKGYAIHDTTKWNDFKLISYDLKTAGDYDIDIAITHCGICGSDLHTIKAEWGKPDLPVIVGHEIVGTVSAVGPKVTEFKIGDRAGVVRHLASSFASPPRIALTHASEENCKNDNENYCHDLIDTYNDRYPNGDKTTGGFATAVRVHERFVFPIPDQLPSEIAAPMLCAGLTTYSPLVRNGCGPGKKVGVIGIGGLGHFAIMWAKALGAEVYALTRSTDKDDDIKKLGGDYILHTGEADFADPYRGELDIIISTANVSAGFPLKKVLTLLAVGGHLVCVGLPEEPLPEIAAFDLVNGCAIAGSYLGNKREAISMLELASKQDLRSWIEVLPMSKATEAVEKVDKGDVRYRIVLQNDIDSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBN1</accession>
    <name>W4KBN1_HETIT</name>
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        <recommendedName>
            <fullName evidence="8">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_157271</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545477.1">
        <property type="nucleotide sequence ID" value="XM_009547182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBN1"/>
    <dbReference type="STRING" id="747525.W4KBN1"/>
    <dbReference type="GeneID" id="20667712"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_157271"/>
    <dbReference type="eggNOG" id="KOG2687">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="W4KBN1"/>
    <dbReference type="OrthoDB" id="342281at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF8">
        <property type="entry name" value="KLAROID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="504"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="8">
        <location>
            <begin position="781"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="141"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="251"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="623"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW83198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1026" mass="112483" checksum="8425A8996C31E322" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KC17</accession>
    <name>W4KC17_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_409213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545668.1">
        <property type="nucleotide sequence ID" value="XM_009547373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KC17"/>
    <dbReference type="GeneID" id="20672757"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_409213"/>
    <dbReference type="HOGENOM" id="CLU_2399938_0_0_1"/>
    <dbReference type="InParanoid" id="W4KC17"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="93" mass="10704" checksum="FDC0F75C6D50D08A" modified="2014-03-19" version="1">MLQVFFDCPYPAHSRPPPATRNPQYVHHKNEISIRYTPNTHHENTRTNKTKRSKTKTDRGPDEPLLFLHAVRSLPGADATSITPPIDDPDRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4KC62</accession>
    <name>W4KC62_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_242621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545233.1">
        <property type="nucleotide sequence ID" value="XM_009546938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KC62"/>
    <dbReference type="GeneID" id="20668941"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_242621"/>
    <dbReference type="eggNOG" id="ENOG502S342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048444_2_0_1"/>
    <dbReference type="InParanoid" id="W4KC62"/>
    <dbReference type="OrthoDB" id="2152248at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16164" checksum="4576221355C9A2BB" modified="2014-03-19" version="1" fragment="single">GTARDISFVIDFLPAFLFPNEERSVTEWAVAGISLGGQTMWLAFKDDRRIRTGISILACPDNLAVIDVLGQSAHRKLVDPPAAIPDSMVSFLRMHDTVSSPYRSLGPENPFLGKSLLVIQAEDDQVAPWALAKEFVEGLELAGGRKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCD1</accession>
    <name>W4KCD1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_315329</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545645.1">
        <property type="nucleotide sequence ID" value="XM_009547350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCD1"/>
    <dbReference type="FunCoup" id="W4KCD1">
        <property type="interactions" value="256"/>
    </dbReference>
    <dbReference type="GeneID" id="20670214"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_315329"/>
    <dbReference type="eggNOG" id="ENOG502QT05">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036005_0_1_1"/>
    <dbReference type="InParanoid" id="W4KCD1"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF31">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="80"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="380"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW83389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="393" mass="43785" checksum="B2565E11077EC9A0" modified="2014-03-19" version="1">MAPVATSEHTEVASNSEKVFNPFYSPSIGDDGNDSYKWSQYKPHFPNVSWAPLQEVKVVERGLHADSAKRGLLSAASKVVHLTPAIGTELHGIDLRQLSGSQKDELALLIAERGVVFLRDQEINIHEQLDLARHYGPLHKHATTPVPKEPGLEEVHVVYNDGSRRPDPSAFTKLELWHSDVSYEIQPPSTTSLKIYTGPEYGGDTLWSSGYAVYSSLSQGFQKYLEGLTAVHSAVAQADGARAAGLPVRREPVESVHPVVRVHPATGWKSVYVNPGFTRRIVGVPKGESDAILSFLFHQLSENPDFQVRFKWTPNAIAIWDNRVVTHSATFDFWPSTRHALRATPHGERPISVAEYERDGKVAKDRQLEIWHQQGVEVPQPKEESSRARGYND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCU3</accession>
    <name>W4KCU3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_450607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545191.1">
        <property type="nucleotide sequence ID" value="XM_009546896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCU3"/>
    <dbReference type="GeneID" id="20676062"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_450607"/>
    <dbReference type="HOGENOM" id="CLU_1378284_0_0_1"/>
    <dbReference type="InParanoid" id="W4KCU3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="198" mass="21828" checksum="2FE4C9B2BF588C71" modified="2014-03-19" version="1">MSSTDSEIRHLMGIILTDAVEAMIQRIFVALIFFSTRTLLKESKTRANIVMLAITLCMFANSSTVWAVDLAGMVKVITTIQVIDPTSPPEGMPKKSSHPRSALYEVTELMLAMNVMLIASQVMYLPRSVDSSSRLMWPTSTHVAGIYPTVILLLISLKRTIWDALSLSPQATLSGIRYASIGVTEEAEDRQCRLSTSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W4KD81</accession>
    <name>W4KD81_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_47229</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543206.1">
        <property type="nucleotide sequence ID" value="XM_009544911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KD81"/>
    <dbReference type="SMR" id="W4KD81"/>
    <dbReference type="STRING" id="747525.W4KD81"/>
    <dbReference type="GeneID" id="20677450"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_47229"/>
    <dbReference type="eggNOG" id="KOG4229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036198_0_0_1"/>
    <dbReference type="InParanoid" id="W4KD81"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14879">
        <property type="entry name" value="MYSc_Myo17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036037">
        <property type="entry name" value="MYSc_Myo17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF550">
        <property type="entry name" value="MYOSIN-IIIB ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="9">
        <location>
            <begin position="18"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="123"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW83758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="613" mass="66544" checksum="5714ED51DDF0E780" modified="2014-03-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4KD82</accession>
    <name>W4KD82_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-carboxymuconate cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_315222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545331.1">
        <property type="nucleotide sequence ID" value="XM_009547036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KD82"/>
    <dbReference type="STRING" id="747525.W4KD82"/>
    <dbReference type="GeneID" id="20670200"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_315222"/>
    <dbReference type="eggNOG" id="ENOG502S2T1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037887_0_0_1"/>
    <dbReference type="InParanoid" id="W4KD82"/>
    <dbReference type="OrthoDB" id="10006285at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW83046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="32890" checksum="5F4130A5B8B0EB12" modified="2014-03-19" version="1" fragment="single">GSNTLSVFKINPTNPSQITQIGTPVSSEGEFPVSLAINKDGNQVCALNGGAVNTVNCYKVDQKLGLVAMSNTLRSLGLNQTTPATGPAGTVSHIVFSEDGKSLVASVKGVPPTPGFLAVFDVNTDGTLSAKATQIAPQKGGLLPFSMTVIPGKNAILATDAGVGFDIFDMSNIKAASSNGTKSSVVPIAGQGATCWSSFSKKTGNFYLTDIITAQVTEVNVDNNLKGTIVKQYPQGNGTATIDNDIATVGSNDFMYVLQPNSTSVAVLSLNAPGQAKNIQKLDIAGPASKVGLSISECPALDPAAPPSLTSAVCFLLLRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W4KD92</accession>
    <name>W4KD92_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_449442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543553.1">
        <property type="nucleotide sequence ID" value="XM_009545258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KD92"/>
    <dbReference type="GeneID" id="20675948"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_449442"/>
    <dbReference type="HOGENOM" id="CLU_934011_0_0_1"/>
    <dbReference type="InParanoid" id="W4KD92"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="298" mass="32503" checksum="70D7672299EC81B8" modified="2014-03-19" version="1">MAYQYEYTARLSPADLPSSMMDRARITDRNLARKLKLTPTLAPSPERSTAHNPSSRCCAGGSAACFVCGERPSPSSVRPSFAFCFSVFGFRFRPSHFVPSQFTSDFTFTFHSIASTSSRRAGSRQRAPASIATPITVLAPRLLARIRSSSSALAPPSTAVDPRPEGARPHLHTQTLSMLYVLRADACRSPIGASRIVHRASGTWQARWRAVAVRTPDRKGRSSFAASRAPRRVLVARTYFFNRAVARIEWTCQPTPARTHRLRVLLAPSARDRCGLACAARTTTNAHGPAFASGARAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4KD97</accession>
    <name>W4KD97_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_457857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543516.1">
        <property type="nucleotide sequence ID" value="XM_009545221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KD97"/>
    <dbReference type="GeneID" id="20676871"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_457857"/>
    <dbReference type="eggNOG" id="ENOG502SQ6Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027813_0_0_1"/>
    <dbReference type="InParanoid" id="W4KD97"/>
    <dbReference type="OrthoDB" id="3268221at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="97"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW83768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="450" mass="50188" checksum="BCE36ABDB62AAE63" modified="2014-03-19" version="1" fragment="single">MTSSESPPPSPILSHATRREAIHKQGRIERSSSTSNHRLSKDHGVSSNRDLARMLLHEEREAKDLRRMLLTITEQLRQESHRADENERRAKEAIFRFKAVEEARATAQAEAAKANEELRMYKLQLENAQREINKAQEILNSVEDQRYEAEASAARARTTARKLKEQRLIDLAREEGRRIGIQEGISRGRRVGFENGRVAGFEQGRSTNGGRAMFLSDEPDDTALYEPDADLEDPPLTPIDLIEEPMLNFPTPRPTAPPDPVPERISPPRSHTSSRAPSVMTQEPPSAAVLSPSSGIHPTVTHNMASPVRHPHNFIPPEGYIPRADPDSMIRLPPPHEMQRAPPTPESVLRRIPEEDFPLMIPNPSSRPYPSEASSVRRDFPHRRPISPESQGSTTISQFELVSEPSMTRPSRNRPLSTGLSVIQEVSSGYPSPANNAKSLAGDTPSRPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDW8</accession>
    <name>W4KDW8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_316068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545528.1">
        <property type="nucleotide sequence ID" value="XM_009547233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDW8"/>
    <dbReference type="GeneID" id="20670288"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_316068"/>
    <dbReference type="HOGENOM" id="CLU_003921_3_3_1"/>
    <dbReference type="InParanoid" id="W4KDW8"/>
    <dbReference type="OrthoDB" id="5599163at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="133" mass="15600" checksum="CDF43C69228D33C2" modified="2014-03-19" version="1">MATPSMPARGDRTAPTFDPHQPRELRRYFSDLDFHFVRSAVVDEQERKKHACRFLDVDTCELWESLTTFTDATKTFKEFCEEVYRLYPGSEEERKWSVSDMDKLVGKTSRVGILSLSELGDYHRRFLAITVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4KE74</accession>
    <name>W4KE74_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histidine kinase/HSP90-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_381382</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
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        <property type="protein sequence ID" value="ETW84044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543762.1">
        <property type="nucleotide sequence ID" value="XM_009545467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KE74"/>
    <dbReference type="STRING" id="747525.W4KE74"/>
    <dbReference type="GeneID" id="20672069"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_381382"/>
    <dbReference type="eggNOG" id="KOG0020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006684_1_3_1"/>
    <dbReference type="InParanoid" id="W4KE74"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000005">
        <property type="entry name" value="Heat shock protein 90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844238" description="Histidine kinase/HSP90-like ATPase domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="256"/>
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            <position position="128"/>
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        <ligand>
            <name>ATP</name>
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        </source>
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        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW84044.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="812" mass="91502" checksum="EA5AFBBFA9A8E7E1" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEU3</accession>
    <name>W4KEU3_HETIT</name>
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        <recommendedName>
            <fullName evidence="5">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <dbReference type="NCBI Taxonomy" id="747525"/>
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            <taxon>Basidiomycota</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
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            <end position="441"/>
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            <end position="164"/>
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    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="458" mass="50817" checksum="FE4DFFF4DDEE459B" modified="2014-03-19" version="1">MDAHELIDAQFDRAVEIIQSLPKTGPIQTDYEEKLMMYSLYKQATVGNVKAPRPGIWDMLGKAKWDAWAKHKDLDPYEAKWLYVDALLKVLRKYSDKTVARDLVRELESYEGDPSNIMMSRSLSRGSDSSGSGEPEQRPLVSIYRSGPLPTHLLNNTTNPQAFQRQPYPAETTSDEETSDDEARDGAPAPPTHDHHSQVNRPQSSLSSHRYRTPMAGSMMMTPPTIPVPATQPHPGFETPSAFAGPSTPSVPSLYRPQTTTSYGDQYSRERTSPQQHPHHAHSNQPTTYRATTTPLVARQHSFPVRPASRIALERAVESVQAHLAALTERIETLESHPNDAWGGYAARSPGAASASPTWPGARGIGRGSPRALGGSSWNFDEMGLWSYVLKALVRVVARSQQLVSFLADHEHRSPTLIVVRRLFLDLSFILCVLAVIRVLWRAVAGHKTPRIMVDQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
    </protein>
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        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
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        <property type="protein sequence ID" value="ETW84427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009545806.1"/>
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    <dbReference type="eggNOG" id="KOG0141">
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW84427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="516" mass="56262" checksum="5278F63C32909BAC" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4KF20</accession>
    <name>W4KF20_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycoside hydrolase family 18 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_11431</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543139.1">
        <property type="nucleotide sequence ID" value="XM_009544844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KF20"/>
    <dbReference type="STRING" id="747525.W4KF20"/>
    <dbReference type="GeneID" id="20666445"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_11431"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002833_6_2_1"/>
    <dbReference type="InParanoid" id="W4KF20"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF392">
        <property type="entry name" value="HAP41P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="1"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="246"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW83905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="378" mass="41059" checksum="6309B7C19BBA0507" modified="2014-03-19" version="1" fragment="single">LVMAYYPSWVADTFPPEKIDFGRFDWIDFAFAVPGEKFGLSWDGSDQAQSLLARLVSVAHAKGKKVKLSVGGWTGSKWFSPAVSSDTNRQTFVNNILSAYNQFNLDGIDIDWEYPGQEGAPGNRVSPDDSDNFLAFLQLLRTTLPQGARITAATQTQPFASAQGSPMANVTEFVQALDWILMMNYDVWQASSNPGPNAPLSDACQNSTQPNSNADMAIRTWTAAGFPAEKLVLGVPSYGYVSKSTATQLRTRQQPANDTDSTNNGTGTSAPQDAVHVKSEDEGQVQFRDLVVQGALCPSASPGDYDACGGFVRAWDACSNTPWLRSESAGQVISYDDARSLQMKAEMVRTHGLLGVNMFDVHGDTDEWALVDSLRKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFS2</accession>
    <name>W4KFS2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="3 10">4.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_155232</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>orotidine 5'-phosphate + H(+) = UMP + CO2</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the OMP decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="3 10"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543628.1">
        <property type="nucleotide sequence ID" value="XM_009545333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFS2"/>
    <dbReference type="FunCoup" id="W4KFS2">
        <property type="interactions" value="843"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KFS2"/>
    <dbReference type="GeneID" id="20667559"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_155232"/>
    <dbReference type="eggNOG" id="KOG1377">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030821_0_0_1"/>
    <dbReference type="InParanoid" id="W4KFS2"/>
    <dbReference type="OrthoDB" id="10263753at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04725">
        <property type="entry name" value="OMP_decarboxylase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000114">
        <property type="entry name" value="Decarboxylase,orotidine phosphate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278:SF9">
        <property type="entry name" value="URIDINE 5'-MONOPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orotidine 5'-phosphate decarboxylase" evidence="11">
        <location>
            <begin position="32"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW83896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="277" mass="30267" checksum="2251177BCEAB85D1" modified="2014-03-19" version="1">MAYLQSYAARAKNHTNPAAKQLLDTIERKKSNLCVSVDVTKSLDFLMVIDTVGPYVCLIKTHVDIIEDFDPSLIDRLVELSKKHDFLIFEDRKFADIGNTVALQYSAGVHKIASWSHITNAHPVPGPSVVTGLASVGKPLGRGLLLLAEMSTAGTLARGAYTENAVRMARNHLDFVVGFIAQRRMDGVALSDGARETTQEDFLILTPGVGLDVKGDGMGQQYRTPREVVLESGCDVIIVGRGIYGKPGSLDVSKVHAQAERYKEAGWAAYLERLQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFX5</accession>
    <name>W4KFX5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4100 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_225504</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544276.1">
        <property type="nucleotide sequence ID" value="XM_009545981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFX5"/>
    <dbReference type="GeneID" id="20668692"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_225504"/>
    <dbReference type="eggNOG" id="ENOG502SRIE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_280998_0_0_1"/>
    <dbReference type="InParanoid" id="W4KFX5"/>
    <dbReference type="OrthoDB" id="5599163at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025165">
        <property type="entry name" value="DUF4100"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13352">
        <property type="entry name" value="DUF4100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4100" evidence="3">
        <location>
            <begin position="423"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="419"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="730"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="437"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="451"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="730"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW84629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1117" mass="125075" checksum="39691BA456822086" modified="2014-03-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGK8</accession>
    <name>W4KGK8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Uroporphyrinogen decarboxylase</fullName>
            <ecNumber evidence="6 12">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HETIRDRAFT_381980</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>uroporphyrinogen III + 4 H(+) = coproporphyrinogen III + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="6 12"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544119.1">
        <property type="nucleotide sequence ID" value="XM_009545824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGK8"/>
    <dbReference type="FunCoup" id="W4KGK8">
        <property type="interactions" value="553"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KGK8"/>
    <dbReference type="GeneID" id="20672102"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_381980"/>
    <dbReference type="eggNOG" id="KOG2872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040933_0_0_1"/>
    <dbReference type="InParanoid" id="W4KGK8"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000001">
        <property type="entry name" value="Uroporphyrinogen decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091">
        <property type="entry name" value="METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091:SF169">
        <property type="entry name" value="UROPORPHYRINOGEN DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="11 12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="14">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="15">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETW84445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="369" mass="40840" checksum="99C637976DB89302" modified="2014-03-19" version="1">MSTTDFPPLKNDLLLRAARGEETERAPVWVMRQAGRYLPEFRAVRAQHEFFEICRTPDLATEITLQPIRRYAGLLDAAIIFSDILVIPQAMGMEVLMNPGPHFPDPLNTPADVVKLRENVDVNKELGYVFTAITQTRKALEGHVPLIGFSGAPWTLFAYMIEGGGSKTFQKAKTWLFKYPEESKALLMRIAEVCVDYLFGQVKAGAQLLQIFDSWAGELSPHDFAIFSLPSLKYISTSLRSRLTAANVAAVPITLFAKGANLSLAECATAGYDVLGIDWCVEPSHARRAVQATPIALQGNLDPNVLYAGRAAIEREVKRMCKEFKGEGINTPKAWIANLGHGITPGVDPDDLKWFFECVHKYSAKDAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHA4</accession>
    <name>W4KHA4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_470261</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542111.1">
        <property type="nucleotide sequence ID" value="XM_009543816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHA4"/>
    <dbReference type="GeneID" id="20677340"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_470261"/>
    <dbReference type="HOGENOM" id="CLU_074158_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHA4"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW85238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="288" mass="31205" checksum="596C84868F8B50CB" modified="2014-03-19" version="1">MARDIVEAPRDTVLRVLAEVPPQVLVEEAPELVPELPPSPETASEPVLLEHHVHVEEEPRRKKAKNGEGRDGREEGGSQGASGATAGRRIVKRPRMPPIAGYGRFSVKLPSDYAERERETAGERGQMLVVHPQAHGSAPPETTLTSTTSTYRVENPTSEPVPEAVLQFIGGPWTSTPGEEQRGARKRKRADPHVCDGTDGCSKRLSCPYDMPRHKATLRHGGQREFACGDCPALFVRKDEVHRHKREHCPNRGRKHNGRGGPSQGPRHDGPEGGGGGMGGIGDSLLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHK7</accession>
    <name>W4KHK7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_310142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542077.1">
        <property type="nucleotide sequence ID" value="XM_009543782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHK7"/>
    <dbReference type="GeneID" id="20669753"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_310142"/>
    <dbReference type="HOGENOM" id="CLU_199928_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHK7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="75" mass="8500" checksum="A0EB7035C50DBB48" modified="2014-03-19" version="1">MRRESFDTPLHALKIHAQASGSIRARSITVQVAKEFDSCYVWEDQNSSMLQQVSTYTAPIFFSAMTMDTIEASCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHN0</accession>
    <name>W4KHN0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_444349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544434.1">
        <property type="nucleotide sequence ID" value="XM_009546139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHN0"/>
    <dbReference type="GeneID" id="20675575"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_444349"/>
    <dbReference type="HOGENOM" id="CLU_352342_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHN0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="865" mass="94378" checksum="BC380418BC02FFD4" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJ19</accession>
    <name>W4KJ19_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate esterase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_115074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542659.1">
        <property type="nucleotide sequence ID" value="XM_009544364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJ19"/>
    <dbReference type="STRING" id="747525.W4KJ19"/>
    <dbReference type="GeneID" id="20666461"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_115074"/>
    <dbReference type="eggNOG" id="ENOG502S0SQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015101_4_2_1"/>
    <dbReference type="InParanoid" id="W4KJ19"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01846">
        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF85">
        <property type="entry name" value="A, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844276" evidence="2">
        <location>
            <begin position="23"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW85843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="308" mass="33416" checksum="38E1867018F45861" modified="2014-03-19" version="1">MFSRAQTTLVASVLLGVSSVSALTWGSTKFLFVFGDSYTTTGWNISAGINSPVPGFTSSNGQNWVQYLGGTYNVTDTQVFNLAFGGATIDSALVAPYSPTVQSIVTQVSLFEQFLGSKPAGAPWKSDNSLFALWIGINDVGNSFAWNNVSQSAFHTTLMTRLFGQVEELYQSGARSFLFLTVPPTNRAPLLVVQGPTVTARITSSIADYNNQLRSFATKFRQQHKDLDQIVVFDTQPIFNTLLNNAGTFGYVNITGFCEAYQNGTSDVSTQIAPCAPVSDYFWLNTLHPLFTVHDVIAKAISTVLSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4KK30</accession>
    <name>W4KK30_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_154262</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542841.1">
        <property type="nucleotide sequence ID" value="XM_009544546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KK30"/>
    <dbReference type="FunCoup" id="W4KK30">
        <property type="interactions" value="391"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KK30"/>
    <dbReference type="GeneID" id="20667483"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_154262"/>
    <dbReference type="eggNOG" id="KOG1165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019279_2_7_1"/>
    <dbReference type="InParanoid" id="W4KK30"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14127">
        <property type="entry name" value="STKc_CK1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000160">
        <property type="entry name" value="Casein kinase I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW86059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="306" mass="35150" checksum="09E4E798655C9794" modified="2014-03-19" version="1">MSSHTHNSSTTNIVGIHYRVGKKIGEGSFGVIFEGTNLLNSQSVAIKFEPRKAEAPQLRDECRSYRILSGCTGIPQIYHFGQEGLHNILVIDLLGPSLEDLFDMCGRKFTIKTVCMAARQMLSRVQTIHEKNLIYRDIKPDNFLIGRPGTKNSNVVHVVDFGMAKQYRDPKTKQHIPYRERKSLSGTARYMSINTHLGREQSRRDDLESLGHVFMYFLRGSLPWQGLKAATNKQKYEKIGEKKQTTPIKELCDGFPEEFGIYLNYVRKLGFEETPDYEFLRELFAKVMKNNNDIDDGVYDWNLLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4KK45</accession>
    <name>W4KK45_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoside phosphatase GDA1/CD39</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_60065</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541824.1">
        <property type="nucleotide sequence ID" value="XM_009543529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KK45"/>
    <dbReference type="FunCoup" id="W4KK45">
        <property type="interactions" value="189"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KK45"/>
    <dbReference type="GeneID" id="20678493"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_60065"/>
    <dbReference type="eggNOG" id="KOG1386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010246_3_1_1"/>
    <dbReference type="InParanoid" id="W4KK45"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046036">
        <property type="term" value="P:CTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006256">
        <property type="term" value="P:UDP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24039">
        <property type="entry name" value="ASKHA_NBD_YND1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF121">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATASE MIG-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="196"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW86217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="53868" checksum="EBF692724232317D" modified="2014-03-19" version="1" fragment="single">MPPPTAADAWLNSRRFGIVIDAGSSGSRLQIYSWRDARAVRDELGAKVYHSLPKVEKGTQSGEDWVTKVEPGISSFSDNPEGVSAYLAPLLAHARERIPPSLHAQTPLFLLATAGMRLLSPEQQATVLQSTCHFLKFHSNFRIDEPSPAGPCGSSIRIITGEEEGLFGWIAVNYLMDGFGPSDADRTTYGFLDMGGASTQIAFEPSREEREKAKNLIDVRLRLMGGEEIHHQVFVTTWLGYGTNMARERYVGRAINEYEQHQPSPLSVSSSDSSEIIEDPCLPKDLRLTESPAHTSPSTSHTRKPHTFLGTGSFGQCLQRVSPLLNRSAPCPDTPCLFNGVYVPPIDFSVSHFIGVSEYWYSSEHIFGLGGAYDFVQYERAALDFCGKNWSDILQMHEQARQRGRLGGDGEMQCFKAAWIVNVLHEGLGMPRIVDPGGNVTSHPDALETHAQEKGLGRPTFQSIDSVGDIAISWTLGKIVLEASKDIPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKJ6</accession>
    <name>W4KKJ6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_311198</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BUB2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543085.1">
        <property type="nucleotide sequence ID" value="XM_009544790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKJ6"/>
    <dbReference type="FunCoup" id="W4KKJ6">
        <property type="interactions" value="67"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KKJ6"/>
    <dbReference type="GeneID" id="20669847"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_311198"/>
    <dbReference type="eggNOG" id="KOG2058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029367_2_0_1"/>
    <dbReference type="InParanoid" id="W4KKJ6"/>
    <dbReference type="OrthoDB" id="10263206at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990334">
        <property type="term" value="C:Bfa1-Bub2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010948">
        <property type="term" value="P:negative regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000035">
        <property type="entry name" value="Cell cycle arrest protein BUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000026">
        <property type="entry name" value="Mitotic check point protein (Bub2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF263">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="7">
        <location>
            <begin position="54"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW86337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="313" mass="35927" checksum="35D06D3876E89CAB" modified="2014-03-19" version="1">MSEQERSSPESIAHSFSKILAPSKTSSKSRSQQDVEEGVRKLRRLILIDGIPSQVDSTLRPRIWKILLRVNELPASTFLEYVARGPCAVREKIRNDTFRTLATDRGFKERVREDMLVRLLDAFVWRNHDRQETHHLDFTYVQGMNVLAAPFLYTMPSELEAFFCFANFIEECCPLYVQPTLEGVHRGLKLLDRCLRIVDPELFAYLRSKNLSAELYAFPSVLTLCACTPPLDQVLKLWDFLLAFGVHLNVLCVIAQLLLIRDEVMNSSSPMRILRTFPPIEALPVIGIAVTLVRDLPPELYDELVRHPYDINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KL87</accession>
    <name>W4KL87_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_447223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540489.1">
        <property type="nucleotide sequence ID" value="XM_009542194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KL87"/>
    <dbReference type="GeneID" id="20675744"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_447223"/>
    <dbReference type="HOGENOM" id="CLU_050560_0_0_1"/>
    <dbReference type="InParanoid" id="W4KL87"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="344" mass="38884" checksum="9B1D5367C0F8769E" modified="2014-03-19" version="1">MLLHEDHEASSPSRNSSPDVVLMVSNPDIGRVDRGTSPHPSNAGRVDRGTSPHRPEPAVVTLTPHLNNFSDDNAEDYAKGPHEMHHGMKTLMTETYRALTKYQWEFHLLLQSRRALELQVPRDYEQEQQLNSQAMEKLSRYQLYRELHLRQYQLVDRFPTPWEELPLRSTISAGNPGMSIATYLNDWLVPVSRSEDSPSKQTLTPPLGMNITTDDHEPSSSIPTNSPSMSTESSFQLSSSPENWAPSNQVEPTLSALSSGMYHVPENVPRLYQIQEGLRTRSWNALHRGHGKVAQHIAIPRHPPLTGYEIFPYPMGVPTRRNHPSIEETREEGVEGPRQPSATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLS6</accession>
    <name>W4KLS6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aprataxin C2HE/C2H2/C2HC zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_309237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542803.1">
        <property type="nucleotide sequence ID" value="XM_009544508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLS6"/>
    <dbReference type="FunCoup" id="W4KLS6">
        <property type="interactions" value="423"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KLS6"/>
    <dbReference type="GeneID" id="20669658"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_309237"/>
    <dbReference type="eggNOG" id="KOG0562">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066882_1_1_1"/>
    <dbReference type="InParanoid" id="W4KLS6"/>
    <dbReference type="OrthoDB" id="3512845at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033699">
        <property type="term" value="F:DNA 5'-adenosine monophosphate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990165">
        <property type="term" value="F:single-strand break-containing DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000012">
        <property type="term" value="P:single strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032566">
        <property type="entry name" value="Znf-C2HE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF4">
        <property type="entry name" value="APRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16278">
        <property type="entry name" value="zf-C2HE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aprataxin C2HE/C2H2/C2HC zinc finger" evidence="2">
        <location>
            <begin position="149"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW86016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="303" mass="33873" checksum="9FB8196920F09223" modified="2014-03-19" version="1">MSHLAALRTYAVRAEPAKLPPSVYFSHTQATLTVFDTFPKSLFHFLVLPRPSPAPSGPSVLDLASLRSLLRTDPASARATLLALRQEALRLRDHIEAEMLARYGFRWDTWIGFHAAPSMEHLHLHVISADLCGPALKTKKHYNSFHPTAGFFLPLDHVLSLFDATPSYYDSFSKFNKAQYEPRLKQDLLCFHCGAPQKNIPALKAHLLHEWEQLRARTKWHLDHHAQQQQKRSLQLATATATATADAAIATATTPSAASAVPSAQKRKRQVGPDDDDGGELDDRQPKRCHLDRQPSQNAMDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLV1</accession>
    <name>W4KLV1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_122081</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543088.1">
        <property type="nucleotide sequence ID" value="XM_009544793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLV1"/>
    <dbReference type="FunCoup" id="W4KLV1">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KLV1"/>
    <dbReference type="GeneID" id="20666768"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_122081"/>
    <dbReference type="eggNOG" id="KOG3369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053380_2_2_1"/>
    <dbReference type="InParanoid" id="W4KLV1"/>
    <dbReference type="OrthoDB" id="246406at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14856">
        <property type="entry name" value="TRAPPC4_synbindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000007">
        <property type="entry name" value="Putative sybindin-like family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF15">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW86340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="136" mass="14546" checksum="A184C9F3CC1C2C98" modified="2014-03-19" version="1">MAIFGLWVINKAGGLVYQRNFAEGLAQLTSNEYLVLAGTLHGIHAITSRLSPSGPSSGAHVIEGESFKMTISLTLTGTKFVLLTSLAEHSADAVLQKVYEAYADAVMKNPFHTPEMPIRTEGFDARISAIIGTGHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4KM42</accession>
    <name>W4KM42_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Brix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_308509</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BRX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542903.1">
        <property type="nucleotide sequence ID" value="XM_009544608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KM42"/>
    <dbReference type="FunCoup" id="W4KM42">
        <property type="interactions" value="613"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KM42"/>
    <dbReference type="GeneID" id="20669594"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_308509"/>
    <dbReference type="eggNOG" id="KOG2971">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048373_2_1_1"/>
    <dbReference type="InParanoid" id="W4KM42"/>
    <dbReference type="OrthoDB" id="1638493at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000009">
        <property type="entry name" value="Ribosome biogenesis protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026532">
        <property type="entry name" value="BRX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRX1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="48"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="267"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW86131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="305" mass="34807" checksum="DC44BA2D5BC73340" modified="2014-03-19" version="1">MASVLKAQKANASLIDSKGKGKRKADAMDVDEEAVESSVPMKKKKNKQRVLMLSSRGVTHRMRHLMNDLEVLLPHIKKDSKLDSKNHLNLLPELADLHNCNNTLYFEARRHEDLYLWAAKTPNGPSVKLHVQNVHTMDELKLTGNCLKGSRGLLSFDASFEETEWGRLMKELFTHMFGVPPQARRAKPFIDHILTFSLLDGKIWFRNFQIIEKDPLHPSGPPQTTLIEIGPRFVMTPIRIFEGAFNGATVFSNPEYISPTSVRSAIRREKGTKYKERKHAQSERSDRKDLRKLPENELAVSKVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KM90</accession>
    <name>W4KM90_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_377405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540788.1">
        <property type="nucleotide sequence ID" value="XM_009542493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KM90"/>
    <dbReference type="GeneID" id="20671876"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_377405"/>
    <dbReference type="HOGENOM" id="CLU_568117_0_0_1"/>
    <dbReference type="InParanoid" id="W4KM90"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="481" mass="49525" checksum="B3BE63833BB5A176" modified="2014-03-19" version="1" fragment="single">MTGQSSCAEDRFTYDFPMPRAPTSPPPPRVGTGAYTHNVALAASVRRPPFVRASAPAATAQALPRTGRGRSLVLGLAGGDADGDGDEGADDSVVPFKQVLSATRGALFADESPATVPSHSSSSSSSSPSSSSSASLASRSQRPRNSTLPRSRASSPENPPEAANATDAADALSPSPARRRPELLRTLLAEVHWARDERRHTRAGGHTRTASASSAAKRPPPSSERRAVHPQLLIGACKACAVTGVPDPFLELAAAAGAGSTGSAGSSAGASSSSSSTLASWFSFGTRKSASTAASSVRSAKQQQPARRDSHAGAGPAQGEEEREETPLRHSCRRGQCFVAVELWESPLAPAGEGPPVPAPRVPALGDEGARARTRRASGVGIGRRLSVSLGTVLRAVGRAHGAYVRAAMLSAGVDARARDDADENGGEDGWACMAARRDGYRVRRADVGVFLGVGPGGGGKPKAELARGRRPYTLHPLMPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNL2</accession>
    <name>W4KNL2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_307816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540938.1">
        <property type="nucleotide sequence ID" value="XM_009542643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNL2"/>
    <dbReference type="STRING" id="747525.W4KNL2"/>
    <dbReference type="GeneID" id="20669530"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_307816"/>
    <dbReference type="eggNOG" id="KOG2362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028286_1_0_1"/>
    <dbReference type="InParanoid" id="W4KNL2"/>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF19">
        <property type="entry name" value="MITOCHONDRIAL AMIDOXIME REDUCING COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="213"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="382" mass="42278" checksum="1961D6B0BA92A7F0" modified="2014-03-19" version="1">MLACRLLLSIIFEPARLKNASESLSRLHSSSSEALETSFIFDATKNQDAVQKRLDAGKVTVSRIMVYPIKSCRGISVLKSNFTPLGLEYDRQWCIIDAMSHRIITARAVPKMVLITPRVIESDIDPCGGRLQISFPAESGCETFFVPLKPTSDMLQNYSITDDCSVHSDTGIDGYITQPHPDSSNTDALLCSATLSKYFGKPVHLIFKGSRARPVEPTWSFPNLNAHLNYQDGYPLMVVSEESFGSVKKMAAKWCSEQDIDEFKHWNVDSLVLERYRPNIVFNGASVPFSEDMWREIVLTSHTNESSSFTLVAKCTRCLLPNIDPLNGVRNMSIPSKPLSKFRTGLDPGRTDDSCFGCNAVGLASGVMSVGDVVSVTTWDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNN8</accession>
    <name>W4KNN8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LYR motif-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_306094</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in efficient integration of the N-module into mitochondrial respiratory chain complex I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541329.1">
        <property type="nucleotide sequence ID" value="XM_009543034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNN8"/>
    <dbReference type="STRING" id="747525.W4KNN8"/>
    <dbReference type="GeneID" id="20669377"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_306094"/>
    <dbReference type="HOGENOM" id="CLU_151409_2_2_1"/>
    <dbReference type="InParanoid" id="W4KNN8"/>
    <dbReference type="OrthoDB" id="74240at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd20262">
        <property type="entry name" value="Complex1_LYR_LYRM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045293">
        <property type="entry name" value="Complex1_LYR_LYRM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675:SF0">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="7">
        <location>
            <begin position="13"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW87427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="77" mass="9068" checksum="9253230A8279C8F4" modified="2014-03-19" version="1">MHQPTLKHFILKQQALDLFRSAIRASRSIPDVVAREETIVWIRAEFERKRHLQDVAAIEDALKAGRRDMKHYFPASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPN6</accession>
    <name>W4KPN6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_423990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540968.1">
        <property type="nucleotide sequence ID" value="XM_009542673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPN6"/>
    <dbReference type="GeneID" id="20673948"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_423990"/>
    <dbReference type="HOGENOM" id="CLU_669134_0_0_1"/>
    <dbReference type="InParanoid" id="W4KPN6"/>
    <dbReference type="OrthoDB" id="2744793at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="411" mass="46114" checksum="D975748162926518" modified="2014-03-19" version="1">MSRQKGSMEKMNIAMLAITLFMFAVSTTVWALSLASIVEMVKIIHLSDPTRSPEDISHALVQSSNALYGKAELVFIINFILSDCVVAWRACVLWQGSKRKMIILFCFLSGCGIGCISNTIKDNGFCNDTQYIGLGISLSINMLATILVGNTAWRHRRFIMNTLGHSSRRTQVEKILVLLIESSVLYCFACVMLIVCSFIRLPSGFVGIYPTVLLLLVAFKRTIWDFPGNASQVGPSDIHYASGSVTGVQQRRTSDRDLSSSECVRADELKPFWSAARDQRRDYEHAIVLSHRVQFLSMMPGVTWGMEHSVIIFEFRCNTEFLIAFKIRGLTKAEESLIHDCPVATVKSALFKVEYPKRKATDGAGTMSGTRQSMPRLNVLNVEHRMPFVSVQMSTRCTTQPKRDPLLYPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPQ2</accession>
    <name>W4KPQ2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dynein heavy chain, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HETIRDRAFT_457162</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541568.1">
        <property type="nucleotide sequence ID" value="XM_009543273.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="W4KPQ2">
        <property type="interactions" value="403"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KPQ2"/>
    <dbReference type="GeneID" id="20676798"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_457162"/>
    <dbReference type="eggNOG" id="KOG3595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000038_7_0_1"/>
    <dbReference type="InParanoid" id="W4KPQ2"/>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000122">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000005">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000071">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000517">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000007">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000003">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000004">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000004">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000373">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000013">
        <property type="entry name" value="Dynein heavy chain-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="732"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="1408"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="1750"/>
            <end position="1916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="3168"/>
            <end position="3189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="2026"/>
            <end position="2074"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="2231"/>
            <end position="2279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="3174"/>
            <end position="3188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETW87699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="3450" mass="391682" checksum="E5A0A8C78F22D45F" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W4KQT6</accession>
    <name>W4KQT6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TFIID subunit TAF5 NTD2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_59490</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat TAF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540412.1">
        <property type="nucleotide sequence ID" value="XM_009542117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KQT6"/>
    <dbReference type="FunCoup" id="W4KQT6">
        <property type="interactions" value="279"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KQT6"/>
    <dbReference type="GeneID" id="20678478"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_59490"/>
    <dbReference type="eggNOG" id="KOG0263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005884_2_1_1"/>
    <dbReference type="InParanoid" id="W4KQT6"/>
    <dbReference type="OrthoDB" id="10266330at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08044">
        <property type="entry name" value="TAF5_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.500">
        <property type="entry name" value="TFIID subunit TAF5, NTD2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007582">
        <property type="entry name" value="TFIID_NTD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF1">
        <property type="entry name" value="CANNONBALL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04494">
        <property type="entry name" value="TFIID_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="Taf5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="TFIID subunit TAF5 NTD2" evidence="10">
        <location>
            <begin position="135"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="505"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="553"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="595"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="637"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="679"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="306"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="718"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="730"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW87411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="786" mass="85517" checksum="BBD645E9294B031E" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4KR53</accession>
    <name>W4KR53_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_42421</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540363.1">
        <property type="nucleotide sequence ID" value="XM_009542068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KR53"/>
    <dbReference type="GeneID" id="20673953"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_42421"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="InParanoid" id="W4KR53"/>
    <dbReference type="OrthoDB" id="2351791at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW87556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="557" mass="59786" checksum="A99CC12992F08432" modified="2014-03-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
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            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
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            <position position="58"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW87586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="58" mass="6901" checksum="D9166BFCF2814155" modified="2014-03-19" version="1" fragment="single">EEKRRRNTAASARFRIKKKQKTLNLERTVSDLTGRVDELEQEASDLRRENGWLKEIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
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    <name>W4JMC3_HETIT</name>
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        </recommendedName>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GeneID" id="20675728"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_447059"/>
    <dbReference type="eggNOG" id="KOG1208">
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    </dbReference>
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    <dbReference type="InParanoid" id="W4JMC3"/>
    <dbReference type="OrthoDB" id="191979at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
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    </dbReference>
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    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
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        <location>
            <begin position="389"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="485"/>
        </location>
    </feature>
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        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="51938" checksum="9641F686AD9BF55A" modified="2014-03-19" version="1">MVLKIAHATLTSILPSKYYTHAVLVIVAIITIHAYAQGRKTNRERDLHGRSIIVTGAFTPIGLTLLDSLARRGAHLIALSPDPVDLSEGAPATSAALLVPVLRSTTNNENIYAEHCDLTSPASIRAFCAHFVQGEQQRLDAILFAHEYAHIGPMLPTKPTRDVVKERRDASCATFLLTTLLLPVLLVAPVERDIRLVTLINPFYAAAAATFSALPTPGTASTSTYPQSALFLTEGRRALRTAIMTRHLQRVLDALPASAQVPRANSDASTVPVVSDKVQRSNIVTVSVSPGVSRSDIIAPLLGADTPRQGVSISGIILYFLATPILRMLTKSSASAAQGVLHTLFLPTPFKRLATSSTPGATAQFLDPEEVLKPGALYAECAVTRLHVPLPPAPPENDSESDASSQTSNAAGASDNPGTMRQTVDDGELGGEVLGTLVWDEYERELKAWEALEIEEQRRAKQGDQKRGGLEDGRHTPPTVDETSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMI4</accession>
    <name>W4JMI4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_482551</name>
    </gene>
    <organism evidence="12 13">
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        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
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            <taxon>Agaricomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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</entry>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
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                <person name="Cullen D."/>
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                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Hansson D."/>
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                <person name="Lin Y.C."/>
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                <person name="Lucas S."/>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="209"/>
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    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="209" mass="22441" checksum="CE4CCCD4139B8FCC" modified="2014-03-19" version="1">MSVSLTFDSPPPALVLPLPARPCLSCAPAHTRKRLLTPRLFPCSLLGGEGTTTLPGNLPPDAFFSKHAHSTLRTAAHASHERTPSSASGYMHHHAAGADESTTSPAKQRYVADAHGLEIIKKIRQGEVELRDRTIVLCDIKANVRPARFAKLRAIKDAKKPGKAPTAIPAVSGLKRLRGRHRGGAGERGGGERGRRRGRGQRRGREGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNJ4</accession>
    <name>W4JNJ4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_157644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552565.1">
        <property type="nucleotide sequence ID" value="XM_009554270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNJ4"/>
    <dbReference type="GeneID" id="20667740"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_157644"/>
    <dbReference type="HOGENOM" id="CLU_1740747_0_0_1"/>
    <dbReference type="InParanoid" id="W4JNJ4"/>
    <dbReference type="OrthoDB" id="2795185at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004843713" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="16276" checksum="2E76BCCAD351C4DA" modified="2014-03-19" version="1">MYVFSSLLPISLLAALVRAGLPELHELGRRDNVCALDLRGATAKDCLVDNKGIFFTLTPPSTITTTTVSTLPANSQCDHIVELRLLDGALQKSGVCEMITKTIKAKSSVSKAILLQPLSDVINGHDNLNFLASAVNNRVRLHDCDTRTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNW5</accession>
    <name>W4JNW5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_442452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552623.1">
        <property type="nucleotide sequence ID" value="XM_009554328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNW5"/>
    <dbReference type="GeneID" id="20675450"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_442452"/>
    <dbReference type="eggNOG" id="ENOG502SJRZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044614_3_3_1"/>
    <dbReference type="InParanoid" id="W4JNW5"/>
    <dbReference type="OrthoDB" id="3354175at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW75179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="326" mass="36307" checksum="0A91C4B860026515" modified="2014-03-19" version="1">MTTYNGVPLDRAGIVSTVMEGLLYGFSLFMFGITLWVLFYHRATKDVNRPMVVVAVLLFAFSTMHLGVDIHRIMQGLVDNRNFPNGPAAWFADPSQFTFVFKNAIYSFQTVLGDGVVIYRCYMVWQSVYIIIFPLIMLSGVAVTAAGSVWACSQATPTQGGIFFQRTGQWITAFYSSTLSTNLICTFLLAFRIWQINSRVRNHHGGSTLMPVLLIIIDAGLLYSVTLLSALLCFVNHSNGQYVVLDMVMPIISIVFYMVIIRVGIAKVTPSHQGDSSGFGNALSQTQNRDYAMRPLEVHISQLTESQKDKIDQRSDASISKHAEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4JP44</accession>
    <name>W4JP44_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_108085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552758.1">
        <property type="nucleotide sequence ID" value="XM_009554463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JP44"/>
    <dbReference type="GeneID" id="20666312"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_108085"/>
    <dbReference type="eggNOG" id="ENOG502SRD0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021768_3_2_1"/>
    <dbReference type="InParanoid" id="W4JP44"/>
    <dbReference type="OrthoDB" id="5598852at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="159" mass="18444" checksum="17B1BD6127AE1E6D" modified="2014-03-19" version="1">MTTGAWYICVERAPCVSLDKVVDDMTEEQLQHVAAQLKSILRQMHTVKPKTLGAHAFTSVGEFTDYFRRMLLYFSAEDWTEQLLSHFPRNAPIRFTHRDLIPRNIIVDGSTITAVVDWATGGFYPEYWEYCRMYNSDWLTPGWTCILQIIYLALGGTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPB7</accession>
    <name>W4JPB7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_120624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
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                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
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                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_120624"/>
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        <location>
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            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="526"/>
        </location>
    </feature>
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            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
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                <person name="Raffaello T."/>
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                <person name="Yakovlev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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        </location>
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            <position position="1"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="353" mass="37018" checksum="881C878DB1EE29CE" modified="2014-03-19" version="1" fragment="single">LGMAPDHQKAILVSETGWVVLGQAEVPKLAPGKILVKIIAAAQNPADWKGVTLGRKTGAVVGCDFAGTVEEIGPGVPPGIRTVGERVAGFVRTATSSNGAFAEYVAAPAEVVVHVPDEWSFEDAAQLGIAPFTAAQTLFITLNLPTPLSPTAESTPILISGGSSSVGLYAIQLAKLSGLRVIATASPRNFDLLKSYGADEVYDYRDPDAARKIKESTRGQLKEALDCIGEDSTPTLISNALSDSGGVVAIITKYDSPRAGVKLIRSVVFSLLGEAFDLPFTFTPTAKDIEQGRNMTKLLSETLASGKIKPNPVLVLPDGLASVPEGLQYMKDGKAVSAQKITYRISDTPTGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPR5</accession>
    <name>W4JPR5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Durling M."/>
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                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009554579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPR5"/>
    <dbReference type="GeneID" id="20671661"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_331489"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="202672at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW75459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="77" mass="9191" checksum="547DA001EA63CBFD" modified="2014-03-19" version="1">MAPYKPPRSKLGALLWRKRIWFETTFGASVLEPWEKTLFYTVLALVSTLFWAWVYKYLPHQLMSMALRARYYVSGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPY2</accession>
    <name>W4JPY2_HETIT</name>
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            <fullName evidence="5">Ribose-5-phosphate isomerase</fullName>
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        <alternativeName>
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        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoriboisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_56477</name>
    </gene>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552500.1">
        <property type="nucleotide sequence ID" value="XM_009554205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPY2"/>
    <dbReference type="FunCoup" id="W4JPY2">
        <property type="interactions" value="574"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JPY2"/>
    <dbReference type="GeneID" id="20678362"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_56477"/>
    <dbReference type="eggNOG" id="KOG3075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056590_0_1_1"/>
    <dbReference type="InParanoid" id="W4JPY2"/>
    <dbReference type="OrthoDB" id="1555531at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006014">
        <property type="term" value="P:D-ribose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000014">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000053">
        <property type="entry name" value="Ribose-5-phosphate isomerase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001924">
        <property type="entry name" value="PRK00702.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934:SF0">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW75529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="260" mass="28291" checksum="BB0BBA0014925AC1" modified="2014-03-19" version="1">MLSVNQKLSVIESSKRLAAWTAVDKHILPEHKVIGIGSGSTVPYVVERIVAQGHELNKDRVFIPTGFQSKQLIVQSHLRLGDVDEYPTIDVTIDGADEVDKDLNCIKGGGACHLREKVLAEAARTFIVVADYRKNSDVLGTTYTPGVPIEVAPFAYAKLLQNLHHLGAPQAALRMAKAKAGPVVSDNGNFIIDAPFPRQMLADPYSILAKIKMLTGVVEVGLFCHMVKAAYFGNQDGSVTVKWDDGRAEHVEKTQTPVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQ06</accession>
    <name>W4JQ06_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_442605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552954.1">
        <property type="nucleotide sequence ID" value="XM_009554659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQ06"/>
    <dbReference type="GeneID" id="20675465"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_442605"/>
    <dbReference type="HOGENOM" id="CLU_1294565_0_0_1"/>
    <dbReference type="InParanoid" id="W4JQ06"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004843818" evidence="2">
        <location>
            <begin position="24"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW75554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="210" mass="20836" checksum="355277BEBE4C207A" modified="2014-03-19" version="1">MFSFTKITSFAVLALGTFASVSALPTVKDVAPAVVAAPVVVPKTVIQERDGNTVATIFASLNVQLEPVLSGLSGAKDAATVQSGVTEVTSLIQSATTSLSGLVGQPQAQVLVKLDGSGLLSVGDVAGLVGGLLNTVFGVLGPLTTGSGAVGTLGLLTPLLSVVETLLSVVVTLLGTTVSSLLSSLLPLILGLVPQILSLVLSLLLGLLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQ28</accession>
    <name>W4JQ28_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_109330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551906.1">
        <property type="nucleotide sequence ID" value="XM_009553611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQ28"/>
    <dbReference type="GeneID" id="20666433"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_109330"/>
    <dbReference type="HOGENOM" id="CLU_1660997_0_0_1"/>
    <dbReference type="InParanoid" id="W4JQ28"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="159" mass="17333" checksum="B7DFEAE3EFE7C5F8" modified="2014-03-19" version="1">MGIDDENVVMDAPFLSRTNVMKRRSAVDAASGRLFSPRNPATQRPRAHPLDGSHPPLPRAASPPKPRARSPLCTLAPRILVLVLSAVDVPAVEVTISNGVDANPFDITAPASAREHDVLVEFLTLLAVCYTVIPELQDGKMQRRRTMMNTSNGSDREWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQ39</accession>
    <name>W4JQ39_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_57243</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553059.1">
        <property type="nucleotide sequence ID" value="XM_009554764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQ39"/>
    <dbReference type="GeneID" id="20678387"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_57243"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008523_12_3_1"/>
    <dbReference type="InParanoid" id="W4JQ39"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW74996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="488" mass="54058" checksum="B54EA7F6C81249DE" modified="2014-03-19" version="1">MHRRFQQRHSVPESHSDSSALKRRDGSTITFANPAADKFFVDGTAIPDVPFDAGPSWAGLMPISGKAGETRKLFFWFWPTTNASNANDLLFWTNGGPGCSSLEGFLQENGPISWSWGQSQPTLNPWSWTNLSNVVWVEQPVGTGFSQGTPDISNDDELAAEVLGFLEQFLEVFRELKGSNFFVSGESYAGFYVPYIANWIYEHPGGLDLHLKGIWIADPSLSYNVVQQEIPALRFAQANANVFPFNSSFMAQLQNISDTCGYTDYLDQFLTYPPAGQLPLPVGTNGTFNAIPSCRIHRLVQSAVTTLNPAFDVYRVTEAWPIPWSVLGFPRSTQEFVYFNRTDVQNAIHAPHVVWEACQGPVYINATTGAPGNDQSIPSTLSVLPNVIEKSERTVIIHGLADFILVSEGTRIAIQNMTWGGAQGFQTPIEAESFVVQDFGVYGNMHQERKLTYVEFYYSGHMTPQFVPWAAFQTIAYLLGKADSPSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQG1</accession>
    <name>W4JQG1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_430263</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551985.1">
        <property type="nucleotide sequence ID" value="XM_009553690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQG1"/>
    <dbReference type="STRING" id="747525.W4JQG1"/>
    <dbReference type="GeneID" id="20674433"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_430263"/>
    <dbReference type="eggNOG" id="KOG1318">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010505_0_0_1"/>
    <dbReference type="InParanoid" id="W4JQG1"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11387">
        <property type="entry name" value="bHLHzip_USF_MITF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776">
        <property type="entry name" value="MIP04163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776:SF2">
        <property type="entry name" value="MIP04163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="735"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="224"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="287"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="333"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="461"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="638"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="726"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="794"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="877"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="919"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="370"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="471"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="585"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="739"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="794"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="919"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="953"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="973"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="983"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1039"/>
            <end position="1061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW75724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1061" mass="109410" checksum="EF0AA45B39512696" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQK1</accession>
    <name>W4JQK1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_156920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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                <person name="Asiegbu F."/>
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                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
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                <person name="Durling M."/>
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                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
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        <location>
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    </feature>
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    </evidence>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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</entry>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="94" mass="10682" checksum="DA32F4D20D964760" modified="2014-03-19" version="1" fragment="single">PTAVAMIVTGLWMWVDAGIKRLQPYVDLVHGGSPAKRSLLLDYTHIQCSYGHRRYLVWYTANRNKHYAIFISSLVLIVTATFQFLASSLLIVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQZ4</accession>
    <name>W4JQZ4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_422526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552124.1">
        <property type="nucleotide sequence ID" value="XM_009553829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQZ4"/>
    <dbReference type="GeneID" id="20673819"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_422526"/>
    <dbReference type="HOGENOM" id="CLU_3143266_0_0_1"/>
    <dbReference type="InParanoid" id="W4JQZ4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW75884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="49" mass="5758" checksum="3D05C2EDEE1CB410" modified="2014-03-19" version="1">MLNSVDLIPEILRFLKGELYLCKPNVMPWMSWSMQGKILMVHGFFCNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4JR47</accession>
    <name>W4JR47_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_482075</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552770.1">
        <property type="nucleotide sequence ID" value="XM_009554475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JR47"/>
    <dbReference type="FunCoup" id="W4JR47">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JR47"/>
    <dbReference type="GeneID" id="20678006"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_482075"/>
    <dbReference type="eggNOG" id="KOG3923">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034311_1_1_1"/>
    <dbReference type="InParanoid" id="W4JR47"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF11">
        <property type="entry name" value="D-ASPARTATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004843839" description="FAD dependent oxidoreductase domain-containing protein" evidence="7">
        <location>
            <begin position="18"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="8">
        <location>
            <begin position="3"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="44"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW75341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="362" mass="39645" checksum="39BA0A258366DAAF" modified="2014-03-19" version="1">MVHVVVLGAGVIGLSTAISIREKGYHVTLLAQYLPGDPKNIGYTSPWAGAHHVSSAGNNETQRKLDRETFDVMWKLSGGGDAQHCFHRVRQYEYYLDESGYEALAHMPNFRRLGPTELRPGCTSGITFSTLTINTSLYLPYLLSRLQRIGGKVHRCIIQHINQVSEGAFTDGVCPDALIVCTGLGARSLGGVEDQNVFAIRGQTVLLKAPWVDVGLSKNEPGGKWTYIMPHRNGNVVVGGSAQPHDWYPHCRPEVTRDILERANSLCPELATPLLRGTSRAPSADDLYPLIVDMGCGMRPGRQGGVRLEGSFLDIKDLPAKIPLIYNYGHAGFGYQASWGSANAVVDLLQDMLPKRVERAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4JR52</accession>
    <name>W4JR52_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_67739</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552525.1">
        <property type="nucleotide sequence ID" value="XM_009554230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JR52"/>
    <dbReference type="STRING" id="747525.W4JR52"/>
    <dbReference type="GeneID" id="20678824"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_67739"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_0_3_1"/>
    <dbReference type="InParanoid" id="W4JR52"/>
    <dbReference type="OrthoDB" id="2410195at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="5">
        <location>
            <begin position="81"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="241"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW75346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="468" mass="50797" checksum="B68364B703616296" modified="2014-03-19" version="1">MPSTLKLLSNLIAASVGDIQAACDARGVPFPSLDEVFSQETEEIRNQPEVLKAIGILVAAATQLIATARATPTFIASASMQYMVTACLGVVNDGHVAEILREAGPQGLHASDIAKRSGMNASRISKVLRLLATNHIFREITPDVFTNNRTSSLLDTNKAVDELLENSLGKHDGTPGYAAFVGHQTDECFKIASALSETLRDPVFGHSDEPTQCALTKAMHNNLPAFEFLELPENAHRLRRFGVVMDASTKLQPANAILNGFNFTSLPDNSLVIDVAGGIGSVSLVLAKAYPRLNFLVEDRPKTVFWKANFPEALTTGRVKFVAHDIFSPQPDAYKNPAVFILRSILHDWSDAYATRILKHLRSAAGPETKLVVIDHVLPYSCPSDLGTEESVKGLNTPLPPAPLLANMGGAGSLQYSLDILMLSIQNGQERTSSHFVTLLKNTGWELKEIKRTDAIGSWYPHLISTPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRK1</accession>
    <name>W4JRK1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_412335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552410.1">
        <property type="nucleotide sequence ID" value="XM_009554115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRK1"/>
    <dbReference type="GeneID" id="20673018"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_412335"/>
    <dbReference type="HOGENOM" id="CLU_2455009_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRK1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="89" mass="9793" checksum="6596BB5BDF12D335" modified="2014-03-19" version="1">METNVHAAEKDCVNDTSSVKKMAIRAYTPLDIQFYDSPLRLEQSASAQPTSTSTSESASTPRDAHPCRIYIVSHARSQPSLSTMIHRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W4JS51</accession>
    <name>W4JS51_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Alpha-amylase</fullName>
            <ecNumber evidence="4 12">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HETIRDRAFT_65781</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4 12"/>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551196.1">
        <property type="nucleotide sequence ID" value="XM_009552901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JS51"/>
    <dbReference type="STRING" id="747525.W4JS51"/>
    <dbReference type="GeneID" id="20678754"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_65781"/>
    <dbReference type="eggNOG" id="KOG2212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013336_3_1_1"/>
    <dbReference type="InParanoid" id="W4JS51"/>
    <dbReference type="OrthoDB" id="550577at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11317">
        <property type="entry name" value="AmyAc_bac_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05808">
        <property type="entry name" value="CBM20_alpha_amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000552">
        <property type="entry name" value="Related to glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031319">
        <property type="entry name" value="A-amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00632">
        <property type="entry name" value="Aamy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 12 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM20" evidence="14">
        <location>
            <begin position="445"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="519"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="531"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="545" mass="57578" checksum="FE8D3475F1A86D9D" modified="2014-03-19" version="1"> </sequence>
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                <person name="Asiegbu F."/>
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                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
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                <person name="Yakovlev I."/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">TC 32-1</strain>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Asiegbu F."/>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Henrissat B."/>
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                <person name="Karlsson M."/>
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                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">TC 32-1</strain>
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            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
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        </location>
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        </location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
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                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
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                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551822.1">
        <property type="nucleotide sequence ID" value="XM_009553527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JU29"/>
    <dbReference type="GeneID" id="20677955"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_481085"/>
    <dbReference type="HOGENOM" id="CLU_2831492_0_0_1"/>
    <dbReference type="InParanoid" id="W4JU29"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="66" mass="7410" checksum="27036A3FF96FA8DE" modified="2014-03-19" version="1">MRISADINDVYTRQNSRLFNSKQFSLQRFPCLRSVLMVLPPGSNLCSSPRASSTPDRLPRKAPSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUB7</accession>
    <name>W4JUB7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_421251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550609.1">
        <property type="nucleotide sequence ID" value="XM_009552314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUB7"/>
    <dbReference type="GeneID" id="20673714"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_421251"/>
    <dbReference type="HOGENOM" id="CLU_2469370_0_0_1"/>
    <dbReference type="InParanoid" id="W4JUB7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="88" mass="9646" checksum="B62794171946DA36" modified="2014-03-19" version="1">MRCNTTICYNLAKLTSANPSLLHPHLIHQPQTFAMILGTASSFTLILLIVATSYFYPLGMNSPLRFSDIEGMASTHELIGTHTSPVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUC3</accession>
    <name>W4JUC3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Atypical 2-cysteine peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_65882</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551201.1">
        <property type="nucleotide sequence ID" value="XM_009552906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUC3"/>
    <dbReference type="FunCoup" id="W4JUC3">
        <property type="interactions" value="215"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JUC3"/>
    <dbReference type="GeneID" id="20678759"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_65882"/>
    <dbReference type="eggNOG" id="KOG0541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072440_3_1_1"/>
    <dbReference type="InParanoid" id="W4JUC3"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF39">
        <property type="entry name" value="PEROXISOMAL MEMBRANE ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="14"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW76481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="167" mass="17537" checksum="DC5B10E0F3D415C5" modified="2014-03-19" version="1">MSITSTSLLTKAQVTPGEKIPTLTVKETNPGETITLDLKGKNIIIGVPGAFTPPCSSQVPGYIEKYDEFKAKGVNNIYVVAVNDAFVTKAWKEKLAPNGTSVRFIGDDQGLLVGSLGLLQDATGLLGNPRSKRFAIVADEGAVSSLTIEEDSSTVVSTAADKILAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUW7</accession>
    <name>W4JUW7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_118485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="169"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW77322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="336" mass="36376" checksum="26139E4289C8B88F" modified="2014-03-19" version="1">MASLRDQSEAAAVSDLVATLSPPSTAPPSYGNGFWRPEEEDVVTINGDFLTADLAGASHASLVSERLYRVQQSQHSHVTDSGLASSHRTPYLRGSSEAGAQRSMEIVLSWNPPAAARGSIGSFLTNTVQRESSSFLGVGTPTLEPSTYAFCPLSSNSMLLVPPASAGPRPHYHVSVHLDCFNPTSYSTVVRRGESEAGQYVGEFKLAGSNEPDMVTIGAETMRVSTALTVIRKKGFLSRLLCHRGGVGSFEHSWIWRFGKVHLLWRCNDDIYECALKASEDGRFLLPIMVATFVKKSTAIVGRSTHQRLAELKVYPKGLAVLDQIVVSILVIARGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUX3</accession>
    <name>W4JUX3_HETIT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_174921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009553450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUX3"/>
    <dbReference type="GeneID" id="20668539"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_174921"/>
    <dbReference type="HOGENOM" id="CLU_3068963_0_0_1"/>
    <dbReference type="InParanoid" id="W4JUX3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="53" mass="6275" checksum="237A705EB02C1A88" modified="2014-03-19" version="1">MMQKQESYRLGCLRLVEPEWETWYKIDRSCFGHICMRRISLGNLAVPKAYPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVC0</accession>
    <name>W4JVC0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_460668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551017.1">
        <property type="nucleotide sequence ID" value="XM_009552722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JVC0"/>
    <dbReference type="GeneID" id="20677096"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_460668"/>
    <dbReference type="HOGENOM" id="CLU_1250814_0_0_1"/>
    <dbReference type="InParanoid" id="W4JVC0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="221" mass="23729" checksum="2B4FBF8C1C299D17" modified="2014-03-19" version="1">MNEPFLPPRRYAYDGAGGEQEAAPSASSAPALASPTGSGAAAPPPPPNGMLYELAEIATEGHARHSGQSVLGHSQPQSQSQAQSQSHSHLHSHSHSHSHLESHSHRHLHAQPQLEPLAHAYSQQQRQQQPLAQPSHRHPHPQQQQPHLPADAYYRLDALSLPPPPPPQQQQQQQLMHADGAASAATFSSDSFGIAWNAFLESDGMPMGCGPEGMLPPEWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVS8</accession>
    <name>W4JVS8_HETIT</name>
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        <recommendedName>
            <fullName evidence="4">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_52309</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550492.1">
        <property type="nucleotide sequence ID" value="XM_009552197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JVS8"/>
    <dbReference type="STRING" id="747525.W4JVS8"/>
    <dbReference type="GeneID" id="20678208"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_52309"/>
    <dbReference type="eggNOG" id="KOG0263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0271">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_6_3_1"/>
    <dbReference type="InParanoid" id="W4JVS8"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050349">
        <property type="entry name" value="WD_LIS1/nudF_dynein_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44129">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="1"/>
        </location>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW77185.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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            <end position="235"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>W4JW57</accession>
    <name>W4JW57_HETIT</name>
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        <recommendedName>
            <fullName evidence="10">Plasma membrane ATPase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="13" type="ORF">HETIRDRAFT_38894</name>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="10"/>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009551339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JW57"/>
    <dbReference type="STRING" id="747525.W4JW57"/>
    <dbReference type="GeneID" id="20672390"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_38894"/>
    <dbReference type="eggNOG" id="KOG0205">
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    <dbReference type="HOGENOM" id="CLU_002360_6_4_1"/>
    <dbReference type="InParanoid" id="W4JW57"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase 4 plasma membrane-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000004">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="708"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="736"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="776"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="853"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="886"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="12">
        <location>
            <begin position="74"/>
            <end position="146"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW77783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1006" mass="109520" checksum="25573F803AADB80B" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWC4</accession>
    <name>W4JWC4_HETIT</name>
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        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">HETIRDRAFT_67243</name>
    </gene>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWC4"/>
    <dbReference type="GeneID" id="20678804"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_67243"/>
    <dbReference type="eggNOG" id="ENOG502SPDB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_903313_0_0_1"/>
    <dbReference type="InParanoid" id="W4JWC4"/>
    <dbReference type="OrthoDB" id="5327923at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="3"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW77858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="308" mass="34829" checksum="D421F1930EDF675D" modified="2014-03-19" version="1">MRLSAGSMLGEGHHSSVYLSALTLPRPLSARTLTGEVSVACKMSDLDPEAREHLENEAKIYASFPKHLQEDWCGLNMMPPIKTPVPACAVVPKFYGYYKPAFDEEAFRSESDEVRAEMKAFIERLSPILLMEHCGIPIVTSKNFHVDKKILCYSMLRRLHMNDYIHNSFYQRNVLVQTGPLTTPPEERSMKMPSYRVIDFGRSKLYGLSNDKAAKFDAGWGNELNRATEELNMEPFVYQEPHSCLLKVSDHFVKCIVVSAMLYHQASPCCPACYHVTVLCNRYTTLLFVSVEVDALSAFSSIEHYAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JX15</accession>
    <name>W4JX15_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_107709</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550103.1">
        <property type="nucleotide sequence ID" value="XM_009551808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JX15"/>
    <dbReference type="GeneID" id="20666270"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_107709"/>
    <dbReference type="HOGENOM" id="CLU_2967252_0_0_1"/>
    <dbReference type="InParanoid" id="W4JX15"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="59" mass="6734" checksum="707A3B06C26E7263" modified="2014-03-19" version="1" fragment="single">MTHRGLAVEIPPAYIYTYLANVVCATVPTDGVLERSDVRSPRVRDHHPRTLYRAQYSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JX95</accession>
    <name>W4JX95_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_327031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551002.1">
        <property type="nucleotide sequence ID" value="XM_009552707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JX95"/>
    <dbReference type="GeneID" id="20671287"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_327031"/>
    <dbReference type="HOGENOM" id="CLU_024199_2_2_1"/>
    <dbReference type="InParanoid" id="W4JX95"/>
    <dbReference type="OrthoDB" id="2823464at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004843938" description="F-box domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="537" mass="60924" checksum="2DE5BA89EECC2151" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXZ8</accession>
    <name>W4JXZ8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_325922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ETW78319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXZ8"/>
    <dbReference type="GeneID" id="20671189"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_325922"/>
    <dbReference type="HOGENOM" id="CLU_109019_0_0_1"/>
    <dbReference type="InParanoid" id="W4JXZ8"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="16989" checksum="D06597CC6D21E046" modified="2014-03-19" version="1" fragment="single">EASAGWGLQLASWRPAEARPIQGNTITYNNGHIGNHLPIEHPFAESIPVSIAGPDTSALPTDAQAANSYEVSLRGGETRVRRKKLHGKGPHICKLDGKVFRHHGDLVRHRKTKPGHAEYQGPVVCICLQEFSRRDGLYTHLKTKRCRSLFPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JY56</accession>
    <name>W4JY56_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_109064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550442.1">
        <property type="nucleotide sequence ID" value="XM_009552147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JY56"/>
    <dbReference type="GeneID" id="20666408"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_109064"/>
    <dbReference type="eggNOG" id="ENOG502SX1U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107676_0_0_1"/>
    <dbReference type="InParanoid" id="W4JY56"/>
    <dbReference type="OrthoDB" id="3226519at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844162" evidence="1">
        <location>
            <begin position="20"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="185" mass="19902" checksum="7DFA400D442366F1" modified="2014-03-19" version="1">MQLLSILALALSFSGAVLAVQCDDKKTLSQTVIGANKDVSVQVVHCSNTITPVADTIAVRDVPVLEKRQANVCGATCTTNCFTPSGGGPDPNECNVIADALLYDSQNIGPLFTMDPAQNSSLIVMTYRSCETFIVNQANTSLQYCRSDWSSLVDYIAFNCQSTENAHGGNCVASDQRWFVQVQHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYJ2</accession>
    <name>W4JYJ2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_142758</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548856.1">
        <property type="nucleotide sequence ID" value="XM_009550561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYJ2"/>
    <dbReference type="GeneID" id="20667020"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_142758"/>
    <dbReference type="HOGENOM" id="CLU_3068956_0_0_1"/>
    <dbReference type="InParanoid" id="W4JYJ2"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW78519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="53" mass="5498" checksum="0EC0557881A14230" modified="2014-03-19" version="1">MPSKFRVAICGGGVGGLTLASALSKCSEIDIDVYEAAPQFSEAGADIGVWRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4K194</accession>
    <name>W4K194_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_460075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549376.1">
        <property type="nucleotide sequence ID" value="XM_009551081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K194"/>
    <dbReference type="GeneID" id="20677041"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_460075"/>
    <dbReference type="HOGENOM" id="CLU_868950_0_0_1"/>
    <dbReference type="InParanoid" id="W4K194"/>
    <dbReference type="OrthoDB" id="3261949at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="320" mass="34297" checksum="2FFFE91A63129C07" modified="2014-03-19" version="1">MRSGGMDIFFSYENVYLDAERPSVLIENDAEVGDFRLFEADTNTPDDNGEGAGELSLTDHDLDEPRHLSDATGTTLDAQAPNLPSMVLAADDGSITFTFNRFRPYDLLYPPRPASASGMSSAPVLGATTDTPAADAEGAVNEDPSLVPNTVSLPADFVADVFEDHTIWDLPRTISDIDGTAERNDEVPDDAHLTLHKDEGASDLTPPVPLDDIAPDHGVSAGEDSSMIVAVAQEEATEGALLHIISTPERSSESDPDPSPFPEVEQDAEPPFMTDGRGRVVWSHANAKQGAPTTTGRSRRRTEATDRIDVGEREVVQGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1L5</accession>
    <name>W4K1L5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M50B-like-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_104303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549262.1">
        <property type="nucleotide sequence ID" value="XM_009550967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1L5"/>
    <dbReference type="GeneID" id="20665986"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_104303"/>
    <dbReference type="eggNOG" id="ENOG502SIMS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066780_0_0_1"/>
    <dbReference type="InParanoid" id="W4K1L5"/>
    <dbReference type="OrthoDB" id="40823at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049500">
        <property type="entry name" value="Peptidase_M50B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979">
        <property type="entry name" value="OS02G0221600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979:SF2">
        <property type="entry name" value="PEPTIDASE M50B-LIKE-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13398">
        <property type="entry name" value="Peptidase_M50B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="28785" checksum="4EB9B68C8D1AA155" modified="2014-03-19" version="1">MSTRPPIAPKIHMSPIQPTHDQVPVLYVIVVYAVILFALWNIPGARVVINPLKLFAIGWHEMCHAIVAVLTGGSVTKMTIDPIMGGCTQVDGGHPLSILSAGYIGSTLLGAIFVLGGFDTLVAKILSFVAGVGIIAPLALVRDKLRVQTILLTLIYEALLIGFWFIDHGQALRWYILFLGINHIFYAVWDVTDDKFFRKPNESDATQFSLLYPKVPPHVWAIFWISFQVAVLIAFVLIGIASFKRTTDQMYLEASHFLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4K244</accession>
    <name>W4K244_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_440850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548426.1">
        <property type="nucleotide sequence ID" value="XM_009550131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K244"/>
    <dbReference type="GeneID" id="20675309"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_440850"/>
    <dbReference type="HOGENOM" id="CLU_2441132_0_0_1"/>
    <dbReference type="InParanoid" id="W4K244"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="90" mass="10488" checksum="6C5D61B66D9036A1" modified="2014-03-19" version="1">MIREKKRERWMYICICGLMGRQGMAGEIAYIPSRLGVLYRGYDNNNSNNNGSASRVESREDADEWVSGLGLQKMSRRAYDMQRRLLPKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2I9</accession>
    <name>W4K2I9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_103432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548567.1">
        <property type="nucleotide sequence ID" value="XM_009550272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2I9"/>
    <dbReference type="STRING" id="747525.W4K2I9"/>
    <dbReference type="GeneID" id="20665905"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_103432"/>
    <dbReference type="HOGENOM" id="CLU_2164362_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2I9"/>
    <dbReference type="OrthoDB" id="3062108at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="111" mass="12785" checksum="7E12691BF2DB8747" modified="2014-03-19" version="1" fragment="single">QQQQQQQQQQPQHTQSHQQSAQMHPQQSPYSLRSHPDAMPPPPPPHPHSQQRAMHSPPGYPHMAMHDAPPPPNDRRADEAMGEPDEAWRRPMPYAERRRAGKHTKRVVVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3L2</accession>
    <name>W4K3L2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_418341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547080.1">
        <property type="nucleotide sequence ID" value="XM_009548785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3L2"/>
    <dbReference type="GeneID" id="20673469"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_418341"/>
    <dbReference type="HOGENOM" id="CLU_2705095_0_0_1"/>
    <dbReference type="InParanoid" id="W4K3L2"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW80314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="73" mass="8421" checksum="5C319F42654CDDDB" modified="2014-03-19" version="1">MVYTSHSVRPAVSFFRSFRLDTPAADILNPHFCKIRVPRSAYPDANTHVGARHRPSTRFIRGSLHLHCKRIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4E4</accession>
    <name>W4K4E4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_427383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546995.1">
        <property type="nucleotide sequence ID" value="XM_009548700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4E4"/>
    <dbReference type="GeneID" id="20674205"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_427383"/>
    <dbReference type="HOGENOM" id="CLU_1004947_0_0_1"/>
    <dbReference type="InParanoid" id="W4K4E4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="277" mass="31007" checksum="7A0DB42679C77389" modified="2014-03-19" version="1">MSLSTPRPSPPPSPLSARTRLRLRSEAACYPPAYHLQPMLRPHTNYREENATHASSIPPLMRAHATPQRHAPAFACDPHPPARVLSIPHPSPLAHARPPPSAFNPLDHLGPRIYPRLRPTSAPTCLFQPRMHDLSAPPLVDPHSFLHRPASCQDLTLHPAHARPLFRQPSRPRPSLTGWRQSKRKRKQRQRQRDELGRRMGMDDEDDERHEVPPRTSCWDSASTASPLIPVYRQPSCPTTLAPPPPPTRSIITDLDDTPGLAQVTSAIQACKLRAHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4Q2</accession>
    <name>W4K4Q2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_28762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546889.1">
        <property type="nucleotide sequence ID" value="XM_009548594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4Q2"/>
    <dbReference type="GeneID" id="20669296"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_28762"/>
    <dbReference type="HOGENOM" id="CLU_2794366_0_0_1"/>
    <dbReference type="InParanoid" id="W4K4Q2"/>
    <dbReference type="OrthoDB" id="3230169at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="66" mass="7002" checksum="438A1A3D7AC5F63C" modified="2014-03-19" version="1" fragment="single">MRQSVASSRSSHVPGQAPNAAATARLTEKKKEFEAVSAFDRASAMFLKRIEGLADDCDIMADAGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4K548</accession>
    <name>W4K548_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_247509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547633.1">
        <property type="nucleotide sequence ID" value="XM_009549338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K548"/>
    <dbReference type="GeneID" id="20669175"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_247509"/>
    <dbReference type="eggNOG" id="ENOG502R7K2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143910_0_0_1"/>
    <dbReference type="InParanoid" id="W4K548"/>
    <dbReference type="OrthoDB" id="3230534at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="120" mass="13214" checksum="BF257DAEC6D5C3D3" modified="2014-03-19" version="1" fragment="single">EDTPAARLRALLARVPNSSSYSSQTQLLHEPAPHPPSELDSDFDTPRWNTTAASVARESLKDLFSNALRDSGDSPQTGNGRRRNSIGASELDDSPRVEKVAEERAKNKGKRRTLSDEELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5E9</accession>
    <name>W4K5E9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_116059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547660.1">
        <property type="nucleotide sequence ID" value="XM_009549365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5E9"/>
    <dbReference type="STRING" id="747525.W4K5E9"/>
    <dbReference type="GeneID" id="20666508"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_116059"/>
    <dbReference type="eggNOG" id="ENOG502SNG9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064337_0_0_1"/>
    <dbReference type="InParanoid" id="W4K5E9"/>
    <dbReference type="OrthoDB" id="423313at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005796">
        <property type="term" value="C:Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF5">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="281" mass="30871" checksum="C9ACC161146CD0CE" modified="2014-03-19" version="1">MSPSSSLPLPVIYSSDPSPRFSPSPSFASLVDIIHPRKSRQRTTFLALFALIILSLYIFLVAQPSLIAPIALKQSDENNAPWRHVANSYVMKHRKAAAQVVSQRPQVSLDTPQELAAVTSFMAALPQNVIPITVDPSLPIDPQLVLDFDTRSPRAPAEVAEVVNDVWTRNPVVLFSKLHSPVSREIKHLIYDMKLRPSPTVFEVDQRAHALCPREADADVVVPLLYRLTSSSALPILLVGGKPVGSIEDIRALSENGELRRMVAESGAVIDGAQKKKKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5J8</accession>
    <name>W4K5J8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_385820</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60876"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:60877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. NudC subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="4"/>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547778.1">
        <property type="nucleotide sequence ID" value="XM_009549483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5J8"/>
    <dbReference type="FunCoup" id="W4K5J8">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K5J8"/>
    <dbReference type="GeneID" id="20672256"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_385820"/>
    <dbReference type="eggNOG" id="KOG3084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_0_2_1"/>
    <dbReference type="InParanoid" id="W4K5J8"/>
    <dbReference type="OrthoDB" id="10249612at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006742">
        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03429">
        <property type="entry name" value="NUDIX_NADH_pyrophosphatase_Nudt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049734">
        <property type="entry name" value="NudC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001299">
        <property type="entry name" value="PRK00241.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF6">
        <property type="entry name" value="NAD-CAPPED RNA HYDROLASE NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="254"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW81103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="457" mass="49665" checksum="E02AF6106914ED68" modified="2014-03-19" version="1">MAETYVNFLGGSPLNRLSWLRTSQSFLNSIAASPATRWIVFKRGEPLIVSRVDSGVSLARLTTADVRPLLGSEPFFGQGQNDGEIAAPDVHVLEAARFRGAPIVFLGLDEPLGDSALALPPPTSDVNSGSQDPQVTAHNFKGTPYFSLDVSGVTDAEIEAVLQGSEAGNGAQIQFSEPRAATRGFSMFDAALFASARSMVDWNDRNKFCAGCGSPVYSLWAGWKLTCSSLVPWADNRNRKPCPTVKGLHNFQHPRTDAVVIMAVVNEADDKILLGRNKKFPAKFYSTLAGFMEPGESFEDAVKREIWEEAGVKVWNVTYHSTQPWPYPASLMIGFYATGDPAQPIRTDLDNELDDAQWFTREQVLAVLAHEEGTTFTRKDYKQMNDIVDGKNSAQDVDALAGDAAANVAAQLKPARPTVEELAFRVPPISAIAGVLIYEWAHGKPPPVPAAVPKGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5U2</accession>
    <name>W4K5U2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="4 11">2.7.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_410039</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the APS kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="4 11"/>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547436.1">
        <property type="nucleotide sequence ID" value="XM_009549141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5U2"/>
    <dbReference type="FunCoup" id="W4K5U2">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K5U2"/>
    <dbReference type="GeneID" id="20672828"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_410039"/>
    <dbReference type="eggNOG" id="KOG0635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046932_1_0_1"/>
    <dbReference type="InParanoid" id="W4K5U2"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000212">
        <property type="entry name" value="Adenylyl-sulfate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003013">
        <property type="entry name" value="PRK03846.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055">
        <property type="entry name" value="BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055:SF1">
        <property type="entry name" value="PAPS SYNTHETASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APS kinase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW80720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="199" mass="22235" checksum="62959B7BB31F1817" modified="2014-03-19" version="1">MSTNITFHPGSVDVAERVDLLKQKGVTIWLTGLSASGKSTIACALEQHLLHLHKFTYRLDGDNVRFGLNKDLGFDEKSRNENIRRIGEVSKLFTDASCITLTAFISPYRVDRLVAREIHDKAGLGFVEVFVDASLSTVEQRDPKGLYKKARAGEIKEFTGISAPYEAPENPEIHIKTDQCDITEAVRIIADYLVAHNYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4K693</accession>
    <name>W4K693_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_173027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546005.1">
        <property type="nucleotide sequence ID" value="XM_009547710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K693"/>
    <dbReference type="GeneID" id="20668417"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_173027"/>
    <dbReference type="HOGENOM" id="CLU_2942024_0_0_1"/>
    <dbReference type="InParanoid" id="W4K693"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="60" mass="6602" checksum="D3EBBAF67F9DD766" modified="2014-03-19" version="1">MSIPPIDGFISVENHASTYQDAGSRRCCNAGALVGRDDPVGTVMRSHCQCLHVFLPVWWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6M0</accession>
    <name>W4K6M0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_317507</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546120.1">
        <property type="nucleotide sequence ID" value="XM_009547825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6M0"/>
    <dbReference type="GeneID" id="20670423"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_317507"/>
    <dbReference type="eggNOG" id="ENOG502S3G3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_676251_0_0_1"/>
    <dbReference type="InParanoid" id="W4K6M0"/>
    <dbReference type="OrthoDB" id="8955945at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
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</entry>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546400.1">
        <property type="nucleotide sequence ID" value="XM_009548105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7T2"/>
    <dbReference type="GeneID" id="20676156"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_451505"/>
    <dbReference type="HOGENOM" id="CLU_915450_0_0_1"/>
    <dbReference type="InParanoid" id="W4K7T2"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="304" mass="32841" checksum="4B9995387EC4E495" modified="2014-03-19" version="1">MVVVAGLAEIKVAASTSARRTSRKGKRETSAEDEMLQTRGAATDTLHCQSEYAPFRTQYGATYGYETLPEYGVNHPYEAGSGPSPTASTLSIGPICVAHSLANHRLAPKQISHPGAAPDHVSVQTAHQRRAGGDEDEDRAPKRPRHAVDPAPPDPRTDLVTSQQCPPDHRIRRLKRGLARGGDPAAQRALARVGGRRLPRPRREGGLRDGELRSPLEAIRGLIEAGRSQSDDIEDGIDRWVKQNEGIAIDPTPSALHFLAALCNAALDPAISIVSVYTLAVTYRGVPIKRDADGHSYTNTARNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8H1</accession>
    <name>W4K8H1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Heme oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_439857</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546012.1">
        <property type="nucleotide sequence ID" value="XM_009547717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8H1"/>
    <dbReference type="STRING" id="747525.W4K8H1"/>
    <dbReference type="GeneID" id="20675198"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_439857"/>
    <dbReference type="eggNOG" id="KOG4480">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057050_1_0_1"/>
    <dbReference type="InParanoid" id="W4K8H1"/>
    <dbReference type="OrthoDB" id="652091at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720:SF0">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="244"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW81351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="37349" checksum="2669E66C17F9FE09" modified="2014-03-19" version="1">MAIIDEAPQFDLDLSLPIATLLRSGTAAAHQTAETSAGAGWLTRGELDKEEYIRFLIMLWHVYDELERALEQHASHPVLNPTYNPTLLARAPALLADISHLLSVPTSDVPAHPLFTALDAPAPRGLAEYTSRLRALASARDPAPLLAHAYVRYLGDLSGGQVIRRRVARAYGLEDDGGAGVSFYEFAKLGGGAGATVGDMKKIKEWYRDGMNAGVGDDRDLKVTILAEANKAFVLNGGLFESLKPPSSPPSSPPSPIDSTSPHSHFGNPNTPAVSSFPREEEKPKEIAVQILQTHSESEGTYSVSGVLSFIAAMCLAHFILVVGGFTGTRGWEKLEAVENWISGYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8T7</accession>
    <name>W4K8T7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_427287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546719.1">
        <property type="nucleotide sequence ID" value="XM_009548424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8T7"/>
    <dbReference type="GeneID" id="20674193"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_427287"/>
    <dbReference type="eggNOG" id="ENOG502R18J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082469_0_0_1"/>
    <dbReference type="InParanoid" id="W4K8T7"/>
    <dbReference type="OrthoDB" id="3051534at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="264" mass="28624" checksum="3B017BEE59FC41B4" modified="2014-03-19" version="1">MSDPAPNKTQDPLIASTVSNDQLQNLASGVSTLTKGIADLRTPLQTPLQAPPKRTVAPALALAPAPVAPTAPDVISLNVPSFATLASINPTVTVSPSLLSQFHLVELAVIKAIVNHNFRAADLYKLDPQHRGRGGWRAHDRDAMELGSLSSVIIPLGTYFSILGFAIAPANPSIGPIVSGFWAYIASLMQFASQYEWAAIHLYHVDFFTTRRREMQFGDYSQWGRIDVDILSRRLLGHNKVARPDALTPGILCMVFSLERSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2024-07-24" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9I1</accession>
    <name>W4K9I1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anaphase-promoting complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_408781</name>
        <name evidence="1" type="ORF">HETIRDRAFT_412624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544759.1">
        <property type="nucleotide sequence ID" value="XM_009546464.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553014.1">
        <property type="nucleotide sequence ID" value="XM_009554719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9I1"/>
    <dbReference type="GeneID" id="20672718"/>
    <dbReference type="GeneID" id="20673050"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_408781"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_412624"/>
    <dbReference type="HOGENOM" id="CLU_1839878_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW75618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15625" checksum="CDB7438BEB8A4956" modified="2014-03-19" version="1" fragment="single">SDLKQSVSALKICLAGVTGPEQFAFYNLLSMLLEAHFRRLGQQEDIQLSIEACRAFLAESGIHDPMIQMIVFWRLSKALVAYHDATRDGEMLDKAAGVGRDAVRLCGEDHLLLAMILALQGMILRQRFVVHENEEDLKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9I3</accession>
    <name>W4K9I3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_426128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544805.1">
        <property type="nucleotide sequence ID" value="XM_009546510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9I3"/>
    <dbReference type="GeneID" id="20674080"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_426128"/>
    <dbReference type="HOGENOM" id="CLU_132424_0_0_1"/>
    <dbReference type="InParanoid" id="W4K9I3"/>
    <dbReference type="OrthoDB" id="3267098at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="109" mass="12432" checksum="34CB069797FE1DA4" modified="2014-03-19" version="1">MPNNPAENDEDWEGYYINMFVDRDMFMRFRGGGIATQVLEEPSDEAVNEQGGGAEDNNSEEEYKEEKGEEGPLMEEEEEDSDDDLDPLPKGDGRERDERVLAEEGYGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAV7</accession>
    <name>W4KAV7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_242409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544858.1">
        <property type="nucleotide sequence ID" value="XM_009546563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAV7"/>
    <dbReference type="STRING" id="747525.W4KAV7"/>
    <dbReference type="GeneID" id="20668928"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_242409"/>
    <dbReference type="eggNOG" id="ENOG502SCY7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077575_1_0_1"/>
    <dbReference type="InParanoid" id="W4KAV7"/>
    <dbReference type="OrthoDB" id="2205812at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="19960" checksum="5404AD1CE8D9F2DB" modified="2014-03-19" version="1" fragment="single">LINLFADDTTIYLGQEDRYNDLQDILSQWCTISGAKFNSTKMEIIPTGPTDHRARVLMTCQLHPDDEPLHTSIQIAPDGQAVHSLRAWIGNKIDNMMPWEPILDKINTHLNWWSLGHPTLDGKQLIVQMVVGASTQYLRKVHGMPTRIEEALVKTIRNFVWNENIPQIGLQYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4KB44</accession>
    <name>W4KB44_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_474137</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545308.1">
        <property type="nucleotide sequence ID" value="XM_009547013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KB44"/>
    <dbReference type="STRING" id="747525.W4KB44"/>
    <dbReference type="GeneID" id="20677550"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_474137"/>
    <dbReference type="eggNOG" id="KOG0141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_4_4_1"/>
    <dbReference type="InParanoid" id="W4KB44"/>
    <dbReference type="OrthoDB" id="2588832at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00567">
        <property type="entry name" value="ACAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW83018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="519" mass="57341" checksum="C8CD703AE1FBD997" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBB9</accession>
    <name>W4KBB9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_417135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545424.1">
        <property type="nucleotide sequence ID" value="XM_009547129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBB9"/>
    <dbReference type="STRING" id="747525.W4KBB9"/>
    <dbReference type="GeneID" id="20673386"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_417135"/>
    <dbReference type="eggNOG" id="ENOG502SM5A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006344_16_0_1"/>
    <dbReference type="InParanoid" id="W4KBB9"/>
    <dbReference type="OrthoDB" id="3187773at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW83142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="126" mass="14183" checksum="B9E6E1D603D2DF17" modified="2014-03-19" version="1">MHQVTPLTAYSRNDCIFTEKDPELDGFRGLHAARVVIFFSFKHQQITYPCALVEWFVPVGDKPCSNTGMWIVEPQIGLGGGRITSVIHVDSILRGAHLIDFTDTLDAFAAYYVNKFIDHHANEIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBS4</accession>
    <name>W4KBS4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_108799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544882.1">
        <property type="nucleotide sequence ID" value="XM_009546587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBS4"/>
    <dbReference type="GeneID" id="20666388"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_108799"/>
    <dbReference type="HOGENOM" id="CLU_1272448_0_0_1"/>
    <dbReference type="InParanoid" id="W4KBS4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="217" mass="23821" checksum="2E640B9570BC3206" modified="2014-03-19" version="1">MRTSPGTAHIGSLRQVESGKGATHHGLRAVRQRHRSGISSTIHSAPPTSVCTANSRLLASIEHNTTSRVCSLSFLLSAARARTHPIARARTHALEALELLQHALSHAVHVVVQQRREHLPADRDHPPPVRLARRVHDAAVDEQLEERHALRQGHRAPALRGKAGCSPSDGVRASTFIEPFSLTPDRVPSRSLWSSARMLPSALTKRSTISLRKRTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCE8</accession>
    <name>W4KCE8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CoA-transferase family III</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_444548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545306.1">
        <property type="nucleotide sequence ID" value="XM_009547011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCE8"/>
    <dbReference type="STRING" id="747525.W4KCE8"/>
    <dbReference type="GeneID" id="20675587"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_444548"/>
    <dbReference type="eggNOG" id="KOG3957">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033975_5_1_1"/>
    <dbReference type="InParanoid" id="W4KCE8"/>
    <dbReference type="OrthoDB" id="16747at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050509">
        <property type="entry name" value="CoA-transferase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228:SF5">
        <property type="entry name" value="ALPHA-METHYLACYL-COA RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228">
        <property type="entry name" value="SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="36481" checksum="00C1CAFC62BFB762" modified="2014-03-19" version="1">MTSPPTNAGPLAGIKVIEFAGLAPVPFAGLILSDFGASVTRIDRCTPHTIIHESLNTDILCRNKRSIAVDLKSPKGLEIVRRLVRNADVLIDPFRPGVLEKTGLGPEVWFGKDGKGEEQNDRLIYARIAGFRRDGPHKDMAGHDLNYLALSGVLSLLPGTEEKPAFPLNLLADFAGGGLTCALGILLALFERTHSGRGQIVDTDMVSGVRYLSTFPFLHAYLRTPMFANPALPRQSNILDGGAPYYGIYTCADGRHIAVGCLEPRFFMIFLERFMDGVPSAWLEVQKKRGWVPDAGSQSRKEEWGHLRAFLERGFRLLERDEWTKVPTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCS8</accession>
    <name>W4KCS8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_170042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543366.1">
        <property type="nucleotide sequence ID" value="XM_009545071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCS8"/>
    <dbReference type="GeneID" id="20668253"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_170042"/>
    <dbReference type="HOGENOM" id="CLU_1791461_0_0_1"/>
    <dbReference type="InParanoid" id="W4KCS8"/>
    <dbReference type="OrthoDB" id="5569250at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="61"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="153" mass="17850" checksum="613E7689357B167F" modified="2014-03-19" version="1">MFYLPWKWHKSTAIPRPPPQYSNTPPHVASVSQPKKFDEWGINTQITEESNIRIPFSKLDLQKSHIQCGIRATNMLNSALNVNHVINMHIVDDVATIWWYDRQGIIRSQAMNFIQDLPRFSVLLLTFQRFTLEDWGIDAVLNRKAHKFYDAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCT0</accession>
    <name>W4KCT0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_439661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545427.1">
        <property type="nucleotide sequence ID" value="XM_009547132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCT0"/>
    <dbReference type="FunCoup" id="W4KCT0">
        <property type="interactions" value="625"/>
    </dbReference>
    <dbReference type="GeneID" id="20675172"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_439661"/>
    <dbReference type="eggNOG" id="KOG1150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070940_1_0_1"/>
    <dbReference type="InParanoid" id="W4KCT0"/>
    <dbReference type="OrthoDB" id="342454at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620:SF1">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="48"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW83145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="226" mass="25875" checksum="23CDC31016D73ADB" modified="2014-03-19" version="1">MASSSSSSNNAPPSIISDAELEKLLNREASAFQRELEVERILKAFKLNPYDILDLDETAKPEDVKRKYRQLSLFIHPDKTPHARAPEAFDILKKAESELSDTAKREELDATITQARSVLLKALSLPPNTPDDHPKLKGLEPTFKVQLRIKSKELLIDEEVRRRKAVKMNLANEGFEARKKEEEVTAKKRKAEDDAKWEETREQRVGSWRSFTNNSKKKKQKVNILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDB4</accession>
    <name>W4KDB4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_450911</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545564.1">
        <property type="nucleotide sequence ID" value="XM_009547269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDB4"/>
    <dbReference type="FunCoup" id="W4KDB4">
        <property type="interactions" value="357"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KDB4"/>
    <dbReference type="GeneID" id="20676090"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_450911"/>
    <dbReference type="eggNOG" id="KOG0332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="InParanoid" id="W4KDB4"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17963">
        <property type="entry name" value="DEADc_DDX19_DDX25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="118"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="299"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW83295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="482" mass="53459" checksum="48B25330CB132CD1" modified="2014-03-19" version="1">MEKDADGFYTPVVPADPAPPAEPAPAPPTEPPTPVPDPPADEAVSPDKIGSPSQSATDLIKSTFEVHVTLADQQQDPNSPLFSAKTFEELGLHGDLLKGLFDMGFTKPSKIQERALPLLLKNPPQNMIGQSQSGTGKTAAFVLTMLSRIDFSKDKPQALCLAPSRELARQIMSVIGTMGKFTPVQTEYAIKDHLPRDATKVTAHIIVGTPGTMMDLIRRKVIDVSEVKVFVLDEADNMLNEDGLGDKTLRIKNFLPRGGGTQIILFSATFPDHVRKYANNFAPNANKIELKRNELSVDSIRQFYMDCKTEEQKYDILVLLYHILTIGQSIIFCEHRHTADRISQRMTAEGHKVASLHGAKDGNERDAIIDGFRAGKEKVLITTNVIARGIDILQVNMVVNYDLPLLYDGGNRNTRQPDVETYIHRIGRTGRFGRKGISINFVHDKLTWGQMQQIEAATGKKIIRIETDDLDAMEEQMKKVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDU8</accession>
    <name>W4KDU8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_417380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545736.1">
        <property type="nucleotide sequence ID" value="XM_009547441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDU8"/>
    <dbReference type="STRING" id="747525.W4KDU8"/>
    <dbReference type="GeneID" id="20673400"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_417380"/>
    <dbReference type="eggNOG" id="ENOG502SKHB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002498_0_1_1"/>
    <dbReference type="InParanoid" id="W4KDU8"/>
    <dbReference type="OrthoDB" id="2687259at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="925"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="934"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="985"/>
            <end position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1003" mass="115344" checksum="B2D218B637C3DC64" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KE68</accession>
    <name>W4KE68_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_170638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543856.1">
        <property type="nucleotide sequence ID" value="XM_009545561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KE68"/>
    <dbReference type="GeneID" id="20668299"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_170638"/>
    <dbReference type="HOGENOM" id="CLU_2705091_0_0_1"/>
    <dbReference type="InParanoid" id="W4KE68"/>
    <dbReference type="OrthoDB" id="3241054at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW84152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="73" mass="7832" checksum="91F4118810FE4491" modified="2014-03-19" version="1">MHLTVTSTQSPACQSTSSDLSSLFRVLWVAVSSPQSPMGCKYVFAGLTQPLSHAVITASPFFLLAFSITKLHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEK2</accession>
    <name>W4KEK2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CP-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_381689</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543933.1">
        <property type="nucleotide sequence ID" value="XM_009545638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEK2"/>
    <dbReference type="STRING" id="747525.W4KEK2"/>
    <dbReference type="GeneID" id="20672082"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_381689"/>
    <dbReference type="eggNOG" id="KOG2484">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011106_5_1_1"/>
    <dbReference type="InParanoid" id="W4KEK2"/>
    <dbReference type="OrthoDB" id="10266128at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014813">
        <property type="entry name" value="Gnl3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF30">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08701">
        <property type="entry name" value="GN3L_Grn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW84279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="21752" checksum="7F154AB038E69282" modified="2014-03-19" version="1">MALQVLRASSLSTLRQTRLAFSTSTWRAEQALQPAISSTTPQSEASSSSQDGPPEAPPGLYSPFRPTSIAAKLSDPQFQLHVKCTHNNTIITLTSPENRPVQRGIWSGGLCGFKGVNRSGYEAAYQCAVRAFKRTEELMLENPVMKLELCMKGFGQGRDAVSKALMTSEGEKVRKVVNRITDKSPIKIGGTRAKKARRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGQ8</accession>
    <name>W4KGQ8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_414181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541935.1">
        <property type="nucleotide sequence ID" value="XM_009543640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGQ8"/>
    <dbReference type="GeneID" id="20673158"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_414181"/>
    <dbReference type="HOGENOM" id="CLU_056208_0_0_1"/>
    <dbReference type="InParanoid" id="W4KGQ8"/>
    <dbReference type="OrthoDB" id="3244593at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="282" mass="32838" checksum="B9C9B70A737535D2" modified="2014-03-19" version="1">MKRHYKEYAEFCCEEADIPKSKHAHIVEAAQRPLQELMIKVLVAVNAPISEEEGLSALQTFIVSETYKEFIKAPVDIIMLDPKLSGFKLGFTSRLLHHIRVNPGQYHIPHRLIPFLTTKVFATAISRSIIASRAEIKRKLKELFHKKANIYALVKKLVGNLKSQVTVTEDHWYRWAWVHNAYIRFENLNLHQKTFWNWVNNELSLHRQSVKNMPKPARSKALKGMFKQAFDKHLNAYPPSKRLTASTQRETLWQTNATHSISAMEEYDLHDIPNDIDEEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4KH15</accession>
    <name>W4KH15_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cerato-platanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CerPla1</name>
        <name evidence="5" type="ORF">HETIRDRAFT_146085</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cerato-platanin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542032.1">
        <property type="nucleotide sequence ID" value="XM_009543737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KH15"/>
    <dbReference type="GeneID" id="20667117"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_146085"/>
    <dbReference type="eggNOG" id="ENOG502SQTH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111635_0_0_1"/>
    <dbReference type="InParanoid" id="W4KH15"/>
    <dbReference type="OrthoDB" id="4898945at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22778">
        <property type="entry name" value="DPBB_CEPL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010829">
        <property type="entry name" value="Cerato-platanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07249">
        <property type="entry name" value="Cerato-platanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844290" evidence="4">
        <location>
            <begin position="20"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW85153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="138" mass="14175" checksum="75C055700CC44CA1" modified="2014-03-19" version="1">MKFTFALASLAVLASTAFATDVRYDETYDNANEPLTDVACSDGTNGLINKGFSTLGSLPSFPNVAAVQAIAGWNSPSCGTCWEVTYNGRSVLVTGVDHAGDGINMSLEAMNTLTNNQGVALGTVSATVTQVAASQCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KH54</accession>
    <name>W4KH54_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_18154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541720.1">
        <property type="nucleotide sequence ID" value="XM_009543425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KH54"/>
    <dbReference type="GeneID" id="20668609"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_18154"/>
    <dbReference type="HOGENOM" id="CLU_2365243_0_0_1"/>
    <dbReference type="InParanoid" id="W4KH54"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="100" mass="11341" checksum="7BE2FC32962DA737" modified="2014-03-19" version="1" fragment="single">DALSGRPDLKQGVKLDNKNQILLKSQLFVKSATGRGTVEMLDRQLMQELKNITAKDKEVMEVIEVIKASGPRTLSKGLQKWNLEDDLIWHRGKIYVPPND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHF2</accession>
    <name>W4KHF2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_63218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543289.1">
        <property type="nucleotide sequence ID" value="XM_009544994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHF2"/>
    <dbReference type="STRING" id="747525.W4KHF2"/>
    <dbReference type="GeneID" id="20678631"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_63218"/>
    <dbReference type="eggNOG" id="KOG1576">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_7_2_1"/>
    <dbReference type="InParanoid" id="W4KHF2"/>
    <dbReference type="OrthoDB" id="5286008at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045290">
        <property type="term" value="F:D-arabinose 1-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070485">
        <property type="term" value="P:dehydro-D-arabinono-1,4-lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686:SF1">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="45"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW84491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="395" mass="43134" checksum="4B4E86B354717742" modified="2014-03-19" version="1">MSSALDLPEPVFYLPPLNSISDDEDDAPKQGRPLEEIGPLRVSSLVFGAAAWSHFYNDEAYLASDIPIRTTRLALRYGIRSFDTSPYYGSSEIVLGTALKGLEAEFPRESYKLMTKCGRYGSSDFDYSPKTIRRSVERSLARFHTTYLDTVYLHDIEFVATPVALRTEGVHLGALGSEAEAYGLNEGQEAKVWGEGDQKILDAVAELRKLQEEGVVKSIGITGLPLPTLLRLAILVLNTAPYRPLDAILSYSHLTLQNDSLLSFLPAFIRRAKISQVLTASPLSMGLLTATPPAWHPASSDMRAASAEAVERCAEWEGGLPSVSIGWAIKSAEGGTGSREGKMPTVVGLSNLREVHQAVAIWRQVKDGGEEEARQQYAEAAVGAFKANGTKDWTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHG5</accession>
    <name>W4KHG5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_310375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542142.1">
        <property type="nucleotide sequence ID" value="XM_009543847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHG5"/>
    <dbReference type="GeneID" id="20669777"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_310375"/>
    <dbReference type="HOGENOM" id="CLU_915449_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHG5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="304" mass="32913" checksum="56A0CC7EBBC1DC81" modified="2014-03-19" version="1">MRSPVPPTHTHPPIHISLTVSEKVQVERRWFAVSLSSKAGPIAIYALDAHRPEAAFSAAHPTSLQLFGFNKIQAAAASIARTERMIRRRFTREYASLSSSIDLVQVPEATPVAEVEAAVDGEVEATVENDVVAVESMEQVGAVAAVALVNGEDTVEGEEAVVSEVQCVIPAESPQGKGTERQGLSKDKNEDTLQRRTIPDLSLKGSFLMGLERLHDQADFEPDDPRSPGQGKLKARSRRKAIIHVKPVQTGSVRRWVIRRRNASSFLSDCRSISPASSSVTVAGKSRSSFAWTARGVVSVSIIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHH4</accession>
    <name>W4KHH4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 8 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_63265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543290.1">
        <property type="nucleotide sequence ID" value="XM_009544995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHH4"/>
    <dbReference type="STRING" id="747525.W4KHH4"/>
    <dbReference type="GeneID" id="20678632"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_63265"/>
    <dbReference type="eggNOG" id="KOG1950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077164_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHH4"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="362" mass="40900" checksum="F29B014B6288D52C" modified="2014-03-19" version="1">MTNSHSDYIPLFNGNPAAYSKGRQRWFWGLCTGLGFLALINIAVLAKFFLSSKSVATPLDDYQILKPKFTTGRQDRISTNPTDPSTRAVVSSLYTDSFAYPVATLGHSISASNVTARRILMYIPSQVSEHALCIVRSAGWELHPVARIAPPHEGHGVGSRFEDQYTKLNLWGLDRLGIESAVYLDADTLVRKPFDELFDLPFEFAAVPDVFPDDKDGGFKLGFNAGVLVLRPNNDTLVNMIATLEHARYLPGEAEQAFLNLYYGGEALRLPYVYNSNLAIKLRSTELWKAMMDDIRVVHYTTVKPFDFLGKEVPSLERAKELLESRKAERGGIFREELGWWEETWKKTLREPELQKCLEQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHP6</accession>
    <name>W4KHP6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_101042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542112.1">
        <property type="nucleotide sequence ID" value="XM_009543817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHP6"/>
    <dbReference type="GeneID" id="20665728"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_101042"/>
    <dbReference type="HOGENOM" id="CLU_169134_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHP6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="75" mass="8472" checksum="4A1FAA327822F36F" modified="2014-03-19" version="1">MTVMEVGVAVVENEADIFARYTLAMPLFNFLLVTLPRNDGPSILFTALTAMHQMTYVGFAVHLNDMLSVLRLRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHX8</accession>
    <name>W4KHX8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_309468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542153.1">
        <property type="nucleotide sequence ID" value="XM_009543858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHX8"/>
    <dbReference type="GeneID" id="20669680"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_309468"/>
    <dbReference type="HOGENOM" id="CLU_704101_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHX8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="392" mass="42273" checksum="FFA29DBF783838D8" modified="2014-03-19" version="1">MGGAKATLVTPNSIKPRRSPLFLSITLSSSPPPPCPLSCTSLLTILSASSFICTGTFHPCRSPLFPLNFDALQVIRHDRLKHDVKLIGTIAFKHDSNFTGRVVSSGDTALGSVALVCGIGLYRSLEVASMSGCWCVSSTCLGSVLPALLVLLLFLSLVVLVSYHYLLRFDVLGCGLLALCCVVCSLWVPVSLCPLFDLACLLCLTCSFSSSPCLLSWPSLFLLIAVACFLCFTWSSLSPLLAVALILVSDVSCQSLLVSVFVLAYLNLIFLLVYLVLAVIHSRWPWSVSATLSISLGSLRFLSISFWFILATLSAHLGPAPPDTTISICKRSGRQLGGVRPRCVSIRLCIISFVGETLAIDNEALAPYQQRPLQGSSITHHYATQLRINVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KI67</accession>
    <name>W4KI67_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_116903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544391.1">
        <property type="nucleotide sequence ID" value="XM_009546096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KI67"/>
    <dbReference type="STRING" id="747525.W4KI67"/>
    <dbReference type="GeneID" id="20666526"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_116903"/>
    <dbReference type="eggNOG" id="ENOG502RC50">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_484019_0_0_1"/>
    <dbReference type="InParanoid" id="W4KI67"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="563" mass="63125" checksum="62B7ADCEEACECAF6" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4KI81</accession>
    <name>W4KI81_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L-arabinitol 4-dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_154644</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-arabinitol + NAD(+) = L-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16381"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17399"/>
            <dbReference type="ChEBI" id="CHEBI:18403"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.12" evidence="8"/>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541920.1">
        <property type="nucleotide sequence ID" value="XM_009543625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KI81"/>
    <dbReference type="STRING" id="747525.W4KI81"/>
    <dbReference type="GeneID" id="20667511"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_154644"/>
    <dbReference type="eggNOG" id="KOG0024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_5_1"/>
    <dbReference type="InParanoid" id="W4KI81"/>
    <dbReference type="OrthoDB" id="2148442at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050019">
        <property type="term" value="F:L-arabinitol 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF12">
        <property type="entry name" value="L-ARABINITOL 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="11">
        <location>
            <begin position="31"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW85025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="378" mass="40600" checksum="6933C228F08CBA7A" modified="2014-03-19" version="1">MISTTTTTVTSSLQLKPNIGVFTDPQHNLWIDSASPSVEEIQRGDTLAPGEVVVQVRSTGICGSDVHFWHAGRIGPMIVEDKHILGHESAGEIVAVHESVKHLKPGDKVAIEPNIPCHACRPCLTGHYNGCENVLFRSTPPVPGLLRRYITHPAVWCHKLPDTMSFEDGALLEPLSVALAALDRSNLRLGDAAVICGAGPIGLVSLLCAKAAGAEPIVITDIDQGRLDFAKQLVSGQPGTLKTFLVERGKTEEENAAGIIQALGGVEPDVALECTGVESSIGAAIHAVRFGGTVFVVGVGKNEMKFPFMRLSTREVDLRFQYRYANTWPKAIRLVNSGLLAQVRKLVTHRFVIEDAVKAFETSADIKSGAIKVVITNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4KID6</accession>
    <name>W4KID6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_168321</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542328.1">
        <property type="nucleotide sequence ID" value="XM_009544033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KID6"/>
    <dbReference type="STRING" id="747525.W4KID6"/>
    <dbReference type="GeneID" id="20668150"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_168321"/>
    <dbReference type="eggNOG" id="KOG2726">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1015846_0_0_1"/>
    <dbReference type="InParanoid" id="W4KID6"/>
    <dbReference type="OrthoDB" id="277888at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20267">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045298">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052405">
        <property type="entry name" value="Mito_Transl_Release_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203:SF1">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203">
        <property type="entry name" value="PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="6">
        <location>
            <begin position="160"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="103"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="231"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW85469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="274" mass="31137" checksum="5B1BD67B2EB6EE59" modified="2014-03-19" version="1">MTISPSLQAAARSAYRSLYRASAATFSGDERVLRAFRDKMRHDTLAGRSQTDTQLYEQNVTLAREVADVLRKNIVQAQKIAEPSTVNGQETWKLRLTKDTELADNDSIKSPEPIPELSSRSQRKREQVQNPSSSPDSSASTVPRFYSQLKKAHKQRNVPDLKEDDLEESFVRGARRLLCSGPGGQSVNKTENNVQLLHKPTGIRVSCQETRSLELNRMFARRILLDKLDKIHNPGLSKSELQKAKQIERERRRRKKAKKQAMEKETGVDRDDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4KK42</accession>
    <name>W4KK42_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_310198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542274.1">
        <property type="nucleotide sequence ID" value="XM_009543979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KK42"/>
    <dbReference type="GeneID" id="20669762"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_310198"/>
    <dbReference type="HOGENOM" id="CLU_2996726_0_0_1"/>
    <dbReference type="InParanoid" id="W4KK42"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="57" mass="6582" checksum="E30473BC3E27FD40" modified="2014-03-19" version="1">MSPIYPLKAVGYRLEDHFRRAVKVMSLTQPTEGCATSDQRRSPLMQKTYMCEQLCKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKB6</accession>
    <name>W4KKB6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Quinone oxidoreductase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">qor3</name>
        <name evidence="2" type="ORF">HETIRDRAFT_145876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542597.1">
        <property type="nucleotide sequence ID" value="XM_009544302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKB6"/>
    <dbReference type="GeneID" id="20667104"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_145876"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_1"/>
    <dbReference type="InParanoid" id="W4KKB6"/>
    <dbReference type="OrthoDB" id="9930022at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="16"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="345" mass="37690" checksum="8F8BF0588E56BA94" modified="2014-03-19" version="1">MSRAQQQTVFRVKEKNILSGIVKCQESIPIPQPHEVLVRIHAVSLNFRDYLPFSSKYPLPVKQDVVPGSDMAGEVLSIGSAVLGFKQGDRVTANFDQNHWYGTLPDERVILAGSIDGVLQEYRIFPEMGLLHIPKHLSYEEASCWPCAGVTAWNALFGGAPLVPGQTVLFQGTGGVSIAGLILAHAAGAKTIVTSSSEDKLEIAKKLGATHVVNYKREPDWDQVVLKITDGIGAHLILDNVGAQEIERCYNCVARGGTIASIGFLGNNPEKVPDIAMLNLLKCVTLRGVYVGSKQLHEDLLRFVGANELRPHIDKVFPFEQTPEAIDYLSRGQHTGKIVIRVVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKN3</accession>
    <name>W4KKN3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_415302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543119.1">
        <property type="nucleotide sequence ID" value="XM_009544824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKN3"/>
    <dbReference type="STRING" id="747525.W4KKN3"/>
    <dbReference type="GeneID" id="20673238"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_415302"/>
    <dbReference type="eggNOG" id="ENOG502S3UW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066707_1_0_1"/>
    <dbReference type="InParanoid" id="W4KKN3"/>
    <dbReference type="OrthoDB" id="63935at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF50">
        <property type="entry name" value="UPF0659 PROTEIN YMR090W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="30161" checksum="B1EC74CFF4A92EC1" modified="2014-03-19" version="1">MNVFTIGGSCNIGYHASVRLLKKGATVTFLLRRTEVFDADEVIQEYLAKGKVRLVKGDALNKDQVQHGWAVAGKREGADGSSSEGGVDVLLFTVGKNRGVPSFHPLRGFVINPPDLCSRSALNALSTIPPEHSYPRIVAVTSVGLTPAAHASMPFALRSMYTLLLGPPHKDKRGAERVLAHCMGTKGPKETILPPDWEQIAGLPPKGVLANNVVIVRPALLTDGECRAEGLKGGYRVRSDDDLAVTGGYNVSRQDVAHFIAERVLGEEWATWAGKGVSLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKU9</accession>
    <name>W4KKU9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_423675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540468.1">
        <property type="nucleotide sequence ID" value="XM_009542173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKU9"/>
    <dbReference type="GeneID" id="20673932"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_423675"/>
    <dbReference type="HOGENOM" id="CLU_1390405_0_0_1"/>
    <dbReference type="InParanoid" id="W4KKU9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="196" mass="22584" checksum="57907E2A345406BB" modified="2014-03-19" version="1">MIKLEYNRALEEEQIKKQLQTHPIGKKLLATRLGIPQIKEAINNRIKEEQLKRKLLSLSLGRKLMDVGLKMSQIKDWADAQSKKLQEANLRKKFQGHLIRKKLIIAGFETFKIMEAVEKRGKELEGETKLKEKLQNRPIGKKLLSIGLVTPRIMEEVNKQFAQLMKRMTASSADHQKATTDTSPSKTYSEQSWTMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4KL47</accession>
    <name>W4KL47_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_32020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FRG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541734.1">
        <property type="nucleotide sequence ID" value="XM_009543439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KL47"/>
    <dbReference type="FunCoup" id="W4KL47">
        <property type="interactions" value="423"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KL47"/>
    <dbReference type="GeneID" id="20670653"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_32020"/>
    <dbReference type="eggNOG" id="KOG3962">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062276_2_1_1"/>
    <dbReference type="InParanoid" id="W4KL47"/>
    <dbReference type="OrthoDB" id="5539371at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23339">
        <property type="entry name" value="beta-trefoil_FSCN_fungal_FRG1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010414">
        <property type="entry name" value="FRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928">
        <property type="entry name" value="FRG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928:SF0">
        <property type="entry name" value="FSHD REGION GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06229">
        <property type="entry name" value="FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW86080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="199" mass="22305" checksum="3054394CAE5231B3" modified="2014-03-19" version="1">MLHPLVKGEADDEEGNLMDRVPSEVSQVWVTTRVAGSLTINLRTGVGEGKFLSCDKHGLVSADREARGPEEEWTPVVYDDGMVAFQNVYEKYLSVDEVAGQMQLRGDSDNVGFGERFYVKIQSKYKKEAHEEEKKKKEGMLGAPSMDEAGTNKIYQAWGAGKSIVSRSDRKELKQARDEGRLAEALLDRRAKLKSDRFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLA7</accession>
    <name>W4KLA7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_407691</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542641.1">
        <property type="nucleotide sequence ID" value="XM_009544346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLA7"/>
    <dbReference type="FunCoup" id="W4KLA7">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KLA7"/>
    <dbReference type="GeneID" id="20672625"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_407691"/>
    <dbReference type="eggNOG" id="KOG1842">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028545_0_0_1"/>
    <dbReference type="InParanoid" id="W4KLA7"/>
    <dbReference type="OrthoDB" id="166134at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15737">
        <property type="entry name" value="FYVE2_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.20">
        <property type="entry name" value="Rabenosyn, Rab binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021565">
        <property type="entry name" value="Rbsn_Rab-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036531">
        <property type="entry name" value="Rbsn_Rab-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11464">
        <property type="entry name" value="Rbsn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140125">
        <property type="entry name" value="Rabenosyn-5 Rab-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="5">
        <location>
            <begin position="95"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW85821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="397" mass="45028" checksum="64751DA44F6F7B9D" modified="2014-03-19" version="1" fragment="single">ARRALRDAGRIERTRLERRLEKLIALHFNAKGQASTNSRAQPSRRASSFFDIDIKELRNLDAADLWKNMMQNQITPGSKADIRAQEQSITPWENDSDVSQCPLCSASFHPITNRKHHCRLCGRIVCSLPAKRGQRPVTCSLLFIADKKTGKIEEVGEGVDYGVRRRSSMGPQNKGKEKEALIEEEKFLQGVRICRECSSILKRQQHRQEAFHVPTYARLYEAFINLEKQIEDALPVFQELLLALNNDDQPTAEASAARKRLLEAFSQYDSLAKRIRTLPTPGPGSSQDRVQAAILTRASVFLQKHMFPLRTLPKPKKPISSPITEAETPVIDPDSNLAHVLQPLLEQEALLESFVEEAKAHRKFEDVQTLKSNLREIRSEIDKVLANADYEVHRQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLG2</accession>
    <name>W4KLG2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_456613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540668.1">
        <property type="nucleotide sequence ID" value="XM_009542373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLG2"/>
    <dbReference type="GeneID" id="20676762"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_456613"/>
    <dbReference type="eggNOG" id="ENOG502SUVJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046439_1_0_1"/>
    <dbReference type="InParanoid" id="W4KLG2"/>
    <dbReference type="OrthoDB" id="3204502at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="240" mass="26400" checksum="99A95C154CDA0C0A" modified="2014-03-19" version="1">MPPPPLRPCLKIDHPSAAANSPSPFPFAACSNVLSPRVHFPPTPALTSTHLTHSSKHYDRAPIVVAPNACALPERNGRTYSPPSEPMRPSKTKAPPYAQAQAQAHAVKGSYFHPRAFEACEREPSTVPVPPFDPPPPLVPDISSSESDESDTYLTTPPDPHHYPHMPFQLPSNHHAHAPMAYPRDDKGAAMLFLPHPPSPKQERQRERERARSPSRTRGHRQTKRSEFAAPELDGCLGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLK7</accession>
    <name>W4KLK7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_380562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542996.1">
        <property type="nucleotide sequence ID" value="XM_009544701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLK7"/>
    <dbReference type="STRING" id="747525.W4KLK7"/>
    <dbReference type="GeneID" id="20672031"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_380562"/>
    <dbReference type="eggNOG" id="ENOG502SBK0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036734_0_0_1"/>
    <dbReference type="InParanoid" id="W4KLK7"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016712">
        <property type="entry name" value="Rbsml_bS1m-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11709">
        <property type="entry name" value="Mit_ribos_Mrp51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="421" mass="47287" checksum="2A327A588649F8B2" modified="2014-03-19" version="1">MLRRSKFATYDPQVAQIYTAYGGYAHRGDWGLKRPLSVRKRDKYITIQTIDSPEQQTEWRTGESESRWIRRWSEVGTEVQMRGIWDRQTVNHDWVIDSDFTLGTEDGAVLKAQKAQMQKTKDAELLAEGDRVAEAGEEQMVENTEPAEQTPLSAYNAVVPNIMAMSPKEFESYVEKLRAQRPQFKQFLKNQVQQTQAARAKDNRAMAIIVQEPFEEAQRASALLVRKAFLQHSVQEQYRDPSSRMIEQRPHRNAGLSYALASPLTNFFLVKPQPGRQITVQEKPMISFGGMVSTLAGSSDVQDNLSLRMASAKLLSTPRVVGEQPSGLEGVGLETTVRDMSEMALIRRSPHKPGSRKYVGQARTHLQSKTRRLSMTSPRSREKASSVPLRQANSASTKVASTTALLDTLNRIVKVGAVGHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLL5</accession>
    <name>W4KLL5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Voltage-gated potassum channel beta 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bKv1</name>
        <name evidence="5" type="ORF">HETIRDRAFT_58715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540381.1">
        <property type="nucleotide sequence ID" value="XM_009542086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLL5"/>
    <dbReference type="FunCoup" id="W4KLL5">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="GeneID" id="20678447"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_58715"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_1"/>
    <dbReference type="InParanoid" id="W4KLL5"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF2">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="31"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW86743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="362" mass="40572" checksum="ABBFC4C42E413CF9" modified="2014-03-19" version="1">MSQPVKLEFQPKNMPFRTLGSSGLRVPVFSLGGWLTIGGTVFGDPVKEIIKTAFENGINMFDEAENYADGQSEIEMGRVIKELGLRRTDLVVTTKLFWGSERGHNHMGLSRKHIIEGTRASLKRLQLDYVDVIFAHRPDPTTPIEETVRAFHWVIEQGLAFYWGTSEWSAREIEEAHHVAELYGLHAPVAEQCMHNLLDRERAEGEFDPLYKKYNLGTTVFSGLAGGILTGKYNDGIPEGSRYDLNSDDEYIKSRVEFLQSEEGKRQITAVKELSKIAETELNCKVSHLALAWLAKNPNTSTVILGASSPEQVLDNLKALEIIPKLTPGILEKIETIVNNKPGPPSTYGRPDLDVHGRRWFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4KM84</accession>
    <name>W4KM84_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_153621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540783.1">
        <property type="nucleotide sequence ID" value="XM_009542488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KM84"/>
    <dbReference type="STRING" id="747525.W4KM84"/>
    <dbReference type="GeneID" id="20667442"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_153621"/>
    <dbReference type="eggNOG" id="ENOG502S6PS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010595_5_2_1"/>
    <dbReference type="InParanoid" id="W4KM84"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="36606" checksum="4D37D3E04A69235E" modified="2014-03-19" version="1">MRSASPAPSQYSVTSSIRAQSYRLEFGRGLNNYSDVYQLPADDEELERLDMQHVMFKVVMGKYPPPLVEILSEVIPGEPKACLDLGCGSGSWIMDVARDFPNCQAVAVDLVPMQAEDMPPNCRSEVDDINLGMQHFYGDFDVVHTRLVSSGVRDYRAFIDEIARVLRPKGLVEIVEFDFRCYDNDHKPILSIPDAMEPPWLPRWFNLSNMAVRQRGGTPDASNMLYAWFRQHPAFEDIVYREVWLPTSAFYQKGHKDFYAGTVMQKDIQAFLKSGRPLLLGSGLPEAYVDEVTQLAHDEVEAAQTVTFCRVESVYARKREAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KN25</accession>
    <name>W4KN25_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_406876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541055.1">
        <property type="nucleotide sequence ID" value="XM_009542760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KN25"/>
    <dbReference type="GeneID" id="20672550"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_406876"/>
    <dbReference type="HOGENOM" id="CLU_2849955_0_0_1"/>
    <dbReference type="InParanoid" id="W4KN25"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW87114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="65" mass="6683" checksum="A8F953461C7A1670" modified="2014-03-19" version="1">MISIEKMEKGGGKGAVNDAAIAQPGEGRVHMGRCALGDGAKGAGEVLVRRKEVDGRRFPAFGNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4KN99</accession>
    <name>W4KN99_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Non-catalytic module family EXPN protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_145414</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541212.1">
        <property type="nucleotide sequence ID" value="XM_009542917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KN99"/>
    <dbReference type="STRING" id="747525.W4KN99"/>
    <dbReference type="GeneID" id="20667080"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_145414"/>
    <dbReference type="eggNOG" id="ENOG502S6X4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047639_2_2_1"/>
    <dbReference type="InParanoid" id="W4KN99"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845523" evidence="3">
        <location>
            <begin position="20"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="RlpA-like protein double-psi beta-barrel" evidence="4">
        <location>
            <begin position="105"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW87293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="208" mass="21131" checksum="BAAF9AE1DF07BA34" modified="2014-03-19" version="1">MRFFSSTLVVASLAVSALAVAHSSVSGHVHARRCSRRASTSAVASPASSSAAASSAQPVASSSAIHTSSSHSAPAATSSSPAAATPTAVSDSTTGSESYLSGTQTGQGTYYGTGLGACGITNTDTDYIAAVSKLLFDTYPGYAGVNPNNNPVCGKKIKANYQGKSVTITVTDRCEACKITDLDFSPTAFSQIADQSIGRISGMTWNWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNS3</accession>
    <name>W4KNS3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_456627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540699.1">
        <property type="nucleotide sequence ID" value="XM_009542404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNS3"/>
    <dbReference type="STRING" id="747525.W4KNS3"/>
    <dbReference type="GeneID" id="20676765"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_456627"/>
    <dbReference type="eggNOG" id="ENOG502QT17">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023620_1_1_1"/>
    <dbReference type="InParanoid" id="W4KNS3"/>
    <dbReference type="OrthoDB" id="5595695at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="121"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW86701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="578" mass="61848" checksum="0BD3EB0F6F466138" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPM3</accession>
    <name>W4KPM3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase family 8 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_166861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541239.1">
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:glycosyltransferase activity"/>
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        <property type="entry name" value="GT8_Glycogenin"/>
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    </dbReference>
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        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
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        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW87325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="314" mass="35597" checksum="F336EF21DCCA6375" modified="2014-03-19" version="1">MSRNAAYVTLLTRENYLPGALVVDHCLKAVHSKYPFVVMITPELSQPARDVLTKRGITVREIQSLQPSSGSHTLATHDARFADTWTKLRGFELVEYDRIVLMDSDMIVLRNMDELMELDLPQDSIAAAHACACNPRKLAHYPADWVPANCAYTPLVHPTAIANPTEITPSSPRPYNLLNSGLVVLNPSKELSASIIDYLHTSPLVPTFSFPDQDLLAAFFHGKWRPLPWVYNALKTLRIIHKPLWRDEEIRCLHYILHDKPWHERIGEVGTGGEYEEVHRWWWDRFDTLLAELGESDPDGRNLVAANVAPILPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPT8</accession>
    <name>W4KPT8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_431365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009543405.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="20674530"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_431365"/>
    <dbReference type="eggNOG" id="KOG1102">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="TBC domain-containing protein C1778.09"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
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    </dbReference>
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        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TBC"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="433"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW87843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="708" mass="78793" checksum="B0FC0CCF8C1614E4" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMA3</accession>
    <name>W4JMA3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_430967</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553176.1">
        <property type="nucleotide sequence ID" value="XM_009554881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JMA3"/>
    <dbReference type="FunCoup" id="W4JMA3">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JMA3"/>
    <dbReference type="GeneID" id="20674496"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_430967"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017390_2_0_1"/>
    <dbReference type="InParanoid" id="W4JMA3"/>
    <dbReference type="OrthoDB" id="6407164at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12521">
        <property type="entry name" value="RRM3_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000120">
        <property type="entry name" value="Negative regulator of differentiation 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000400">
        <property type="entry name" value="Negative regulator of differentiation 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF8">
        <property type="entry name" value="RNA-BINDING PROTEIN MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="202"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="293"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="428"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="519"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="590"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="605"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW74682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="662" mass="70499" checksum="F77D50296B17E532" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4JN99</accession>
    <name>W4JN99_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Expressed putative fatty acid biosynthesis enzyme</fullName>
            <ecNumber evidence="6">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">acs1</name>
        <name evidence="6" type="ORF">HETIRDRAFT_442781</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="6"/>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553412.1">
        <property type="nucleotide sequence ID" value="XM_009555117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JN99"/>
    <dbReference type="FunCoup" id="W4JN99">
        <property type="interactions" value="328"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JN99"/>
    <dbReference type="GeneID" id="20675486"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_442781"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_2_1"/>
    <dbReference type="InParanoid" id="W4JN99"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="5">
        <location>
            <begin position="463"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW74954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="570" mass="62157" checksum="C92D8B5D749BDF97" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNA0</accession>
    <name>W4JNA0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_331801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW75037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553486.1">
        <property type="nucleotide sequence ID" value="XM_009555191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNA0"/>
    <dbReference type="GeneID" id="20671682"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_331801"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3074227_0_0_1"/>
    <dbReference type="InParanoid" id="W4JNA0"/>
    <dbReference type="OrthoDB" id="1747567at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="53" mass="6364" checksum="104FD85519D988CF" modified="2014-03-19" version="1" fragment="single">EMEQLDVKTTFLHGGLKEKIWIKQMKGFAKPSKKDQICFLYKRIYNLKESMQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNS8</accession>
    <name>W4JNS8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phytase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_455824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552589.1">
        <property type="nucleotide sequence ID" value="XM_009554294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNS8"/>
    <dbReference type="GeneID" id="20676671"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_455824"/>
    <dbReference type="eggNOG" id="ENOG502QPYR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026803_0_0_1"/>
    <dbReference type="InParanoid" id="W4JNS8"/>
    <dbReference type="OrthoDB" id="425936at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027372">
        <property type="entry name" value="Phytase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37957">
        <property type="entry name" value="BLR7070 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37957:SF1">
        <property type="entry name" value="PHYTASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13449">
        <property type="entry name" value="Phytase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phytase-like" evidence="1">
        <location>
            <begin position="151"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="490" mass="51551" checksum="C7BD17B440E4F9C9" modified="2014-03-19" version="1">MKELASGDMHNMRPSLSGAAAAGTNGLVAFGLIPSNATESTGDTIGGIGSAIALAEFVRLGNGSYSGTLVVQPDRGFNVDGTIDYQGRQHRISFTLTPYYSSTPLSFSAAQRTLALLYRDTLLYVERDDKTTTGLDALGVRAAQTGFPEVADADPVVPIAGSGGGGGDPDRLSLDLEGLVLNGDSSFWVSDEYGPYIYRFDAQGGLLQAIQPPDAIVPLVDGELNFTSVDDPDTGRAGNQGFEGLTTDSAGATLYALLQSATIQDGGNKKKNARHARLLAYNISDPSQFRPSLVGEWVVPLPLDTDNKTLGASELHFVSPGVFLVLARDGGGHGGDDTLSAYKQADLIDISGATDIHGTKFDDPANPVSPKGKLDSAVVPANYVGFVSLINATQLARFGLHNGDPADQALIDAKWESLALAPVGDPQYPDDYFLFTAADNDFISTHGIALGVPFDAGLDNDNQMLVFRVTLPSAVPGDIEDELLTPVWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4JP43</accession>
    <name>W4JP43_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_108456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553315.1">
        <property type="nucleotide sequence ID" value="XM_009555020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JP43"/>
    <dbReference type="GeneID" id="20666351"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_108456"/>
    <dbReference type="eggNOG" id="ENOG502SMS0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065000_1_0_1"/>
    <dbReference type="InParanoid" id="W4JP43"/>
    <dbReference type="OrthoDB" id="2653987at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW74840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="32393" checksum="41159FDDD5E1AC07" modified="2014-03-19" version="1">MAQVVISQASQVIGADLSQSAPTTSFTRPRLNDDMGQLSLGQQESLTQMRNRTQKDQDKEDEAARRKALKELLQSWMDRLQLISVLTTFFAAMEAQLLGNTSPTGSGPVSITAQVANTGLICALIVHSFAAMISFLAAFALIRFKLTEATKEEFRAENFSVASPNSVKLETTTSDQTPSLVNLPPSQTDYRQENHAFHPRPIDRSTSIPEHIRAFIPPPRVFSTNPHIESFNSFHMRKPPMALLEHAYALSISMAAVGFVLVVVGIVCWAWSQLPVSVAIASTAAVGICTVAGAAILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4JP55</accession>
    <name>W4JP55_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_437093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552739.1">
        <property type="nucleotide sequence ID" value="XM_009554444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JP55"/>
    <dbReference type="GeneID" id="20674930"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_437093"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_6_10_1"/>
    <dbReference type="InParanoid" id="W4JP55"/>
    <dbReference type="OrthoDB" id="3269932at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="234"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW75308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="741" mass="83440" checksum="28B577E5D6CD751D" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPG3</accession>
    <name>W4JPG3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_431144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553432.1">
        <property type="nucleotide sequence ID" value="XM_009555137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPG3"/>
    <dbReference type="GeneID" id="20674513"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_431144"/>
    <dbReference type="HOGENOM" id="CLU_769575_0_0_1"/>
    <dbReference type="InParanoid" id="W4JPG3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW74975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="360" mass="41928" checksum="42A25A7630DD88E6" modified="2014-03-19" version="1">MLKHHLEDIQRATSKSLDLDNLQNAAMSVQQVFNTYYARARDVSDNIKYQRRDPEKELRLFASGLYQNALKQYNDIFTPAVLQSLDSVGIPTVAVQQALGQRSGFLDEGDSNYMRRYTFCAFKADGHIMIFESAGKDEKGRRFALDGECMAIDEESPPVTFTERSEDGPIRLFDGRPDALTGILSGTRHIEDTEYASSRKFHLKRLGASTVHRRSALLEVEDTKTRWHIACDAILIQRRRKFSWIYFCARAETRKRLIYLRMRLQCGDDAVKADIERIERFLEPQDQIFYQSLFNEAWDLAPDHSTRSRRQTRVFGRLNVFWLLERISDSREGPPSGFFDHQLQRLLKENRLQSKEAMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPJ7</accession>
    <name>W4JPJ7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_332204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW75015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553467.1">
        <property type="nucleotide sequence ID" value="XM_009555172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPJ7"/>
    <dbReference type="GeneID" id="20671713"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_332204"/>
    <dbReference type="HOGENOM" id="CLU_163763_1_0_1"/>
    <dbReference type="InParanoid" id="W4JPJ7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="61" mass="6541" checksum="448E6B970FF2006B" modified="2014-03-19" version="1" fragment="single">TDPSAAERPSVACRRSGRDRPCLVIAGVFSTCLALLGVSPKLPECLPRTLARVHAYQQAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQV2</accession>
    <name>W4JQV2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_38044</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551848.1">
        <property type="nucleotide sequence ID" value="XM_009553553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQV2"/>
    <dbReference type="STRING" id="747525.W4JQV2"/>
    <dbReference type="GeneID" id="20672024"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_38044"/>
    <dbReference type="eggNOG" id="KOG1960">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040265_1_0_1"/>
    <dbReference type="InParanoid" id="W4JQV2"/>
    <dbReference type="OrthoDB" id="397265at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22385">
        <property type="entry name" value="KH-I_KHDC4_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22386">
        <property type="entry name" value="KH-I_KHDC4_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000037">
        <property type="entry name" value="KH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047890">
        <property type="entry name" value="KHDC4_KH-I_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047889">
        <property type="entry name" value="KHDC4_KH-I_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031121">
        <property type="entry name" value="RIK/BLOM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744">
        <property type="entry name" value="BLOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744:SF0">
        <property type="entry name" value="KH HOMOLOGY DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent RNA helicase PRP5/DDX46/KHDC4 KH" evidence="3">
        <location>
            <begin position="71"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="KHDC4/BBP-like KH-domain type I" evidence="2">
        <location>
            <begin position="178"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW75839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="41770" checksum="8B3024543A2C2FE5" modified="2014-03-19" version="1">MSSKRKWADAPEDGESPAKVAKVEEGKSPSNPAAAAAAIAAKIAAQFSAGTTSNGGSTPGQKDPFDAEFTHDIDINDVRNRYMLTKGSTQTQIHEETGASISTKGVWYPDRAKATEKDPPLYLHIAATTKEILQKAVDKVNELISIDMGSLVDDKKDGRRERRKWPEEKIPVGLESIRNFNVRAKVVGPTGMFVKYIQQETGTRVQIKGLGSGFVDQETGRESDEPMHIHITRGQVARAKVLTDDLLEVVRDEHAKVKAVIHQQQMELHQAQAQYAAYSAFAVCIGYVPPPPSGAPPPPPPGDQPPPPPPDGGVPPAPPMGGATPSAAGPPAATDTDAFAAYWAAYGYDVNSPQFKEWQASQSQYAQYYAQGYGGQEGAPPPSEPAPPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRF4</accession>
    <name>W4JRF4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mis12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_446644</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mis12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551930.1">
        <property type="nucleotide sequence ID" value="XM_009553635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRF4"/>
    <dbReference type="STRING" id="747525.W4JRF4"/>
    <dbReference type="GeneID" id="20675702"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_446644"/>
    <dbReference type="eggNOG" id="ENOG502S72R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082311_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRF4"/>
    <dbReference type="OrthoDB" id="1884855at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008685">
        <property type="entry name" value="Centromere_Mis12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527:SF2">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05859">
        <property type="entry name" value="Mis12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW75665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="33486" checksum="38468F1962E897FE" modified="2014-03-19" version="1">MEATTSTSTITKDSPPAIAAPSVPSVLLPELLSFSPHFLLDDIVNSANDVVGRAVDAIETFLLRWVEDQPPGGAWENTTELEQGLVSFQTLLEFHTDIAFDFFEAWSLRNIFKVPEELEIVVPHQEGLDLDAAQGEKGKQTEDELMDEIEELRKQVDNQHRLKRLYTRAVHKSSIQAARAQRHLQQLSFLQSLVASPSQPLSTLPPHISELFNVIQHLPALDLSRAEVPPSDPAKRQWETGKAGYMSWAISQLIERARSMDAEGSDKETEGGVMASTLVEEANAIGRPEDLKDALGFVLGSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRF7</accession>
    <name>W4JRF7_HETIT</name>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_66497</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551895.1">
        <property type="nucleotide sequence ID" value="XM_009553600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRF7"/>
    <dbReference type="FunCoup" id="W4JRF7">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="GeneID" id="20678782"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_66497"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_0_3_1"/>
    <dbReference type="InParanoid" id="W4JRF7"/>
    <dbReference type="OrthoDB" id="4476201at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF6">
        <property type="entry name" value="GABA-SPECIFIC PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW76157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="534" mass="57170" checksum="67479C97C9FA2685" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRR6</accession>
    <name>W4JRR6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase family 17 protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
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            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009553604.1"/>
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    <dbReference type="AlphaFoldDB" id="W4JRR6"/>
    <dbReference type="GeneID" id="20678786"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_66564"/>
    <dbReference type="eggNOG" id="ENOG502QPVW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038606_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRR6"/>
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    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003830">
        <property type="term" value="F:beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006813">
        <property type="entry name" value="Glyco_trans_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12224:SF0">
        <property type="entry name" value="BETA-1,4-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12224">
        <property type="entry name" value="BETA-1,4-MANNOSYL-GLYCOPROTEIN BETA-1,4-N-ACETYLGLUCOSAMINYL-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04724">
        <property type="entry name" value="Glyco_transf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="358" mass="41235" checksum="6F0C92ECC31C594A" modified="2014-03-19" version="1">MFRSRRLVIATVTILVLILLLVSLDYRFRLYHALSYASRPLWDKPDGPATILPHYYTEGLAIDEHACKLHGWTSRMQQPEMWDAVIVSSEMDLLEIRMNELDSVVDKFFIVESNRTFSGLPKPLSFALNRHKFAAFEHKIVYELFAGGKPGDDAWTIEADHRNTMTRLIRDTYSSAQMRIPPLVISADVDEIPSRHTLQLLKRCQAPNPIHLQMRSYSYSFEWPVGRTSWRPSVQLWEEPTAYYRHSQSSDVALADSGWHCTFCFRHLDEFIQKMKGFSHYDRVGGDESLVDPSNIQQRICEGKDVFGMLPEAFSYKDLLAWAQPDPSKTGIGLPLYLLQHPARYPFLLPGGCVRHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRY7</accession>
    <name>W4JRY7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_105815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551236.1">
        <property type="nucleotide sequence ID" value="XM_009552941.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="156" mass="17072" checksum="6F4A029A7D5AB979" modified="2014-03-19" version="1">MSVHIQESRVCPYPESVHIQIRAQVRIHNSSPFPSLSPALLVPRRDVKPRHARKKEHRLDARETPSPALPPTMQNPPQRPLRTRASTRSRAANCPRPSPTTPPTYPASRNQRPPQLTTPLPPSAPATSADTTPRPATRLEDKPKAGTGDGSAHGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4JS62</accession>
    <name>W4JS62_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_330377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551982.1">
        <property type="nucleotide sequence ID" value="XM_009553687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JS62"/>
    <dbReference type="GeneID" id="20671575"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_330377"/>
    <dbReference type="eggNOG" id="ENOG502SE22">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120123_0_0_1"/>
    <dbReference type="InParanoid" id="W4JS62"/>
    <dbReference type="OrthoDB" id="2430343at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140580">
        <property type="term" value="F:mitochondrion autophagosome adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013898">
        <property type="entry name" value="Atg43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699:SF1">
        <property type="entry name" value="MITOPHAGY RECEPTOR ATG43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="185" mass="20597" checksum="B9710B7F62C211EF" modified="2014-03-19" version="1">MAAEYPRPDYITTLALSQSRADHLRQPVPHKHESLQHARLPVSVIPDLRFEQTYLKRVKPYVHVERRKRTSKGANGENKEETGEGEEEEEIGEAEVITVEWGKVLWITTRDQVISPLLQGALWGAAAIFIRPAVGSLGARVRQWWPTYKEPPPGHEGKGVGFLRSWAKSLFGGAGTAFAGIASVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSD4</accession>
    <name>W4JSD4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Stress-induced hydrophobic peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_106638</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552245.1">
        <property type="nucleotide sequence ID" value="XM_009553950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSD4"/>
    <dbReference type="STRING" id="747525.W4JSD4"/>
    <dbReference type="GeneID" id="20666179"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_106638"/>
    <dbReference type="eggNOG" id="KOG1773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2038375_0_0_1"/>
    <dbReference type="InParanoid" id="W4JSD4"/>
    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF112">
        <property type="entry name" value="PROTEIN SNA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW76020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="121" mass="13547" checksum="2D9430189EBF374D" modified="2014-03-19" version="1">MPRERKVARWKEHRTEADDVTAVNITAVQSPPPTTFAHGSIPFSSSPQSKRRSRTNKMPSQVSSTSDVILYFLAIFIPPIPVFMKRACGADLLINILLWILGWIPGVLHAWYIISKSEGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSY5</accession>
    <name>W4JSY5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_430558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552423.1">
        <property type="nucleotide sequence ID" value="XM_009554128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSY5"/>
    <dbReference type="STRING" id="747525.W4JSY5"/>
    <dbReference type="GeneID" id="20674459"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_430558"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001324_5_4_1"/>
    <dbReference type="InParanoid" id="W4JSY5"/>
    <dbReference type="OrthoDB" id="2272314at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="746" mass="85020" checksum="72E9E7E869FE3069" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4JT15</accession>
    <name>W4JT15_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphoribosylglycinamide formyltransferase 1</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_330002</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552448.1">
        <property type="nucleotide sequence ID" value="XM_009554153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JT15"/>
    <dbReference type="FunCoup" id="W4JT15">
        <property type="interactions" value="306"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JT15"/>
    <dbReference type="GeneID" id="20671538"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_330002"/>
    <dbReference type="eggNOG" id="KOG3076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038395_0_1_1"/>
    <dbReference type="InParanoid" id="W4JT15"/>
    <dbReference type="OrthoDB" id="5575075at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369:SF2">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="5">
        <location>
            <begin position="135"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW76245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="228" mass="24410" checksum="C6EF256C41150546" modified="2014-03-19" version="1">MATESPERRIVVLISGSGTNLQALIDAQNTPALPNTRIVLVLSNRKAAGGLARAASASPPIPTAHLALQPYLKAHPDHSRADYDAEVARIVLRAQPDAVVLAGWMHIMGDGFLDALSGARALDGAPRVDPARAIAVINLHPALPGAFDGAHAIERAYEAFRRGEVAASGAMVHRVVRAVDRGAPVVVREVPFEEGETMEAFEARLHRVEWEIIVEGTRKVLDEVKPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTA0</accession>
    <name>W4JTA0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_37752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551150.1">
        <property type="nucleotide sequence ID" value="XM_009552855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTA0"/>
    <dbReference type="STRING" id="747525.W4JTA0"/>
    <dbReference type="GeneID" id="20671881"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_37752"/>
    <dbReference type="eggNOG" id="ENOG502RZ1N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025462_0_2_1"/>
    <dbReference type="InParanoid" id="W4JTA0"/>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="445" mass="50845" checksum="F6C8D54ADE25C0DE" modified="2014-03-19" version="1" fragment="single">MDAHWLGNHLTGIVLCAGATVLLVHYSRKIWLLNKAAPASEKSNNNENELAVSFVFPNFDPCKESVENIKPVPYRPFRWGTYHVTMGIRNISWDSWIEMDNQFADYHRLRAHRMKKRGERVVQTLPESPNVPTSGFDAARELVHELAEYLSRRYPQTFRVERHSPEKKPGSGWYGEAPIRTITILPPINATYNLDEEDPMTVAGLLVQDDLALMIKGNDDVYYMRSGAICTAGFWRLEDKIGLSLDDIHYHGNVPQYEQKLKTSLNRFLQRLPVDKLIQRNNYFFKIVADPAHPHEPLDPHELGWAESTVGDEDAFEPGSGLGLLNELPPSLSSDVAYEQSESTVKPSMMRLRMERQTLRRLPKTGAIIFTIRTYVVPVEELVKEVGVPGRMASAIRSWPDDVAGYKSRSSYAHHVLPYFDECHRRQVEEGLLKADDQPQTDYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTN9</accession>
    <name>W4JTN9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_143769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551674.1">
        <property type="nucleotide sequence ID" value="XM_009553379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTN9"/>
    <dbReference type="GeneID" id="20667036"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_143769"/>
    <dbReference type="HOGENOM" id="CLU_2831491_0_0_1"/>
    <dbReference type="InParanoid" id="W4JTN9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="66" mass="7442" checksum="1C239E2AEB3DEDEB" modified="2014-03-19" version="1">MVGLDNEQATEQQVGKHPLPSPHTLQTSIPPNTSRLDLESWAIYPPELNCLQGLEVDETRVDGRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTT4</accession>
    <name>W4JTT4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase family 31 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_174998</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551816.1">
        <property type="nucleotide sequence ID" value="XM_009553521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTT4"/>
    <dbReference type="STRING" id="747525.W4JTT4"/>
    <dbReference type="GeneID" id="20668548"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_174998"/>
    <dbReference type="eggNOG" id="KOG1065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087034_0_0_1"/>
    <dbReference type="InParanoid" id="W4JTT4"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF133">
        <property type="entry name" value="P-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="3">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="4">
        <location>
            <begin position="102"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW76958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="295" mass="31540" checksum="C639C82A8BD4D4C9" modified="2014-03-19" version="1">MAHSIAGVLQFQLFQIPMVGDTCGFMCIRGAVGNTDKELCNRCMQLSAFTPFYRNHNQRGALSQGPYGWDSVASASKTAISIRYALLPYWYTLFANASTNCTPPVRALFFEFPDEPELFAVDRQFMVGSDILVTPVLEPNVSTVDGIFLGRGQITWRDWYTHTAVNATVGAPTTLSAPLGHVNVHIRAGAALLTHAQPAYTTSETRAGPYALLVALGVDVAAYGTAYLDDGTSLPLPDSPIANRTVRFIVHAGALTIESTGTFRVEQPLARVTVLGVPSAPGSVFVGGQEAARGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JU70</accession>
    <name>W4JU70_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_118867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551521.1">
        <property type="nucleotide sequence ID" value="XM_009553226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JU70"/>
    <dbReference type="GeneID" id="20666614"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_118867"/>
    <dbReference type="HOGENOM" id="CLU_1938443_0_0_1"/>
    <dbReference type="InParanoid" id="W4JU70"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="130" mass="14181" checksum="575883CD0BB837FD" modified="2014-03-19" version="1">MLARVSALSVFSVLALAIAGLPVLLLGPQGSAARLSTILRQSQLAARTILPLAAAPAYVSVAPRRSLMRAKAALRRAARVKPYDVCKRSASSVNQKYWRAEHIWEYDTATNINKTHGQAWPVRSEFRGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUJ9</accession>
    <name>W4JUJ9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_147950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550759.1">
        <property type="nucleotide sequence ID" value="XM_009552464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUJ9"/>
    <dbReference type="GeneID" id="20667243"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_147950"/>
    <dbReference type="HOGENOM" id="CLU_1168279_0_0_1"/>
    <dbReference type="InParanoid" id="W4JUJ9"/>
    <dbReference type="OrthoDB" id="3263639at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW77222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="238" mass="28696" checksum="84C92E613D53D0C4" modified="2014-03-19" version="1" fragment="single">MRTQGYKDWMRFPKTPNMPERGDGPRCKVLLDSNGPWTRVLIMSVHESIDGHVETEEYVCLMPRCYAIPLMMINKAVAFYESLRQPNGFAIDFPAKEKGLSLTWRNMREYTYIWRLRHAFLDAIYAANHQEVLDENWRWKKIHGYLYREYSKYGHTRSQRRLYRDDEKAKGRTPYTVPDVSEMNWKAALDEDRKRKRWRSFLWRHVSQGYDSFGEENVRLWLEWPKSKCFSVGDDLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUR7</accession>
    <name>W4JUR7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">6-phosphogluconate dehydrogenase C-terminal domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_181199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009552515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUR7"/>
    <dbReference type="FunCoup" id="W4JUR7">
        <property type="interactions" value="254"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JUR7"/>
    <dbReference type="GeneID" id="20668591"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_181199"/>
    <dbReference type="eggNOG" id="ENOG502QWBM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031468_2_1_1"/>
    <dbReference type="InParanoid" id="W4JUR7"/>
    <dbReference type="OrthoDB" id="3609at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF43">
        <property type="entry name" value="KETOPANTOATE REDUCTASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="1">
        <location>
            <begin position="56"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="2">
        <location>
            <begin position="320"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW77283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="46163" checksum="48F0A8DBE055F460" modified="2014-03-19" version="1">MLGDTYADEMKFVPRRHPRALSRRNHALPPVFVLVAAFTCKIPNDSRAMSPPPKDVLLVGYGAVGAIYSLILKNSGRARVTAVARSNYAAVSAHGMEFRSKKYGDIVGWRPDRVCASVADASDRAYDYVVVTTKAIPELARTPALLAPLLAPAYARAHAQPTYVLFQNGLNVERDLHAAVAALGRAPRIISTAVYISTAMLGANVVRHETFDRVSLGVYRLDDYTTATNSEGEQALLDDFAGLLEDGGSTVTVVPEIQRVKYAKNFWNVAFSSIGALTRHSPAAIFSLPTTAAAPTSPPSDTPALARIPPSVSQAPLITQHTLPAIRALMHELLALGRALGFPDDADGGLPAGFPDALIESTRELHLAPGAAHRPSMLVDLDNGRPIEVEVILGEVVRMARARGVDVPRVEMLYAMLLVVQNQLLQSSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVU7</accession>
    <name>W4JVU7_HETIT</name>
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        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_460536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550738.1">
        <property type="nucleotide sequence ID" value="XM_009552443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JVU7"/>
    <dbReference type="STRING" id="747525.W4JVU7"/>
    <dbReference type="GeneID" id="20677084"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_460536"/>
    <dbReference type="eggNOG" id="ENOG502SA0T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_723736_0_0_1"/>
    <dbReference type="InParanoid" id="W4JVU7"/>
    <dbReference type="OrthoDB" id="2123378at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="279"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW77200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="382" mass="44538" checksum="F64373EE554652FA" modified="2014-03-19" version="1">MDALRAKTRWLHRRRSPTIPVARSASETYNPVRDKALPISPHDGQIVRARSEDAYASPQQPRRMASAVQTGLPPLPLDQLMDMHNVNEPPPPTPPKASIDYSEAGGHKRSTSSTRPTNRVILSPTITMSPQERARRRMEAQMRQRREEEEALRQEEARQARLKAEKEELLRRDAEDERRRRAMLERDVQQSVALRRQKEERERQEAEAWARELEERRREEKERRLEHGRRGEALRREEQARLEEAARIEAEARRRTERKRAQAKADARKLRKQKKGSHELILGGWLTVQTDQTPVWKRRYFQLTPSSLKLYKTDEDLSQPLDEIDLDGRVQAVREWHEGFEELEAIPHSFAILLSNGQGSMSMFTNTDDEKDTLMGFLSSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWB5</accession>
    <name>W4JWB5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_118453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550890.1">
        <property type="nucleotide sequence ID" value="XM_009552595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWB5"/>
    <dbReference type="GeneID" id="20666587"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_118453"/>
    <dbReference type="HOGENOM" id="CLU_083072_0_0_1"/>
    <dbReference type="InParanoid" id="W4JWB5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="292" mass="32717" checksum="4CD642BCFF0AAE5E" modified="2014-03-19" version="1">MPSNESTHLFSENTLIEQTSSTDPSIPSTPEMSVVEERSVPWDTDEEQAAREAEEGFSEYLEGLDEDERRQDEMIRLLTEDFDRPSPSHSPSPPPLIREANEGVIFPDRETYLTTPVAYMMGLIEGTPNTEFVSGPTRPEIQRALEILEEERSFVRHAQRALQIREGTIIARINAGERKLMGLQNLRDSFHPADDPTPSTEYHMPTTAVVSRASSTASNGAPLRPMPGTYPTRTDRERGVYRFTPVSPRIHLLPAPPGLIRPSLRTRPPLPFTEYDSSESDTAPVILRPRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWK0</accession>
    <name>W4JWK0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_325999</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
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                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549732.1">
        <property type="nucleotide sequence ID" value="XM_009551437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JX91"/>
    <dbReference type="GeneID" id="20675661"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_445962"/>
    <dbReference type="eggNOG" id="KOG1546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_637873_0_0_1"/>
    <dbReference type="InParanoid" id="W4JX91"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="3">
        <location>
            <begin position="50"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW77695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="430" mass="48184" checksum="E6E2D1D5E374BEDD" modified="2014-03-19" version="1">MAPVTKHGNGAVEACAGEKPDVSVEREVADILQDDRLHAKEDRSSSRRGRRRALLIGIRYEQDEQWDTLDKTHEDVDTFRRLLLDVYGYRAEDMIVMKDDVKASSELVPTQVNIRRKLRWLVSGARSDDRFILLFAGHSTQQDARDDLEEDGQDEVMITSDGERIVDNELKKTLVDPLPPGCSLTSRRKTRTMYESITRRMAALIGKNHSASSSGSVHSRASSHVTAQTRLSIDTQVFISSALPTALEKAPSCSDGLFSLPQSPSSTADRWTSTSDNWPFMAEDPYADIEKKHTSSSKRGSVNSYLGCNGWVLDTARVAACVVPNAMREPPVAIPMLGLVRAVHRALRKHRLTFRVRRQAASMGWSEWVYDAGALPVSHYNMHKLSRALHEWTRNAKKEARQDVNGEMNVFQTPVLSSLVKLNMDDILSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXE6</accession>
    <name>W4JXE6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glycosylphosphatidylinositol anchor biosynthesis protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_240833</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551046.1">
        <property type="nucleotide sequence ID" value="XM_009552751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXE6"/>
    <dbReference type="STRING" id="747525.W4JXE6"/>
    <dbReference type="GeneID" id="20668873"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_240833"/>
    <dbReference type="eggNOG" id="KOG3144">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064564_0_0_1"/>
    <dbReference type="InParanoid" id="W4JXE6"/>
    <dbReference type="OrthoDB" id="17366at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009580">
        <property type="entry name" value="GPI_biosynthesis_protein_Pig-F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06699">
        <property type="entry name" value="PIG-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844142" description="Glycosylphosphatidylinositol anchor biosynthesis protein 11" evidence="9">
        <location>
            <begin position="20"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW77561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="27213" checksum="A25E03E1202EC7D9" modified="2014-03-19" version="1" fragment="single">LHTLVLSASLFLLPQTSLLFPLPPLERGLDRPQHPFLGPITSRPLVTLAWIVTGSALLVGWWSGWVREWVREGGMGGAGVEARLVRKGEGKGTDIRNASLFTLYASVAIHLVLVLFSAPITTHLAHTYLLSLLLSILTTFIPAYCLGPPILPFFLPFITGAESQPGSSAAVVQNDTWIRLFAEFAPRTAPERAFVYPAIGTFLGAWAGVIPIGLDWDRPWQAWPLTPAYAAVIGYSFGALGALGMNILLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXK7</accession>
    <name>W4JXK7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_324865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550201.1">
        <property type="nucleotide sequence ID" value="XM_009551906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXK7"/>
    <dbReference type="GeneID" id="20671090"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_324865"/>
    <dbReference type="HOGENOM" id="CLU_203563_0_0_1"/>
    <dbReference type="InParanoid" id="W4JXK7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="58" mass="6569" checksum="C9933A1EEB53E5B5" modified="2014-03-19" version="1">MGILSGQISRCLELFQVLVICPDLEGMLCTFKVVVPVFQCFYDSQEFPVVDVVIPLCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXS1</accession>
    <name>W4JXS1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_149190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550302.1">
        <property type="nucleotide sequence ID" value="XM_009552007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXS1"/>
    <dbReference type="GeneID" id="20667326"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_149190"/>
    <dbReference type="HOGENOM" id="CLU_2184314_0_0_1"/>
    <dbReference type="InParanoid" id="W4JXS1"/>
    <dbReference type="OrthoDB" id="3299832at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="109" mass="12575" checksum="364F1C561AE77E0B" modified="2014-03-19" version="1">MTDEPVRSTLKGRSTTNMPLNCRRWQLLSSTPPPHDHGCSRYEQKQSSSAFETVSRNMVENERKRNTSRYTELHICDPRDWVAQTQTSVDNHNERGNRVLDIVSVTDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYQ5</accession>
    <name>W4JYQ5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_388317</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550215.1">
        <property type="nucleotide sequence ID" value="XM_009551920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYQ5"/>
    <dbReference type="STRING" id="747525.W4JYQ5"/>
    <dbReference type="GeneID" id="20672363"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_388317"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_23_1"/>
    <dbReference type="InParanoid" id="W4JYQ5"/>
    <dbReference type="OrthoDB" id="17410at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="96"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="131"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="182"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="226"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="275"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="319"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW78225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="355" mass="38734" checksum="CD5609BDA23820D1" modified="2014-03-19" version="1">MSGIDELDPSSIPAEFLKEGPDWVAAFNPRVQRVMDVKLENKFIHDKVVCSVRFSGDTRYLAVGVDNGVSLYDMSTGGTIVLPFDHAGDVPDRDYVRSVSFSHDGRSLAAGCEDKSVRVWDLESKQLAHTLSGHRREVYAVEFSPDGKTIVSGSGDRTLRLWDLTAPSPSESSRTLVVEDDLSKSDTGITALAISPDGDFVASGALDGSVRIWNIKMEEPKAIVRWQAHQQSVYSVRWVLQGKGLITGSLDRTLKRWEIGVVGENGGKNECVKTMVGHRDYVLATATVQEGYMLRAASASRDGTVRLWDLKTGQALFFIQGHTNTVTSVDLSSDGKFLASGSGDGSARIWSYTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZH8</accession>
    <name>W4JZH8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_453490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549236.1">
        <property type="nucleotide sequence ID" value="XM_009550941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZH8"/>
    <dbReference type="STRING" id="747525.W4JZH8"/>
    <dbReference type="GeneID" id="20676389"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_453490"/>
    <dbReference type="eggNOG" id="ENOG502SZ5P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_189312_0_0_1"/>
    <dbReference type="InParanoid" id="W4JZH8"/>
    <dbReference type="OrthoDB" id="3212378at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="77" mass="8531" checksum="FC41AEA068AA9031" modified="2014-03-19" version="1">MNHSHPMSATQAKERHYAQLANSLTRLSRSVGQTADLFEQLQIDLDSMRTLAALHAAQFMSVATRLNPEAAAHEEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZI5</accession>
    <name>W4JZI5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DUF1640-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_441102</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCDC90 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549165.1">
        <property type="nucleotide sequence ID" value="XM_009550870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZI5"/>
    <dbReference type="FunCoup" id="W4JZI5">
        <property type="interactions" value="256"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JZI5"/>
    <dbReference type="GeneID" id="20675325"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_441102"/>
    <dbReference type="eggNOG" id="KOG3156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063283_2_0_1"/>
    <dbReference type="InParanoid" id="W4JZI5"/>
    <dbReference type="OrthoDB" id="889336at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000018">
        <property type="entry name" value="Mitochondrial protein FMP32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF1">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW78874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24775" checksum="4F4B59E15719B8CB" modified="2014-03-19" version="1">MLPRQLRSVVHQRQCWRIPYFPSALRSFSHSSVLNDFHFDTHHFVQRLEREGLNKAQAEGIMSAMAEVIDESIRNMTSNMVTKADQEKNHYTQQVDFAQLKSELQLVEKNDLAMIKAENDRLVTDIEKLKQRLREEITRTQAGVRLDLNLEKGRIREEASRQELKVKEVDTRIEQEIAGLRAAIQSSKATTLQYLVGFVTGCSALLMAYLRFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZU2</accession>
    <name>W4JZU2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major royal jelly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_420181</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major royal jelly protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549277.1">
        <property type="nucleotide sequence ID" value="XM_009550982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZU2"/>
    <dbReference type="GeneID" id="20673634"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_420181"/>
    <dbReference type="eggNOG" id="ENOG502QS0T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031076_0_2_1"/>
    <dbReference type="InParanoid" id="W4JZU2"/>
    <dbReference type="OrthoDB" id="7776143at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF18">
        <property type="entry name" value="PROTEIN YELLOW-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004843997" description="Major royal jelly protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW78999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="45716" checksum="0E8024C3C1433A7E" modified="2014-03-19" version="1">MRAAILLSLSTLLLSVLASGSIRGTFETGALAFNPYGPFQVFGNASIGPELTVEHLFLDQWPTGVGVSSTGKIYATFPTDVNSTNSKFSLGIITSNTTEAAFPSVEVNQPPTGFLSSTDPSHFGSSDSDHLISVQSVVVDALDRVWALDSGRPLLNAQSLLGSEGGPKLVAFDQNGTKLATFVLPVGVAFPDSYLNDVRFDLRTSTLPAGKGVAYIADSSNEGRNGIIVVDLGTGKAWRHLDSVALTRADDNFRSSYDGRPLQPVTPSGIFTRITTGADGIALSNDGEFLYFTPLASRRLYRVPTSLLLVQPGPVHPNAAIAAIAGTQFIGELPSHANGLETDANGLIYISAPEHNAITILHPDTGLLETLVKDPRIQWPDTLSVATNNRLYFTSNQLFLQPSLNNGTDYRVPPFGMFSVPIGAGNVQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0P8</accession>
    <name>W4K0P8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_453795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549601.1">
        <property type="nucleotide sequence ID" value="XM_009551306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0P8"/>
    <dbReference type="GeneID" id="20676424"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_453795"/>
    <dbReference type="HOGENOM" id="CLU_450589_0_0_1"/>
    <dbReference type="InParanoid" id="W4K0P8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="606" mass="66136" checksum="C5AB409DBFD09FF6" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0R2</accession>
    <name>W4K0R2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heme peroxidase 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hpox6</name>
        <name evidence="1" type="ORF">HETIRDRAFT_103881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548005.1">
        <property type="nucleotide sequence ID" value="XM_009549710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0R2"/>
    <dbReference type="GeneID" id="20665946"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_103881"/>
    <dbReference type="HOGENOM" id="CLU_1175554_0_0_1"/>
    <dbReference type="InParanoid" id="W4K0R2"/>
    <dbReference type="OrthoDB" id="544277at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="236" mass="26144" checksum="46AB9C02DD0FBA18" modified="2014-03-19" version="1">MHSNKACVRTANLHGVPALLKVLRRAFINGPMINLEEPLSYNADTPGRPYLEDFQHMVLSAAMYFGGRITVVVIPKLPDDDTTVSKDEIAVSAIWMPSHPNWARPPFDSFAHRASEAIVEIRMDGSPGAPDLAFQRVNLRALCSSLYSAMLGGCPHPASSSDGDVRLPWHVCEPYFYFLIGAQSTIDSFAQFIAFYVAACSSASVPRWPTTELDTPPMSTTFIHHTSRKAWYSRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0V3</accession>
    <name>W4K0V3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_103854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548045.1">
        <property type="nucleotide sequence ID" value="XM_009549750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0V3"/>
    <dbReference type="GeneID" id="20665943"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_103854"/>
    <dbReference type="HOGENOM" id="CLU_2066965_0_0_1"/>
    <dbReference type="InParanoid" id="W4K0V3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="119" mass="12735" checksum="82A7AEE02BA16EB5" modified="2014-03-19" version="1" fragment="single">MGSQVVAGVGVLGIDAVKFNILRQLPGSLRSADSPDARQRPLHSSRSHFRFHAHRRPPVDEIPNKTASDSSTPTMQSPSDDMKAQPRPSSDVPAYPPSSDVPHDTKAPIPPDTVPSPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1Q1</accession>
    <name>W4K1Q1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_48686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547921.1">
        <property type="nucleotide sequence ID" value="XM_009549626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1Q1"/>
    <dbReference type="GeneID" id="20678078"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_48686"/>
    <dbReference type="HOGENOM" id="CLU_2677747_0_0_1"/>
    <dbReference type="InParanoid" id="W4K1Q1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="76" mass="8801" checksum="4203DE4437CCCFC9" modified="2014-03-19" version="1" fragment="single">KSIPPPSVRNDVKLGLVRNDDKLRSVRNDVKLGLVRNDDKLRSVRDDVKLSIHVRKDVKLRIVRNDDKLRTVPHDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2C6</accession>
    <name>W4K2C6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_103833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548083.1">
        <property type="nucleotide sequence ID" value="XM_009549788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2C6"/>
    <dbReference type="GeneID" id="20665939"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_103833"/>
    <dbReference type="eggNOG" id="ENOG502SQ8R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094288_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2C6"/>
    <dbReference type="OrthoDB" id="3133596at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="207" mass="23882" checksum="6EC83E981E1EDC41" modified="2014-03-19" version="1">MSPMSATGAITICSVVFLSRLKWAWGMKYDIIQMDQDSNTIPLRHDWRDLFESDRWALMPSTDIIDKLWDRWVRFDPRDGHVPSIEDIYDGAEIFEYCLVPLFPDVPSISRRNKVEDALKGDEYSGNSVHVNPFDTLPPIFSKIRPHFVVYDAGRKIDSISLQTYRTTSDIARIYGVSQEKAERVTTVVYATYCTWSNHVHPATFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2C9</accession>
    <name>W4K2C9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_171516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548504.1">
        <property type="nucleotide sequence ID" value="XM_009550209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2C9"/>
    <dbReference type="GeneID" id="20668344"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_171516"/>
    <dbReference type="HOGENOM" id="CLU_2359998_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2C9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844265" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10091" checksum="7C0FDA61A9FA75A4" modified="2014-03-19" version="1">MLVGARILVFLQVEVEAFPSCTSSSTSASSSCRTSSHASVAFLSRSSLTSFHTSHFMLAVSVSVSPLHPVSPLFFFPLLPRPHIPCCAPLSAAAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2M1</accession>
    <name>W4K2M1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_419286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548169.1">
        <property type="nucleotide sequence ID" value="XM_009549874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2M1"/>
    <dbReference type="GeneID" id="20673555"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_419286"/>
    <dbReference type="HOGENOM" id="CLU_2961058_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2M1"/>
    <dbReference type="OrthoDB" id="2559662at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="59" mass="6552" checksum="76FE06144506352D" modified="2014-03-19" version="1">MGTDTGTDTQIISYHIISISLSSDPHIRACGIYFSPVDLLSHRHCVSLAVHSVVYLYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2N5</accession>
    <name>W4K2N5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_322215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548519.1">
        <property type="nucleotide sequence ID" value="XM_009550224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2N5"/>
    <dbReference type="STRING" id="747525.W4K2N5"/>
    <dbReference type="GeneID" id="20670826"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_322215"/>
    <dbReference type="eggNOG" id="ENOG502SAR4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022490_1_0_1"/>
    <dbReference type="InParanoid" id="W4K2N5"/>
    <dbReference type="OrthoDB" id="3364069at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW79994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="482" mass="53037" checksum="E40C932E32D7665A" modified="2014-03-19" version="1">MGVGKLIMAAAAWRFGRERSPQNNTENGQSALLGSESQPSRLAAGISRRSYGATEVISGPPGILGRTQSHSPETYCNGALARVPEDRVYEDPDTFDEEEFLGERGIYIGESSQAYFLTIYLRTFAGSYQQLVSWYTLVPVTCILIWLALAFLPRLLWHTPHPSSPTPFPELLLSISLWSLSHLLSTPIFTLSSALFRLPPGPTTIFSTALHVLLRNLLRLAALPILRVRHYMDYPHPNPADPAFWRVWWLALGWSLAEVAVGVAQGYEQIGLYRNALVPAARVHELEALTRAQTKQPRVGSGERGGSSSRAASAHDDSGRGDSTVREPERRPTMQRWPSEAEMVLEVERDLDTLITLKAREELEDMYGIPFIHIPVFVSCLLRIASIALSLGFLLLLSAAYLSAPLSRSSLLFTASSHPPIFTTNGAFYVTFSLVFLLHFSISLLHTPMALPKIGVHVVAYVGFLIGLGSIFAGLGMWGALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2U5</accession>
    <name>W4K2U5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Importin-13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_386605</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548654.1">
        <property type="nucleotide sequence ID" value="XM_009550359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2U5"/>
    <dbReference type="FunCoup" id="W4K2U5">
        <property type="interactions" value="205"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K2U5"/>
    <dbReference type="GeneID" id="20672282"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_386605"/>
    <dbReference type="eggNOG" id="KOG2022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005996_3_0_1"/>
    <dbReference type="InParanoid" id="W4K2U5"/>
    <dbReference type="OrthoDB" id="2016913at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040709">
        <property type="entry name" value="Importin_rep_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040520">
        <property type="entry name" value="Importin_rep_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF33">
        <property type="entry name" value="IMPORTIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18773">
        <property type="entry name" value="Importin_rep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18806">
        <property type="entry name" value="Importin_rep_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="7">
        <location>
            <begin position="121"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW80137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1024" mass="112626" checksum="2429D55D5CF69F20" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3G2</accession>
    <name>W4K3G2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_452933</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
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    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548409.1">
        <property type="nucleotide sequence ID" value="XM_009550114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3G2"/>
    <dbReference type="STRING" id="747525.W4K3G2"/>
    <dbReference type="GeneID" id="20676315"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_452933"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007776_0_0_1"/>
    <dbReference type="InParanoid" id="W4K3G2"/>
    <dbReference type="OrthoDB" id="273181at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF530">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE DDB_G0271350-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="8">
        <location>
            <begin position="201"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="596"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="688"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="106"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="332"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="473"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="772"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="786"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="796"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW79870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="894" mass="95473" checksum="B326662CBDF40F98" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3T8</accession>
    <name>W4K3T8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_453013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548530.1">
        <property type="nucleotide sequence ID" value="XM_009550235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3T8"/>
    <dbReference type="GeneID" id="20676327"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_453013"/>
    <dbReference type="HOGENOM" id="CLU_1012140_0_0_1"/>
    <dbReference type="InParanoid" id="W4K3T8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="275" mass="29704" checksum="9D919090D5337952" modified="2014-03-19" version="1">MSSWHSVACIASTLEAPPFCAAIVDFPLRGRRVYPRLARLAARIRNRPRDPVRPNANMNAPGYVRRPRRHPPLARRSPPPPDTTFLPCAFARDVSGRVGLLWPSLNTVGRHHLHQSRPPRPPPPRASVPCFCPWRVHACMHVRVQLPPLPPPRIDAQRLCAAAAASVCCRRVHALPSASGLRAGSRAVEGLARLLVCERGGRTDGRARALGSRHDSCPGARARVELMGVQQDVAGRRSSVCGSTRDAGRRGANKLEDGGASQGSGPGRSVRPVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4K404</accession>
    <name>W4K404_HETIT</name>
    <protein>
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            <fullName evidence="2">Conserved oligomeric Golgi complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_476235</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547301.1">
        <property type="nucleotide sequence ID" value="XM_009549006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K404"/>
    <dbReference type="STRING" id="747525.W4K404"/>
    <dbReference type="GeneID" id="20677666"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_476235"/>
    <dbReference type="eggNOG" id="KOG2211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009839_0_0_1"/>
    <dbReference type="InParanoid" id="W4K404"/>
    <dbReference type="OrthoDB" id="18786at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019465">
        <property type="entry name" value="Cog5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048485">
        <property type="entry name" value="COG5_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049176">
        <property type="entry name" value="COG5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228:SF3">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20649">
        <property type="entry name" value="COG5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10392">
        <property type="entry name" value="COG5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 N-terminal" evidence="6">
        <location>
            <begin position="12"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW80568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="878" mass="95089" checksum="0C2775F53E750080" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4K448</accession>
    <name>W4K448_HETIT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_171390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="747525.W4K448"/>
    <dbReference type="GeneID" id="20668337"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_171390"/>
    <dbReference type="eggNOG" id="ENOG502T2QY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_417400_0_0_1"/>
    <dbReference type="InParanoid" id="W4K448"/>
    <dbReference type="OrthoDB" id="3266753at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="780" mass="90356" checksum="457350B6A5427CD3" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4C9</accession>
    <name>W4K4C9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_322599</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009550142.1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="eggNOG" id="KOG1781">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_3_1_1"/>
    <dbReference type="InParanoid" id="W4K4C9"/>
    <dbReference type="OrthoDB" id="274944at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017132">
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    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037188">
        <property type="entry name" value="U6_snRNA_Lsm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="7"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW79901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="103" mass="11420" checksum="1ACE77ECFF27010E" modified="2014-03-19" version="1">MDKPKREAILDLSKYVNERIRVKFTGGREVTGVLKGYDQLLNLVLDEVEEAVQGDKAMPNGEVLEPEPHVRTLGLAVLRGPTITLLSPVDGLEEIANPFMVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4F4</accession>
    <name>W4K4F4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_321130</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547434.1">
        <property type="nucleotide sequence ID" value="XM_009549139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4F4"/>
    <dbReference type="FunCoup" id="W4K4F4">
        <property type="interactions" value="367"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K4F4"/>
    <dbReference type="GeneID" id="20670723"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_321130"/>
    <dbReference type="eggNOG" id="KOG1462">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016743_3_0_1"/>
    <dbReference type="InParanoid" id="W4K4F4"/>
    <dbReference type="OrthoDB" id="1733332at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04652">
        <property type="entry name" value="LbH_eIF2B_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="11">
        <location>
            <begin position="47"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="EIF2B subunit epsilon/gamma LbH" evidence="12">
        <location>
            <begin position="404"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="318"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="499"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="521"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW80718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="532" mass="58733" checksum="005E4F985F45CA17" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4U3</accession>
    <name>W4K4U3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_169514</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547477.1">
        <property type="nucleotide sequence ID" value="XM_009549182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4U3"/>
    <dbReference type="GeneID" id="20668222"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_169514"/>
    <dbReference type="eggNOG" id="ENOG502S3G3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_676251_0_0_1"/>
    <dbReference type="InParanoid" id="W4K4U3"/>
    <dbReference type="OrthoDB" id="8955945at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="292"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW80769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="368" mass="41411" checksum="944C3FDAD1BC4E03" modified="2014-03-19" version="1">MLQCLLLFAAESDRYKTDQDKISLVLSCMRYGTAGAWAENFLLRSVGADPPTDLGTWKDFLAKFKLQFRETGKTDKARSALMAFSQGRMTVDEYSNQFILIAADADISEKEQVPYFQRGLDPRVMDKIYDKEVQPKDTIQDWINTACEIDGRLRARTAQKAILANSTSFQSDYLNRFHNQISPRYNSTNAPRRMNNQVVDMDIDATRKRNALSQKRKHDSKPPGACYYCGKTGHWNTDCPSLRRGVRPIRGNSKRRMGTTGRRSRAVDLEGEDDAPVMGDQAGIYRGMETEDVHRNNQRVPQPGPLMERPHSTPSGQPQTNHGQRAMLPNGRRGDGSVSHSARIGAVLGELGEDEAREVILGHAERFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4W8</accession>
    <name>W4K4W8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_418810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547562.1">
        <property type="nucleotide sequence ID" value="XM_009549267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4W8"/>
    <dbReference type="STRING" id="747525.W4K4W8"/>
    <dbReference type="GeneID" id="20673511"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_418810"/>
    <dbReference type="eggNOG" id="ENOG502QRAQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049915_1_1_1"/>
    <dbReference type="InParanoid" id="W4K4W8"/>
    <dbReference type="OrthoDB" id="10267950at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056144">
        <property type="entry name" value="DUF7727"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24853">
        <property type="entry name" value="DUF7727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7727" evidence="3">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="2">
        <location>
            <begin position="309"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW80863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="445" mass="49962" checksum="EA001E389B90A7C7" modified="2014-03-19" version="1">MGNLIWHEYARFVSLTASVYTVWASFFGLIYRKFFWDFVNGTIRAPGGLQPAPQDAFFISIIVKAPIVPIISMILGLMLVALDYPAPFLKGTGIHRSFMLRVVGMIFQAFFAVLWYQVSSFEKAKTAGDLFFFPSEIHRHDDSGIQFEIRLCPALQQKPHLPTPHFSTSQTPEVPLEQRRADPFEPPYAPNLYVGELTDEEEGTEYAVLLNKFSVVPNHFLLVTKKYQSQASPLMPSDLVQAYSILLAARKARTPFFAFYNCGDNSGASQPHKHIQFLPLEDEDGPPIEELARAAKIDKDEKPFSLSVLPFAHHIRRLSIRRSSTPADLEPILASAFLELLDLVISTVRHDESYPAGTPSYNVLLTLEHMYLIPRRQETYVLEESGEKLNINALGFAGMLLVKEDAELEAVKKEGPVKILRGVGCESIHDLQVQGSLELDGDPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4Y7</accession>
    <name>W4K4Y7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_318552</name>
        <name evidence="5" type="ORF">HETIRDRAFT_321111</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546725.1">
        <property type="nucleotide sequence ID" value="XM_009548430.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547570.1">
        <property type="nucleotide sequence ID" value="XM_009549275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4Y7"/>
    <dbReference type="GeneID" id="20670518"/>
    <dbReference type="GeneID" id="20670722"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_318552"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_321111"/>
    <dbReference type="eggNOG" id="ENOG502S3G3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_676251_0_0_1"/>
    <dbReference type="OrthoDB" id="8955945at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="276"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW80872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW82170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="407" mass="45488" checksum="0640FB174E4C0C80" modified="2014-03-19" version="1">MSGQASTSTNTPSATVQPGRGKVKLPDNYTGDRIESQKFMLQCLLLFAAESDRYKTDQDKISLVLSCMRYGTAGAWAENFLLKSVGADPPTDLGTWKDFLAKFKLQFRETGKTDKARSALMAFSQGRMTVDEYSNQFILIAADADISDKEQVPYFQRGLDPRVMDKIYDKEVQPKDTIQDWINTACEIDGRLRARTAQKAILANSTSFRSDYLNRFHNQISPRYNSTNAPRRMNNQVVDMDIDATRKRNALSQKRKYDGKPPSACYHCGKTGHWNTDCPSRRRGVQPTRGNSKRRMGTTGRRNRAVDLEGEDDAPAMGNQAGIYRGMETEDVPRNDQRVPQPGPSMERPHSTSSGRPQTNHGQRAMLPNGRRGDGSVSHSARIGAVLGELGEDEAREVILGHAERFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4K518</accession>
    <name>W4K518_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_123022</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547211.1">
        <property type="nucleotide sequence ID" value="XM_009548916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K518"/>
    <dbReference type="STRING" id="747525.W4K518"/>
    <dbReference type="GeneID" id="20666803"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_123022"/>
    <dbReference type="eggNOG" id="KOG3958">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033559_0_0_1"/>
    <dbReference type="InParanoid" id="W4K518"/>
    <dbReference type="OrthoDB" id="4977at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028133">
        <property type="entry name" value="Dynamitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15346">
        <property type="entry name" value="DYNACTIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04912">
        <property type="entry name" value="Dynamitin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="318"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW80465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="390" mass="43495" checksum="B88879BFE72BF346" modified="2014-03-19" version="1">MSVNKYANLPDIDTAPDIYETEDVFPSSQAKQGDSSDEESGVQTRHTSRGKIIEAPGREELDNSSLIGTDEASRRFKRAERKSRQDRSLYKYPPSRSLSPSPSRQKSLSARLRLLQNELASLENEVSDPSNPLLQKEREESNVDPGELIKGLVDVRARLDKVSQKEGRSRLVQEEEGATTKVKDGDQAKDGVKELAEMDRRVGEVEKLIGSSSTSLDEASPMPTPLLLLLSRLNTQVTVLTQPRHLDNISRRLKLLLSDLDRVSSANQQHRRQSHHNEAAIPPNAAPSALQEQITPILTRLVPSLPHIPHILMRLRTLSALHTSAAEFQSTLEGLEEEQKKAREALEELSRALDSVEGSLDENRKLVEGNVSGLEERVQSLLQRVEQVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5X5</accession>
    <name>W4K5X5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pentatricopeptide repeat-containing protein-mitochondrial domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_384986</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547201.1">
        <property type="nucleotide sequence ID" value="XM_009548906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5X5"/>
    <dbReference type="STRING" id="747525.W4K5X5"/>
    <dbReference type="GeneID" id="20672228"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_384986"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008514_2_0_1"/>
    <dbReference type="InParanoid" id="W4K5X5"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057027">
        <property type="entry name" value="TPR_mt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936:SF1">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN GUN1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936">
        <property type="entry name" value="PPR_LONG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23276">
        <property type="entry name" value="TPR_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="119"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="188"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Pentatricopeptide repeat-containing protein-mitochondrial" evidence="7">
        <location>
            <begin position="296"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="330"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="436"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW80451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="573" mass="64494" checksum="F01AAEE957798AF8" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6V7</accession>
    <name>W4K6V7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_385790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkylbase DNA glycosidase AlkA family.</text>
    </comment>
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        <property type="protein sequence ID" value="ETW81080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009549465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6V7"/>
    <dbReference type="STRING" id="747525.W4K6V7"/>
    <dbReference type="GeneID" id="20672254"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_385790"/>
    <dbReference type="eggNOG" id="KOG1918">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033011_1_0_1"/>
    <dbReference type="InParanoid" id="W4K6V7"/>
    <dbReference type="OrthoDB" id="415889at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032131">
        <property type="term" value="F:alkylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000004">
        <property type="entry name" value="DNA-3-methyladenine glycosylase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051912">
        <property type="entry name" value="Alkylbase_DNA_Glycosylase/TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003:SF5">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="5">
        <location>
            <begin position="185"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="331"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="332"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="413"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW81080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="523" mass="56723" checksum="1F6F1021010923E3" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7D7</accession>
    <name>W4K7D7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_451088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545919.1">
        <property type="nucleotide sequence ID" value="XM_009547624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7D7"/>
    <dbReference type="GeneID" id="20676111"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_451088"/>
    <dbReference type="eggNOG" id="ENOG502SYPU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1461499_0_0_1"/>
    <dbReference type="InParanoid" id="W4K7D7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW81245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="185" mass="20488" checksum="5DB322E4EC40FBEE" modified="2014-03-19" version="1">MPTPTLTAIFLLGAIHSLCGGGVLLRQRPRAHAALRRPKHRNRSSVEEADETQLAAEDKEFFSAHPNEYILYPTWLPGSLKTPARRHAHPSYPSHPLLLSTYSTPRPLARIVHASSAHCLHCPDSRLKRPDPLLDAMGTRERKCSARSTVDPASALVPLGPHARFCLRLISTHTRLLDTPIHSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8A9</accession>
    <name>W4K8A9_HETIT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_317863</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546612.1">
        <property type="nucleotide sequence ID" value="XM_009548317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8A9"/>
    <dbReference type="STRING" id="747525.W4K8A9"/>
    <dbReference type="GeneID" id="20670455"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_317863"/>
    <dbReference type="HOGENOM" id="CLU_005726_10_0_1"/>
    <dbReference type="InParanoid" id="W4K8A9"/>
    <dbReference type="OrthoDB" id="2449121at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="68" mass="7886" checksum="8037276661BDAE2A" modified="2014-03-19" version="1" fragment="single">SLDSCPVEVIRRLFNRSWRFMDAYRMGLTGKAAEWAVRKQKSHRRAGPRTIMSVDAMLHQHNTNASEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8L3</accession>
    <name>W4K8L3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_318781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546686.1">
        <property type="nucleotide sequence ID" value="XM_009548391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8L3"/>
    <dbReference type="GeneID" id="20670536"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_318781"/>
    <dbReference type="HOGENOM" id="CLU_735784_0_0_1"/>
    <dbReference type="InParanoid" id="W4K8L3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="376" mass="40687" checksum="5EF04DB5D5266AE3" modified="2014-03-19" version="1">MYMPPRMQYGASGDQMQTHVPYAPPYYNTALPPYPGAVPMYGMAYRAPFNTIPTAQPFVPAHVPPPPSMIYASHPAPSHDADEPRLPSDNMWYGSPSPAPRAASYTAIAAKEMMVYLDQAAAAQGADHASRLPHLGPTPVARTYTHHIIDALGAPNEARLKDHARNVSTLRPWTPQRLRDLAFCIVWEVVTAPPHVHSSKLASLTCLVGDAFSTAADPESYAEHVRRYALATFRGWWKRDLATSVFRVDPTARRAQTERALNLAIYMGYLYVAGYLSSADLVDAARTLVAGGITHSEQLVALRDLLAQSTAGLSSAPAHEQSTMSAVMRDVAAKGAGLREEQSLRGAPVESAELRTLVDDILSLGRAGLGASFKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8L4</accession>
    <name>W4K8L4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin-binding type-4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_317551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546310.1">
        <property type="nucleotide sequence ID" value="XM_009548015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8L4"/>
    <dbReference type="GeneID" id="20670426"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_317551"/>
    <dbReference type="eggNOG" id="ENOG502SRQE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138681_0_0_1"/>
    <dbReference type="InParanoid" id="W4K8L4"/>
    <dbReference type="OrthoDB" id="3944184at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="16873" checksum="F5BEF69E336B7EC1" modified="2014-03-19" version="1">MLSIPFLTTAAPLAYPTGVIVAPINGTSIMPGEVFDFKYNAHADYCMSSYNYSVWLVTDKPTMFMPSETFMTGHLFGTFQEANYPGTPVPYPSNPPPSQLVMPVLSQPQGGFGSGQSAANATFYLMVWEEWDSCDGALGTKISLSMNNIVYNATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8Q7</accession>
    <name>W4K8Q7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_168830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546761.1">
        <property type="nucleotide sequence ID" value="XM_009548466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8Q7"/>
    <dbReference type="GeneID" id="20668184"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_168830"/>
    <dbReference type="HOGENOM" id="CLU_1825527_0_0_1"/>
    <dbReference type="InParanoid" id="W4K8Q7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="141" mass="14349" checksum="F0CA486C526C98AE" modified="2014-03-19" version="1">MSSSASPSESKISLLSHDSTSSSYDENEKASGTGLRKSFSPFVALRSKYSTDSSSSVTSSSSAPPLLHAQTQSQPPPPLTSASALSSHPTKDYEASFGALASSFGYGGGAPIIVKSKKTQTKSATQTGAAAPSTSNNTPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9V7</accession>
    <name>W4K9V7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_50909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545828.1">
        <property type="nucleotide sequence ID" value="XM_009547533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9V7"/>
    <dbReference type="FunCoup" id="W4K9V7">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K9V7"/>
    <dbReference type="GeneID" id="20678164"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_50909"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028281_0_1_1"/>
    <dbReference type="InParanoid" id="W4K9V7"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="4"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="308" mass="34159" checksum="CB89D6CD08EB2BFF" modified="2014-03-19" version="1" fragment="single">DDEPAFVVLDLPGRGKGAIASRDIKRGELLIREQPLFLVPDRITGSPTDFILSRVRALSPTQSQSFYDLSYVNLPQNLSPEEHAKQLPLAIFQTNAVAAGQGVGLFPRMARLNHACSHAFNSIYSWRDDEGVLVVYALKDIKQSEELLTTYTNTKRPRAERRCFLQQNYDFYCVCACCAQSEAGSWASDRRLGAMAALYARLAEWGNGAIDGWEAIGLVRRIWDVGEEEGYHSERGRLAADAMLVAAAHSDAEAVVRWARLAERWSTYELGADSALAKEARRVALSPGSHEMWGGRERMRVGGPEGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KA58</accession>
    <name>W4KA58_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_316985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546546.1">
        <property type="nucleotide sequence ID" value="XM_009548251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KA58"/>
    <dbReference type="GeneID" id="20670380"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_316985"/>
    <dbReference type="HOGENOM" id="CLU_3087503_0_0_1"/>
    <dbReference type="InParanoid" id="W4KA58"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="52" mass="5880" checksum="30425AADD8A49B7B" modified="2014-03-19" version="1">MGVKLGSDIRNPLAITSATSDSIQEPTIRSMNTYRPRNHRYSSYNARSIQHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAJ7</accession>
    <name>W4KAJ7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_475577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546673.1">
        <property type="nucleotide sequence ID" value="XM_009548378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAJ7"/>
    <dbReference type="GeneID" id="20677636"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_475577"/>
    <dbReference type="eggNOG" id="ENOG502SNUG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035509_2_0_1"/>
    <dbReference type="InParanoid" id="W4KAJ7"/>
    <dbReference type="OrthoDB" id="3242376at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="21"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW82111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="241" mass="27205" checksum="159DCAC913F7BEAA" modified="2014-03-19" version="1">MTSNLRDDILADIVNLYLTECFGLASFVVMMWDHLLTLSDEVTFIWLGRKGLYIYLYFVNRYFIPLSFIVNLYAYFGRSWTQESCNHFVRYEGSMTMIGVYIAAFLMLFRLVALYHGNKYVQVPVFAILFAAIAVNAWLLSRGQGVSQSSSLVHSCTMIFDPSLGPVAACAAILPLVYDTVICVLVIARLVHWRGSRETGNLQSTLMKEGLSYYFFGCSVMLASTFTIVYADPSARNIAMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4KB77</accession>
    <name>W4KB77_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Succinate dehydrogenase cytochrome b560 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_473761</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544968.1">
        <property type="nucleotide sequence ID" value="XM_009546673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KB77"/>
    <dbReference type="FunCoup" id="W4KB77">
        <property type="interactions" value="199"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KB77"/>
    <dbReference type="GeneID" id="20677538"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_473761"/>
    <dbReference type="eggNOG" id="KOG0449">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094691_0_0_1"/>
    <dbReference type="InParanoid" id="W4KB77"/>
    <dbReference type="OrthoDB" id="588261at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01001">
        <property type="entry name" value="SDH_CYT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW82620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="18944" checksum="9349659D6A4A2549" modified="2014-03-19" version="1">MNCTRVGLGSALRRAAFSPKIARNQVALRSTFPKRTVQTQSLLPSASEQILNAQRIKRPSSPHFTIYQPQLTWLGSIANRVTGTGLSVLLYGFSLAYLIAPSTFSTANIVETVQALPESVKIAAKTILAAPFAFHSFNGLRHLAWDSGKLLSLSGAYKSGYAVLGATAIGTIVLVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBH9</accession>
    <name>W4KBH9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein arginine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_417080</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13 14">TC 32-1</strain>
        </source>
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    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
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    </dbReference>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010247_0_0_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005634">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR035247">
        <property type="entry name" value="PRMT5_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738:SF0">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF17285">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1 4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
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    <feature type="domain" description="PRMT5 TIM barrel" evidence="11">
        <location>
            <begin position="45"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 arginine-N-methyltransferase" evidence="10">
        <location>
            <begin position="358"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 oligomerisation" evidence="12">
        <location>
            <begin position="523"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="195"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="500"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="394"/>
            <end position="395"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="475"/>
            <end position="476"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for specifying symmetric addition of methyl groups" evidence="7">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF17285"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17286"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW83084.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="781" mass="87649" checksum="56C1A472CC45476F" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4KC00</accession>
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        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 79 protein</fullName>
        </submittedName>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
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                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0016787">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="GH"/>
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        <property type="entry name" value="GH79_Enzymes"/>
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        <property type="entry name" value="Glyco_hydro_b"/>
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        <property type="entry name" value="BETA-GLUCURONIDASE"/>
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    </dbReference>
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        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
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        <location>
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        </location>
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        <location>
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            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="540"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="3">
        <location>
            <begin position="411"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW83397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="559" mass="60284" checksum="DCA140499B714C80" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCE2</accession>
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        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_450711</name>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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            <taxon>Agaricomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545302.1">
        <property type="nucleotide sequence ID" value="XM_009547007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCE2"/>
    <dbReference type="STRING" id="747525.W4KCE2"/>
    <dbReference type="GeneID" id="20676071"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_450711"/>
    <dbReference type="eggNOG" id="ENOG502SSPH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080230_0_0_1"/>
    <dbReference type="InParanoid" id="W4KCE2"/>
    <dbReference type="OrthoDB" id="3250770at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045328">
        <property type="entry name" value="Kre9/Knh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154:SF1">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844211" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="26"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW83010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="240" mass="25108" checksum="B6CA51BEE81E7E0F" modified="2014-03-19" version="1">MRFLQAIFATLAVGTGFSRASLYTTQPVSGTVFHAGELSKVSWIDNGTSPALAELKPLKLELYGTADTLVGTLGTNIDPTSLFYNITISPSVGPDGSDYYLRFVCEDPPLKFYSAKFTIDGASASPASASSGNANSASSNSSTSQSALDKLQHGTPTAAAASTSYKIYPLVTMITANATTPTQSHPTPAPSSASSLTAPTQSGRTVAQTNSAAGRMDMEKIKFRLVFILWPALMGITMAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCQ6</accession>
    <name>W4KCQ6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_439499</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545150.1">
        <property type="nucleotide sequence ID" value="XM_009546855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCQ6"/>
    <dbReference type="FunCoup" id="W4KCQ6">
        <property type="interactions" value="273"/>
    </dbReference>
    <dbReference type="GeneID" id="20675154"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_439499"/>
    <dbReference type="eggNOG" id="KOG0671">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_5_16_1"/>
    <dbReference type="InParanoid" id="W4KCQ6"/>
    <dbReference type="OrthoDB" id="283111at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14134">
        <property type="entry name" value="PKc_CLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="195"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="126"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW82836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="527" mass="59041" checksum="2E58D0C6D62813BC" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCU7</accession>
    <name>W4KCU7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_439664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545442.1">
        <property type="nucleotide sequence ID" value="XM_009547147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCU7"/>
    <dbReference type="GeneID" id="20675174"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_439664"/>
    <dbReference type="HOGENOM" id="CLU_2133820_0_0_1"/>
    <dbReference type="InParanoid" id="W4KCU7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="113" mass="12998" checksum="B2F64FECA9ABBE5C" modified="2014-03-19" version="1">MCVKRRDRGREAETSTIEGEWSVASCALDRPAKRAKKNQRRSRIVDAAGVSERSRKPSTMYREETERKECQNNKHAQRSKDTSARPAGRRMERERARYGTVEADGWLKKGDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCY3</accession>
    <name>W4KCY3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_426400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545231.1">
        <property type="nucleotide sequence ID" value="XM_009546936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCY3"/>
    <dbReference type="STRING" id="747525.W4KCY3"/>
    <dbReference type="GeneID" id="20674115"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_426400"/>
    <dbReference type="eggNOG" id="ENOG502SR9E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_669135_0_0_1"/>
    <dbReference type="InParanoid" id="W4KCY3"/>
    <dbReference type="OrthoDB" id="3245657at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844218" evidence="3">
        <location>
            <begin position="27"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW82926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="411" mass="43923" checksum="19C54CA3131EE62C" modified="2014-03-19" version="1">MPFLGLPLSAARLCFVLSSFLHFACAAAKLVNVTIDDSGKDPVTGALIQYLPNSTFWHGSAEICNTCAAHPDPAQAFDGTWHDSAFHPTSSNTVTAAYVPFTGTAIYVFCIITHTSSSPDGNTDLQFFIDSQLVGTYRLQPTGSTVYDYNVPVYVNESLPNGLHNLTIQNGRIGGLFSLILLDKIMYRSVSHAPIIGGVVGGLAFILALGGLFNFLRRQRHQPYPRNISNFLADEGPYLSPGPSSRLLSQAPRHRPSLTDPFRIDPTLPDTNAPPPGPSKLPRLPTSTAAPIPSTIPSTIDSGSHHGEDHPTADSTLQSPAVSSSWPSASDMPRPDARSGASPASASTPVASLPSPPRQRPLRVFTRKRPRPHDEVGAAPEGSEAPPAYEDIDHRDSSTRAGQAPSTRNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KD14</accession>
    <name>W4KD14_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_425345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543443.1">
        <property type="nucleotide sequence ID" value="XM_009545148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KD14"/>
    <dbReference type="GeneID" id="20674029"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_425345"/>
    <dbReference type="HOGENOM" id="CLU_1619246_0_0_1"/>
    <dbReference type="InParanoid" id="W4KD14"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844163" evidence="1">
        <location>
            <begin position="19"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="164" mass="17414" checksum="72FAA2ABFF42C784" modified="2014-03-19" version="1">MPAPAVLALLSGIGSVSSNAAGNVAGSAIIDILGAIVLAKTESKVTEQCIKHWLFSNGTSEEAKEKLTNTRGFGLIPKSRQYQQTADNPFQDPTQMPNFLHRAVQKPMVASSQLTHSSGQGRDKHVTWATDTETVQSENQDDIALDIALNNVTASDITSAGLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDK7</accession>
    <name>W4KDK7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_48170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543230.1">
        <property type="nucleotide sequence ID" value="XM_009544935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDK7"/>
    <dbReference type="GeneID" id="20677985"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_48170"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_6_1"/>
    <dbReference type="InParanoid" id="W4KDK7"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF6">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="57"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW83819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="496" mass="55823" checksum="12EE6BD0DF112FE0" modified="2014-03-19" version="1">MSAARDAPFQVDQEKQEPAEIHVSAYQKHQSELDAVFGGPEERKRIERRLLWKLDLRMSILIFIYILNYIDRNNAGAARLRGFEADLHLKGQEFATLLSILYVGYILMQIPSNMFLNWIGKPSIYLPCCMIIWGTISVLTGERITKNFVDALLTRFFLGFVEAAFFPGALFLLSKWYTKSELGVRTAILYCGNIISNAFGSLMASGILDGMDGRLGHAAWRWLFYIEGALTIFFAIIALFVLPDFPTTTRWLTPQERSLALKRMASDFAGIGDQNETETGGHTHGLRLALTDWKVWWLSLAMTSNVVSLSFNAYFPTLSATLGYGRTITLVLCAPPFIVAAAAALLLARHSDKSGERFWHVSISLALGIVGFIIAISTMNTAARYVSLFLMAQSYAGFVCFYTWLSNSFPRPPSKRAVALAFINAFSQMGNIAGSYVWPSMWGPTYRNSYAICIACQSLTIVMLWIFRMHLKALNEKMDQDDESKDIKEKGFRYML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEB9</accession>
    <name>W4KEB9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_313801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543893.1">
        <property type="nucleotide sequence ID" value="XM_009545598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEB9"/>
    <dbReference type="FunCoup" id="W4KEB9">
        <property type="interactions" value="696"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KEB9"/>
    <dbReference type="GeneID" id="20670064"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_313801"/>
    <dbReference type="eggNOG" id="KOG0719">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055868_0_0_1"/>
    <dbReference type="InParanoid" id="W4KEB9"/>
    <dbReference type="OrthoDB" id="110024at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056453">
        <property type="entry name" value="HTH_DNAJC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052594">
        <property type="entry name" value="J_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23302">
        <property type="entry name" value="HTH_DNAJC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="18"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW84197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="355" mass="40126" checksum="DFD098280675AEB4" modified="2014-03-19" version="1">MDDQRDPAALFFGSDSVDLYATLTLSESASSEEIKRAYRKLALIYHPDKHATKGESAKADASLKFQQIGFAYAVLSDEKKRNRYDRTGKTDEGFDLGPGEDGWEAYFEELFDRVTREKLDQMKKEYQGSTEETEDLKKAYLNTDGSIDEIMNHIPHSRHEDEPRFVILISSLITEGVLPTKSAWESSTKDEKRKVIRKKQADKEAEEAEEMARELGLWDEFYGSGKPGTRKGKAKGTGKEKKEDEDEEDEEDHSALQALILKKKKNTDSFIDNLAAKYAELPPRGKGKGKRKAGLEEVEDVAESPKKRRRGAAVHPPDIDDNEFEKLQQKLFGDKPKSSGEGSTKNKKGRIRKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KF39</accession>
    <name>W4KF39_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_47433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543210.1">
        <property type="nucleotide sequence ID" value="XM_009544915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KF39"/>
    <dbReference type="STRING" id="747525.W4KF39"/>
    <dbReference type="GeneID" id="20677560"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_47433"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027583_0_0_1"/>
    <dbReference type="InParanoid" id="W4KF39"/>
    <dbReference type="OrthoDB" id="1908178at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051240">
        <property type="entry name" value="Mito_RNA-Proc/Resp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47933">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47933:SF11">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="281"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW84458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="53028" checksum="135B1BED6A658E7C" modified="2014-03-19" version="1">MSTSHSREEVWNAYYVFSLLPHDPKIPEALSSIPVPHLRRICRLLASGPEPRTRIQFLRLLSVSSALHREGGQVRLWQWNALINLAGQGWRRTRLENFTTAIGLYGDMVHGKAPGTMFFSVDNDALEAREEEGAREDRTGPRARRIKPDIVTHSMLLDIAARTGSQQFMAQAAGMLEQSGLRPNVVSHTSMLGYFTRKRDLAGVRATLLKMRQQGIELNVVALNACIWAYAYNGRMDIAEGIYRVMRHRVYGEEREESLDAVIEYLEQRESIVISSRIVPDKITYHTLMQGYAYHGDLVRCLRVFSEMLSTPNLEAAANRYGRRPREPYTATVSAFRSIFLGFSRHARSPLPTTPVSPQLARLPRYQVYPTLDPGAWSLENFDQLFDSFLELPESVRVQEHLMWWVVMGCGRVSGNDAAKMVSVIERMERRYGKVRGTRLTELCADIYRAGCGDGDGGDTLNNTSDGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFA2</accession>
    <name>W4KFA2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuole protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_237589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544074.1">
        <property type="nucleotide sequence ID" value="XM_009545779.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_237589"/>
    <dbReference type="eggNOG" id="ENOG502QVFG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028299_1_0_1"/>
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    <dbReference type="OrthoDB" id="2128042at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Kch1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424:SF1">
        <property type="entry name" value="LOW AFFINITY K(+) TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16944">
        <property type="entry name" value="KCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW84399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="49340" checksum="00349E4672E2F5F7" modified="2014-03-19" version="1" fragment="single">MCGGPAWKREIVQDHKFDFVDTREFTDNGFGMRMKYLWLYIIVLKSFLVYISDIFTAITMLTTSSWSNQIFNNCPATEDNGCVFIPFNVGKWLFVGCIIFSFLLLAYEARKAKKIIASRDISYAFTNVMANHYYSLRSYDHFCFFDHISQSTKKKDDFAFFVFFTFKSWKRLLLADGPRQAINALTLYAIYLAKRDDGAWYDVGKYFAGNTLITTALTISTLFTTLVFAGSLLLLIIAGICYIPLLCYIQGNLKEYVCHKVDKRIAEIIKRRNKQRLAKAAALARKEAAGDYSHLKNKKGELVHKPLPQPTLPNISLDDDVDDRSSIRTRGPPPSVYTNATGTDQFYASDYKGAIDYPPMPAYNQPYSNSQDPNAYAYYNASAPNVHEDSLYEDEYGSQAHLAVTAAPYAYQHDSVLENPHSAGLVHDPYDVYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGK4</accession>
    <name>W4KGK4_HETIT</name>
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        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_101216</name>
    </gene>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW84993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541890.1">
        <property type="nucleotide sequence ID" value="XM_009543595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGK4"/>
    <dbReference type="FunCoup" id="W4KGK4">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KGK4"/>
    <dbReference type="GeneID" id="20665747"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_101216"/>
    <dbReference type="eggNOG" id="KOG1472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015741_4_1_1"/>
    <dbReference type="InParanoid" id="W4KGK4"/>
    <dbReference type="OrthoDB" id="1937912at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="552"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="159"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW84993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="643" mass="71344" checksum="E397CAE955D7FB75" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGZ2</accession>
    <name>W4KGZ2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Thioredoxin protein disulfide isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TRX5_PDI</name>
        <name evidence="10" type="ORF">HETIRDRAFT_63361</name>
    </gene>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543294.1">
        <property type="nucleotide sequence ID" value="XM_009544999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGZ2"/>
    <dbReference type="FunCoup" id="W4KGZ2">
        <property type="interactions" value="267"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KGZ2"/>
    <dbReference type="GeneID" id="20678636"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_63361"/>
    <dbReference type="eggNOG" id="KOG0191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021868_1_1_1"/>
    <dbReference type="InParanoid" id="W4KGZ2"/>
    <dbReference type="OrthoDB" id="72053at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
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    <keyword evidence="8" id="KW-0732">Signal</keyword>
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    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
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            <end position="585"/>
        </location>
    </feature>
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        <location>
            <begin position="544"/>
            <end position="561"/>
        </location>
    </feature>
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        <location>
            <begin position="16"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
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            <end position="275"/>
        </location>
    </feature>
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            <end position="168"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045246"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW84595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="585" mass="64770" checksum="0D74CBD9280DFC60" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KH25</accession>
    <name>W4KH25_HETIT</name>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_314110</name>
    </gene>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
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                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_314110"/>
    <dbReference type="HOGENOM" id="CLU_1686826_0_0_1"/>
    <dbReference type="InParanoid" id="W4KH25"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844249" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="17977" checksum="259196171FB37E8A" modified="2014-03-19" version="1">MCIFLPLRLRSLFIFTCIPRGDGRGGVLLWIDDAFKWFGLRVVSCRTSLPFFNSGSASLHMSYTYWFSMIHLSSVFELHSHFFLSRSSSRIPLRARSPVRLRASLFSCACRVPTSWPRRPLCFFPFRSLAASVLSYSLFIPSMRKAALRPIFNSCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHD5</accession>
    <name>W4KHD5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_425969</name>
    </gene>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009546076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHD5"/>
    <dbReference type="GeneID" id="20674060"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_425969"/>
    <dbReference type="HOGENOM" id="CLU_804245_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHD5"/>
    <dbReference type="OrthoDB" id="10668022at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW84735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="382" mass="43569" checksum="8633135A56ED9970" modified="2014-03-19" version="1">MPIPIGFERDQIYKCLGDRLTKLEVDRSKGEIERMFTELQQKNADLELRCRRLEDQINILHRALVELQNEKIWLEIRFAWMLFPRRLDSEKRPDFTTRMRTPSPDRMSQASDNEHGSWLQEEDGGPINSICIQEATDSVHSSTTNDRPAYTGFMPPRMSPFCKDEFALHGCLEHVREVKSLPLLLIRALTSDGHSDMRYKMSIQQVTLAHYFEDTDISNQSLRNSLGFIITSSDAFVKEESSEETVVMIRLQLIIQERVQGKKTGKKSGDGPVRQWRSRRNNLTKILNRNSELIVHLPDGYFYLGTFSGQGITVLNCDEFQALDLPVREAVIRATAGNVAMTLKLFEEISCAYSLGKLLACRVALKKTGFNDALAGALRTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4KI03</accession>
    <name>W4KI03_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_448449</name>
    </gene>
    <organism evidence="6 7">
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        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542175.1">
        <property type="nucleotide sequence ID" value="XM_009543880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KI03"/>
    <dbReference type="STRING" id="747525.W4KI03"/>
    <dbReference type="GeneID" id="20675860"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_448449"/>
    <dbReference type="eggNOG" id="KOG1472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129458_1_0_1"/>
    <dbReference type="InParanoid" id="W4KI03"/>
    <dbReference type="OrthoDB" id="1937912at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 4" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Bromo" evidence="5">
        <location>
            <begin position="9"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW85309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="100" mass="11800" checksum="E38D386A334E15F8" modified="2014-03-19" version="1">METIRSDLQAHPQAWPFKEPLNAQKAPDYYDVMRNPMNFFTMEHKLEKGQYADLDAFITDAQLVFDNAKVYNPEDTIYYKGAVKMERVLMDHVIRVREIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4KI74</accession>
    <name>W4KI74_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sulfate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_32618</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">High affinity uptake of sulfate into the cell.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541745.1">
        <property type="nucleotide sequence ID" value="XM_009543450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KI74"/>
    <dbReference type="FunCoup" id="W4KI74">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KI74"/>
    <dbReference type="GeneID" id="20671219"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_32618"/>
    <dbReference type="eggNOG" id="KOG0236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003182_8_0_1"/>
    <dbReference type="InParanoid" id="W4KI74"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902434">
        <property type="term" value="P:sulfate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000046">
        <property type="entry name" value="Solute carrier family 26 (Sodium-independent sulfate anion transporter), member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="467"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="10">
        <location>
            <begin position="528"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="660"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW85547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="755" mass="81974" checksum="F23EC07D2E834729" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIB0</accession>
    <name>W4KIB0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AAA family ATPase, CDC48 subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_458339</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544405.1">
        <property type="nucleotide sequence ID" value="XM_009546110.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="W4KIB0">
        <property type="interactions" value="553"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KIB0"/>
    <dbReference type="GeneID" id="20676902"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_458339"/>
    <dbReference type="eggNOG" id="KOG0732">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000536_5_2_1"/>
    <dbReference type="InParanoid" id="W4KIB0"/>
    <dbReference type="OrthoDB" id="5421at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001218">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000061">
        <property type="entry name" value="ATPase family, AAA domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
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</entry>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
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                <person name="Cullen D."/>
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                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
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                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Fossdal C.G."/>
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                <person name="Hietala A."/>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF27">
        <property type="entry name" value="BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="7">
        <location>
            <begin position="407"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW85585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="851" mass="93536" checksum="15482586F9A7A6BC" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKI6</accession>
    <name>W4KKI6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_470663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542428.1">
        <property type="nucleotide sequence ID" value="XM_009544133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKI6"/>
    <dbReference type="STRING" id="747525.W4KKI6"/>
    <dbReference type="GeneID" id="20677356"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_470663"/>
    <dbReference type="eggNOG" id="ENOG502S4SP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048757_0_0_1"/>
    <dbReference type="InParanoid" id="W4KKI6"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF105">
        <property type="entry name" value="DAGKC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="408" mass="44283" checksum="39328AD6A0D0460E" modified="2014-03-19" version="1">MPLLVLYNPVSGNSSGKQIVEEHILPLLSKHGKVTDRVVSTERPGHAGSLVVNFIDQFPAKDRVVIDIVLVSGDGTLHEIVNLLDEECARRGDSKPFPRFRIALIPGGTANALHSSFFPQSTGTETSSHQFASLDAFLGPTPSAKTLTLSHTVITPPHASSQDSETRAHTSVVSVVVTSTSLHASILHDSEALRKGMPGIERFKVAAQQNATRWYHSRVRLLPFPPSSSVQRYDPVTDAFVPVSEAETELDGPFAYFLSTINVDRLEPAFRISPLARSHPSASTNHEDGAIDVVVVRPKRDPSVKDETEETRTRFTGKAWQVLGSAYADGAHVKLRYGAEGEVGEGGIGLPVVEYFRVGGWEWIPDKADEEARLLCADGTIFTIPPGGKALSMILSQTSHKLDLAVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKJ9</accession>
    <name>W4KKJ9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_31769</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541730.1">
        <property type="nucleotide sequence ID" value="XM_009543435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKJ9"/>
    <dbReference type="FunCoup" id="W4KKJ9">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="GeneID" id="20670440"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_31769"/>
    <dbReference type="eggNOG" id="KOG0988">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001366_2_1_1"/>
    <dbReference type="InParanoid" id="W4KKJ9"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="2">
        <location>
            <begin position="123"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW86342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="926" mass="104498" checksum="563ABA954A93452D" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KL29</accession>
    <name>W4KL29_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_145763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542842.1">
        <property type="nucleotide sequence ID" value="XM_009544547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KL29"/>
    <dbReference type="GeneID" id="20667098"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_145763"/>
    <dbReference type="HOGENOM" id="CLU_1791460_0_0_1"/>
    <dbReference type="InParanoid" id="W4KL29"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="145" mass="15248" checksum="D909B40749053533" modified="2014-03-19" version="1" fragment="single">MHADDRHSAPHTRAARLRRTGTSRCSRTSSAASPPPRPARCPARPRRRPPHVPAPGSPSAAPVPQMTPSATRGHTAVAAPRTPRRSPRLALLPHSSPSRSRRARNRTQQTHRDAAAAAAVAGGAAVVAAAAAGSRGGSWRSARWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLD2</accession>
    <name>W4KLD2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_471043</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542662.1">
        <property type="nucleotide sequence ID" value="XM_009544367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLD2"/>
    <dbReference type="FunCoup" id="W4KLD2">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KLD2"/>
    <dbReference type="GeneID" id="20677375"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_471043"/>
    <dbReference type="eggNOG" id="KOG1068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063514_1_2_1"/>
    <dbReference type="InParanoid" id="W4KLD2"/>
    <dbReference type="OrthoDB" id="2504340at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11371">
        <property type="entry name" value="RNase_PH_MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF2">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="9">
        <location>
            <begin position="56"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="185"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW85846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="270" mass="29248" checksum="0B79BCBB86A9D987" modified="2014-03-19" version="1">MALAAFDRRRINGPDESFPPVFDESESADTSYSSWTVGEARQGRQPLDIRPICAQVVLKAGLISQANGSAYIETERTKVACAVYGPRQSKNTGYNENGRLNVEVKFAPFSCGKRRAPLRDAEDRSIAVLIQQALIPSVRLELLPKSVIDIFITVIECDGIEGCIAVASVAASTALADARIELLGLAVACSACVVNREIWLDPTEEEGHLAEGSLVFACIPALGIVTNTWQTGRILPQDTLQCLESCQERCTDIHQIVSRALLDSAEKSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLF9</accession>
    <name>W4KLF9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_306035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540664.1">
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    </dbReference>
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            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
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        <location>
            <begin position="152"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="596"/>
        </location>
    </feature>
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        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="613" mass="67296" checksum="92858EBAB04F48EF" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLQ0</accession>
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        <recommendedName>
            <fullName evidence="7">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="8" type="ORF">HETIRDRAFT_308558</name>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_308558"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_315479_0_0_1"/>
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    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FOUR AND A HALF LIM DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205:SF16">
        <property type="entry name" value="GH01042P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="725"/>
            <end position="788"/>
        </location>
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        </location>
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        </location>
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        <location>
            <begin position="822"/>
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        </location>
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        <location>
            <begin position="893"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="935"/>
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        </location>
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        <location>
            <begin position="70"/>
            <end position="110"/>
        </location>
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            <begin position="119"/>
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        </location>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW85981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Bondarzewiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the SIKE family.</text>
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    <dbReference type="STRING" id="747525.W4KLX7"/>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_306225"/>
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    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008555">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05769">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
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            <begin position="80"/>
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            <begin position="187"/>
            <end position="196"/>
        </location>
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    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW86807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
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    <name>W4KMA8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="11">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_468124</name>
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    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the C-terminal section; belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="11"/>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540529.1">
        <property type="nucleotide sequence ID" value="XM_009542234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMA8"/>
    <dbReference type="FunCoup" id="W4KMA8">
        <property type="interactions" value="312"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KMA8"/>
    <dbReference type="GeneID" id="20677214"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_468124"/>
    <dbReference type="eggNOG" id="KOG1371">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_10_1"/>
    <dbReference type="InParanoid" id="W4KMA8"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF47">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01713">
        <property type="entry name" value="NUCEPIMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 11" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="12">
        <location>
            <begin position="10"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW86515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="377" mass="41911" checksum="75A8FE006541226D" modified="2014-03-19" version="1">MSTDSSLKRVLVTGGAGYIGSHVVYALQATRRYKVICIDNYHNSYPKALTRLTQIAHDALPENATEQDKDSTEIDSYNVNLTHPEEVRAVFEKYGKGGIWGVIHIAAYKAVGESTEIPVTYYHNNVSATIFLLQAMSEFDCTRFVYSSSATVYGTPPKVPIPETTRLKADSPYGKSKVMSETIIDDLAHAEPERWRAISLRYFNPAGAHPSGLIGEDPRGRPGNLLPLLAHMAIGRVKDDKLRVFGNDYPTPDGTCVRDYLHVLDLASGHLLALDALAPESTIFDNCPDEARYKAYNLGKGKGMSVLQIVDAMRKATGFDYKYEIVGRRRGDVPDLTADPSLAEKELKFKAPQDLETMCKDLWNWQTKNPLGYESEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMB8</accession>
    <name>W4KMB8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_166472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540913.1">
        <property type="nucleotide sequence ID" value="XM_009542618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMB8"/>
    <dbReference type="GeneID" id="20668054"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_166472"/>
    <dbReference type="eggNOG" id="ENOG502QUEX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088979_2_0_1"/>
    <dbReference type="InParanoid" id="W4KMB8"/>
    <dbReference type="OrthoDB" id="425354at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053037">
        <property type="entry name" value="Pericyclase_pydY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115:SF1">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="187" mass="21076" checksum="F74FF00DA05A2CA8" modified="2014-03-19" version="1">MAAPSSLTTLDLSGQYVMNKSLSDSTDEILRLQGVSWFTRKAIGIATLTLSVKHYKDDAGVEHIDIDQTITGGIKGTTEIRVLNWEAREHEDHIFGFVVGRSRRIRVEDIEHEFLRVGWLPDTTEHGAVNSYVESDTPKSGTSWTAEQIWGFEEVNGERRYVRHIRFIGPGGENIQARLVYDYNGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMH3</accession>
    <name>W4KMH3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycosyltransferase family 23 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_307790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540965.1">
        <property type="nucleotide sequence ID" value="XM_009542670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMH3"/>
    <dbReference type="STRING" id="747525.W4KMH3"/>
    <dbReference type="GeneID" id="20669526"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_307790"/>
    <dbReference type="eggNOG" id="ENOG502SM7G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032339_0_0_1"/>
    <dbReference type="InParanoid" id="W4KMH3"/>
    <dbReference type="OrthoDB" id="423313at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046922">
        <property type="term" value="F:peptide-O-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045130">
        <property type="entry name" value="OFUT2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13398">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13398:SF0">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844361" description="Glycosyltransferase family 23 protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW87012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="49245" checksum="6E34E4C13461BFFE" modified="2014-03-19" version="1">MLAACTLFSAVTLFAFVLFNYAQPKFPFETPELLPHAPQSAAGVDRHSVLLGPPTSHFRDNLRNDTRYITSWISAGWTNDVMTYGNLVYLAMISQRVPIIGPFTPSHIGGEAGSIPFSEVFDLDRLSTAIGMSVVEWGEVKDPASTEIENLGCWSIWQAVQTNEAGPRITGALSQDISYTKAPSWVQKNPGYEHDPHAHFWSIATLTFPEERRNNLGTPQPSNVLGAVAHPDEQVACFDYLYYVCATTSFEYEYDYSPGWRFAVKNFRWTDRLQGIADGYLKRMFGVPEEEPVPPYVGIHIRHGDFINYCGETPKEDCFASLSVVARRVQEVQDEVQERYGYRPERVVMLSDEREPGWWDAVRLLGWYTPDHIAEDTTAKYGRWYPLLIDAVIQSSGIGFVGTDTSTMSVLARRRVQDWHGGAVRTVKWGTPNADDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMK7</accession>
    <name>W4KMK7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_59051</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probably involved in the biogenesis of the COX complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SURF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540395.1">
        <property type="nucleotide sequence ID" value="XM_009542100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMK7"/>
    <dbReference type="FunCoup" id="W4KMK7">
        <property type="interactions" value="363"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KMK7"/>
    <dbReference type="GeneID" id="20678461"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_59051"/>
    <dbReference type="eggNOG" id="KOG1563">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047737_4_2_1"/>
    <dbReference type="InParanoid" id="W4KMK7"/>
    <dbReference type="OrthoDB" id="10040024at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF2">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW87052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="217" mass="24408" checksum="2B553B7F8611A91D" modified="2014-03-19" version="1">MLVLGTIPIFTFALGTWQVQRLKWKVSLIDELTEKLEREPLSLPNKVNIAAIPDFIYRKVVLRGVWDDAHAMLLGPRVRDGTNGYHLITPLIRSNGSTVLVDRGFISGDFVKSGKRTPKVQSEVEVCGMLRDSQARNSFTPDNHPEKGEWYWADLDAMTEYAGGEHLNVQPVLVEEIFDASYRLTRGIPIGKAATVDVRNAHASYVVTWWVSSSQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPB6</accession>
    <name>W4KPB6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_306947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541552.1">
        <property type="nucleotide sequence ID" value="XM_009543257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPB6"/>
    <dbReference type="GeneID" id="20669445"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_306947"/>
    <dbReference type="HOGENOM" id="CLU_3143247_0_0_1"/>
    <dbReference type="InParanoid" id="W4KPB6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="49" mass="5639" checksum="1D25A050A9AA4DF1" modified="2014-03-19" version="1">MEQNDVAFYSHAVFLLRLTDLRFHADSVRKQGSRGLDDESDDLWLGGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPM0</accession>
    <name>W4KPM0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_145630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541626.1">
        <property type="nucleotide sequence ID" value="XM_009543331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPM0"/>
    <dbReference type="GeneID" id="20667092"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_145630"/>
    <dbReference type="HOGENOM" id="CLU_2109352_0_0_1"/>
    <dbReference type="InParanoid" id="W4KPM0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW87762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="13334" checksum="A36B26DA1E40AC51" modified="2014-03-19" version="1">MVSTAIVDMMAHWVAKKVSTENVDAQVTVVGLEFWNELEKAKNRTYYSSSPSPRFLNKLEQTLRSENRRLVFPVFLAKEKHFIAMQVCCKENTIVSGKSTHLHHLKKQRLNQTCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4KQQ0</accession>
    <name>W4KQQ0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_413681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541279.1">
        <property type="nucleotide sequence ID" value="XM_009542984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KQQ0"/>
    <dbReference type="STRING" id="747525.W4KQQ0"/>
    <dbReference type="GeneID" id="20673124"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_413681"/>
    <dbReference type="eggNOG" id="KOG2852">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_14_1_1"/>
    <dbReference type="InParanoid" id="W4KQQ0"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF185">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_3G02360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="410" mass="42600" checksum="F7088C8A0EB784BB" modified="2014-03-19" version="1">MSSPGTENVVIVGAGIIGVATAYHLSLLSPTTTIHLVEAAPTLFHSASGKAAGFLARGWFAPASAALGALSFDLHRKLAAEHGGGKAWAYSPSTAYSISDAQAPESAERGEDWLFQGTSRALMAGGGAQQRSGAPEWLAVGRAGETSGVEKISDPSGTAQVDPLLLSQFLLDQARSRGVQLHHPATPTGVVTSPSNALTGLTIRTADGAEQTLPCDSLILTAGVWTPRVFSTLFPSSSTRLPITQLSGYSLVLRSPHWAEDPYTDDSPRTSHAAFTTDPAAGFSPEIFSRASGDIYLAGLNTTDVPVADVGAHVVPEPREIARLKDVAKKMLGTEQLDILSEGLCHRPVMPTGMPLLTALSEHQTGVVGKVWVSSGHGPWGISMSLGTGLVLAEMALGKAPSADVSQLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMJ0</accession>
    <name>W4JMJ0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_165026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553234.1">
        <property type="nucleotide sequence ID" value="XM_009554939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JMJ0"/>
    <dbReference type="GeneID" id="20667959"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_165026"/>
    <dbReference type="HOGENOM" id="CLU_1372369_0_0_1"/>
    <dbReference type="InParanoid" id="W4JMJ0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW74748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="199" mass="21966" checksum="CD5858D7DC4FF647" modified="2014-03-19" version="1">MTRYTSRTSTLSPTVGDQEGQKRQFDIDINTDDGYTLSAFGDISIFDGFFILTSTSLVDVDVGSSRRRIRTRRPPMPRKFSSRSVSDYEETAREYPRFPFPDLPTPTSPYSAEAEFEALFQSLKSHRASYTAPSHNLATRSLAGKPTLRVETSGLSDRRIPLRGFSRASNSGASPSLGALPRQSPGIALSASPIHRETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPL1</accession>
    <name>W4JPL1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_461341</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552919.1">
        <property type="nucleotide sequence ID" value="XM_009554624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPL1"/>
    <dbReference type="STRING" id="747525.W4JPL1"/>
    <dbReference type="GeneID" id="20677160"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_461341"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="InParanoid" id="W4JPL1"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW75512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="331" mass="36334" checksum="75C0D57FFC09833F" modified="2014-03-19" version="1">MTAADVPSFALNNGSTVPSIGMGCWMGSPGGGERVKEMCDKALTVGYRHFDTASGYANEAKVGLAIAESGIPREQLYVTTKLWNGDHHRVREAFEESLAKLNCDYIDLYLMHWPQAVSAQGVTLQADEYPTIIDTWKEMEKLVDTGKVKSIGVSNFSIKTLTRLLPHCRIFPATNQVELHPYLPQTKLKAFCEERGILLTAYSPIGSPYASSGGLDTTVPTLVADPTVQAIADKHGATPAQALINWAVQRNTIVIPKSENLDRMTANITLVKLDDADMQALNVLHERPGMHRSLLSSYHDNNGSVFGWTYEQLGWDMKLGGIVAEQSRSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPU1</accession>
    <name>W4JPU1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-ribosomal peptide synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_164901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553356.1">
        <property type="nucleotide sequence ID" value="XM_009555061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPU1"/>
    <dbReference type="GeneID" id="20667947"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_164901"/>
    <dbReference type="eggNOG" id="ENOG502QQU2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005562_0_1_1"/>
    <dbReference type="InParanoid" id="W4JPU1"/>
    <dbReference type="OrthoDB" id="3142841at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW74891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="55931" checksum="F3CC6FDEF8F34A8D" modified="2014-03-19" version="1">MSQPVVIGDPEKGTMDLVLPAELPPIHAKDLHNSSYMSEKSNVTSSVVTPTLPLKHQDDRKLKPQPKKRAGWRIRALLWFNTYRKFFTVIVTLNGVGILLAALDIWHYPRKYTSALVLGNLLTAILMRNELFGRLLYLMVNTLFAKWTPLWFRLGCTSALQHLGGIHSGCATSGFAWLIFRVTLIFINHKNNHDAILVTGVVTNIAVAISIASAFPWVRNTHHNVFERHHRFIGWLGLLSTWVFVVLGDSYDLTTHSWNPDGATILRHQDFWFAFGMTVFILIPWFTVREVEVDVEVPSPKVAILRFKRGMQQGLLARISRSSIMEYHAFGIISEGTHAKYHYLICGVQGDFTRSLVTNPPTHIWTRQLKFAGVSNTSALYHRGIRVCTGTGLGAALSTCLQSPNWYLIWIGSDQEKTFGPTISGLIHRHIGPERMCLWDSKQRGGRPDVMKLVKETYASWGAEVVFITSNYQGNTEIMEGCKEAGIPAFGTLWDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQE9</accession>
    <name>W4JQE9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">orotate phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_329320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="5"/>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552033.1">
        <property type="nucleotide sequence ID" value="XM_009553738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQE9"/>
    <dbReference type="FunCoup" id="W4JQE9">
        <property type="interactions" value="307"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JQE9"/>
    <dbReference type="GeneID" id="20671483"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_329320"/>
    <dbReference type="eggNOG" id="KOG1377">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074878_0_0_1"/>
    <dbReference type="InParanoid" id="W4JQE9"/>
    <dbReference type="OrthoDB" id="5553476at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046132">
        <property type="term" value="P:pyrimidine ribonucleoside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683:SF1">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="9">
        <location>
            <begin position="76"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW75777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="229" mass="24766" checksum="743310D12DCE5DF0" modified="2014-03-19" version="1">MASTLQPYQVELIDNAMLIGALKFGSFTLKSGRVSPYFFNAGLLSTGPLLTTLCTAYSSVIASALSPSSSLPLPEFDVLFGPAYKGIPLAACTAMLLHLQHDISVGLAYDRKEVKDHGEGGNMVGVSVRGKRVLILDDVMTAGTAVRGAIETIRREGGEVVGVVMCLDREEIGKGNSSTVQELESELGGEGRVQAIVKMRDLMKWLEKKGMDEDLSGMRQYWEKYGVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQU5</accession>
    <name>W4JQU5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_461322</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
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        <property type="protein sequence ID" value="ETW75455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009554577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQU5"/>
    <dbReference type="FunCoup" id="W4JQU5">
        <property type="interactions" value="620"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JQU5"/>
    <dbReference type="GeneID" id="20677156"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_461322"/>
    <dbReference type="eggNOG" id="KOG2001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007738_0_1_1"/>
    <dbReference type="InParanoid" id="W4JQU5"/>
    <dbReference type="OrthoDB" id="2192946at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000011">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="7">
        <location>
            <begin position="101"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="478"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW75455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="823" mass="93081" checksum="302B82BDD4359CC5" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQV9</accession>
    <name>W4JQV9_HETIT</name>
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        <recommendedName>
            <fullName evidence="1">phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_152470</name>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026170_0_0_1"/>
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    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016314">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305:SF81">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01301">
        <property type="entry name" value="PTPlike_phytase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatase tensin-type" evidence="5">
        <location>
            <begin position="16"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="102"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="306"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="629"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="629"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW75923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="753" mass="80941" checksum="6F2441044622F338" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQY5</accession>
    <name>W4JQY5_HETIT</name>
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        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_331537</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552709.1">
        <property type="nucleotide sequence ID" value="XM_009554414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQY5"/>
    <dbReference type="STRING" id="747525.W4JQY5"/>
    <dbReference type="GeneID" id="20671666"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_331537"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="InParanoid" id="W4JQY5"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW75276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="30512" checksum="C8D13D6DDE1C52E9" modified="2014-03-19" version="1" fragment="single">GASSGLGLALTKRVLARGDRVIAAVRTPSKLSNVFSDDESSRVNVLEMDVTEPYSQIKGKIDSAVKKWGPVDVLVNNAGLGIMALTEEGGCETMMQQMQTNFFGVLNVTNAVLPYLRERMRGTIVIIGSRSAWRNEFAVRLYSASKAAVHSYGETLAAELQPFNIRVLIVAPGSFRTPGIYPPTIVGDPLPGYERLRADTEKRLTTLVTRPNQGDPMRGMDVVVDVVKGEGREEPSEWPLWLFLGEDAMSDVRAKIGRITKALDAWESVGSNLGFLEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4JR36</accession>
    <name>W4JR36_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_237994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552256.1">
        <property type="nucleotide sequence ID" value="XM_009553961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JR36"/>
    <dbReference type="GeneID" id="20668800"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_237994"/>
    <dbReference type="eggNOG" id="ENOG502SB62">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_486667_0_0_1"/>
    <dbReference type="InParanoid" id="W4JR36"/>
    <dbReference type="OrthoDB" id="5396786at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013877">
        <property type="entry name" value="YAP-bd/ALF4/Glomulin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08568">
        <property type="entry name" value="Kinetochor_Ybp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="487" mass="50709" checksum="10BD1CFE0F88044D" modified="2014-03-19" version="1" fragment="single">AEGVLVVLGDAASAKEVVMGAQEIVERLEAEEEGDEDDNGGADKEPSAKASLATQVARLMALYARVVPRLNQRRPALDTLQSIAPDLEPLVYRAAARATATESRALVVAASGLAMSARAWAQAQTKAGDDADALALARCTVLLASVLDATLEACAGRVACSRAQRAFEARFPRLVVRSAVRSGWEAGEDAMSAAALGRTSASLLSNPSIAALILLAHASPPEPLTPAALTPLLPVLLSALDIGIADEPLYLLLVALLPSPASSHTPTSTGTGAELPPDLVLPLTPVLASLCSAHPDPPTRHLAFRLLSLALRATPAPLRLQVLRDLTDPAEDAHPPQMRAAAVGLVKESVLAALAATEPGAPAGSADAGVDVFASPALLGALGAHVFRAHPPDLFVAESTPADAFMRSAEPARLAECLALYYVLLRRDVQNRTGIRDLDTIRNIEQTFVGPMRAAVARWLAALGDELHAVMPLAALQTNIERVDAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4JR80</accession>
    <name>W4JR80_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DEAD/DEAH box helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_53821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551859.1">
        <property type="nucleotide sequence ID" value="XM_009553564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JR80"/>
    <dbReference type="GeneID" id="20678274"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_53821"/>
    <dbReference type="HOGENOM" id="CLU_3147183_0_0_1"/>
    <dbReference type="InParanoid" id="W4JR80"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="49" mass="5610" checksum="BF9F555F8F3314AD" modified="2014-03-19" version="1" fragment="single">TGSGKTLTFWMLLLFASRIQIIVTPLNILGKQNKDDLRNIWKPLPCIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSR7</accession>
    <name>W4JSR7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_411936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551494.1">
        <property type="nucleotide sequence ID" value="XM_009553199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSR7"/>
    <dbReference type="GeneID" id="20672980"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_411936"/>
    <dbReference type="HOGENOM" id="CLU_121528_0_0_1"/>
    <dbReference type="InParanoid" id="W4JSR7"/>
    <dbReference type="OrthoDB" id="3266090at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="134" mass="15821" checksum="D1D8AD09CA77CCF2" modified="2014-03-19" version="1">MQQLPAKLDAEITHTGALLSFGLGITYEHLLAYAAKRNIRASWAPDEAITSPVVAWVRIARLFMERIPGFLVYYRRPFSVHYEGLLALYSNHSMRELQRRGEAHEKRIIEFLQKEMELDSTPMWYWDMDYTSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSU1</accession>
    <name>W4JSU1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_422026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551495.1">
        <property type="nucleotide sequence ID" value="XM_009553200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSU1"/>
    <dbReference type="GeneID" id="20673771"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_422026"/>
    <dbReference type="HOGENOM" id="CLU_2527740_0_0_1"/>
    <dbReference type="InParanoid" id="W4JSU1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="84" mass="9451" checksum="BBD66BD538D3A708" modified="2014-03-19" version="1">MTRTDGSGGGYLIIYLSERAVVIVVVVAFGFDFRGVCARLFSVYKFESVAGGPACEKPQYSLHYRLIRSYPFKDVDITSLRPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>W4JT93</accession>
    <name>W4JT93_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_460734</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551230.1">
        <property type="nucleotide sequence ID" value="XM_009552935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JT93"/>
    <dbReference type="GeneID" id="20677105"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_460734"/>
    <dbReference type="eggNOG" id="ENOG502QSY2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006019_2_2_1"/>
    <dbReference type="InParanoid" id="W4JT93"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW76305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="898" mass="99356" checksum="8874CD5CD59F7BB6" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTW0</accession>
    <name>W4JTW0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_441659</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550559.1">
        <property type="nucleotide sequence ID" value="XM_009552264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTW0"/>
    <dbReference type="STRING" id="747525.W4JTW0"/>
    <dbReference type="GeneID" id="20675381"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_441659"/>
    <dbReference type="eggNOG" id="KOG1472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015741_0_0_1"/>
    <dbReference type="InParanoid" id="W4JTW0"/>
    <dbReference type="OrthoDB" id="1937912at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 4" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Bromo" evidence="5">
        <location>
            <begin position="96"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW77002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="187" mass="21354" checksum="B61A1EAC9D9E424B" modified="2014-03-19" version="1">MQCTMLRKVGYLVTKEIVAQQREAILAKIRQMSKSRIVYEGLPQFQDGKGEGLVIDPKDVPGLRESGWMPNINVPARPSTKNFERSAMESILSDLQAHPQAWAFKEPVNAQEVPDYYDVIQNPMDFSTMVHKLETGQYQDLDAFIADAQLVFDNAKVYNPEDTIYYKGAVKMERVLMDHVSRVRKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4JU58</accession>
    <name>W4JU58_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_480534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JU58"/>
    <dbReference type="GeneID" id="20677918"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_480534"/>
    <dbReference type="HOGENOM" id="CLU_024199_2_3_1"/>
    <dbReference type="InParanoid" id="W4JU58"/>
    <dbReference type="OrthoDB" id="3258333at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="35"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="548" mass="61398" checksum="CD7B723734F9C6A5" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVU6</accession>
    <name>W4JVU6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_326894</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JVU6"/>
    <dbReference type="GeneID" id="20671278"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_326894"/>
    <dbReference type="eggNOG" id="ENOG502S3G3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_676251_0_0_1"/>
    <dbReference type="InParanoid" id="W4JVU6"/>
    <dbReference type="OrthoDB" id="8955945at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="285"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW76991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="407" mass="45613" checksum="77FA57CF9884A613" modified="2014-03-19" version="1">MSGQASTSTNTPSATVQPGRGKVKLPDNYTGDRIESQKFMLQCLLLFAAESDRYKTDQDKISLVLSCMRYGTAGAWAENFLLKSVGADPPTDLGTWKDFLAKFKLQFRETGKTDKARSALMAFSQGRMTVDEYSNQFILIAADADISDKEQVPYFQRRLDPRVMDKIYDKEVQPKDTIQDWINTACEIDGRLRARTAQKAILANSTSFRSDYLNRFHNQISPRYNSTNAPRRMNNQVVDMDIDATRKRNAHSQKRKYDGKPPSTCYHCGKTGHWNTDCPSRCRGVQPTRGNSKRRMGTTGRRSRAVDLEGEDDAPAMGNQAGIYRGMETEDVPRNDQRVPQPGPSMERPHSTSSGRPQTNHGQRAMLPNGRQRDGSVSHSARIGAVLGELGEDEAREVILGHAEHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVV5</accession>
    <name>W4JVV5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_174333</name>
    </gene>
    <organism evidence="4 5">
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        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550558.1">
        <property type="nucleotide sequence ID" value="XM_009552263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JVV5"/>
    <dbReference type="FunCoup" id="W4JVV5">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JVV5"/>
    <dbReference type="GeneID" id="20668508"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_174333"/>
    <dbReference type="eggNOG" id="KOG1472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086729_0_0_1"/>
    <dbReference type="InParanoid" id="W4JVV5"/>
    <dbReference type="OrthoDB" id="1937912at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="198"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW77001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="280" mass="30945" checksum="0B58339626420316" modified="2014-03-19" version="1">MYHFTAPSSTDKLPPSSVSSQLDEELLQPPAKRRRISSSSLSDAEDDEDENRPFASRMVGTHVSSNGTRPHGRRSGKKASSMKSKAQTAPASIPPPTGEQQAEMNGEFLQLNGHEPPVKMEDQLDEGQLDLLATGVTVDTASAATISPPLKPEKISAKELRKGVIKILPIENDGQPRSFVILTNLKTLFQKQLPAMPREYIARLVYDSNSKCLAICKRGYKVVGGICYRPFPHRGFAEIVFFATASADQVKGYGALLMDHFKAHIRRTYPRHDAFSDIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4JW72</accession>
    <name>W4JW72_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Steroid 5-alpha reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_453910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549812.1">
        <property type="nucleotide sequence ID" value="XM_009551517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JW72"/>
    <dbReference type="GeneID" id="20676446"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_453910"/>
    <dbReference type="eggNOG" id="KOG4650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043418_1_1_1"/>
    <dbReference type="InParanoid" id="W4JW72"/>
    <dbReference type="OrthoDB" id="67965at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF15">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="38023" checksum="B8185071B350849B" modified="2014-03-19" version="1">MAPVHALDPYYLGLAILVTTGYQLLGFAIAWTFQFDKITDFTGGGCSNFLLLALLTLLIGNTFYVRNVVASVLVMVWATRLAGFLLFRVLKVGSDARFDEIRSHFFKFFAFWIGQIVWVWTVSLPVIILNSPAVSDPARGGVNPAFGTSKDIAGIVIWALGWIVETVADAQKFYYKSTKPPRNQPNTYGIWAWSRHPPYFGEIMCWWGIWILTISPSTNGALAGSAKAAQYGSVVSPLFTTLLLLFGSGVPTAEKPSARRFYLMTHGPRAPDEGVSAWTAYKAYLRSTSLLVPLPPALYRRLPEIVKRTVLLDWPIYRFDEKTDGPRAIEEERRKLGEGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4JW94</accession>
    <name>W4JW94_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Pterin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HETIRDRAFT_65517</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19949"/>
            <dbReference type="ChEBI" id="CHEBI:17836"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="EC" id="2.5.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the C-terminal section; belongs to the DHPS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the N-terminal section; belongs to the DHNA family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550521.1">
        <property type="nucleotide sequence ID" value="XM_009552226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JW94"/>
    <dbReference type="FunCoup" id="W4JW94">
        <property type="interactions" value="196"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JW94"/>
    <dbReference type="GeneID" id="20678738"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_65517"/>
    <dbReference type="eggNOG" id="KOG2544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008023_2_0_1"/>
    <dbReference type="InParanoid" id="W4JW94"/>
    <dbReference type="OrthoDB" id="615426at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="entry name" value="7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="entry name" value="Dihydropteroate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="FOLATE SYNTHESIS PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941:SF1">
        <property type="entry name" value="FOLIC ACID SYNTHESIS PROTEIN FOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="Dihydropteroate synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="16">
        <location>
            <begin position="406"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETW77350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="722" mass="79005" checksum="3A45497585D65DC4" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWS3</accession>
    <name>W4JWS3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor ISY1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_421663</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ISY1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551028.1">
        <property type="nucleotide sequence ID" value="XM_009552733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWS3"/>
    <dbReference type="FunCoup" id="W4JWS3">
        <property type="interactions" value="589"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JWS3"/>
    <dbReference type="GeneID" id="20673740"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_421663"/>
    <dbReference type="eggNOG" id="KOG3068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043453_0_1_1"/>
    <dbReference type="InParanoid" id="W4JWS3"/>
    <dbReference type="OrthoDB" id="1739576at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="220"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW77540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="39358" checksum="8C3515C53D0863F3" modified="2014-03-19" version="1">MARNEEKAQSMLYRFREAQAAELGLGTRSDRRPRMASACKSLRDCERWRGEILREISRKVSKIQDGQCPHCNGASFKLICRNTAGLSDYEVRDLNDDINKLMREKRHWENQIVALGGANYRRNVAMLDDDGREVPGTKGYKYFGRAKELPGVRELFESRKKEEDEETATQSFFRRFTNQGPSYFGDLDEADGSLLQYEQDAEQEEWNEAYENLRETLGLPADEPIPKIPRSNVSHPSQTLPPSDPPPLSSDAKRKAPSDDNDEKDDNQNSDAAKRSKTDAVVPSTGSERRTADPTDVLVAHARAAAAYIQFLEPENLLPPKMPSKEEMEGVLLELRKRALVDEYFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4JX86</accession>
    <name>W4JX86_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_445958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549727.1">
        <property type="nucleotide sequence ID" value="XM_009551432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JX86"/>
    <dbReference type="STRING" id="747525.W4JX86"/>
    <dbReference type="GeneID" id="20675660"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_445958"/>
    <dbReference type="eggNOG" id="ENOG502SPDB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021481_0_0_1"/>
    <dbReference type="InParanoid" id="W4JX86"/>
    <dbReference type="OrthoDB" id="5327923at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="478" mass="55354" checksum="FBD1C67EA7E51F18" modified="2014-03-19" version="1">MALIMNQPTRFVCQWWPRHPKGPTLRKEHAPTGYRTPNRIIWGHSIGDFYFIQRVPNTDVVTIWSRSMIHEFGENYASEAFEMEPHPRQRRPWPLLQIPKGHMLDDLYGIPDEGSEHGGCFERIVDDEEEGDHATYRSLKDLHADLKAEVASADKGDHEILAEMPPALEEFIPNEYLPDIILVDDTQRRVIDLSYHVADDETHRKLSSMPLKYRRVLPSLENLESTLKHQERRKVRQDKPAHELRVARLRLKAENKLGSGHHSDVYLAPLELPKPLTARTPSGAVAVAAKLAYPRREARSLLENEGSVYNAFPRHLQEEWCGYNLVPPIKHPVPVGAVVPKFFGYYKPVFDPNDLHISDEPIDSSAFSYDDKMECFSLPQRLHHEDFLQNSFYRRNILVQPGPLTVPPIQRSHKQPSFRIIDFGRTEDWGAVIDKVKRDNSAKDAAEILKINRDKLHFDKQHESKRAWEELSIDDYNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXP1</accession>
    <name>W4JXP1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_241805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550274.1">
        <property type="nucleotide sequence ID" value="XM_009551979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXP1"/>
    <dbReference type="STRING" id="747525.W4JXP1"/>
    <dbReference type="GeneID" id="20668904"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_241805"/>
    <dbReference type="eggNOG" id="ENOG502S93V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074638_0_0_1"/>
    <dbReference type="InParanoid" id="W4JXP1"/>
    <dbReference type="OrthoDB" id="6419443at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="53"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW78293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="220" mass="24890" checksum="50AC4A8376EB483E" modified="2014-03-19" version="1" fragment="single">DRDDSDDELVNVVSLPGTPARSRPSSRPPSPTRGAAARPLPRPLHLSARKSPADPLRAFPTEISQQIFRHLAIRDLAACSRVSKKWHKSQTLNYVWFQHYRKENFHDESLPQGKWTKRESKQSWIAMYAQFVLSRSPPLGPMRPYSRSSGYSTPTASGHQTPREQREERWRLEAEAVDKPGKLEMREMYKELGGRKSKAKTKLGGTAGVRDKGGWDAGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXP7</accession>
    <name>W4JXP7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_165522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550321.1">
        <property type="nucleotide sequence ID" value="XM_009552026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXP7"/>
    <dbReference type="GeneID" id="20667989"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_165522"/>
    <dbReference type="HOGENOM" id="CLU_2961065_0_0_1"/>
    <dbReference type="InParanoid" id="W4JXP7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="59" mass="6570" checksum="7E29337E518094FC" modified="2014-03-19" version="1">MQRLPASSASISPTFRLRVQIEKVVARDMGTCETRGITICRCARIKTLKVGPHWTSPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXS9</accession>
    <name>W4JXS9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_446170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550353.1">
        <property type="nucleotide sequence ID" value="XM_009552058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXS9"/>
    <dbReference type="GeneID" id="20675671"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_446170"/>
    <dbReference type="eggNOG" id="ENOG502QUXN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019029_0_0_1"/>
    <dbReference type="InParanoid" id="W4JXS9"/>
    <dbReference type="OrthoDB" id="10267139at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="entry name" value="CofD-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240:SF0">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="CofD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="479" mass="51843" checksum="B840564CFAEE96B7" modified="2014-03-19" version="1">MAALHLTAPDALLNSPGSSVFDLPTQPLQPSYIHPHSRLVNSHVSDTPEDRSFIIISGGTGCNAICAAFSQACYVLPVSDDGGSSSEIIRVLGGPSIGDIRSRLVRLMPSAPSGSPLDALRTLLAHRLPVNCSEQEARDQWRAIVEGRSALWVGIPNDRKETIRGFLVYFENEVLRRAHKNFSFLNGSIGNYFLAAAQGFFRSLPSAIFLFSSITGSQANILPVIVTNHTVTIAAELASGVSLIGQCEISHPVRKSSFSIDNDLDDSALNLASPTDDLRATLSKPKNMMFDAGSKVDFEALDAPISRLYYINAYGHEIHPSPNPDYLSNLRAREVLVYACGSLWTSIIPCLALRGVAAAIAGASSLRAKVLFLNSKNDRETDGYAATDYIDAIVRTLNASYRVEPYGLGHAATMYPVSAFITHLVYLRGTSVEVDIQRVTELGVRCVEVESDVLGDDAVPLYDAACARRAMEKILAKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JY10</accession>
    <name>W4JY10_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_243201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549794.1">
        <property type="nucleotide sequence ID" value="XM_009551499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JY10"/>
    <dbReference type="GeneID" id="20668971"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_243201"/>
    <dbReference type="eggNOG" id="ENOG502RCKM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100321_1_0_1"/>
    <dbReference type="InParanoid" id="W4JY10"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW77761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="167" mass="18735" checksum="36DA72A52D14118C" modified="2014-03-19" version="1" fragment="single">SPTESEFSRLDLLSDYVSVASSNSPPYLVSKLEAMLYYSGISPTPPKLVYRTGSLKTPWVKPTGSDSYRKLKQARGVFGHRLNVVWKDVGPVVRDLLNARKVAWTSIDVVRFITDGDIDEKTRGPVVLWIGVHPDSLQAEDAFSLSNDVFDLLAKFDIDNVEVEYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4JY55</accession>
    <name>W4JY55_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_325893</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550039.1">
        <property type="nucleotide sequence ID" value="XM_009551744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JY55"/>
    <dbReference type="STRING" id="747525.W4JY55"/>
    <dbReference type="GeneID" id="20671185"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_325893"/>
    <dbReference type="eggNOG" id="ENOG502S05E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019364_3_0_1"/>
    <dbReference type="InParanoid" id="W4JY55"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="184"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW78035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="489" mass="54913" checksum="D623A5532AF1D57A" modified="2014-03-19" version="1">MYDRHPVYPHQQHLPWAHEPWKTLYVLQRILSTLILVPCWIVYYTSLPRSYRPRPSWSLTQIVLVKFMKRIYRVTEVAGVTWNTRDPKAEPNGSTLRETRFAWVPPLPEQLRTGIVDDEEVSCQQVGTYIWPKEIPPRMYMRCAERGKFIDTAPSLQNVKHAKLSHPSGTEVEAESSNSRVIGVFLHGGGYCHMSAHEKSGTSRIPRRLMKDKLFEEIHAVEYRLLQHAPIPGAIQDAAAVYAYLVTHHLGAQRGVDGVVLIGDSAGGNLVLALARWIRDEGVLPSPDGMLLLSPSCDPSHTLPQVPASRRPRPHASTDYLLDTPEPRAVLQRAFLGHHPVAMVYSPYVSPASECVLAAFHGRVGMEELEPARAQHGEDGTRDYRENTGTDAESGMPADYANPYIYAPNGQGLFTSFPRALVVAGDAERLEREVVALAKGMEHDGVRVQMVWAPDGVHDILMLKSWDERVREDVWQAIGQWVAEVAREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYF1</accession>
    <name>W4JYF1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_454170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550134.1">
        <property type="nucleotide sequence ID" value="XM_009551839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYF1"/>
    <dbReference type="GeneID" id="20676472"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_454170"/>
    <dbReference type="HOGENOM" id="CLU_1366406_0_0_1"/>
    <dbReference type="InParanoid" id="W4JYF1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="200" mass="21841" checksum="4532D5AA2752408B" modified="2014-03-19" version="1">MPSPRGEGEEEGGMVEAVERPWPSTTDKLNVPGTRALARALSHASCARHRRHLQQRSTRVLRQTRACAVILRHPRPLRTRRLRPAPRHGPPSAAALLAEPQYAPLRARPCIHTAPVDPTPRLLIPIKAVLAPLRTDAIPSRWAPAVPSFVPSSLRLASSHLGLSAPTDAPAARDALVRFTPPGLPCPEWRARPKRPPHPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYF9</accession>
    <name>W4JYF9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_419862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548936.1">
        <property type="nucleotide sequence ID" value="XM_009550641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYF9"/>
    <dbReference type="GeneID" id="20673608"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_419862"/>
    <dbReference type="HOGENOM" id="CLU_1835419_0_0_1"/>
    <dbReference type="InParanoid" id="W4JYF9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="140" mass="15773" checksum="6136D13D6CEF851B" modified="2014-03-19" version="1">MIVVERARSRPGIPEALHARQAQACDRLTRIHLDSQRENVMRMYTACYVRRARQARLLSLCSSNVVLNDICMSAHLCDTWLLRSFRGCSNMLPIHIRLPSDVVDNAVPSTPHPMLPANSRRPLYMPASLPLMLASEIVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZ17</accession>
    <name>W4JZ17_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_479489</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550294.1">
        <property type="nucleotide sequence ID" value="XM_009551999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZ17"/>
    <dbReference type="GeneID" id="20677871"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_479489"/>
    <dbReference type="HOGENOM" id="CLU_035919_0_0_1"/>
    <dbReference type="InParanoid" id="W4JZ17"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="320"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW78315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="411" mass="45393" checksum="4DF0CB94E0B3B479" modified="2014-03-19" version="1">MTPPPDYLPTSAELVNTLRTPTPYFRPSYQASSQSWPPLHVPSTSTDSHWMPLASTGAQSFLSQFAAPTFANAPSSGPLSPPIWYSQGPYTHPSLAPPVQMPTPDVSSVGPSRVRRPHKRLQPYYRDEGNYAPPTSLPGFLVAGPSSQFQEPPVAGPSRPRQPRHRHRSPPAPSLPPPSPYPSNPHQSYPSPPFPTPPLLCTPPSPINPLAFNRAQKRKRQRADDEDEDEVQRPRRRKQGPSRPEQISATCQVGCAPHGVQPPQHITFANDEPEEDLRPQAAPKRVNRRVVGPRKASTSSTPAPKRNQPKGKPEAVKNRYPCPIAGCPCDFTSTSDMKRHVGTARSHQGFRDGADWPAFITEHALQDCHLLHYCDICDVERKASMRLDALIRHRRDSQNHLDKVAASGQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZS8</accession>
    <name>W4JZS8_HETIT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_441161</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009551028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZS8"/>
    <dbReference type="GeneID" id="20675333"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_441161"/>
    <dbReference type="HOGENOM" id="CLU_2004227_0_0_1"/>
    <dbReference type="InParanoid" id="W4JZS8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="124" mass="13949" checksum="AD3C52529E21F108" modified="2014-03-19" version="1">MMLLVFCHEGCLICWPLFTHVIYCAFLVDERLCLVNACARSIAAVYIFPMAAYNRFSLSMDLIHLGGLAITVILWALPRNRIGAVKIAVGRDVCGFGDEHRTWDQPTGLGESIRGHSTRLRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZU1</accession>
    <name>W4JZU1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Survival Motor Neuron Gemin2-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_165537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009552043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZU1"/>
    <dbReference type="STRING" id="747525.W4JZU1"/>
    <dbReference type="GeneID" id="20667992"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_165537"/>
    <dbReference type="eggNOG" id="ENOG502SY9H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081907_0_0_1"/>
    <dbReference type="InParanoid" id="W4JZU1"/>
    <dbReference type="OrthoDB" id="197400at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22852">
        <property type="entry name" value="SMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22851">
        <property type="entry name" value="SMN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047313">
        <property type="entry name" value="SMN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049481">
        <property type="entry name" value="SMN_G2-BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20636">
        <property type="entry name" value="SMN_G2-BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival Motor Neuron Gemin2-binding" evidence="2">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW78361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="296" mass="32797" checksum="24581A060F602AF4" modified="2014-03-19" version="1">MSKRPIVSYDDIVPTNSPHAGPSVTPQQQERSSAGPYPKKRKRSNPRNGRQYGRGAEPQRHVQHWDDPGSAVQPMPYDDESSISMTTQVILEPEDEGQEEANEEEEGEESRELTHDEIWDDSALIEAWESAAAEYEAFHGTDQSWKNEPVKKSPLWYNIPPPPSKLKKSPQKSETNVAPGVDADDSQPINFEGFVPHHDASLTSSSAIIPRVPSIDGHQLATAPEGFVSQDEAFNRALGAMYWAGYWTAVYHGHKKQPGASAPSNEGEEEDKDQEPGEADDVDDATVEEELISTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4K029</accession>
    <name>W4K029_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_104466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="129" mass="14140" checksum="4C9278CC3C800421" modified="2014-03-19" version="1">MPANARFKKPGLELLPHNPSTVDTRPSMPFMSSPTLTPSPLIQAIKELNPGRIFPNIVVDVSMFDVDRRAEARTAYDGTRSALLVMTKTSKFVAIALLHARASSAFGPYHHRSLTSSSFLITPSSHLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0J4</accession>
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        </submittedName>
    </protein>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="20676419"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_453771"/>
    <dbReference type="eggNOG" id="ENOG502SQQ4">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_480628_0_0_1"/>
    <dbReference type="InParanoid" id="W4K0J4"/>
    <dbReference type="OrthoDB" id="3270311at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844011" evidence="2">
        <location>
            <begin position="19"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW79333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="567" mass="62104" checksum="39815EDE888D98A2" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0R8</accession>
    <name>W4K0R8_HETIT</name>
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        <recommendedName>
            <fullName evidence="4">Glucose-6-phosphate isomerase</fullName>
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        </recommendedName>
    </protein>
    <gene>
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    </gene>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
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                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 4">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GPI family.</text>
    </comment>
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    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549620.1">
        <property type="nucleotide sequence ID" value="XM_009551325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0R8"/>
    <dbReference type="STRING" id="747525.W4K0R8"/>
    <dbReference type="GeneID" id="20676435"/>
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    <dbReference type="eggNOG" id="KOG2446">
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    </dbReference>
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    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW79387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="354" mass="39612" checksum="FF2F171B85E64985" modified="2014-03-19" version="1">MSAKLTSGAILPDLAHEKDQLILNDLFAADLSHFSRFSKEYTAASDPTNNFLLDYSKSRITQPIFVTLFNLIRKASVEQVHGKVFIAPPPRRKALCCPLRTKEKVVNVFDIAKENMFGFWDWVGGCYSFWSAIGLSITLVIGYEHYEARLCGAHDIDAHFLTAPLEKNLPVLLAVIGLWYNNLRTDVRAAPYDQHTHKCADYLHSCDMKSSGKVITKGSKRVDYQTILVIWSVASTNGQHSFYQLLHQGTNIVPADFLAPGMSHNPLRGSLHRRILLSNYFVQSKALVFGKTEEQVCREVGSGANEALMKSKVVEGSRPSNSIFFPLLRPATLAHRSLRAQDLHTGHHLGHQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4K105</accession>
    <name>W4K105_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_410291</name>
    </gene>
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        <lineage>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547981.1">
        <property type="nucleotide sequence ID" value="XM_009549686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K105"/>
    <dbReference type="GeneID" id="20672851"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_410291"/>
    <dbReference type="HOGENOM" id="CLU_2564623_0_0_1"/>
    <dbReference type="InParanoid" id="W4K105"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="82" mass="9121" checksum="9E6D628A9BB73A29" modified="2014-03-19" version="1" fragment="single">MVKRVPSGAVDPKEIGGVKPGYPPHYIRSNMQRALPDDRRACTTRRPSYFHLGDRKHGGAGVQKGTRRVIGVRKAVPRFTNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4K134</accession>
    <name>W4K134_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_18173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547901.1">
        <property type="nucleotide sequence ID" value="XM_009549606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K134"/>
    <dbReference type="GeneID" id="20668610"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_18173"/>
    <dbReference type="HOGENOM" id="CLU_2365243_0_0_1"/>
    <dbReference type="InParanoid" id="W4K134"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="96" mass="10885" checksum="BBE395EB4929BB9F" modified="2014-03-19" version="1" fragment="single">DALSRCPDLKEGVKSDNKDQVILQPQIFVQSATGQGTVEMLDSQLRQKLKEVTAKDREVTEAMELIKASGPRALSKGLQEWNYEDNIIWHRGKIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4K146</accession>
    <name>W4K146_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_419235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548118.1">
        <property type="nucleotide sequence ID" value="XM_009549823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K146"/>
    <dbReference type="STRING" id="747525.W4K146"/>
    <dbReference type="GeneID" id="20673550"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_419235"/>
    <dbReference type="eggNOG" id="ENOG502SYFS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_400644_0_0_1"/>
    <dbReference type="InParanoid" id="W4K146"/>
    <dbReference type="OrthoDB" id="3256305at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="687" mass="74943" checksum="278BCDEC990C6F74" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1B1</accession>
    <name>W4K1B1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">enoyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="11">1.3.1.104</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_323520</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.104"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.104" evidence="11"/>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549159.1">
        <property type="nucleotide sequence ID" value="XM_009550864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1B1"/>
    <dbReference type="FunCoup" id="W4K1B1">
        <property type="interactions" value="311"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K1B1"/>
    <dbReference type="GeneID" id="20670969"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_323520"/>
    <dbReference type="eggNOG" id="KOG0025">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_17_0_1"/>
    <dbReference type="InParanoid" id="W4K1B1"/>
    <dbReference type="OrthoDB" id="7482721at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000112">
        <property type="entry name" value="Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="38"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW78866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="346" mass="38397" checksum="4217D6ED8AA24ACE" modified="2014-03-19" version="1">MFPALYRPIRSVFRSFHTYHRLQTNRAIIYSRTGPPPEVISVLSYPSLPPPSPGTLNLRFVLSPINPSDINVIEGVYPLKPPPSHLSLITPHTFIAGNEGLAEVRGVGEGVYSFSDGDWVVLTKQQGGTWNTAVNVDALDVVKIPRKSNLTEVNAATMTVRIHKVNHPTAYNMLKDFVDLIPGDWVVQNGANSAVGQSVIQIAKARGLKTLNLIRNRDDISELKQELTDLGATCVATYDELADKSMKSKIKEWTDGKDIRLALNCIGGQPASDMARLLGRDAHLVSYGAMSKQPLSLPTSLFLFKNLTSHGFWQSRWYQQHSRDDRENLIKTLVDLMNDGKVSVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1C8</accession>
    <name>W4K1C8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_478531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549406.1">
        <property type="nucleotide sequence ID" value="XM_009551111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1C8"/>
    <dbReference type="GeneID" id="20677825"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_478531"/>
    <dbReference type="HOGENOM" id="CLU_1759049_0_0_1"/>
    <dbReference type="InParanoid" id="W4K1C8"/>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="148" mass="17311" checksum="B022137D40144448" modified="2014-03-19" version="1">MLYSQSLTTGDGGERGMGARNLRTDVRAYVRACPHIYIYETRRDRTERRDTRADRQNERKKRKKERQMDRWTGRQMDRDRDREAKSGRAKTSEYRRAYNLGATAAATSTWRRRRIAKEGRKERKEEGCECASTDEKREGGRGASGDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1G9</accession>
    <name>W4K1G9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Meiotically up-regulated protein Msb1/Mug8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_247075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548236.1">
        <property type="nucleotide sequence ID" value="XM_009549941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1G9"/>
    <dbReference type="STRING" id="747525.W4K1G9"/>
    <dbReference type="GeneID" id="20669141"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_247075"/>
    <dbReference type="eggNOG" id="ENOG502S5FF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126336_0_0_1"/>
    <dbReference type="InParanoid" id="W4K1G9"/>
    <dbReference type="OrthoDB" id="3362494at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037508">
        <property type="entry name" value="Msb1/Mug8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012965">
        <property type="entry name" value="Msb1/Mug8_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093:SF1">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08101">
        <property type="entry name" value="Msb1-Mug8_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meiotically up-regulated protein Msb1/Mug8" evidence="2">
        <location>
            <begin position="3"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW79673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="184" mass="20828" checksum="CC7EC149358083DD" modified="2014-03-19" version="1" fragment="single">RSASYPPLAFSQTLVPQLPPAHSELLFTTLDVISSLAAHSEANGISGSKLTKFMGLWLLTGRRSAEADDWKTFYDRWERAGRILEHLFLSRIRDEAVSNKMPKRLTELTDSYPYGQGSSSSDDDLLPRPRFSTRRYDALYVRLETEYTGVTKPKSHPLRLIAEALKSKGPEEGDQTLVWDAIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1J4</accession>
    <name>W4K1J4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">DNA polymerase</fullName>
            <ecNumber evidence="21">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">HETIRDRAFT_155985</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Catalytic component of DNA polymerase delta (DNA polymerase III) which participates in chromosomal DNA replication. Required during synthesis of the lagging DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork. Participates in leading strand synthesis during replication initiation and termination. Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 21">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 21">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 21">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="21"/>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549240.1">
        <property type="nucleotide sequence ID" value="XM_009550945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1J4"/>
    <dbReference type="FunCoup" id="W4K1J4">
        <property type="interactions" value="553"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K1J4"/>
    <dbReference type="GeneID" id="20667612"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_155985"/>
    <dbReference type="eggNOG" id="KOG0969">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000203_2_0_1"/>
    <dbReference type="InParanoid" id="W4K1J4"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05777">
        <property type="entry name" value="DNA_polB_delta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05533">
        <property type="entry name" value="POLBc_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.730:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 21" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 21" id="KW-0235">DNA replication</keyword>
    <keyword evidence="17 21" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14 21" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 21" id="KW-0408">Iron</keyword>
    <keyword evidence="16 21" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 21" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18 21" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 21" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 21" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="23">
        <location>
            <begin position="125"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="22">
        <location>
            <begin position="424"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="24">
        <location>
            <begin position="892"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00055225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="ETW78956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="989" mass="111598" checksum="F6BD4AD90B2333A3" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1T2</accession>
    <name>W4K1T2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_478702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549530.1">
        <property type="nucleotide sequence ID" value="XM_009551235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1T2"/>
    <dbReference type="STRING" id="747525.W4K1T2"/>
    <dbReference type="GeneID" id="20677836"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_478702"/>
    <dbReference type="eggNOG" id="KOG2401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1938690_0_0_1"/>
    <dbReference type="InParanoid" id="W4K1T2"/>
    <dbReference type="OrthoDB" id="3231855at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052772">
        <property type="entry name" value="Endo/PolyKinase_Domain-Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535:SF1">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="1">
        <location>
            <begin position="71"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="149" mass="16038" checksum="8BE6850D46F499C8" modified="2014-03-19" version="1">MEELRVRRAEAILSAGRAWQKGNTKNKGGEVAMFYAEQARELQEQVRKEALVAARSRVEAKTVTTAVGTTVDLHGTTVAEAITIAKEVLTEHGATSAQPIKFITGRGNHSVNRVGVLAPAIKMALLEDGWNVSTFDAGIVVRGRAFGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2E7</accession>
    <name>W4K2E7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_48850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547930.1">
        <property type="nucleotide sequence ID" value="XM_009549635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2E7"/>
    <dbReference type="STRING" id="747525.W4K2E7"/>
    <dbReference type="GeneID" id="20678088"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_48850"/>
    <dbReference type="eggNOG" id="KOG4205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_1_5_1"/>
    <dbReference type="InParanoid" id="W4K2E7"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000025">
        <property type="entry name" value="RNA-binding protein Musashi homolog 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF6">
        <property type="entry name" value="RNA-BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="83"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW79894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="132" mass="14759" checksum="94695219A74F9ABE" modified="2014-03-19" version="1" fragment="single">KMFVGGLSWDTTDEGLRNYFSEFGKVDACTIVRDPDGKSRGFAFLTFDDPASVNSVMIREHFLDGKAIDPKRAIPREEHLRNTRYFVGGLAPHTTSDSMRGFFSSFGKVVDATVMVDRETGRSKGFGFVTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2W2</accession>
    <name>W4K2W2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_322514</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548679.1">
        <property type="nucleotide sequence ID" value="XM_009550384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2W2"/>
    <dbReference type="GeneID" id="20670865"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_322514"/>
    <dbReference type="HOGENOM" id="CLU_2306504_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2W2"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW80163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="100" mass="11081" checksum="F07F7239E444515F" modified="2014-03-19" version="1">MPKTLTLSLRKSAGSLVGKSSFDKPGTITLYDNHMSSAETKHYELEGAIAGHNVQDIPGRVIVQRPWIAMSQSTRVYCSITRRVTWYVCGMNGWAGLDVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2Z6</accession>
    <name>W4K2Z6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_452630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548018.1">
        <property type="nucleotide sequence ID" value="XM_009549723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2Z6"/>
    <dbReference type="GeneID" id="20676280"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_452630"/>
    <dbReference type="HOGENOM" id="CLU_1896485_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2Z6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="134" mass="14138" checksum="38C844CEADD48D45" modified="2014-03-19" version="1">MESPSDDIKTQPRPTSDIPADLPSPDVPPHDTKDPISPDAVPSPAHTVDTPAAADADADAPAPSESRRSSSSLPPESHPTIAFLFSFPEPAHLPQKERHRLAVPPFVLYAPLAAALVKPAPGAKESVAHKAQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4K366</accession>
    <name>W4K366_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GMC oxidoreductase 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gor7</name>
        <name evidence="8" type="ORF">HETIRDRAFT_49580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547956.1">
        <property type="nucleotide sequence ID" value="XM_009549661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K366"/>
    <dbReference type="GeneID" id="20678114"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_49580"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_7_2_1"/>
    <dbReference type="InParanoid" id="W4K366"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF219">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="518"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="564"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW79511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="592" mass="66206" checksum="02846E34E4567909" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4K377</accession>
    <name>W4K377_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_440276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547042.1">
        <property type="nucleotide sequence ID" value="XM_009548747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K377"/>
    <dbReference type="GeneID" id="20675246"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_440276"/>
    <dbReference type="HOGENOM" id="CLU_1578720_0_0_1"/>
    <dbReference type="InParanoid" id="W4K377"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="169" mass="19407" checksum="407A36BCCD92D48A" modified="2014-03-19" version="1">MGSLELHDPSEVKSEKSPALPRRTMRRCPEPKFVVERRWTPGARRANAEMKSRFVHSGVARVCQRSGHKAHAGVLGLRACLIHACVKWGEGGGCSFVRAFSGNDIRNRERQATRQVTPLQLSPSLIHSIRPRYVEFGRFYQDCLRRHSRWCANHRHGLPFQHKSSRFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3F0</accession>
    <name>W4K3F0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Nucleobase cation symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_65247</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546990.1">
        <property type="nucleotide sequence ID" value="XM_009548695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3F0"/>
    <dbReference type="STRING" id="747525.W4K3F0"/>
    <dbReference type="GeneID" id="20678724"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_65247"/>
    <dbReference type="eggNOG" id="ENOG502QR29">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026016_2_1_1"/>
    <dbReference type="InParanoid" id="W4K3F0"/>
    <dbReference type="OrthoDB" id="2116389at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF1">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW80269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="528" mass="56544" checksum="39F65A8A8F056966" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3Z0</accession>
    <name>W4K3Z0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="8">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_169311</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="8"/>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547286.1">
        <property type="nucleotide sequence ID" value="XM_009548991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3Z0"/>
    <dbReference type="FunCoup" id="W4K3Z0">
        <property type="interactions" value="230"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K3Z0"/>
    <dbReference type="GeneID" id="20668213"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_169311"/>
    <dbReference type="eggNOG" id="KOG0581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_79_3_1"/>
    <dbReference type="InParanoid" id="W4K3Z0"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000341">
        <property type="entry name" value="MAP kinase kinase PBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF25">
        <property type="entry name" value="MAP KINASE KINASE PBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="221"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="99"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW80553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="517" mass="55464" checksum="6205D3CE89B4FCC8" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4C4</accession>
    <name>W4K4C4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_321678</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548432.1">
        <property type="nucleotide sequence ID" value="XM_009550137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4C4"/>
    <dbReference type="STRING" id="747525.W4K4C4"/>
    <dbReference type="GeneID" id="20670778"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_321678"/>
    <dbReference type="eggNOG" id="KOG0192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015983_0_0_1"/>
    <dbReference type="InParanoid" id="W4K4C4"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050940">
        <property type="entry name" value="Actin_reg-Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485:SF5">
        <property type="entry name" value="CENTER DIVIDER, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46485">
        <property type="entry name" value="LIM DOMAIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="14"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="12">
        <location>
            <begin position="498"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="543"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="564"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW79896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="577" mass="63328" checksum="697A3B27F2B6B75C" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4S3</accession>
    <name>W4K4S3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_319489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009548821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4S3"/>
    <dbReference type="GeneID" id="20670602"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_319489"/>
    <dbReference type="eggNOG" id="ENOG502RVG5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053011_0_0_1"/>
    <dbReference type="InParanoid" id="W4K4S3"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW80355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="326" mass="37323" checksum="1A8A7D62BD757B5F" modified="2014-03-19" version="1">MGYTHLTPEQREQFLQNGWIRIENGVPKENIERFLENIWVRLGFDPDDKATWLKEKIHMPRHREISTPEFMPKAWGAICELLGGEDRIDRTLFESCGDSLIVNLGCEEWENRDIEPKDLGNWHIDGDWFTHYLDSGEQALEVLILYNDIKPKAGATWIAPDGIKNAVRYLYDHPEGVDEFSQDPDGSRSVCSIQTCDQFVELTGKAGDVILMHPFMPHSASKNHLRIPRFITNPPVTLKAPFNLNRENPKEYSLIEQKILNTLGVESLPDWKITGARRRYTPRTRAGKDSMIIQEVERLKTHALRTGGVVDSMHINGPVPYQVIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5B3</accession>
    <name>W4K5B3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_12711</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546876.1">
        <property type="nucleotide sequence ID" value="XM_009548581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5B3"/>
    <dbReference type="STRING" id="747525.W4K5B3"/>
    <dbReference type="GeneID" id="20666973"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_12711"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_5_1"/>
    <dbReference type="InParanoid" id="W4K5B3"/>
    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW80934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="387" mass="41966" checksum="00FB6D4FA5D1C970" modified="2014-03-19" version="1" fragment="single">KVIVVGAGIAGPILAIFLKLRGYEPVLYERLEGVQQAGLSLMLQPNGLRVLSQIPGFVQTIPGKAIERMVFCSTVEEDLGVLGESYIPSRLPSAYGHGMFGVQRIAFHRAIVDAAVAHGIQIHWGHTLVSLEQSEDHVKVVFENGSDDTGSFVVGCDGLHSGTRIALFGKEKADFTGLCQTGGLSPTPEVLKAHASHTNWFGNAAHMVAYPISDTHTSWAVTTREAESKETWGTVNIQTAQDFMRSPVSNWGQGAGELVKTTERVIKYGLYDRPELRSWFKGRVVLLGDAAHPTSPHLGQGANQAFEDVQKLISLLDQHNTERTSPTTPTLDTVFRAFESARIPRCAALVKGARQEGEGRVVEGVEACLKRNLAVRDATKDDGALYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6B2</accession>
    <name>W4K6B2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-methylcitrate dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_452365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547580.1">
        <property type="nucleotide sequence ID" value="XM_009549285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6B2"/>
    <dbReference type="GeneID" id="20676249"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_452365"/>
    <dbReference type="eggNOG" id="ENOG502QPZI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021803_1_0_1"/>
    <dbReference type="InParanoid" id="W4K6B2"/>
    <dbReference type="OrthoDB" id="10055203at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047547">
        <property type="term" value="F:2-methylcitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.120:FF:000001">
        <property type="entry name" value="2-methylcitrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012705">
        <property type="entry name" value="2Me_IsoCit_deHydtase_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006943">
        <property type="entry name" value="PRK09425.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02330">
        <property type="entry name" value="prpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF16">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="3">
        <location>
            <begin position="19"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="4">
        <location>
            <begin position="284"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW80885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="53417" checksum="545671916E9FE1D1" modified="2014-03-19" version="1">MSTSFGESTVRPEPDQVVQDIADYVHSYKIDSELAFETARLCLIDTIGCGLEGLRFPECSRLLGPVVEGTVVPNGTRVPGTNYQLDPIRGAFNIGTIIRWLDFNDCFLAAEWGHPSDNLGAILAVADHLARTGQKVTVRDVLEGMIKAHEIQGGLALLNSFNRVGLDHVVLVKVASTAVVSKLLGLSREQTIDAISQAWADGQSLRTYRHAPNTGSRKSWAAGDACSRAVNLAYLVKKGEIGMPSVLTAKTWGFYDVLFKGKPFEFQRPYGSYVMENVLFKISYPAEFHAQTAVEAAYIVHDKLKALGKTAEDIKSVRIRTQEAAIRIIDKQGPLDNFADRDHAISYMVAYPLIHGELTSQSYTDASASDPRIDVLRAKTFCVEDKRFSVDYHDPEKRSIGNALLVELNDGTVLDEVEVEYPVGHKRRREEGTPLLLAKFRRHIGYHFDETHQKKIIDTMSDAKALGELSADKFTDLFVKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6E5</accession>
    <name>W4K6E5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_318084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545978.1">
        <property type="nucleotide sequence ID" value="XM_009547683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6E5"/>
    <dbReference type="GeneID" id="20670473"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_318084"/>
    <dbReference type="HOGENOM" id="CLU_115504_0_0_1"/>
    <dbReference type="InParanoid" id="W4K6E5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="207" mass="23762" checksum="C653EFACF2A7FD63" modified="2014-03-19" version="1">METQRHPNIAISPETGSTPKHGKLSRSRPLSVEERIAIIFKCVPKELRPRFSLSDHFYSMEEVASAPPLLSLPRALIPKRGRETPPYLHYGLPISLEKMTSLARSREPTVEIIIKLGFVSLTVRQLAAKCLSEEIGWPVYLERVLNAPNTPFAVCLIENHTVEERQKTNEFPTRDHIRRMQKALEVGPEARPLWYIAAGFYTWQYHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6R1</accession>
    <name>W4K6R1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_474849</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546076.1">
        <property type="nucleotide sequence ID" value="XM_009547781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6R1"/>
    <dbReference type="STRING" id="747525.W4K6R1"/>
    <dbReference type="GeneID" id="20677587"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_474849"/>
    <dbReference type="eggNOG" id="ENOG502QU1B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018354_4_0_1"/>
    <dbReference type="InParanoid" id="W4K6R1"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844044" description="FAD-binding PCMH-type domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="121"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW81429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="568" mass="62074" checksum="93A2A2A51DC095A8" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6R7</accession>
    <name>W4K6R7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_318087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546164.1">
        <property type="nucleotide sequence ID" value="XM_009547869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6R7"/>
    <dbReference type="STRING" id="747525.W4K6R7"/>
    <dbReference type="GeneID" id="20670474"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_318087"/>
    <dbReference type="HOGENOM" id="CLU_777459_0_0_1"/>
    <dbReference type="InParanoid" id="W4K6R7"/>
    <dbReference type="OrthoDB" id="3365698at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="357" mass="40961" checksum="F404B566D6206431" modified="2014-03-19" version="1" fragment="single">MPTTTVHPNRYTSALVPYHIGKLPIEMLEQVFIECARDTIYPSNIEMLTVGDYNTAPDWINITYVCRLWRRISLVCPYLWTHITTNLSHRWVLEFLKRSRKHPLVLELSTFHSTFRDIKLVLYAHAFRVRQLYLGDVVVSNPVMLSELGSGLTVSAPLLEDLVLEVGQCEVQDDLFSGYAPRLHRLGLGDAMTISIDSPLLGHLRELEVRETYDADGLLKLLQNTPLLESLKVSDLVPGRQYSGVDVHLPHLSALCIRLYDYRSFLSFFERLRIPPTVHFQIILCILRVSSTEEEYCAVLDVIADRVRGISKSIGPLCASLEIEPEKDWCIAWYPIRQTLDDPAVDRTPRRALREYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6U1</accession>
    <name>W4K6U1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aspartic peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_64844</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545892.1">
        <property type="nucleotide sequence ID" value="XM_009547597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6U1"/>
    <dbReference type="GeneID" id="20678704"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_64844"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_8_0_1"/>
    <dbReference type="InParanoid" id="W4K6U1"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF73">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844328" evidence="6">
        <location>
            <begin position="23"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="457"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="56"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="420"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="501"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="424"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW81523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="533" mass="56324" checksum="1AFD44D52B95CE22" modified="2014-03-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6X8</accession>
    <name>W4K6X8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein artemis</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DNA cross-link repair 1C protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HETIRDRAFT_173177</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546145.1">
        <property type="nucleotide sequence ID" value="XM_009547850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6X8"/>
    <dbReference type="STRING" id="747525.W4K6X8"/>
    <dbReference type="GeneID" id="20668426"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_173177"/>
    <dbReference type="eggNOG" id="KOG1361">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_315937_0_0_1"/>
    <dbReference type="InParanoid" id="W4K6X8"/>
    <dbReference type="OrthoDB" id="5561659at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF8">
        <property type="entry name" value="PROTEIN ARTEMIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="14">
        <location>
            <begin position="306"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="534"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="576"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="814"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="540"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="606"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="678"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="713"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="734"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="762"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="826"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETW81504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="924" mass="102490" checksum="16F102DDB8C4D446" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4K724</accession>
    <name>W4K724_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TRX family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TRX9</name>
        <name evidence="7" type="ORF">HETIRDRAFT_64872</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545894.1">
        <property type="nucleotide sequence ID" value="XM_009547599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K724"/>
    <dbReference type="STRING" id="747525.W4K724"/>
    <dbReference type="GeneID" id="20678706"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_64872"/>
    <dbReference type="eggNOG" id="KOG0324">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033441_0_0_1"/>
    <dbReference type="InParanoid" id="W4K724"/>
    <dbReference type="OrthoDB" id="21221at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070646">
        <property type="term" value="P:protein modification by small protein removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF7">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="6">
        <location>
            <begin position="2"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="172"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="5">
        <location>
            <begin position="327"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW81554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="634" mass="68787" checksum="1ADA2F97D308E2E7" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4K770</accession>
    <name>W4K770_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_319487</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547591.1">
        <property type="nucleotide sequence ID" value="XM_009549296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K770"/>
    <dbReference type="FunCoup" id="W4K770">
        <property type="interactions" value="336"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K770"/>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_319487"/>
    <dbReference type="eggNOG" id="KOG0667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_5_15_1"/>
    <dbReference type="InParanoid" id="W4K770"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14212">
        <property type="entry name" value="PKc_YAK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000087">
        <property type="entry name" value="Dual specificity tyrosine-phosphorylation-regulated kinase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000380">
        <property type="entry name" value="Serine/threonine-protein kinase ppk15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF17">
        <property type="entry name" value="HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="111"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW80896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="486" mass="55818" checksum="B3B6890F838BEF53" modified="2014-03-19" version="1" fragment="single">MAVDPPAKRRASGFRRIRDQRDLRPHVNQRPAGRRVDASGAFLSPLRQLTTNIVDTYRIANPAFKYESTHNPRRVLTKPSKAMHNDGYDNEDYDYILYVNDWLGAEETHKYLILDVLGQGTFGQVVKCQDLKTHDVVAVKVVKNKPAYFNQSMMEVTILELLNNQCDPHDEHHILRLRDSFIHRNHLCLVFELLSSNLYELIKQNQFQGLSTQLVKVFTAQLLDALSVLKDARLIHCDLKPENILLKSLQSPQIKVIDFGSACHERQTVYTYIQSRFYRSPEVLLGLPYTAAIDMWSLGCIAVELFLGLPLFPGTSEYNQVTRIVEMLGCPPSYMMDMGKQTGQFFDTFHDMYGRKKYRLKTLEQYSREHGTNEQPGKQYFKATSLPEIVNGAPMPTFKSGRQGPEMDKELNNRASFIDFCSGLLNMNPIERWSPQQARMHPFITGEKYTKPYLNPNPPANTYYPSTRMRANTINNMDNVPPALAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7A7</accession>
    <name>W4K7A7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_475188</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546331.1">
        <property type="nucleotide sequence ID" value="XM_009548036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7A7"/>
    <dbReference type="STRING" id="747525.W4K7A7"/>
    <dbReference type="GeneID" id="20677609"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_475188"/>
    <dbReference type="eggNOG" id="KOG2655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031563_0_0_1"/>
    <dbReference type="InParanoid" id="W4K7A7"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="166"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="412"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="539"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="692"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="576"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="700"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW81717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="711" mass="76597" checksum="99BE6B75647C6D67" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4K862</accession>
    <name>W4K862_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein uL23 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_384460</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546599.1">
        <property type="nucleotide sequence ID" value="XM_009548304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K862"/>
    <dbReference type="FunCoup" id="W4K862">
        <property type="interactions" value="325"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K862"/>
    <dbReference type="GeneID" id="20672204"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_384460"/>
    <dbReference type="eggNOG" id="KOG1751">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037562_0_2_1"/>
    <dbReference type="InParanoid" id="W4K862"/>
    <dbReference type="OrthoDB" id="1267328at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000035">
        <property type="entry name" value="60S ribosomal protein L23a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_uL23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_uL23_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005633">
        <property type="entry name" value="Ribosomal_uL23_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011118">
        <property type="entry name" value="PRK14548.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L23A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03939">
        <property type="entry name" value="Ribosomal_L23eN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL23 N-terminal" evidence="8">
        <location>
            <begin position="23"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW82017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="161" mass="18089" checksum="131E1C7AAA25F275" modified="2014-03-19" version="1">MAATKSTKGKTAPKTTKTAASKDAKAKSAKKAALQGVHGHHSRKVRHTVSFHRPKTLRLPRDPKYQRKSVHHAPRMDEFRTIVSPLNTESAMKKIEEHNTLVFIVDIKSNKRQIKDAVKKLWDVQAAKINTLIRPDGKKKAYVRLTADHDALDVANKIGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9J4</accession>
    <name>W4K9J4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_450354</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544865.1">
        <property type="nucleotide sequence ID" value="XM_009546570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9J4"/>
    <dbReference type="STRING" id="747525.W4K9J4"/>
    <dbReference type="GeneID" id="20676033"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_450354"/>
    <dbReference type="HOGENOM" id="CLU_1434604_0_0_1"/>
    <dbReference type="InParanoid" id="W4K9J4"/>
    <dbReference type="OrthoDB" id="2630497at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="29"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW82507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="189" mass="21597" checksum="C918AEAC6101E7C8" modified="2014-03-19" version="1">MLTPYKETEAHGKNFARPLPEVLNDEEHYEVEEIVDSKKQGWGTKYLVKWMGYPEADDTWEPYTLLKGMAEEAMKKLHDRYPNKPPIPWPLPLTGYETFPYPRGVPTRRNRLSIEGTKEEGVEEPKQPSNMEQLLAGVFDTGLERLLLVLDFVRTRDRITGVAAELATLIWRLEKIALGLGLSSTPGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9Y8</accession>
    <name>W4K9Y8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit I</fullName>
            <shortName evidence="7">eIF3i</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 39 kDa subunit homolog</fullName>
            <shortName evidence="7">eIF-3 39 kDa subunit homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TIF34</name>
        <name evidence="9" type="ORF">HETIRDRAFT_147751</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit I family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546467.1">
        <property type="nucleotide sequence ID" value="XM_009548172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9Y8"/>
    <dbReference type="FunCoup" id="W4K9Y8">
        <property type="interactions" value="538"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K9Y8"/>
    <dbReference type="GeneID" id="20667224"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_147751"/>
    <dbReference type="eggNOG" id="KOG0643">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043845_0_1_1"/>
    <dbReference type="InParanoid" id="W4K9Y8"/>
    <dbReference type="OrthoDB" id="24966at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000127">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03008">
        <property type="entry name" value="eIF3i"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027525">
        <property type="entry name" value="eIF3i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF1">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24805">
        <property type="entry name" value="EIF3I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="6"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="48"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="187"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW81876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="334" mass="37237" checksum="66F95373B7F198FA" modified="2014-03-19" version="1">MRPILLQGHERSLTQIKFNREGDLLFSASKDLIINVWFSHNGERLGTYEGHNGSVWTIDVDSQSRFLVSGAADNEMRLWSVQTGKCLFVWEFPTAVKRVAFNENDDQVVCITEQRMGYQGAIRVFDINREGDGTNQSKEPASIFHPIGSKATVCAFSYIPNLIITGHESGKVALFDAKSGEEVLNNERAHMDVVTDLQLSSDRTYFITSSKDKTARIHDAKTLTVLKTFSTETPLNSATLAPKMPYVLLGGGQEAMSVTTTSLRQGKFETRFWHQVFEEEVGRVKGHFGPINTIAVHPAGTAYASGGEDGFVRVHQYDESYFKAKPYGDIEILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9Z8</accession>
    <name>W4K9Z8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Checkpoint protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_57794</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the HUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544678.1">
        <property type="nucleotide sequence ID" value="XM_009546383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9Z8"/>
    <dbReference type="FunCoup" id="W4K9Z8">
        <property type="interactions" value="358"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K9Z8"/>
    <dbReference type="GeneID" id="20678407"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_57794"/>
    <dbReference type="eggNOG" id="KOG3999">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035754_2_0_1"/>
    <dbReference type="InParanoid" id="W4K9Z8"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044778">
        <property type="term" value="P:meiotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016580">
        <property type="entry name" value="HUS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007150">
        <property type="entry name" value="HUS1/Mec3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900:SF0">
        <property type="entry name" value="CHECKPOINT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900">
        <property type="entry name" value="MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04005">
        <property type="entry name" value="Hus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011312">
        <property type="entry name" value="Cell_cycle_HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW82603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="300" mass="32841" checksum="E972E385626D0D06" modified="2014-03-19" version="1">MRFRASIQNVATFRRIIQTVEKLQKKCIIKFNETEMHIICNTDESGVQVWSQIRTIALFTDYRIQSNADNQISLLLSTEALLHALRSSESSSNADDIVMKLAKKRDVAVLSFEILGAGTGAAAGAGASTGGGMKVTHDVRIEVLKPAEVERLREPLCPEPDIHILLPPLLKLRTLVDRLRPMADIVAVRANGAGRLQISAGTDEVKLDLVWEGCTNPRMDGHADVHDGDDADEDKSDPSQMYGVLVHVRSLLKFLNAHVVSTTTIACICHAHCMILYVYIGEVADAGGVLTFYIPAVLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KA16</accession>
    <name>W4KA16_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_108905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545018.1">
        <property type="nucleotide sequence ID" value="XM_009546723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KA16"/>
    <dbReference type="GeneID" id="20666393"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_108905"/>
    <dbReference type="eggNOG" id="ENOG502SRIE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003921_0_1_1"/>
    <dbReference type="InParanoid" id="W4KA16"/>
    <dbReference type="OrthoDB" id="5596707at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW82682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="41913" checksum="B19D02424794FC82" modified="2014-03-19" version="1">MFERLTDTFVKAIAAQGTSRPADRPSRQPGQGGNNCMFCGSPEHFMRACPEVTEYIRIGKCKRNIEGKVVLSSGAFESRTVGDWTDDVHGKRGADSPDDDSLPSRFTLAAGLPAKDDAPIHPYAKAQDATYAPPHERNIGAPAKIPSAKKDAPAYKTTAPIYDEKVAAEVYNRAMATQVTLTQRELLSLSTKVRSQVREATSARRSPARDASNVRTFYQDADLPYAIDDLEPPTRPTVSSFVNVLHQPETPPPGATIIPDMYETSIVPLVDHQQEVECIIDLGSQVIAMSEGICNELSLIYDPEIVLNMQSANGEIDRSLGLARNVPFLIGDITLYLQVHIIRNPAYDVLLGRPFDILTESIVKNYSNEDQTITISDPNTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KA66</accession>
    <name>W4KA66_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_473832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545057.1">
        <property type="nucleotide sequence ID" value="XM_009546762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KA66"/>
    <dbReference type="GeneID" id="20677542"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_473832"/>
    <dbReference type="HOGENOM" id="CLU_491799_0_0_1"/>
    <dbReference type="InParanoid" id="W4KA66"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="554" mass="57900" checksum="879FD5549D42F375" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAE7</accession>
    <name>W4KAE7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Chitin synthase</fullName>
            <ecNumber evidence="2 12">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HETIRDRAFT_122804</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the chitin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 12"/>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546843.1">
        <property type="nucleotide sequence ID" value="XM_009548548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAE7"/>
    <dbReference type="FunCoup" id="W4KAE7">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KAE7"/>
    <dbReference type="GeneID" id="20666792"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_122804"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004760_3_1_1"/>
    <dbReference type="InParanoid" id="W4KAE7"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
        <property type="entry name" value="CHITIN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="649"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="689"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="719"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="763"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="899"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="932"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="14">
        <location>
            <begin position="207"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETW82315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="963" mass="107982" checksum="C636712B69F41DFC" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAH2</accession>
    <name>W4KAH2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_416875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545132.1">
        <property type="nucleotide sequence ID" value="XM_009546837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAH2"/>
    <dbReference type="STRING" id="747525.W4KAH2"/>
    <dbReference type="GeneID" id="20673367"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_416875"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_33_7_1"/>
    <dbReference type="InParanoid" id="W4KAH2"/>
    <dbReference type="OrthoDB" id="1750432at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="140" mass="16489" checksum="7B1553D8B285FDCC" modified="2014-03-19" version="1">MVVFFGLTNSLVTFQAMINMIFQKLIIAHKITIYMDDILIFSKSMAEHIHIFYQVFQILCDNDLYIKPEKHEFYKEKLNYLGYTISKDYITIKNSKVDTKKDWPIICMVQDICSFLGLGNFYRRTKNKIGLTNAKKPLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAL7</accession>
    <name>W4KAL7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribosomal L1 domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_317029</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the universal ribosomal protein uL1 family. Highly divergent.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546689.1">
        <property type="nucleotide sequence ID" value="XM_009548394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAL7"/>
    <dbReference type="FunCoup" id="W4KAL7">
        <property type="interactions" value="582"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KAL7"/>
    <dbReference type="GeneID" id="20670384"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_317029"/>
    <dbReference type="eggNOG" id="KOG1685">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026457_4_0_1"/>
    <dbReference type="InParanoid" id="W4KAL7"/>
    <dbReference type="OrthoDB" id="10251727at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000004">
        <property type="entry name" value="Ribosomal L1 domain-containing 1-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="252"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW82131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="363" mass="39863" checksum="7C14045646403276" modified="2014-03-19" version="1">MAKNELIDAHVSSRQCKRAVNALLTHAIKHQEQKQETELLAGKEQHVWLQVAVKRMHPEKKLKPFKIPLKYPLVDPRTSSVCLITKDPQREYKDLLDSHGIKFINRVVGITKLKGKFKPFEARRLLLQENGLFLADERVVPLLPGLLGRKFFDAKKQPIPVCLTRKDLKGELERAISSTYMHQNQGTCTSIKIGTLSQTPSQVLANLEIALPSVVKNIHDGWENVQSLSIKTNSSASLPIWSCELGAEDGGRWDGLVAGDESDESSSDEEGGEEAGDSDEDEAMQVDELKAPPILPPKEKSKGTKRVAEEGEGEKPKKKAKGEVSAGLPQSIPSPSLQLQKAVSSVSLEAISSISYMSALPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4KB42</accession>
    <name>W4KB42_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_149158</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544936.1">
        <property type="nucleotide sequence ID" value="XM_009546641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KB42"/>
    <dbReference type="STRING" id="747525.W4KB42"/>
    <dbReference type="GeneID" id="20667324"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_149158"/>
    <dbReference type="eggNOG" id="ENOG502SC5Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175718_0_0_1"/>
    <dbReference type="InParanoid" id="W4KB42"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033768">
        <property type="term" value="C:SUMO-targeted ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032183">
        <property type="term" value="F:SUMO binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140082">
        <property type="term" value="F:SUMO-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049627">
        <property type="entry name" value="SLX8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47094">
        <property type="entry name" value="ELFLESS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47094:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="35"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW82585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="107" mass="11144" checksum="1BFBCBC933B1DE3E" modified="2014-03-19" version="1">MHPASDLTTILPTHSLPISPLPRAPEPEPLHTYCCPICFSPPTNATLTPCGHILCGECLFTAVNAAVMRTGVGGLGARCPVCRATLPGWDGRGGGVIGLRARVMITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KB93</accession>
    <name>W4KB93_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_450790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545401.1">
        <property type="nucleotide sequence ID" value="XM_009547106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KB93"/>
    <dbReference type="STRING" id="747525.W4KB93"/>
    <dbReference type="GeneID" id="20676078"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_450790"/>
    <dbReference type="eggNOG" id="ENOG502R1EN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_852740_0_0_1"/>
    <dbReference type="InParanoid" id="W4KB93"/>
    <dbReference type="OrthoDB" id="3174319at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="326" mass="35890" checksum="187B61D9BA337B3A" modified="2014-03-19" version="1">MHLLLRGKQLWMAIELKHAIITGMTTIMFAVSTVHIGLSIEGFYENYLKTPKWSSGVGTDPSCITKLYLPAINFMLSDAIVTWRAYVLWGFNKKVCIVPCILVLATGVVAIIGVQQSAAHMATLQLTASYPWDLAMNCLTLATNVITTGLVTYRGRVALGSDASERSKAIFYLLIESGFLYCFTWVSPLLARPQRRHCPKTDSIQVVFFIVYWSGPQGNFLTTDMISQLTGIYSTLIVVLVALKKTQADSVGVDQTVTDTFDDSEIAVRHEHGTTTGSAVLTTTVSRAQGLSGRGQPVMIHITNTVERDRGDLKNITLVPQRLQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCC9</accession>
    <name>W4KCC9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA2/NAM7 helicase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_152688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545287.1">
        <property type="nucleotide sequence ID" value="XM_009546992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCC9"/>
    <dbReference type="STRING" id="747525.W4KCC9"/>
    <dbReference type="GeneID" id="20667417"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_152688"/>
    <dbReference type="eggNOG" id="KOG1802">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_754512_0_0_1"/>
    <dbReference type="InParanoid" id="W4KCC9"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="1">
        <location>
            <begin position="188"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="367" mass="41761" checksum="BD724B6715306974" modified="2014-03-19" version="1">MALGKNCDALKLWTHWGLQAARMWIPRHQTSAYLKLHRTMHAISGKAILLRPFDSGCSQGDRKPTVYMATLTQFNKTTFAGRHVRYFHLKTIHDMVTTIHNLSPPIPGTSVGLNDTGSITAVAFATENHISHICWEKRLQHVFHKFKKDQTKVSFFGDPKQRGCLIPPRGAEQAKLKIIPSSISSISETAYLLDTHYKTLITLRFLSKHVYDNKLRSERAIKRPSRIQFMDVCKGEERRSGSKSKNIEEVHTIVRLVKQYYNKTDFCVITPYAAQRAAISMQLKKENLRFDRVFNVDSFQGNEADYVIVSALPALEEPDKRMLTRCKKGMVIVTSRQFLRGGGGGKMLGLLVAEFEAKWRRPGRTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCE0</accession>
    <name>W4KCE0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_383456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545653.1">
        <property type="nucleotide sequence ID" value="XM_009547358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCE0"/>
    <dbReference type="STRING" id="747525.W4KCE0"/>
    <dbReference type="GeneID" id="20672157"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_383456"/>
    <dbReference type="eggNOG" id="KOG2793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039535_0_0_1"/>
    <dbReference type="InParanoid" id="W4KCE0"/>
    <dbReference type="OrthoDB" id="413520at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF161">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW83399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="322" mass="34858" checksum="B546FF4EC7668B24" modified="2014-03-19" version="1" fragment="single">MQGLSDTGHHQELMMANPNFPENLSISPSQHPQTILTAPVTAADPYVSHFAFDASAQAAAIEKYGIAGRVWEAAYLLTLYFNAPPSHAFDPPFDPHGASQLTVVELGSGTGIVGLKLAERLARTGTDSSNLVVLTDLPEVCPLLQENLQQHAALTERDVWVRALPWGSRAHADTLAEELGLRADPPSEARPRYPTHIVCSDLVYFPELLAPLLRTLLHLTSPPFVPVSASSLPSPPEVIVSYKIRSLAKETAFWSAFGLWFTFTPVLTSPSASTSPDLSWKRFGASVDAFILIAHRRPESMRWPVPEDDAGLLGGVGAHGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCE4</accession>
    <name>W4KCE4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase II assembly factor Rtp1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_313250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Tango6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543318.1">
        <property type="nucleotide sequence ID" value="XM_009545023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCE4"/>
    <dbReference type="GeneID" id="20670016"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_313250"/>
    <dbReference type="eggNOG" id="KOG4653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005991_0_0_1"/>
    <dbReference type="InParanoid" id="W4KCE4"/>
    <dbReference type="OrthoDB" id="39591at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019451">
        <property type="entry name" value="Rtp1_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039600">
        <property type="entry name" value="TANGO6/Rtp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959:SF1">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10363">
        <property type="entry name" value="RTP1_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="4">
        <location>
            <begin position="743"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="788"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="632"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="718"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="940"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="718"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW83537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1061" mass="115180" checksum="7BF5BD8D9633CF9E" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDB7</accession>
    <name>W4KDB7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_474233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545370.1">
        <property type="nucleotide sequence ID" value="XM_009547075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDB7"/>
    <dbReference type="FunCoup" id="W4KDB7">
        <property type="interactions" value="436"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KDB7"/>
    <dbReference type="GeneID" id="20677557"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_474233"/>
    <dbReference type="eggNOG" id="ENOG502QWJ9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_721907_0_0_1"/>
    <dbReference type="InParanoid" id="W4KDB7"/>
    <dbReference type="OrthoDB" id="333551at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025066">
        <property type="entry name" value="CCDC174-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13300">
        <property type="entry name" value="DUF4078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW83086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="384" mass="42289" checksum="5C6551FE991DB22B" modified="2014-03-19" version="1">MMAPASKAKAAGVSASSFFDLKAQLAKREEEVLENKAAGKVAAGAVQRRDKKISQWARQNKGVKSRAARDIELEAVDEPTLESARAALERKAKIYDKLMKGKSGGLTDKQFDMLLVDFDSKPMANFGSDSEDIDESLTVPEPLDEADPVIEYEDEFGRMRTAPRSEVPRHLLPRNVKGGDGDGDEGYVIENPVNFFPVYEPSAERTAAIDEALAEGNKPLNTHYDSTREVRAKGAGFYQFSADEETRKKQMEELLAARGETERNREDLGAVDLKPGEVDGLQASGHGLKGRATEKRKRELEERRLLLDAKRRKGKGKAEDQRLSQPIPPSPSMDEGTKPPTVTDPFVALEAQRPKPYGSTAGSIDTDAFLADIEQTIFKGRRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDD6</accession>
    <name>W4KDD6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL2m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_381028</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543534.1">
        <property type="nucleotide sequence ID" value="XM_009545239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDD6"/>
    <dbReference type="FunCoup" id="W4KDD6">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KDD6"/>
    <dbReference type="GeneID" id="20672049"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_381028"/>
    <dbReference type="eggNOG" id="KOG0438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036235_3_0_1"/>
    <dbReference type="InParanoid" id="W4KDD6"/>
    <dbReference type="OrthoDB" id="268576at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000001">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000128">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_uL2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="10">
        <location>
            <begin position="98"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="9">
        <location>
            <begin position="224"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="326"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW83788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="388" mass="42818" checksum="79A8E7A0D2E20F1C" modified="2014-03-19" version="1">MFSVRSSASLLRNCFSSLSSQTACTSRYNLLTRRYASEATLEQRPTDVNAALARTSTLFKTYKPITPGIRHLRRPLNPHIFPGRPLRLLTVPLRKNGGRNSYGRITIRHRGGGHKRRIRLVDFMRIEPGPHDVVRIEYDPNRSAHIALIHNQNPNVDGKKRWSYILAPDGLRAGNVVQSFRGGIPDGFVPGYVDSKQGGKAMTDEDKSDSTASLTLGVLRAKTIRPGNVLPLRLIPTGTVIHAIALLPDGRGILVRSAGSFGQVVAHEASGKYSQVRLQSGEVRKVLQSCCATIGKVSNPLWKSRSLGKAGRSRWLGWRPTVRGVAMNANDHPHGGGRGKSKSNKHPVSIWGWNTKGKRTRKPGPKGPKNSNKMVVRERPRGKEMRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDJ3</accession>
    <name>W4KDJ3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 20</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mediator complex subunit 20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MED20</name>
        <name evidence="6" type="ORF">HETIRDRAFT_312496</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the Mediator complex subunit 20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543655.1">
        <property type="nucleotide sequence ID" value="XM_009545360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDJ3"/>
    <dbReference type="STRING" id="747525.W4KDJ3"/>
    <dbReference type="GeneID" id="20669958"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_312496"/>
    <dbReference type="eggNOG" id="ENOG502SY8G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080203_0_0_1"/>
    <dbReference type="InParanoid" id="W4KDJ3"/>
    <dbReference type="OrthoDB" id="2536675at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013921">
        <property type="entry name" value="Mediator_Med20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08612">
        <property type="entry name" value="Med20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW83927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="290" mass="31861" checksum="02BAC7A51DBDF24E" modified="2014-03-19" version="1" fragment="single">LARWINAPTTGLDLMTENILRNHNGQFRGKWQLGVRTYRSTLNEHKANAPSERTMCALTMSENVFVLIDDPHAPTPADLALESSVIPTNPPHYRNTFLTLSPPGALEQLLTLLHARWIPTRQAASGVAQQRQASGQQLSIEGHIFAIGNDWIVRAGHVILAGGTVKGMLLEAEYLPVPAMRSRSSGDPSEPAQTVELISNLLLSVLPNISEAKIVAVTISDAQWQDVLWDREAEENAAREAEKEPKPTDDIYAVGDDDVSTHRKGDWVGVDRDRRSAYLIIGALKSEGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDQ2</accession>
    <name>W4KDQ2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Threonine/serine exporter-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_47486</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543212.1">
        <property type="nucleotide sequence ID" value="XM_009544917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDQ2"/>
    <dbReference type="FunCoup" id="W4KDQ2">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="GeneID" id="20677588"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_47486"/>
    <dbReference type="eggNOG" id="ENOG502QPMM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007078_4_1_1"/>
    <dbReference type="InParanoid" id="W4KDQ2"/>
    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ThrE"/>
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    </dbReference>
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        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
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            <begin position="180"/>
            <end position="204"/>
        </location>
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        </location>
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            <begin position="353"/>
            <end position="376"/>
        </location>
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            <begin position="3"/>
            <end position="200"/>
        </location>
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            <begin position="256"/>
            <end position="370"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW83928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="41909" checksum="265030274B37B1FB" modified="2014-03-19" version="1">MVSTFGDAGTQTSETHFVRCGGRLALGNLRKVHYIYRRVVHDEISAKKASDLLTELVDSPPIYSTFQRCTLAFILAALICPLSFGGSFIDMWIAAIAAALLCTLQLVVVSNSSLYASVFDITVTILISFTTRGLSSIGKELFCYTAISSASIVTILPGYLVLCSSLEIASRTMICGSVRMVYALVYTLFLGFGLQLGSDLYLVVDPLQRGKLASFGSALQRTVIYSCYRHPQFPWYLQPLPWWTQFLTVPLFGICLSLANLQPYRTKEFPVMVIIACVSYVTNKAADHYIFNRSEVVSAVGAFTVGMLGNIYSRKMGGTAFTSVVPGILFLVPSGLSQAGGMTADNGIDIGSAMINVVIGITVGLFISQTVSYMFGSRRNGITLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDR6</accession>
    <name>W4KDR6_HETIT</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">HETIRDRAFT_170409</name>
    </gene>
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        <lineage>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
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                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000030671">
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    </dbReference>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW83943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="106" mass="11785" checksum="4DD68426B760EAAD" modified="2014-03-19" version="1">MLAISCLLVFVVLHHRRSGNVLTESQEEMILIGALGLFWFAVLVAWRAINQQGSVGITDEVRLPAPAATTPVRGGARRPSGMTGRRRPWPCSPDDVYCVVEEWSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4KE14</accession>
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    <protein>
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    </protein>
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    </gene>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
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                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="20675096"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_439019"/>
    <dbReference type="HOGENOM" id="CLU_2542832_0_0_1"/>
    <dbReference type="InParanoid" id="W4KE14"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW84102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="83" mass="9213" checksum="D6F2ADB651D86816" modified="2014-03-19" version="1">MSCEEHFSRKFERRSYIASLPNICFPNLTCTHEASLACVAPGGDAFLLGALSRQTRSVEALKIHFCPRTKLKGIPFSLNLARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4KE33</accession>
    <name>W4KE33_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_433869</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
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                <person name="Velez H."/>
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                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545565.1">
        <property type="nucleotide sequence ID" value="XM_009547270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KE33"/>
    <dbReference type="GeneID" id="20674706"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_433869"/>
    <dbReference type="eggNOG" id="ENOG502T015">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_395365_0_0_1"/>
    <dbReference type="InParanoid" id="W4KE33"/>
    <dbReference type="OrthoDB" id="3168445at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="478"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="697" mass="72584" checksum="6272FF535AEF59C7" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KER0</accession>
    <name>W4KER0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Terpene synthase</fullName>
            <ecNumber evidence="6">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_34201</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the terpene synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="6"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543162.1">
        <property type="nucleotide sequence ID" value="XM_009544867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KER0"/>
    <dbReference type="STRING" id="747525.W4KER0"/>
    <dbReference type="GeneID" id="20671770"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_34201"/>
    <dbReference type="eggNOG" id="ENOG502SJ7W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042538_2_1_1"/>
    <dbReference type="InParanoid" id="W4KER0"/>
    <dbReference type="OrthoDB" id="2861623at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW83785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="323" mass="37769" checksum="7CB6AB276F44F623" modified="2014-03-19" version="1">MSSPFKDATNPHWKRASTESRTWVNSYSIFSDRRRAFFLQGQSELLVSHAYPYAAYEEFRTCCDFVNLLFVIDEVSDEQSPEDARLTGQTYLNVMRDPKWDDGSKLAQMTRDFRFRLMRTIKPETFRRFLQHGQDYIDCVVQEAELRERGDVLDLEAYEIIRRENSAVRLCFGLIPYVLGIDLPEEVFADPVFRRIYFAGVDMVCWANDVYSYNMEQAKGLDGNNFVTVLMKTKYMTLQQASNFVGDHYQNLMDGFIADKSRLRSFGPAIDSSVKRYIEAMQHWPVGNLFWSFETPRYFGSQRERILNTGVVYLKPLEISDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEY0</accession>
    <name>W4KEY0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine protease S28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_155109</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543399.1">
        <property type="nucleotide sequence ID" value="XM_009545104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEY0"/>
    <dbReference type="GeneID" id="20667548"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_155109"/>
    <dbReference type="eggNOG" id="KOG2182">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023630_1_1_1"/>
    <dbReference type="InParanoid" id="W4KEY0"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF23">
        <property type="entry name" value="SERINE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845402" evidence="6">
        <location>
            <begin position="23"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW83626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="545" mass="59957" checksum="7E01B58FFFA926EE" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEZ3</accession>
    <name>W4KEZ3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7704 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_449494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543615.1">
        <property type="nucleotide sequence ID" value="XM_009545320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEZ3"/>
    <dbReference type="STRING" id="747525.W4KEZ3"/>
    <dbReference type="GeneID" id="20675952"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_449494"/>
    <dbReference type="eggNOG" id="ENOG502SNUR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107228_0_0_1"/>
    <dbReference type="InParanoid" id="W4KEZ3"/>
    <dbReference type="OrthoDB" id="2937326at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056121">
        <property type="entry name" value="DUF7704"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019:SF2">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24803">
        <property type="entry name" value="DUF7704"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7704" evidence="2">
        <location>
            <begin position="6"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW83880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="169" mass="18860" checksum="E0BAE9FF457725EA" modified="2014-03-19" version="1">MSDRRSAIPAFYYAVFGVYEPILTWMGLLGTLLDPEKTHNLQAPWPRLSPPPTQLPLASIVTVVQLAHVCALLGTVNFFLLSTARRHLFAQPALQEKVISSLLTPLLAGDILHIGLTMWALGDSRWHFSEWSGTLWTTMILGLTLLVPRIAWHMGVGRYVDKRDGKVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGD2</accession>
    <name>W4KGD2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_444374</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009546225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGD2"/>
    <dbReference type="GeneID" id="20675576"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_444374"/>
    <dbReference type="eggNOG" id="ENOG502RY7K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046025_2_0_1"/>
    <dbReference type="InParanoid" id="W4KGD2"/>
    <dbReference type="OrthoDB" id="3183258at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="161"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW84897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="339" mass="37781" checksum="FD3F7716F3F602EF" modified="2014-03-19" version="1">MNVGGSWGFIMVGMMLNLILYGFMFMQCYIYLSAFKKDALWIKLFVLFLFVADTLNTGFTAGIIYEYFITHYGDFTYLSKATWLFCTDPAMTGIISCSVQVFFAYRVKRLTGSRWATAFIGFFAGASCCGALGTAIAVNWWREFVNFQKFQVVVIIWLVCAAVADVLITATLVWYLRGKRTGFVATDDIIDRITRLTVQTGALTALFAVVDVILFIASASVHPFFLPLHLLFNFPLAKLYTNSLMSNLNSRAAWESSNSKFGSSESDHGRPSANRRKPGPNVVLITKDVTSMTDGPQSFTPFSGYNAQQDQEHEHELDVMKTPGNNKGITPPNGNDTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGW6</accession>
    <name>W4KGW6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_246490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541978.1">
        <property type="nucleotide sequence ID" value="XM_009543683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGW6"/>
    <dbReference type="GeneID" id="20669117"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_246490"/>
    <dbReference type="eggNOG" id="ENOG502S2KW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022666_0_0_1"/>
    <dbReference type="InParanoid" id="W4KGW6"/>
    <dbReference type="OrthoDB" id="73919at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911:SF4">
        <property type="entry name" value="MULTIPLE C2 AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW85092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="294" mass="32311" checksum="E59BFA62A3C35A41" modified="2014-03-19" version="1" fragment="single">YVDLSIQFIGASGLPKMDVVGSGDPYFVAELDGKIKYISTVQLDTLNPVWNELWLVKNVPVTAVLNVQVLDKDNGPTDDYIGKFSISVSAGAKEAEIEGPVLKRTKGTFWLKIESNPPTNPEVPPYTFDGPIRFSRHFSPTVGRLTNLNDERLYSTWKMYIKGVPLFFGDTVQPWNHSYKAAQSIFGVGPASLAVRSGIQAGHRMLYARSTTNGFGTINSPEEIIGIFHGGSTTLGSRTLAQHRIKPAVYTYVIAVEDSSFRFSETGAAFFVDFASKHALHANCAESVRYSGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KH70</accession>
    <name>W4KH70_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_309636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542076.1">
        <property type="nucleotide sequence ID" value="XM_009543781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KH70"/>
    <dbReference type="GeneID" id="20669694"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_309636"/>
    <dbReference type="HOGENOM" id="CLU_1514079_0_0_1"/>
    <dbReference type="InParanoid" id="W4KH70"/>
    <dbReference type="OrthoDB" id="2832808at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="198" mass="22452" checksum="7512AF4E2CB359C5" modified="2014-03-19" version="1">MALPPRLVTPARLIFEAANKANVTAILFGSAAAKLHGAKRDTKDLDINVSSLGFTTFLPNEFVCHPRTVDTRQHITWANTVKCDVATERTELVNDAFETYSCVTEDGIRYASANILLADKIRTYGRRPFQAVQKQENDLYDVLQLIDVMRQKGDKMPDELKESILSEDVLRAFLERVPVEDHLLYRTFLEELNVNLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHC7</accession>
    <name>W4KHC7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_310755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542129.1">
        <property type="nucleotide sequence ID" value="XM_009543834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHC7"/>
    <dbReference type="GeneID" id="20669802"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_310755"/>
    <dbReference type="HOGENOM" id="CLU_2606320_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHC7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="79" mass="9044" checksum="CD67354A390BFB55" modified="2014-03-19" version="1">MRLDDLLGEKTARVGRHGTARRVRIIWAQCRRRIRRGSEMRRVGTSRQCGRADSRRAYVWCGSLSVSKVASVLHAVLHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIT0</accession>
    <name>W4KIT0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_414736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542580.1">
        <property type="nucleotide sequence ID" value="XM_009544285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIT0"/>
    <dbReference type="GeneID" id="20673196"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_414736"/>
    <dbReference type="HOGENOM" id="CLU_1886021_0_0_1"/>
    <dbReference type="InParanoid" id="W4KIT0"/>
    <dbReference type="OrthoDB" id="3270368at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="135" mass="15133" checksum="424A28FF24EDCE92" modified="2014-03-19" version="1">MSKSPDTIDSLLGALKNSAEAESKEIRDTVDYISSWLTSLFNSSVPSSEFSKRVSQKLRYSLRPLYTAAPASSFQLSAAVFAKIISDKIIHAAQNQKMKVRYAWEPIAESIISGVLDHLDDKNNGENRHNTIYYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJI3</accession>
    <name>W4KJI3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_145783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP4R2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542800.1">
        <property type="nucleotide sequence ID" value="XM_009544505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJI3"/>
    <dbReference type="STRING" id="747525.W4KJI3"/>
    <dbReference type="GeneID" id="20667099"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_145783"/>
    <dbReference type="eggNOG" id="KOG3175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056027_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJI3"/>
    <dbReference type="OrthoDB" id="341898at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015267">
        <property type="entry name" value="PPP4R2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487">
        <property type="entry name" value="PPP4R2-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09184">
        <property type="entry name" value="PPP4R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW86012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="321" mass="34916" checksum="3A3BBFF4D91864FE" modified="2014-03-19" version="1">MAMAHDTHNISSGFKWSEDYDATLERIASTDDVETQWAQLRDIIKYKIEQNITSFLADAEKLVKSEGLRLFSPQPSTTGGLKLPPFPPRPPVAPSLDPCPKNHFTKEEASAFKESLYAQLDGFDGIPFTIQRISDLCVRPREHYRSVGKYLRAIEKAVYVTSTWDSFPPLSPQAAGPEAIASTAFGTGSSSVPSTPLFSPIPFLHGDARRSTSRSPPPLALSAVTPGGGTPLDTTVLGMEHRGLGLVDELDDPGIGHMSDHPTALSSVTSVGRGSGAKSLDERFVRASENRVGPESKRQKPNEDIEDMLLDERDGDKENKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJQ8</accession>
    <name>W4KJQ8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucan synthase</fullName>
            <ecNumber evidence="3">2.4.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_154319</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
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        <reaction evidence="9">
            <text>[(1-&gt;3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21476"/>
            <dbReference type="Rhea" id="RHEA-COMP:11146"/>
            <dbReference type="Rhea" id="RHEA-COMP:14303"/>
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            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.34"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 48 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.34" evidence="3"/>
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        <property type="protein sequence ID" value="ETW85934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051278">
        <property type="term" value="P:fungal-type cell wall polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
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        <property type="entry name" value="FKS1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF48">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FKS1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="420"/>
            <end position="438"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="450"/>
            <end position="471"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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    <feature type="transmembrane region" description="Helical" evidence="11">
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    <feature type="transmembrane region" description="Helical" evidence="11">
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    <feature type="transmembrane region" description="Helical" evidence="11">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <end position="1363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1439"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1471"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1512"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1542"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1615"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1668"/>
            <end position="1692"/>
        </location>
    </feature>
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        <location>
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            <end position="303"/>
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            <end position="43"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012589"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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    <evidence type="ECO:0000256" key="8">
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047777"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW85934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <subcellularLocation>
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    <dbReference type="PANTHER" id="PTHR13146:SF0">
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    </dbReference>
    <dbReference type="Pfam" id="PF04142">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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            <end position="44"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="117"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="143"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="172"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="226"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        <location>
            <begin position="53"/>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="380"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="428"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW85486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="439" mass="48496" checksum="31439983B9CB96E9" modified="2014-03-19" version="1">MQCVENCDDPISRHHVLYEQPVWQTLQMFLGEMLCFLPVLYAWIASRRSSSVRLPPDADPQDSIIPTPPTDQPSEPELAGSFSKLPPPQLSGWRILLLWLPAFCDLTGTTLMNIGLLYTPVSIYQMTRGALVLFVGILSVLFLHRRLWLYQWISLITVMAGVSLVGFSGSLIKDSLHETVTSLLNATAPSDGPVAEPIEQPEATRVLIGVFFILFAQIFTATQFVVEEKILSRYAVPPLLAVGYEGLFGTLSIFLLLPILPLITIPADSPAAPWFDLPRGWHQLVDTPSVLYSGLVIAVSISLFNFFGLSVTRHVSATARSLTDTCRTLAIWIVSLGLGWEVLVWPISLVQVLGFGLLVYGTFLFNNLVNPPRFLWRPAPATARAPSDSDETVTEALLAPETEEERREALDETAALPADLGQSGFDVVPRERSRSRSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKH2</accession>
    <name>W4KKH2_HETIT</name>
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        <recommendedName>
            <fullName evidence="4">DUF3835 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_415253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009544766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKH2"/>
    <dbReference type="GeneID" id="20673233"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_415253"/>
    <dbReference type="eggNOG" id="ENOG502SIW5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027151_0_0_1"/>
    <dbReference type="InParanoid" id="W4KKH2"/>
    <dbReference type="OrthoDB" id="21413at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="493"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="739" mass="80051" checksum="6EB6C004072A5874" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4KL86</accession>
    <name>W4KL86_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_414778</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the citrate synthase family.</text>
    </comment>
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        <property type="protein sequence ID" value="ETW85796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542618.1">
        <property type="nucleotide sequence ID" value="XM_009544323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KL86"/>
    <dbReference type="STRING" id="747525.W4KL86"/>
    <dbReference type="GeneID" id="20673200"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_414778"/>
    <dbReference type="eggNOG" id="KOG2617">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022049_2_1_1"/>
    <dbReference type="InParanoid" id="W4KL86"/>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010109">
        <property type="entry name" value="Citrate_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01793">
        <property type="entry name" value="cit_synth_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF15">
        <property type="entry name" value="CITRATE SYNTHASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR610109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW85796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="462" mass="51216" checksum="2928BED361C0C824" modified="2014-03-19" version="1">MFRHASSSARSLSRNSPLGRRLASTRTLKQALQEVIPAKQEQLRRLKAEHSHKVVGDVTVENIIGGMRGLKSMLWEASVLDPNEGIRFHGLSIPDCQQQLPAAPGGKEIIAESMLWLLMTGKVPTEAEVRQLSQELAEKGELPDFVERLVDSLPQSLHPMTQLGIGVAALNHDSAFQAAYEKGIKKSEYWTYTLEDCVNLIARLPALAARIYRNVYRPGTELPGIKKDLDLVGNYTNMLGYGNNHDLTEYLRLYISIHGDHEGGNASAHTAHLVGSTLSDPYISYSAALFALAGPLHGLANQEVLRWQLSMMKDIGNDITHDHIKEYLWRTLKSGQVVPGYGHGVLRKSDPRFIALQEFCDTRPDLLASPIIQLVKKTYEVAPGVLMEHGKSKNPWPNVDAASGCVLYHYGLDEFKYYTVIFGVSRALGALTQLVWARALGLPLERPKSLSLDVLEKLTESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLA5</accession>
    <name>W4KLA5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_456582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540611.1">
        <property type="nucleotide sequence ID" value="XM_009542316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLA5"/>
    <dbReference type="GeneID" id="20676757"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_456582"/>
    <dbReference type="HOGENOM" id="CLU_1107251_0_0_1"/>
    <dbReference type="InParanoid" id="W4KLA5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="251" mass="27970" checksum="C883C70B65B347AB" modified="2014-03-19" version="1">MRVRRDGNELRVGGRLRVGTRTDDGVVGLEAGDDDEEQGGREKKRGGKRGFRRKRASDCDRLDVKRGGERESHESQSQACLEASFGPVPSSAVLSSHVSVPRRFTLPRFRPPPIRRHSAVPSASAPAVRHRWPVRPLHPPHRARSRPALCRPPSLSVRQIPTQFRFHPCPALPFHISTTSPQIHSRAPPHGRTRPVRQTCPSSHTHPPAYGNFPHPRAPTDKNRLELLKTAPPSSSPDLSQRGTLDDDARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLI5</accession>
    <name>W4KLI5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Translocase of outer membrane 40 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HETIRDRAFT_122349</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Channel-forming protein essential for import of protein precursors into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542712.1">
        <property type="nucleotide sequence ID" value="XM_009544417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLI5"/>
    <dbReference type="FunCoup" id="W4KLI5">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KLI5"/>
    <dbReference type="GeneID" id="20666782"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_122349"/>
    <dbReference type="eggNOG" id="KOG3296">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042174_2_0_1"/>
    <dbReference type="InParanoid" id="W4KLI5"/>
    <dbReference type="OrthoDB" id="19656at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000009">
        <property type="entry name" value="Mitochondrial import receptor subunit TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-0626">Porin</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETW85906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="355" mass="38259" checksum="1902680A5D33D5E1" modified="2014-03-19" version="1">MAAISSEKSSFADVGSISAPSSSKPSSFSALSPLTNVYRRFSDWRSALGLPNPGSVENLQKEIKNTHLTNFFFDGARADLMKGLSMDPAFQVTHSFSLASQSAPPSYNFGAVFANQQVFLQGSVDHEGNVNARLNQGWSPTNVTKIQAQLSSQAGHNMIQLEHDYQGLDYSVNAKAINPSPTDGTGVYVSTYLQSITQKLALGVESVYQHQSAQLTDFSMSYLAKYTGANKDWIATASVQPAGILQATYWHKLSEKVEAAADLQLIAAPGRRDAIAVLGAKYDLRMSTFRAQLDSTGKVSALLEQRFAPTFAFTVAGEIDHFKNSAKVGVGVMIESTSLTPEEMGMTMPPGPPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMB4</accession>
    <name>W4KMB4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_41237</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540328.1">
        <property type="nucleotide sequence ID" value="XM_009542033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMB4"/>
    <dbReference type="STRING" id="747525.W4KMB4"/>
    <dbReference type="GeneID" id="20673023"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_41237"/>
    <dbReference type="eggNOG" id="KOG1864">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008279_12_0_1"/>
    <dbReference type="InParanoid" id="W4KMB4"/>
    <dbReference type="OrthoDB" id="27652at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="6">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW86520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="201" mass="23018" checksum="912E5A708025A91F" modified="2014-03-19" version="1" fragment="single">PHPHTLVHRLFEGVLTSETRCLTCETVSARDESFLDLSIDIEQNSSVTACLRQFSASEMLCQRNKFFCDSCCGLQEAEKRMKIKKLPNVLALHLKRFKYQDDVQRYIKLAYRVAFPRELRLFNTVDDAEDPDRLYELFAIVVHIGNGPHHGHYVTIARAPDAGWLAFDDDKIESVREADIPRYFGDSPAGAAYVLYYQAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KN31</accession>
    <name>W4KN31_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_308315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540472.1">
        <property type="nucleotide sequence ID" value="XM_009542177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KN31"/>
    <dbReference type="GeneID" id="20669571"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_308315"/>
    <dbReference type="HOGENOM" id="CLU_2694487_0_0_1"/>
    <dbReference type="InParanoid" id="W4KN31"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="74" mass="8135" checksum="5C37AA67DAA74707" modified="2014-03-19" version="1" fragment="single">VVKGSGRSGEVFDEPAIEVSKAQEGLYFLQVLRSWPGGDSINLDGVHRYIIRGDDESEVFDCVRFEGALGGFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPV1</accession>
    <name>W4KPV1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_166612</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541029.1">
        <property type="nucleotide sequence ID" value="XM_009542734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPV1"/>
    <dbReference type="GeneID" id="20668068"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_166612"/>
    <dbReference type="HOGENOM" id="CLU_088618_3_1_1"/>
    <dbReference type="InParanoid" id="W4KPV1"/>
    <dbReference type="OrthoDB" id="5316007at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052479">
        <property type="entry name" value="GPI-anchor_Adhesion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185">
        <property type="entry name" value="SERINE/THREONINE-RICH PROTEIN ADG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185:SF1">
        <property type="entry name" value="UPF0619 GPI-ANCHORED MEMBRANE PROTEIN C1322.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012361910" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="3">
        <location>
            <begin position="20"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW87086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="128" mass="13781" checksum="9AB58D89C54CC82D" modified="2014-03-19" version="1">MHFLVILSLATFSLAYQVTSPASGTSWSCLGPNTMTWTRAPTDPPTFAVVLVNDKYGTADFCAWGVDGSLNQTAMSPPYGRGQFIPGDGYHLNVVRDTDHYNAILAQSNLFSISQCETLLSSAEASEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KQV1</accession>
    <name>W4KQV1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_100076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541634.1">
        <property type="nucleotide sequence ID" value="XM_009543339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KQV1"/>
    <dbReference type="STRING" id="747525.W4KQV1"/>
    <dbReference type="GeneID" id="20665663"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_100076"/>
    <dbReference type="HOGENOM" id="CLU_083072_0_0_1"/>
    <dbReference type="InParanoid" id="W4KQV1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="271" mass="30413" checksum="5446DC80CC46E5CA" modified="2014-03-19" version="1">MSSSGSIYLSSKDTLIERPYKETPSTEPSIPSTPEMSIVEERSVPWDMDEEQAARKAEEGFSEYLEGLDENERREDEMIRRLTEDFDRPSPSRSPSPPPLICTQSKGIIFPDRETYLTTPVAYMMGLIEGTPNTEFVSGPTQPEIQRALEILEEERSFVRHAQRALQIREGTLIARINAGERRLMGLNQTTCLQDSFHPANDITPVTEYHMPTTAVVSCASSSASNGVPLRPMPGAYPMERGRGRDTYRFAQISPCYHVIPTWLGVIHSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>W4JM69</accession>
    <name>W4JM69_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium-transporting ATPase 1</fullName>
            <ecNumber evidence="2">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HETIRDRAFT_39936</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="2"/>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553045.1">
        <property type="nucleotide sequence ID" value="XM_009554750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JM69"/>
    <dbReference type="FunCoup" id="W4JM69">
        <property type="interactions" value="271"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JM69"/>
    <dbReference type="GeneID" id="20672505"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_39936"/>
    <dbReference type="eggNOG" id="KOG0202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_3_3_1"/>
    <dbReference type="InParanoid" id="W4JM69"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031090">
        <property type="term" value="C:organelle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000008">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="943"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="977"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1006"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="19">
        <location>
            <begin position="146"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="673"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="676"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00067949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ETW74623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1079" mass="115883" checksum="E170438D66B7C074" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMG8</accession>
    <name>W4JMG8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">GST8</name>
        <name evidence="6" type="ORF">HETIRDRAFT_442680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553211.1">
        <property type="nucleotide sequence ID" value="XM_009554916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JMG8"/>
    <dbReference type="FunCoup" id="W4JMG8">
        <property type="interactions" value="198"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JMG8"/>
    <dbReference type="GeneID" id="20675476"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_442680"/>
    <dbReference type="eggNOG" id="KOG2903">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037263_0_1_1"/>
    <dbReference type="InParanoid" id="W4JMG8"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000162">
        <property type="entry name" value="Glutathione S-transferase Gst3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01148">
        <property type="entry name" value="Xi_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="160"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="144"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="3">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="3">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW74723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="321" mass="37180" checksum="6E771438444E3515" modified="2014-03-19" version="1">MAAAARDVSHQSNIAKMRTDGDGSFKRLPSTFRSAVEKGGQFPPEKDRYHLYVSYACPWATRTLIMRKLKGLEDIVPVTVVSPHMGELGWPFASVDNFPGADVDPLYNAQHVKDLYLRANPEYSGRFTVPVLWDKKQHTIVNNESSEIIRIFNSAFNDTISKEKAELDFYPQHLRKEIDEVNEWVYDSINNGVYKSGFATTFDAYRAAVVPLFESLDRVEVMLKDKTYFIGDRLTEADIRLFVTLIRFDPVYVGHFKCNLRTIRHGYPNIHLWLRKLYWQNDAFQSTTDFDHIKTHYYWSHPMVNPHRIVPIGPVPHIEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4JN74</accession>
    <name>W4JN74_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4100 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_423599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW75012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553464.1">
        <property type="nucleotide sequence ID" value="XM_009555169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JN74"/>
    <dbReference type="GeneID" id="20673916"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_423599"/>
    <dbReference type="eggNOG" id="ENOG502SRIE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003921_0_1_1"/>
    <dbReference type="InParanoid" id="W4JN74"/>
    <dbReference type="OrthoDB" id="2801388at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025165">
        <property type="entry name" value="DUF4100"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13352">
        <property type="entry name" value="DUF4100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4100" evidence="2">
        <location>
            <begin position="132"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW75012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="469" mass="52070" checksum="D471A9E61940A6CF" modified="2014-03-19" version="1">MFCGSPKHFMRTCPEVTEYIRIGKCKRNIEGKVVLSSGAFVPREITGSNLKDRVDEWHRRNPGQLATGQMMFTVNAAPTHPMTIASRHDSPSLLEVTPTYQLTDVQQIASLERELFALRTWGARAREMAQTGRSASTPSPAPERRARTETPEPEPRPTSPTQRPPPVPAKDDAPVHPYAKAQDATYALPHERNMGAPVKIPSAKKDAPAYKTTAPIYDEKVAAEVYNRAMATQVTLTQRELLSLSAEVRSQVREATSARRSPTKDTSNVRTFYQDADLPYAIDDLEPPTRPTVSSFVNVLHQPETPPPGAIIIPDMYKTYLKNLQPSQVPLPLIVAKESSALRSIVPLVDHQQEVECVIDPGSQVIAMSEGICNELVLIYDPKIILNMQSANGEIDRSLGLTRNIPFLIGDITLYLQVHIIQNPAYNVLLGRPFDILTESIVKNYSNKDQMITNSDPNTGRRATIPTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4JN96</accession>
    <name>W4JN96_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_16962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553033.1">
        <property type="nucleotide sequence ID" value="XM_009554738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JN96"/>
    <dbReference type="STRING" id="747525.W4JN96"/>
    <dbReference type="GeneID" id="20668227"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_16962"/>
    <dbReference type="eggNOG" id="ENOG502SYFS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181169_0_0_1"/>
    <dbReference type="InParanoid" id="W4JN96"/>
    <dbReference type="OrthoDB" id="3256305at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW74949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="100" mass="11243" checksum="8166B2FDA138AD53" modified="2014-03-19" version="1" fragment="single">PQCTACLRWGYPTPLCRSPTYRCAQCAGHHSVQDHRQLADCCHGDNPTPNGHPCPHSPSCANCSGPHKATDRSCPFYQNWHNAEWIEQHQSNPSDQRPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W4JND9</accession>
    <name>W4JND9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Very-long-chain 3-oxoacyl-CoA reductase</fullName>
            <ecNumber evidence="12">1.1.1.330</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">3-ketoacyl-CoA reductase</fullName>
            <shortName evidence="12">3-ketoreductase</shortName>
            <shortName evidence="12">KAR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Microsomal beta-keto-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HETIRDRAFT_127021</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">TC 32-1</strain>
        </source>
    </reference>
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        <text evidence="12">Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + NADPH + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="EC" id="1.1.1.330"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endoplasmic reticulum membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.330" evidence="12"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="747525.W4JND9"/>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_127021"/>
    <dbReference type="eggNOG" id="KOG1014">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF2">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0521">NADP</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETW75058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="310" mass="33025" checksum="56CCFD88E422A03C" modified="2014-03-19" version="1">MAPAPVSLVLQAVGALTIAYLLLSFSSVLLRAFVLPGKPLKKFGAKQGAWAVVTGASDGIGREFALQLARAGFNVFLAARNPDKLAAVASEISDVQTRTFAIDFAHADDAVYQSLSDALAELDIGVLVNNVGKSHEMPSDFVDTPADEIRDILAINVSATLRVTSLVTPGMVSRHRGLILNIGSFGGAAPAPMLATYGASKAFLATFSDALAAELGPKGVTVEHSNTYFVVSSMSKIRRPSLLIPLPNAYVRAVLRGIAPGTQIPYWSHALLGFVMRLAPAQVVLQYTHALHKDIRKRALKKKEREAKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNW3</accession>
    <name>W4JNW3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_481934</name>
    </gene>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW75247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="83" mass="8941" checksum="4ADFF95CE8B756DF" modified="2014-03-19" version="1">MRRAGSGLTDTRGRPAEAQMRRQAGRQAGRTGQGRAGQGRAGQGRASIYSAIFIQVVFGFWFRFLFACLLGSRHVRIGGSAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQ97</accession>
    <name>W4JQ97_HETIT</name>
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        <submittedName>
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    </protein>
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        <name evidence="2" type="ORF">HETIRDRAFT_108301</name>
    </gene>
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        <lineage>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW75051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553497.1">
        <property type="nucleotide sequence ID" value="XM_009555202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQ97"/>
    <dbReference type="GeneID" id="20666333"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_108301"/>
    <dbReference type="HOGENOM" id="CLU_852743_0_0_1"/>
    <dbReference type="InParanoid" id="W4JQ97"/>
    <dbReference type="OrthoDB" id="2142759at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="326" mass="36714" checksum="E5D8BFF302EC725B" modified="2014-03-19" version="1">MNFEGVEVAHFFPLAWFDMSSEVKDLKGEATHDALKKSYDSSENGILLRKGIHDHQFGISNGAIYRFEKSGTSSLSNISPDLKQPVKDAPPRPDSDDPPRPDSDDSSRSDSNDPPHVPDLNQDFLDLHHKIGVLLNVAGGGTRFSRLREHRCIRARHEPTKARYRNTHRLAPIPPRRSLGQEHPEALRARPADASMKEAPPPTASDRTVGRRAARNLEGLRGARLTRWRHRSRVQNRRRTPEAPFAPEVKWTRASVRPKGKGQMWDPRRAHARASPSSPEFGFRARSTLRFHVGKRAGSIRCSHRKKQAQASASRTPHPCRRVAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQF8</accession>
    <name>W4JQF8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_390687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552572.1">
        <property type="nucleotide sequence ID" value="XM_009554277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQF8"/>
    <dbReference type="FunCoup" id="W4JQF8">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="GeneID" id="20672461"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_390687"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_0_0_1"/>
    <dbReference type="InParanoid" id="W4JQF8"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="381" mass="42015" checksum="4749DB52ACD5C605" modified="2014-03-19" version="1">MSSIKLFQPIEFGDVTLQHRVVMSPLSRFRANAAHVNGDLSRQYYEQRASVPGTLIISEGTLISAKAGGSPNAPGIWSEDQIIHWKKIVDAVHAKGSFIYLQLWALGRAAYPAALVAEDPSFPYVSSGNVKLDDREETPRALTIPEIKEYVEMYATAAANSVHKAGFDGVEIHGANGFLPDQFLQTTANNRTDEYGGSIENRIRFTLEVVDAVVKAVGGAQRVGLRLSPWSSYQGMYMKDPNPSFAALITAIKRKHPTFGYLHVIHARVDGAAIREIKPEENDDFLRQIWGDKIYLSCGGYTREDAIETADKKGGLVVFGRSFISNPDLPLRLKKNYALAQPDYTTLYTAESPKGYIDYPFYSEIEPETTTVSASGVTVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQP5</accession>
    <name>W4JQP5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_164637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552654.1">
        <property type="nucleotide sequence ID" value="XM_009554359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQP5"/>
    <dbReference type="STRING" id="747525.W4JQP5"/>
    <dbReference type="GeneID" id="20667927"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_164637"/>
    <dbReference type="HOGENOM" id="CLU_129974_1_0_1"/>
    <dbReference type="InParanoid" id="W4JQP5"/>
    <dbReference type="OrthoDB" id="2923369at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="46"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW75216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="81" mass="9416" checksum="D2BAA59D3718B0EC" modified="2014-03-19" version="1">MQTNITVVEWFQKSVDDDFGRKIEQWIDAPDSSKNYFNALEKHQKDTCSWFINGPQFADWKNQGLPFIWVYGIPGCGKSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQZ3</accession>
    <name>W4JQZ3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bacterial surface antigen (D15) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_461096</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAM50/omp85 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552198.1">
        <property type="nucleotide sequence ID" value="XM_009553903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQZ3"/>
    <dbReference type="FunCoup" id="W4JQZ3">
        <property type="interactions" value="434"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JQZ3"/>
    <dbReference type="GeneID" id="20677138"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_461096"/>
    <dbReference type="eggNOG" id="KOG2602">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014798_3_1_1"/>
    <dbReference type="InParanoid" id="W4JQZ3"/>
    <dbReference type="OrthoDB" id="1724197at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF18">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="6">
        <location>
            <begin position="129"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW75963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="442" mass="47844" checksum="4EC1BF943EDA2B21" modified="2014-03-19" version="1">MSSHSLHLADLVNESLDFPARIASVRVDGALHTRKTFLASLIDTYLPHDQPSNLASVLRTTREISHILQRTDVFKSIDVKLERSRAALAGESDVDVIFTTQERGRFYVKTSTEVGNNEGSANATGRIRNAFGGAEVLEANVSVGTKTRRSFHATLSAPVTSTLKTFGDVSVFALDRDYTGHASCTEGLRGVKATLKSGSPSTGQHEVGYEAVLRHVGNLMPSASISMREATGQSIKSSVFHTWIRDTRDAKFPSSRGYFTKLFHELAGLGGDVSFYKTEAETRISRPLLPGLSLSLSGRAGLLYSLKGLSRFSDRFQLGGPLSVRMFRANAMGPRDGSDAVGGDVYWAAGLNLTSTIPRRTQWPLRAQLFVNAGQLQALQPSKTLSRNLSTCALQPSVSVGVGLVYLFDPLKVELNFGVPLVAARSDGCRKGFQIGMGLEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRY8</accession>
    <name>W4JRY8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_119185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552102.1">
        <property type="nucleotide sequence ID" value="XM_009553807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRY8"/>
    <dbReference type="GeneID" id="20666635"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_119185"/>
    <dbReference type="HOGENOM" id="CLU_504383_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRY8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="540" mass="60140" checksum="A554A1D9FD1F8555" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSP7</accession>
    <name>W4JSP7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_106530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552121.1">
        <property type="nucleotide sequence ID" value="XM_009553826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSP7"/>
    <dbReference type="GeneID" id="20666170"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_106530"/>
    <dbReference type="HOGENOM" id="CLU_2133830_0_0_1"/>
    <dbReference type="InParanoid" id="W4JSP7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW75881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="113" mass="13010" checksum="8618922267AFAE94" modified="2014-03-19" version="1">MQLVLGYLVNEIWLRDYAKQHQYYGDLDPETLALYHESAYPILIRSEEMDGLYEAGCDLIARCGMRATLNPVWISNCESCFCWCISRSFHPNTRTPEEAALLERFKDLIGAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTE1</accession>
    <name>W4JTE1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3'(2'),5'-bisphosphate nucleotidase</fullName>
            <ecNumber evidence="3">3.1.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_460760</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3'-phosphoadenylyl sulfate + H2O = adenosine 5'-phosphosulfate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:77640"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine 2',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:194156"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:77644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine 3',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:10041"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.7" evidence="3"/>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551288.1">
        <property type="nucleotide sequence ID" value="XM_009552993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTE1"/>
    <dbReference type="FunCoup" id="W4JTE1">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JTE1"/>
    <dbReference type="GeneID" id="20677110"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_460760"/>
    <dbReference type="eggNOG" id="KOG1528">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033446_2_1_1"/>
    <dbReference type="InParanoid" id="W4JTE1"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01517">
        <property type="entry name" value="PAP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000003">
        <property type="entry name" value="PAP-specific phosphatase HAL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006239">
        <property type="entry name" value="DPNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01330">
        <property type="entry name" value="bisphos_HAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF6">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW76370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="346" mass="36658" checksum="CEA2B7A4E9E6D740" modified="2014-03-19" version="1">MSIPFATEQQVAIAAVRRACTLTTAVFNNLVKGETLVKGDKSPVTVADFSAQAVINTVLLHAFPSDPIVGEEDAADLHDNDALRSRVVELANDCLKAELGQGEMAEWGLGRTRTEAELLSAIDRGQYEGGRKGRMWTLDPIDGTKGFLRGEQYAVCLALLVDARVELGVIGCPNLPLDPSNPSGPRGCIFVAVRGQGAQQLTLSGGSPISLKMPELQPSELNLLESVESAHAALGVNDRVAKILGVTRPPTRMDSQAKYGALARGDGGVYLRLPTGVGYREKIWDHAPGALLIEEAGGVISDGRGEPLDFGQGRTLGENFGVVATGKGIHSKIIEAVKWAQGEMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUH7</accession>
    <name>W4JUH7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_174152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550746.1">
        <property type="nucleotide sequence ID" value="XM_009552451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUH7"/>
    <dbReference type="GeneID" id="20668491"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_174152"/>
    <dbReference type="eggNOG" id="ENOG502R0Z7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032057_0_0_1"/>
    <dbReference type="InParanoid" id="W4JUH7"/>
    <dbReference type="OrthoDB" id="3261465at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW77208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="639" mass="72945" checksum="0B390F9A434313EA" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVH6</accession>
    <name>W4JVH6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF300-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_442143</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551728.1">
        <property type="nucleotide sequence ID" value="XM_009553433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JVH6"/>
    <dbReference type="STRING" id="747525.W4JVH6"/>
    <dbReference type="GeneID" id="20675418"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_442143"/>
    <dbReference type="eggNOG" id="KOG2641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012923_7_0_1"/>
    <dbReference type="InParanoid" id="W4JVH6"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="405"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW76861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="49205" checksum="017D0FD99865366F" modified="2014-03-19" version="1">MPVCTAENTQAVDQSGFWDENGIDWDSHRIGWAIAGGCSILTVIISFVSVMMHCRNYNNPAEQRQIIRILYMPPVYAIISFFSYRYFRDYTYYSLIEVVYEAVTISAFLLLLIEYVASTAVGHSAENAIARKDKSPLPLPFCCWRYRPTKAYFMYTVKWSVLQYVIVRPAVSIAGIICEKYKVLCESGSYNVHFAKVYLDAIDFVSISVALYGLILFYGLTKEELKGRRPLSKFLSIKLIVMFTFYQSFVFSALEGRVIHGTQYWTATNISDGLNALATCIEMIFFAAFMMWAYTWNEYTTKGGAHTGIFRPLWDRCAVYTMCHITSNSECCSINYIDFAREILSSLSFYATTVTHQPRNRSHGPEIEEPKRDFGQAFGVEGYRITRRKSLGEYDDAIGLAPRTTALRGSHGRGSNNGSPAGSAGTLSYEEPHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWW3</accession>
    <name>W4JWW3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_327571</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550873.1">
        <property type="nucleotide sequence ID" value="XM_009552578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWW3"/>
    <dbReference type="STRING" id="747525.W4JWW3"/>
    <dbReference type="GeneID" id="20671342"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_327571"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161749_0_0_1"/>
    <dbReference type="InParanoid" id="W4JWW3"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW77356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="127" mass="14166" checksum="D2AEB5B4C3CFBA7F" modified="2014-03-19" version="1" fragment="single">GNAHVLPAFNANFGITNNNKWTLALSIFYVGYCKSRNLLKASTVSDSSISSPGLLEMPANVLQRQIGANRFFFISLTFWGLASLSFVYAKGYPALLALRILLGIGEAGYYAGMIYYLSFWYRRCTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4JX13</accession>
    <name>W4JX13_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">6-phosphofructo-2-kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_441475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550005.1">
        <property type="nucleotide sequence ID" value="XM_009551710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JX13"/>
    <dbReference type="STRING" id="747525.W4JX13"/>
    <dbReference type="GeneID" id="20675367"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_441475"/>
    <dbReference type="eggNOG" id="KOG0234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006383_0_0_1"/>
    <dbReference type="InParanoid" id="W4JX13"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001280">
        <property type="entry name" value="Related to 6-phosphofructo-2-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF39">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2,6-BISPHOSPHATASE YLR345W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW77999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="484" mass="55444" checksum="F2C3ADA787F9507E" modified="2014-03-19" version="1">MVPPLYTTASGLLFHAGKILVITVGLPARGKTHISRALERYLRWAGVKTQVISLGDYRRKTIGGAQKLPPDYFTLGEKSPETVALRERVQAGCEQMIWEFFNGGGQVVIYDANNGTQAQRQRLAEKFNKDEIHVVMLESMCDDNTIIERNIRSVKISSPDYKGWDPDKAVKDYYGRIRDHEKHYETVEELTWPFIRIINVGEKIMVNNIRGYLQSRIVFFLMNIHNKYRTIYFARSGHSLIEHSYKADADLSPAGWEYAERLKDFVLDRRAKSLEQRGIHPKDSRLVIWTSARRRAHHTAWPFLAAAERKGPGGAQLNVKVIEKPQMSEINPGVWDGLTPDQARKYYPEEWERFSKDPYAFRAPRAESYHDLSVRLEPTLIELEREQEDLLIIGHASVIRCLLAYLIGLPASEIPAIEIARGDLLEVVPASYGVHSQAYHFWDGHGRKHGNENVASTSGSENNFYENYAEDTQGKRRVGYEEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4JX69</accession>
    <name>W4JX69_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_327684</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550978.1">
        <property type="nucleotide sequence ID" value="XM_009552683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JX69"/>
    <dbReference type="STRING" id="747525.W4JX69"/>
    <dbReference type="GeneID" id="20671349"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_327684"/>
    <dbReference type="eggNOG" id="KOG2885">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029148_1_0_1"/>
    <dbReference type="InParanoid" id="W4JX69"/>
    <dbReference type="OrthoDB" id="444809at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029190">
        <property type="entry name" value="Rrp14/SURF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029188">
        <property type="entry name" value="Rrp14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007019">
        <property type="entry name" value="SURF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369:SF0">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15459">
        <property type="entry name" value="RRP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04935">
        <property type="entry name" value="SURF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA-processing protein 14 N-terminal" evidence="6">
        <location>
            <begin position="11"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal" evidence="5">
        <location>
            <begin position="188"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="37"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="306"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="185"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="306"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW77476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="47613" checksum="D96CA59DE31F74E8" modified="2014-03-19" version="1">MPTSAAALHASLEKHNATFESLLRLIPAKFYLVQDDGDDQVRSSKYHKNKRNKQAPKQAIKEASKKARREKLDPANNKSILDIQNERASASARAKKGKAKQAQKHPADDASDEEDGAADVTLDLDLDGHDDVNEDDEFDEDEAAEIVPMPESQSIDALRAKLHARMSTLRNRGRRPPGEYPQDVGSRDELLEERRQQRAAMRERRRKETREKIRREEEQRGKKGKDKDKGRDKAQTTKTQLLVPDRPPSSRPAHDPKSPFTNIAFSTLATPADAPSSSKKAHQRLTTSANPTQALAQLAARKERLAALPADKRRQIEERERWQKAEARMEGVKVRDDEARLKKAVKKDEKEKGKSKKSWDERKEQIGAAMAARQKKRTDNIAQRNERRSDKRKGTKPKASSKARPGFEGKAFGKGKGKKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4JX89</accession>
    <name>W4JX89_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_164152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550172.1">
        <property type="nucleotide sequence ID" value="XM_009551877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JX89"/>
    <dbReference type="GeneID" id="20667895"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_164152"/>
    <dbReference type="HOGENOM" id="CLU_882957_0_0_1"/>
    <dbReference type="InParanoid" id="W4JX89"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="315" mass="34934" checksum="3B429E38F734678B" modified="2014-03-19" version="1">MPSISTSSAAPRISSLLRRLPFYNRGPAMTSAQLLEKKLAKALISLKNPPTMRERVKRMGDRCFEKVRHVKKTGGSSNVVEREAPIWVDRSGYVTVTFVADGEHELQFSSSPVRIKTPVRLVESVIAPDTTALHPESNDPFPSKLSGEENMRQIDLLLTMAQNTFSDDKHSTPVDTITLEACDIASGGSSCEPPSSPKPIQHPDVTMGMGFDVLAFLKELGEMSEAEAQSRCLYASQSMEHEQEQDVHLQELWAQFMHFPEVAPAEIPSPILEPIPIIQVNGQEVEIFDIDAIWAEAIAVKKARGPEVEVFTELW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXC8</accession>
    <name>W4JXC8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NTF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_479306</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550114.1">
        <property type="nucleotide sequence ID" value="XM_009551819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXC8"/>
    <dbReference type="STRING" id="747525.W4JXC8"/>
    <dbReference type="GeneID" id="20677863"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_479306"/>
    <dbReference type="eggNOG" id="KOG0116">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022209_2_1_1"/>
    <dbReference type="InParanoid" id="W4JXC8"/>
    <dbReference type="OrthoDB" id="339151at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990861">
        <property type="term" value="C:Ubp3-Bre5 deubiquitination complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000003">
        <property type="entry name" value="Nuclear transport factor 2 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039539">
        <property type="entry name" value="Ras_GTPase_bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693:SF20">
        <property type="entry name" value="AT27578P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="NTF2" evidence="5">
        <location>
            <begin position="34"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="401"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="174"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="254"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="335"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="486"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="174"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="290"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="496"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="514"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="529"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW78114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="55778" checksum="6A4A9DB7F5C9E54D" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXG3</accession>
    <name>W4JXG3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450 monooxygenase 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">cyp24</name>
        <name evidence="15" type="ORF">HETIRDRAFT_56199</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="747525.W4JXG3"/>
    <dbReference type="GeneID" id="20678351"/>
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    </dbReference>
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    <dbReference type="InParanoid" id="W4JXG3"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
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        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETW78252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="507" mass="57644" checksum="78BBEA62BC6B8539" modified="2014-03-19" version="1">MTELPASHNLIFVASTIAFLTFLIIRYTRSPWRKLPPGPRGFPLVGNVLQPNSQLWLSFTQWKKTYGDLVYFHILGQPFLVLNSQQAATDLLDRRASIYSDRPRNVINMMTEERNSWRRMRKAAHGGFNKNVVKKYHNTQTTEAILLVHGIATDPIRWDQHLRRAAASVIMSVVYGTPPIESNSDPSIANINELVAQVTTAAHPGAHLVEFFPWMIYIPERFATWKHQAEGWFSRGTIIFEGLFNSARERDKNGDGGPSFASTLIEQQEHHQLSNSDNAWLAATMYAAGSETTAGVLAWWVLAMLMYPETQERAQAELDAVVGRSRLPSFADYDHLPYIRAMVEEALRWRPIDPLGLPHSSTHDDWYRGYFIPAGTIVIPNTWQMNRDIETYGADAEHFNPERYLVSAKSTQSLDGHEGHATYGFGRRVCVGRYVADNSLFIDIAMILWAMDIRRPLEINRRPMTLDLKGCVEDGLVVRPVPFQCQFTPRSPEVLSVLEHARELLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXI1</accession>
    <name>W4JXI1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_429291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550239.1">
        <property type="nucleotide sequence ID" value="XM_009551944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXI1"/>
    <dbReference type="STRING" id="747525.W4JXI1"/>
    <dbReference type="GeneID" id="20674334"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_429291"/>
    <dbReference type="HOGENOM" id="CLU_009568_1_0_1"/>
    <dbReference type="InParanoid" id="W4JXI1"/>
    <dbReference type="OrthoDB" id="3270019at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33266">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33266:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="729" mass="80944" checksum="DEB3CF77F07AED38" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYR8</accession>
    <name>W4JYR8_HETIT</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_386881</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549009.1">
        <property type="nucleotide sequence ID" value="XM_009550714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYR8"/>
    <dbReference type="GeneID" id="20672294"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_386881"/>
    <dbReference type="eggNOG" id="ENOG502QTWN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038732_2_3_1"/>
    <dbReference type="InParanoid" id="W4JYR8"/>
    <dbReference type="OrthoDB" id="10265891at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF31">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW78693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="350" mass="36874" checksum="BD8430E5FF1C4001" modified="2014-03-19" version="1">MSVISTPITQLFGIKHPILLAGMNVAAGPELAAAVTNAGGLGVIGGHGYTPKVLRQQIQAIKKDLKDKNAPFGVDLLIPQVGGNARKTNYDYNKGNLSTLVDIIIEEKAKLFVCAVGVPPKEEVQKLHKAGILVMNMVGHPKHVVKALAAGCDLICAQAGEGGGHTGDIAASILIPACVDAVKGHKSPLTGQPVYVIGAGAVYDGRGLAANLMWGAQGVWVGTRFVASVEAGASPAHKKAVLSAGHGDVLRTIIYTGRPLRVRRTPYVEDWETNRQAEIKELTSKGIIPNELEMEKHPEKSLQAISFLMGNVASLIHDVLPAQEIVNNMVNVAAEQISRGASSITVKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZI0</accession>
    <name>W4JZI0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_419773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548828.1">
        <property type="nucleotide sequence ID" value="XM_009550533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZI0"/>
    <dbReference type="GeneID" id="20673599"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_419773"/>
    <dbReference type="HOGENOM" id="CLU_1749901_0_0_1"/>
    <dbReference type="InParanoid" id="W4JZI0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="149" mass="14966" checksum="79709002D023749D" modified="2014-03-19" version="1">MSPSTIYPSTLPAPSSRPLNLFHVRPALPSDLLSRPALSTPSLAVLPSPLSSHDLMPTGPPAGSPASSTPPTILAYPPPPPPSSTLLPPTPRPPSPPSPPTSPPPPPPPPPPPPPPPHAAPPSPCAPCPAPTAVTATAPRRTAPSPCPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZS1</accession>
    <name>W4JZS1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Cytochrome c oxidase subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Cytochrome c oxidase polypeptide VIIA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">cox9</name>
        <name evidence="14" type="ORF">HETIRDRAFT_50527</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the fungal cytochrome c oxidase subunit 7a family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548785.1">
        <property type="nucleotide sequence ID" value="XM_009550490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZS1"/>
    <dbReference type="FunCoup" id="W4JZS1">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JZS1"/>
    <dbReference type="GeneID" id="20678150"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_50527"/>
    <dbReference type="eggNOG" id="ENOG502SBM8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196969_0_0_1"/>
    <dbReference type="InParanoid" id="W4JZS1"/>
    <dbReference type="OrthoDB" id="2317211at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22888">
        <property type="entry name" value="CcO_VIIa_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014368">
        <property type="entry name" value="Cyt_c_oxidase_su7a_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000283">
        <property type="entry name" value="COX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW79047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="59" mass="7077" checksum="952EF1CA5B0D67C7" modified="2014-03-19" version="1">MPIAPITGKLRKRFWLDLTVAMGLGVSFGYAFWYGVHLKHVQRHEEYYLKLERRRQLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W4K102</accession>
    <name>W4K102_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_324577</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549292.1">
        <property type="nucleotide sequence ID" value="XM_009550997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K102"/>
    <dbReference type="STRING" id="747525.W4K102"/>
    <dbReference type="GeneID" id="20671064"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_324577"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027074_9_0_1"/>
    <dbReference type="InParanoid" id="W4K102"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45948:SF2">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45948">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE DDB_G0269404-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01908">
        <property type="entry name" value="ADSPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="39"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="8">
        <location>
            <begin position="102"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW79015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="238" mass="24840" checksum="2BA5068FBB9C7BD3" modified="2014-03-19" version="1">MLSFSSPSWQSSLISASKASKSPKSASSSKPSVLGSGRAASPILPRLYLSDLFTARSESELTRLGITHVLSIIEHASTFPPSIPLVTAHVAIADVSSEDLLAHFDETTAFIRNALAENEENKVLVHCFMGISRSASVICAYLIATSDMSAAAALAFVKARRGIVSPNAGFVRQLDAYAIRCHNMGGSAKAPRARIGSGVAARIRWLKEAAVGASVSVSAVTALTTPGQNGETVDVANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1J8</accession>
    <name>W4K1J8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multiple RNA-binding domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_445497</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM MRD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548261.1">
        <property type="nucleotide sequence ID" value="XM_009549966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1J8"/>
    <dbReference type="FunCoup" id="W4K1J8">
        <property type="interactions" value="830"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K1J8"/>
    <dbReference type="GeneID" id="20675632"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_445497"/>
    <dbReference type="eggNOG" id="KOG0110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008479_2_1_1"/>
    <dbReference type="InParanoid" id="W4K1J8"/>
    <dbReference type="OrthoDB" id="439639at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12568">
        <property type="entry name" value="RRM3_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12320">
        <property type="entry name" value="RRM6_RBM19_RRM5_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034482">
        <property type="entry name" value="Mrd1_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="105"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="288"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
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        </location>
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        <location>
            <begin position="505"/>
            <end position="582"/>
        </location>
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        <location>
            <begin position="1"/>
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        </location>
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        <location>
            <begin position="594"/>
            <end position="624"/>
        </location>
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            <begin position="13"/>
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        </location>
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            <begin position="24"/>
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        </location>
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        </location>
    </feature>
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            <begin position="76"/>
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        </location>
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            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013428"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW79698.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="624" mass="68928" checksum="AEF4D2070E502F01" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1P5</accession>
    <name>W4K1P5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">D-arabinono-1,4-lactone oxidase</fullName>
            <shortName evidence="11">ALO</shortName>
            <ecNumber evidence="5 11">1.1.3.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">L-galactono-gamma-lactone oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_63784</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23756"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16292"/>
            <dbReference type="ChEBI" id="CHEBI:58277"/>
            <dbReference type="EC" id="1.1.3.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cofactor biosynthesis; D-erythroascorbate biosynthesis; dehydro-D-arabinono-1,4-lactone from D-arabinose: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="20678652"/>
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    <dbReference type="eggNOG" id="KOG4730">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003896_4_1_1"/>
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    <dbReference type="OrthoDB" id="610608at2759"/>
    <dbReference type="UniPathway" id="UPA00771">
        <property type="reaction ID" value="UER00766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0003885">
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
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        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FAD_lactone_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030654">
        <property type="entry name" value="Sugar_lactone_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01678">
        <property type="entry name" value="FAD_lactone_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762:SF1">
        <property type="entry name" value="D-ARABINONO-1,4-LACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="L-GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000136">
        <property type="entry name" value="LGO_GLO"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0274">FAD</keyword>
    <keyword evidence="6 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="12">
        <location>
            <begin position="41"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW79727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4K207</accession>
    <name>W4K207_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_420309</name>
    </gene>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549403.1">
        <property type="nucleotide sequence ID" value="XM_009551108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K207"/>
    <dbReference type="STRING" id="747525.W4K207"/>
    <dbReference type="GeneID" id="20673644"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_420309"/>
    <dbReference type="eggNOG" id="ENOG502R21D">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_657309_0_0_1"/>
    <dbReference type="InParanoid" id="W4K207"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="418" mass="43721" checksum="5F9A8F872CF347A2" modified="2014-03-19" version="1">MQPQPSYQPRPDSRGPQALYARIPEPQANGWNPAVYDQPGYNAYPAPAAAYAPGQEGGYPPTQGPQSMGQPQAPYGDPSLTPAPYGAPQQQQQQQQAAPGGYPQQPYPAQNRMSYFPQQAEHAPSPYGPSQQPQPLAQAQPQPQPQQQVEPPREAQGPPYTFDPKATYPDPNAQAWAQYYAQGGTDPTGAVYFFAVPGITDRTPVDAQSPQAQAQAQVQGQPQSQSQQDAAAGYQQPYAQVQQQSPGAGVVSSTSGLAHSPQSAHPQTAFVQAIQQQQQQPSQPPQAQLQHQPQAQSQPQPQPQPQPQLQDGPQRQASASSLPSPGAYAHELPTPYGAAAPVGPQRQGSLGTAYAPQSPGAAAGAGLGPGVGPAAEWANQYYGLQSQFAGMSVSGQGQGGEHGGQSQAQVPAQPPVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4K264</accession>
    <name>W4K264_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase family 3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_155713</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548429.1">
        <property type="nucleotide sequence ID" value="XM_009550134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K264"/>
    <dbReference type="STRING" id="747525.W4K264"/>
    <dbReference type="GeneID" id="20667591"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_155713"/>
    <dbReference type="eggNOG" id="ENOG502QTNX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008392_5_3_1"/>
    <dbReference type="InParanoid" id="W4K264"/>
    <dbReference type="OrthoDB" id="4215304at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050226">
        <property type="entry name" value="NagZ_Beta-hexosaminidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480">
        <property type="entry name" value="BETA-HEXOSAMINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480:SF16">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 3 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW79892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="464" mass="49608" checksum="3E9090251D8DF99F" modified="2014-03-19" version="1">MALAATCSPDLAERVSAASGRELKLAGINWAYSPVADVNSDSRNPVIGVRSFGDDPHQVGEYVAAVCRGLTSAGVAPSAKHFPGHGDTHVDSHLALPVIQKSGAQLDQTELVPFRAVIHDAASIMTGHMALPKVTGDDTPASLARAATHGLLCDNMGYKGVIVTDCLEMEAVAAREGGVSHAAMDALQAGADVVMVCHRFDRHKGSLEAAYEAVCDGHIPLETLLESGRRVRKMKAQFAGSWDDVLRVPFKKSEWDRLKEANLSLSREAYARSVALVRNPRSVIPLPKRGKVVVLTPVMESLNQAVDDAEGVLRTGDGKLRNTAGPSYLAFTESVKDLVQGDVVHIVYAGGEPLSATQADDVREADAVVFVTRNADRSVWQRKHLTDVLIIRRKQSKPERVVVLASCAPYDLIDMRDEDGLLGGLGYVASFEFTVDALSATAKVIFGEDQAKGRVPVCGGAIMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2L5</accession>
    <name>W4K2L5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_453049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548581.1">
        <property type="nucleotide sequence ID" value="XM_009550286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2L5"/>
    <dbReference type="GeneID" id="20676337"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_453049"/>
    <dbReference type="HOGENOM" id="CLU_921531_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2L5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="302" mass="32435" checksum="B47C8136CF1BC067" modified="2014-03-19" version="1">MQSMCRCLLPPRHLDLLTPRFPSLAFHHPRRPALGSATHPETGSPVAPAARIITVHDARIRARARAAALEIPARRVPPSRRRPAPLRADTQARFKHSIMTRPPCYAATDYTRHLWVIEEAAVPRVGYIRLPGAQTDKQLGTARDCRDPHPNSVTDAGLTPCATFDRSHKPLNDSVVGLSIGTGPDAGHGSGALDTDVELAPCTWYRVSTPLWPPCPTPSGVSRICIMGAARSHFRVSESDAVGRSRTVLVYPASGRRTETGASGQGSAASAPLRAGGSSDVQNLLTERGLPGRLKTMLSALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2W9</accession>
    <name>W4K2W9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_103395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548603.1">
        <property type="nucleotide sequence ID" value="XM_009550308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2W9"/>
    <dbReference type="GeneID" id="20665902"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_103395"/>
    <dbReference type="HOGENOM" id="CLU_1660993_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2W9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW80079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="159" mass="17380" checksum="38ECAA67870B9105" modified="2014-03-19" version="1">MNLSDIILVRSQQASRFSPSLGSRELIYASGADKQRVREADQRRLSTAVFLPKSTECAYSPTSPGGLSTSSAPSALIPHDKHSQSAYGTWTYLDHAEGELVSKRAHSGPDLPPFAWPLTLRRANPALIWARIVKALAPVLGRASRADSRQNLLRFSIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3C7</accession>
    <name>W4K3C7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_475929</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547091.1">
        <property type="nucleotide sequence ID" value="XM_009548796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3C7"/>
    <dbReference type="STRING" id="747525.W4K3C7"/>
    <dbReference type="GeneID" id="20677654"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_475929"/>
    <dbReference type="eggNOG" id="KOG1875">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004632_0_0_1"/>
    <dbReference type="InParanoid" id="W4K3C7"/>
    <dbReference type="OrthoDB" id="205099at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="10">
        <location>
            <begin position="52"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW80328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1220" mass="134122" checksum="784F72EEB1D532EA" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3D2</accession>
    <name>W4K3D2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_319228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547073.1">
        <property type="nucleotide sequence ID" value="XM_009548778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3D2"/>
    <dbReference type="GeneID" id="20670580"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_319228"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_22_0_1"/>
    <dbReference type="InParanoid" id="W4K3D2"/>
    <dbReference type="OrthoDB" id="446925at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="211" mass="23348" checksum="2EAF6FF689BCCC53" modified="2014-03-19" version="1">MGCSPYFAATGTHPLLPLDIAEATYLLPPPTTTLSTTDLIARRAIALQKRRSDLAHLRSSVVGARVQAAIRFEQQHSATLRDFNFHRGSLVLMRNTAIEKALNRKMRPRYLGPLLVISRNQGGAYILAELDGSVFDRPVAAFRIIPYFARRSLKLSDLEALLDISQARLRAMEESRSNDDDAEDDDADEEDTDTSSIRSAEDDDVASATSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3M8</accession>
    <name>W4K3M8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_103705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548239.1">
        <property type="nucleotide sequence ID" value="XM_009549944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3M8"/>
    <dbReference type="GeneID" id="20665926"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_103705"/>
    <dbReference type="HOGENOM" id="CLU_1283403_0_0_1"/>
    <dbReference type="InParanoid" id="W4K3M8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="215" mass="22240" checksum="D2A8503DFD8AFBE3" modified="2014-03-19" version="1">MPFALDPTHPASNRVSVLVLDASNARSHAQAQAHAQAQAQLQAQNHIRTCTAAHDPARKELVALHRAARCFGGPPYLNPAMNAQANANANTNAAAEMYMQMYTQRTQCSAIVFPESARASVKSPARASESSTRPASPRPSTPPRARSGASTESPGARASVSTVGSGSDAGANTSTGTLRRRGSGVTRAWWSGSDASDLSARASVGFEADSARAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3U7</accession>
    <name>W4K3U7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_155685</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF10587">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
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        <location>
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            <end position="218"/>
        </location>
    </feature>
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        <location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="23640" checksum="ABD9098B645FE981" modified="2014-03-19" version="1">MSFDLLKLEAHLAARSYIEGYTPSQADVHVFKALAGVPAAATSPHAFRWYNHIKSYSSEFDSLAGSSTAGEAFTAAPAPAPAAPAAAEEDDDDEVDLFGSDEEDDAEAERVKAERVAAYQAKKANKPKTIAKSVVTLEVKPWDDETDMKALEDSVRSIQQEGLVWGASKLVAVGYGIKKLQITIVIEDELVSLDELQEKVAEFEDYVQSTDVAAMQKL</sequence>
</entry>
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        </lineage>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="ETW80522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="125" mass="14081" checksum="60423FE8F9E6A76C" modified="2014-03-19" version="1">MALLVSDDTVEKLSYFFTEELLLAALDLIDRECVFKYITPWGRTHFQVQGSTEVYTVFPSLSNSPTVPSFCSCPAFSFAVLISNSHLMCKHVLATRLADRLGKCIERHATQDDLVSILSRQYSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="1">SGNH hydrolase-type esterase domain-containing protein</fullName>
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    </protein>
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        <lineage>
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            <taxon>Bondarzewiaceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Yakovlev I."/>
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            <dbReference type="PubMed" id="22463738"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="20670850"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_322385"/>
    <dbReference type="eggNOG" id="ENOG502QUVW">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_867551_0_0_1"/>
    <dbReference type="InParanoid" id="W4K401"/>
    <dbReference type="OrthoDB" id="426133at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052762">
        <property type="entry name" value="PCW_deacetylase/CE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37834:SF2">
        <property type="entry name" value="ESTERASE, SGNH HYDROLASE-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37834">
        <property type="entry name" value="GDSL-LIKE LIPASE/ACYLHYDROLASE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G00620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="139"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="355" mass="39313" checksum="2CA82A17122E6531" modified="2014-03-19" version="1">MVAGHASKSVVIPNTHPLIYYHGRWDKSPGTWWAGSGFKLNVQNLSSLTLNLGSHTTTPLVTVGVSLDYEPFYTVNVSAGTNPIPLTQSSAQAQKSSHTVVRINAVGWQDNRVNLDSITLNSGATLLPYKPSKLAFQYIGDSLSAGQYLPQGVDQAWPFLTGEFFKAEHVVIAQPGAALSDILSYGNVHGLSYQFFKTEDDGFFYTTDHNYTTPWDFRRDVPAATHVVIHIGANDSAQNVTGDAFVDVYLKFLARLRTIYEHQPILVFTPWGWPSADGPNSYYYDGRYSEIVDQRKTLGDHNVFLVNTTGWVTYEDVFPDNLHPSVAGHVKIAGLFERWLGEWGLEPQGAWATPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4B1</accession>
    <name>W4K4B1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_476261</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547314.1">
        <property type="nucleotide sequence ID" value="XM_009549019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4B1"/>
    <dbReference type="STRING" id="747525.W4K4B1"/>
    <dbReference type="GeneID" id="20677668"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_476261"/>
    <dbReference type="eggNOG" id="ENOG502RPVK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010438_0_0_1"/>
    <dbReference type="InParanoid" id="W4K4B1"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW80584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="767" mass="84114" checksum="E23976AF696FAFF6" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4G7</accession>
    <name>W4K4G7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_322484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548467.1">
        <property type="nucleotide sequence ID" value="XM_009550172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4G7"/>
    <dbReference type="GeneID" id="20670860"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_322484"/>
    <dbReference type="HOGENOM" id="CLU_1875701_0_0_1"/>
    <dbReference type="InParanoid" id="W4K4G7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="136" mass="15054" checksum="15417403CC1DAC71" modified="2014-03-19" version="1">MFVHSSSTNLIFSYSRKITPLTDKPTPTIIVSRILTLNSPFPPSLSITMLAAQVTDATDTAKRSKPTRTKRTGKQKPKICASLVVPQINRVCEGAWANDPRRVYEDLAGRGQEHEIGECPACSYNPHHLMFVFAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4J2</accession>
    <name>W4K4J2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_410019</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547389.1">
        <property type="nucleotide sequence ID" value="XM_009549094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4J2"/>
    <dbReference type="STRING" id="747525.W4K4J2"/>
    <dbReference type="GeneID" id="20672825"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_410019"/>
    <dbReference type="eggNOG" id="KOG0549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013615_8_2_1"/>
    <dbReference type="InParanoid" id="W4K4J2"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779:SF7">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845164" description="peptidylprolyl isomerase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="43"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW80669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="140" mass="15109" checksum="C241C18C413B8492" modified="2014-03-19" version="1">MQLFNWLSALAFGLLVSAAEPPTELKIDTTYLPADCSTKAQKGDAIKVHYTGTLFSNGNKFDSSVDRGEPLPLTLGVGQVIRGWDEGLIGMCRNEKRTLTIPSHLAYGSRGFGNVIPANSALVFDVELVGLDTKGPREEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5H9</accession>
    <name>W4K5H9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_452516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547762.1">
        <property type="nucleotide sequence ID" value="XM_009549467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5H9"/>
    <dbReference type="GeneID" id="20676267"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_452516"/>
    <dbReference type="eggNOG" id="ENOG502SAN2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116414_1_0_1"/>
    <dbReference type="InParanoid" id="W4K5H9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="181" mass="19381" checksum="1CA6FE914F0212BB" modified="2014-03-19" version="1">MPLFGSGENTNAAVAERQPSTTPPHSRSSFFARRSHSAERAEAARDTRRSPTSPSTHSSGLFGRRRSVDRDSSDIGRSPTTTSSSSFGGLFGLRHSSSDDSILGRDPSIMSAKKKVQDAEAAEAEADRALHAARMAVREARNHVKILEAEAKDDARRAKAKQEQAKSISKGAKGLGRHGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6R0</accession>
    <name>W4K6R0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit 5, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_445359</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase delta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547710.1">
        <property type="nucleotide sequence ID" value="XM_009549415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6R0"/>
    <dbReference type="FunCoup" id="W4K6R0">
        <property type="interactions" value="278"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K6R0"/>
    <dbReference type="GeneID" id="20675626"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_445359"/>
    <dbReference type="eggNOG" id="KOG1662">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085114_0_0_1"/>
    <dbReference type="InParanoid" id="W4K6R0"/>
    <dbReference type="OrthoDB" id="1262810at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="ATP SYNTHASE DELTA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW81030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="212" mass="22519" checksum="F8994B0B9E3C1D0B" modified="2014-03-19" version="1">MLLSSARSAAASAGLGRRAASTIAVKYAHAAYSAALAKSPQNLSKVQTELNAISKSIKEVPELKSFVSDPTLSVKDRSAGLPALFARAEGTGAKKEQISDTTKNLFALLSENGRLTETEGIIEGFNELVAKYKGELEVVVTSATPLSKDILTRLETTLKQSQTAQQAKSLKLTNKINPSVLGGLVVDFGEKTIDRSVSSRVNKLNSLLQESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6V4</accession>
    <name>W4K6V4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_247806</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546175.1">
        <property type="nucleotide sequence ID" value="XM_009547880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6V4"/>
    <dbReference type="STRING" id="747525.W4K6V4"/>
    <dbReference type="GeneID" id="20669203"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_247806"/>
    <dbReference type="eggNOG" id="KOG1082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2284078_0_0_1"/>
    <dbReference type="InParanoid" id="W4K6V4"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW81538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="102" mass="11779" checksum="425F406703FA013F" modified="2014-03-19" version="1" fragment="single">HRKEAEALDGIEASYIFDLDGREDRDHNGDDADIFSSLQIVYPIDAPLPGNWTRFVNHSCEPNMRIYCVVFDTIPEMNRPFHAFYALKDIPAFTELTIDYNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7Q2</accession>
    <name>W4K7Q2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C4-dicarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_173063</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546031.1">
        <property type="nucleotide sequence ID" value="XM_009547736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7Q2"/>
    <dbReference type="GeneID" id="20668419"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_173063"/>
    <dbReference type="eggNOG" id="ENOG502QT02">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030057_6_0_1"/>
    <dbReference type="InParanoid" id="W4K7Q2"/>
    <dbReference type="OrthoDB" id="1099at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000319">
        <property type="term" value="F:sulfite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09318">
        <property type="entry name" value="TDT_SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051629">
        <property type="entry name" value="Sulfite_efflux_TDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686:SF3">
        <property type="entry name" value="ACID TRANSPORT PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G09410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW81380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="421" mass="47000" checksum="FBD9FB87588BEEBD" modified="2014-03-19" version="1">MLPSTSKLLKDRVRHFVPAWFAVIMGTGSISILFQKFPYWNGTATMNALSALFFFLNFVLFVVIMITSVVRYIIFPDIWFIMVRHPVQSLYLGCFPMGISTLLNVSVSLLYKEYGFGGTTFLYTIWGFWWLNVAISILCCWGMVHVMSTTHDHSLNQMSSVWLLPVVTLIVTSSSGGILAQAIQPLSPSHALLTTTFSVFLVSIGLSLALMILTIYFYRVILHGPPRGANVISTFVPLGPTGQAGFSMILIGENTKELFPIANSASPFMSNTNAGEIIYTVCVCIAFVLWSLATMWLVFALLSIQSVVRRTRFPFRIPFWGMIFPNGVYANLTIMLYRVLDVRFFRVWGAVYAVLTLVAWSVVFIRTVSMVRTGEIFAAPCLEDIDMGVSVGNPREREREEGQVQAQASQSQATSCAQQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4K864</accession>
    <name>W4K864_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mon2/Sec7/BIG1-like HUS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_247126</name>
        <name evidence="3" type="ORF">HETIRDRAFT_247127</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545930.1">
        <property type="nucleotide sequence ID" value="XM_009547635.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551818.1">
        <property type="nucleotide sequence ID" value="XM_009553523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K864"/>
    <dbReference type="GeneID" id="20669146"/>
    <dbReference type="GeneID" id="20669147"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_247126"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_247127"/>
    <dbReference type="eggNOG" id="KOG0929">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2928954_0_0_1"/>
    <dbReference type="OrthoDB" id="3260456at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HUS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW76960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW81256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="61" mass="7091" checksum="C93B1C178915E57E" modified="2014-03-19" version="1" fragment="single">MTINDLFLKDAFVVFRSTCKLTMKPLNTESERDLKSHAMRSKLLSLYMVLIILNAHMDVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8A6</accession>
    <name>W4K8A6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_426755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545949.1">
        <property type="nucleotide sequence ID" value="XM_009547654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8A6"/>
    <dbReference type="GeneID" id="20674142"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_426755"/>
    <dbReference type="HOGENOM" id="CLU_1635618_0_0_1"/>
    <dbReference type="InParanoid" id="W4K8A6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="162" mass="17869" checksum="4941369512A8D304" modified="2014-03-19" version="1">MCPGPESDNRSKAITIDSRRIIGLWRAQSLRAVLCLTYVANYVRAHASEYEVSFLVTAVVAGGVLGVLHLDGQPLVKQIEFLHREEDVERLLCAAADAASRSFEWHNDQWLNNNILNEILRVRQGAPAEYRDVADAGGPEAHSSAMEVAASQQADEVDKDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8P2</accession>
    <name>W4K8P2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_475183</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546329.1">
        <property type="nucleotide sequence ID" value="XM_009548034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8P2"/>
    <dbReference type="FunCoup" id="W4K8P2">
        <property type="interactions" value="195"/>
    </dbReference>
    <dbReference type="GeneID" id="20677608"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_475183"/>
    <dbReference type="eggNOG" id="KOG1313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054274_1_0_1"/>
    <dbReference type="InParanoid" id="W4K8P2"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="132"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW81715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="339" mass="38385" checksum="3BF2CEF9F078247C" modified="2014-03-19" version="1">MSCPRAVFRCFRALERFGDRVTGAAGPYFVAFAVLLIASGALSFLEVVLPNLPWPWLATPPCLLLALNLFAHYYYVCTVPPGFVDAPPPPHPRGLLWAPRPDAADPPRQHPDRGVRWSASAPLVVTPAAVTTCRKCGQKKPERTHHCRICNRCVLKYDHHCPVRINQCVGLYNERHFVLFMAYLVLATFFFAILGFPYLLDALGLRYDDNWGYRTPAVVFIMAWVLSAVMCLAVGTMLAWHLWSVAQGETSVEGHDHDVYRRVARERGETFVNSYDLGKRQNLALFLHLGPMGYPWYTLVLPLRTLPYTDGRAWARKPGHERHRGVRAGEELTDEEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4K944</accession>
    <name>W4K944_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase family 15 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_317287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546237.1">
        <property type="nucleotide sequence ID" value="XM_009547942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K944"/>
    <dbReference type="STRING" id="747525.W4K944"/>
    <dbReference type="GeneID" id="20670409"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_317287"/>
    <dbReference type="eggNOG" id="ENOG502SBKB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065187_0_0_1"/>
    <dbReference type="InParanoid" id="W4K944"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844359" description="Glycosyltransferase family 15 protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="40711" checksum="B5A14AF4ADF84FFA" modified="2014-03-19" version="1">MTPSAGLLFGCGVASWASVLYVLRESDAEDDTHTQVRPPPSLPRAFLHRFSSHREQQDRAPHGRARRIVGGAVFAALILSSAYGTSQITSTPSIRPLSVADVIAAPPQPACARRPLAFAPLHSPDARAYREFDDVLLVVFFSHARYDVNLDYYRAVYAEYFPNMLFIGPGSREDAGFRHSYDVLVDSYESDEDLSDPGFYKMAGRMAHHMLYTALQEHPCYAGYLWAPFDTLLNVPRLQQFDQNLFWYHSPFARYVPNAALGSEEANAERGRHAPPANISPDPYLNLTEGWRGWGPDWCDPHVGVSKWAQGMEVDTFHTFHWGDKDESGEWRGNPAHITDVRRLLQESAARQEIAFPGPSSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9H5</accession>
    <name>W4K9H5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_165233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544797.1">
        <property type="nucleotide sequence ID" value="XM_009546502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9H5"/>
    <dbReference type="STRING" id="747525.W4K9H5"/>
    <dbReference type="GeneID" id="20667972"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_165233"/>
    <dbReference type="HOGENOM" id="CLU_046876_0_0_1"/>
    <dbReference type="InParanoid" id="W4K9H5"/>
    <dbReference type="OrthoDB" id="312874at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="159"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW82433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="466" mass="53139" checksum="EBC5482A516FB4E1" modified="2014-03-19" version="1">MAKDDVQDNFWTIETDTFLDHVLGWKTADNNVRNVLHTLNSSSAQWLSLPKVPKLEKELYSSFADTANAIIAACSATNPIVELALDISWQAGPNKSPKSPDRWSPQIRPDSLAVIGLKDALDEFKRLDTRIQDLEHQLGSGPEEEAEKEDLKLQRKEVLKKCELWWLRVHIPVEMKLKNSKEEMLEGILQLCSYMWMVLAEQLDRRFAIGLLLCKSKLTVWMCDRSGLVGTRTAIDIHAEPKKFIKVIISLSRLNPSRLGWDTTMRIYRMETATYHFSTDKDVTVDYYGVSPHETTWAIQGPRSDGNEGKDRYLTVKALSTVQAQVMEGRATIVWLVVNERTMERFVLKQSWRPEMLQTEATFHKFLSKPPSIHICDIVNSVDIRVMDDEQGGMVVNNTVNHIRCSVEVQASSLKRSKLPKDPGASELRSTKRKKPELDESQPHESFLHVTLTSSEVLKFPVIADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9N0</accession>
    <name>W4K9N0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_382643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544902.1">
        <property type="nucleotide sequence ID" value="XM_009546607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9N0"/>
    <dbReference type="GeneID" id="20672126"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_382643"/>
    <dbReference type="HOGENOM" id="CLU_1272449_0_0_1"/>
    <dbReference type="InParanoid" id="W4K9N0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="217" mass="23896" checksum="DA79BA0680CBF5A8" modified="2014-03-19" version="1">MADRRAVSLFVADGGADIQCLRRRGRGPVSDPRNGRLFELREPHLPHRRIAAVKLRRTASQIPPTSVSSLCAPRAFQGFGIDTLLPTVGSQATTIFDQGAAPSRFPAAARIRKWCMHPLSGVHWPSPCRLRPCPCHRSGARAARPLLDSALRRQRTGHVGRGEIMSVLACSCNGAVSAHVWAAGRGDERRHTRGIDGRTYVVQGHRRARSRWVIVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9V6</accession>
    <name>W4K9V6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_382653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544918.1">
        <property type="nucleotide sequence ID" value="XM_009546623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9V6"/>
    <dbReference type="STRING" id="747525.W4K9V6"/>
    <dbReference type="GeneID" id="20672128"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_382653"/>
    <dbReference type="eggNOG" id="ENOG502QTM3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1170407_0_0_1"/>
    <dbReference type="InParanoid" id="W4K9V6"/>
    <dbReference type="OrthoDB" id="5594178at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990304">
        <property type="term" value="C:MUB1-RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051664">
        <property type="entry name" value="MYND-type_zinc_finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442:SF1">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="198" mass="21838" checksum="F4E6E990502243FA" modified="2014-03-19" version="1" fragment="single">MRESNFAFPAQNRASVCISSQLYDRRALDTNSSLPLFNSLTHLTYLTATSPRIREIMTMDGGLERLVRLLHDFCLSPPPPENPAVLYGLLPPAHRAPRLAPALNPKVFDKHAAYRFSLAFQCVVNIGVRGSEPIRSRVVQAGTLDVVGCILEAWLANKGFAVGPSSSASGMPRESREQRVARRLAQAEQRSREQAAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAG8</accession>
    <name>W4KAG8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_163229</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545129.1">
        <property type="nucleotide sequence ID" value="XM_009546834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAG8"/>
    <dbReference type="GeneID" id="20667831"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_163229"/>
    <dbReference type="eggNOG" id="ENOG502S3G3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_676251_0_0_1"/>
    <dbReference type="InParanoid" id="W4KAG8"/>
    <dbReference type="OrthoDB" id="8955945at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW82807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="406" mass="45438" checksum="25C25A576AC07746" modified="2014-03-19" version="1">MSGQASTSTDPPSATVQPGRGKVKLPDNYTGNCIKSQKFMLQCLLFTAESDRYKTDQDKISLVLSCMRYGTAGAWAENFLLKSVGADPPTDLGTWRDFLTKFKLQFRETGKTNKARSALMAFSQGQMTVDEYSNQFILIAADADISDKEQVPYFQRGLDPRVMDKIYDKEVQPKDTIQDWINTACEIDERLRARSAQKAILANSTSFRSNYLNRFHTQPAVCYNSTTAPRRMNNQVVDMDIDATRKRNAKSQKRKFDGKRTPSCSNCGKLGHSGANCWSARRGVQPVRGNSKRRLGMTGRRNHAVDLEEEDDAPAMGNQAGIHWRMETENVHRNNQRVPQPGPSMERPHSAPSGRPQTDHQRRIMLPDGRRGNGGVSHSARIGAVLGELGEDEAREVILGHAERFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAH7</accession>
    <name>W4KAH7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate dehydrogenase assembly factor 3</fullName>
            <shortName evidence="6">SDH assembly factor 3</shortName>
            <shortName evidence="6">SDHAF3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_433628</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the complex I LYR family. SDHAF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545103.1">
        <property type="nucleotide sequence ID" value="XM_009546808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAH7"/>
    <dbReference type="FunCoup" id="W4KAH7">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KAH7"/>
    <dbReference type="GeneID" id="20674684"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_433628"/>
    <dbReference type="eggNOG" id="KOG4100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102310_1_0_1"/>
    <dbReference type="InParanoid" id="W4KAH7"/>
    <dbReference type="OrthoDB" id="278329at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006105">
        <property type="term" value="P:succinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20270">
        <property type="entry name" value="Complex1_LYR_SDHAF3_LYRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008381">
        <property type="entry name" value="SDHAF3/Sdh7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137">
        <property type="entry name" value="DC11 ACN9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137:SF6">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW82778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="146" mass="16603" checksum="2ABE5B2C56796B77" modified="2014-03-19" version="1">MRATLLRLAESVTTRPLNLRAASATLLPPIPLYRRLLRAHRYLPVEMRSLGDDYVKSEFRRHKDVDNPAYLIGFLSQWKSYLDQIPAGPEAQQFKGRKMDPTVFEKLSSEQLGQMYELMHATKDVWKPANELAESPTGSGKDGSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAI5</accession>
    <name>W4KAI5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_247615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009546849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAI5"/>
    <dbReference type="GeneID" id="20669184"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_247615"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_6_4_1"/>
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    <dbReference type="OrthoDB" id="2630497at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="1">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="103" mass="12272" checksum="3C3B784E9C8E92A6" modified="2014-03-19" version="1" fragment="single">HPKFKLAPRRYGPFKIIAKLRTLAYKLQIPQHWKIHPVFHATMLTRYKETEARGGDFARPLPEILNNEEHYEVEIIVDSKKHGWGTKYLVKWMGYPKADNTWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAU7</accession>
    <name>W4KAU7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_18769</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544607.1">
        <property type="nucleotide sequence ID" value="XM_009546312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAU7"/>
    <dbReference type="GeneID" id="20668630"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_18769"/>
    <dbReference type="HOGENOM" id="CLU_082854_6_2_1"/>
    <dbReference type="InParanoid" id="W4KAU7"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051356">
        <property type="entry name" value="SOX/SOX-like_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789:SF2">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW82913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="74" mass="9039" checksum="EF24168CCE70C88F" modified="2014-03-19" version="1" fragment="single">IKRPLNAFMLFRKQFVAQRRDMLMMIEKDHRKLSEMAGKMWRDMTMAERQPWFAASEVEKVAHDQKYPDYKFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAW4</accession>
    <name>W4KAW4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_316269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545232.1">
        <property type="nucleotide sequence ID" value="XM_009546937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAW4"/>
    <dbReference type="STRING" id="747525.W4KAW4"/>
    <dbReference type="GeneID" id="20670310"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_316269"/>
    <dbReference type="eggNOG" id="ENOG502SD4X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074862_0_0_1"/>
    <dbReference type="InParanoid" id="W4KAW4"/>
    <dbReference type="OrthoDB" id="424402at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="207" mass="23400" checksum="065833CCB8307039" modified="2014-03-19" version="1">MASAVPPTVSNEATEPAYDFHEMRITNHGKINAWVDFALQFFEANEAKALVLHTLPITAQASATSKPGPTRNVSLPTTTIPRLISVVEIIKREYLKMMNEKMWPGMEGLHQYNEIGCLEDMDEWNVPIQEQSVEDRASELISALGGTKNVREKRTAYMKVTLCRQEIPNLGGNGATYQRPMKRKLTKSAKGRLKKRLKKQTERVEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4KB02</accession>
    <name>W4KB02_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_416935</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pICln (TC 1.A.47) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545206.1">
        <property type="nucleotide sequence ID" value="XM_009546911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KB02"/>
    <dbReference type="STRING" id="747525.W4KB02"/>
    <dbReference type="GeneID" id="20673374"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_416935"/>
    <dbReference type="eggNOG" id="KOG3238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077804_3_0_1"/>
    <dbReference type="InParanoid" id="W4KB02"/>
    <dbReference type="OrthoDB" id="19714at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034709">
        <property type="term" value="C:methylosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006821">
        <property type="term" value="P:chloride transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003521">
        <property type="entry name" value="ICln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039924">
        <property type="entry name" value="ICln/Lot5/Saf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399">
        <property type="entry name" value="CHLORIDE CONDUCTANCE REGULATORY PROTEIN ICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399:SF0">
        <property type="entry name" value="METHYLOSOME SUBUNIT PICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03517">
        <property type="entry name" value="Voldacs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01348">
        <property type="entry name" value="ICLNCHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW82899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="205" mass="22707" checksum="1F40F3EF669F9919" modified="2014-03-19" version="1">MPPITLISSLPPYISPEEHAQITVSTPASFSDIPSVLRHKEENVSAILTPPVEDFSAEDGAQGTLYVIDSALVFLSSTGRGFQVEYPFITIHALSLDETRRSVYCQLDDPSVPELNDGIPNLRELFIKTQNPSSLEAIYESLSYCVSLHPSVLDEEDDRDDAFIDSNSFETFTGDEDEELSEVGRAALAHLESIIDYPNEHTNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4KB94</accession>
    <name>W4KB94_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DyP-type peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">dpx1</name>
        <name evidence="11" type="ORF">HETIRDRAFT_40020</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544629.1">
        <property type="nucleotide sequence ID" value="XM_009546334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KB94"/>
    <dbReference type="STRING" id="747525.W4KB94"/>
    <dbReference type="GeneID" id="20672508"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_40020"/>
    <dbReference type="eggNOG" id="ENOG502RUI2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015125_2_0_1"/>
    <dbReference type="InParanoid" id="W4KB94"/>
    <dbReference type="OrthoDB" id="3207336at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049509">
        <property type="entry name" value="DyP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048328">
        <property type="entry name" value="Dyp_perox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30521:SF4">
        <property type="entry name" value="DEFERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30521">
        <property type="entry name" value="DEFERROCHELATASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21105">
        <property type="entry name" value="DyP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20628">
        <property type="entry name" value="Dyp_perox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="DyP dimeric alpha+beta barrel" evidence="10">
        <location>
            <begin position="13"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Dyp-type peroxidase C-terminal" evidence="9">
        <location>
            <begin position="240"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW82635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="489" mass="53465" checksum="E9FCA220DA5346F0" modified="2014-03-19" version="1">MTTHTPAPLNLANVQGDILAGLPKKTQTYVLFEITDAQAFRTALTHLIPLITSTEQVKKDRHSIDENKKTAAHSGHPPPLLDIVGVNVSFSQLGLNKLGIKDDIKDAVFKAGQLSDAQNLGDPGTTNASKKFVPDWIDAFKKGVHGVFIVSGSCHELVSKKVEEIEHIFGVHGHHASYTQLLSIVGDVRPGKEKGHEHFGFLDGISQPAVKGIDTDPNPGQETIRQGIMLLGRDGDDVAAQRPSWALDGSFLAFRYLFQLVPEFNKFLHDNPIDLPGLTRAEGSELLGARFMGRWKSGAPIDISPLKDDPALATDPKKNNNFRFQGEANSQTRCPFSAHVRKTNPRADLEDTKPPNSTENRRIIRRGVQFGPELTAEEQHANKTIHGRGLIFAAYQANIANGFQFIQHSWANNQKFIFGTTVEPGFDPIIGQAGSDGARTVSGSNPKAQANMLTLPTQWVVPKGGEYFFSPSIPALRDTFALGVHIESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBF7</accession>
    <name>W4KBF7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_474203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545348.1">
        <property type="nucleotide sequence ID" value="XM_009547053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBF7"/>
    <dbReference type="FunCoup" id="W4KBF7">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KBF7"/>
    <dbReference type="GeneID" id="20677554"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_474203"/>
    <dbReference type="eggNOG" id="KOG2128">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009455_0_0_1"/>
    <dbReference type="InParanoid" id="W4KBF7"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
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            <end position="382"/>
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            <begin position="40"/>
            <end position="67"/>
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    </feature>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW83064.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="771" mass="88117" checksum="E3C80B7B385A8C59" modified="2014-03-19" version="1"> </sequence>
</entry>
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_458578"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
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            <end position="255"/>
        </location>
    </feature>
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        <location>
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            <end position="341"/>
        </location>
    </feature>
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        <location>
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            <end position="575"/>
        </location>
    </feature>
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            <end position="31"/>
        </location>
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            <end position="57"/>
        </location>
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            <end position="80"/>
        </location>
    </feature>
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        </location>
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            <end position="122"/>
        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="ETW83006.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDR5</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <lineage>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
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                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHAF1 family.</text>
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    <dbReference type="GeneID" id="20669969"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_312592"/>
    <dbReference type="eggNOG" id="KOG2819">
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00024339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="388" mass="43338" checksum="35DA91940305AE2F" modified="2014-03-19" version="1">MFSALDLDIRPGDGLGIFTLGALLPSPGSSLWTVLDVLRTHQHTFPQIDLKYDPDSPTTPIILHARPHLDLLFSAIHQRLHTISIRRLRDPHRPLTLRYKNAVLSSTDNDLRRVGVSRAFGPTYPGPDLRYPGISFSFDDEGLSDALSPPSNVPEGRMQEVKRILIAQTSPVDDGAERDALGEVDVCPAMHGELAQATLKVHDGVVLRFYPASTDPVRVRLGVTTAQDLMCELGPPLRTFYKEDDRMAIHARNPPLDPHSDPSYFYNYFQHGIDFLISGTTHVVIKIVLHTNIPGTPLFQRYKRCPWQIEGRPEDDEDDSPPCVRFDERVETISHFLCPGQTPPSMHFNRTDDEDALTLPSPTTRLLGFDGIILEATESAQVVSVTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDR7</accession>
    <name>W4KDR7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545494.1">
        <property type="nucleotide sequence ID" value="XM_009547199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDR7"/>
    <dbReference type="GeneID" id="20673390"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_417191"/>
    <dbReference type="HOGENOM" id="CLU_003921_3_0_1"/>
    <dbReference type="InParanoid" id="W4KDR7"/>
    <dbReference type="OrthoDB" id="3252634at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="247" mass="28044" checksum="1839231C38B74F28" modified="2014-03-19" version="1">MATPSMPARGDRTAPTFDPHQPRELRRYFSDLDFHFGRSAVGDEQERKKHACRFLDVDTCELWESLTTFTDATKTFKDFCEEVYRLYPGSEEERKWSVSDMDKLVGETSRVGILSLSELGDYHRRFLVITVFLLSKARISVAEQGRAFARGFQLELWARISQHLQLKFPDHFPDDPYNLQDIHDAARFVFHGTTAAYSATPTDISRAAPAAPPTNAIKAEDLATMFERLTDTFVKAITAQGTSRPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDT0</accession>
    <name>W4KDT0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_417196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545503.1">
        <property type="nucleotide sequence ID" value="XM_009547208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDT0"/>
    <dbReference type="STRING" id="747525.W4KDT0"/>
    <dbReference type="GeneID" id="20673393"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_417196"/>
    <dbReference type="HOGENOM" id="CLU_1294561_0_0_1"/>
    <dbReference type="InParanoid" id="W4KDT0"/>
    <dbReference type="OrthoDB" id="73076at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW83226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="213" mass="24011" checksum="0AD88753558AE8C3" modified="2014-03-19" version="1">MKYLNTHYRDKGSAIVYAKALGLQDIFEEVNQKSIYVRYVKGVLKGEYDDHRVFNGLLAAIVDGRECSQAGKGLQNMQYAPSLDKFSHIALIESPGVYRFMAQHFNLHSARSFKMKQAAMPRFPSTISAATYDCVRHMLKALDYNGPLGISCDDTKLHATLRTYWDSQADQHFLVGHTGDPMPIANPQELQEILRSAELEKATKLWPSTSLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KE85</accession>
    <name>W4KE85_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_439044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543868.1">
        <property type="nucleotide sequence ID" value="XM_009545573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KE85"/>
    <dbReference type="GeneID" id="20675100"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_439044"/>
    <dbReference type="HOGENOM" id="CLU_1992916_0_0_1"/>
    <dbReference type="InParanoid" id="W4KE85"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="125" mass="13617" checksum="04D15E5C6D6FC743" modified="2014-03-19" version="1">MDELSVIQFKPLEVSEPAQSPGPEPVLEPEPESQDQSHPPVVRLPPLSHSPPPVHSPDHLPSHLPAAESDVMMADEDESRQVLSLVPMDNSTQTSITEPMEAEQLDDSLDMDAEGEIDDEVAIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEF3</accession>
    <name>W4KEF3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein AF-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">YAF9</name>
        <name evidence="6" type="ORF">HETIRDRAFT_312423</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for an H2A variant leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SWR1 chromatin-remodeling complex and of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">The coiled-coil domain is required for assembly into the NuA4 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YAF9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543826.1">
        <property type="nucleotide sequence ID" value="XM_009545531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEF3"/>
    <dbReference type="FunCoup" id="W4KEF3">
        <property type="interactions" value="426"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KEF3"/>
    <dbReference type="GeneID" id="20669955"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_312423"/>
    <dbReference type="eggNOG" id="KOG3149">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051385_2_1_1"/>
    <dbReference type="InParanoid" id="W4KEF3"/>
    <dbReference type="OrthoDB" id="16041at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16908">
        <property type="entry name" value="YEATS_Yaf9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23195">
        <property type="entry name" value="YEATS DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YEATS" evidence="5">
        <location>
            <begin position="54"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="279"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW84119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="317" mass="35111" checksum="140F0E7530ADFB0C" modified="2014-03-19" version="1">MHGERSLNGGVRERRGGSGAFWLQQPAWPTTASAQRSVPVPSPLSPSPTTHPHPPQGITIHRPIIYGNTAVVLTQKDREQLPSPDHTHRWTVAVRSAASLPDSPIVGGADDISYFVKRVTFKLHDTYANPTRNIDKPPFEVSETGWGEFEVQIRIHFLPDSGEKPIMLYHHLKLHPWPSAAPTAPTASTAPGAAAPEPDAAPHPDLALLHGPVHSWQYDELLFFDPFQSFLNILLAHPPTALPKAKTRPAPFNGVLPALYEPAKGATPEFTAVMEAEEIDRLEAARKEVVAEHERWRVRLLEKEAELERLKRELSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEH2</accession>
    <name>W4KEH2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_149248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545707.1">
        <property type="nucleotide sequence ID" value="XM_009547412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEH2"/>
    <dbReference type="GeneID" id="20667333"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_149248"/>
    <dbReference type="HOGENOM" id="CLU_2171405_0_0_1"/>
    <dbReference type="InParanoid" id="W4KEH2"/>
    <dbReference type="OrthoDB" id="432299at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW83461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="110" mass="12887" checksum="263A3DB2B4DCBBE7" modified="2014-03-19" version="1">MWTMQTRWPEQRPLMIQLHPDEPDEFTWWPTDLTPDTPLDITASIRAGENRLRIVQLDGMSDCVFVLHAGYPDEQQIKAVADHRRRDVEWNQMVVRMSLRSGTIVFPNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFD5</accession>
    <name>W4KFD5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">assimilatory sulfite reductase (NADPH)</fullName>
            <ecNumber evidence="4">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HETIRDRAFT_382156</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="4"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544210.1">
        <property type="nucleotide sequence ID" value="XM_009545915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFD5"/>
    <dbReference type="FunCoup" id="W4KFD5">
        <property type="interactions" value="250"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KFD5"/>
    <dbReference type="GeneID" id="20672106"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_382156"/>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003662_0_0_1"/>
    <dbReference type="InParanoid" id="W4KFD5"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06207">
        <property type="entry name" value="CyPoR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000010">
        <property type="entry name" value="Sulfite reductase [NADPH] flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF109">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] FLAVOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="674"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETW84553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1059" mass="114792" checksum="519E8F33B1ED6F46" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFF3</accession>
    <name>W4KFF3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_312736</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544225.1">
        <property type="nucleotide sequence ID" value="XM_009545930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFF3"/>
    <dbReference type="FunCoup" id="W4KFF3">
        <property type="interactions" value="424"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KFF3"/>
    <dbReference type="GeneID" id="20669977"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_312736"/>
    <dbReference type="eggNOG" id="KOG0174">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_5_2_1"/>
    <dbReference type="InParanoid" id="W4KFF3"/>
    <dbReference type="OrthoDB" id="7854943at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03762">
        <property type="entry name" value="proteasome_beta_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000010">
        <property type="entry name" value="Proteasome subunit beta type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW84573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="233" mass="25215" checksum="B2A8167031F9AA04" modified="2014-03-19" version="1">MDHPDMQRLKSGEVNLGTSIMAVQFDGGVIVGADSRTTTGSYIANRVTDKLTYVHDRIYCCRSGSAADTQAIADIAHWYLQIYTQEAQTPSVYTAATVFEKMCYDNKDALSAGIIVAGWDKEVGPSVYNIPLGGGLFRQPWAIGGSGSTYVYGYCDATYQEGWGKEQTVQFVKNTLSLAMSRDGSSGGVIRMAIITEDGVERLFVPGNELPTFWEGHDVLGASKTIPAPMAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFG3</accession>
    <name>W4KFG3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_438993</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543771.1">
        <property type="nucleotide sequence ID" value="XM_009545476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFG3"/>
    <dbReference type="STRING" id="747525.W4KFG3"/>
    <dbReference type="GeneID" id="20675091"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_438993"/>
    <dbReference type="eggNOG" id="KOG1711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085461_0_0_1"/>
    <dbReference type="InParanoid" id="W4KFG3"/>
    <dbReference type="OrthoDB" id="416470at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047867">
        <property type="entry name" value="Ribosomal_uL22_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="CHLOROPLAST 50S RIBOSOMAL PROTEIN L22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL22M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW84055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24455" checksum="EA53970A0EEB1667" modified="2014-03-19" version="1">MNPLDWFRRQINPTVRDRKSNADIEVAKRKQAEEGTLSVFDSSAAATEDKKPAAAKDTSMVVKTRSDHHKYSTANFKISHRKLNKIGRQISGKPIDSAILQMTFSEKRASKRIRNMLVVAKSHAAMKGMDEKKLIVSESWVTKGPRSHKRLEPRGRGKHGIRVHPDSRMSVILKEGKTREQLLAEDRARKLKRIVSAGLVREDVPLRNPASMWTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFJ6</accession>
    <name>W4KFJ6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_314137</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544278.1">
        <property type="nucleotide sequence ID" value="XM_009545983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFJ6"/>
    <dbReference type="GeneID" id="20670094"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_314137"/>
    <dbReference type="eggNOG" id="ENOG502S3G3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_676251_0_0_1"/>
    <dbReference type="InParanoid" id="W4KFJ6"/>
    <dbReference type="OrthoDB" id="8955945at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="277"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW84632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="407" mass="45499" checksum="E670D3B5D7D7C8AA" modified="2014-03-19" version="1">MSGQASTSTNTPSATVQPGRGKVKLPDNYTGDRIESQKFMLQCLLLFAAESDRYKTDQDKISLVLSCMRYGTAGAWAENFLLKSVGADPPTDLGTWKDFLAKFKLQFRETGKTDKARSALMAFSQGRMTVDEYSNQFILIAADADISDKEQVPYFQRGLDPRVMDKIYDKEVQPKDTIQDWINTACEIDGRLRARTAQKAILANSTSFRSDYLNRFHNQISPRYNSTNAPRRMNNQVVDMDIDATRKRNALSQKRKYDGKPPSACYHCGKTGHWNTDCPSRRRGVQPTRGNSKRRMGTTGRRSRVVDLEGEDDAPAMGNQAGIYRGMETEDVPRNDQRVPQPGPSMERPHSTSPGRPQTNHGQRAMLPNGRRGDGSVSHSARIGAVLGELGEDEAREVILGHAERFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGC3</accession>
    <name>W4KGC3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">holo-[acyl-carrier-protein] synthase</fullName>
            <ecNumber evidence="1">2.7.8.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_458147</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.8.7" evidence="1"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544026.1">
        <property type="nucleotide sequence ID" value="XM_009545731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGC3"/>
    <dbReference type="STRING" id="747525.W4KGC3"/>
    <dbReference type="GeneID" id="20676889"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_458147"/>
    <dbReference type="eggNOG" id="KOG0945">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_765169_0_0_1"/>
    <dbReference type="InParanoid" id="W4KGC3"/>
    <dbReference type="OrthoDB" id="26719at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050559">
        <property type="entry name" value="P-Pant_transferase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215:SF10">
        <property type="entry name" value="L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215">
        <property type="entry name" value="PHOSPHOPANTETHEINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="4">
        <location>
            <begin position="140"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="28"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW84345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="362" mass="36835" checksum="29C146D648A58946" modified="2014-03-19" version="1">MEIWIVTDAASLDPRLYDAGLALLDPASADRTPAVSPPAPAPPRPRVPDPLPPQAVSSAASSRASSSPPPAPSHPPTSPSPTPPPANPTTQTTPGLDPPLAFNVSHDGAAVAMAFAPDPRPIPADLGARADSDAVRAGLVGVDVMRVAVPHRTTFRELVRGVGDTLTPRERAQLAPPTPERTARRRFFWMWTLKEAFAKARGAGLAFELRRIECDVRAVRSGVPREETGAAVRVTVDGAPPRGWAFVLFEFDAPHAGAGAGADAGADVDVGAGGDADADAGQARYQGVAARFVGGDAPPTFVVRRVGGSRLDARADGADGAGAEVVYRDEADALVERAVRVLGGGGGGGDGGGDGGAGAAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGT8</accession>
    <name>W4KGT8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">KRR1 small subunit processome component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">KRR-R motif-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_103077</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Essential for vegetative growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3. Interacts with MPP10, KRI1 and with ribosomal proteins RPS1A, RPS4A, RPS4B, RPS8A, RPS8B, RPS11A, RPS11B, RPS13, RPS24, RPS25, RPL4A, RPL7B, RPL8, RPL23, RPL25 and RPL28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the KRR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544191.1">
        <property type="nucleotide sequence ID" value="XM_009545896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGT8"/>
    <dbReference type="FunCoup" id="W4KGT8">
        <property type="interactions" value="668"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KGT8"/>
    <dbReference type="GeneID" id="20665870"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_103077"/>
    <dbReference type="eggNOG" id="KOG2874">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040185_0_2_1"/>
    <dbReference type="InParanoid" id="W4KGT8"/>
    <dbReference type="OrthoDB" id="441223at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000011">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000014">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006515">
        <property type="entry name" value="KRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 11" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="K Homology" evidence="13">
        <location>
            <begin position="141"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="250"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="252"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW84530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="396" mass="45355" checksum="758855594D012600" modified="2014-03-19" version="1">MASEGDDTVVVNKNKRFRKEKPHFTRALSPSTYAYQNSWKVDPFTAADNKGGTFTEESSFATLFPKYREKYLREAWSAVTRALDPHGISCQLDLIHGSMSVRTTRKAYDPYVILKARDMIKLLARGVAVGQAVKILDDNVACDIIKIGNVVRNKERFVKRRQRIIGPDGSTLKAIELLTQCYVLVQGSTVSVMGPYKSLKEVRRIVLDCMKNIHPIYRIKELMIKRELAKDPKLAEESWDRFLPQFRRKHLKTSEKTARKNDKVEAKNEARKAAGVEPEPAQKPEKKVYTPFPPAQQPRKIDLQLESGEYFLQPHEKKRREDRERMQKQTEVSAKRRAERAEAFVAPVEEAAPTVEEKRKRKRQEGESGAVEAPSREDKDGKKKKKKARFAAEGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGW0</accession>
    <name>W4KGW0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_101134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541984.1">
        <property type="nucleotide sequence ID" value="XM_009543689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGW0"/>
    <dbReference type="GeneID" id="20665735"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_101134"/>
    <dbReference type="HOGENOM" id="CLU_678037_0_0_1"/>
    <dbReference type="InParanoid" id="W4KGW0"/>
    <dbReference type="OrthoDB" id="3257151at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="45210" checksum="3BA369040A4621E4" modified="2014-03-19" version="1">MAPLAHLGNRLTSHQIAELCEFWASEQGVPSLESRRAWSLAHQIDPSIVNKWFSRKKRSANKSKTMSNSVDKDNVLVSTHAMSNDILDEKLSADQPNSQRKPLLVDSTDEPSHIDLPLTQESLANDILPLLTLEGDSTCTTVPANTAVNSNTLTPPLFAYTPLSVLQEPEPASLPRDLDDFHDNLCLPSRIYLVSQEGEIYCDDGAISQPSSPYHPPLSSSPFVDDFPGWNDGYSSSNISDRHLPEEEIQEDRWLNLIEMADPEPFTSTSANLGLSFYNSTTTFQYPLDHRLDEGRFIKRISGIDYLSRIGCHDGDAAQYEEPEDIRHFIKSTWDAESGLDVQNTSSFLKMELDVDVEVDDTGCRRSIWDMLKVEHVEHVVEGHTEGNACDSGELGGDREGGSFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KH08</accession>
    <name>W4KH08_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_101210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW84999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541896.1">
        <property type="nucleotide sequence ID" value="XM_009543601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KH08"/>
    <dbReference type="GeneID" id="20665746"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_101210"/>
    <dbReference type="eggNOG" id="ENOG502SZT3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_731798_0_0_1"/>
    <dbReference type="InParanoid" id="W4KH08"/>
    <dbReference type="OrthoDB" id="3228154at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW84999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="391" mass="42199" checksum="B75EB625208D8C85" modified="2014-03-19" version="1">MFHLQSLIRADYRKSLFTSRSALVENTNASLNASDLPSSLSSWNSKASPTVALSSACARPHCEPSTNIIPFPTNSHPDPSISSALPLDYESLSRPKRALPLDAPRQRCQTPPSHSLAPRRKALPLPGVIRQRSASQSSATGVVRSQKRLKRGKRVTAELMFTAAVHRSIVCRMKRARELNGSCEQNTDVEMKSMGAKDDGSLILNAQEELLVARLWQRLVDQGCSPVLLDDRTVGVPDRPRTSNSVGVVEDLSMDITPSHRMESLLPTGISALIHSPAVLPPPPTISPPPPPEASVAISSPFSIVSLPPPVPRRHAPIPSSARSISVAPDALTVYTMPQLVATLTIRYRDRKAVKARASLPQTKKLSRTKSALATGRVVVAEAAVGSRLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHJ4</accession>
    <name>W4KHJ4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Ribosomal RNA-processing protein 8</fullName>
            <ecNumber evidence="9">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_314579</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the methyltransferase superfamily. RRP8 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544208.1">
        <property type="nucleotide sequence ID" value="XM_009545913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHJ4"/>
    <dbReference type="FunCoup" id="W4KHJ4">
        <property type="interactions" value="408"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KHJ4"/>
    <dbReference type="GeneID" id="20670139"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_314579"/>
    <dbReference type="eggNOG" id="KOG3045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027694_2_2_1"/>
    <dbReference type="InParanoid" id="W4KHJ4"/>
    <dbReference type="OrthoDB" id="10258825at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016433">
        <property type="term" value="F:rRNA (adenine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2150:FF:000001">
        <property type="entry name" value="Ribosomal RNA-processing protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2150">
        <property type="entry name" value="Ribosomal RNA-processing protein 8, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007823">
        <property type="entry name" value="RRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042036">
        <property type="entry name" value="RRP8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05148">
        <property type="entry name" value="Methyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW84551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="392" mass="43507" checksum="1FB63EA747510DE0" modified="2014-03-19" version="1">MALFEVPGWTMPSAPMTNISQRSGKRKRPSDTSKVQSAEVNLEKLMKKLKKNGEPTSLQAKGKTTRKIPDASIARSKEKSSKPKGDGSRTAVGGKVKQNISGPTEKHPISTEDTTGSLPSSKRKVKKDAQAQSKNLPKKSSSQIAGLTTLQNNMKQSLDGARFRWINEVLYKSDSAHAHDMMREDRNVFDEYHKGFRHQVESWPSNPVSHYISILSSYPPKTVIADLGCGDAALARSLIPKGFTVLSFDLVSDGAFVTEADIFGRLPLPGSETDEEEVPRSTEGHGQVTDVVICALSLMGTNWPNCIREAWRVLRSGGELKIAEVASRFTDISEFTSLVSSFGFKLKSSDDRNTHFTLFEFKKISRNSRSDPEWEELLSRGNVLKPCEYKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHT8</accession>
    <name>W4KHT8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">GTPase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_154562</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542266.1">
        <property type="nucleotide sequence ID" value="XM_009543971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHT8"/>
    <dbReference type="FunCoup" id="W4KHT8">
        <property type="interactions" value="461"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KHT8"/>
    <dbReference type="GeneID" id="20667503"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_154562"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_21_3_1"/>
    <dbReference type="InParanoid" id="W4KHT8"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01874">
        <property type="entry name" value="Cdc42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000236">
        <property type="entry name" value="Cell division control protein 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037874">
        <property type="entry name" value="Cdc42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW85402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="191" mass="21343" checksum="96050277C03DA24E" modified="2014-03-19" version="1">MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGDDPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVTSPASFENVKEKWFPEVHHHCPGVPCLIVGTQIDLRDDPQVMEKLQRQKQRPVTSEQGERLARELGAVKYVECSALTQKGLKNVFDEAIVAALEPPVVKKRNKCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIG3</accession>
    <name>W4KIG3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SDA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_154456</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 60S pre-ribosomal subunits export to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SDA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542478.1">
        <property type="nucleotide sequence ID" value="XM_009544183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIG3"/>
    <dbReference type="FunCoup" id="W4KIG3">
        <property type="interactions" value="564"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KIG3"/>
    <dbReference type="GeneID" id="20667496"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_154456"/>
    <dbReference type="eggNOG" id="KOG2229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009161_2_1_1"/>
    <dbReference type="InParanoid" id="W4KIG3"/>
    <dbReference type="OrthoDB" id="2196187at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027312">
        <property type="entry name" value="Sda1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048292">
        <property type="entry name" value="SDA1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007949">
        <property type="entry name" value="SDA1_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012977">
        <property type="entry name" value="SDA1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730">
        <property type="entry name" value="HSDA/SDA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730:SF0">
        <property type="entry name" value="PROTEIN SDA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21638">
        <property type="entry name" value="SDA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05285">
        <property type="entry name" value="SDA1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08158">
        <property type="entry name" value="SDA1_HEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SDA1 N-terminal" evidence="9">
        <location>
            <begin position="60"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 N-terminal" evidence="9">
        <location>
            <begin position="195"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 middle" evidence="8">
        <location>
            <begin position="531"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 C-terminal" evidence="10">
        <location>
            <begin position="701"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="520"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="677"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="526"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="677"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="730"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW85642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="750" mass="84018" checksum="365746054CBA7167" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIK1</accession>
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        <submittedName>
            <fullName evidence="11">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_60846</name>
    </gene>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
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    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="ETW85534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009543560.1"/>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_60846"/>
    <dbReference type="eggNOG" id="KOG0255">
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    <dbReference type="HOGENOM" id="CLU_008455_11_6_1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="69"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW85534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="547" mass="59636" checksum="9968B70B7F0B9B3C" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJ53</accession>
    <name>W4KJ53_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor spt8 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_310339</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009544393.1"/>
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    <dbReference type="eggNOG" id="ENOG502QS8F">
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    <dbReference type="OrthoDB" id="10260946at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="7"/>
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    </dbReference>
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    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="5">
        <location>
            <begin position="141"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="268"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="5">
        <location>
            <begin position="381"/>
            <end position="618"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="352"/>
            <end position="426"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
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            <end position="65"/>
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    </feature>
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        <location>
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            <end position="88"/>
        </location>
    </feature>
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        <location>
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            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW85878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="622" mass="66724" checksum="EDD2B2FF421D8BF5" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJC2</accession>
    <name>W4KJC2_HETIT</name>
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        <recommendedName>
            <fullName evidence="2">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
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                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF286">
        <property type="entry name" value="5-PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW85958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="429" mass="47271" checksum="34311D105E8F9E74" modified="2014-03-19" version="1">MLPDSASRIDRVLVQLASYNTALQGVQGVPQDLVDWLSPTLEVSNFLARDPRGPDIVAVGFQELLPLHLGLSGFSRSVIENRNALILSQIEAHAPDKGRYSLVAKVVNVGVALLVYAKDTGIARRVTDVQTSWIGCGPAYMGNKGAVGVRFRVQNVDAGVGEVYTFVCAHLTAHEPKLAQRIADYHHIVRSLLFAPLPGTSTTSPSTIYSTSHLFLLGDLNFRLALPSSHALAGPANRLNLESALSTLEGREELKEFDQLLVEHRNNTVLQGMREGEFWQFKCSYKYDIGKVDHYSTKRTPSWTDRILYTTYTDSPDTPDKTDITNMLYTAIPSYTTSDHKPIVSLLLLPPSSPSISSPLETIPLLQHRPDFSPDRYATLKRYTGRTLDRIIGVAWLFLVVIGAGNAVIGVGNCLLGIGAWTWWKEKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJR4</accession>
    <name>W4KJR4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Snf7-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_122216</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Bondarzewiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
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                <person name="Bouzid O."/>
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                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009544578.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="W4KJR4">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KJR4"/>
    <dbReference type="GeneID" id="20666772"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_122216"/>
    <dbReference type="eggNOG" id="KOG2911">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021165_1_0_1"/>
    <dbReference type="InParanoid" id="W4KJR4"/>
    <dbReference type="OrthoDB" id="10250120at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF96">
        <property type="entry name" value="BCDNA.GH08385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25880">
        <property type="entry name" value="WHD_CHMP7_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="434"/>
            <end position="465"/>
        </location>
    </feature>
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            <begin position="264"/>
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        </location>
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            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW86097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="51582" checksum="0750C00848076510" modified="2014-03-19" version="1">MPPTSSISSKQFLSLPNFTGTSPSRLQSLYSDISRQKHSNPTSYQSNVSWWRATLEAIVAKGWQPNSSDKLVLHVDQSLPDYLRYEGTGKPLCLGTVIAELSSSLLAIPLSQFLGATQSVYDKGWLPLRIASYVIGKPLWWALQQANIVGTDEGGHESDAERWRKVKGEYVVLALVERAAESVLERQRQIAGSLADTLFNFDSFRVEFSGNALEGVTLSDMDIKVLVKFLERDKSAVVVDKEVIKFIDASTTEPLEITAVDRGILELKTVVANLDKQIERIQRKMDECTEKAIVALRQKRKELALSYIRSRKLSEDLLRQRLGSIETLQSTLIRVEAAAGDIQIMKSYESSTTTLRTLLAHPSLQRDTIDQTLDALAAANADAKHVDDAIRMGGDIAMAEAGIEIDDAELEAELAKLVEEGEREQLEKADMDRLARQHMQKDAVPEQEPVVSKDSYGAVPVLENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJX7</accession>
    <name>W4KJX7_HETIT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_407882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJX7"/>
    <dbReference type="GeneID" id="20672636"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_407882"/>
    <dbReference type="HOGENOM" id="CLU_2812674_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJX7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="67" mass="7482" checksum="07463CA7F7930CFB" modified="2014-03-19" version="1">MSRGINVSSSGVLDNAVDLRRAALAKVIEFEVPKALPRAIRPDRKRCLSQWYCDSDVTDEHAKTHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KK24</accession>
    <name>W4KK24_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_122247</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542836.1">
        <property type="nucleotide sequence ID" value="XM_009544541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KK24"/>
    <dbReference type="FunCoup" id="W4KK24">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KK24"/>
    <dbReference type="GeneID" id="20666774"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_122247"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_22_0_1"/>
    <dbReference type="InParanoid" id="W4KK24"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="46"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="578"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="593"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="619"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW86054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="629" mass="67159" checksum="7823ED6DC8EBDBC0" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKA8</accession>
    <name>W4KKA8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Quinone oxidoreductase 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">qor6</name>
        <name evidence="2" type="ORF">HETIRDRAFT_43155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541769.1">
        <property type="nucleotide sequence ID" value="XM_009543474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKA8"/>
    <dbReference type="FunCoup" id="W4KKA8">
        <property type="interactions" value="309"/>
    </dbReference>
    <dbReference type="GeneID" id="20674544"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_43155"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_1"/>
    <dbReference type="InParanoid" id="W4KKA8"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08267">
        <property type="entry name" value="MDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052733">
        <property type="entry name" value="Chloroplast_QOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44013">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C16A3.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44013:SF1">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C16A3.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="20"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="353" mass="37904" checksum="06B8ED9E8F75FB12" modified="2014-03-19" version="1">MSLPTQIPQTQKAWRVVAQGPPSKALRLDKELPVPTQLDKGNVLVKVQAAALNPVGYKLMKLLPNFVSGRPFIAEQDFSGIVVDANGTNFANGDEVFGWIPVDLNRKTKYGALSEYTVAPAGNLAIRPPNISATQASGISLAGMTAYQALFQSAQLEEGQSLFVNGGSTTVGSYAIQFAKATGVKVVASASEKNKDFVLGLGADEFVDYTKQDLATFFSQNPPSPKFNVILDAVGLADGSLYAKSEKYLAPGGVFVSVGPTPTGWSSTLQLLKLITDLVRPTWLGGVRRKWTMVMVSHKDEDLEAMRKLIADGKVKPVVDSVHAFDDAINAYDRITSMRATGKVVVKVDPRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKB7</accession>
    <name>W4KKB7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_100305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542937.1">
        <property type="nucleotide sequence ID" value="XM_009544642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKB7"/>
    <dbReference type="GeneID" id="20665680"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_100305"/>
    <dbReference type="HOGENOM" id="CLU_2979353_0_0_1"/>
    <dbReference type="InParanoid" id="W4KKB7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="58" mass="6332" checksum="C69045E3F9EE3D30" modified="2014-03-19" version="1">MGESTGLRDPKAEKFGAPVRTCIDRDKYLKLDAGLAVMRSGLDVESLNAQALKLKLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKP6</accession>
    <name>W4KKP6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_414631</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542477.1">
        <property type="nucleotide sequence ID" value="XM_009544182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKP6"/>
    <dbReference type="FunCoup" id="W4KKP6">
        <property type="interactions" value="473"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KKP6"/>
    <dbReference type="GeneID" id="20673192"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_414631"/>
    <dbReference type="eggNOG" id="KOG3041">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062658_0_0_1"/>
    <dbReference type="InParanoid" id="W4KKP6"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18888">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF1">
        <property type="entry name" value="ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="49"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW85641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="208" mass="23087" checksum="E9412A3C45010F07" modified="2014-03-19" version="1">MAQDPVVLSKEDLDTRNAKWVSLKKIKWKDSEGKERAWEVAERRTRGSTDVDAVAILALIRSKTRAFPVSTVIIEQYRPPIGKFIVELPAGLIDNGETAEQAAIRELKEETGYVADSVVDMTAVLATDPGMTTANMKLVTLNVVFLGKLETPDQKLDDGEAIVRRVVELKGLYKELKGSFRLGFVVDARLFHFAAGFELAHQVNDETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKT9</accession>
    <name>W4KKT9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_306129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540488.1">
        <property type="nucleotide sequence ID" value="XM_009542193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKT9"/>
    <dbReference type="GeneID" id="20669382"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_306129"/>
    <dbReference type="HOGENOM" id="CLU_1204912_0_0_1"/>
    <dbReference type="InParanoid" id="W4KKT9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="230" mass="24929" checksum="6CAA5039587EC8C3" modified="2014-03-19" version="1">MGITGSLPLRWSNPAKSGVKMGSTDSKGMSLSKLTFMFLIYFLCPWDVDNCSKHPQLVPTIPIPNHSHVSSSVTTTTLIGSSQLKSLGCRTDSSCIINVDHHSEGSKHVNHIRCSIDSGVTHLGLKCSRDSNTSNVSIPVKRCRGPESGPKFTQSSNVQTLVCNLIVFVTNCSFGNLKSRRFFPRSLVEDVWNGGLDCTCSTGARGVLRYSNEGCSRKTTVDEVDSVKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLR6</accession>
    <name>W4KLR6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_308468</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540661.1">
        <property type="nucleotide sequence ID" value="XM_009542366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLR6"/>
    <dbReference type="STRING" id="747525.W4KLR6"/>
    <dbReference type="GeneID" id="20669590"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_308468"/>
    <dbReference type="eggNOG" id="ENOG502SIP3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007340_4_0_1"/>
    <dbReference type="InParanoid" id="W4KLR6"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="617"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="625"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW86659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="766" mass="85445" checksum="13E804D79E627C80" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMN2</accession>
    <name>W4KMN2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_242938</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homotrimer. Homotrimerization increases the affinity of HSF1 to DNA. Interacts with transcriptional coregulator SSA1 on chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543041.1">
        <property type="nucleotide sequence ID" value="XM_009544746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMN2"/>
    <dbReference type="STRING" id="747525.W4KMN2"/>
    <dbReference type="GeneID" id="20668957"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_242938"/>
    <dbReference type="eggNOG" id="KOG0627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030308_8_1_1"/>
    <dbReference type="InParanoid" id="W4KMN2"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="9">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW86286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="183" mass="21174" checksum="B6E360BAD526CBEE" modified="2014-03-19" version="1" fragment="single">VPQFLQKLYEIVNDPSNNDMIRWSDNGDSFVVLDHERLSREVLGRWFKHQKFASFVRQLNMYGFHKIPHLQQGVLKSDSDTEIWNFEHPHFHRGQPDLLCFIQRKKQAAQGGAPEDAILLDMNSIVSGIAAVKRHQQAISAELNELKTSNQHLWQEALAARERHKAHQDTINRILKFLASVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KN37</accession>
    <name>W4KN37_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_307532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540482.1">
        <property type="nucleotide sequence ID" value="XM_009542187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KN37"/>
    <dbReference type="GeneID" id="20669498"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_307532"/>
    <dbReference type="HOGENOM" id="CLU_1964769_0_0_1"/>
    <dbReference type="InParanoid" id="W4KN37"/>
    <dbReference type="OrthoDB" id="2753930at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="128" mass="14121" checksum="0547E4F05EA1FCFD" modified="2014-03-19" version="1" fragment="single">QIMYGALLRYGEVLYFFQHKANNTMHTLTMVSLYGLENEFLLAESSGTVWVCQAQGNNTLVVINVKTILTCVAMVLYIFLIPDTDLLQLYLAMDKLGADIGNMGGASENDNNVSDDDNDHDEVLPVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNH8</accession>
    <name>W4KNH8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_308415</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6 8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6 8">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541291.1">
        <property type="nucleotide sequence ID" value="XM_009542996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNH8"/>
    <dbReference type="STRING" id="747525.W4KNH8"/>
    <dbReference type="GeneID" id="20669583"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_308415"/>
    <dbReference type="eggNOG" id="KOG1294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027539_1_1_1"/>
    <dbReference type="InParanoid" id="W4KNH8"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF6">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 6 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="10">
        <location>
            <begin position="55"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="7">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW87383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="321" mass="36256" checksum="B664F1846FFFFD86" modified="2014-03-19" version="1">MSLKRKAGSNLTANSSQKKPKNDFFTPKSSTAVGSSSTPQFAFDRREAGTVRLSTWNVNGIKSVNGKTLRKYLEAEDPDILLTETKVAQGKADIMSLKTRFKQCVSSIGSWWLTIAGTAVLSKHKPFNVVVGLPTWPDSIEDTQGRYVQMEFENLYLVGTYVPNSGENFKSIDIKQKWNAAFSEHLHGLNAIKPVIWAGDFNCIPTKKDLDNKAQAFWDKMSGLSATERREFEGIINPGEQDSKRGKFVDIWRHLHPDAEEFTCVRRLCQTVTKFGAWRLDSFILSERILGNAKKCEIRHELKDLKLSDHWPVTLDILGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNK9</accession>
    <name>W4KNK9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dilute domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_469386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541303.1">
        <property type="nucleotide sequence ID" value="XM_009543008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNK9"/>
    <dbReference type="GeneID" id="20677290"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_469386"/>
    <dbReference type="eggNOG" id="ENOG502QRMC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006124_0_0_1"/>
    <dbReference type="InParanoid" id="W4KNK9"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15473">
        <property type="entry name" value="Myo5p-like_CBD_DIL_ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW87397.1"/>
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            <dbReference type="Proteomes" id="UP000030671"/>
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</entry>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
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                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
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                <person name="Rouze P."/>
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                <person name="Solheim H."/>
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                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
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            <end position="50"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
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            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
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                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
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                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
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                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Yakovlev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">TC 32-1</strain>
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    </dbReference>
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    <dbReference type="STRING" id="747525.W4KNR5"/>
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    <dbReference type="eggNOG" id="ENOG502SBNZ">
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    </dbReference>
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    <dbReference type="OrthoDB" id="250329at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF05920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW87030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="634" mass="69217" checksum="7975373CE3D077BC" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPC9</accession>
    <name>W4KPC9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RecA family profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_447533</name>
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        <lineage>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
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                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
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                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the RecA family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540859.1">
        <property type="nucleotide sequence ID" value="XM_009542564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPC9"/>
    <dbReference type="FunCoup" id="W4KPC9">
        <property type="interactions" value="439"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KPC9"/>
    <dbReference type="GeneID" id="20675785"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_447533"/>
    <dbReference type="eggNOG" id="KOG1433">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041732_0_2_1"/>
    <dbReference type="InParanoid" id="W4KPC9"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000008">
        <property type="entry name" value="DNA repair protein RAD51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF39">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="4">
        <location>
            <begin position="98"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="5">
        <location>
            <begin position="203"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW86891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="28826" checksum="240CEF22B02CED1A" modified="2014-03-19" version="1">MASQESEVPQEEGEEELQISGPLLINKLQEAGIHAQDIKKLADAGFHTVESVAYTSKKNLISIKGISEQKAEKFLAEAQKIVPLGFQSATEVHARRSELVHITTGSKNLDTLLGGGIETGSITEFFGEFRTGKSQICHTIAVTCQLPVDMGGGEGKCLYIDTEGTFRPVRLLAVAERYGLNGEEFGIAVVFSNQVMSTPDAAAGPYASNEKKPIGGNILAHASTTRLQLKKGRANTRICKIYDSPCLPESETSFAILQSGIGDPEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPJ7</accession>
    <name>W4KPJ7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_59331</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540402.1">
        <property type="nucleotide sequence ID" value="XM_009542107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPJ7"/>
    <dbReference type="FunCoup" id="W4KPJ7">
        <property type="interactions" value="116"/>
    </dbReference>
    <dbReference type="GeneID" id="20678468"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_59331"/>
    <dbReference type="eggNOG" id="KOG1483">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_4_3_1"/>
    <dbReference type="InParanoid" id="W4KPJ7"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="12"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="306"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="140"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW87290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="426" mass="45991" checksum="724825C843171D96" modified="2014-03-19" version="1">MGLSRTSRISLLLAIDVCFFFVELIVGYAVGSLALVADSFHMLNDVVSLIIALYAIKLTAQSTPNTQYSYGWHRAEILAALVNGVFLLALCFTITLEALQRFFSTPEISNPRLVVIVGSLGLASNIVGLFLFHEHGHSHSHDHSHSSSNTPSKTPTIHRSSISRPRSSFDARPVDGQAAVDDAADADAPPPASDGALVNERTPLLHTASHHSAEGDVTPPSEEWSSHGHAHSHGGSMNMKALLLHVLGDALGNVGVIATGLIIWLSSWSFKFYFDPIISLVITVIIFHSALPLVRSTSFILLQGVPSEVSLEDVRTAILNVDGVLSVHELHIWQLSESKIIASVHVTSSRNHDFMPVAAKIRQVLHQHGIHSSTIQPEYHPTREAIPDEFLKTSEDTSCLISCPPDQACGADHACCPPVNSLTDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KRV3</accession>
    <name>W4KRV3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_424455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541640.1">
        <property type="nucleotide sequence ID" value="XM_009543345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KRV3"/>
    <dbReference type="GeneID" id="20673966"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_424455"/>
    <dbReference type="HOGENOM" id="CLU_040945_0_0_1"/>
    <dbReference type="InParanoid" id="W4KRV3"/>
    <dbReference type="OrthoDB" id="3049938at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW87776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="27590" checksum="7FAA5641B14CF7AC" modified="2014-03-19" version="1">MYILANPTKYDMDMNKTLLVLSYIREGTAALFTQKYYFDRELQEYKATETKVAWGMFKAFLKELATAFKDKGLEQKARQKMFTMRMGKRTADDFVTDYLITAGESGFNLESTIDYFHRAIHLEILKQIYRLLEMPTTMDDWNNPFRYNSSNAPSSMNNSVIPMAIDMVRTALTNEEQNRLRMEGYMKGQLDMFNRVMERWGTTRLRPVEGWQQEEEAMAECSWQELRAVMREAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KRV8</accession>
    <name>W4KRV8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_307291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541644.1">
        <property type="nucleotide sequence ID" value="XM_009543349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KRV8"/>
    <dbReference type="GeneID" id="20669478"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_307291"/>
    <dbReference type="HOGENOM" id="CLU_2644670_0_0_1"/>
    <dbReference type="InParanoid" id="W4KRV8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="77" mass="8828" checksum="977ABB3DD2317577" modified="2014-03-19" version="1" fragment="single">SPFNATLSLYYDTLLIELSFQCPTYCLAFVADIPIAILYAGIFWYKALMVLFSLHWAFVFPSLPYYLAIFTNSLNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4KRW3</accession>
    <name>W4KRW3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_414086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541648.1">
        <property type="nucleotide sequence ID" value="XM_009543353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KRW3"/>
    <dbReference type="STRING" id="747525.W4KRW3"/>
    <dbReference type="GeneID" id="20673150"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_414086"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2027029_0_0_1"/>
    <dbReference type="InParanoid" id="W4KRW3"/>
    <dbReference type="OrthoDB" id="3250101at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW87786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="14451" checksum="0E7E6BC15F80C8E5" modified="2014-03-19" version="1">MEYPLRPKLYSLSPMEQEELKKFIDKSLKKGFIRESKSHMTSPFFFIKKKNRKLWPLLDLSIDVEYFSLVNINTGYNNILINEKDIHKAAFATNLEMYEPLVMYFGLTNSSATFQTMMNLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMZ8</accession>
    <name>W4JMZ8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_332267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0696 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553371.1">
        <property type="nucleotide sequence ID" value="XM_009555076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JMZ8"/>
    <dbReference type="GeneID" id="20671718"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_332267"/>
    <dbReference type="eggNOG" id="ENOG502S86E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062058_0_0_1"/>
    <dbReference type="InParanoid" id="W4JMZ8"/>
    <dbReference type="OrthoDB" id="10067381at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015034">
        <property type="entry name" value="Bles03"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977:SF1">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08939">
        <property type="entry name" value="Bles03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
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    </evidence>
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            <taxon>Heterobasidion</taxon>
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        </lineage>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Duplessis S."/>
                <person name="Durling M."/>
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                <person name="Fossdal C.G."/>
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                <person name="James T.Y."/>
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                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Yakovlev I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="550" mass="59158" checksum="B54C472913462105" modified="2014-03-19" version="1"> </sequence>
</entry>
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                <person name="Bouzid O."/>
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                <person name="Coutinho P.M."/>
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                <person name="van Diepen L.T."/>
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                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Yakovlev I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="544" mass="62395" checksum="A48A7D7EC517DBBC" modified="2014-03-19" version="1"> </sequence>
</entry>
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                <person name="van Diepen L.T."/>
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                <person name="Gonthier P."/>
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                <person name="Fossdal C.G."/>
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                <person name="Hietala A."/>
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                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Yakovlev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
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            <end position="29"/>
        </location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPV5</accession>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
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                <person name="James T.Y."/>
                <person name="Karlsson M."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="20671732"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_332471"/>
    <dbReference type="HOGENOM" id="CLU_1563074_0_0_1"/>
    <dbReference type="InParanoid" id="W4JPV5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW74906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="171" mass="18276" checksum="622F2A9ED3E99522" modified="2014-03-19" version="1">MQNRTRPSFFSNGSKREVNANAGGRQASLSDAISRYPLAAASSSIVQQPEYHKSALAAAARIMTQLGVFRVLLHIRPQNVMAAPQSPAHDDRLSPSEVGNASGSPSPSFRRTKHTKLPFPTVSAFSSYPALIPGRAAVPNGLNGCRDYIGCVVGRPHEPPALSLCGHRLIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQA9</accession>
    <name>W4JQA9_HETIT</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_422410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552005.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQA9"/>
    <dbReference type="STRING" id="747525.W4JQA9"/>
    <dbReference type="GeneID" id="20673810"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_422410"/>
    <dbReference type="eggNOG" id="ENOG502S5FR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024881_0_0_1"/>
    <dbReference type="InParanoid" id="W4JQA9"/>
    <dbReference type="OrthoDB" id="78858at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019152">
        <property type="entry name" value="DUF2046"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15276:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15276">
        <property type="entry name" value="H4 D10S170 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09755">
        <property type="entry name" value="DUF2046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW75747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="403" mass="44209" checksum="8FC56F499F0C7CCA" modified="2014-03-19" version="1">MSLSPPIRRLSATSTSSKREEDLINAYEAEEERIINVLSRKLEKLQEEKIELENVLEAESESHVNRLSRELFALRLAQQSSQMQSQNHLSNGNGIGEPSIEHGRPARSMPSNPLAPSSDIMLEALLRENELLRNRMVDMEREYIRITRLNEIYREELIQHRRRLGLSVDNLIGLSSSHELYSQPTHRRSMSNTSSPAASAPIPLTAHATHPSPNVPIPRPPSQIHRPIHTTSESTTPLSHSPSSASESPYLSPLISTNPASYISNTTGVTTPPSSTSPTAIANGASRTAPLSYPSVPPPSLSSSFGSPTAYYHGPRRDLSSSPVEGHTNHRSVPRRGNFERRVADSQSLRRSVSRGNSRRESVERGARIAETGQLVPRSRAGSVALGGPSEVVAPVDEHADRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQC4</accession>
    <name>W4JQC4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_106406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551999.1">
        <property type="nucleotide sequence ID" value="XM_009553704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQC4"/>
    <dbReference type="GeneID" id="20666161"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_106406"/>
    <dbReference type="HOGENOM" id="CLU_1012142_0_0_1"/>
    <dbReference type="InParanoid" id="W4JQC4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW75738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="275" mass="31491" checksum="4B05234A3A6BE30F" modified="2014-03-19" version="1">MPAKEWTTSAEKLWLQDRVRNEYLQLTDQARTEWCRKVVSDFIETFPKEKRELNGVLESDAEVDERWDMVSNRVKKWIKNHRKRLAYDLPSPGPHRQANGIRKAPRRTRAKCARDVILKCDGPSAAKFWELNKCHRERTITKNEKMAMWGTFITERLKRPEVMALCQAKAQEYNSRTVKTVSPAPHSLIRGDLSSQTDLVGIGTGVYSGDLSSPALPASSRDLRSPSPPVDLFGWPHNRGPALVDWEDDFMFSCSQVLGEIGFVSPPFEYELIMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQC7</accession>
    <name>W4JQC7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HETIRDRAFT_53911</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551864.1">
        <property type="nucleotide sequence ID" value="XM_009553569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQC7"/>
    <dbReference type="FunCoup" id="W4JQC7">
        <property type="interactions" value="240"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JQC7"/>
    <dbReference type="GeneID" id="20678280"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_53911"/>
    <dbReference type="eggNOG" id="KOG2662">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025144_1_2_1"/>
    <dbReference type="InParanoid" id="W4JQC7"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045016">
        <property type="term" value="P:mitochondrial magnesium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.330:FF:000002">
        <property type="entry name" value="Inner membrane magnesium transporter mrs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="391"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="274"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETW75767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="417" mass="46631" checksum="28FDE38B86AACFA2" modified="2014-03-19" version="1">MRNSSRKSHSRSSRSLHSVYISSRGARAMSWTSRFNIWPEESYTGPSDGREEAAKAAILEKAIKGRQQTDLMLRCTILDAVGNVKTISGQFKRSDLSSEHRLNPRDLRKIDSRIPNLVPTILVRREAILVNVLHIRALVKADAVILFDTYGSTDSRLHSVFLYHLEHNLKMKGAGLPYEFLALESIFLSVVSALEAEMVFIRNLLGGLLAELEDDIDHDKFKRLLHYSRRLTSFLNRAKLVQESIDEVLEQDEDLAAMYLSDKKKGLARTLNDHDELEVLLETFSKQVEEIVNEAENTQSNVQSTQEIVELILDSNRNALLALDLKVSIGTMGIGMGALIAGLFGMNLTSHIEATPYAFVAMSVLSTAVAVLVSWTGLRRLAKIQKVGLSASSGHKGHNRRHRPWLPLPLRSRRSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQM4</accession>
    <name>W4JQM4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">nrap1</name>
        <name evidence="13" type="ORF">HETIRDRAFT_482102</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the NRAP family.</text>
    </comment>
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        <property type="protein sequence ID" value="ETW75380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552802.1">
        <property type="nucleotide sequence ID" value="XM_009554507.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="W4JQM4">
        <property type="interactions" value="642"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JQM4"/>
    <dbReference type="GeneID" id="20678007"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_482102"/>
    <dbReference type="eggNOG" id="KOG2054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003502_1_1_1"/>
    <dbReference type="InParanoid" id="W4JQM4"/>
    <dbReference type="OrthoDB" id="10251401at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035082">
        <property type="entry name" value="Nrap_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035367">
        <property type="entry name" value="Nrap_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035368">
        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035371">
        <property type="entry name" value="Nrap_D6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03813">
        <property type="entry name" value="Nrap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17403">
        <property type="entry name" value="Nrap_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17407">
        <property type="entry name" value="Nrap_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nrap protein" evidence="7">
        <location>
            <begin position="250"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="8">
        <location>
            <begin position="407"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="9">
        <location>
            <begin position="573"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="10">
        <location>
            <begin position="742"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="11">
        <location>
            <begin position="972"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="12">
        <location>
            <begin position="1132"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="174"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW75380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1272" mass="140922" checksum="77A25C30CD3C79CD" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQU0</accession>
    <name>W4JQU0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fungal STAND N-terminal Goodbye domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_164411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552867.1">
        <property type="nucleotide sequence ID" value="XM_009554572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQU0"/>
    <dbReference type="GeneID" id="20667915"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_164411"/>
    <dbReference type="HOGENOM" id="CLU_1019631_0_0_1"/>
    <dbReference type="InParanoid" id="W4JQU0"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031350">
        <property type="entry name" value="Goodbye_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17109">
        <property type="entry name" value="Goodbye"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal STAND N-terminal Goodbye" evidence="1">
        <location>
            <begin position="10"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="273" mass="31290" checksum="D0169F216437F40D" modified="2014-03-19" version="1">MADSQYDEIWKSALKHYEQDTKTAIQTHISNTDTPNDLLQKIKDDFAQFRKKGKRLRDKIKAVLRLVGLFAEMTGEAVGTKYPLGKAIFAGIRVLLESSKSVSSNYESIIEMFEYFDDFPSRLEIHNKHKITDPVKKIIIEFLAQLLSVIGLTTKLIKEGRMKRYFKSLIREDDDVKDAMGKLDRLTKEEDRVVFSVTLSVVNTILASLEEQMRSGKEEIVSTRDVILKEIRELNGGVSHVLHPGLRANQFRRCFRPNPQGYDATRSCLFCVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQU9</accession>
    <name>W4JQU9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aryl-alcohol oxidase 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">aao9</name>
        <name evidence="11" type="ORF">HETIRDRAFT_67820</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552529.1">
        <property type="nucleotide sequence ID" value="XM_009554234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQU9"/>
    <dbReference type="GeneID" id="20678828"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_67820"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_3_1"/>
    <dbReference type="InParanoid" id="W4JQU9"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0274">FAD</keyword>
    <keyword evidence="3 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844023" evidence="8">
        <location>
            <begin position="21"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="9">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="532"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="576"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="122"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="531"/>
            <end position="532"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW75266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="601" mass="63522" checksum="AF8AB8310D7767D8" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSB1</accession>
    <name>W4JSB1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="7">PPIase</shortName>
            <ecNumber evidence="2 7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_411791</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 7"/>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551256.1">
        <property type="nucleotide sequence ID" value="XM_009552961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSB1"/>
    <dbReference type="FunCoup" id="W4JSB1">
        <property type="interactions" value="213"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JSB1"/>
    <dbReference type="GeneID" id="20672970"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_411791"/>
    <dbReference type="eggNOG" id="KOG0865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_4_3_1"/>
    <dbReference type="InParanoid" id="W4JSB1"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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            <begin position="23"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW76334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="180" mass="19417" checksum="9749FEF21C497ECB" modified="2014-03-19" version="1">MASFLRRFTTAASAAKTPMANVFFDIAIDSKPTGRVVFKLFDETVPKTARNFRELATGQHGFGYAGSTFHRIIPNFMLQGGDFTRHNGTGGKSIYGEKFADENFTLQHTKPGLLSMANAGANTNGSQFFITTVVTSWLDGRHVVFGEVVEGMDVVKKVEAVGTDSGRPKAQVTITSSGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSI5</accession>
    <name>W4JSI5_HETIT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_430478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSI5"/>
    <dbReference type="GeneID" id="20674448"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_430478"/>
    <dbReference type="HOGENOM" id="CLU_590593_0_0_1"/>
    <dbReference type="InParanoid" id="W4JSI5"/>
    <dbReference type="Proteomes" id="UP000030671">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="463"/>
        </location>
    </feature>
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            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW76075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="463" mass="50982" checksum="540B96361E310C96" modified="2014-03-19" version="1">MVNMLSVGELTQVLPNILWRVVVGWVGTNRVWCKSASSVLVYAVWYLPKAFRIPPLDPSSVGRRLGVGAEKMVWQHCTWIRAHGIWMWESVGNKQWHGKKCWRESVSAKDGGTYRGLCRAPWHGALSGDHNHLPIIDSPATKSLITILLLLCLLVQMPSILPILKAKLAEYMLSLPDGAAEYEDYELWGQGFAHCVALLDRLAHGKDIPELADFIAKAERGLNHMATDNWLVWRVRVLPQRVACFAVKQQKEAKEQALAEETERAAAASRVAAEDYQWRWDVVVGAMFDGSLDPEEDEHQLPELDAKTAVPPPLFFPSPSPDPAPSADAILVSTTVAMNCMSVDPTALIAPIESQGKRAAAVVVEFACQRTPFQGWVIVSLSPGMGCMLTVQSPVERNGAGKMMQDPPGLMPGDANYACQRWMPNKGKSKGKGKLKAKVAEKSGEPEPSCPTKKRKVKVLVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSS1</accession>
    <name>W4JSS1_HETIT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_389663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSS1"/>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_389663"/>
    <dbReference type="HOGENOM" id="CLU_569924_0_0_1"/>
    <dbReference type="InParanoid" id="W4JSS1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="516" mass="56401" checksum="0DF247AC6B6B30D9" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTW6</accession>
    <name>W4JTW6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">HETIRDRAFT_460499</name>
    </gene>
    <organism evidence="4 5">
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        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009552269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTW6"/>
    <dbReference type="STRING" id="747525.W4JTW6"/>
    <dbReference type="GeneID" id="20677079"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_460499"/>
    <dbReference type="eggNOG" id="ENOG502SJR2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011606_0_0_1"/>
    <dbReference type="InParanoid" id="W4JTW6"/>
    <dbReference type="OrthoDB" id="312874at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="3">
        <location>
            <begin position="199"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="3">
        <location>
            <begin position="679"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="454"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="890"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="156"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW77007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="911" mass="103857" checksum="599F40BE96AF3AC8" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTY3</accession>
    <name>W4JTY3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polyketide synthase-like phosphopantetheine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_460739</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551243.1">
        <property type="nucleotide sequence ID" value="XM_009552948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTY3"/>
    <dbReference type="STRING" id="747525.W4JTY3"/>
    <dbReference type="GeneID" id="20677106"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_460739"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002220_1_0_1"/>
    <dbReference type="InParanoid" id="W4JTY3"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
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        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="675"/>
            <end position="750"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW76321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1173" mass="126227" checksum="2E9E8D5BD669D88E" modified="2014-03-19" version="1"> </sequence>
</entry>
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            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_429511"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="32"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="595" mass="65497" checksum="A0C4E9164DFD41BA" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4JV67</accession>
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        <recommendedName>
            <fullName evidence="3">Phosphatase activator</fullName>
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            <taxon>Bondarzewiaceae</taxon>
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            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384:SF16">
        <property type="entry name" value="GROWTH REGULATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="36040" checksum="B1F591842EB3FCC8" modified="2014-03-19" version="1">MAATMSSSPITQVQQVPTQAALQPPLLTRLSLDLRGKRFSVDRETIMNLPESVLLCLFPNGLVLSRQSIALSDGGENSEEEELYGVDFDPDCFSYVLQFFRNASDTFYGTETTPGLFAAQQPYIENAPSPEFAPAQNPLLTKQAIIVLREELEYFSIPPKNSGAATDSNGIANEGLLELKRNCGEYLLDKRNIFTALQRNVNKENNIAEQHLIDMLCMSGFDRDDEWGYRAVEPSRCCISSIALVLLKTGIVHSTSPAGERQVTIDYNQMSTAQKLLLFWRKPARKCWWDGIEIDLTPNGEQPRSVKLWARRVWTLELSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVE4</accession>
    <name>W4JVE4_HETIT</name>
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        <recommendedName>
            <fullName evidence="1">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_247617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550603.1">
        <property type="nucleotide sequence ID" value="XM_009552308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JVE4"/>
    <dbReference type="GeneID" id="20669185"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_247617"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_6_4_1"/>
    <dbReference type="InParanoid" id="W4JVE4"/>
    <dbReference type="OrthoDB" id="2630497at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46148">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46148:SF52">
        <property type="entry name" value="OS04G0603800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="1">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="110" mass="13001" checksum="98D8249F38BCA5D0" modified="2014-03-19" version="1" fragment="single">GTHIRTTHPKFKLAPRRYGPFKILTKVGTLAYRLQIPQHWRIHPVFHATTLTKYRETEAHGENFARPLPEVLNDEEHYEVEMIVDSKKQGRGTKYLVKWMGYPEADNTWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVH1</accession>
    <name>W4JVH1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_430138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551723.1">
        <property type="nucleotide sequence ID" value="XM_009553428.1"/>
    </dbReference>
    <dbReference type="GeneID" id="20674418"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_430138"/>
    <dbReference type="eggNOG" id="ENOG502R183">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_254108_0_0_1"/>
    <dbReference type="InParanoid" id="W4JVH1"/>
    <dbReference type="OrthoDB" id="3235325at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1226"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1379"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1233"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1245"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1265"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1384"/>
            <end position="1394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1404" mass="154014" checksum="3B578F713191DE20" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVW4</accession>
    <name>W4JVW4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_52446</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="ETW77215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550499.1">
        <property type="nucleotide sequence ID" value="XM_009552204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JVW4"/>
    <dbReference type="GeneID" id="20678215"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_52446"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_8_5_1"/>
    <dbReference type="InParanoid" id="W4JVW4"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF5">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
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                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550881.1">
        <property type="nucleotide sequence ID" value="XM_009552586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWA7"/>
    <dbReference type="GeneID" id="20671283"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_326941"/>
    <dbReference type="eggNOG" id="ENOG502S3G3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_676251_0_0_1"/>
    <dbReference type="InParanoid" id="W4JWA7"/>
    <dbReference type="OrthoDB" id="8955945at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="275"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW77365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="407" mass="45491" checksum="076DEF4607EBCC7C" modified="2014-03-19" version="1">MSGQASTSTNTPSATVQPGRGKVKLPDNYTGDRIESQKFMLQCLLLFAAESDRYKTDQDKISLVLSCMRYGTAGAWAENFLLKSVGADPPTDLGTWKDFLAKFKLQFRETGKTDKARSALMTFSQGRMTVDEYSNQFILIAADADISDKEQVPYFQRGLDPRVMDKIYDKEVQPKDTIQDWINTACEIDGRLRARTAQKAILANSTSFRSDYLNRFHNQISPRYNSTNAPRRMNNQVVDMDIDATRKRNALSQKRKYDGKPPSACYHCGKTGHWNTDCPSRRRGVQPTRGNSKRRMGTTGRRSRAVDLEGEDDAPAMGNQAGIYRGMETEDVPRNDQRVPQPGPSMERPHSTSSGRPQTNHGQRAMLPNGRRGDGSVSHSARIGAVLGELGEDEAREVILGHAERFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWJ5</accession>
    <name>W4JWJ5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine amidotransferase type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_446269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550788.1">
        <property type="nucleotide sequence ID" value="XM_009552493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWJ5"/>
    <dbReference type="STRING" id="747525.W4JWJ5"/>
    <dbReference type="GeneID" id="20675681"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_446269"/>
    <dbReference type="HOGENOM" id="CLU_1927900_0_0_1"/>
    <dbReference type="InParanoid" id="W4JWJ5"/>
    <dbReference type="OrthoDB" id="444432at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061672">
        <property type="term" value="C:glutathione hydrolase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052373">
        <property type="entry name" value="Gamma-glu_amide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187:SF1">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="131" mass="14626" checksum="A6EC0B37300A2742" modified="2014-03-19" version="1">MFNIDDFGIAWYTHTRAHFASKFMQGPRPAMYKTVAPALTDPTFIYICGNTASSCILAHIRAASAPPVVQTNDHPFIFGRHSFMHNGTVSNFRSIISRENVGMIRATRTWSTSRRVLHAPWGHGGHALDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWT6</accession>
    <name>W4JWT6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_479197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550027.1">
        <property type="nucleotide sequence ID" value="XM_009551732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWT6"/>
    <dbReference type="GeneID" id="20677860"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_479197"/>
    <dbReference type="HOGENOM" id="CLU_2184313_0_0_1"/>
    <dbReference type="InParanoid" id="W4JWT6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW78022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="11949" checksum="4FFC901430D20E23" modified="2014-03-19" version="1">MEGTGVGLGLGLGLSAFVPALFWCLRFLLALLCLPPSALFYFSLRFCPCTLLVCVCVVFRRFILFIYLVCCAMVRLSLFSIMLSSPPPLPSHPLKSSAAGRDTLLFSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWV1</accession>
    <name>W4JWV1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Metallo peptidase M35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_56025</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M35 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549657.1">
        <property type="nucleotide sequence ID" value="XM_009551362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWV1"/>
    <dbReference type="STRING" id="747525.W4JWV1"/>
    <dbReference type="GeneID" id="20678346"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_56025"/>
    <dbReference type="eggNOG" id="ENOG502SIJR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041257_0_0_1"/>
    <dbReference type="InParanoid" id="W4JWV1"/>
    <dbReference type="OrthoDB" id="412874at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11306">
        <property type="entry name" value="M35_peptidyl-Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050414">
        <property type="entry name" value="Fungal_M35_metalloproteases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029463">
        <property type="entry name" value="Lys_MEP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034115">
        <property type="entry name" value="M35_peptidyl-Lys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016:SF3">
        <property type="entry name" value="NEUTRAL PROTEASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14521">
        <property type="entry name" value="Aspzincin_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01351">
        <property type="entry name" value="Aspzincin_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845035" evidence="8">
        <location>
            <begin position="18"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Lysine-specific metallo-endopeptidase" evidence="9">
        <location>
            <begin position="212"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW77934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="350" mass="37288" checksum="CFC49A9133952684" modified="2014-03-19" version="1">MRAAIASLVLAALSASAAPSLTLSVSSPDDVVDVDNLKVKTILKNTGDESVKLLKTPESVISTYQTNSFAIASESGSVPSFTGVKVKYAASKVLTENKEESFVVLAPGQTFEVEHDLAGVYNFTKGGEGKYSFDANNRFFYVDAENKLKVVEAEAATTASMVSGKLAVVGSKPQRRSLQKRTVTFNGCTSSRQTSITTAAGHAVTYASDAASYLAGISAATTRYTTWFGAYTATRKNTVHSHYVNIGTDPTSSEYDCSTCTDSNVYAYVYPDTPAYVYLCGAFWDAPATGTDSKAGTIVHEQSHFTVNAGTEDYEYGQTACKSLATSDPAKAIENADTHEYFAENNPSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JX43</accession>
    <name>W4JX43_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_429216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550131.1">
        <property type="nucleotide sequence ID" value="XM_009551836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JX43"/>
    <dbReference type="GeneID" id="20674325"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_429216"/>
    <dbReference type="HOGENOM" id="CLU_446212_0_0_1"/>
    <dbReference type="InParanoid" id="W4JX43"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="612" mass="66465" checksum="97D564C1AC793531" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4JX61</accession>
    <name>W4JX61_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribokinase</fullName>
            <shortName evidence="9">RK</shortName>
            <ecNumber evidence="9">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_436313</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="9"/>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550969.1">
        <property type="nucleotide sequence ID" value="XM_009552674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JX61"/>
    <dbReference type="FunCoup" id="W4JX61">
        <property type="interactions" value="92"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JX61"/>
    <dbReference type="GeneID" id="20674883"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_436313"/>
    <dbReference type="eggNOG" id="KOG2855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_2_1_1"/>
    <dbReference type="InParanoid" id="W4JX61"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="10">
        <location>
            <begin position="45"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="34"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="62"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="263"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="298"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW77466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="366" mass="38645" checksum="D504B6F012184BFF" modified="2014-03-19" version="1">MSIAPVSHCLVRGSITHKYHKSTIHHISRSIASDVDEFFHVEDVVRPGETISSTQFERRAGGKGANQAAAVARAGGTVSLVGAVGEDGIWVMRDLEAMGVDVTNVSVVQEPTGRAVIQLTPTGENCIILHKGANYALQGPPSAVTLASTTHLLLQNEIPWPSTLAYLTAARAQGITTIFNPSPMPDDNQIRSFPWTRLSWLLVNEGEAESLLAAFPPDTPASDASFPVPAGWPSHASLVSAYTVVRKLAAHPFFSTTTNVICTLGAAGVLAFLPSLSQPIYIPAVTLHGDVRDTTGAGDCFTGYLVAGLMQLEAARADATALSDSDVINILTRSTQAAGMCVEKRGALESIPAAADVERRLKSIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXH6</accession>
    <name>W4JXH6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan 1,4-alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">1,4-alpha-D-glucan glucohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glucan 1,4-alpha-glucosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_157474</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal (1-&gt;4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 15 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550165.1">
        <property type="nucleotide sequence ID" value="XM_009551870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXH6"/>
    <dbReference type="FunCoup" id="W4JXH6">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JXH6"/>
    <dbReference type="GeneID" id="20667729"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_157474"/>
    <dbReference type="eggNOG" id="ENOG502QPM2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012173_2_1_1"/>
    <dbReference type="InParanoid" id="W4JXH6"/>
    <dbReference type="OrthoDB" id="6123450at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004339">
        <property type="term" value="F:glucan 1,4-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000165">
        <property type="entry name" value="Glucoamylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF12">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00736">
        <property type="entry name" value="GLHYDRLASE15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844144" description="glucan 1,4-alpha-glucosidase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="GH15-like" evidence="13">
        <location>
            <begin position="34"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW78169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="533" mass="58945" checksum="12594048E64FA658" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXU5</accession>
    <name>W4JXU5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_479554</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550371.1">
        <property type="nucleotide sequence ID" value="XM_009552076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXU5"/>
    <dbReference type="STRING" id="747525.W4JXU5"/>
    <dbReference type="GeneID" id="20677876"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_479554"/>
    <dbReference type="eggNOG" id="KOG0975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031922_0_1_1"/>
    <dbReference type="InParanoid" id="W4JXU5"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000002">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW78397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="406" mass="44280" checksum="1E0BC4BD95ACD1D9" modified="2014-03-19" version="1">MTFKSSELLNANGLPLPSGDVQVIKNGTLPTISELDPSKLSVTLTTIPKSLPHPDSLVFGQEMTDHMLLMSYDPLTGWSAPEIKPYGPLSIDPASSCFQYCPNVFEGMKAYIGPDGKPRLFRPDLNMARMKKSSDRVALPPFNTGALLTLIKKLILVDARWIPKAKGCSLYIRPTIIGTRPALGVSASTHAMLYVIMSPTGPYFKVPTGISLLAVGDHVRAWPGGTGGYKLGLNYAPGFHPQRLALQQGYQQVLWLLRETITEAGAMNIFVVLKRDDGDLDVFTPPLDGTILPGVTRASVISLLAAHPTETSLPELSNNTHLHTREQPITMPEIAAWSESGRLSEIFCVGTAVVVTAVSRIGWKGKDIVLPEYSKALGPVARALWERLVDIQEGRIEWQGWSTPCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXZ0</accession>
    <name>W4JXZ0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_325631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549972.1">
        <property type="nucleotide sequence ID" value="XM_009551677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXZ0"/>
    <dbReference type="STRING" id="747525.W4JXZ0"/>
    <dbReference type="GeneID" id="20671167"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_325631"/>
    <dbReference type="eggNOG" id="ENOG502SKW4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015091_3_2_1"/>
    <dbReference type="InParanoid" id="W4JXZ0"/>
    <dbReference type="OrthoDB" id="2674421at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="441" mass="49763" checksum="99CA5A74A1CA1D87" modified="2014-03-19" version="1">MISNARLVHSPPYSSEDWQTFTHPEGKPYSVLKLNKFHVVTEAAVSRPEVKVVVGLWVAVIEAWASELGLVMHDCDELWLELEPEKCRYFFVDHSNRTVFWLNAQTSSELGLPESHSANHIKHALEAEYWQFVEQFPMHFGGVTKEAFDELFNTFLHGQADQLTSGVSTFPYSAEECATFNNILRDSRDRIADGRVTCFVARLWVFLSTYRHQTHYGEEHCRLSRDQAILVAPEAKRSLILSALSLMLFNIPEGYRKRFQDLFVDDLAYLSVWRSFVNETSDEWKTLMQWAFGLLISNLLVLPSAALPAATVSSVVLSTASVVMTVIMSQHQQGLAKWDTGEAAVYLNEHKSSYGYQPIATVYALPKGLFIWSLIAFFAQGLYMLSRYAGFPVAVVSLAFIGVFVLAVWSTLLPGSFRSSFSWPSFGVRSRGPSLPENSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXZ2</accession>
    <name>W4JXZ2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="13">A-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_109007</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550375.1">
        <property type="nucleotide sequence ID" value="XM_009552080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXZ2"/>
    <dbReference type="STRING" id="747525.W4JXZ2"/>
    <dbReference type="GeneID" id="20666399"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_109007"/>
    <dbReference type="eggNOG" id="KOG0743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010189_3_2_1"/>
    <dbReference type="InParanoid" id="W4JXZ2"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="279"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW78403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="530" mass="57844" checksum="0A9AFC5D09F62552" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4JY15</accession>
    <name>W4JY15_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_421183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550438.1">
        <property type="nucleotide sequence ID" value="XM_009552143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JY15"/>
    <dbReference type="GeneID" id="20673705"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_421183"/>
    <dbReference type="eggNOG" id="ENOG502S2VI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037033_1_1_1"/>
    <dbReference type="InParanoid" id="W4JY15"/>
    <dbReference type="OrthoDB" id="2126185at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="350" mass="39684" checksum="099D2F3AA2911132" modified="2014-03-19" version="1">MDPQQTIGLLVLASYFLLIFVLLYIICASFLPLNVPRNGPNYRAYTFTVLTLSSFAHTWYYMFAFMGWSFSNYERLHSAEATQPMLERVGNWLANTGLFEEAWAVVCSTPRNWWWSEQLCLYTVGFWTVFLLSEGRRRKIKHIWAYMMLGQVVAISVAANLFYIALALYPDPKPEEKLTRRRNTVPMILWSSILLSLSTVYLVPTSIEQGYFLSNLLTMHVLLVIPLASPDALLSSAVLRMRARTLYGLIALASILPRIRTVSTAFASLPVEARHVSGAVSALWETLHSHPAQSSIGWDVVWTTASFFLWTFSPLQMIKYLIPCVLATSVPSAGFIAPFVMWRSSRAVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYA9</accession>
    <name>W4JYA9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase III subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_325316</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the RNA polymerase III (Pol III) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the eukaryotic RPC7 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550092.1">
        <property type="nucleotide sequence ID" value="XM_009551797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYA9"/>
    <dbReference type="STRING" id="747525.W4JYA9"/>
    <dbReference type="GeneID" id="20671136"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_325316"/>
    <dbReference type="eggNOG" id="ENOG502S7CU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090092_0_0_1"/>
    <dbReference type="InParanoid" id="W4JYA9"/>
    <dbReference type="OrthoDB" id="5377312at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024661">
        <property type="entry name" value="RNA_pol_III_Rpc31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11705">
        <property type="entry name" value="RNA_pol_3_Rpc31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000777">
        <property type="entry name" value="RNA_polIII_C31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW78090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="223" mass="24351" checksum="66B412BE42805DCC" modified="2014-03-19" version="1">MSRGGRGGRGGGRGGFGGGGRGGFGAGNLPPMGLTFADIQSMSREQSALYPAVEVLPVLTEYSDAEKAICERQIGFAIRLKTSRYYITEHTKSTELERYSDKYRPSTGTRPTLKRKELHQPFFPQDVFEGYFNPKKRRKGIEKKSSSKRVNLDDLGDDLDDPDKSDADRSDVGSQAAEEDYDVDEEYDNDYAENYFDNGEGDDMDDLGGGGGGDEGGGTSFSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYL8</accession>
    <name>W4JYL8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exonuclease 1</fullName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_55937</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">5'-&gt;3' double-stranded DNA exonuclease which may also possess a cryptic 3'-&gt;5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549656.1">
        <property type="nucleotide sequence ID" value="XM_009551361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYL8"/>
    <dbReference type="FunCoup" id="W4JYL8">
        <property type="interactions" value="142"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JYL8"/>
    <dbReference type="GeneID" id="20678345"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_55937"/>
    <dbReference type="eggNOG" id="KOG2519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021984_0_0_1"/>
    <dbReference type="InParanoid" id="W4JYL8"/>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF8">
        <property type="entry name" value="EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0228">DNA excision</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="7">
        <location>
            <begin position="356"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="200"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU910737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW77956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="552" mass="62031" checksum="20FCF6361ACA6097" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZ21</accession>
    <name>W4JZ21_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_386971</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549092.1">
        <property type="nucleotide sequence ID" value="XM_009550797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZ21"/>
    <dbReference type="FunCoup" id="W4JZ21">
        <property type="interactions" value="531"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JZ21"/>
    <dbReference type="GeneID" id="20672301"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_386971"/>
    <dbReference type="eggNOG" id="KOG0346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_17_1_1"/>
    <dbReference type="InParanoid" id="W4JZ21"/>
    <dbReference type="OrthoDB" id="1191041at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17961">
        <property type="entry name" value="DEADc_DDX56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF21">
        <property type="entry name" value="DEAD-BOX HELICASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
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</entry>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
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    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="162"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW78863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="314" mass="36391" checksum="7DF5EE861CD3C7CB" modified="2014-03-19" version="1">MANHTAIPHNLWTDYPFYYTPRPSVLPGVSDQALALAAPIIAYWVASLAFHALDISDWRWLDKYRLHDSTEVASRNLVTRTTVVWAVLLQQAIQTALGIFWMSDEGHEVNHAAEMQQVAALIARVSPMILGNSVAESWLKSEAHRLTYFSYWWFIPAIQLLWAMCIMDTWQYFLHRGMHVNKFLYKHLHSVHHRLYVPYAFGALYNHPLEGFLLDSVGAVLSETLSFMTVRQAAFFFVFSTFKTVDDHCGYSLPFDPLQWISGNTADYHDIHHQVIGIKSNFSQPFFVHWDMLLGTRMTRKEIEQRRAKTRKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4K059</accession>
    <name>W4K059_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_324374</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a component of both the DNA-binding general transcription initiation factor complex TFIID and the transcription coactivator SAGA complex. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TAF10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009551085.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="W4K059">
        <property type="interactions" value="243"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K059"/>
    <dbReference type="GeneID" id="20671047"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_324374"/>
    <dbReference type="eggNOG" id="KOG3423">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064104_4_0_1"/>
    <dbReference type="InParanoid" id="W4K059"/>
    <dbReference type="OrthoDB" id="154356at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017246">
        <property type="entry name" value="TFIID_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01443">
        <property type="entry name" value="TFIID30KDSUB"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW79114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="164" mass="18395" checksum="B03B1C364F25B0F6" modified="2014-03-19" version="1">MNSQQQSQPQFQPGQYAYPLVAGQAPQIQHQSSNAQQALPQSRFTAEQARKDRTLAEFMLMLDDYEPLIPDEVTDYYLHRSGFDCQDVRLKRLLALAAQKFVSDIAADAYQHARIRTNAAGGRTRANQPPGAAARKARTTLTMEDLSAALAEYGINSRKPEFYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0C2</accession>
    <name>W4K0C2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spt20-like SEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_460134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549493.1">
        <property type="nucleotide sequence ID" value="XM_009551198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0C2"/>
    <dbReference type="STRING" id="747525.W4K0C2"/>
    <dbReference type="GeneID" id="20677044"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_460134"/>
    <dbReference type="eggNOG" id="ENOG502QS30">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_335247_0_0_1"/>
    <dbReference type="InParanoid" id="W4K0C2"/>
    <dbReference type="OrthoDB" id="1932706at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021950">
        <property type="entry name" value="Spt20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046468">
        <property type="entry name" value="Spt20-like_SEP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13526">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPT20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13526:SF8">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPT20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12090">
        <property type="entry name" value="Spt20_SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spt20-like SEP" evidence="2">
        <location>
            <begin position="60"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
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</entry>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
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                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
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                <person name="Hietala A."/>
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                <person name="James T.Y."/>
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                <person name="Lin Y.C."/>
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                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
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                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548357.1">
        <property type="nucleotide sequence ID" value="XM_009550062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1Z5"/>
    <dbReference type="STRING" id="747525.W4K1Z5"/>
    <dbReference type="GeneID" id="20672870"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_410468"/>
    <dbReference type="eggNOG" id="KOG0104">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_5_0_1"/>
    <dbReference type="InParanoid" id="W4K1Z5"/>
    <dbReference type="OrthoDB" id="10262720at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10230">
        <property type="entry name" value="ASKHA_NBD_HSP70_HYOU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000028">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF3">
        <property type="entry name" value="HYPOXIA UP-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW79812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="30574" checksum="1061B88C8FEDFFC6" modified="2014-03-19" version="1" fragment="single">ATRFPKDTFNSLKYLLGAPANADVVSYYTTIATPTLVASTRFTVGIPKPAGKTWEVEELVAHQLAYVKHLAEEAAGERVQDVVITVPPYFTQFERDALADAVEIAGLRLLTLINDGTAVAINYAMTRSFPEPERHIIYDAGASSTRATIVTFSTGSGDAKGNSAKDTTSVTVNGIGYDRVVGGTEIDRRLREILIADFSKRYGRDIRSDPKAMAKLWKEAGRVKAILSANSEAMATIESLAYDIDFKTKVSRAALEGMCSDIKHRFAQPIYDALDEAGLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4K206</accession>
    <name>W4K206_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_419491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548385.1">
        <property type="nucleotide sequence ID" value="XM_009550090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K206"/>
    <dbReference type="GeneID" id="20673571"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_419491"/>
    <dbReference type="HOGENOM" id="CLU_050560_0_0_1"/>
    <dbReference type="InParanoid" id="W4K206"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="469" mass="51567" checksum="625E975A727425BB" modified="2014-03-19" version="1">MLLHKDHDASSPSRNSSPDVVLMVSNPDIGRVDRGTSPHPSNAGRIDRGTSPHHPEPAVVTLTPHLNNFSDDDAEDYAKFKERERTRRPSSQGAPRNASRNENPDDRNLPGSDEVPVGVSPPATIAASIGTAAQLPSHGETESIPVIQGATPPPVPTGGQIPHSMGRTTLGTNPHAGELERHADALLQRSTISAVIQMATAMALQRLANFAAGQPGNEHSDIPRRLASASLQIRGLALQTDPDTASWYEHNDGRPRALLIHPDEFSQYVNRELLPALLFTRELGAVQPSRTDPFRIVVWNVPRPGEHPTAVPNPRRAPRTVVERPSPRPRESRPTHSNPTTSPSHRVRNFPLSHGGTDEEEPPVYRRNEGRRSRGTQATLRRGTTTGGSVRHRPGTPPPSARFRTDEGQNNRSSRRTRRADSEARRNRSWTRSELDAWDALDDPGNYDDADPYYRPDEGGDGYQGPYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2F1</accession>
    <name>W4K2F1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PAN2-PAN3 deadenylation complex subunit PAN3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Poly(A)-nuclease deadenylation complex subunit 3</fullName>
            <shortName evidence="7">PAN deadenylation complex subunit 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PAN3</name>
        <name evidence="9" type="ORF">HETIRDRAFT_435179</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PAB1 (via PABC domain), conferring substrate specificity of the enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal zinc finger binds to poly(A) RNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. PAN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548435.1">
        <property type="nucleotide sequence ID" value="XM_009550140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2F1"/>
    <dbReference type="FunCoup" id="W4K2F1">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K2F1"/>
    <dbReference type="GeneID" id="20674806"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_435179"/>
    <dbReference type="eggNOG" id="KOG3741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016423_0_1_1"/>
    <dbReference type="InParanoid" id="W4K2F1"/>
    <dbReference type="OrthoDB" id="204958at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3700:FF:000001">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex subunit PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03181">
        <property type="entry name" value="PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030844">
        <property type="entry name" value="PAN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041332">
        <property type="entry name" value="Pan3_CK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272">
        <property type="entry name" value="DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272:SF11">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18101">
        <property type="entry name" value="Pan3_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="57"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Knob domain" evidence="7">
        <location>
            <begin position="359"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="320"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="198"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW79899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="451" mass="50359" checksum="FD5CEE08EC4E242E" modified="2014-03-19" version="1">MMLPPEYEVGHVMDYYPSQATFMRAPRSETFRTAPAPGLNLPEELQGYHTLVPLESTTGERRKFGSWYSTVYRATGKDDRGYVLRRIESYRLTHQAAFTAIEQWSRIGHPNIVTVHEAFTTRSFGDSSLVVAYAYHPNALTLYDAHIKPKAPIFQNGRLTAASQHLPERTIWSYIIQIASAIKAVHDKGLAVRMIDVTKILVTGKNRIRIASCGLADVLTYNPSIAAPPTPGTPSNGGSTNISQAASSVMMLLQLEDLSMLGKLIFALCCNNVAAVSNLSKAVDIVSKQYSADLKVLALFCISKPGLHKHIGQVFDMIGSRLLTEMDDLQHGIDHLEGELMSELENARLVRLLCKFGFINERPEFARDARWSETGDRYIIKLFRDYVFHQVDEHGNPVVNLSHVLACLNKLDAGTDERIMLVARDEQSVLVVSYQDVKACVESAFFELARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4K324</accession>
    <name>W4K324_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_48881</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547931.1">
        <property type="nucleotide sequence ID" value="XM_009549636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K324"/>
    <dbReference type="GeneID" id="20678089"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_48881"/>
    <dbReference type="HOGENOM" id="CLU_042941_8_0_1"/>
    <dbReference type="InParanoid" id="W4K324"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW80134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="131" mass="15074" checksum="F4188CDD774134B6" modified="2014-03-19" version="1" fragment="single">FEGEDFPYSLPMKRSSLVEIMVKESAHYSLTKPEARDEWSYNSPAGTGLVRVSPDHRTLVISMFHQLYYLRNFHEALISSTGEGPRRHVQHCLSLLRQEALCQADLALEPGDFMSRNFEEDRFGATHICRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4K338</accession>
    <name>W4K338_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_386267</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548311.1">
        <property type="nucleotide sequence ID" value="XM_009550016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K338"/>
    <dbReference type="FunCoup" id="W4K338">
        <property type="interactions" value="701"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K338"/>
    <dbReference type="GeneID" id="20672270"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_386267"/>
    <dbReference type="eggNOG" id="KOG0437">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004174_1_1_1"/>
    <dbReference type="InParanoid" id="W4K338"/>
    <dbReference type="OrthoDB" id="10249672at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07959">
        <property type="entry name" value="Anticodon_Ia_Leu_AEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000001">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055416">
        <property type="entry name" value="RBD_LARS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24810">
        <property type="entry name" value="RBD_LARS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
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            <end position="124"/>
        </location>
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            <begin position="215"/>
            <end position="775"/>
        </location>
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            <end position="936"/>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
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                <person name="Lunden K."/>
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        </location>
    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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</entry>
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    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
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                <person name="Cullen D."/>
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                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
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                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="175"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
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        </location>
    </feature>
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        <location>
            <begin position="114"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="320" mass="34751" checksum="6663FF5D38E11C70" modified="2014-03-19" version="1">MPATRSSAARRRTQISDAPYPSAPPSSPPRLDLEVIIISSDDEPDHEPTPRQHPRTARKGKGRAFHAPEEDVIDVSDSSDKKTSGQSRGSHKPSRKVKETKEACGERCSATQRAKQLEADLAKAHEERDRAQVAFKQAQLEIEAVEAAAETKIAAAKASNSQGVPIDALEDIICCEICTHKMWSPYTLSGCGHTFCQSCLSDWFSTTHVQHLAAHPAYPAHPPPVDADTYARLPAHIRAYIPQQPGPKYTCPACRQAVHRRPTESFVLKNVVRVVAAARGEHSPRKPTPAPSRATRGGRAAKAAAPAPPVDPWAGFFGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3K6</accession>
    <name>W4K3K6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_410376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548221.1">
        <property type="nucleotide sequence ID" value="XM_009549926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3K6"/>
    <dbReference type="STRING" id="747525.W4K3K6"/>
    <dbReference type="GeneID" id="20672860"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_410376"/>
    <dbReference type="eggNOG" id="ENOG502SCFZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053871_0_0_1"/>
    <dbReference type="InParanoid" id="W4K3K6"/>
    <dbReference type="OrthoDB" id="2536866at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="213" mass="23317" checksum="2EBE940E902C0BE1" modified="2014-03-19" version="1">MHILRSTYLPAYTSLLRAPYTSDPFPLSSPPPTTTTTTTTTTTTPPTSTITSTPTPDLPLLPSPHRETAILDAFIALKVREDVWADASELHLEREETFRDVFERVQPRARCEDLVRHYGERAGVVVLDAPGAADPSASGGGGSRTSRTRAIPFSALSVAFEPRRVALVLQPPAGERRRTIAEVPRAARDERLEVAAKRLVRELQAWIAEGGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3N6</accession>
    <name>W4K3N6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_49154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547938.1">
        <property type="nucleotide sequence ID" value="XM_009549643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3N6"/>
    <dbReference type="STRING" id="747525.W4K3N6"/>
    <dbReference type="GeneID" id="20678096"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_49154"/>
    <dbReference type="eggNOG" id="ENOG502S3G3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_32_0_1"/>
    <dbReference type="InParanoid" id="W4K3N6"/>
    <dbReference type="OrthoDB" id="2729552at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08284">
        <property type="entry name" value="RVP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="14316" checksum="55BC7CBAC917919B" modified="2014-03-19" version="1" fragment="single">ETTEAKILIDSGAKELLIGKQFCQKQKIPLQKIDRFIPVFNIDGMANEGGKITDKTCLLIRMTNDKGDYHNKQCELLVTNLERENVILETGWLYEHNLQIDWVKNCLMFSSCTAMCIVSQSKFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4P8</accession>
    <name>W4K4P8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_386535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548560.1">
        <property type="nucleotide sequence ID" value="XM_009550265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4P8"/>
    <dbReference type="FunCoup" id="W4K4P8">
        <property type="interactions" value="165"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K4P8"/>
    <dbReference type="GeneID" id="20672278"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_386535"/>
    <dbReference type="eggNOG" id="KOG3077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047042_0_0_1"/>
    <dbReference type="InParanoid" id="W4K4P8"/>
    <dbReference type="OrthoDB" id="27198at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF31">
        <property type="entry name" value="DCN1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCUN1" evidence="2">
        <location>
            <begin position="62"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW80036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="286" mass="32484" checksum="F79B4B3D3C0912F9" modified="2014-03-19" version="1">MSKTSKRSAEEEKILQFCGITGSSMAHAKRYLDKYKRVDIAVDAYYSEGAAAASLARPRNEPSSSKLGQLFDRYKDTDGDNITVDGTLKLCEDLGVDPEDVVLLAVAYELKSPRMAEWTRKGWIEGWKNVNADTTATMKTALLRLRDKLGSDAPYFHQVYAYTFDFARAEGQRSLSLETAQGFWALLLPHGLRGGALTHIIPRDTDGDDGMRGYEEGWREEYTSWWFEFLTERGGKGVSKDTWMMFLDFVRTIDAQFEKYDLEAAWPSTIDDFVEWAKERLASRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4Q0</accession>
    <name>W4K4Q0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Threonine/serine exporter-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_418703</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547452.1">
        <property type="nucleotide sequence ID" value="XM_009549157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4Q0"/>
    <dbReference type="FunCoup" id="W4K4Q0">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="GeneID" id="20673501"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_418703"/>
    <dbReference type="eggNOG" id="ENOG502QPMM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007078_4_3_1"/>
    <dbReference type="InParanoid" id="W4K4Q0"/>
    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/Serine exporter ThrE" evidence="8">
        <location>
            <begin position="316"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW80739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="49830" checksum="675E94003C19B898" modified="2014-03-19" version="1">MAFGAPSHRIHSQLVAACRVLAVDDSDFILIYGVTLVFFTDVDNDSSEDHIIKCTGRLELCNLHEVHTIYRHIIHEEESTNQANERLTNLLEAPPIYSVWQRCILAFGLSGFICPLAFGGSFLDTWIAGAAGAILCILQLTVFPKGVLMGNILEVAITFWISFVARALSGIKGDLFCYSAIASSAIVGVLPGYLILNSSLDLAYKNMMCGSIRLVYALVYTLFLGFGLRIGSDFYLLLDPSERRHLSMLAGEIDGKLVVNGTFFSDNSTRFDNTSPLFGTWTFFNSTSSNRDHIFKGCERPPGSVWYLQVFPWWTQLFMVPIFAICSSMANLQPWKSKEMVVMVVIACVAWTANEVVGRYIKARSDYVSFVAAMVVGLIGNIYSRRMGGTAFTSMVTGVLFLVPSGLSQNGGITGGSSVAVGGGMLSIAIGTTVGLMMSQAVVYAFGRKKSGGMFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4Q6</accession>
    <name>W4K4Q6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_434714</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547455.1">
        <property type="nucleotide sequence ID" value="XM_009549160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4Q6"/>
    <dbReference type="STRING" id="747525.W4K4Q6"/>
    <dbReference type="GeneID" id="20674768"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_434714"/>
    <dbReference type="eggNOG" id="ENOG502SEE0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044884_0_0_1"/>
    <dbReference type="InParanoid" id="W4K4Q6"/>
    <dbReference type="OrthoDB" id="21292at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF12">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="6"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="223"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW80744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="36857" checksum="8FEABC00EE5CA99A" modified="2014-03-19" version="1">MPLLAGFSIITFLLFCVFLSLFLLVSVPLTGTLVRLRANYNPKGLQLDPEDGVQPHTGPVVTGFFTMMGRVRRLEGWAGLYKGLMPTLLSNVALMLFSVLFLDASPSSPRNHGVYNAPNTSPLGVVAYSAFLMFISLPVVIITYRAVTTPHRLPYLGPFYSLRILLTPTERRRPWILYLTPGLLPAEILHIVYVVLGLRTLRHLLLPALSGPEPPRPEDISTTKLLIYLVFVIMSTIILCPLEVIATRLAVQRNHASAEYNSVSQEEEEDVDDVADYYGAEEDVIGLRSEMDPYLGLVDCGKRILIEEGWRALYRGWWITLLFGSFGAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5N1</accession>
    <name>W4K5N1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_234976</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547093.1">
        <property type="nucleotide sequence ID" value="XM_009548798.1"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K5N1"/>
    <dbReference type="GeneID" id="20668743"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_234976"/>
    <dbReference type="eggNOG" id="KOG4522">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003154_0_0_1"/>
    <dbReference type="InParanoid" id="W4K5N1"/>
    <dbReference type="OrthoDB" id="20828at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019035">
        <property type="entry name" value="Mediator_Med12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09497">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01281">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med12" evidence="8">
        <location>
            <begin position="109"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW80331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1500" mass="168027" checksum="01895C43C661EA57" modified="2014-03-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6E6</accession>
    <name>W4K6E6_HETIT</name>
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        <recommendedName>
            <fullName evidence="2">General stress protein FMN-binding split barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_418857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547612.1">
        <property type="nucleotide sequence ID" value="XM_009549317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6E6"/>
    <dbReference type="STRING" id="747525.W4K6E6"/>
    <dbReference type="GeneID" id="20673515"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_418857"/>
    <dbReference type="eggNOG" id="ENOG502RZBA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091428_0_1_1"/>
    <dbReference type="InParanoid" id="W4K6E6"/>
    <dbReference type="OrthoDB" id="434253at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052917">
        <property type="entry name" value="Stress-Dev_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038725">
        <property type="entry name" value="YdaG_split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818:SF1">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16242">
        <property type="entry name" value="Pyrid_ox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="General stress protein FMN-binding split barrel" evidence="2">
        <location>
            <begin position="23"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW80920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="204" mass="22142" checksum="B8486324B48FBCBE" modified="2014-03-19" version="1">MPDPNLDPYTSKAENNNVTPQQKITDLHKILQAAKTGMLTTRASDGHLHARAMAPAGPVSPTQLSLVFIANNTSPKCHEVQNDSHVNVSFFDNSTTNWASYSGKARLIEDRSVIKQHWSSMMAAYFGDLGDGVHKGDENDPRVIAIEVIPDEIRYWIATSGAMSRTVQTAFAAVTGKGTAPGELREITAPEIQLTQGLQSKKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6J2</accession>
    <name>W4K6J2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_248174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547405.1">
        <property type="nucleotide sequence ID" value="XM_009549110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6J2"/>
    <dbReference type="STRING" id="747525.W4K6J2"/>
    <dbReference type="GeneID" id="20669230"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_248174"/>
    <dbReference type="eggNOG" id="KOG2401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2533607_0_0_1"/>
    <dbReference type="InParanoid" id="W4K6J2"/>
    <dbReference type="OrthoDB" id="3231855at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845256" evidence="1">
        <location>
            <begin position="20"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="84" mass="9428" checksum="0D8D5A1D81C70E64" modified="2014-03-19" version="1" fragment="single">MDSIFAIGLGLALRVVVDAASQHDLRLGGSLIGLWEGAVLYHFLDKWPKSFDPYIAFVFRLFVDFLFTENLTRLTIVLLWAGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6K1</accession>
    <name>W4K6K1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_426868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546100.1">
        <property type="nucleotide sequence ID" value="XM_009547805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6K1"/>
    <dbReference type="GeneID" id="20674159"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_426868"/>
    <dbReference type="eggNOG" id="ENOG502QUPU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009065_2_0_1"/>
    <dbReference type="InParanoid" id="W4K6K1"/>
    <dbReference type="OrthoDB" id="3268677at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="874" mass="98145" checksum="02F3A9144E3C62CF" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6K4</accession>
    <name>W4K6K4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_459502</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547661.1">
        <property type="nucleotide sequence ID" value="XM_009549366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6K4"/>
    <dbReference type="STRING" id="747525.W4K6K4"/>
    <dbReference type="GeneID" id="20676998"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_459502"/>
    <dbReference type="eggNOG" id="KOG1175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_3_1"/>
    <dbReference type="InParanoid" id="W4K6K4"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002937">
        <property type="entry name" value="PRK03584.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF4">
        <property type="entry name" value="ACETOACETYL-COA SYNTHASE (AFU_ORTHOLOGUE AFUA_8G04770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="3">
        <location>
            <begin position="40"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="101"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW80975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="669" mass="73639" checksum="7700225614EA5D29" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6M7</accession>
    <name>W4K6M7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_474812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546044.1">
        <property type="nucleotide sequence ID" value="XM_009547749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6M7"/>
    <dbReference type="GeneID" id="20677585"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_474812"/>
    <dbReference type="eggNOG" id="ENOG502SYX7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073886_0_0_1"/>
    <dbReference type="InParanoid" id="W4K6M7"/>
    <dbReference type="OrthoDB" id="3241567at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="172"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW81394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="326" mass="36913" checksum="E67BD295527B32B2" modified="2014-03-19" version="1">MPSFMDRLYSRRKHDSIVLTPQAPRIQRIPLPDVGGGDMLMNSRPAMENVPPPPKPRHHHRPSMDEGYSTSPEASTSSRRPSNASRTPQAQPMKGILKHVETPIVHIARIQTDGYTSSPEKIVTSRYDSSRGRRSRLPSQPPPVSPPSVTPPVSLHWSLLPYDHHVSKSRLVFDARIPIRNISFLNTWPPRPLTTIEREKPAANPPLTEMVICCKAAPEWPVNISRPTGIRCIDVWEAIRETFDLVVTSAERNKWASRVQSGQPAFRERCRITHAPQTESMRRVDLLCGNVMFFGLEWTPPNEKYPEGSWLMRMGPSIVEPQKVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6Q4</accession>
    <name>W4K6Q4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">UDP-N-acetylglucosamine transferase subunit ALG14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Asparagine-linked glycosylation protein 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ALG14</name>
        <name evidence="13" type="ORF">HETIRDRAFT_45766</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Heterodimer with ALG13 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ALG14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546931.1">
        <property type="nucleotide sequence ID" value="XM_009548636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6Q4"/>
    <dbReference type="FunCoup" id="W4K6Q4">
        <property type="interactions" value="138"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K6Q4"/>
    <dbReference type="GeneID" id="20676855"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_45766"/>
    <dbReference type="eggNOG" id="KOG3339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064541_0_1_1"/>
    <dbReference type="InParanoid" id="W4K6Q4"/>
    <dbReference type="OrthoDB" id="17098at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013969">
        <property type="entry name" value="Oligosacch_biosynth_Alg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154:SF4">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08660">
        <property type="entry name" value="Alg14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844327" description="UDP-N-acetylglucosamine transferase subunit ALG14" evidence="12">
        <location>
            <begin position="19"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW80741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="217" mass="24301" checksum="F29576F2FDF2FB4C" modified="2014-03-19" version="1">MTLAVILLLLSRVYFLRRERNLPRVRRSGTCSLAVFLGSGGHTMEALSLVNSLDFTRYTPRTYIVSEGDALSIQKARALERLKLSRNEIVAIGEYRVITIPRARHVHQKLFQTVPTALLSLLVSFYHVTVAPFFAAPISEVLLLNGPGTCFVLCIATYLNRLLGLPSPKLIYVESFARVKTLSLSGRLLRSMVDSFVVQWPDLLKEGGRGVYHGWLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6Y2</accession>
    <name>W4K6Y2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CoA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_440624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547779.1">
        <property type="nucleotide sequence ID" value="XM_009549484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6Y2"/>
    <dbReference type="STRING" id="747525.W4K6Y2"/>
    <dbReference type="GeneID" id="20675285"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_440624"/>
    <dbReference type="eggNOG" id="ENOG502S3ZG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112567_1_1_1"/>
    <dbReference type="InParanoid" id="W4K6Y2"/>
    <dbReference type="OrthoDB" id="5138418at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303:SF2">
        <property type="entry name" value="COA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303">
        <property type="entry name" value="CYTOPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="141" mass="15155" checksum="A563BBBD0091295B" modified="2014-03-19" version="1">MVLTSEIQKLFLSSPKFAVVGASKDTSKYGTKVLKWYQARDKLVTPVHPKESELEGITAVRTLGDLATPSETSVSIITNPKVTLGLLEQAKALSVPALWLQPGAEDEAVISYIKDNGLSDKVIYGGPCILVEGDNVIKSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7A8</accession>
    <name>W4K7A8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_440671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547881.1">
        <property type="nucleotide sequence ID" value="XM_009549586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7A8"/>
    <dbReference type="GeneID" id="20675293"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_440671"/>
    <dbReference type="HOGENOM" id="CLU_838253_0_0_1"/>
    <dbReference type="InParanoid" id="W4K7A8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW81220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="332" mass="37054" checksum="ED10B552EF2E18BE" modified="2014-03-19" version="1" fragment="single">MEMRRARARRVAREAGSVAGGRRRSVRGRGAGAQVPARARCRPDETRRSRRRLGFCLFLLLLIMSFLVVVALASDLSPHAHSPALSLFDPHFSLSLSAARGHHARSHLDGIYSPIHPAFLFLGYTLGKRDARPLRLERLRVLCPVPSCSAISRRRLPYIAHPRRRGERTDPMLPRTLLRTLLRRHTPHHAHDCMTLDVDFFFCLPTLLLRCDAMGCGRAQIGCWAALGRARRVRSAPVVPSGSSPPGLALLHRLLAAVTPTAAGWLAGRKADTRVRIRTHMFFFYGLRLTRYTIYTIEASGYVGRAFMTVCVCTVDCLVRVCVLIHACVVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7L3</accession>
    <name>W4K7L3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_125200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546369.1">
        <property type="nucleotide sequence ID" value="XM_009548074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7L3"/>
    <dbReference type="STRING" id="747525.W4K7L3"/>
    <dbReference type="GeneID" id="20666900"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_125200"/>
    <dbReference type="eggNOG" id="KOG0596">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="InParanoid" id="W4K7L3"/>
    <dbReference type="OrthoDB" id="20524at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033316">
        <property type="term" value="P:meiotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14131">
        <property type="entry name" value="PKc_Mps1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000131">
        <property type="entry name" value="Dual specificity protein kinase TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000224">
        <property type="entry name" value="serine/threonine-protein kinase mph1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027084">
        <property type="entry name" value="Mps1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF21">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW81759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="275" mass="31451" checksum="454AC285EF51A518" modified="2014-03-19" version="1">MIGKGGSSRVYRVMNNANEIYAIKRVSLDKTDPETMSGYMNEIALLKRLEGNSRIIRLIDSEVRRGPGGSRGYLMLVMECGEIDLARLLQERQKEPLNLVWVAYYWQQMLEAVLVIHHEKIVHSDLKPANFVLVRGQLKLIDFGIANAIANDTTNIQRDHQIGTVNYMSPEAIELPDGQRRLKVGRSSDVWSLGCILYQMIYFQTPFQHLSVYQKMKAIPDMSYEIDFPAYSAPIRKVKSDAIACMKACLCRNPKKRTPIEVLLKQDWINIQDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4K907</accession>
    <name>W4K907_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_105110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546421.1">
        <property type="nucleotide sequence ID" value="XM_009548126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K907"/>
    <dbReference type="GeneID" id="20666045"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_105110"/>
    <dbReference type="HOGENOM" id="CLU_1859991_0_0_1"/>
    <dbReference type="InParanoid" id="W4K907"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="138" mass="15259" checksum="CBC381B4A68FE6D6" modified="2014-03-19" version="1" fragment="single">MDNSAHYDPLAFSQYSPHRPLDSAISLSSWHHHQHSPTSASSPPDQSRMYPIINNPINHIDYTSPQFVHQPPSAFLPQHDDDPSLNPSHALNLDAPQLQSSIGPTRVLTRRQRAAQAHPHPARPGPVNDLGLSGENHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9H9</accession>
    <name>W4K9H9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_57868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544684.1">
        <property type="nucleotide sequence ID" value="XM_009546389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9H9"/>
    <dbReference type="STRING" id="747525.W4K9H9"/>
    <dbReference type="GeneID" id="20678413"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_57868"/>
    <dbReference type="eggNOG" id="ENOG502S5IV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033666_12_2_1"/>
    <dbReference type="InParanoid" id="W4K9H9"/>
    <dbReference type="OrthoDB" id="2417635at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="2"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="104" mass="11549" checksum="864DFA4AA9BCF500" modified="2014-03-19" version="1">MLVVEDGAPAHTSHLTKSARLKLGITPLTHPPSSPDLNPIEPLWLLLKNCVADTPGASNSLENLWLAAQHAWEEITEEGIQRHTRKMSERVAQVQAAKGWHTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAY3</accession>
    <name>W4KAY3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aspartic peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_127258</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544881.1">
        <property type="nucleotide sequence ID" value="XM_009546586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAY3"/>
    <dbReference type="GeneID" id="20666982"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_127258"/>
    <dbReference type="eggNOG" id="ENOG502S58F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014988_0_0_1"/>
    <dbReference type="InParanoid" id="W4KAY3"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF57">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="8"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="447"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="697"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW82525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="717" mass="75062" checksum="B3CE476E6A116D1F" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCQ8</accession>
    <name>W4KCQ8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_425282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543347.1">
        <property type="nucleotide sequence ID" value="XM_009545052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCQ8"/>
    <dbReference type="GeneID" id="20674027"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_425282"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028281_2_1_1"/>
    <dbReference type="InParanoid" id="W4KCQ8"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="101"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="415" mass="45392" checksum="14E9CF9662EB5AFD" modified="2014-03-19" version="1">MRPVWFGTDRRKAPTRDVLVLQGGLGQGCQRKYWDVHKPICRRVTRRATSAATEGLILATLPIPSPSLKGDTTQCILYPGLKDRILSQPGFPQSIPEPTSPAHRLGSVPGAGIGMYATRAIAAGELIITERPLLVAPGTYNSPRQRDDTIAAALERMSEDDRAAYTALSNPRDAAVPPLFAIWKTNNYDQTHDLGPASSEMAADAQHPMTIIGKLTSRINHSCSPNATIAWHVLSLALFVTAVCDIPAGAEISMHYCEPLLPSAERQQFLRANYGFTCACADPAVSDVRRAGIMQHGYFLEDRAATLARWIGDATLRDDHPTEPLRAMLALIAEEGVQDAEIHPMALKLLVDVYAACGDAEKLAEYAAWFAVAGASAIYVPLRRRQEMVRDLSRPGLYPFWNKRVEYRGPNAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4KD64</accession>
    <name>W4KD64_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_439708</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545536.1">
        <property type="nucleotide sequence ID" value="XM_009547241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KD64"/>
    <dbReference type="FunCoup" id="W4KD64">
        <property type="interactions" value="363"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KD64"/>
    <dbReference type="GeneID" id="20675180"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_439708"/>
    <dbReference type="eggNOG" id="KOG0371">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_8_1_1"/>
    <dbReference type="InParanoid" id="W4KD64"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="109"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW83265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="304" mass="34933" checksum="BE826180A9171E50" modified="2014-03-19" version="1">MEHEIDGWIQQLSQCKQLSEADVKKLCEKTREILMEESNVQPVRCPVTVCGDIHGQFHDLSELFRIGGNSPDTNYLFMGDYVDRGYYSVETVTLLVAMKLRYRERVTILRGNHESRQITQVYGFYDECLRKYGNANVWRYFTDLFDYLPLTALIENQIFCLHGGLSPSIDTLDHVRSIDRVQEVPHEGPMCDLLWSDPDDRCGWGISPRGAGYTFGQDISEAFNHNNGLTLVARAHQLVMEGYNWGQDRNVVTIFSAPNYCYRCGNQAAIMEIDEKLSYSFLQFDPAPRAGEPLVTRRVPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDG4</accession>
    <name>W4KDG4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_119479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545617.1">
        <property type="nucleotide sequence ID" value="XM_009547322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDG4"/>
    <dbReference type="GeneID" id="20666652"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_119479"/>
    <dbReference type="HOGENOM" id="CLU_1372364_0_0_1"/>
    <dbReference type="InParanoid" id="W4KDG4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="199" mass="22326" checksum="B29FE0FA3E821924" modified="2014-03-19" version="1">MSSPVNDHDALSITSTVRPLLPSLELRPNPVEQQLRQHTRALIFMMSIWYTKDGGLDSQTTGTQCEAILTHRTDKKTHRKAGPQSIEVGSETAHSSPIRLGDTEGLRVCAEYYEDSEESASAAPNALHNFPFCEILDELRNLHIELCAMHVYVQALEGILRKLDISIPRPPAADEGLEAVYKDWDPPLLEGMRARWKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDI4</accession>
    <name>W4KDI4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_313109</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543540.1">
        <property type="nucleotide sequence ID" value="XM_009545245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDI4"/>
    <dbReference type="FunCoup" id="W4KDI4">
        <property type="interactions" value="623"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KDI4"/>
    <dbReference type="GeneID" id="20670005"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_313109"/>
    <dbReference type="eggNOG" id="KOG2175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032677_0_0_1"/>
    <dbReference type="InParanoid" id="W4KDI4"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055236">
        <property type="entry name" value="EVH1_PP4R3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22972">
        <property type="entry name" value="EVH1_PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PP4R3 EVH1-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central" evidence="3">
        <location>
            <begin position="130"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW83794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="543" mass="60414" checksum="5AE52C5B4F6CF927" modified="2014-03-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEB4</accession>
    <name>W4KEB4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_155388</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
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        <property type="protein sequence ID" value="ETW84192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009545595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEB4"/>
    <dbReference type="STRING" id="747525.W4KEB4"/>
    <dbReference type="GeneID" id="20667568"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_155388"/>
    <dbReference type="eggNOG" id="KOG1342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_7_4_1"/>
    <dbReference type="InParanoid" id="W4KEB4"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF2">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HDASUPER"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW84192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="547" mass="62143" checksum="4242B7341CAF5F93" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEU7</accession>
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        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
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    </protein>
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        <name evidence="11" type="ORF">HETIRDRAFT_381847</name>
    </gene>
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            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
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            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
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                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
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                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11 12">TC 32-1</strain>
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    <dbReference type="HOGENOM" id="CLU_539871_0_0_1"/>
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    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
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        <location>
            <begin position="90"/>
            <end position="328"/>
        </location>
    </feature>
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        <location>
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            <end position="555"/>
        </location>
    </feature>
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        <location>
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            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="273"/>
        </location>
    </feature>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW84358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4KF94</accession>
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    </protein>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009545408.1"/>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_432982"/>
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    <dbReference type="HOGENOM" id="CLU_438755_0_0_1"/>
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    <dbReference type="OrthoDB" id="3351491at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="519"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW83980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="623" mass="68803" checksum="00881286E61E3A4C" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFA4</accession>
    <name>W4KFA4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_146703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543712.1">
        <property type="nucleotide sequence ID" value="XM_009545417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFA4"/>
    <dbReference type="STRING" id="747525.W4KFA4"/>
    <dbReference type="GeneID" id="20667156"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_146703"/>
    <dbReference type="HOGENOM" id="CLU_1209964_0_0_1"/>
    <dbReference type="InParanoid" id="W4KFA4"/>
    <dbReference type="OrthoDB" id="3268641at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="229" mass="25167" checksum="5AA52743985F457F" modified="2014-03-19" version="1">MERRGRATYARPTYDDRRQSDQHAVYLNPARSHAGSSSIPRSDSASRSHTASPSPRAPSMYSNQSSSEDVRLREGRNSRRASMASESSPLPTYPSMPMIPVMPQYVMDMPLLPPAAPFMRQQHGQRPRSSNSPSPARGSLPNSHSSDRIHQPSPHLSAPQHGHHRHSSSDDYRRRDSSGSHGGPPSEGSGSSLGRPPPPRQQSLLLGPTTPSYFSQNRPSSYRRSTAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
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    <name>W4KFT9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_438905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543645.1">
        <property type="nucleotide sequence ID" value="XM_009545350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFT9"/>
    <dbReference type="STRING" id="747525.W4KFT9"/>
    <dbReference type="GeneID" id="20675088"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_438905"/>
    <dbReference type="eggNOG" id="ENOG502SUKN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096586_0_0_1"/>
    <dbReference type="InParanoid" id="W4KFT9"/>
    <dbReference type="OrthoDB" id="3217075at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="192" mass="21105" checksum="1864360F4B1102C9" modified="2014-03-19" version="1">MSSSPLSSDIKPIISPPMHDIHLLPTPPSSPLPDVAAHTSVVLLNSLVQFYQQESLWVHRTRAALELALSTRGIDSPGTPAQIPSGPTPPSSDTDDAVKQDPSTPQPIGKAHSLSRWMQRKKSFKLKLEGMPNSLAAARRRRAHRGAHAPTAPETGTRLLELFGQLMEARMESCHRVHRLVQEAHCPDLYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFX8</accession>
    <name>W4KFX8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_473480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544379.1">
        <property type="nucleotide sequence ID" value="XM_009546084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFX8"/>
    <dbReference type="STRING" id="747525.W4KFX8"/>
    <dbReference type="GeneID" id="20677516"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_473480"/>
    <dbReference type="eggNOG" id="ENOG502SJJG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017400_0_0_1"/>
    <dbReference type="InParanoid" id="W4KFX8"/>
    <dbReference type="OrthoDB" id="2742205at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="473" mass="52946" checksum="12016D9DE4D18660" modified="2014-03-19" version="1" fragment="single">MTSTPPLASSSRSPLLSAKVSEIYQKLPIDAQKELIDNYLLPLLDAAPKERARQVLAVAAKREKRYAGMPKLEHDAWAIELNDLMLELDKDQKLSLLKDRSRRDEIVGEMVDSMIGWMNDIWSVVYEYQANFALAHRCLLLVARTISALSPHHGGCGCAFRNMYISAVIKQKSGKTIKAFQLTGAHKINKVLQWIWRDLFLTLLATGSEAQKKQVPDMLQAIDRAMGWTSLEYILTGGRVVTGSDEDVDEDEDVDDCDDDTDFGDDDDAWEDDDSEDEDFRDHARKCPFHADHWSLSASAQMIPLRYLVEQHLTNVFSLTPNPSLYRAVLRVTSNYEIARFQLIELARVGALTCSESFVGALNVFTTESRPDLICRLLDKGSHLLRPRDASALQDAILVVSANRTFGSRAVPMIERELLDTARAIKAGLLASFSHLSDPAKIVEMKTIAALPEGSLARQARVEQWIDSVMSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGP8</accession>
    <name>W4KGP8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DEAD-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_472743</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543923.1">
        <property type="nucleotide sequence ID" value="XM_009545628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGP8"/>
    <dbReference type="FunCoup" id="W4KGP8">
        <property type="interactions" value="404"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KGP8"/>
    <dbReference type="GeneID" id="20677476"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_472743"/>
    <dbReference type="eggNOG" id="KOG0340">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_1_1"/>
    <dbReference type="InParanoid" id="W4KGP8"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17955">
        <property type="entry name" value="DEADc_DDX49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="14"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="251"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="230"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW84231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="49737" checksum="DCD83DE9EA6383F2" modified="2014-03-19" version="1">MSIRAPTEVQTACVPPLLAGEDCIGNAKTGSGKTMAFALPILQKLSVDPYGIFALVLTPTRELAFQISEQFAVLGAPLNVRTAVVVGGMDMMAQALELGNRPHVVVATPGRIVDHLRSGSGEWDLSRVKFLVLDEADRLLTSTFSADMAHIFSVLPKDRQTALFTATWTPSIETIADAPPRPGKQKPFVHRMVASTETVESLKQYYILVPSHVRESYLYHLLCNPPESTLHLRRAAPEPSKTSRKPRSKPKGAQKKAQVEDEPAQPPPTMIFCARPRTAAYLTYLLKTLSIRSTALHSRLTQRERLNSLQLFRSSVVPVLVCTDVGARGLDIEDVALVVNWDLTDEPEEYTHRVGRTARAGRGGVAISFVSERDEGRVLKIEDRIKTRLSEMELPEDKVLEHLNRVSTARRLANMELHDSNFGQREQIHQAKNRARLQGQGGDGLAPPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGW8</accession>
    <name>W4KGW8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_439399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544580.1">
        <property type="nucleotide sequence ID" value="XM_009546285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGW8"/>
    <dbReference type="GeneID" id="20675140"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_439399"/>
    <dbReference type="HOGENOM" id="CLU_2242909_0_0_1"/>
    <dbReference type="InParanoid" id="W4KGW8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="105" mass="11314" checksum="5A76820D10E391B2" modified="2014-03-19" version="1" fragment="single">VEGQWSGVCEEWAEERARISSAREDWEARVRAAEEGFDGAVAKVDAGLATLQQHTSSRQTGTRATASGSSRLPVRAVSRLTRASVIGGNGRRPPGADRVRTRPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KH34</accession>
    <name>W4KH34_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_170843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544027.1">
        <property type="nucleotide sequence ID" value="XM_009545732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KH34"/>
    <dbReference type="GeneID" id="20668308"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_170843"/>
    <dbReference type="HOGENOM" id="CLU_3068941_0_0_1"/>
    <dbReference type="InParanoid" id="W4KH34"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="53" mass="5773" checksum="E0DB4F2FC9EDCC6E" modified="2014-03-19" version="1">MPACIPLLPTTCPPACLSSYLRVYLSSPPPRLQYPRARRSPPAARRPPNSSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4KH96</accession>
    <name>W4KH96_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_438153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541975.1">
        <property type="nucleotide sequence ID" value="XM_009543680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KH96"/>
    <dbReference type="STRING" id="747525.W4KH96"/>
    <dbReference type="GeneID" id="20675017"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_438153"/>
    <dbReference type="eggNOG" id="ENOG502T0TS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_723734_0_0_1"/>
    <dbReference type="InParanoid" id="W4KH96"/>
    <dbReference type="OrthoDB" id="3256408at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="382" mass="41860" checksum="86B00DF7E71964BC" modified="2014-03-19" version="1">MSNTHDHLDLSRFPDHLGCSTGSLTHVFSDDSSQHHMDFDDTDMSPASPRQLTSHFPGLGFSAQTGSEDLDLELAPYSPSRRNFTLLPAMDEDEDEFPDTPQPSSPSSPSRRSFASLPDIDMDDTISPSHPTPSPRLLSLPGADTDDDLLLPAFSYIPNSEPPPPDGPSLGLFVPIAVAEEPHIADSPPEEEPDLNFSWDARARVDAAELDKLVALRRRAWFLERNAKRTEQSYAEEAQRIAAGLRVSPPVPGALADVQLQAGLDPKGAIRRELQVAEARRAEARRVRKKEKERGKEVQAMLRLKLDDGVGAGTPEAPADAVVQRDERGKVVIGSFSQLVARMIFKRRDASRVLANKKTPGDYVCSSLSRGVSPDFEDVNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHT1</accession>
    <name>W4KHT1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_48509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543240.1">
        <property type="nucleotide sequence ID" value="XM_009544945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHT1"/>
    <dbReference type="GeneID" id="20678070"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_48509"/>
    <dbReference type="HOGENOM" id="CLU_2819471_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHT1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW84636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="67" mass="7720" checksum="65461B49A6AB6D6E" modified="2014-03-19" version="1" fragment="single">EYTYNIYQHLATKKSPLELLHGYQPQAYLAIIRNINVPTTNTYLQALQCARKEAQANLKIIAEAMRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIB9</accession>
    <name>W4KIB9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Serine protease S53</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_115474</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541951.1">
        <property type="nucleotide sequence ID" value="XM_009543656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIB9"/>
    <dbReference type="STRING" id="747525.W4KIB9"/>
    <dbReference type="GeneID" id="20666485"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_115474"/>
    <dbReference type="eggNOG" id="ENOG502QR6D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013783_3_1_1"/>
    <dbReference type="InParanoid" id="W4KIB9"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF15">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844268" evidence="10">
        <location>
            <begin position="18"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="11">
        <location>
            <begin position="214"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW85060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="560" mass="59145" checksum="C1E9B787BA69EB7A" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4KID9</accession>
    <name>W4KID9_HETIT</name>
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        <recommendedName>
            <fullName evidence="7 18">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="6 18">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HETIRDRAFT_407577</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines. Negatively regulates the biosynthesis of acetyl-CoA from pyruvate in the mitochondrion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 19">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="6 18"/>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542462.1">
        <property type="nucleotide sequence ID" value="XM_009544167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KID9"/>
    <dbReference type="FunCoup" id="W4KID9">
        <property type="interactions" value="425"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KID9"/>
    <dbReference type="GeneID" id="20672611"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_407577"/>
    <dbReference type="eggNOG" id="KOG1367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025427_0_2_1"/>
    <dbReference type="InParanoid" id="W4KID9"/>
    <dbReference type="OrthoDB" id="275353at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF0">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="63"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="372"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00016471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ETW85622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="416" mass="44313" checksum="A3E677ED55535FC6" modified="2014-03-19" version="1">MSLSNKLAVTDLDLTGKRVLIRVDFNVPMQDGKITNPARIVAALPTIKYALENGASTVILMSHLGRPDGRPNSKYSLEPVSHELSKLISKPVTFLSDCVGPDVEKAVSSATQGSVILLENLRFHIEEEGSVKNKDGTKTKADPAKVTEFREGLTKLGDVYVNDAFGTAHRAHSSMVGIKLPQRAAGFLVKKELEFFAKALESPERPFLAILGGAKVSDKIQLIDNMLDKVDSLIICGGMAFTFKKTLEGVSIGDSLFDAPGSEKVASLIEKAKKNNVKLVFPVDYITADKFDKNANTGIASDVDGIPDGWMGLDAGPKSREIYRQAVLEAKTILWNGPPGVFEFPAFAEGSKSLLNANVTAAQNGSVVIVGGGDTATVVAQYDAEDKLSHVSTGGGASLELLEGKTLPGVAELSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIH1</accession>
    <name>W4KIH1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_109291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009546174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIH1"/>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_109291"/>
    <dbReference type="HOGENOM" id="CLU_1151909_0_0_1"/>
    <dbReference type="InParanoid" id="W4KIH1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="241" mass="25495" checksum="73C9DD05214B843C" modified="2014-03-19" version="1">MRKASPKAQFQGVANKTNGNTASTDSIEAHHSGARNLLSKFNHDHHDLPTAHLYLNSIHTHHGNHIGHAPHVCSVIGPFLPHSIHRHAPHPSTPLPAPSAGLCIVLDTAAVPDDSALNPLIPMPISAPTLFTLSTPTTCPISTSMSVSVPVVSIPALEIVTAPQDMRPRIPPANANALHRRQGADTLTTTQTHTAAALVPSQGNFARNFAVASPECEFVDLHTSFAFPLHLMGFVSGATSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIP3</accession>
    <name>W4KIP3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aspartic peptidase DDI1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_43076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541764.1">
        <property type="nucleotide sequence ID" value="XM_009543469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIP3"/>
    <dbReference type="GeneID" id="20674477"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_43076"/>
    <dbReference type="eggNOG" id="ENOG502S3G3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_32_0_1"/>
    <dbReference type="InParanoid" id="W4KIP3"/>
    <dbReference type="OrthoDB" id="3267566at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11349" checksum="B6EDB9F944F787C1" modified="2014-03-19" version="1">MCINVQLKHKKGTTEAKVLIDSGIEGLLIDKQFCQKQGIPLQKIDRFIPVFNVDGMANEGRKITNKACLLMRMTNDKGDYHDEQCKLLATNLGGEDVILGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIW6</accession>
    <name>W4KIW6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_448778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542602.1">
        <property type="nucleotide sequence ID" value="XM_009544307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIW6"/>
    <dbReference type="GeneID" id="20675887"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_448778"/>
    <dbReference type="HOGENOM" id="CLU_557836_0_0_1"/>
    <dbReference type="InParanoid" id="W4KIW6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="489" mass="53493" checksum="71156895DDAB1F38" modified="2014-03-19" version="1">MHRANRQRVSNPLPSDRLRTLPRHLSLRPPASQSQTHSLSAPAAGISPSHPHPSVPSHITNSLSFPTQLVPIQSPPPLILPSRHSMLRYPSLPFQASPITVPHVTTLTAANAGPRPIVPSATHPIGRPARSQLLKIALTSLRCPCPPSLALFSPFAHATNIPRASRDERSDLPARVPTQSRLTRTRPDIMHHAPASAQRSDRRNVRPQPRTIIRPLCRARSPHPSPLHFLAHDAPRWAAHAASLSITSLSHSYRTRHARTLAKHDPASFALLRPASSGNLQTPPSTTASPHAYKPRHTPPHPASPRSPIGSDAALLTCGILHGFCPSRAVLLERRLHPTPDNKPFEALGSPWNAFEDATRRDDGRSRDPTRRTPWAGARPRAGAVPPSHRERKENTLGGRYSSLSLTLRADAYAPSVDLCGPSPRTRVPFVDPLVPIVIVTVFVAFSPSSQRSDPLARAYVPPTHDPDLQRVFVRRASVPSSGLRRPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJE1</accession>
    <name>W4KJE1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_414289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542061.1">
        <property type="nucleotide sequence ID" value="XM_009543766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJE1"/>
    <dbReference type="GeneID" id="20673164"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_414289"/>
    <dbReference type="HOGENOM" id="CLU_169134_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJE1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="94" mass="10743" checksum="0E5A3874E1DEF3E2" modified="2014-03-19" version="1">MGEAMSVMEVDTTVVENEADIFARYTLAMPLFVRLLFHPQFSHAITQNFLLVTLPRNDGPSILFTALTALHQMTYAGFFVHLNDMLSVLRLRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4KK33</accession>
    <name>W4KK33_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Presequence translocated-associated motor subunit PAM17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_308993</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the PAM complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the PAM17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542967.1">
        <property type="nucleotide sequence ID" value="XM_009544672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KK33"/>
    <dbReference type="FunCoup" id="W4KK33">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KK33"/>
    <dbReference type="GeneID" id="20669633"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_308993"/>
    <dbReference type="eggNOG" id="ENOG502S1B1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068297_2_0_1"/>
    <dbReference type="InParanoid" id="W4KK33"/>
    <dbReference type="OrthoDB" id="5970083at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013875">
        <property type="entry name" value="Pam17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021:SF1">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08566">
        <property type="entry name" value="Pam17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW86207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="168" mass="18999" checksum="54C27F3D9D0B2A30" modified="2014-03-19" version="1">MVLARRANSTLPQSTKENLPWPEYLAIRRAKRRWEMALTIPCMAAGLVGGAAYFGSLEVDASKPIMGLDPIFFFGGATLGCVGLGYLIGPIIGSTCWRLTHRRTMALIEARDREFHSRIVKNRVDPTAQSATNPVPDFYGEKIGSLHEYRQWLRDQAKYKRKSEWPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKQ4</accession>
    <name>W4KKQ4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase family 13 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_145926</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542486.1">
        <property type="nucleotide sequence ID" value="XM_009544191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKQ4"/>
    <dbReference type="STRING" id="747525.W4KKQ4"/>
    <dbReference type="GeneID" id="20667106"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_145926"/>
    <dbReference type="eggNOG" id="KOG0471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1179991_0_0_1"/>
    <dbReference type="InParanoid" id="W4KKQ4"/>
    <dbReference type="OrthoDB" id="204980at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF215">
        <property type="entry name" value="ALPHA-AMYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844307" evidence="5">
        <location>
            <begin position="19"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="6">
        <location>
            <begin position="31"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW85651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="191" mass="21309" checksum="B832995E9A0607F8" modified="2014-03-19" version="1" fragment="single">MHALTASFVLSLMGSALAATAAEWRGRSIYQIITDRYALPSGANTNACDPGQQTWCGGTWNTIRENLDYIQDAGFTAIWISPVSQNYEGPRTAYGDPYHGYWVADATKLNSRYGTSDDLKALSDELHRRNMFLMVDVVANNVMATSTTPDLSTYMFKDQSQYHPYCPVDWNNITSIQECWLGDTKVALPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKU3</accession>
    <name>W4KKU3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_165988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540492.1">
        <property type="nucleotide sequence ID" value="XM_009542197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKU3"/>
    <dbReference type="STRING" id="747525.W4KKU3"/>
    <dbReference type="GeneID" id="20668027"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_165988"/>
    <dbReference type="HOGENOM" id="CLU_1343414_0_0_1"/>
    <dbReference type="InParanoid" id="W4KKU3"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="204" mass="23142" checksum="DDB5D49454251DB4" modified="2014-03-19" version="1">MIASEIICDDTYPYNAWCTVSQGVLTLREINQMECEMCSYLGCQINVKPSVLCNFEPLSCSCRRPPPSRTPSPPHLHLLPHVWPADTLQHRQGAGRCCVAVVSYTPLYVQVRVDLLVTHVTRRHFLHPPHLHTFLWAAYILFQVYAARVHALIHLTHTQFRDAHPVALNLDVHPSSHAPFTSASTFRLQTSFVGFSASTCRRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLE1</accession>
    <name>W4KLE1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Nuclear proteasome inhibitor UBLCP1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_43143</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
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        <reaction evidence="10">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
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            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541767.1">
        <property type="nucleotide sequence ID" value="XM_009543472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLE1"/>
    <dbReference type="STRING" id="747525.W4KLE1"/>
    <dbReference type="GeneID" id="20674534"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_43143"/>
    <dbReference type="eggNOG" id="KOG1605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046931_1_0_1"/>
    <dbReference type="InParanoid" id="W4KLE1"/>
    <dbReference type="OrthoDB" id="1711508at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090364">
        <property type="term" value="P:regulation of proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011943">
        <property type="entry name" value="HAD-SF_hydro_IIID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051658">
        <property type="entry name" value="UBLCP1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02245">
        <property type="entry name" value="HAD_IIID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48493">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48493:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="12">
        <location>
            <begin position="11"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="FCP1 homology" evidence="13">
        <location>
            <begin position="144"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW86175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="337" mass="38654" checksum="EE65DEDA64E51976" modified="2014-03-19" version="1">MQDDTITERWIHLAFSWASKAFTLDVAESDRVFDLKAALFSLTNVPPERQKILGLVKGKLPPDEERVGNLKLVSSKKFTLVGTPEGHEIKDPSQVEFLPDILNDLDVDFSMDPAAAIQYQNDQRNMRKIREATKRLNVNIIHPLREGKRLLVLDIDYTILDTKPLTSGALPPAECARPRLHEFLSAIYPYYDICIWSQTSWIWLETKLVELGMLGTDRPYKVSFVLDKTSMFTVFSTREGKTYTHSVKALQIIWNRFPQFNAQNTIHVDDLGRNFALNPKQGLKISAFKEAHTPQAMADRELDKLARYMVHIADVDNFQALDHKDWKRVVRALHPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4KN17</accession>
    <name>W4KN17_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_30910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540289.1">
        <property type="nucleotide sequence ID" value="XM_009541994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KN17"/>
    <dbReference type="STRING" id="747525.W4KN17"/>
    <dbReference type="GeneID" id="20669642"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_30910"/>
    <dbReference type="eggNOG" id="ENOG502SIM9">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_365696_0_0_1"/>
    <dbReference type="InParanoid" id="W4KN17"/>
    <dbReference type="OrthoDB" id="268763at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW87104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="755" mass="83020" checksum="BF9657D161371286" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>W4KND2</accession>
    <name>W4KND2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2 10">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_153508</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2 10"/>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540574.1">
        <property type="nucleotide sequence ID" value="XM_009542279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KND2"/>
    <dbReference type="FunCoup" id="W4KND2">
        <property type="interactions" value="448"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KND2"/>
    <dbReference type="GeneID" id="20667436"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_153508"/>
    <dbReference type="eggNOG" id="KOG0660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="W4KND2"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07856">
        <property type="entry name" value="STKc_Sty1_Hog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000049">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000050">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038783">
        <property type="entry name" value="MAPK_Sty1/HOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="346"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW86566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="378" mass="42393" checksum="7F9002C4895AC002" modified="2014-03-19" version="1">MSFVKLSIFGTSFEVTTRYVDLQPVGMGAFGLVCSAKDQLTGASVAVKKIMKPFSTPVLSKRTYRELKLLKHIQHENIISLRDVFISPLEDIYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQILRGLKYVHSAGVVHRDLKPSNILVNENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVAVDIWSTGCIFAEMLEGKPLFPGKDHVNQFSIITELLGTPPDDVIETICSENTLRFVQSLPKRDRVPFSEKLRCSDESALDLLEKMLVFDPRKRIDATASLAHEYVGPYHDPTDEPVAGEKFDWSFNDADLPVDTWKVMMYSEILDFHQVSDSTASTTANGVPEGALAGPDDGGAPTANGSAPHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNK1</accession>
    <name>W4KNK1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_431738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541294.1">
        <property type="nucleotide sequence ID" value="XM_009542999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNK1"/>
    <dbReference type="FunCoup" id="W4KNK1">
        <property type="interactions" value="951"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KNK1"/>
    <dbReference type="GeneID" id="20674559"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_431738"/>
    <dbReference type="eggNOG" id="KOG2081">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005996_0_1_1"/>
    <dbReference type="InParanoid" id="W4KNK1"/>
    <dbReference type="OrthoDB" id="435593at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057941">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058537">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF53">
        <property type="entry name" value="MRNA TRANSPORT REGULATOR MTR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24138">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24140">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24139">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="1">
        <location>
            <begin position="26"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="932" mass="102782" checksum="D6400D7CCFC62083" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNT3</accession>
    <name>W4KNT3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HETIRDRAFT_306858</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540706.1">
        <property type="nucleotide sequence ID" value="XM_009542411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNT3"/>
    <dbReference type="FunCoup" id="W4KNT3">
        <property type="interactions" value="585"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KNT3"/>
    <dbReference type="GeneID" id="20669438"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_306858"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_59_3_1"/>
    <dbReference type="InParanoid" id="W4KNT3"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12122">
        <property type="entry name" value="AMPKA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001222">
        <property type="entry name" value="Serine/threonine-protein kinase ppk25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032270">
        <property type="entry name" value="AMPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013896">
        <property type="entry name" value="SNF1_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16579">
        <property type="entry name" value="AdenylateSensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08587">
        <property type="entry name" value="UBA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="18"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETW86711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="641" mass="72008" checksum="4224AF0842CBE1D8" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNT9</accession>
    <name>W4KNT9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4220 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_413101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540711.1">
        <property type="nucleotide sequence ID" value="XM_009542416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNT9"/>
    <dbReference type="GeneID" id="20673090"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_413101"/>
    <dbReference type="HOGENOM" id="CLU_1695698_0_0_1"/>
    <dbReference type="InParanoid" id="W4KNT9"/>
    <dbReference type="OrthoDB" id="3346544at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17351" checksum="81020D8A5D066F0E" modified="2014-03-19" version="1">MWSLATAHIAIDLHRGLLVFVNGDVGYFDDFSQPLSYARNTIYFVQALLGDAVLVWRCYVLCNRRVVIVALPLLSMLGCLFIAFGSGVIWSRYGNMTEAGIARTRTWSTAYFFLTIGANSYCTNPDLSSKVQLPICVHTALNNPSMGYGRYFLWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPQ0</accession>
    <name>W4KPQ0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_27681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540267.1">
        <property type="nucleotide sequence ID" value="XM_009541972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPQ0"/>
    <dbReference type="GeneID" id="20669268"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_27681"/>
    <dbReference type="eggNOG" id="ENOG502SRIE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003921_3_3_1"/>
    <dbReference type="InParanoid" id="W4KPQ0"/>
    <dbReference type="OrthoDB" id="3252634at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW87798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="129" mass="15217" checksum="A39DB4ACEE31E990" modified="2014-03-19" version="1" fragment="single">MPARGDRTAPTFDPHQPRELRRYFSDLDFHFVRSAVVDEQERKKHACRFLDVDTCELWESLTTFTDATKTFKEFCEEVYRLYPGSEEERKWSVSDMDKLVGETSRVGILSLSELGDYHRRFLAITVFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KQU0</accession>
    <name>W4KQU0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_413728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541319.1">
        <property type="nucleotide sequence ID" value="XM_009543024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KQU0"/>
    <dbReference type="GeneID" id="20673129"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_413728"/>
    <dbReference type="HOGENOM" id="CLU_422136_0_0_1"/>
    <dbReference type="InParanoid" id="W4KQU0"/>
    <dbReference type="OrthoDB" id="10641969at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="649" mass="70855" checksum="150599157EC730BD" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>W4JM12</accession>
    <name>W4JM12_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane ATPase</fullName>
            <ecNumber evidence="10">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_108660</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="10"/>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553098.1">
        <property type="nucleotide sequence ID" value="XM_009554803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JM12"/>
    <dbReference type="FunCoup" id="W4JM12">
        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JM12"/>
    <dbReference type="GeneID" id="20666366"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_108660"/>
    <dbReference type="eggNOG" id="KOG0205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_6_0_1"/>
    <dbReference type="InParanoid" id="W4JM12"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000008">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="390"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="743"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="770"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="806"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="876"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="911"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="12">
        <location>
            <begin position="88"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="239"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="986"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="987"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1012"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1030"/>
            <end position="1045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW74592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1045" mass="114671" checksum="A3B83EDC70BD17CB" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMB9</accession>
    <name>W4JMB9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Esterase/lipase/thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_149096</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553168.1">
        <property type="nucleotide sequence ID" value="XM_009554873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JMB9"/>
    <dbReference type="GeneID" id="20667319"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_149096"/>
    <dbReference type="eggNOG" id="ENOG502S3TS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_15_1_1"/>
    <dbReference type="InParanoid" id="W4JMB9"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005945">
        <property type="entry name" value="Pro_imino_pep"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01250">
        <property type="entry name" value="pro_imino_pep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005539">
        <property type="entry name" value="Pept_S33_TRI_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="38"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW74673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="307" mass="34345" checksum="9D1C7569748BD795" modified="2014-03-19" version="1">MAQPKVVEGEADFVVPAAGKPCKTWYKVYGELHGSVCPLVALHGGPGVNHEYLTIFSDLTITHSIPLVVYDQIGTGFSTHLPEKMGDITFWTDQLFLDELDNLLSHLGIQDNYDILGHSWGGMLGSRHAVLQPKGLRRLVLASTPSDMKLWIESQNLLRSQLPQDIQDVLDKHEADGTTQSEEYQAAVGEFYARHLCILKPMPDEILAGFAWIQKDPTVYLTMNGPSEFYITGPLKDWTVTADAHKITVPTLVTNGQYDEAQDSVVTPFVQEIPNVKWVKFSESSHMSHFEEREKYMAEVGKFLVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMI2</accession>
    <name>W4JMI2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CHY-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_165087</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553173.1">
        <property type="nucleotide sequence ID" value="XM_009554878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JMI2"/>
    <dbReference type="STRING" id="747525.W4JMI2"/>
    <dbReference type="GeneID" id="20667963"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_165087"/>
    <dbReference type="eggNOG" id="KOG1940">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112589_0_0_1"/>
    <dbReference type="InParanoid" id="W4JMI2"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052604">
        <property type="entry name" value="Mito_Tim_assembly_helper"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082:SF2">
        <property type="entry name" value="CHY-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW74679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="169" mass="19391" checksum="C554776E861421AE" modified="2014-03-19" version="1">MCKHILNAQVSIRAPCCKRWFDCPECHAESESHPLARTMDMVFICKKCKKAFRKDMTVYEESDEYCPHCDNHYVRACSAYPVPLKFALGFARRRACDRSFSISTWQHSQRIKLIIFRALQVINAKSPQAMIGVEGEDARIDARLLKDDRVKGQSSKSLFVQDDSADRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMQ4</accession>
    <name>W4JMQ4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_127151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553244.1">
        <property type="nucleotide sequence ID" value="XM_009554949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JMQ4"/>
    <dbReference type="FunCoup" id="W4JMQ4">
        <property type="interactions" value="510"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JMQ4"/>
    <dbReference type="GeneID" id="20666976"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_127151"/>
    <dbReference type="eggNOG" id="KOG2919">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022731_3_1_1"/>
    <dbReference type="InParanoid" id="W4JMQ4"/>
    <dbReference type="OrthoDB" id="239865at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051150">
        <property type="entry name" value="SWT21/TCAB1_mRNA_Telomere"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211:SF0">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW74759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="44250" checksum="A52F923FD5F39895" modified="2014-03-19" version="1">MYRMSPEVENQYVWIPPSYTTSHGPSLSTTASLAPDSEFEQNFARSAKWCPDGSLALAQCENRTFEILDLCEPMTSLPSWPKHRVFPQAAPILDFIWYPRATPRDPASFCFVASVRESPVKLLDASTGRLRASYKIVDHRERQIAPHSMSFNGSADRYRLRSRLYCGFEDAIEVFDLNNPGEGTRLATTPSRKSRDGLKGIISALAFCPSYDPSSSMFAAGSLTPSSSVSPNIALFSEDTGSKPLAFNPMKPHVLYASFRRHGAIYGWDLRGDTSVPVQIFRPNGGGARPSTNQRIKFDVDLSGKWMSVGDQHGDISLFDLDKPEAEDAEGSDHALEADAVLRYTAHKDAVGSVAFHPLRPFLLSVSGSRHFDINSDINNQSSSSEEDEEEHQDSSSVTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNB8</accession>
    <name>W4JNB8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_164832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553431.1">
        <property type="nucleotide sequence ID" value="XM_009555136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNB8"/>
    <dbReference type="STRING" id="747525.W4JNB8"/>
    <dbReference type="GeneID" id="20667940"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_164832"/>
    <dbReference type="HOGENOM" id="CLU_1602950_0_0_1"/>
    <dbReference type="InParanoid" id="W4JNB8"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW74974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="19793" checksum="D1F16B3B56D7BFF3" modified="2014-03-19" version="1">MRTNKIQLPIISSDDLWTLQYIRINRLRFLFDRISLDASGFVTIYEITAFTSSRPARWSLLSWIAYWCVGWQTTLTKICQDIKAIFRNIFATLPYILRENKSEVNGYIEHVWPMHMEIVTCFRDTPMKDFLEEKFAEFFRETGKSLEQNLNKMKYHIDPPETAHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNL0</accession>
    <name>W4JNL0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_423634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW75069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553515.1">
        <property type="nucleotide sequence ID" value="XM_009555220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNL0"/>
    <dbReference type="GeneID" id="20673926"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_423634"/>
    <dbReference type="HOGENOM" id="CLU_2996745_0_0_1"/>
    <dbReference type="InParanoid" id="W4JNL0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="57" mass="6321" checksum="9190D5B9DC0FFCC3" modified="2014-03-19" version="1">MNIGKKISTRLSLNLRARARIRAERQGDRGAPRTRKMSKAKEQKALIEEAAAIVSAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPN4</accession>
    <name>W4JPN4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_108469</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553301.1">
        <property type="nucleotide sequence ID" value="XM_009555006.1"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JPN4"/>
    <dbReference type="GeneID" id="20666352"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_108469"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003572_2_0_1"/>
    <dbReference type="InParanoid" id="W4JPN4"/>
    <dbReference type="OrthoDB" id="6278596at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012880">
        <property type="entry name" value="Gryzun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021773">
        <property type="entry name" value="TPC11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374">
        <property type="entry name" value="FOIE GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11817">
        <property type="entry name" value="Foie-gras_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07919">
        <property type="entry name" value="Gryzun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 11" evidence="4">
        <location>
            <begin position="367"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Gryzun putative trafficking through Golgi" evidence="3">
        <location>
            <begin position="646"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="1256"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1225"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1225"/>
            <end position="1236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11817"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1594" mass="176286" checksum="2C8DCF53942E8628" modified="2014-03-19" version="1"> </sequence>
</entry>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
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                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
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                <person name="Yakovlev I."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="118" mass="12794" checksum="EC07C6386B703474" modified="2014-03-19" version="1">MGVLSNDSELAEGSEDAWTELKAPTVLIVYAIQSILSGVRSLIPSPTLNENLTQIITIMSSIVAVCHDNLPPVLAQQGNDILRELSDHTNKLSEVQAMRDTPTMQPSSITDTFESTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
    </protein>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
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                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
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                <person name="Lind M."/>
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                <person name="Lucas S."/>
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                <person name="Yakovlev I."/>
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            <dbReference type="PubMed" id="22463738"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="GeneID" id="20667920"/>
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            <end position="187"/>
        </location>
    </feature>
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            <end position="479"/>
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    </feature>
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    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQR7</accession>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
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                <person name="Velez H."/>
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                <person name="Wiebenga A."/>
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                <person name="Yakovlev I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
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    <comment type="subcellular location">
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KDA PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01922">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="3" id="KW-0733">Signal recognition particle</keyword>
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            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
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            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
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        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023135"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
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    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="31814" checksum="1FF0876888D2CFC6" modified="2014-03-19" version="1">MSRRAAIIEEFDDDVDLPLPSRPLPNTGTRGAILQEITDVDDASDDDEALDLVEPTAGPASPQGPSQGTPVVTDITPYKKWTCIYPIYIDAKQPYGTGVRRISREKSVWWPLSKDIADATNRLGLGTLHEVNKAHPRDWENPGRVRVQWKKEGRLMNPHIKTKKQLLEMISFQIQRIKPDYIPKPPFSYPTPATPPTSASAAKSSKPKSISSKSSASVPKSKDPAPPKQTSRPLPNPPEPLPSPASRMSVYSPALPSGVLVDTVKAGMNAEGAAPGVAGGGAAGKGKRKVVRVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRH8</accession>
    <name>W4JRH8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_106673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552292.1">
        <property type="nucleotide sequence ID" value="XM_009553997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRH8"/>
    <dbReference type="GeneID" id="20666182"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_106673"/>
    <dbReference type="HOGENOM" id="CLU_2469376_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRH8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="88" mass="9398" checksum="045960BB45AC7B94" modified="2014-03-19" version="1">MNAVKLLPDCLVIGYGGVDGRQWGQIAGSGTGRLLALYICMDGWEHLPCTQHALPSVTLLPLPLVTHIPMGVIRASVPSRPPVDRRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRX6</accession>
    <name>W4JRX6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_218303</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551227.1">
        <property type="nucleotide sequence ID" value="XM_009552932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRX6"/>
    <dbReference type="STRING" id="747525.W4JRX6"/>
    <dbReference type="GeneID" id="20668646"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_218303"/>
    <dbReference type="eggNOG" id="ENOG502SDAT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_19_3_1"/>
    <dbReference type="InParanoid" id="W4JRX6"/>
    <dbReference type="OrthoDB" id="1878542at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="3"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW76302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="454" mass="50159" checksum="DCFBF22689B7F161" modified="2014-03-19" version="1" fragment="single">LQLDIVIVGAGLAGLASAYALAASGHRVRVFEKSKVVSTVPGGIRIPPNGTKILDDWGLHDELVQKSAQVKSNSFIDMAIGELIGHTEWAHEMFKDSGGEFRCMRHEDLTQMLYRHAVAAGALFHFGARVNGVSPAPDIDSSPSTPSIPRQSQLHPQPSIILSDGQEILADLVIGADGPRSLIRLVVDEDAGDVREIETGTTLYTGVLDGKTMMGNEHLKKLINAHFPVWMGDGSMAVAFPIGRDNSYAMHVYSPEEWPEGALDWELVASSNLRCDHLEPRVQSFLKNAKHLTRARWIERPPAEDWVDASERIILIGEAAHPLAPCEMHAGSGSLESAFVLSTLLSHLHSRSQLPSLLYAYQDLRSSRLARLHQIEMDNHMYLGLRAGEGKEERDTTMRAARLAAKNGADANAEADDDGELDRQWGEMCEIWGYDARDDAEDWWVRWGLLRERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4JT73</accession>
    <name>W4JT73_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_446573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551634.1">
        <property type="nucleotide sequence ID" value="XM_009553339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JT73"/>
    <dbReference type="GeneID" id="20675695"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_446573"/>
    <dbReference type="eggNOG" id="ENOG502S5EX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007544_0_0_1"/>
    <dbReference type="InParanoid" id="W4JT73"/>
    <dbReference type="OrthoDB" id="3358861at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036286">
        <property type="term" value="C:eisosome filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF1">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004843809" description="DH domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        <location>
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        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
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            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
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                <person name="Velez H."/>
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                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">TC 32-1</strain>
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        </location>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01753"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW76096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="114" mass="12765" checksum="274BDE34B9EA49A7" modified="2014-03-19" version="1">MASSQSTPPKECAACSKDASDQLLTCPRCQNESISYCSQECQEADSQHSWDCRLPVVQGIQILCDGERHDPPFNPVEITPTHQIYEYGDVCPVSEVIDLPIVMFRHSTEHPLNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
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                <person name="Bouzid O."/>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009553164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTZ8"/>
    <dbReference type="GeneID" id="20671479"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_329249"/>
    <dbReference type="HOGENOM" id="CLU_050560_0_0_1"/>
    <dbReference type="InParanoid" id="W4JTZ8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="185"/>
        </location>
    </feature>
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            <begin position="313"/>
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        </location>
    </feature>
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            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4JU00</accession>
    <name>W4JU00_HETIT</name>
    <protein>
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    </protein>
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    </gene>
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        <lineage>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
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                <person name="Hietala A."/>
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                <person name="James T.Y."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Lunden K."/>
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                <person name="Wiebenga A."/>
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                <person name="Yakovlev I."/>
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                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
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    </dbReference>
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    <dbReference type="FunCoup" id="W4JU00">
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    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_156676"/>
    <dbReference type="eggNOG" id="KOG2262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004965_1_1_1"/>
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    <dbReference type="OrthoDB" id="9986677at2759"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
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    </dbReference>
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        <property type="entry name" value="OPT_sfam"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="394"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="474"/>
        </location>
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        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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        </location>
    </feature>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW76341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="778" mass="87091" checksum="1065E0CDD0DE46AF" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4JU51</accession>
    <name>W4JU51_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_327342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="39"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="305" mass="33631" checksum="A475F52E7253AD43" modified="2014-03-19" version="1">MTTLCSESYVFDGRPAYPLLVPAKRYWHPSLSQEDGLTLILAHGTGFHKEHWEPFLDDLFGLLGTAASIGGPRLRVREAWAIDAPNHGAGALLNEAVLRFGYEPVFAWDEYALAIHRFLAGHGSGIPVDFARRRLVAVGHSFGAIALVLTRTYTPAPRFEAAVLVEPMLITEATAADATFAGNFLEQNAAKRRDVWPSREAARELFAARSFKDWDPRVLDLHVKHGLRDLPTLTYPDKQGVTLTCTKIQEAATYRDSHGRFAALRYLATFCADVPTHAVFGAIADYVCVSPSSPLFSRARAIRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUG4</accession>
    <name>W4JUG4_HETIT</name>
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        <submittedName>
            <fullName evidence="10">ACE transcription factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ace1</name>
        <name evidence="10" type="ORF">HETIRDRAFT_147959</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009552437.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="W4JUG4">
        <property type="interactions" value="173"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JUG4"/>
    <dbReference type="GeneID" id="20667244"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_147959"/>
    <dbReference type="eggNOG" id="ENOG502S7CA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033839_0_0_1"/>
    <dbReference type="InParanoid" id="W4JUG4"/>
    <dbReference type="OrthoDB" id="5600085at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.430.10:FF:000001">
        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01119">
        <property type="entry name" value="COPPER_FIST_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="155"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="163"/>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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            <end position="199"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW77193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="599" mass="63845" checksum="9C9679A3AAF7F392" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUW3</accession>
    <name>W4JUW3_HETIT</name>
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        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">HETIRDRAFT_105530</name>
    </gene>
    <organism evidence="1 2">
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUW3"/>
    <dbReference type="GeneID" id="20666074"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_105530"/>
    <dbReference type="HOGENOM" id="CLU_1825532_0_0_1"/>
    <dbReference type="InParanoid" id="W4JUW3"/>
    <dbReference type="Proteomes" id="UP000030671">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW77317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="141" mass="15219" checksum="2A143A0763F08D4E" modified="2014-03-19" version="1">MDSCPEYFANTSHLAGTILLSCIPARTEWGRIRGQTASTSWPSQMPMRDCLSDGYNFGAALSQLAYNSAYLYEPTECGQCRACPVAIGLPMYTSADYDPSPTRAVGDVIGNPTGSSIPVMADFDFSDLIANNPLMSCMIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
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    <name>W4JVH4_HETIT</name>
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        <recommendedName>
            <fullName evidence="1">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">HETIRDRAFT_173803</name>
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    <organism evidence="2 3">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
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                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JVH4"/>
    <dbReference type="GeneID" id="20668468"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_173803"/>
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    <dbReference type="InParanoid" id="W4JVH4"/>
    <dbReference type="OrthoDB" id="2638860at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6533" evidence="1">
        <location>
            <begin position="3"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="68" mass="7840" checksum="0F98E6AD1E3F9B4A" modified="2014-03-19" version="1">MMILIQDWLVLFGEEVDLVWNSQWSIPKLLYIINRYAPFVDVTLDLYHSLSKSISPEVPSPSEVQCDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JW69</accession>
    <name>W4JW69_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_107454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549825.1">
        <property type="nucleotide sequence ID" value="XM_009551530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JW69"/>
    <dbReference type="GeneID" id="20666246"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_107454"/>
    <dbReference type="HOGENOM" id="CLU_1283405_0_0_1"/>
    <dbReference type="InParanoid" id="W4JW69"/>
    <dbReference type="OrthoDB" id="3222020at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="215" mass="24382" checksum="CAE64EE85C4ED213" modified="2014-03-19" version="1">MPLVFLWLGRVHILVNRAREEDLGDDDSDALSTVVSMRMNVSAQIRCFCGGIFNSWYESQNLNNIYRRLLTAINEGDEDRDYVEDDDDDSSNDEGAERQQKLIVKESKPDRQPKLKGDVDRKMQQLWQRMNGLDDRLGNIENLLKALVTAKNIGPLSSSTSTVQPISRQVAQNDAPVDCEPPTSSRGSNDQDTDKDNEAVRGEYFGETREYYGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4JX31</accession>
    <name>W4JX31_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_441917</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551119.1">
        <property type="nucleotide sequence ID" value="XM_009552824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JX31"/>
    <dbReference type="GeneID" id="20675396"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_441917"/>
    <dbReference type="eggNOG" id="ENOG502STUW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_551016_0_0_1"/>
    <dbReference type="InParanoid" id="W4JX31"/>
    <dbReference type="OrthoDB" id="3006100at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845025" description="F-box domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="7"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW77640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="475" mass="52086" checksum="7C79481B28A4C833" modified="2014-03-19" version="1">MSPSSPPLAVSDLPLELILAVFYWCTLASPDAPLTISSVCRRWLQLARSSPELWTRLDLHFHSLPHNPDPAQGKHSLSHAVQKATAWFDRSGIASLDVQITIRNPAARPCRRSPSPSPSPSPSPSSPITIPSDSPLASLFQTHIHRIRTLVVHAPSEAGIQPLIRPFHFPEPAPADDSPRSSLLELELEATDDSPPAHPPLTDSAVATLPFVTPKPISVHLTNLAVPSTWLNLESLASLTVTHPILAPPLSLTHIFALLEKSPALQYFSLHSRIFEAPAASSLSPIRTLSLPHLHSLHLTLNNTIDVLLALRTPTLSTLSITDLDGRAPWTGRALKAFLTSRPPLKHVKFERLLGIEHGTWEWCLARLPLLEGASLAYCERGEYIVAALARRPGDKPEPQSLARARAEPTELCPGLRHLSLVQCPGVYDSILPWFRTIRPQLRMDVVNCSDAEDEEGGWEGWDGLASRGWGVHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXC6</accession>
    <name>W4JXC6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CCAAT-binding factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_388307</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550208.1">
        <property type="nucleotide sequence ID" value="XM_009551913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXC6"/>
    <dbReference type="FunCoup" id="W4JXC6">
        <property type="interactions" value="454"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JXC6"/>
    <dbReference type="GeneID" id="20672362"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_388307"/>
    <dbReference type="eggNOG" id="KOG2154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015945_1_0_1"/>
    <dbReference type="InParanoid" id="W4JXC6"/>
    <dbReference type="OrthoDB" id="10263185at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027193">
        <property type="entry name" value="Noc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455:SF0">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="6">
        <location>
            <begin position="380"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="259"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW78217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="597" mass="67112" checksum="604C13E1FFC85214" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXK1</accession>
    <name>W4JXK1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_421040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550264.1">
        <property type="nucleotide sequence ID" value="XM_009551969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXK1"/>
    <dbReference type="GeneID" id="20673695"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_421040"/>
    <dbReference type="HOGENOM" id="CLU_050560_0_0_1"/>
    <dbReference type="InParanoid" id="W4JXK1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="479" mass="52711" checksum="ADACE2B4A250E469" modified="2014-03-19" version="1">MLLHDDHDASSPSRNSSPDVVLMVANPDVERVERGTSPHRPDAGRIDRGTSPQQPGPTGDLLTPQLNNFSDDDAEDYAKFKERERTRRPSPERASRDAPRHENPDDRNQSSLGQLPVGVPPPSEGTPNSGVAGPSGFRARTAAQLPSHGEAEPIPVLSETAPPPVPTSGPIPSSMGGPTPRTDPHAGELERHADALLQRNTISAVIQMATAMALQRLANFSAGQPGNEHSDVPRRLASASLQIRALALQTDPDTASWYAHNDGRPRALLIHPDEFSQYVNRELLPALLFGGELGNVQPSRTDPFRVVTWNVPRPGEHPTPVPNPRRVPRTVVERPPSRQREVPTAHSHTATPPSHRIRGFPLSQGNTDEEEPPVYRRNEGRRSRGSQATLGRGTTAGRSVRHQPRSPPPSARFRTNEREDNRSSRRTRRTDSEARRNSSWTRSELDAWDALDDPGNYDEADPYYRPDEGGGDYQGPFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXK4</accession>
    <name>W4JXK4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_454281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXK4"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_454281"/>
    <dbReference type="HOGENOM" id="CLU_1835420_0_0_1"/>
    <dbReference type="InParanoid" id="W4JXK4"/>
    <dbReference type="OrthoDB" id="10381617at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="140" mass="15705" checksum="9CDA87BEEFA8560D" modified="2014-03-19" version="1">MTTGRINQVTTFRTAQAATGTRASTFPAGVRQRGFGIAPCVFWIRRSREVAFRRKGVQATRRPTMETPCSPISHILDELSLSKRTRITVLDEDYQQPAAPGRHAQSRRIPEWLFATGLAIGKQSTPFYIADTHHKRAVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JY03</accession>
    <name>W4JY03_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fucose-specific lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_453889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549790.1">
        <property type="nucleotide sequence ID" value="XM_009551495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JY03"/>
    <dbReference type="GeneID" id="20676445"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_453889"/>
    <dbReference type="eggNOG" id="ENOG502RQSA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091065_0_0_1"/>
    <dbReference type="InParanoid" id="W4JY03"/>
    <dbReference type="OrthoDB" id="5367135at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW77756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="31612" checksum="521F1B634EFF7390" modified="2014-03-19" version="1">MAQFQDLTRRLLAAGGAMDPEGKSMFLLYTDRSSLVSKHWTGETFGDQDVVATSIRANSTASYLFSPNSRRIICISAASAIRSLTFNEDEEEWVDDAIPRHDVHPEGKLATAFGADHRAYVFFQNPAGQLVQLDDRWNPTILPADPVVGSPLATTVGEKIHLFYLSTKDNCIHYVVQGDEGSWSDKVVSKAALEGKVKRFSVGKNEETGVFEVYVLTEKNGLLQIVGDEDGKANASAEKTVLGKVDENEQKRAMRYGRPDNSSCPGEALTKVQFQSNTSSTLHHVVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0H1</accession>
    <name>W4K0H1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin protein disulfide isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TRX7_PDI</name>
        <name evidence="4" type="ORF">HETIRDRAFT_64006</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548799.1">
        <property type="nucleotide sequence ID" value="XM_009550504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0H1"/>
    <dbReference type="FunCoup" id="W4K0H1">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K0H1"/>
    <dbReference type="GeneID" id="20678662"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_64006"/>
    <dbReference type="eggNOG" id="KOG0191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048905_0_0_1"/>
    <dbReference type="InParanoid" id="W4K0H1"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844220" evidence="2">
        <location>
            <begin position="20"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="16"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW78631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="428" mass="46976" checksum="D57CED5E5D029CA8" modified="2014-03-19" version="1">MLPQLLALTLAIAPAAVSAGLFPSNSLVKHLDAKGFRQALKENRTSVIAFVAPWCGHCQRMAPELSKAALGLYPLIPTYAVDCDDAKNRQVCAEQGVKGFPTVKLFPRGKDVKPITFEGGERTASAFYYWATRRVPNKNKKLYHLEDIEPWVTKNIEKNRVLLLNKGKTVPLLWQVLGNKYKDQLEFGSHRDRKGKTGKALGVGMGGKKESRVLVYPAGSTSPVVFEGILKHDSLSKFFDSVIDGSADLKVVNAQAKDEEFALTEEELEIERQQEAQRIALAHGGFTEMIDFEEAVKKYGADFHDAHGYGGMMGEMPKKKDAAAAAEEGTAKQRKEEDPIHKILKHQQEKEKEKERAQRETTPKTGDGGQIVFQAKTETGHRPTSTAQKPKATESAGDVPSESAETPAPPAESTSASNEEAGHVKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0K9</accession>
    <name>W4K0K9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pantoate--beta-alanine ligase</fullName>
            <ecNumber evidence="3">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pantoate-activating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pantothenate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_240083</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(R)-pantoate + beta-alanine + ATP = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="3"/>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548984.1">
        <property type="nucleotide sequence ID" value="XM_009550689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0K9"/>
    <dbReference type="FunCoup" id="W4K0K9">
        <property type="interactions" value="319"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K0K9"/>
    <dbReference type="GeneID" id="20668841"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_240083"/>
    <dbReference type="eggNOG" id="KOG3042">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047148_1_0_1"/>
    <dbReference type="InParanoid" id="W4K0K9"/>
    <dbReference type="OrthoDB" id="2020436at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000013">
        <property type="entry name" value="Pantothenate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="entry name" value="Pantoate-beta-alanine ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299">
        <property type="entry name" value="CYTIDYLATE KINASE/PANTOATE-BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PANTOATE--BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW78666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="339" mass="37042" checksum="6EC7BF8029014898" modified="2014-03-19" version="1" fragment="single">ATSAAVDASAIPIFATVREYREWRQKAFDEKKSVGFIPTMGALHDGHLSLVKRSLAENDLTVLSIFVNPAQFAPHEDLATYPRTLPHDLKLLSALSHPVPNSSRPRAPSAVFVPSVPEMYPSGISQDVENQTGTFVEVKGYGEQMEGQSRPTFFRGVATVVAKLFNIIQPTNAYFGQKDIQQALLLRRLVTDLHMSYPSPSRLHIVPTARDPTTGLALSSRNAYLTPAEREKAPALYAALQAGARAWGAGESKADCVQRAIEVFSRAGSLLPGDKQGNARATKEKVTMKVDYIEFNDPSSFSVLPEDESQTKRGRSPVILSGAVWIGRTRLIDNLILGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4K100</accession>
    <name>W4K100_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_434987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548067.1">
        <property type="nucleotide sequence ID" value="XM_009549772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K100"/>
    <dbReference type="GeneID" id="20674793"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_434987"/>
    <dbReference type="HOGENOM" id="CLU_1704448_0_0_1"/>
    <dbReference type="InParanoid" id="W4K100"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="154" mass="16492" checksum="33CD0376668DD70D" modified="2014-03-19" version="1">MVGQLGCRMSAEAGPLYHRMAIPWSASEVAAPSGGGISSTVCRDKLRRFDGEGGRGRVSGMNGAGVDVHRGSQQVGGWWRRQSDRWITSVLPGSCRGMLEFSTPSTLSPAISCDTPQIHKIIVILPEERVILMAQACGTILANSTKFCTITESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1I1</accession>
    <name>W4K1I1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_386078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548151.1">
        <property type="nucleotide sequence ID" value="XM_009549856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1I1"/>
    <dbReference type="GeneID" id="20672263"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_386078"/>
    <dbReference type="HOGENOM" id="CLU_1235168_0_0_1"/>
    <dbReference type="InParanoid" id="W4K1I1"/>
    <dbReference type="OrthoDB" id="2752889at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="224" mass="25504" checksum="E076D62B7817E8D5" modified="2014-03-19" version="1">MRNIPIEVLDGNVIEYVETVCAVVSEVEYLNLAGSDRIYGFDDDSGDSGMRTSPRQTPPLRPQSRMSTRPREQTYTVPFAFNSLEECLHTLFFPIWTAMVGGALLMYPESLPSLVFEKGYAPVPTSPLDRIAYYGNYAVPHVWIFIGCVVGTALVDPRVFGTLVLLVTLRTMHVWRGYANNRAERLLDERRQSEEIKQWEMDMWCVYLVFAGKEEQFSSLLSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2Q9</accession>
    <name>W4K2Q9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_410548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548544.1">
        <property type="nucleotide sequence ID" value="XM_009550249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2Q9"/>
    <dbReference type="GeneID" id="20672876"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_410548"/>
    <dbReference type="HOGENOM" id="CLU_1170772_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2Q9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="237" mass="24685" checksum="F8E0F6238CA2C403" modified="2014-03-19" version="1">MIMRTASVLTTPAMTPTFLVLARDESLVRGALLPVALPMSAEVGLGLGVRLLSSKVELGTTLKMLPTDVADELVAETVADGVSVMESDEATDGWTVESGAGLSVTDGGPAVVVGDENICANGEGAEVENAENAEDGDRDGNGDEVVAELEVVEKVVEAGGSEVIVDRLLESVVRTVDEVSDKLEKSVKEAEEADEPKENEEADEATEVDGEAEKEAEVSTEVEDDGADVVADVAERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2U4</accession>
    <name>W4K2U4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_453802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549609.1">
        <property type="nucleotide sequence ID" value="XM_009551314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2U4"/>
    <dbReference type="STRING" id="747525.W4K2U4"/>
    <dbReference type="GeneID" id="20676427"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_453802"/>
    <dbReference type="HOGENOM" id="CLU_2097187_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2U4"/>
    <dbReference type="OrthoDB" id="2186602at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="116" mass="12511" checksum="C302F6BD39791523" modified="2014-03-19" version="1">MDRGEGTTTLPGTLPPDAFFSKHAHSTLRTAAHASHERTLSSASGYVHHHVAGAAKSTTSPAKRRYVADAHGLEIVKKIRQGEVELRDRTIVLCDIKANRLVMSAAYQDSGPPIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4K361</accession>
    <name>W4K361_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dipeptidase</fullName>
            <ecNumber evidence="1">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_35489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="1"/>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547911.1">
        <property type="nucleotide sequence ID" value="XM_009549616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K361"/>
    <dbReference type="STRING" id="747525.W4K361"/>
    <dbReference type="GeneID" id="20671793"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_35489"/>
    <dbReference type="eggNOG" id="KOG4127">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031404_4_0_1"/>
    <dbReference type="InParanoid" id="W4K361"/>
    <dbReference type="OrthoDB" id="445695at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000180">
        <property type="entry name" value="Dipep_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00869">
        <property type="entry name" value="RENAL_DIPEPTIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW79770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="445" mass="48476" checksum="B7C5FFF95986BB3C" modified="2014-03-19" version="1">MSATPPSESAPLLPDVERAKPEPTKRIRAVIHAALSVIFVLTLVLVLFFLDDGISGSWLSGQLPKDPILAAQEVLKVAPVIDGHIDLPWLVRAAYANNATAIDLESRMPGHVDIQRLKEGHVGGFFWSVYTSCPRDAGYDPDGDFVNSTWSVRDTLEQIDVARLLIDKYPDVFELTLTAAEVRSAIGRGKIASLLGVEGAHQLGNSIGVLRQYYSLGVRYMTLTHTCHNAFADSCGLFDGIEPLHGGLSTLGRALVPEMNRLGMLVDISHTSDATALEAISVSRAPVMWSHSSARTLRDIPRNVPDSVLGKIGDESEGKKDGIIMVNFYPAFVHDSGEADVSVIADHVEHIANVTGKKHVGFGSDYDGINTVPKGLEDVSKYPVLVAELYRRGWSKLELSGLTGGNMLRVLEGAERVKEEMRREGVQPAADLYDKRPDLPIKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3M7</accession>
    <name>W4K3M7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_440315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547169.1">
        <property type="nucleotide sequence ID" value="XM_009548874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3M7"/>
    <dbReference type="STRING" id="747525.W4K3M7"/>
    <dbReference type="GeneID" id="20675254"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_440315"/>
    <dbReference type="eggNOG" id="KOG2401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_778579_0_0_1"/>
    <dbReference type="InParanoid" id="W4K3M7"/>
    <dbReference type="OrthoDB" id="3231855at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053020">
        <property type="entry name" value="Smr_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417:SF1">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="271"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW80412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="356" mass="38940" checksum="1D836655C6EC57F9" modified="2014-03-19" version="1">MHIAPPASVYMESSYSRLSPDDQEATLTISQRAPVSNGFAIPADTPFQPSSALPEAPIVLSVPSSRTTPSASRRDVLSAAVKEVPPAHIEVMEHAASKAQSADMAPANAPAQLQIVPSAKRPKEYAYRKKRVRSRARASMHPQSADRGTGSPVELKRPTDIAPATKNSRRKRSIGMKCIAPAAEVGTETTPADTDKARRTFKAMQRAPAQRMCKRMREAQAKLKHCGRDVRKKGKLLDLIEECEKEMMRLNAIAADLIFKEFNKDRRANNVDLHGLRVSEAIKYANEAVTKARSRGDLTLSLIVGRGLHTEDKVPKLKPAIMQFLENLGLAVAEQPGNAGRLIIQLGGWSDNEDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4J4</accession>
    <name>W4K4J4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_321174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547463.1">
        <property type="nucleotide sequence ID" value="XM_009549168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4J4"/>
    <dbReference type="GeneID" id="20670727"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_321174"/>
    <dbReference type="HOGENOM" id="CLU_1129177_0_0_1"/>
    <dbReference type="InParanoid" id="W4K4J4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="246" mass="26702" checksum="475CEB02D552FAA2" modified="2014-03-19" version="1">MDDVHLEVMPPLETDYPAEASATHDRGESMHHGHHEHHGGYHNQGKRAASVHRASAHPEVPLSMPYNPHAGSWDITPERLQHHSPQQQQPRQLYIGPSLTRPKGASLARQWAADDGATMPPPSSWSVPAHGSAEIPPARPQPAAYYASQPETIPAGHYRRMVPPTKMEVEGAGAPYPPSAAAAAAMGGSGVVEGYGGVLHGEQTGSRGYSWEEVQAYWAYSHQDTGNPRRSEHDAVNQGYIRVRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4N7</accession>
    <name>W4K4N7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="12">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="12">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ALA1</name>
        <name evidence="14" type="ORF">HETIRDRAFT_476425</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="12"/>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547440.1">
        <property type="nucleotide sequence ID" value="XM_009549145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4N7"/>
    <dbReference type="FunCoup" id="W4K4N7">
        <property type="interactions" value="680"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K4N7"/>
    <dbReference type="GeneID" id="20677684"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_476425"/>
    <dbReference type="eggNOG" id="KOG0188">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_5_0_1"/>
    <dbReference type="InParanoid" id="W4K4N7"/>
    <dbReference type="OrthoDB" id="2423964at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070143">
        <property type="term" value="P:mitochondrial alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.130:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.40:FF:000001">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059090">
        <property type="entry name" value="ALA1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26023">
        <property type="entry name" value="ALA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
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    </dbReference>
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        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
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    <keyword evidence="3 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
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        <location>
            <begin position="13"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="607"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
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    <feature type="binding site" evidence="12">
        <location>
            <position position="611"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
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    <feature type="binding site" evidence="12">
        <location>
            <position position="726"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
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        </ligand>
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        <location>
            <position position="730"/>
        </location>
        <ligand>
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        </ligand>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW80724.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="959" mass="106991" checksum="93CE6D5463AFBCC0" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4Q1</accession>
    <name>W4K4Q1_HETIT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">HETIRDRAFT_101884</name>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <location>
            <begin position="83"/>
            <end position="119"/>
        </location>
    </feature>
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        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="119" mass="13301" checksum="9035A8303AB7F1C9" modified="2014-03-19" version="1">MRNTAIEKVLNRKMRPRYLGPLLVISRNRGGAYILAELDGSVFDWPIAAFHVIPYFARRSLKLTKLEALLDISQERLWAIEESRSSNDDAEADDANEEDTNTSSVRSAKDDDAASGTSD</sequence>
</entry>
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            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
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        <name evidence="3" type="ORF">HETIRDRAFT_452290</name>
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        <lineage>
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            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_452290"/>
    <dbReference type="eggNOG" id="ENOG502SRIE">
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    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="76"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW80784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="215" mass="24461" checksum="CDA7E39BD015FEFB" modified="2014-03-19" version="1">MTAFIAKRFWWPHMRQDISWFVRTCHLCQIRQTRNILIPLTVALPAPLFAKMYMDTMHMPTTGSFKYLVQALADWIFEDILCRWGTLVEIISDNGPAFVKALDQLAKKYHIRHIHISGYNSRANGIAERPHFDVRQALFKAVDGDQAKWNSTGTHPLLPLDIAKATYHLPPPTTTLSTTDLIARRAIALQKCRSDLAHLCSSVVDAHVQAAIQFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4Y5</accession>
    <name>W4K4Y5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_477676</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548637.1">
        <property type="nucleotide sequence ID" value="XM_009550342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4Y5"/>
    <dbReference type="GeneID" id="20677772"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_477676"/>
    <dbReference type="HOGENOM" id="CLU_1036456_0_0_1"/>
    <dbReference type="InParanoid" id="W4K4Y5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="269" mass="29183" checksum="37551900299071D2" modified="2014-03-19" version="1" fragment="single">MKPKKDGEHYNSSLKSIENPSVVPGSEKERRKAQTTWKKVTVSEDVEVIEIISSDESGDESSNTKLPSSQLDGSHANLLKRPDDEKTEDEAEASEREVSIPRKTGSAATGKKAQVSRKKQSHRIIYSSESSDDDNLSPASKPASTEVIEISSGSDSGDESSDDDVTIPPSPVSLLRSKKLRESIHDESYESDDGTILTLDDPKSARKPVRLLPPNGILAGPNRLSQMPSTPVKLRATDPSTPHTLRADSTPHPFPALPYSPSSWPLVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5H2</accession>
    <name>W4K5H2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_427834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547687.1">
        <property type="nucleotide sequence ID" value="XM_009549392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5H2"/>
    <dbReference type="GeneID" id="20674232"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_427834"/>
    <dbReference type="eggNOG" id="ENOG502S1BV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068116_1_1_1"/>
    <dbReference type="InParanoid" id="W4K5H2"/>
    <dbReference type="OrthoDB" id="2140489at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36986">
        <property type="entry name" value="UPF0643 PROTEIN PB2B2.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36986:SF1">
        <property type="entry name" value="UPF0643 PROTEIN PB2B2.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="273" mass="29667" checksum="3C57D82BB5D1317A" modified="2014-03-19" version="1">MHPSLSAFRASGSSSLRDPSGATSLADPAFDAVEPASGTHSPASILSDLSDTDAPHDPHALPSFSSTTLTRPSEPILYLPPLISSLPYTYPKHLPAATPSAGKSPLATETRLPNIDPASLSLHKALHNFGPITDKYAEVSYADAFNWDELELPEDEEREWYCVAFRSIRKPGSEAGPLYEADKLAHEEAIRNGGLIMYWYGIPDPATGRNLATCIWQSRAHALAANGRPHHIRAMRLAAASYDTYDLERHTLRKARGSRRVSVEPFTGGAVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5Z4</accession>
    <name>W4K5Z4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_452601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547888.1">
        <property type="nucleotide sequence ID" value="XM_009549593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5Z4"/>
    <dbReference type="GeneID" id="20676275"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_452601"/>
    <dbReference type="HOGENOM" id="CLU_1518056_0_0_1"/>
    <dbReference type="InParanoid" id="W4K5Z4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="177" mass="19017" checksum="D185D3FEB62D47C3" modified="2014-03-19" version="1">MEEDSRKNVPIARIPAIKRPDPLLLLLLAVSMHHGARLLLSLPFPHASHFSQARPQERSTRAVSAVEDRSAGAWDVQEQGRVCREAGAKRGSIPREYPRRTSLLSPQRVFPPPTFLIVVVVVVDIAVVDARTVAMLGPSSGSVSVWASVGQDASATVIVGGTGKRDGGERGRRCGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6H6</accession>
    <name>W4K6H6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_123143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547391.1">
        <property type="nucleotide sequence ID" value="XM_009549096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6H6"/>
    <dbReference type="STRING" id="747525.W4K6H6"/>
    <dbReference type="GeneID" id="20666809"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_123143"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_704058_0_0_1"/>
    <dbReference type="InParanoid" id="W4K6H6"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF30">
        <property type="entry name" value="PHOSPHORYLASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="94"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW80671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="365" mass="40969" checksum="B5ECC14CF9F59831" modified="2014-03-19" version="1">MRPTVHVKRLTLTSKKNWWMVELDEEEEKLKPSAHSFSSLDDTVYNDYVPHTEPPPHPPPSPPASPPPYNPPRHPGSIFSFPIPATYSAPPNPTGSLAPIATGSASELFKCIVKKPEIVQLEVNGEMESNAYDIAAQFLAELRVYTTVSKHRNIPAFLGCLESVGMVLEFVEGPTLYDFIREQPEPAPALKKDLHNQLLDGLTHLHAFGLSHGDLSMLNVHVMPNGTVKVLDFGRSVSAESIISSPDDGPVDPFAHLTQTPSFRGAPQVRVEQIHPGTRPFSAPEILRGECQDARLADAYSFGMVLVCIERWTLVDVKPWDQRRDLLPFDIFDGCVLFESRIREYLKKWDQRRRLFKEDTVMITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6L6</accession>
    <name>W4K6L6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Altered inheritance of mitochondria protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">AIM41</name>
        <name evidence="2" type="ORF">HETIRDRAFT_418679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM41 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547422.1">
        <property type="nucleotide sequence ID" value="XM_009549127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6L6"/>
    <dbReference type="GeneID" id="20673499"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_418679"/>
    <dbReference type="eggNOG" id="ENOG502RSF8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079430_1_0_1"/>
    <dbReference type="InParanoid" id="W4K6L6"/>
    <dbReference type="OrthoDB" id="538640at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="entry name" value="Uncharacterised protein YqeY/AIM41 PF09424, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="184" mass="20431" checksum="681706A4C0D80305" modified="2014-03-19" version="1">MYRLLSNISGPALRCTKQLQWRQYTASAIETDIRTRLLTGLKTSMKSKDTFASTTIRSILSEVYSADKASPESKIPSATIVSIIRKATNRRIDSAVQFTQAQRPDLAEKEQHEADFLSSFLPPLLPESDIDHILGEVISEQTADAQSHPGKLLGKVVKAFYSKVDKSNVDPTLVKRRAEALLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7A6</accession>
    <name>W4K7A6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_440014</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546305.1">
        <property type="nucleotide sequence ID" value="XM_009548010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7A6"/>
    <dbReference type="FunCoup" id="W4K7A6">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="GeneID" id="20675218"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_440014"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_2_1"/>
    <dbReference type="InParanoid" id="W4K7A6"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF3">
        <property type="entry name" value="AMINO-ACID PERMEASE PB1C11.02-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="562"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="76"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="173"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="266"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW81683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="657" mass="72609" checksum="17B2F2ED84DD628F" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7C9</accession>
    <name>W4K7C9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_237178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546349.1">
        <property type="nucleotide sequence ID" value="XM_009548054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7C9"/>
    <dbReference type="FunCoup" id="W4K7C9">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K7C9"/>
    <dbReference type="GeneID" id="20668770"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_237178"/>
    <dbReference type="eggNOG" id="ENOG502QPU6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003477_2_3_1"/>
    <dbReference type="InParanoid" id="W4K7C9"/>
    <dbReference type="OrthoDB" id="10249045at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000964">
        <property type="term" value="P:mitochondrial RNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013943">
        <property type="entry name" value="Pet127"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION SYSTEM COMPONENT PET127-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014:SF0">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION SYSTEM COMPONENT PET127-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08634">
        <property type="entry name" value="Pet127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="443" mass="50022" checksum="2C7A857AFC09B50F" modified="2014-03-19" version="1" fragment="single">DLEPPSPQQPIAQLAHGLDRVLFNPGVSWLQDPRSNVYNYTTWLENVPSVKDFAFERLGGFISSSRDQDLWSLARSEKRTFAGSTSSLSGLLSHIYFLISGDKRVNTTSLSRHFQYEPTNFTPGQRMPASVVLKHSDGVYAIDSLSLIPGSSEKNVLTWMGTVLEKFLTMPKEQFSRLLRSSPDPTEEPESKREAYRYSKSDKFVMRSQLDCYDSRLPGTGVFDIKTRAAVPIRLDLMNYEENSGYIIRTLQGPLESFEKEYYDLIRSAFLKYSFQARIGNMDGVLVAYHNTARIFGFQYVPLSEMDSCIFGSEGRGDRVFEKCVQMMEAIMTEAVHQFPDQSIRCVTEKKEGSDVLQVFLEPADWNEETQGPTPIVQLDVTVVNYAGDTEVRGSTAVARSDLPWTILYSISIPSLSLREIRGNLSEVISRQFFAYNLPSGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7W3</accession>
    <name>W4K7W3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_317563</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546432.1">
        <property type="nucleotide sequence ID" value="XM_009548137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7W3"/>
    <dbReference type="FunCoup" id="W4K7W3">
        <property type="interactions" value="444"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K7W3"/>
    <dbReference type="GeneID" id="20670429"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_317563"/>
    <dbReference type="eggNOG" id="KOG1658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045277_12_1_1"/>
    <dbReference type="InParanoid" id="W4K7W3"/>
    <dbReference type="OrthoDB" id="636685at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23645">
        <property type="entry name" value="HFD_Dpb3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF54">
        <property type="entry name" value="CHROMATIN ACCESSIBILITY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="50"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW81834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="135" mass="15175" checksum="7E397A7CF3766D51" modified="2014-03-19" version="1">MEGESTISPPLEPAENAPTDSTPTEQNQPQEKKRTKACPQEVREGGKSLLPLARVQRIMKADKELPIVAKEAAFLISMAAEEFIKRLAEASQKTSLDRDRKSKVIQQRDIASVVRRVDEYLFLEGEDVRARIDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4K824</accession>
    <name>W4K824_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 monooxygenase 83</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cyp83</name>
        <name evidence="10" type="ORF">HETIRDRAFT_61437</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545877.1">
        <property type="nucleotide sequence ID" value="XM_009547582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K824"/>
    <dbReference type="STRING" id="747525.W4K824"/>
    <dbReference type="GeneID" id="20678558"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_61437"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_5_11_1"/>
    <dbReference type="InParanoid" id="W4K824"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="381"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="381"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW81977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="641" mass="69362" checksum="735E262DB750F6FA" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4K848</accession>
    <name>W4K848_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Short-chain dehydrogenase/reductase SDR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_475518</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546586.1">
        <property type="nucleotide sequence ID" value="XM_009548291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K848"/>
    <dbReference type="STRING" id="747525.W4K848"/>
    <dbReference type="GeneID" id="20677631"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_475518"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_1"/>
    <dbReference type="InParanoid" id="W4K848"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03445)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW82002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="28735" checksum="921BCBAD4FB27D76" modified="2014-03-19" version="1">MSGQGKVAVITGSSSGIGRATAIALSQEGWSLMLTARREAQLQETRTLCIDARKAVGLPSEDGKFLVAAGDITNEDFVKGLFQKTVDSFSRLDMLFNNAGISAPATPTEEFSLDLFNAVLSTNVIGPFLCTREAVRIFKRQIPQGGRIINNGSLSAHMPRPHSVAYTTAKHAILGLTKCTALDGRPHNITCTQIDIGNANTTISTASNNQFSGAPSSTAVMHLQPNGQVTPEDTMDPAYAAAQIVSVAALPNTVTVLSLNIMATNMPYVGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4K899</accession>
    <name>W4K899_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_45861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545814.1">
        <property type="nucleotide sequence ID" value="XM_009547519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K899"/>
    <dbReference type="GeneID" id="20676930"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_45861"/>
    <dbReference type="HOGENOM" id="CLU_180976_0_0_1"/>
    <dbReference type="InParanoid" id="W4K899"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="65" mass="7457" checksum="61E55280D74300D1" modified="2014-03-19" version="1" fragment="single">EESCYILDLPDTNNTFSIFHSSLLYPFHDSNHACFLSYYILCPGLIITINGIEEFEVGAIINKHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8V2</accession>
    <name>W4K8V2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PRP1 splicing factor N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_383832</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546139.1">
        <property type="nucleotide sequence ID" value="XM_009547844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8V2"/>
    <dbReference type="FunCoup" id="W4K8V2">
        <property type="interactions" value="596"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K8V2"/>
    <dbReference type="GeneID" id="20672171"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_383832"/>
    <dbReference type="eggNOG" id="KOG0495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007010_0_0_1"/>
    <dbReference type="InParanoid" id="W4K8V2"/>
    <dbReference type="OrthoDB" id="440128at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000256">
        <property type="entry name" value="Probable pre-mRNA splicing factor prp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000384">
        <property type="entry name" value="Probable pre-mRNA splicing factor prp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010491">
        <property type="entry name" value="PRP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06424">
        <property type="entry name" value="PRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13428">
        <property type="entry name" value="TPR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="7">
        <location>
            <begin position="16"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW81496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="917" mass="101841" checksum="C79138E93855FF3C" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4K949</accession>
    <name>W4K949_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_475048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009547947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K949"/>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_475048"/>
    <dbReference type="eggNOG" id="ENOG502QVG4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053011_0_0_1"/>
    <dbReference type="InParanoid" id="W4K949"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="39312" checksum="DE68329307199E34" modified="2014-03-19" version="1">MLREYGYANAVAIRPPSIRNWTEEQVDHFLEHGYIVIKGAFTPQKAAEWTKDIWARLGMDPDDKSTWDRERIHMPAHRRETVASFAPKAWGAMKELLGGEERIDEESSAWGDSFIVNLGTDELEGDDKGVDPKDLGIWHVDGDFFVHFLDSPEQALLVIPIFSAIKPRGGGTYICTDGLDKIARHLAAHPEGVRPTPLSFTPADSTYADPADDPGYWSHLKAVQTCSTFVELTGDVGDVVLLHPLMLHSASKNHLRVPRVITNPPVALREPFQFHRQNPDDYSLVERKTLRALGVDRLAFEIASPRRRIVPNRLRIQAKMLEEEKRRLEELEKGMKAVDISSTRLVAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9B2</accession>
    <name>W4K9B2_HETIT</name>
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        <recommendedName>
            <fullName evidence="15">Mitochondrial Rho GTPase</fullName>
            <ecNumber evidence="15">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HETIRDRAFT_36706</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 15">Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Mitochondrion outer membrane</location>
            <topology evidence="2 15">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the mitochondrial Rho GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="15"/>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545782.1">
        <property type="nucleotide sequence ID" value="XM_009547487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9B2"/>
    <dbReference type="FunCoup" id="W4K9B2">
        <property type="interactions" value="362"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K9B2"/>
    <dbReference type="GeneID" id="20671826"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_36706"/>
    <dbReference type="eggNOG" id="KOG1707">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014255_3_0_1"/>
    <dbReference type="InParanoid" id="W4K9B2"/>
    <dbReference type="OrthoDB" id="10020961at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01893">
        <property type="entry name" value="Miro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01892">
        <property type="entry name" value="Miro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000011">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000553">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001330">
        <property type="entry name" value="Mitochondrial Rho GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013566">
        <property type="entry name" value="EF_hand_assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013567">
        <property type="entry name" value="EF_hand_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021181">
        <property type="entry name" value="Miro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052266">
        <property type="entry name" value="Miro-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020860">
        <property type="entry name" value="MIRO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08355">
        <property type="entry name" value="EF_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08356">
        <property type="entry name" value="EF_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037488">
        <property type="entry name" value="Mt_Rho_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51423">
        <property type="entry name" value="MIRO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 15" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Miro" evidence="17">
        <location>
            <begin position="2"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="186"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="306"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="17">
        <location>
            <begin position="415"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETW81671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="643" mass="71891" checksum="B86DDD6577BF98E9" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9C0</accession>
    <name>W4K9C0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_64973</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545895.1">
        <property type="nucleotide sequence ID" value="XM_009547600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9C0"/>
    <dbReference type="FunCoup" id="W4K9C0">
        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K9C0"/>
    <dbReference type="GeneID" id="20678707"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_64973"/>
    <dbReference type="eggNOG" id="KOG0439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032848_1_0_1"/>
    <dbReference type="InParanoid" id="W4K9C0"/>
    <dbReference type="OrthoDB" id="264603at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160219">
        <property type="term" value="C:cortical endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140506">
        <property type="term" value="F:endoplasmic reticulum-autophagosome adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160214">
        <property type="term" value="F:endoplasmic reticulum-plasma membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033149">
        <property type="term" value="F:FFAT motif binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
        <property type="term" value="P:endoplasmic reticulum membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051685">
        <property type="term" value="P:maintenance of ER location"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902647">
        <property type="term" value="P:negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000813">
        <property type="entry name" value="Vesicle-associated protein 1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016763">
        <property type="entry name" value="VAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809:SF6">
        <property type="entry name" value="AT11025P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019693">
        <property type="entry name" value="VAMP-associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="8">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="256"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW81681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="325" mass="35133" checksum="33E6DC6162420944" modified="2014-03-19" version="1">MSVTLQPSNSLGFNRPLTQTVKRSLAITNPNAQPVAFKVKTTAPKLYCVRPNSGTVEPGETVEVQVMLQAMKEEPPLNVKCKDKFLIQSTLITPDKGASHDIWTVSEGEDPDKIKSQKIKVVYLPPDGQVVEEEDEGHANQPSMIIPGPSRYETVRGAPSVARPAESIMQRSLTPPADFSAAREDVHEEPVVVPESHSGNVGVVNVNVHTPQPPTPPAAPVPIPVPPVVDPNPQLLAKLKEMQSENQRLRALLAAVPDPSSVASSGTSPTELRRRHRPTSDDGTTTVESDVGTYYDDGALQAEGVPLQVVVIIALLIFITTYLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9G3</accession>
    <name>W4K9G3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_416578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544739.1">
        <property type="nucleotide sequence ID" value="XM_009546444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9G3"/>
    <dbReference type="STRING" id="747525.W4K9G3"/>
    <dbReference type="GeneID" id="20673337"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_416578"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001324_5_4_1"/>
    <dbReference type="InParanoid" id="W4K9G3"/>
    <dbReference type="OrthoDB" id="2272314at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="56884" checksum="88E9D106D9F04CB0" modified="2014-03-19" version="1">MFQHSVYHGATAYQIPEQYPIYAPPPMPAPPPHYWPVNVSAYPSLLQHLIGNHDRQARTRLAAASHPDYERRMMNKFEQSHAERRRCCRENTRPESDVFPHNPASSSYRPQPPLPPQLDVQALQYQHEQQAFDQHRAFLHEQHLEEVRQQLLQPQQRHQQHELQRQEEGIHEQAFFQQQHLDDLQQQQHLQNQIQVHLEEQEHYANLAIQQNYHALAQNQVMQQLPLGRRPYQEPDARYSVGHMDVECSHCKALHFSSEKLSSSTHNHIRFGMCCLQGQIRLPVLLDPPQTLRDLLCGDTENAKSFRLNIRQYNSAFAFNSIAAKLSDHVTTTSGPYAFKIHREIYHQMGTLLPPNHLRPSYALLYVIDPQAALNERNNANPNLKSEIMNNLQDMFHEHNPYVPLYRHAYQIMADKNPGERDKLAARIAILPNTDHCCYNEPTAGGVAAIIPGSGDEEVDLHRDIVVHYNHGGLKHFSHLHPHYSPLHYVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9P1</accession>
    <name>W4K9P1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_317982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546643.1">
        <property type="nucleotide sequence ID" value="XM_009548348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9P1"/>
    <dbReference type="GeneID" id="20670465"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_317982"/>
    <dbReference type="HOGENOM" id="CLU_2190175_0_0_1"/>
    <dbReference type="InParanoid" id="W4K9P1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="109" mass="12233" checksum="B4841B3345ACDE8D" modified="2014-03-19" version="1" fragment="single">VEDVVILFCHVERLGQIGNRVPSVVWGFLRQDHSGGKVGSISFKLERAFAIRVDEDWSRGETVFQVFEGSVPLVGPREQDVFLCEVIERSGHGSEVFDEPSVEVFKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KA79</accession>
    <name>W4KA79_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_115550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546791.1">
        <property type="nucleotide sequence ID" value="XM_009548496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KA79"/>
    <dbReference type="GeneID" id="20666487"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_115550"/>
    <dbReference type="HOGENOM" id="CLU_1610977_0_0_1"/>
    <dbReference type="InParanoid" id="W4KA79"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="165" mass="17177" checksum="6A9339CC45702C50" modified="2014-03-19" version="1">MCVGRDEPKACRSARREISTVVWLPAHSVINPPAITHPRLGETGEGGGNHAPPCILSPCGPLDVDTVPSAARKASLPRLKTHPRCVGVSVSGTPRSSKLQTAMPGTVQDQKSPEGPAAHGSALLPASSYMDAIPVSATEADPQGSATLQGSSRAEHDIHDTRLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAG7</accession>
    <name>W4KAG7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_417903</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546872.1">
        <property type="nucleotide sequence ID" value="XM_009548577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAG7"/>
    <dbReference type="STRING" id="747525.W4KAG7"/>
    <dbReference type="GeneID" id="20673428"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_417903"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027074_7_0_1"/>
    <dbReference type="InParanoid" id="W4KAG7"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140096">
        <property type="term" value="F:catalytic activity, acting on a protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990444">
        <property type="term" value="F:F-box domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062026">
        <property type="term" value="P:negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070372">
        <property type="term" value="P:regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000036">
        <property type="entry name" value="Serine/threonine/tyrosine-interacting protein a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052449">
        <property type="entry name" value="STYX-Interacting_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588">
        <property type="entry name" value="SERINE/THREONINE/TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588:SF1">
        <property type="entry name" value="SERINE_THREONINE_TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="30"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="96"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW82345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="227" mass="25891" checksum="106DAD91177F0BAF" modified="2014-03-19" version="1">MASIIPTGKDLQDLISGPADVEWKYDMRHQCQEILPGLLLGPFVVSKSLESLRNLRITHIVCIRDAKEAFSVRPRFPEAFSYLVLDVQDSEEQNLIRLFPKAREFINAALAQGGRVLVHCNGGISLSPAFVIMYVMQQCQMSWEDALHMVQNRRYCISPNAGFLTQMKEYESIYRAGLAVSMYSNAQRDAPRRKRELEEDEDEREDKRIILMESAVIAPDPNAMDHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAM9</accession>
    <name>W4KAM9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_144852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544784.1">
        <property type="nucleotide sequence ID" value="XM_009546489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAM9"/>
    <dbReference type="GeneID" id="20667054"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_144852"/>
    <dbReference type="HOGENOM" id="CLU_3068944_0_0_1"/>
    <dbReference type="InParanoid" id="W4KAM9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="61" mass="6507" checksum="297115E6716DE227" modified="2014-03-19" version="1">MHPPLHAIPVRPRASPCPVKPKLDSSSPHLPATECPRSLSSLELTHPPSPATQIRPRSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAV3</accession>
    <name>W4KAV3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_433701</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545260.1">
        <property type="nucleotide sequence ID" value="XM_009546965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAV3"/>
    <dbReference type="STRING" id="747525.W4KAV3"/>
    <dbReference type="GeneID" id="20674694"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_433701"/>
    <dbReference type="eggNOG" id="KOG3140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041954_2_0_1"/>
    <dbReference type="InParanoid" id="W4KAV3"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="11">
        <location>
            <begin position="99"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW82962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="291" mass="32257" checksum="BBFECB9A058C0F53" modified="2014-03-19" version="1">MTPTNKADRGLPSRLLSTSQHYIALAFHRFQQLHLFGKILVCLLFLFYLALGLFIVVVTPARIAQFLYDGAQKLNNLPFGWALIGLVIVIISIPPMIGHTTMLHVCGFAYGLKGFPLAAAASVIGSSAVFLALRFLFGKKLRAWSSSNDKWQALETVINAKGLPLIILIRVSSFPPWVYSNTLFASIQTVSIWQFVVATICIFPRFLLYVFIGSRMAALSDGNQRNKMDTQTKIINGFLIAGGLTISVIASWIVYTLMQRQLRQLSPELDERVEEALENADEGAPLLHSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAZ7</accession>
    <name>W4KAZ7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_54650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544650.1">
        <property type="nucleotide sequence ID" value="XM_009546355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAZ7"/>
    <dbReference type="FunCoup" id="W4KAZ7">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KAZ7"/>
    <dbReference type="GeneID" id="20678312"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_54650"/>
    <dbReference type="eggNOG" id="KOG3069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040940_2_2_1"/>
    <dbReference type="InParanoid" id="W4KAZ7"/>
    <dbReference type="OrthoDB" id="10260614at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015938">
        <property type="term" value="P:coenzyme A catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF45">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="41"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="277" mass="30774" checksum="5236FF9099AE1799" modified="2014-03-19" version="1">MDHSIAPVATLTGLSDQSRACLERLQSHQPEQVDLTTYPASKLASVLILLYDKAGELRVLLTTRSKSLRSHPGQTALPGGKVDETDRDAIHTAYREANEEVRLPLESPHVHTVCTLRPFLSPYRLLVTPVVAYLDDASLLDELQASDEEVEHIFDHPLEGLLDPTISRKESLVPIGGEHWPYETELHNTSDNHFALLGDSLYRMHRFRTTASPIKGLTSDILIFTAEIAYEREPAYERWAPGQLSGLASVRLVLENDGKSVIGYQTSQVSMPDGART</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4KB33</accession>
    <name>W4KB33_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_314827</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PH_5"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="41"/>
            <end position="234"/>
        </location>
    </feature>
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        <location>
            <begin position="269"/>
            <end position="408"/>
        </location>
    </feature>
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        <location>
            <begin position="448"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW83047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="808" mass="89151" checksum="DB898A8A96EA49F6" modified="2014-03-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBG9</accession>
    <name>W4KBG9_HETIT</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
    <gene>
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    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="20677555"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_474219"/>
    <dbReference type="eggNOG" id="ENOG502RY7K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046025_2_0_1"/>
    <dbReference type="InParanoid" id="W4KBG9"/>
    <dbReference type="OrthoDB" id="3183258at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="168"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW83074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="282" mass="30784" checksum="7EEDD9AC6C2F64B2" modified="2014-03-19" version="1">MSDAGATLAKLLHGPMLAGTFINAVLYGVSITQVYIYVKTFRTTDKQWIKGFIAVLFALDTINTVFDMAFMYDSVISHFGDVAYIQNANWIFCTDPALTGVIGVTVQLFFAWRVKILTGSTAASIVIALTAILQCLAGIATSIAVGFIPAYLEFRRFKPAVIVWLAGSAACDTMITIVLVWHLRRHKGGFSTTDDVIDRIIRVTVQTGMLTSLVALIDLVLFISSPSGLHLAFNFPLSKLYTNSLLSSLNSRKGWAFTSTSDQTASATADRRTKRVSSCQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBS5</accession>
    <name>W4KBS5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_417247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545571.1">
        <property type="nucleotide sequence ID" value="XM_009547276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBS5"/>
    <dbReference type="GeneID" id="20673395"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_417247"/>
    <dbReference type="HOGENOM" id="CLU_1986836_0_0_1"/>
    <dbReference type="InParanoid" id="W4KBS5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW83302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="148" mass="16683" checksum="1EF0B09DA1DC0BC4" modified="2014-03-19" version="1">MMVSLAYSHKGAVVVDKCIQRRLFTVTQGQDLVSHDPNLIVYAGVDGMFGHFNLFIVGFLHRHPSVSNLLIDLSSGVCTDEQILNNKCRRYVVGGFEFLKTTSHLKRCYGFLIDGDFALRWKDQCEAARHHSPLTISNLSFVLFCGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KC79</accession>
    <name>W4KC79_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_165659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545634.1">
        <property type="nucleotide sequence ID" value="XM_009547339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KC79"/>
    <dbReference type="GeneID" id="20667998"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_165659"/>
    <dbReference type="HOGENOM" id="CLU_050560_0_0_1"/>
    <dbReference type="InParanoid" id="W4KC79"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="441" mass="48147" checksum="3A40C329B0E6E446" modified="2014-03-19" version="1">MLLHEDHDASSPSRNSSPNVVLMVSNPDIGRVDRGTSPHLSNAGRIDRGTSPHHPEPAVVTLTPHLNNFSDDDAEDYAKFKERERTRRPSSQGAPRDASRNENPDDRNLPGSDEVPVGVPPPATIAASIGAAGPSGLRARTAAQLPSHGETESIPVIQGATPPPVPTGGQIPRSMGRTTLGANPHAGELERHADALLQRSTISAVIQMATAMALQRLANFAAGQPGNEHSDIPRRLASASLQIRGLALQTDPDTASWYEHNDGRPRALLIHPDEFSQYVNRELLPALLFTGELGAVQPSRTDPFRVVVWNVPRPGEHPTAVPNPRRAPRTVVERPSPRPRESRPTHSNPTTSPSHRVRNFPLSHGGTNEEEPPVYRRNEGRRSQGTQATLRRRTTTGGSVRHRPGTPPPSARFRTDEGQNNRSSRRTRRADSEARRNRSWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCK2</accession>
    <name>W4KCK2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_157213</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545354.1">
        <property type="nucleotide sequence ID" value="XM_009547059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCK2"/>
    <dbReference type="FunCoup" id="W4KCK2">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KCK2"/>
    <dbReference type="GeneID" id="20667707"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_157213"/>
    <dbReference type="eggNOG" id="KOG2399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004979_2_0_1"/>
    <dbReference type="InParanoid" id="W4KCK2"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844152" description="Sodium/calcium exchanger membrane region domain-containing protein" evidence="9">
        <location>
            <begin position="23"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="588"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="613"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="672"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="703"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="746"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="774"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="110"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="650"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="278"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW83070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="803" mass="87617" checksum="1D010A1D40E6219F" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCL8</accession>
    <name>W4KCL8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_106974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545115.1">
        <property type="nucleotide sequence ID" value="XM_009546820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCL8"/>
    <dbReference type="GeneID" id="20666202"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_106974"/>
    <dbReference type="HOGENOM" id="CLU_571842_0_0_1"/>
    <dbReference type="InParanoid" id="W4KCL8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="478" mass="52250" checksum="B069EEEA0FD61B8C" modified="2014-03-19" version="1" fragment="single">MVLAFFCPNDIHALPQTYRGNDSIERCTQNQVEAFRFKEIRISGQPTTTLMRFHLTCSVLDGMRSIAHPFTSEKLWHLPKRANRMSRQWSSAISHTPKVSLTGDPSPDTISPPYHMQPQNLDPPPLPLATLQTPTRRPGHQLHLNPPRMPLIDIIFPKPITARSNKHIALRPQRHTLKRNRPSRRSNQARTNPISPSPVVFASFPFPSPVHSLSRPSPRASSTQAAPTRGPRTKPKPGGFDAAGARASRASLIPDREPQARQRACARAMTRARDRRGDSGHRLSSARRGALGYVTRGDGRAGVPRATLRGTQPPCPGPAEITVARIPRTDGVPRARFAGSSFDASTLRASTLKRRACHLRSASRLIRSRQKTPGRGPRPRTQNPEPRNPEPQSPRTPSSSQPASQPAPSVQTPPASLLRSSRACADATIGPAESIERALHSPSQLVPARIAPPPSSRSASDGSDPKPSLAPRETASRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KD28</accession>
    <name>W4KD28_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GMC oxidoreductase 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gor15</name>
        <name evidence="6" type="ORF">HETIRDRAFT_48370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543235.1">
        <property type="nucleotide sequence ID" value="XM_009544940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KD28"/>
    <dbReference type="STRING" id="747525.W4KD28"/>
    <dbReference type="GeneID" id="20678065"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_48370"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_5_1_1"/>
    <dbReference type="InParanoid" id="W4KD28"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF78">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="551"/>
            <end position="552"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW83644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="620" mass="67273" checksum="D695D048002A1AAC" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDH0</accession>
    <name>W4KDH0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dihydroorotase</fullName>
            <ecNumber evidence="3">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_472145</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="3"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543574.1">
        <property type="nucleotide sequence ID" value="XM_009545279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDH0"/>
    <dbReference type="FunCoup" id="W4KDH0">
        <property type="interactions" value="282"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KDH0"/>
    <dbReference type="GeneID" id="20677441"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_472145"/>
    <dbReference type="eggNOG" id="KOG2902">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041558_0_0_1"/>
    <dbReference type="InParanoid" id="W4KDH0"/>
    <dbReference type="OrthoDB" id="1670005at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01294">
        <property type="entry name" value="DHOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000071">
        <property type="entry name" value="Dihydroorotase, homodimeric type, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00219">
        <property type="entry name" value="PyrC_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004721">
        <property type="entry name" value="DHOdimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00856">
        <property type="entry name" value="pyrC_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137:SF1">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001237">
        <property type="entry name" value="DHOdimr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="8">
        <location>
            <begin position="78"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW83833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="354" mass="38978" checksum="25868717757A61F2" modified="2014-03-19" version="1">MSSTPTVTVCSPADFHVHLRQGALSALVVPHVALGGFQLAYVMPNLKPPISTTDQALEYKANLERIDPTIEYLMTLYLSPDLTPDEIRKAKKAGIVGVKSYPRGVTTNSDGGIESYEAYYPVFEAMEEVDMVLNLHGEVPSDASANIHVINAELSFLPHLRKLHTRFPRLRIVLEHATTRAAVETVKSLGPAVACTITAHHLALTVDDWAGQSWNFCKPVAKFPDDREALREVIREGHPRFFLGSDSAPHPPSTKSTSTPTHACAAGVYTSPILLPLTAHLLESFGALDNLEGFVSTFGRKFYGREVANRADHSRQVRLRKVTGQRVTESWTVNGESVVAFWTGKDLDWEIVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4KE05</accession>
    <name>W4KE05_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_170452</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543706.1">
        <property type="nucleotide sequence ID" value="XM_009545411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KE05"/>
    <dbReference type="FunCoup" id="W4KE05">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KE05"/>
    <dbReference type="GeneID" id="20668285"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_170452"/>
    <dbReference type="eggNOG" id="KOG1310">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012381_2_0_1"/>
    <dbReference type="InParanoid" id="W4KE05"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF40">
        <property type="entry name" value="WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="59"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW83984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="55143" checksum="1D076715AC9B4010" modified="2014-03-19" version="1">MTVPVLSDIIVLRCVNALSWAKDGQLLLSGGDDTTVRLWRIDQGETAQQYPFVCQGTVQTGHTGNIFNAQMLPSSNRIATVAGDKQVRVFDVTDTISQPANPLEADRGTQASHLRVLRCHAGRTKRIVTEHSSDLFLTVGEDGTVRQHDLRVHHVCRSGRCPPPLVKVPHELSTLALSPLTPYEFVVAGDSPYGYLFDRRQTGRFIQEEWGILPTGDDVTTCVRRFGRKSMGPGERKGHEHVTGARMSTRNGHEVLLSYSADAVYLYSTRDDVVDSSGSSTPPAVVAPNTKHKVQVANQPSEDLMEGIESEWSASDADVVDSDPEIQGNSSSGDQTDIFEDIEESINDGIPVLHGTLPVIYPRMCFAGACNVQTVKDVNFFGPSDEFVVSGSDDGNFFVWRKTTGALHGVYEGDGSVVNVIESHPHLPLVAVSGIDTTVKLFAPVQHSSKFSRMSDAESIVSRNLEAASREENEYSALFNHYRLMLGELGRHYGEEGQPGCTFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4KE20</accession>
    <name>W4KE20_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">O-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_314301</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543779.1">
        <property type="nucleotide sequence ID" value="XM_009545484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KE20"/>
    <dbReference type="FunCoup" id="W4KE20">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KE20"/>
    <dbReference type="GeneID" id="20670109"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_314301"/>
    <dbReference type="eggNOG" id="KOG1663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067676_8_0_1"/>
    <dbReference type="InParanoid" id="W4KE20"/>
    <dbReference type="OrthoDB" id="10251242at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050362">
        <property type="entry name" value="Cation-dep_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509:SF14">
        <property type="entry name" value="CAFFEOYL-COA O-METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509">
        <property type="entry name" value="O-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW84063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="25547" checksum="2025B47AC708F5CC" modified="2014-03-19" version="1">MAPSLPGHELAQRPTTREDWTRSDLYHNSFLISWDEALEFALKNSDEKGLPQIAVSAAQGKFLYLLAKSLGANRILEVGTLGGYSTIWLARALPADGNIITCELDKKHADTAQENLTHAGLESKVNVLVGPAAESLRNLHPDQPFDCVFIDADKPGNKTYYIEAKRLVRKGGVIIVDNVVRNGLVSDPSHTDASCEGVRELLTYMKDDKEVEATTMATVGEKGYDGFLYAIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4KE82</accession>
    <name>W4KE82_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Orm1 type endoplasmic reticulum protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_242658</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
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                <person name="Cullen D."/>
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                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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                <person name="Broberg A."/>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="375" mass="41381" checksum="394B6EA5C22595E6" modified="2014-03-19" version="1">MPNAVRRHLHGSHNLFDIHHLARLISAIRLFSFADSASQSQRGFNSRANLAMLLATLVMFASSTASWALGFTVIIKLIENELLVDPDQPLESKYAMVNQSVFGMNISLPYLALVNYLIGDAIVVWRAWVLWRNSPKVMTVPIVLWTCSVGPKSRPKFHDNTEVTFNLSLIIVASVLFGVFQIISISVPTHRMGIMTGYSQLASWAFELATNIVATSLIGYKTWTYRRFIRQNIIGKNRKTSIQKILAILVESGILYCFVWIALIVCGTVPISGVRAVDAGASADLFLSVSSHIAGIYPTIIVVLVSMQNTVWDVSGFTSDVLSKPQFIAPETDILPKTTGHESISRPTLSTKTSASTQIGDADWLELKADARQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGS0</accession>
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                <person name="Aerts A."/>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Duplessis S."/>
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                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
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                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541723.1">
        <property type="nucleotide sequence ID" value="XM_009543428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGS0"/>
    <dbReference type="STRING" id="747525.W4KGS0"/>
    <dbReference type="GeneID" id="20669247"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_25488"/>
    <dbReference type="eggNOG" id="ENOG502SJ45">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004591_0_2_1"/>
    <dbReference type="InParanoid" id="W4KGS0"/>
    <dbReference type="OrthoDB" id="2506088at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912:SF34">
        <property type="entry name" value="NOTOCHORD-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="266" mass="29828" checksum="99446AB64D79E515" modified="2014-03-19" version="1" fragment="single">DNPMQAELSSGAGLNSNFFCRTCHVGGSQEHKRSDVGFGSIFEVSGAVRDSGVKDGVAQPIIDHIVKLGQQLRKSSSPEQIAHSPEEVQAILTEELRVDIHKDTPTEILHTILLGIVKYFWGQTVFFLEKAKQFHIFQIHLNSIASDGLNIPAIPADYICQYKGALIGKHFKTLSQIMAFTIYDLVPQNVLDAWLLISHLTVMLWHTEIDDMNVYLAKLQQCIDDILDVTALCSPSILISKPKFHFLVHLPFYIRRFGPAILYSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHK5</accession>
    <name>W4KHK5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_310866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542199.1">
        <property type="nucleotide sequence ID" value="XM_009543904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHK5"/>
    <dbReference type="GeneID" id="20669809"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_310866"/>
    <dbReference type="HOGENOM" id="CLU_147768_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHK5"/>
    <dbReference type="OrthoDB" id="3245189at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="148" mass="16714" checksum="3EBA155925FA6024" modified="2014-03-19" version="1" fragment="single">AVSWGLERQQASSAVSTWGIENVLVEEKQQQFVSLPCGLLFSININWFSPIKRLHAYSTSAIYVIILNNPRSKHFLAQEMLLYCVIPGPHKPTLEQLNEIMEPLVKEFQELYKGECMVCVSGKEKTAINGLTFLQAGVAIIWKTTPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHM0</accession>
    <name>W4KHM0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_439355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544424.1">
        <property type="nucleotide sequence ID" value="XM_009546129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHM0"/>
    <dbReference type="FunCoup" id="W4KHM0">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KHM0"/>
    <dbReference type="GeneID" id="20675129"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_439355"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="InParanoid" id="W4KHM0"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW84795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="347" mass="37729" checksum="654DB6E73BEB3C6A" modified="2014-03-19" version="1">MPAVASPSKVLVSGANGYIAAWVVRTLLEKGYAVRGTVRSDAKGAHLKKLFAEHGDKFEVVIVEDITKEGAFDEAVKGVDLIEHTASPFHFNFKEPNDLIVPATKGTLGMLESAKKHGSSVKRIVVTSSCASVLKPSATPAVWEETSWNEPAIEEVKEKGANALPISIYRASKTLAEKAAWDFYEKNKTSVGWDLVVLNPPYVFGPPIHEVTSMSAFNTSMQEFFNTVVKGVKDDAALKTLGSAWIDVRELANAHVLAAETPEASGERIIVSAGAFYWQEIVDAANRISPPPLTSIVKGNPGSTKGITHLIDYNTAKSDRILKLKHRPLEELIRDCLLDFKARGYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHQ3</accession>
    <name>W4KHQ3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Single hybrid motif-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_309435</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542227.1">
        <property type="nucleotide sequence ID" value="XM_009543932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHQ3"/>
    <dbReference type="STRING" id="747525.W4KHQ3"/>
    <dbReference type="GeneID" id="20669677"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_309435"/>
    <dbReference type="eggNOG" id="KOG0557">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035825_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHQ3"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF82">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE COMPLEX PROTEIN X COMPONENT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="10"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="6">
        <location>
            <begin position="138"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW85362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="29078" checksum="62F25A8CD82EEBAA" modified="2014-03-19" version="1" fragment="single">LHSTSARRAITNMEMPAMSPTMNEGGISSWKKKEGESFIAGDVLLEIETDKAIIDVEAQEDGVMGKIIVPDGAKNIPVGQLIALLAEEGDDISNLEIPKLKPAVAKPDETPKSEATPPPPSPSPVPPHPAKYIEYSRPLFPSVSRLLQEHDIPDLEKIKGTGVRGMLTKGDVLAYLGKASSPTGTFKEAQKTAEAPRKVEAEPLDGGAIRRLIVGNFYQSSVKARASAAPKLSADFDSIISDYLPSSTLPSSRRAESQKHQSTSASFLDGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHX0</accession>
    <name>W4KHX0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">mRNA cap guanine-N(7) methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">mRNA (guanine-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">mRNA cap methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_311168</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for methylating the 5'-cap structure of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67008"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.56" evidence="2"/>
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        <property type="protein sequence ID" value="ETW85458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542319.1">
        <property type="nucleotide sequence ID" value="XM_009544024.1"/>
    </dbReference>
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        <property type="interactions" value="732"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KHX0"/>
    <dbReference type="GeneID" id="20669845"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_311168"/>
    <dbReference type="eggNOG" id="KOG1975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020346_4_1_1"/>
    <dbReference type="InParanoid" id="W4KHX0"/>
    <dbReference type="OrthoDB" id="10248867at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189:SF2">
        <property type="entry name" value="MRNA CAP GUANINE-N7 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="MRNA GUANINE-7- METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="mRNA_G-N7_MeTrfase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51562">
        <property type="entry name" value="RNA_CAP0_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="13">
        <location>
            <begin position="222"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="142"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW85458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="556" mass="59830" checksum="8707F03DF6D65F28" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJJ7</accession>
    <name>W4KJJ7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ARM repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_457591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542813.1">
        <property type="nucleotide sequence ID" value="XM_009544518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJJ7"/>
    <dbReference type="STRING" id="747525.W4KJJ7"/>
    <dbReference type="GeneID" id="20676849"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_457591"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007321_1_1_1"/>
    <dbReference type="InParanoid" id="W4KJJ7"/>
    <dbReference type="OrthoDB" id="26149at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040144">
        <property type="entry name" value="RAP1GDS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10957">
        <property type="entry name" value="RAP1 GTPASE-GDP DISSOCIATION STIMULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="749" mass="81906" checksum="6CFF8191BF03843F" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJL1</accession>
    <name>W4KJL1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinetochore protein NDC80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_443511</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
            <location evidence="10">Centromere</location>
            <location evidence="10">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the NDC80/HEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542359.1">
        <property type="nucleotide sequence ID" value="XM_009544064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJL1"/>
    <dbReference type="FunCoup" id="W4KJL1">
        <property type="interactions" value="197"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KJL1"/>
    <dbReference type="GeneID" id="20675527"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_443511"/>
    <dbReference type="eggNOG" id="KOG0995">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012583_1_1_1"/>
    <dbReference type="InParanoid" id="W4KJL1"/>
    <dbReference type="OrthoDB" id="7459479at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.30">
        <property type="entry name" value="Ncd80 complex, Ncd80 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005550">
        <property type="entry name" value="Kinetochore_Ndc80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055260">
        <property type="entry name" value="Ndc80_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038273">
        <property type="entry name" value="Ndc80_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03801">
        <property type="entry name" value="Ndc80_HEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 10" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Ndc80 CH" evidence="13">
        <location>
            <begin position="105"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="276"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="387"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="497"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW85505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="635" mass="71884" checksum="9E6DDDF1B8C8FCDD" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJS6</accession>
    <name>W4KJS6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ATP synthase subunit beta</fullName>
            <ecNumber evidence="17">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HETIRDRAFT_145736</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="17"/>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542892.1">
        <property type="nucleotide sequence ID" value="XM_009544597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJS6"/>
    <dbReference type="FunCoup" id="W4KJS6">
        <property type="interactions" value="214"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KJS6"/>
    <dbReference type="GeneID" id="20667096"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_145736"/>
    <dbReference type="eggNOG" id="KOG1350">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022398_0_2_1"/>
    <dbReference type="InParanoid" id="W4KJS6"/>
    <dbReference type="OrthoDB" id="14523at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.170:FF:000004">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000006">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 17" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="8 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 17" id="KW-0139">CF(1)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="212"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ETW86118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="544" mass="58471" checksum="E8CEC22CC4F17FE3" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KK23</accession>
    <name>W4KK23_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_415178</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542973.1">
        <property type="nucleotide sequence ID" value="XM_009544678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KK23"/>
    <dbReference type="STRING" id="747525.W4KK23"/>
    <dbReference type="GeneID" id="20673225"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_415178"/>
    <dbReference type="eggNOG" id="ENOG502S7GW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041922_0_0_1"/>
    <dbReference type="InParanoid" id="W4KK23"/>
    <dbReference type="OrthoDB" id="429967at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052115">
        <property type="entry name" value="NEXT_complex_subunit_ZCCHC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13316:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13316">
        <property type="entry name" value="ZINC FINGER, CCHC DOMAIN CONTAINING 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW86213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="420" mass="47564" checksum="F2819302D28F850C" modified="2014-03-19" version="1">MLYFCDVQRVSPRIHPDPGPEFRWTYRSASPPILYDRHGERILGELDDDSEEEADNGLSRCFNCGSTKHLVTHCPDPYNPHLVSLSRQLFSFFRSERTMEPKTLSEAFESKHQRLLFLDTFTPGEIRGPILREALNLRVDDIGESMPWLKWIAEWGYPRGWATKSDPRDTVRRRIENQFVGDLTIEEGQGSFTIYGEDVVEELDLSRPSELTFSQALQGNDLTLKNMYPNDPSFDLSDSEEETLNPSCEDSALHNLRPSSTPPRRWAIYPSTYFSNDLLPIYSGHRLPSLRSRPTSSTYSDDRQSLWSSITSQLGPGSSSTQWANVQASSVGTGTHPWRLPGIFHISEDDSGVFAVRSRRWPLHELSPLPPPGPPPSPPPPPPLPSPSLSQQISKRSLSPEPQNNLWDENDSDMDMSDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKD0</accession>
    <name>W4KKD0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11 12">3.2.1.106</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HETIRDRAFT_150185</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
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        <property type="protein sequence ID" value="ETW85531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542382.1">
        <property type="nucleotide sequence ID" value="XM_009544087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKD0"/>
    <dbReference type="FunCoup" id="W4KKD0">
        <property type="interactions" value="409"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KKD0"/>
    <dbReference type="GeneID" id="20667355"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_150185"/>
    <dbReference type="eggNOG" id="KOG2161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007380_1_0_1"/>
    <dbReference type="InParanoid" id="W4KKD0"/>
    <dbReference type="OrthoDB" id="410058at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844490" description="Mannosyl-oligosaccharide glucosidase" evidence="14">
        <location>
            <begin position="17"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="16">
        <location>
            <begin position="24"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="15">
        <location>
            <begin position="275"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETW85531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="786" mass="89053" checksum="CC9AE16ABBB1A310" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKE8</accession>
    <name>W4KKE8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_115092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKE8"/>
    <dbReference type="GeneID" id="20666462"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_115092"/>
    <dbReference type="HOGENOM" id="CLU_083072_0_0_1"/>
    <dbReference type="InParanoid" id="W4KKE8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="292" mass="32652" checksum="EB2528351944D4AA" modified="2014-03-19" version="1">MPSNESTHLSSENTLIEQTPSTDPSIPSTPEMSVVEERSVPWDTDEEQAAREAEEGFSEYLEGLDEDERRQDEMIRLLTEDFDRPSPSHSPSPPPLIREANEGVIFPDRETYLTTPVAYMMGLIEGTPNTEFVSGPTRPEIQRALEILEEERSFVRHAQRALQIQEGTIIARINAGERKLMGLQNLRDSFHPADDPTPSTEYHMPTTAVVSRASSTASNGAPLRPMPGTYPTRTDRERGVYRFTPVSPRIHLLPAPPGLIRPSLRTRPPLPFTEYDSSESNTAPIILRPRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKK2</accession>
    <name>W4KKK2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_310015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542440.1">
        <property type="nucleotide sequence ID" value="XM_009544145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKK2"/>
    <dbReference type="GeneID" id="20669737"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_310015"/>
    <dbReference type="HOGENOM" id="CLU_163763_1_0_1"/>
    <dbReference type="InParanoid" id="W4KKK2"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="86" mass="9368" checksum="997AF1AB013DFF83" modified="2014-03-19" version="1">MKYGQTDPSAAEYPSEGCGQSGENRLCSVQVSVFGTHLVLFSISPKLPKYLSWTLAQVHAHYWVTASRIVSMNGTVTTPARLPLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKT4</accession>
    <name>W4KKT4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_58514</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540369.1">
        <property type="nucleotide sequence ID" value="XM_009542074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKT4"/>
    <dbReference type="FunCoup" id="W4KKT4">
        <property type="interactions" value="572"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KKT4"/>
    <dbReference type="GeneID" id="20678435"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_58514"/>
    <dbReference type="eggNOG" id="KOG0176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_4_2_1"/>
    <dbReference type="InParanoid" id="W4KKT4"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03753">
        <property type="entry name" value="proteasome_alpha_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000015">
        <property type="entry name" value="Proteasome subunit alpha type-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033812">
        <property type="entry name" value="Proteasome_alpha_type_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW86432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="241" mass="26572" checksum="779B9FE96F0A84FA" modified="2014-03-19" version="1">MFLTRSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTTVGVSTPFGVVLGVEKRVQSPLLESSTIEKIMEIDTHLGCAMSGLTADARTMVDHARVTAQNHAFTYDERIKVESATQAVCDLALRFGESVHDEDAMMSRPFGVALLIAGVDELGPQLFHTDPSGTFVQYSAKAIGSGSEAAQSELQDKWHKNMTLEEARVLTLRVLKQVMEEKLDHHNVQLAQVTQEGFEILDEAKLKVVIDAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKV0</accession>
    <name>W4KKV0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_432523</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542775.1">
        <property type="nucleotide sequence ID" value="XM_009544480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKV0"/>
    <dbReference type="STRING" id="747525.W4KKV0"/>
    <dbReference type="GeneID" id="20674614"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_432523"/>
    <dbReference type="eggNOG" id="ENOG502QUQG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006242_0_0_1"/>
    <dbReference type="InParanoid" id="W4KKV0"/>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF26">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="253"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="302"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW85980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1036" mass="111766" checksum="8C0C4C7AD0F6CB1A" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4KL22</accession>
    <name>W4KL22_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Argininosuccinate lyase</fullName>
            <ecNumber evidence="4">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_407662</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="4"/>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542588.1">
        <property type="nucleotide sequence ID" value="XM_009544293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KL22"/>
    <dbReference type="FunCoup" id="W4KL22">
        <property type="interactions" value="357"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KL22"/>
    <dbReference type="GeneID" id="20672620"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_407662"/>
    <dbReference type="eggNOG" id="KOG1316">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027272_2_1_1"/>
    <dbReference type="InParanoid" id="W4KL22"/>
    <dbReference type="OrthoDB" id="2561043at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000001">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="7">
        <location>
            <begin position="13"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="8">
        <location>
            <begin position="370"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW85761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="463" mass="51684" checksum="02EDD1CE3C951D9D" modified="2014-03-19" version="1">MSEKPTKQKLWGGRFTGKTDPLMHAFNQSLKYDQRMHAADIRGSIAYAKSLTKVGILTQDEETKITEGLAVVGQEWASGTFQPAPDDEDIHTANERRLSELIGPLGGKLHTGRSRNDQVATDMRIWLLDEVKEIEAGLCALIRVMVERADREVDYLMPGYTHLQRGQPIRWSHLLLSHAFSFRSDLERLRQLIPRISVLPLGSGALAGNPFCVDRDFLAAELGFQSVAENSLWGVGDRDFIIEFMMWASLTTTHLSRMSEDFIIYSTAEFGFITLSDAYSTGSSMMPQKKNPDSLELLRGKSGRVFGNAAGFMMTYKGLPSTYNKDLQEDKEPLFDTVSTVAACFRIAEGVIATLDVHPQRMRQALTMDVLATDLADYLVRKGIPFRETHHISGRAVALAESRKCQLNELTLGDFKSLSDKFSDDVHQIFDFEASVERRQAIGGPSRIMIKRQVSVLLAALGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W4KL84</accession>
    <name>W4KL84_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HETIRDRAFT_380383</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542894.1">
        <property type="nucleotide sequence ID" value="XM_009544599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KL84"/>
    <dbReference type="FunCoup" id="W4KL84">
        <property type="interactions" value="236"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KL84"/>
    <dbReference type="GeneID" id="20672017"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_380383"/>
    <dbReference type="eggNOG" id="KOG1147">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_1_2_1"/>
    <dbReference type="InParanoid" id="W4KL84"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00807">
        <property type="entry name" value="GlnRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000070">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1160.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000004">
        <property type="entry name" value="Glutamyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="entry name" value="Glutamyl-trna Synthetase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.800.10">
        <property type="entry name" value="Glutamyl-tRNA Synthetase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="14">
        <location>
            <begin position="47"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETW86120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="766" mass="85304" checksum="8D68D70E404C5859" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLQ3</accession>
    <name>W4KLQ3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cellobiose dehydrogenase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cdh2</name>
        <name evidence="4" type="ORF">HETIRDRAFT_122297</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542780.1">
        <property type="nucleotide sequence ID" value="XM_009544485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLQ3"/>
    <dbReference type="STRING" id="747525.W4KLQ3"/>
    <dbReference type="GeneID" id="20666776"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_122297"/>
    <dbReference type="eggNOG" id="ENOG502SYC2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081649_2_0_1"/>
    <dbReference type="InParanoid" id="W4KLQ3"/>
    <dbReference type="OrthoDB" id="413885at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF5">
        <property type="entry name" value="CELLOBIOSE DEHYDROGENASE CYTOCHROME DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844332" evidence="2">
        <location>
            <begin position="20"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="3">
        <location>
            <begin position="247"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW85986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="284" mass="29500" checksum="0F2DC58FBCE0D8B8" modified="2014-03-19" version="1">MVSGMILATFIACASFGKGFLTHSCLLTAQGNSPYCDSSSGICYQGYYDSSLDITVGLVFPPLTTATTPNATEFIAQLVAPVNYGWTGLSVGGTMANSLLFTLWPNGDEIIFGPRWTAGYVQPLLYSGPKITLLPDSTVNSTHIKASFRCQNCTVWEGGSIGSGNLNGFQLIAYVASTDTPVDDPSNVASNFTEHNDFDFFGLDLSTVHSSSYSSYVGGGSTSSTLAPTSTIQTSTSVTATSSAAGATQTKYGQCGGTGWTGPTICASGSTCTAVSAPYYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLR8</accession>
    <name>W4KLR8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Nuclear cap-binding protein subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">20 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_310541</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the RRM NCBP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542794.1">
        <property type="nucleotide sequence ID" value="XM_009544499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLR8"/>
    <dbReference type="FunCoup" id="W4KLR8">
        <property type="interactions" value="412"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KLR8"/>
    <dbReference type="GeneID" id="20669785"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_310541"/>
    <dbReference type="eggNOG" id="KOG0121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070952_0_2_1"/>
    <dbReference type="InParanoid" id="W4KLR8"/>
    <dbReference type="OrthoDB" id="201398at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12240">
        <property type="entry name" value="RRM_NCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000538">
        <property type="entry name" value="Nuclear cap-binding protein subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027157">
        <property type="entry name" value="NCBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034148">
        <property type="entry name" value="NCBP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847">
        <property type="entry name" value="20 KD NUCLEAR CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="34"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="124"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW86006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="218" mass="24681" checksum="216D439EC672A2F2" modified="2014-03-19" version="1">MSSVVSPLDQPSNYKDSQSRVDRQKQHDYLSKSSTLYIGNLSFYTTEEQIYDIFTKCASPEDGGGVKRIIMGLDRHTRTPCGFCFVEFYTHAEALASMRYISGTKLDERIIRCDLDLGYRDGRQFGRGKSGGQVRDEHRQDYDPGRGGWGAQAQRLEIERRREVEERYADTEQGGPVAGGGEDWKDQNPAAPTLKRGRSPEDEGDNDRQVSPNCPRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KM43</accession>
    <name>W4KM43_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ICE2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_306512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540847.1">
        <property type="nucleotide sequence ID" value="XM_009542552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KM43"/>
    <dbReference type="FunCoup" id="W4KM43">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KM43"/>
    <dbReference type="GeneID" id="20669411"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_306512"/>
    <dbReference type="eggNOG" id="ENOG502QRTT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027878_0_0_1"/>
    <dbReference type="InParanoid" id="W4KM43"/>
    <dbReference type="OrthoDB" id="5577218at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048309">
        <property type="term" value="P:endoplasmic reticulum inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013635">
        <property type="entry name" value="Ice2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31726">
        <property type="entry name" value="PROTEIN ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31726:SF2">
        <property type="entry name" value="PROTEIN ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08426">
        <property type="entry name" value="ICE2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="40223" checksum="D5DE71220213BA1F" modified="2014-03-19" version="1">MQGPWFLWSALTSTAKLSNFLQVLIFLPLTLSTLSKSAFLLLSLLIFLQSLIHGTLQLLWGSPVLPVMQLPIQPFLLLVCFNIFSESVHPLLLNLASWWGTILTYSSPLFIIFEAMSSLLVSQKLGQVGRELVGEGEAYQFGLLIAAAAAYVVSAWWIVVAYPAAALSPLSSTLLGVALTAFLFLTFIGFVLRRTNVIESSGLALFIAYNIWLCGFDQQSFTDLGSTYVPLVGNIVPHLQTLVNFIMNTLPKPVLIALIYRVAILLCAARILPTIGADSWETEYGVDDGWDGRPTSRLTKILLTYRQSILVTVYTHLLLLDHSSQVWWRWMNIFFTLFIWSIELLVSAEDDAITKEWKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>W4KN53</accession>
    <name>W4KN53_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_468443</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540774.1">
        <property type="nucleotide sequence ID" value="XM_009542479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KN53"/>
    <dbReference type="STRING" id="747525.W4KN53"/>
    <dbReference type="GeneID" id="20677234"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_468443"/>
    <dbReference type="eggNOG" id="KOG1973">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006204_2_0_1"/>
    <dbReference type="InParanoid" id="W4KN53"/>
    <dbReference type="OrthoDB" id="2505961at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16859">
        <property type="entry name" value="ING_ING4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF42">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="339"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="142"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="387"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="387"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW86790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="418" mass="44870" checksum="AE58BB87B0A525EB" modified="2014-03-19" version="1">MPMTSDTVALTAAYSLSLLSEYTHTLDTLPLDLSKQFADLRELDAVLSASMHTITAKVNRLIDMIEHDTQPKESRLWLLAEIAEEAQRLKLGGEDKIRVASQAADGLKGHHDHLANLLQHIPNFDTSVLQRKTVYPHVAPRSYAPTSMYEGGRRRRGALLNGSSGDQTPAKKRRIARDDDIEGSVSRTPRGDRVGDSSAPQRPKNGSRARKNDRMPSPAESVLSVISHQPPQSLPVSRITSRLVPTNRRARPSVDPSAPKDIPNAPPAASHPSLPPPYAPVSTFSGPGWSGPVHAQLQGPGMPVARNVVPTSAILIGPGVEGTAHIQSGGEGEEADDGKLYCWCNGPSHGVMIACDDAECEKEWFHLGCIGLEVLPKGAWYCDTCKGKKKNQRGGRGTKRRSGGARSGARVASAASTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNJ0</accession>
    <name>W4KNJ0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_406590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540624.1">
        <property type="nucleotide sequence ID" value="XM_009542329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNJ0"/>
    <dbReference type="GeneID" id="20672529"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_406590"/>
    <dbReference type="HOGENOM" id="CLU_862083_0_0_1"/>
    <dbReference type="InParanoid" id="W4KNJ0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="323" mass="31483" checksum="4421D85679EF5949" modified="2014-03-19" version="1" fragment="single">MTPANAASQSTDVTTAASSPVVDANQSQEQVKDSSMSTSSISKPIGKAAPVSEDINGGLAASIHATASVESVSGVSASMWATAPAAPPSLASRSGLSASMWATAPKASSSLASRSGLSASMWATAPAASPSLALGNGSSASMWATAPKASPSLALGNGSSASMWATAPKASSLASGNGSSASMWATAPEPSSSRTSNSGLSASIWATSSPASSSRASTTASARGSNRYRGSSAVPKGPNSSRKPNVARQSHKPTARPSSTAAPIASGSKPPRSSFGLGASIHAPQATRAAPFEFGSAQQAPASSVVNGLAALASVAQDLVPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNX2</accession>
    <name>W4KNX2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_413702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541300.1">
        <property type="nucleotide sequence ID" value="XM_009543005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNX2"/>
    <dbReference type="STRING" id="747525.W4KNX2"/>
    <dbReference type="GeneID" id="20673125"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_413702"/>
    <dbReference type="eggNOG" id="ENOG502RVKY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_868946_0_0_1"/>
    <dbReference type="InParanoid" id="W4KNX2"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="320" mass="34078" checksum="0A04585EB726A94F" modified="2014-03-19" version="1">MAHSEEDRSRGGDRGPGGGPCLLCSPAAARQTGPLPPSTPTQHASTAQTRPSPRVPAHTSTPMADDTRSRARKIHRPIFIVANPGSGEDDDGEQAQAYAPRAQKHPYNPQPSPTLTSPPPDRAIHPSASSSSHRDPGPLTTTNLPSHSRHHPASRSNPTLSSPSGTSSPPPTTPGQSAPPGDLVADAAARHDFAPSYSTDALHQQHSSHSISNKSTFLDKMKANIHHPFAHGRRLSSSSRPTTSPTTSTSDTYATRFPNDSSRSSPLDKVLIFVTGDSDQYYTVDITGFRHGAFIKELVFSKVRRLSSSSRPASRPARLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPC5</accession>
    <name>W4KPC5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_406952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPC5"/>
    <dbReference type="STRING" id="747525.W4KPC5"/>
    <dbReference type="GeneID" id="20672559"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_406952"/>
    <dbReference type="eggNOG" id="ENOG502R0UV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1212284_0_0_1"/>
    <dbReference type="InParanoid" id="W4KPC5"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW87240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="229" mass="25382" checksum="4C5B5EC84C9A8FA0" modified="2014-03-19" version="1" fragment="single">MSPTPILPYPINLILHYISPPSQLNDTITPHILSRSLLQRHRFLGITPDDPANYLCWPSSNRDRTMNLLESLPKSLDDPSSSDLRVQYLSDIEHTYAHAHVSSTNESDGLRLVFQWEPSDNSWKYHDAGLMPFPSTSCPSLKDALAMTGVSDRIPSEANLISHATPGESDEDDYWNSYASRADNDDTELDGHLVARHSGSEVGDDAYWAQYASVQGSADSTIPSPVVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPT1</accession>
    <name>W4KPT1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aspartic peptidase DDI1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_40460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009542011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPT1"/>
    <dbReference type="STRING" id="747525.W4KPT1"/>
    <dbReference type="GeneID" id="20672514"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_40460"/>
    <dbReference type="eggNOG" id="ENOG502SRIE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003921_0_0_1"/>
    <dbReference type="InParanoid" id="W4KPT1"/>
    <dbReference type="OrthoDB" id="3252634at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW87797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="32595" checksum="F9BFD083CE38A9E5" modified="2014-03-19" version="1">MGAPAKIPSAKKDAPAYKTTAPIYDEKVAAEVYNRAMATQVTLTQRELLSLSAEVRSQVREATSARQSPARDASNVRTFYQDADLPYAIDNLEPPTRPTVSSFVNVLHQPETPPPGAIIIPDMYETYLKNLQPGQVPQPLIVAKESSALRSIVPLVDHQQEVECVIDPGSQVIAMSEGICNELALIYDPEIVLNMQSANGEIDRSLGLARNVPFLIGDITLYLQVHIIRNPAYDVLLGRPFDILTESIVKNYSNEDQTITISDPNTGRRATIPTIRRGPPRVLHRRQAGFRDSMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KQA0</accession>
    <name>W4KQA0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_378035</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541159.1">
        <property type="nucleotide sequence ID" value="XM_009542864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KQA0"/>
    <dbReference type="STRING" id="747525.W4KQA0"/>
    <dbReference type="GeneID" id="20671912"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_378035"/>
    <dbReference type="eggNOG" id="KOG4640">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_279131_0_0_1"/>
    <dbReference type="InParanoid" id="W4KQA0"/>
    <dbReference type="OrthoDB" id="10259843at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024789">
        <property type="entry name" value="APC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024790">
        <property type="entry name" value="APC4_long_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12896">
        <property type="entry name" value="ANAPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="643"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="761"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="828"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="899"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="987"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="662"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="836"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1027"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1099"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW87231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1099" mass="120916" checksum="8C211F8C1AC9C94A" modified="2014-03-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4KQM6</accession>
    <name>W4KQM6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_378867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541574.1">
        <property type="nucleotide sequence ID" value="XM_009543279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KQM6"/>
    <dbReference type="STRING" id="747525.W4KQM6"/>
    <dbReference type="GeneID" id="20671939"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_378867"/>
    <dbReference type="eggNOG" id="ENOG502SMEF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022554_0_0_1"/>
    <dbReference type="InParanoid" id="W4KQM6"/>
    <dbReference type="OrthoDB" id="21648at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="698"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="708"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="731"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="750" mass="80604" checksum="8B466AFD6FE1B2FF" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KR29</accession>
    <name>W4KR29_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_437936</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
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        <property type="protein sequence ID" value="ETW87850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541707.1">
        <property type="nucleotide sequence ID" value="XM_009543412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KR29"/>
    <dbReference type="FunCoup" id="W4KR29">
        <property type="interactions" value="562"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KR29"/>
    <dbReference type="GeneID" id="20674997"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_437936"/>
    <dbReference type="eggNOG" id="KOG3949">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031345_1_0_1"/>
    <dbReference type="InParanoid" id="W4KR29"/>
    <dbReference type="OrthoDB" id="289162at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19494">
        <property type="entry name" value="Elp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PAX6 NEIGHBOR PROTEIN PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="412"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="412"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW87850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="486" mass="51391" checksum="20D17E3730B62909" modified="2014-03-19" version="1">MSSFKRKAATKQSTLPPGCRISPSSPSTVITSTGIPSLDDILGGGLPLSCSLLVLAPDPHSAYGELVQKYFIAQGLACGQTVCVIDDDAEAFVAECMWTPSASAPFSHAPAQVADDERAEDATGEDAQIKIAWRYERMGKFQTTVGPSSTSTSTSPSSTASNPSSDEFCRTFDLTCRVPRVVLEAAMGASRVRPIPVSVSASDADASERPGTLAGPRIAHLVHTLSALLEASCSPMSPVRICVPALGSPQWGDLEAQDILRFLHSLRALLRRHPSACAAIALPPDISADGWGGPGWVQKLGWLSDASITLAAFTADPALSAMFPAHHGLLHIHGLPAPHTLLPPSDRFSTLRGIALASGASGGGENNLAFKCMRKRLVFETLHLDVEGGVGERRTTPAARAAALDEALVHGHDHDHDHDHRGHAHAEGPAAESQAERAAGARVEVKFEEAKKESEAGEGDQPQGRAKAKAKKKVAFRTDRPDLYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JN38</accession>
    <name>W4JN38_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_331786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553411.1">
        <property type="nucleotide sequence ID" value="XM_009555116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JN38"/>
    <dbReference type="GeneID" id="20671681"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_331786"/>
    <dbReference type="eggNOG" id="ENOG502SYFS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181169_0_0_1"/>
    <dbReference type="InParanoid" id="W4JN38"/>
    <dbReference type="OrthoDB" id="2741553at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW74953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="93" mass="10154" checksum="DFFBEE1AF699BBD8" modified="2014-03-19" version="1" fragment="single">CSACLRWGHARPVCHSITCRCNHCGGNHLEQEHHQRAACCQGGNPTPGNAPCPHPPKCVNCGAAHKATERTCPFYGHRHDCDWISQHQPHAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNH9</accession>
    <name>W4JNH9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_455797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552550.1">
        <property type="nucleotide sequence ID" value="XM_009554255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNH9"/>
    <dbReference type="GeneID" id="20676664"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_455797"/>
    <dbReference type="HOGENOM" id="CLU_702187_0_0_1"/>
    <dbReference type="InParanoid" id="W4JNH9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="393" mass="41967" checksum="4E4B339BCF9A8EB9" modified="2014-03-19" version="1">MRGTSLALVSPLSRPTLSNQSPALLLSPLSLLSLLDVIPTGPLARSPASSTPPRALSAFPGSSLDTPASPTRRHSQLLTPLSYCGLEPLLRHASPRPPPRLRAHSALCMRTPSTFVCIPSAVNIPALDVAHPRRLAPPVPSFSSNVNRPLDSIRSRSLSPASCHLQPRALVPSDAHTASTRRPPPHLTNPLVLVASTISVRTLGTLQAYYLEPLNSAPSTSPLSRAERRGRSIDAFARALAQDAPSLRPFKREQRGRDSPGGRERGWMRTMDGGGGQTWVGMDDDNLTCSSRSPSTFDTKTPDIQGSTVDESCMVQKRPRAVCGSQAPHSPNSPKVNSGFVGSLAAADSTRPPPSPAPFPSFFLFLSSPLVFLMLTFDITNSLLGRTSSNTIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNM3</accession>
    <name>W4JNM3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_461406</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553160.1">
        <property type="nucleotide sequence ID" value="XM_009554865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNM3"/>
    <dbReference type="STRING" id="747525.W4JNM3"/>
    <dbReference type="GeneID" id="20677165"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_461406"/>
    <dbReference type="eggNOG" id="ENOG502RZTS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_415633_0_0_1"/>
    <dbReference type="InParanoid" id="W4JNM3"/>
    <dbReference type="OrthoDB" id="2384193at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844906" evidence="3">
        <location>
            <begin position="22"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW74665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="660" mass="71054" checksum="19433643E204FCCA" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNS6</accession>
    <name>W4JNS6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_455862</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552633.1">
        <property type="nucleotide sequence ID" value="XM_009554338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNS6"/>
    <dbReference type="STRING" id="747525.W4JNS6"/>
    <dbReference type="GeneID" id="20676673"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_455862"/>
    <dbReference type="eggNOG" id="KOG0123">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1310289_0_0_1"/>
    <dbReference type="InParanoid" id="W4JNS6"/>
    <dbReference type="OrthoDB" id="407442at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15241:SF304">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15241">
        <property type="entry name" value="TRANSFORMER-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="101"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW75193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="210" mass="23482" checksum="E415E60131AAD881" modified="2014-03-19" version="1">MSIAISWPWIIVDPKEQVDKDCMHIFEKMTDTQGMHNGYGFMRFDVAQTAELLHRLVYTVVPSDSAKIPKSHRVGAKVARRLIHAEQDRQVLKDAVKSEFTTVFVGGLDPNVTRDELRASFKQYGRITSINIPRDPESGSGKGFGFVKFLEHADALEAVKGANGTVLKGQLLKVSPSQKKEDRQASLAVGYTQAREDIRKKDTKQAKRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNV2</accession>
    <name>W4JNV2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_243345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552609.1">
        <property type="nucleotide sequence ID" value="XM_009554314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNV2"/>
    <dbReference type="STRING" id="747525.W4JNV2"/>
    <dbReference type="GeneID" id="20668979"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_243345"/>
    <dbReference type="eggNOG" id="ENOG502SSUT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114638_0_0_1"/>
    <dbReference type="InParanoid" id="W4JNV2"/>
    <dbReference type="OrthoDB" id="2500073at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="121" mass="12924" checksum="1282ABC4270291DC" modified="2014-03-19" version="1" fragment="single">DDYPPQRHAGAVGYGPAYGKGPGLGEKITGIKEQIKGKLSHNPQLVEQGQLRKTGELKKRQQEDKDPFQDPISGSQPAQASGNKPSDNVTSSAPHERASTVAPRGTDAAEEQRGEGRNVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQ23</accession>
    <name>W4JQ23_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_412081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551901.1">
        <property type="nucleotide sequence ID" value="XM_009553606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQ23"/>
    <dbReference type="GeneID" id="20672995"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_412081"/>
    <dbReference type="HOGENOM" id="CLU_1845352_0_0_1"/>
    <dbReference type="InParanoid" id="W4JQ23"/>
    <dbReference type="OrthoDB" id="3068102at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="145" mass="16250" checksum="F873AA0B0020CDF5" modified="2014-03-19" version="1">MPRMSVFDARLQQQLRTANIGRSVQARHDILAKSPIESSRAAAHAIREGELEHAIELLEHGRSVVWQQTLRLRPSTDKLHQVSPALAGRLSKTLGELDGMNVEPLAPGVRPSDWRRRQTRRVQRHPPSSSSSWTLSMPSGPTTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQ52</accession>
    <name>W4JQ52_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Extracellular metalloproteinase</fullName>
            <ecNumber evidence="12">3.4.24.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Fungalysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_436715</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase M36 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="12"/>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551928.1">
        <property type="nucleotide sequence ID" value="XM_009553633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQ52"/>
    <dbReference type="GeneID" id="20674906"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_436715"/>
    <dbReference type="eggNOG" id="ENOG502SIXN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012703_4_2_1"/>
    <dbReference type="InParanoid" id="W4JQ52"/>
    <dbReference type="OrthoDB" id="3227768at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09596">
        <property type="entry name" value="M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050371">
        <property type="entry name" value="Fungal_virulence_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001842">
        <property type="entry name" value="Peptidase_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478:SF1">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02128">
        <property type="entry name" value="Peptidase_M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00999">
        <property type="entry name" value="FUNGALYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="7 11 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009369531" description="Extracellular metalloproteinase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW75663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="598" mass="63748" checksum="F1440AA2E75102CC" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W4JR22</accession>
    <name>W4JR22_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_446925</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552747.1">
        <property type="nucleotide sequence ID" value="XM_009554452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JR22"/>
    <dbReference type="FunCoup" id="W4JR22">
        <property type="interactions" value="641"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JR22"/>
    <dbReference type="GeneID" id="20675720"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_446925"/>
    <dbReference type="eggNOG" id="KOG0417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_13_2_1"/>
    <dbReference type="InParanoid" id="W4JR22"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23813">
        <property type="entry name" value="UBCc_UBE2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000020">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW75316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="149" mass="17121" checksum="8C763F6A18F4F3BE" modified="2014-03-19" version="1">MSLPKRIIKETERLVADPAPGITAFPHDDNLRYFDVTIQGPDGSPFQHGVFKLELFLPEEYPMAPPKVRFLTKIYHPNIDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDPLATDVAKHYKEDERDAQRISREWTERYAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4JR59</accession>
    <name>W4JR59_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_162817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552280.1">
        <property type="nucleotide sequence ID" value="XM_009553985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JR59"/>
    <dbReference type="GeneID" id="20667796"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_162817"/>
    <dbReference type="HOGENOM" id="CLU_2886079_0_0_1"/>
    <dbReference type="InParanoid" id="W4JR59"/>
    <dbReference type="OrthoDB" id="1045822at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="63" mass="6667" checksum="88B822551E31E0E8" modified="2014-03-19" version="1">MPASHSPILRLTSVALSVSNLQILAASLSIDGKLCDVDVTLSFILLDVSMAFTVCSVIDGQCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4JR91</accession>
    <name>W4JR91_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Quinone oxidoreductase 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">qor14</name>
        <name evidence="2" type="ORF">HETIRDRAFT_108043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552807.1">
        <property type="nucleotide sequence ID" value="XM_009554512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JR91"/>
    <dbReference type="STRING" id="747525.W4JR91"/>
    <dbReference type="GeneID" id="20666304"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_108043"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_1_1"/>
    <dbReference type="InParanoid" id="W4JR91"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF5">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="19"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="393" mass="43269" checksum="0BA463B2D15D6365" modified="2014-03-19" version="1">MSSTPMKKLPTRHKAIVVARSGYVDLEEVDMPKLGTNQILVQVGAAAQSSCDWQTMVYAKKYGAVAGCNFAGTVVQIGPDVPENQWTVGDRVAGFVHGGGWFTRSPRPLRFNYDCPLGLISNGSFAEYVVAFAHIAVHIPSSWSLEDASQLGIAPFTACQYLYHIHNFHIPSELKDLPAKPDDEREMLLVYGGATSVGLYTIQLAKLSGLRVFAACAPRHFELLRDYGADEVFDYTNPQVSMRIGMNTYGKLKYAVDIVSERQSPYQVSRSLSREGGKVSSCKKYASPRPGVEVHWTFPFMLLPENCDYPAPYTSKEEERDRGQKYAQLISNVIANGSVKPIPALILPDGLASVAQGLEMMMEGNTVGTTVTYRISDTPDIRIEAKDDVLMPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRB7</accession>
    <name>W4JRB7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_108021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552831.1">
        <property type="nucleotide sequence ID" value="XM_009554536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRB7"/>
    <dbReference type="GeneID" id="20666298"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_108021"/>
    <dbReference type="HOGENOM" id="CLU_1008514_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRB7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="276" mass="29558" checksum="43966A05C217AFD7" modified="2014-03-19" version="1">MPPRRRARSPPQAISRVLPSCGCKAVGRACSIVSRTLALAAPTPSPSALLNPSLWPDVAVSPGQDSLKPRAPGICLQCHQGAAAELLGRTTCNVPRTTHTLMARAQISGAGCTVRGAPEQSSVCGPPLRKKNAFRGGFERINWGAGAEDEFQSPDSRCPRGPVRPAAIVPSFRALRLPCGAISLCEAPPRCRLRGRSKGKVQNRGDGGELAWAGAAPEASRITARETARKFVWRAHGPDRHRCMVPDGRFYWRNGGRRTTERPSPLKDRTLGGLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRD4</accession>
    <name>W4JRD4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_329914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552349.1">
        <property type="nucleotide sequence ID" value="XM_009554054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRD4"/>
    <dbReference type="STRING" id="747525.W4JRD4"/>
    <dbReference type="GeneID" id="20671534"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_329914"/>
    <dbReference type="eggNOG" id="ENOG502SNMY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047592_2_1_1"/>
    <dbReference type="InParanoid" id="W4JRD4"/>
    <dbReference type="OrthoDB" id="9997739at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="20"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="249" mass="28050" checksum="0F88EAC399A53DC2" modified="2014-03-19" version="1">MAHLTTPSAMRLHDYYLQGGDIVFRVENFLFRIHSYFFVRESPYFREKLPHPSPPGSISYLTSDDNPFVLDGVSSTDFQRFLWVFYNPELSIYNASIEEWESILRLAHLWQFHKVKALAVRHLENIPMDAVQRVVLYVKNDVDESLLIPPYAELTIRESPISLQEGRQLGIVTALRLAQAREIARSPQSPKGHRITSPVSAVGPDLDSLIKNVFEVSTRAQGADEGAADGSSTATEISQGQSMMITLCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRG7</accession>
    <name>W4JRG7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_412283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552282.1">
        <property type="nucleotide sequence ID" value="XM_009553987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRG7"/>
    <dbReference type="GeneID" id="20673014"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_412283"/>
    <dbReference type="HOGENOM" id="CLU_1820390_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRG7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="142" mass="15688" checksum="A8B8AB07D5B5F80E" modified="2014-03-19" version="1" fragment="single">MDSYAAYSMSANGANDHFRNILEPRGLGLHNVRSFSSRDIKNFAFIDPPRQIFVFFDNDKGVDVLLDMDPTSSTDGPGPVVCIRYKDLPNTAILNPPLFFFGESGSVGIAYADAIDGRYASLRMGQEALGWDKKDLLLHIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRJ3</accession>
    <name>W4JRJ3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_330167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552305.1">
        <property type="nucleotide sequence ID" value="XM_009554010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRJ3"/>
    <dbReference type="GeneID" id="20671555"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_330167"/>
    <dbReference type="HOGENOM" id="CLU_2812692_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRJ3"/>
    <dbReference type="OrthoDB" id="586585at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="67" mass="7781" checksum="5AB65916A9FA9D92" modified="2014-03-19" version="1">MCFRLVSALREGAGAGCRASIYDSRERPSYRIRARRRQLCLWGERRAVCSVFLRSLSPIVLYFHDCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4JS36</accession>
    <name>W4JS36_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_327993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551286.1">
        <property type="nucleotide sequence ID" value="XM_009552991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JS36"/>
    <dbReference type="STRING" id="747525.W4JS36"/>
    <dbReference type="GeneID" id="20671381"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_327993"/>
    <dbReference type="eggNOG" id="ENOG502S89B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074184_1_0_1"/>
    <dbReference type="InParanoid" id="W4JS36"/>
    <dbReference type="OrthoDB" id="4850648at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37827:SF1">
        <property type="entry name" value="HNH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37827">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="25120" checksum="E0457AD3BD9E60F3" modified="2014-03-19" version="1">MVSSTQYQFFKDCLARRIISQSIPTDSNEDTSQLNEFSSFLSLEVWPCLPSSICEVSFETRERLPDLDAITLDNIPVPFSDSLILYGLCDDWDAAREFLRKVLLDYVKEACAPPPVWSATRTIECEMCEREIPLTYHHLIPRSTHTKVLKKRWHPESMLNAVAWLCRPCHNAVHHVATNEELARRFYTMQLLLERDDLQRWRQYAAKQRFGVKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSE2</accession>
    <name>W4JSE2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription and mRNA export factor SUS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">SUS1</name>
        <name evidence="2" type="ORF">HETIRDRAFT_53245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex required for deubiquitination of H2B and for the maintenance of steady-state H3 methylation levels. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. May also be involved in cytoplasmic mRNA decay by interaction with components of P-bodies.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least SUS1, SAC3, THP1, SEM1, and CDC31. TREX-2 contains 2 SUS1 chains. The TREX-2 complex interacts with the nucleoporin NUP1. Component of the 1.8 MDa SAGA transcription coactivator-HAT complex. SAGA is built of 5 distinct domains with specialized functions. Within the SAGA complex, SUS1, SGF11, SGF73 and UBP8 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with THP1, SAC3, SGF11, and with the RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ENY2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551172.1">
        <property type="nucleotide sequence ID" value="XM_009552877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSE2"/>
    <dbReference type="FunCoup" id="W4JSE2">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JSE2"/>
    <dbReference type="GeneID" id="20678246"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_53245"/>
    <dbReference type="eggNOG" id="ENOG502SDC3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134052_2_0_1"/>
    <dbReference type="InParanoid" id="W4JSE2"/>
    <dbReference type="OrthoDB" id="6221744at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071819">
        <property type="term" value="C:DUBm complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03046">
        <property type="entry name" value="ENY2_Sus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018783">
        <property type="entry name" value="TF_ENY2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038212">
        <property type="entry name" value="TF_EnY2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12514">
        <property type="entry name" value="ENHANCER OF YELLOW 2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10163">
        <property type="entry name" value="EnY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0010">Activator</keyword>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="99" mass="11508" checksum="EB7177F6B70C5B0D" modified="2014-03-19" version="1">MPATTQSEIDTLYSQVHRRLVDSGEWDRISLSLKYKLNDEGWIDQLRGKSKEQARVMEPLSLRQLLELVEPSAQASVPETVKHQTLVLIRQFLEKQFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JST4</accession>
    <name>W4JST4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_455143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
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        </citation>
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            <end position="243"/>
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        </location>
    </feature>
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    </feature>
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            <end position="56"/>
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            <end position="132"/>
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</entry>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
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                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Duplessis S."/>
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                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
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                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
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    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
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                <person name="Fossdal C.G."/>
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                <person name="James T.Y."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
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    <gene>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
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                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
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                <person name="Henrissat B."/>
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                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551757.1">
        <property type="nucleotide sequence ID" value="XM_009553462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTN1"/>
    <dbReference type="GeneID" id="20666148"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_106271"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_0_1"/>
    <dbReference type="InParanoid" id="W4JTN1"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="9">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW76893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="511" mass="55872" checksum="ABFFEFCF93064745" modified="2014-03-19" version="1">MPIVQADDISGKTFDYIIVGTAGLVVAARLSEDPNVSVLVLEAGPANIDDALLCRPASIGATFGQEQYDWSFKTVPQTHSNNKEYFWFSGRTLGGSSAVNFFAWNKPPADHIDDLERLGNPGWNWANLQKYIARAEGFVPPTPEEIKEHELIGAENWKLREKGPIDLAIPKRFLSGDLDAVHTVLNAGIPRAAAPLAGLSFAPSTINPVTFSRSFATTGYWLPNQNRHNLSLIVNATATKIITEGESPSLEATGVQFVIKGANNVHKVVHAGKEVILSAGSIKTPHLLELSGIGDEKILDKVGIPVKIDLPGVGENVQEHCIISITFELRDDVSYEIFDVLPDPARAAKELKLYTSLPKIPWRSLPLTHTTLRKTSVRGPSLQFSWRAMLASEADLRTFVVDVKFIRKLPTLSPHKEVIVKEINPSPTVTTDEQIGDWIKNYMSTTFHTAGSASMPPKDKDGVVDPRLKVYGTSNLRVVDLSVVPLLFTAHSQSVVYELAKQAAAIIKGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JV02</accession>
    <name>W4JV02_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_454702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550904.1">
        <property type="nucleotide sequence ID" value="XM_009552609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JV02"/>
    <dbReference type="GeneID" id="20676544"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_454702"/>
    <dbReference type="HOGENOM" id="CLU_2073464_0_0_1"/>
    <dbReference type="InParanoid" id="W4JV02"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="118" mass="12401" checksum="D63DA47912FA6BB8" modified="2014-03-19" version="1">MPDIDASYSVGHAHSGSSDFEGDLKELRATANGCPRGRGHSPVPIRAPRDDERGTSGARAVTSALPFNPPALHTTSTRSDAHRTRVPGSSTIRLEAAVPRASVDALQLRSLPIATLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4JW12</accession>
    <name>W4JW12_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_324841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549783.1">
        <property type="nucleotide sequence ID" value="XM_009551488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JW12"/>
    <dbReference type="GeneID" id="20671088"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_324841"/>
    <dbReference type="HOGENOM" id="CLU_2527737_0_0_1"/>
    <dbReference type="InParanoid" id="W4JW12"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="84" mass="9486" checksum="6BFE822884F53AC6" modified="2014-03-19" version="1">MLASLCRAPFSPPRQVCNSDRIPKRSDSVLSHISPSALQRASLPRKKRHHISVRPMPNAQNLWSPEPEHGHLSVLHPHFSRISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWK7</accession>
    <name>W4JWK7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450 monooxygenase 29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">cyp29</name>
        <name evidence="12" type="ORF">HETIRDRAFT_65589</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550527.1">
        <property type="nucleotide sequence ID" value="XM_009552232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWK7"/>
    <dbReference type="GeneID" id="20678744"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_65589"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_1_1"/>
    <dbReference type="InParanoid" id="W4JWK7"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF4">
        <property type="entry name" value="CYTOCHROME P450 98A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW77266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="525" mass="59937" checksum="4FF25E6C95451327" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWM0</accession>
    <name>W4JWM0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_107489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549865.1">
        <property type="nucleotide sequence ID" value="XM_009551570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWM0"/>
    <dbReference type="GeneID" id="20666250"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_107489"/>
    <dbReference type="HOGENOM" id="CLU_1250813_0_0_1"/>
    <dbReference type="InParanoid" id="W4JWM0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="221" mass="24237" checksum="EB39E38F7FF9E500" modified="2014-03-19" version="1">MMPVHGPLMTPDIREVSNAQVTTKRLKVEQRLISQRHELPYLGAWDAVAPFIRRLPPTQLFATSSRLLYGLRAGRRKKVEGEGHGVGGACDRLATLSTTTLQEKHLLPNWIALQLAMANRSEDVGKRRDSQGFSRHASTMSSERLCSSPAKHEGHDASFCIGCTVVDGLRSAVHTGGDDERRGRSLLTIVRDGRNQMPWLSVRPSPSAAPERLCCAAPAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWV2</accession>
    <name>W4JWV2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Domain of unknown function at the cortex 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_411233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550041.1">
        <property type="nucleotide sequence ID" value="XM_009551746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWV2"/>
    <dbReference type="STRING" id="747525.W4JWV2"/>
    <dbReference type="GeneID" id="20672934"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_411233"/>
    <dbReference type="eggNOG" id="ENOG502RXNE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047849_1_1_1"/>
    <dbReference type="InParanoid" id="W4JWV2"/>
    <dbReference type="OrthoDB" id="2119945at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013897">
        <property type="entry name" value="Duc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826:SF2">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08588">
        <property type="entry name" value="Duc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function at the cortex 1" evidence="2">
        <location>
            <begin position="3"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW78037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="355" mass="38872" checksum="126724044EC4ECF5" modified="2014-03-19" version="1">MPRLRVLAGPTPTTLTPISANCSTPHIISTPDFEGRVLVYIKGLNDSNSTVPENEYFSRDDRKGITWSIQVQGRFLQPRSADDVLFGNTFDRPLKLPWGSSVALKFMSIVDPTLEHDLASPTKPWALSPLIATMPHFAHARLKGDSEWPDLASASSLVDDISQLYLAVNSRPALTTSSSSSSSSSSSSLLTSSSSLSPSSTSSSPNFVQLEAGKSSPLSSHAHMQSDKNKNTEEHRKKRGKQSKSLERILSALSTADKRRKHFASSAHRQAIVFGPHDLLTTDFCYGFLEFSPSLALRLPGGVSFDLMHYWDGQPVRFVCCERAKTQNGDPIEGEGDPWGKVFWCVTIELEEGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4JX12</accession>
    <name>W4JX12_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_446319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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                <person name="Asiegbu F."/>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <sequence length="763" mass="85109" checksum="FE17AAFA208366EB" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXH9</accession>
    <name>W4JXH9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_389182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551078.1">
        <property type="nucleotide sequence ID" value="XM_009552783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXH9"/>
    <dbReference type="GeneID" id="20672395"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_389182"/>
    <dbReference type="HOGENOM" id="CLU_2740338_0_0_1"/>
    <dbReference type="InParanoid" id="W4JXH9"/>
    <dbReference type="OrthoDB" id="2566866at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="71" mass="8093" checksum="671E4D83355A7949" modified="2014-03-19" version="1">MAAYIPKLFSFDEEQGQLNNTTANFSRQRLRRSTNRIFPRLLVIVVVVAIIIRISLHFVNGHRGVIKSVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXL0</accession>
    <name>W4JXL0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_326088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550206.1">
        <property type="nucleotide sequence ID" value="XM_009551911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXL0"/>
    <dbReference type="STRING" id="747525.W4JXL0"/>
    <dbReference type="GeneID" id="20671206"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_326088"/>
    <dbReference type="eggNOG" id="ENOG502S808">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056788_1_0_1"/>
    <dbReference type="InParanoid" id="W4JXL0"/>
    <dbReference type="OrthoDB" id="2142724at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047655">
        <property type="entry name" value="Transpos_IS630-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033545">
        <property type="entry name" value="transpos_IS630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="68"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="238" mass="27279" checksum="CE7064D984BCD7D2" modified="2014-03-19" version="1" fragment="single">PCAYLDEMQDALQKEFGLETSTTTLLAVVRALDYTNKHVSKCALERDDSQCAVFWYVIGKIAPDPNMLVFLDEASKNEKTPGQLKGWLLRGTRVYQRWCFIHGKWYSILPAITLNGIVAREIVDGLVTTKQFCDFLRYYVIPLTNPYPGPRSCIVLDNCSIHHSEEVRKIIEDEAECKMIFLPSYSPDYNPIKLAFSAIKAYLCCHYEDSCLMTIHDACDSIGPWKALEWFRICGYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXU0</accession>
    <name>W4JXU0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_325778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550326.1">
        <property type="nucleotide sequence ID" value="XM_009552031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXU0"/>
    <dbReference type="GeneID" id="20671177"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_325778"/>
    <dbReference type="HOGENOM" id="CLU_2365242_0_0_1"/>
    <dbReference type="InParanoid" id="W4JXU0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="96" mass="10396" checksum="059788DFDF854157" modified="2014-03-19" version="1" fragment="single">YASPGQYGESARNNTPPSLGRVEARRYGYLQGAGVVATPIYGADPYAPYQIMAHYTYYGLPLLFRRLSFATDGPHGITAAIRCHSGSCGQCDSFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4JY33</accession>
    <name>W4JY33_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_454077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550015.1">
        <property type="nucleotide sequence ID" value="XM_009551720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JY33"/>
    <dbReference type="GeneID" id="20676463"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_454077"/>
    <dbReference type="eggNOG" id="ENOG502SN1K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_331765_0_0_1"/>
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            <begin position="134"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="235" mass="25703" checksum="C5826D0F57E88014" modified="2014-03-19" version="1">MASTIEIASAKRSLPLCSPHLMPFKISHSGPAPVSTYFRVKPTTVSLPLPPNIPSAQSNPHDENETTDPNFMEIDTTPLNQANELPDDGQPIPGPSQSAAKRFTSAFRGRAMQGLTVDLPQGYTGIVLRGDSSKFGTTQRTKTKEKWNGRGRTSGKQKTAKAAQEVDDNAEELHGEAEGTVDGDEDAIRVLRPTAKFDSFVLWHPDIPVDEGKDEYLRSLNEWIGLAAEIHKIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYZ9</accession>
    <name>W4JYZ9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_421044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550271.1">
        <property type="nucleotide sequence ID" value="XM_009551976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYZ9"/>
    <dbReference type="GeneID" id="20673696"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_421044"/>
    <dbReference type="eggNOG" id="ENOG502S3VE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170506_0_0_1"/>
    <dbReference type="InParanoid" id="W4JYZ9"/>
    <dbReference type="OrthoDB" id="4381806at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="103" mass="11945" checksum="36E8A815205DE2B7" modified="2014-03-19" version="1">MEPFSTSVFKFIRQVSCYTLLSGFRLPWPPSCCLDELTPFVVSDERVFRHLNLAFGSSRIASSAYQKWPTRNSQSPSGPIKRRLVLTYLKFENRLRLFQPQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZS9</accession>
    <name>W4JZS9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_441128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549264.1">
        <property type="nucleotide sequence ID" value="XM_009550969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZS9"/>
    <dbReference type="GeneID" id="20675330"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_441128"/>
    <dbReference type="HOGENOM" id="CLU_2740336_0_0_1"/>
    <dbReference type="InParanoid" id="W4JZS9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="71" mass="7856" checksum="57CEE753A3143DE8" modified="2014-03-19" version="1">MADSAGIKSEFGAHGLREERGNYYPLPKNCSTSQPAHGAFAFAPCSFQLASFFSFPSLNKNERPVPTDRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W4K087</accession>
    <name>W4K087_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WDR5-like beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_478647</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549485.1">
        <property type="nucleotide sequence ID" value="XM_009551190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K087"/>
    <dbReference type="STRING" id="747525.W4K087"/>
    <dbReference type="GeneID" id="20677832"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_478647"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_1_1"/>
    <dbReference type="InParanoid" id="W4K087"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035097">
        <property type="term" value="C:histone methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000228">
        <property type="entry name" value="COMPASS-like H3K4 histone methylase component WDR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059122">
        <property type="entry name" value="Beta-prop_WDR5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25175">
        <property type="entry name" value="Beta-prop_WDR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR5-like beta-propeller" evidence="5">
        <location>
            <begin position="63"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="64"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="106"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="148"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="190"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="233"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="275"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW79233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="359" mass="39058" checksum="5D2F9D019AD11987" modified="2014-03-19" version="1">MDPLEGMDESSTDDDAASQTTEDDPQVPEQPPPSVQPQQPAPAPAPAPAPGARERPRYELKHTLIGHTQSISSVKFSPDGTLLASCAADNAVKIWSPFTGQLIRNLNGHTKGLSDVAWSSDSVYLASASDDTTIRIWDVDSGLTTKTLKGHTSFVFCVNYNTESTQLVSGGCDGDVRIWNLAKGKCTKTLNAHLDYVTAVHFNRDASLIVSCALDGLIRIWNTSSGQCLKTLAEGHNAICQHVQFSPNSKYILSTAHDSAIRLWDYHTSRCLKTYMGHQNSKYCIAACFSVTGGKWIVSGSEDNKVYLWDLQSREVVQVLDAHKDIVVAVATHPQQNMIASGSIESDLSIRIWADRGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0A5</accession>
    <name>W4K0A5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_36236</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548748.1">
        <property type="nucleotide sequence ID" value="XM_009550453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0A5"/>
    <dbReference type="FunCoup" id="W4K0A5">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K0A5"/>
    <dbReference type="GeneID" id="20671817"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_36236"/>
    <dbReference type="eggNOG" id="KOG3928">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042567_0_1_1"/>
    <dbReference type="InParanoid" id="W4K0A5"/>
    <dbReference type="OrthoDB" id="274828at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019368">
        <property type="entry name" value="Ribosomal_mS29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10236">
        <property type="entry name" value="DAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW79159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="384" mass="42977" checksum="DD9626C9F4C2092F" modified="2014-03-19" version="1">MPMPVGQLQNPIFRDQRVEELNLATFYPAALTEHNLGQAMVLPMPENAPARVFGVPRNILVEYRMLTKPVTVVRDVSLIVADKLQAASQESSEKHRMVFTGMKGNGKSSLLLQAVEFARSNRWIIMYIPRAVDLVNSTTHYTYDLRTQTYLQPVFAYQTLQRFKTVNLSALQSLTTEKVIEVENRSPVPVGTKLADLADIGLNDQAVAPTVLSALMEALGAQTQYPVLLAIDDFQALFTNTTYRDPHFAMLKSWHLSMPRLLMEYAGGEKTFARGAVLGALSSTNTAFKLNAQLGHALKLQPWKKPSPYLKIPPEILRYTKGIERLRVPDRLQVNEAASIFEVWSKTKALHTHADDGLFMAKYTEASGNARDFVWKGLLATLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0C7</accession>
    <name>W4K0C7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_323024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548903.1">
        <property type="nucleotide sequence ID" value="XM_009550608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0C7"/>
    <dbReference type="STRING" id="747525.W4K0C7"/>
    <dbReference type="GeneID" id="20670934"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_323024"/>
    <dbReference type="eggNOG" id="ENOG502S5C5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056576_1_0_1"/>
    <dbReference type="InParanoid" id="W4K0C7"/>
    <dbReference type="OrthoDB" id="2019666at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="194" mass="21491" checksum="70A90CF53F06BD4C" modified="2014-03-19" version="1" fragment="single">RVRINAQKLKAQCFGAAERTVLVTCHLNDTLIGHVFKTRSRWSARVAGWITQLVVNSQHCRHYIATSLLQTLTFHTLFQRVTVFGLASSHPAACNALAKIARLRMNEIDLAFIGANASRVLASSTVGYIKTAELRGTVFGDAHDPAVVSSAFTNFYVSHVEPLDILETYVARSNWSLEELLEGHEFLIIVPVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4K153</accession>
    <name>W4K153_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitotic-spindle organizing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_324627</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for gamma-tubulin complex recruitment to the microtubule organizing center (MTOC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MOZART1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549339.1">
        <property type="nucleotide sequence ID" value="XM_009551044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K153"/>
    <dbReference type="FunCoup" id="W4K153">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K153"/>
    <dbReference type="GeneID" id="20671066"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_324627"/>
    <dbReference type="eggNOG" id="ENOG502S6UI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160285_0_1_1"/>
    <dbReference type="InParanoid" id="W4K153"/>
    <dbReference type="OrthoDB" id="48571at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000931">
        <property type="term" value="C:gamma-tubulin ring complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031021">
        <property type="term" value="C:interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033566">
        <property type="term" value="P:gamma-tubulin complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051415">
        <property type="term" value="P:microtubule nucleation by interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022214">
        <property type="entry name" value="MZT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520:SF2">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12554">
        <property type="entry name" value="MOZART1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW79070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="79" mass="8574" checksum="22FED1D266C93E73" modified="2014-03-19" version="1">MPLKESERISSAQQTLDTLYEISQLLNTKLDKETLATCVGMIESGVNPEALAAVIQELRRENGALGAQSTANGRHSSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1K3</accession>
    <name>W4K1K3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_410823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549249.1">
        <property type="nucleotide sequence ID" value="XM_009550954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1K3"/>
    <dbReference type="STRING" id="747525.W4K1K3"/>
    <dbReference type="GeneID" id="20672902"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_410823"/>
    <dbReference type="HOGENOM" id="CLU_1326523_0_0_1"/>
    <dbReference type="InParanoid" id="W4K1K3"/>
    <dbReference type="OrthoDB" id="3269405at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="207" mass="23515" checksum="BA609605031AA4B9" modified="2014-03-19" version="1">MPTNAITPLYCLNGPAHWQAEVLPQTQTPTRVVLDYVPPSIGPVIPQRLWRPQSDKLLSSLVHNGALCRPIFFVRRDFDGIGITLEEATHRQHHCLYDYDALVDFGGKTTTSLRILWSGYEEFSRQIQLKDQTRSRNPITLGRWAQYVATTVSRFLEEPPALLNEHDRQPQWAIGDGRITARDIILVGVVHTSAGTWQPILQLVLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2Q4</accession>
    <name>W4K2Q4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_234416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548539.1">
        <property type="nucleotide sequence ID" value="XM_009550244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2Q4"/>
    <dbReference type="GeneID" id="20668741"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_234416"/>
    <dbReference type="HOGENOM" id="CLU_3037929_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2Q4"/>
    <dbReference type="OrthoDB" id="3172239at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="55" mass="5834" checksum="CB271FC950211188" modified="2014-03-19" version="1" fragment="single">TTSPAIPRLPSDVADDFSSPGSQTTSAASAIFHVHSIPPEILTCIFLWLITLNPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4K302</accession>
    <name>W4K302_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_428433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548708.1">
        <property type="nucleotide sequence ID" value="XM_009550413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K302"/>
    <dbReference type="STRING" id="747525.W4K302"/>
    <dbReference type="GeneID" id="20674276"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_428433"/>
    <dbReference type="HOGENOM" id="CLU_407712_0_0_1"/>
    <dbReference type="InParanoid" id="W4K302"/>
    <dbReference type="OrthoDB" id="107110at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33266">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33266:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW80197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="674" mass="75546" checksum="BF178E0C9F4C6969" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4K398</accession>
    <name>W4K398_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_322524</name>
        <name evidence="6" type="ORF">HETIRDRAFT_322574</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548348.1">
        <property type="nucleotide sequence ID" value="XM_009550053.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548374.1">
        <property type="nucleotide sequence ID" value="XM_009550079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K398"/>
    <dbReference type="GeneID" id="20670868"/>
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        <source>
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        </source>
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        </source>
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</entry>
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        <submittedName>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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            <end position="72"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW79880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="550" mass="60361" checksum="0D79D8499D6B1838" modified="2014-03-19" version="1"> </sequence>
</entry>
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    <accession>W4K444</accession>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
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                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Velez H."/>
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                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="1140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW80115.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="1140" mass="128117" checksum="763A4366E47C7C01" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4A5</accession>
    <name>W4K4A5_HETIT</name>
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        <alternativeName>
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        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HETIRDRAFT_476321</name>
    </gene>
    <organism evidence="17 18">
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        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="4"/>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547366.1">
        <property type="nucleotide sequence ID" value="XM_009549071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4A5"/>
    <dbReference type="FunCoup" id="W4K4A5">
        <property type="interactions" value="670"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K4A5"/>
    <dbReference type="GeneID" id="20677674"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_476321"/>
    <dbReference type="eggNOG" id="KOG2007">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013528_3_1_1"/>
    <dbReference type="InParanoid" id="W4K4A5"/>
    <dbReference type="OrthoDB" id="438179at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1910:FF:000005">
        <property type="entry name" value="Cysteine-tRNA ligase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.640">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="15">
        <location>
            <begin position="66"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Cysteinyl-tRNA synthetase class Ia DALR" evidence="16">
        <location>
            <begin position="556"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="755"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF09190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETW80642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="808" mass="91360" checksum="88446379CE8A18FA" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4K1</accession>
    <name>W4K4K1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_101800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547398.1">
        <property type="nucleotide sequence ID" value="XM_009549103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4K1"/>
    <dbReference type="GeneID" id="20665797"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_101800"/>
    <dbReference type="HOGENOM" id="CLU_600009_0_0_1"/>
    <dbReference type="InParanoid" id="W4K4K1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="456" mass="49435" checksum="B9E4B8C8272781B1" modified="2014-03-19" version="1">MTPTLPVPISATARALCLPFFGINVTSANSDPRNGLACTQTSRPALGHPRSTAAHALGPSLLIARLRLPPGVRSQLISLRAQRHVPVVHAPPSLILSRLLVECILPLRQANLQRAVASRLKPFSTPPGCGDAGRGTCHRGSMHLGFRILPASGHLNSVTFCVSKLDGGGPQLPPARLPQTVQQVPNPSETFGLRVPHIRVHPSSHQLGPRLAPSSPALARRKTPVVWAPVDSLHNADICACRDVRSIGVFHPRVLSCGPGWDLRHFHSATGRFCDFRGVTRGSVGAGVAEVFDKLRSARPSILMEASTVAAFGARIACVTYPSVPFIFARAHQRTDQQTPYVVPRRPTSPHDMNHLDGRTPPSGRATMTRPHASHSFIHSRRSTFFPRQPRRREIAPFIRAVGWPVRERQRRLRTPNGRGGSEVRRRATGDAAVAPCVPAGRMAFSAPIPPLEDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2024-01-24" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5A2</accession>
    <name>W4K5A2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_410157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547672.1">
        <property type="nucleotide sequence ID" value="XM_009549377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5A2"/>
    <dbReference type="GeneID" id="20672842"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_410157"/>
    <dbReference type="HOGENOM" id="CLU_2469368_0_0_1"/>
    <dbReference type="InParanoid" id="W4K5A2"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW80987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="88" mass="10030" checksum="EF254F86249406F5" modified="2014-03-19" version="1">MEIGERVSCKAAYLCRWIIYDAEQLSKVGTLRERSSKEEERQERRNTCAEMRVTGITQNCSIWSRTRGIRRGGIYGAKGEGDNEGQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4K685</accession>
    <name>W4K685_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_246383</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
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                <person name="Stenlid J."/>
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        </citation>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
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    </dbReference>
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    </dbReference>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="231" mass="26253" checksum="D9FC3C873F826750" modified="2014-03-19" version="1" fragment="single">VVTTFHALAIISTVFRLIYRTRVRRLGLDDLFAGFSLCFLFVCLVCIWVRTDTPGPLNQPHRARLIAYWLLTFDFTCCLWSVRLSIIFSIMRVMPPMMNIRRVTQWFSVLFVLMWMALIVQKAVHCTLDISWQKQAEPQCHLGRAIGITELSADFVSDVVLVVLPLRLMWNLQLPTRQRRLLIALFSASMIITLISIVHAVFVIGPAGFLEAMSANIQIAASLMVCNLAVV</sequence>
</entry>
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                <person name="Aerts A."/>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="Lin Y.C."/>
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                <person name="Yakovlev I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
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        </source>
    </evidence>
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    </evidence>
    <sequence length="632" mass="67899" checksum="C7BAE8E53D03E697" modified="2014-03-19" version="1"> </sequence>
</entry>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
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                <person name="Bouzid O."/>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="Deflorio G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
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</entry>
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                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
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                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546140.1">
        <property type="nucleotide sequence ID" value="XM_009547845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6N7"/>
    <dbReference type="GeneID" id="20676134"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_451273"/>
    <dbReference type="eggNOG" id="ENOG502SM3A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019989_1_0_1"/>
    <dbReference type="InParanoid" id="W4K6N7"/>
    <dbReference type="OrthoDB" id="2012566at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43611">
        <property type="entry name" value="ALPHA-D-GLUCOSE 1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43611:SF3">
        <property type="entry name" value="FLAVIN MONONUCLEOTIDE HYDROLASE 1, CHLOROPLATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="54389" checksum="E48F13675D918372" modified="2014-03-19" version="1">MTTFLTSHARAFDSIIFDLGDVLFTWSPAAETPIPPKTLQQILRTATWFEYEKGGILEAECYAAVAREMGLHPEQVRIAFEGARDTLAARSSMVELIRELKQGRKIYAMSNISAPDWEVLRGKLSDWDIFDHVFTSASAKERKPNIGFYRHVLEQTGADPTRTIFVDDKVDNILTARSFGITGVVYDHFNNVERTLRNLCGDPVERAQAFMRANAQHHTTFTSDGHPIKENFSQLLILETTGDASLVENIPESDGPINFFRGNGQFTTAEFPCDVDTTSIGFTISTLASAHNKSRIMDEILKLRDSDNILQVYFDASRPRLDPVVCINALTFFSANGRGHELQESFDWVEAVLTHRAYVDGTRYYETAEAFLFFLSRLLAVSPYARHRLQSVFEERCRERIGMEGDALALAMRIICCSNVGIDLPLERARLLELQQVDGGWDEGWFYKYGSHGVRIANRGVTTAFAIKAIETFAGRKLDSGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6S8</accession>
    <name>W4K6S8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_451281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546148.1">
        <property type="nucleotide sequence ID" value="XM_009547853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6S8"/>
    <dbReference type="GeneID" id="20676136"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_451281"/>
    <dbReference type="HOGENOM" id="CLU_184646_0_0_1"/>
    <dbReference type="InParanoid" id="W4K6S8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="95" mass="10234" checksum="C3DF5029AAF37165" modified="2014-03-19" version="1">MSSGQQQHHTDPRTTPHSFHSPRSLHSPTLSSCNPSWMRLYATSTNALASGCVCARGVLPDVLVFDSAVPQPDAPPKMYSSNSRPRADAPLPPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6Y3</accession>
    <name>W4K6Y3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_173181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546149.1">
        <property type="nucleotide sequence ID" value="XM_009547854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6Y3"/>
    <dbReference type="GeneID" id="20668427"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_173181"/>
    <dbReference type="HOGENOM" id="CLU_1695702_0_0_1"/>
    <dbReference type="InParanoid" id="W4K6Y3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="155" mass="17398" checksum="3327D79A27629E27" modified="2014-03-19" version="1">MQSCVHIVMEIAWTAPRGRHNFPIASVCLYTVQGPHLHLLTLAPKILCLYHTLERCDLAPCIPPVSGTDLLQKTVVSTFLIERNSRDSKDGTFQHLSSARFQGFSYVLHLLQFGSRLFHGSLHYSTYMKGSERSSLRNQSPSIRESVYLGHLAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7W8</accession>
    <name>W4K7W8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sensitive to high expression protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_475358</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SHE9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546437.1">
        <property type="nucleotide sequence ID" value="XM_009548142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7W8"/>
    <dbReference type="FunCoup" id="W4K7W8">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="GeneID" id="20677622"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_475358"/>
    <dbReference type="eggNOG" id="ENOG502QQ1E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025632_3_1_1"/>
    <dbReference type="InParanoid" id="W4K7W8"/>
    <dbReference type="OrthoDB" id="5595506at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008839">
        <property type="entry name" value="MDM33_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961:SF3">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05546">
        <property type="entry name" value="She9_MDM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="17"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="135"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW81839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="391" mass="43246" checksum="374681BBE01CDC6A" modified="2014-03-19" version="1">MLRAVISRPSVFRISAASTSGKSWYSTAHPSSTGDPTLSGAARQDVSTSEPSSPQSTVADTDASPRPPPPDPGSPPADHTSPEDRVAHAREQLRYWTERNAIIVRQRTDELVASLGTSFSQLGGRINKVTGYEEIEALKRRVVDQETRIAAARTAARDAKTAYEEAMQQRSNSQREVNDLLQRKSMWNDADVGRFTVLVRQDHLYEQEEARAKAGVGATEDEVEREFSELMRAILARYHEEQVWSDKIRSVSSYGQLAVLGVNVFVFVLAIVLVEPWKRKRLAQTFERKVEELERANGELVRESINALEGRLEARDRMLESLVLAAEVTRSPSHTEQVVVDEPPETVDEKAGLAIERLVSVSKQRDVAAVLASGAFVAGALGWLARGRFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4K852</accession>
    <name>W4K852_HETIT</name>
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        <recommendedName>
            <fullName evidence="2">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_122931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546591.1">
        <property type="nucleotide sequence ID" value="XM_009548296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K852"/>
    <dbReference type="GeneID" id="20666797"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_122931"/>
    <dbReference type="eggNOG" id="ENOG502RZIN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_5_3_1"/>
    <dbReference type="InParanoid" id="W4K852"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="2">
        <location>
            <begin position="65"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW82007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="276" mass="29646" checksum="38D18CC3DA7BB625" modified="2014-03-19" version="1">MSASASTRHSSSPGTAPPADGPNDRDASGWSANAYRSAAAFVFAPAQTAPVLELLDAQRGERIADLGCGSGEVTLEVVRKVGSAAEGLVVGVDVSESMDPGFLEREGFPGGFIGACDKVFTSAALHWCARDPQGPLQSAWRLLKPGGRLVGEMGGAGNVAGIREALHAALKRRGIDPQPRDPWFFPTVEEYTALLTSVGFKPLHVSLNTRPTRVDDIKAWVRLFCGHNFLEGMSVEEEASVVDEVESLCREDGRCWDKESGVWRVGYFRLRFVAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8U4</accession>
    <name>W4K8U4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_409391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546129.1">
        <property type="nucleotide sequence ID" value="XM_009547834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8U4"/>
    <dbReference type="GeneID" id="20672769"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_409391"/>
    <dbReference type="HOGENOM" id="CLU_990645_0_0_1"/>
    <dbReference type="InParanoid" id="W4K8U4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="281" mass="29827" checksum="C99F41098D353650" modified="2014-03-19" version="1">MPVPSVPRRALPPRKKTPKTPSTPAMPEPAPEPTSSLEPTNVLGASVHVSPSAYGGESSVTEAQATASGDRQEEVGNVNASAEDYFDHSVALAHDRPAVVATASTEIHDDPIAEDDVAEAERATSPSSDARPESPDDPEVYLKPKRDIEPEPAHDPELAVEPLTPLADAPSEDPAGEGQRSDEVEDEEDEAARRQRIAQRLAQMGGVNPLSAPREPSPEHEETGDVPRKSSLEAAPGNRDSNVPVHNFEPTSTPSEPRGSTEGVGLVRKTVGDEITEDGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4K938</accession>
    <name>W4K938_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_173543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546453.1">
        <property type="nucleotide sequence ID" value="XM_009548158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K938"/>
    <dbReference type="GeneID" id="20668454"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_173543"/>
    <dbReference type="HOGENOM" id="CLU_2146189_0_0_1"/>
    <dbReference type="InParanoid" id="W4K938"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="112" mass="12215" checksum="B704227C3B2934AF" modified="2014-03-19" version="1">MPGVRTKNQPASSSACWPYPQSQEPLLRAQYQNILTSRLITFIIFSERCHSAPVPSLHGSSHTSSDKIGAYLINSGAHHCVVWASDGCLYQDSATDFSRSTDNTHPLLGPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9T0</accession>
    <name>W4K9T0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_444413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544893.1">
        <property type="nucleotide sequence ID" value="XM_009546598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9T0"/>
    <dbReference type="STRING" id="747525.W4K9T0"/>
    <dbReference type="GeneID" id="20675578"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_444413"/>
    <dbReference type="eggNOG" id="ENOG502S0NM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_10_4_1"/>
    <dbReference type="InParanoid" id="W4K9T0"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052718">
        <property type="entry name" value="NmrA-type_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47129:SF1">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47129">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="34"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="329" mass="35750" checksum="8EBA7F5BD9544F95" modified="2014-03-19" version="1">MPGHQSTGCPAFGQVGTMLDFSASASIASVESTTGGLGSQILKYILSLNLIPPSQIIISLYNTSSARTDLPSGVQIRQGDFSRPESLDVAFAGADTLLLVSYPSIAHKLRVDSHVNAIDAAKRAGIKRIYYTSLAFADGSVSAVMQAHLDTEAYLKQSGLAYTIVREGIYAESYPLYLGFFDSSKGVDDIYVPGDGPIAWVSREDLGEGMARLIASGTNENQTILFSGPPSNKLTLREVATLLSHCLSRPLALHIVDVEEYVQRFHDETSPWATEAFLRAWAKTFDAMARGETGKVDDLLERILGRPLRSVEEVVRNKLDQEAVTQYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAA6</accession>
    <name>W4KAA6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_317187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546594.1">
        <property type="nucleotide sequence ID" value="XM_009548299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAA6"/>
    <dbReference type="STRING" id="747525.W4KAA6"/>
    <dbReference type="GeneID" id="20670398"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_317187"/>
    <dbReference type="HOGENOM" id="CLU_1065815_0_0_1"/>
    <dbReference type="InParanoid" id="W4KAA6"/>
    <dbReference type="OrthoDB" id="2803082at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="261" mass="29830" checksum="3C89A5ECFD5E8260" modified="2014-03-19" version="1">MQILLSCTFKNQCQQFLGIIGAMNNPPNFPEPTYPSQSSQHDAIYLCRGMNYEDGKAVLRIVIGRNSWQSARRPVQAPTEFASLNIANTCRVSEVHLPRPRIQSVTVLYRPRTARVQFLYLRDLMHPIQFVNKMSGTAWITIQDLLDGKTADILVGPELLVRCLVQNKLTLRLNWRGCKPWNDQFWTRTYSQDPKPITLGKLGERIAAAVRKFKQNFKIAEDSADRLAHTYPSAAELHRVVLIGFIRVSRGSWQPDLRVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAE8</accession>
    <name>W4KAE8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1479-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_315342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545107.1">
        <property type="nucleotide sequence ID" value="XM_009546812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAE8"/>
    <dbReference type="GeneID" id="20670215"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_315342"/>
    <dbReference type="eggNOG" id="ENOG502QUAF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011148_0_0_1"/>
    <dbReference type="InParanoid" id="W4KAE8"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="48456" checksum="D1A05223FB2FB48B" modified="2014-03-19" version="1">MPLRFVDLKREIAASYPNFEARATRAWGEIVEHLHESTKDIIDSGSDVVPQVRFEDLGKLTPQEIDNIKKRGCVVIRDVVDDAEALAWKTSLEEFVKANPSAPGFPETNKQFFHLYWTRAQVLARSHPNLLEATTWLNKLYHIKGQDDLKDVDLSTPLIYADRFRIRHPGTQWDAHPPHVDGGAIERWEDETFRTCFSDILNGNWKRHDPYELEGRINARNSIYGRPNQASVFRTFQGWLAMSETAPHEGTLKVFPDVVASNAYMILRPFFRPIASPVSQDALDPKNWEYDISTPDFPGIFKRDGGFTGPRPNPESHPHFRLEDTMTPVPKVYPGDMVFWHCDVVHSVEEEHTGTRDSAVMYIPAVPMTPLNATYVQRQKETFIQGLTPPDFPKAAPEAGYEGIGKVDDIFGPVGKRAMGFEVEIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAR4</accession>
    <name>W4KAR4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_120750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544815.1">
        <property type="nucleotide sequence ID" value="XM_009546520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAR4"/>
    <dbReference type="GeneID" id="20666711"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_120750"/>
    <dbReference type="HOGENOM" id="CLU_359823_0_0_1"/>
    <dbReference type="InParanoid" id="W4KAR4"/>
    <dbReference type="OrthoDB" id="2801074at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="614"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="755"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="401"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="575"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW82455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="778" mass="84567" checksum="6CBBA452EA743DB8" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBM1</accession>
    <name>W4KBM1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small RNA 2'-O-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.386</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_237411</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>small RNA 3'-end nucleotide + S-adenosyl-L-methionine = small RNA 3'-end 2'-O-methylnucleotide + S-adenosyl-L-homocysteine + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:10415"/>
            <dbReference type="Rhea" id="RHEA-COMP:10416"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:74898"/>
            <dbReference type="EC" id="2.1.1.386"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. HEN1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.386" evidence="11"/>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009547117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBM1"/>
    <dbReference type="FunCoup" id="W4KBM1">
        <property type="interactions" value="158"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KBM1"/>
    <dbReference type="GeneID" id="20668779"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_237411"/>
    <dbReference type="eggNOG" id="KOG1045">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032749_1_0_1"/>
    <dbReference type="InParanoid" id="W4KBM1"/>
    <dbReference type="OrthoDB" id="2154311at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090486">
        <property type="term" value="F:small RNA 2'-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026610">
        <property type="entry name" value="Hen1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21404">
        <property type="entry name" value="HEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21404:SF3">
        <property type="entry name" value="SMALL RNA 2'-O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009026"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00021330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW83129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="371" mass="42314" checksum="046BEFA6DB4C5452" modified="2014-03-19" version="1" fragment="single">DAAELDVTFIPSLYLQRHVWILRTLRRERVCSVIDVGCGEGQLLESLCNPAPRLASPPPPLDTEYPVTEGEQYLHLHTIHALDISAEDLKIAIELTKPPPVAPSGPRDWSWQPRWDEMDVKVWFGGLESVNREMEGVDCIVAMEVIEHLPHHVLDCFAPVLLGAYHPRLLLMTTPSYTFNARFYPPNFTGTRGIPDPTHRTTRVFRHPDHKFEWTPQECKEWCEAAAHDWGYDVLVSGVGKASENDPWGRDADCGFASQVVLFRRREGDDWVKKRKQKSETWLQNRVSEAASMTHKLLVAHKFAKHEKARCPVESERVGSTVQEVMLGWKQAEVVVSELWREERVRASCGGWLEVLLDAVVRNGAFEVRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBR4</accession>
    <name>W4KBR4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_474343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545466.1">
        <property type="nucleotide sequence ID" value="XM_009547171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBR4"/>
    <dbReference type="FunCoup" id="W4KBR4">
        <property type="interactions" value="625"/>
    </dbReference>
    <dbReference type="GeneID" id="20677561"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_474343"/>
    <dbReference type="eggNOG" id="KOG1150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070940_1_0_1"/>
    <dbReference type="InParanoid" id="W4KBR4"/>
    <dbReference type="OrthoDB" id="342454at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620:SF1">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="48"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW83184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="238" mass="27258" checksum="14235C0643564E6C" modified="2014-03-19" version="1">MASSSSSSNNAPPSIISDAELEKLLNREASAFQRELEVERILKAFKLNPYDILDLDETAKPEDVKRKYRQLSLFIHPDKTPHARAPEAFDILKKAESELSDTAKREELDATITQARSVLLKALSLPTNTPDDHPKLKGLEPTFKVQLRIKSKELLIDEEVRRRKAVKMNLANEGFEARKKEEEVTAKKRKAEDDAKWEETREQRVGSWRSFTNNSKKKKKQKVNILGRCPPCLRIDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBS6</accession>
    <name>W4KBS6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Uricase</fullName>
            <ecNumber evidence="7 10">1.7.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Urate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_439423</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 10">Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>urate + O2 + H2O = 5-hydroxyisourate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:21368"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="EC" id="1.7.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 10">Belongs to the uricase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.3.3" evidence="7 10"/>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544887.1">
        <property type="nucleotide sequence ID" value="XM_009546592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBS6"/>
    <dbReference type="FunCoup" id="W4KBS6">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KBS6"/>
    <dbReference type="GeneID" id="20675144"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_439423"/>
    <dbReference type="eggNOG" id="KOG1599">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048151_0_0_1"/>
    <dbReference type="InParanoid" id="W4KBS6"/>
    <dbReference type="OrthoDB" id="9992118at2759"/>
    <dbReference type="UniPathway" id="UPA00394">
        <property type="reaction ID" value="UER00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004846">
        <property type="term" value="F:urate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.270.10:FF:000001">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.270.10">
        <property type="entry name" value="Urate Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002042">
        <property type="entry name" value="Uricase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019842">
        <property type="entry name" value="Uricase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03383">
        <property type="entry name" value="urate_oxi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874:SF1">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01014">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000241">
        <property type="entry name" value="Urate_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00093">
        <property type="entry name" value="URICASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00366">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="4 7 10" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW82531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="327" mass="35935" checksum="5C51577B6D0D0F63" modified="2014-03-19" version="1">MSSNSDPGVLTHARYGKDKVRVLRVVREPGSKVHHIVEYNVTVLLEGDIDTSYTQADNSVVVATDSMKNITYYLAKVSPHILHPTRFALHLGTHLVSKYAHIHKAFVTVEQLRWARIDAGANGTPHTHAFWRDGDEKKIVAVEVDASAGKDALVGKVEAGLRDLLVLKSTGSAFESFVRDEYTTLAEVNDRIFSTSVDLVYTFKPFAIKAPKDDRKLEFDVANVGDAAKSGAPWDGENAQTLARNITLDVFANDESASVQATLYKMAQRLLTEDEHVQTVTYSLPNKHYIPVDMKYIGLDNLTPSAAEVFVPVAAPSGLISATISRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCB2</accession>
    <name>W4KCB2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Laccase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">lcc1</name>
        <name evidence="11" type="ORF">HETIRDRAFT_165789</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545752.1">
        <property type="nucleotide sequence ID" value="XM_009547457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCB2"/>
    <dbReference type="STRING" id="747525.W4KCB2"/>
    <dbReference type="GeneID" id="20668009"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_165789"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_2_1_1"/>
    <dbReference type="InParanoid" id="W4KCB2"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13903">
        <property type="entry name" value="CuRO_3_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF511">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845297" evidence="7">
        <location>
            <begin position="21"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="31"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="161"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="404"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW83507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="533" mass="57766" checksum="C526C2A2F72438E6" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCF1</accession>
    <name>W4KCF1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_408869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009546782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCF1"/>
    <dbReference type="GeneID" id="20672734"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_408869"/>
    <dbReference type="HOGENOM" id="CLU_2746928_0_0_1"/>
    <dbReference type="InParanoid" id="W4KCF1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="71" mass="7812" checksum="ABAAF5FC537D9EB5" modified="2014-03-19" version="1" fragment="single">MQMVSALPGPVDEARGNHDVNCDSTVCAAEDCDPRRVPKAVDVYDQESDRQPSCQNRVCLNLRSRCSVTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCM6</accession>
    <name>W4KCM6_HETIT</name>
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        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_315249</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin AB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545379.1">
        <property type="nucleotide sequence ID" value="XM_009547084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCM6"/>
    <dbReference type="FunCoup" id="W4KCM6">
        <property type="interactions" value="712"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KCM6"/>
    <dbReference type="GeneID" id="20670202"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_315249"/>
    <dbReference type="eggNOG" id="KOG0653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020695_12_3_1"/>
    <dbReference type="InParanoid" id="W4KCM6"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000005">
        <property type="entry name" value="G2/mitotic-specific cyclin B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="122"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="216"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="220"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW83095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="346" mass="39694" checksum="24AED2B374CE6A47" modified="2014-03-19" version="1">MANKNLLVGEDEVEGMIGVTDSEDDEEEEEEAAGLMASNGDVVYAWPDVSPGHAARYQMEVDQIRATFEEDIEGQIDETMVSEYSEDIFEYMSELEEDIMPNPDYMSSQGEVNWGMRQTLVDWIQQVHLRYHMLPETLWIAVNIVDRFLTHRVVSLVKLQLVGVTAMLIASKYEEILAPSVDEFSYMTGNGYTREEILKGERIVLQTIEFKVSHYCSPYSWMRKISKADDYDIQTRTLSKFLTEITLLDHRFLRVKPSLIAAIGMYTARQMLGGDWNDAFVFYSGYTEEQLIPGHNLLIDKLTEPNFETLYICKKYGSKKFFKASGYAVEWARSQIPTEGEGMVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDC7</accession>
    <name>W4KDC7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_443943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543526.1">
        <property type="nucleotide sequence ID" value="XM_009545231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDC7"/>
    <dbReference type="GeneID" id="20675552"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_443943"/>
    <dbReference type="eggNOG" id="ENOG502QRX2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010592_0_0_1"/>
    <dbReference type="InParanoid" id="W4KDC7"/>
    <dbReference type="OrthoDB" id="5382203at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="876"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="932"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="583"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="768"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="896"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="976" mass="104894" checksum="A2D0A9AA8E967E44" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEG4</accession>
    <name>W4KEG4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 2</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD2</name>
        <name evidence="16" type="ORF">HETIRDRAFT_474586</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Golgi apparatus membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Endosome membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C2 domains have an essential, but non-catalytic function. They may facilitate interactions with other proteins and are required for lipid transport function.</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545699.1">
        <property type="nucleotide sequence ID" value="XM_009547404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEG4"/>
    <dbReference type="FunCoup" id="W4KEG4">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KEG4"/>
    <dbReference type="GeneID" id="20677574"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_474586"/>
    <dbReference type="eggNOG" id="KOG2419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002661_2_2_1"/>
    <dbReference type="InParanoid" id="W4KEG4"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04039">
        <property type="entry name" value="C2_PSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00663">
        <property type="entry name" value="PS_decarb_PSD_B_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033179">
        <property type="entry name" value="PSD_type2_pro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023389006" description="Phosphatidylserine decarboxylase 2 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023389005" description="Phosphatidylserine decarboxylase 2 alpha chain" evidence="12">
        <location>
            <begin position="889"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="27"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="217"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="388"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="479"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="479"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="494"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="744"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="802"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="889"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="889"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="888"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETW83451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="939" mass="104727" checksum="B1249A6A372D87F4" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEH9</accession>
    <name>W4KEH9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcineurin subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Calcineurin regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Protein phosphatase 2B regulatory subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_151005</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. Plays a central role in virulence and antifungal drug action.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Composed of a catalytic subunit (A) and a regulatory subunit (B).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543942.1">
        <property type="nucleotide sequence ID" value="XM_009545647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEH9"/>
    <dbReference type="FunCoup" id="W4KEH9">
        <property type="interactions" value="201"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KEH9"/>
    <dbReference type="GeneID" id="20667378"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_151005"/>
    <dbReference type="eggNOG" id="KOG0034">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061288_10_1_1"/>
    <dbReference type="InParanoid" id="W4KEH9"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000047">
        <property type="entry name" value="Calcineurin subunit B type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW84252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="175" mass="19867" checksum="D31BA98626648226" modified="2014-03-19" version="1">MGQSPSQFMEDMEKRSNFNANELERLKKRFMKLDADGSGSIDRDEFLQIPQIANNPLASRMIAIFDEDGGGTVDFQEFVGGLSAFSSRGGREEKLRFAFKVYDMDRDNFISNGELFLVLKMMVGNNLKDAQLQEIVDKTIMEADKDGDGKLSFEEFTQMVSNTDIVKQMTLEDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEW4</accession>
    <name>W4KEW4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_116684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544056.1">
        <property type="nucleotide sequence ID" value="XM_009545761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEW4"/>
    <dbReference type="GeneID" id="20666518"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_116684"/>
    <dbReference type="HOGENOM" id="CLU_756616_0_0_1"/>
    <dbReference type="InParanoid" id="W4KEW4"/>
    <dbReference type="OrthoDB" id="3240950at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="366" mass="41348" checksum="B4344F3E61BBE8FB" modified="2014-03-19" version="1">MPHFNVFRSRRIENSGITEDSNSFNDGQMPRPPERRQHPPSGFRSILTRNRRARPQTNAHTDDEEWQLLDRPPNMRATVEDYSSDEEPAPSDVTDSSVHYISESSAVDSQVPLVEREDEPISSRLYEQFSNSATPHASHVTRLELQDRDIEDHHRSNGSLRPYMDPPISHSPTLSSSSASIVYTLDDGTRVQVPTASYQRGRSSHRQATRKDKTYYIIPPGMNVIFRDKDGSEITRGADVIRTLILSVGDFTGTSTPMRYQEAPIILRDESGRIIYQYVTNLTLIRASYTYPPKDRVAGNTHSRDGPSVVHLGRTTITISIVLSRYIALLAFKAHRAWSTWVKIAHQGPQLLTFGIKPVILEVTTV</sequence>
</entry>
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    <accession>W4KF90</accession>
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            <fullName evidence="7">Beta-catenin-like protein 1 N-terminal domain-containing protein</fullName>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR013180">
        <property type="entry name" value="CTNNBL1_N"/>
    </dbReference>
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        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="104"/>
            <end position="215"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
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        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW83975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="633" mass="71203" checksum="7047573076C5F4FF" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFC5</accession>
    <name>W4KFC5_HETIT</name>
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        <recommendedName>
            <fullName evidence="9">DUF803-domain-containing protein</fullName>
        </recommendedName>
    </protein>
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            <taxon>Agaricomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544201.1">
        <property type="nucleotide sequence ID" value="XM_009545906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFC5"/>
    <dbReference type="GeneID" id="20676897"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_458251"/>
    <dbReference type="eggNOG" id="KOG2922">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012349_2_2_1"/>
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    <dbReference type="OrthoDB" id="165382at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF65">
        <property type="entry name" value="MAGNESIUM TRANSPORTER NIPA9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
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        <location>
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            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="555"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="592"/>
            <end position="602"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFJ1</accession>
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        <submittedName>
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    </protein>
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    <reference evidence="1 2" key="1">
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            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544274.1">
        <property type="nucleotide sequence ID" value="XM_009545979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFJ1"/>
    <dbReference type="GeneID" id="20670065"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_313806"/>
    <dbReference type="HOGENOM" id="CLU_167275_1_0_1"/>
    <dbReference type="InParanoid" id="W4KFJ1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW84627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="60" mass="6953" checksum="45F840B835A34966" modified="2014-03-19" version="1" fragment="single">KDGSRCEAMLQPFKGFVPLMSPFKWYILLCKVVERSGRGSEVFDESAIEVSKAEERLYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KG48</accession>
    <name>W4KG48_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_103290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544426.1">
        <property type="nucleotide sequence ID" value="XM_009546131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KG48"/>
    <dbReference type="GeneID" id="20665888"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_103290"/>
    <dbReference type="HOGENOM" id="CLU_040945_1_0_1"/>
    <dbReference type="InParanoid" id="W4KG48"/>
    <dbReference type="OrthoDB" id="3049938at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW84797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="136" mass="15945" checksum="F7E8D0ECF6E1D839" modified="2014-03-19" version="1">MDYLMTTRESGFDLESTIDYFCQAIHPEILKQIYRLPEMLTTMNDWVKYTRRFDNQWRELQSIKSSVHITVPHRNNPFQYDSSNAPASMNNLVVPMAIDAVHTLLSNDERARLHAEGYMKGELDMFNRVVEKWGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4KH33</accession>
    <name>W4KH33_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aspartate/glutamate/uridylate kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_414274</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542046.1">
        <property type="nucleotide sequence ID" value="XM_009543751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KH33"/>
    <dbReference type="FunCoup" id="W4KH33">
        <property type="interactions" value="255"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KH33"/>
    <dbReference type="GeneID" id="20673163"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_414274"/>
    <dbReference type="eggNOG" id="KOG1154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025400_1_1_1"/>
    <dbReference type="InParanoid" id="W4KH33"/>
    <dbReference type="OrthoDB" id="409889at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000018">
        <property type="entry name" value="Glutamate 5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF3">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="9">
        <location>
            <begin position="15"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="265"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW85168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="488" mass="52186" checksum="5EAF62A9DAB3E5C3" modified="2014-03-19" version="1">MAQKTTRSRHGASSTIVIKLGTSSIVHEKTHHPLLSTLSSVVEVVVHLRAQGHKVVLVSSGAIGVGLQRMDMPARPKSLSGKQALAAIGQGRLIALWDNLFGQFGQPTAQVLLTRGDISDRTRYLNAVNTFKELLSMGVVPIVNENDTVSVSEIKFGDNDTLSAVTSSMIHADYLFLLTDVDGLYTANPRKDPSAKFIEVVSSISSIRTEVSTATLGSSLGTGGMETKLIAAEIATAAGVTTIITSSKNPSNIFPIIEFHNSVKPSVSTPRDDIPSPEISSLSPEPAPLPRPPHTMFTPSRSPLRDLKSWTSHTLSPSGSVIIDAGAHHVLARRDSGGRLLAAGVLGVRGEFASGQAVRIMVRRQAEGNVEDVEAARESYAAGMAHDTPNAFVTSLGPQSRSASGLDLLEFTTAHALPEDDAVVVEKQRTVPDESENWELEEVGRGLANYNWAQITKVRGLNSSHMSQLLGYADSEYVVENITIRVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4KH61</accession>
    <name>W4KH61_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_123965</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544054.1">
        <property type="nucleotide sequence ID" value="XM_009545759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KH61"/>
    <dbReference type="FunCoup" id="W4KH61">
        <property type="interactions" value="360"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KH61"/>
    <dbReference type="GeneID" id="20666854"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_123965"/>
    <dbReference type="eggNOG" id="KOG2429">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003818_2_1_1"/>
    <dbReference type="InParanoid" id="W4KH61"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF5">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844291" description="alpha-1,2-Mannosidase" evidence="9">
        <location>
            <begin position="28"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="10">
        <location>
            <begin position="726"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="837"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="844"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW84376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="877" mass="98510" checksum="0FE18993369A830F" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHL9</accession>
    <name>W4KHL9_HETIT</name>
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        <recommendedName>
            <fullName evidence="11">Nucleoporin Nup82</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_314642</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544227.1">
        <property type="nucleotide sequence ID" value="XM_009545932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHL9"/>
    <dbReference type="FunCoup" id="W4KHL9">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KHL9"/>
    <dbReference type="GeneID" id="20670144"/>
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    <dbReference type="eggNOG" id="ENOG502QUNM">
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    <dbReference type="HOGENOM" id="CLU_006117_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHL9"/>
    <dbReference type="OrthoDB" id="341482at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019321">
        <property type="entry name" value="Nucleoporin_Nup88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037700">
        <property type="entry name" value="NUP88/NUP82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257">
        <property type="entry name" value="NUCLEOPORIN NUP84-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10168">
        <property type="entry name" value="Nup88"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW84576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="846" mass="94554" checksum="C0089FB5D3D239CE" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIG5</accession>
    <name>W4KIG5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_145989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ETW85499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="20667110"/>
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    <dbReference type="eggNOG" id="ENOG502SP02">
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    </dbReference>
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    <dbReference type="OrthoDB" id="3263748at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
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        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="302" mass="33412" checksum="DAC37AE75AEF8B3D" modified="2014-03-19" version="1">MSSESRSLVSYARSKLHSAIGTSSKDKCSLHRWVLLKNSIIRSQPTTVPSCSSSTADVNHVYPTNAVDEEAGDEEVCAEEEHDSFMFPDAGQLANHPSNSAVNDSESQWLDSLLETLGDEDDCEYDSDVHVSLVPVDDDDDSAFTPSTSPMSSSEDLTSHPVYYDPPIPMPYPIVYPPYHSHLISAFEYVPLNSPLDSSYPPLNVALPYCDTDDIDDLPVPDAIEDESDDESDALSTPSTSRSMSAFVDPSTPHSRQQQSLPQVYVDTDDSYFSPFELDPLPFPDDRRTSPLVFNNVYHQEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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            <taxon>Bondarzewiaceae</taxon>
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        </lineage>
    </organism>
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544567.1">
        <property type="nucleotide sequence ID" value="XM_009546272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIR6"/>
    <dbReference type="GeneID" id="20673329"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_416537"/>
    <dbReference type="HOGENOM" id="CLU_2606323_0_0_1"/>
    <dbReference type="InParanoid" id="W4KIR6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW84946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="79" mass="8157" checksum="34E91B388699EFF0" modified="2014-03-19" version="1">MALSFAKRAGRTLALMLHRTMAVRVHDVALLRGRGGALGSAGHMVVRVAGGRGQGALVRCVRGGAQRRVGVPGEEGVGR</sequence>
</entry>
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    <accession>W4KIR9</accession>
    <name>W4KIR9_HETIT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <lineage>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542088.1">
        <property type="nucleotide sequence ID" value="XM_009543793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIR9"/>
    <dbReference type="GeneID" id="20669754"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_310144"/>
    <dbReference type="HOGENOM" id="CLU_187838_0_0_1"/>
    <dbReference type="InParanoid" id="W4KIR9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="71" mass="8081" checksum="883B338E9F940C61" modified="2014-03-19" version="1" fragment="single">DEHAPTLGSEGGIREALGRYQTALNKYRRRQLLPNTVSPYLTNDKPPKDIRQHLGQFAHTSRTHHDHIGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIS6</accession>
    <name>W4KIS6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_416545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
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            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544577.1">
        <property type="nucleotide sequence ID" value="XM_009546282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIS6"/>
    <dbReference type="GeneID" id="20673331"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_416545"/>
    <dbReference type="HOGENOM" id="CLU_2996730_0_0_1"/>
    <dbReference type="InParanoid" id="W4KIS6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="57" mass="6580" checksum="ABA8A5FD14989BB8" modified="2014-03-19" version="1">MYSASRYLLWLLTTMQTVIRVLVKYMIFCGLHEGPLIPRRFNICASLVIHLAKGPLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJ17</accession>
    <name>W4KJ17_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_424524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541956.1">
        <property type="nucleotide sequence ID" value="XM_009543661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJ17"/>
    <dbReference type="GeneID" id="20673976"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_424524"/>
    <dbReference type="HOGENOM" id="CLU_721717_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJ17"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="383" mass="40688" checksum="517E2CCDCA0E046F" modified="2014-03-19" version="1">MPVDALFLLYPLQREEFPARQLGRYSDEVVRKTTSSTPPPTLQHQPEIEPLEVSLQPSISTTPSPKKRKASELEIGTSIEANEEQSRPSHKRGRFEVAHGSVPHATHVEHLGSGQSPSAPHNGSRSSSVPGSSSYFTPPSSPSQDEHRLKYHNIAQREDTLARTEPSSNGFAFSPALSGAISGSSLSGLQDLVALGVVGHNHPSSVRQSPSTISGVILNGFHLPPLGLTHCTAEYAPSPPAAISTGALPSIWDVFSPSALPHRCAVPSPGWNAHTDTAWNHPIPRLYLPCSPSAFGQFEDGGLPSPYLPSSPGAFDQFLGGDIPDLLLPPPLINQLEDDLIPRSPYILAPLLANPPPASEVRLAPYGDLVACGILPGPARTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJ59</accession>
    <name>W4KJ59_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Nuclear transport factor 2</fullName>
            <shortName evidence="3">NTF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_432146</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542210.1">
        <property type="nucleotide sequence ID" value="XM_009543915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJ59"/>
    <dbReference type="FunCoup" id="W4KJ59">
        <property type="interactions" value="686"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KJ59"/>
    <dbReference type="GeneID" id="20674587"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_432146"/>
    <dbReference type="eggNOG" id="KOG2104">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131642_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJ59"/>
    <dbReference type="OrthoDB" id="6507044at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000005">
        <property type="entry name" value="Nuclear transport factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="4">
        <location>
            <begin position="7"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU369002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW85345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="125" mass="13850" checksum="59CF740916E36D64" modified="2014-03-19" version="1">MADINSVAKQFTDFYYTTFDSNRASLQTLYRENSMLSFEGAQTLGAPNISEKLSSLPFERVQHKVTTIDAQPSSPTAASLIVSVTGLLLVDDSPNPLQFSQIFHLIPDAGSYYVFNDIFRLNYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJJ5</accession>
    <name>W4KJJ5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_101044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542109.1">
        <property type="nucleotide sequence ID" value="XM_009543814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJJ5"/>
    <dbReference type="GeneID" id="20665729"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_101044"/>
    <dbReference type="HOGENOM" id="CLU_1540260_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJJ5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="174" mass="19388" checksum="F38D8B3CCDED0743" modified="2014-03-19" version="1">MSFEVQMCETMTVMEVDVAVVENEADILARYTLAIPLFNFLLATLPRDDGPSILSTALTALYQIAHADFLFVHLNDMLSVLRLWPDDVSASLIMNLLYRFGSNNCYRNVALFTFVGEFVVIRHDRPRHDVKFIGTIAFKHDSKFTGYIVSSGDTALGSVALVCGIGLYRSLEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJT0</accession>
    <name>W4KJT0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_309062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542886.1">
        <property type="nucleotide sequence ID" value="XM_009544591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJT0"/>
    <dbReference type="GeneID" id="20669639"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_309062"/>
    <dbReference type="eggNOG" id="ENOG502S45I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137479_0_1_1"/>
    <dbReference type="InParanoid" id="W4KJT0"/>
    <dbReference type="OrthoDB" id="5587367at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051614">
        <property type="entry name" value="UPF0045_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00106">
        <property type="entry name" value="MTH1187 family thiamine-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777:SF1">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="MTH1187/YkoF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine-binding protein" evidence="2">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW86112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="116" mass="12282" checksum="44CE9FA780DAFA69" modified="2014-03-19" version="1" fragment="single">ADFCLIPMGTGHDPSVAEYVAECARVLEKTGLKHQVAQPFTGYGTNLEGPWSAVTQAIHDCHAAVHAKGAPRIATDIRIGTRSAPAVPPEGENARKLRRVQEILAKDKDAAAPSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKF0</accession>
    <name>W4KKF0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_449148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543042.1">
        <property type="nucleotide sequence ID" value="XM_009544747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKF0"/>
    <dbReference type="GeneID" id="20675917"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_449148"/>
    <dbReference type="HOGENOM" id="CLU_2346952_0_0_1"/>
    <dbReference type="InParanoid" id="W4KKF0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844330" evidence="1">
        <location>
            <begin position="27"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="97" mass="10050" checksum="B397B9522BF84F95" modified="2014-03-19" version="1">MTRFFVSFSTMLLLGLSLFAVSPVGAAGLAGDSIAARAADAPTCQCKDIFTNDVDRDTTGSCCARVQGTPVNYGCMTDQTGDFIECCGASNEQGGCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKL8</accession>
    <name>W4KKL8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_230432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543130.1">
        <property type="nucleotide sequence ID" value="XM_009544835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKL8"/>
    <dbReference type="GeneID" id="20668709"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_230432"/>
    <dbReference type="eggNOG" id="ENOG502SJP7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044614_3_1_1"/>
    <dbReference type="InParanoid" id="W4KKL8"/>
    <dbReference type="OrthoDB" id="3250682at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="266" mass="29079" checksum="127E7DE65C0C0A40" modified="2014-03-19" version="1" fragment="single">MGIPLDKAELLALFLETLVYGIFFTLCCITCIVLASVHHGGTHSRKIIMPTAFLMLALATAHLIIDFIRAAHAFITLGSPSGAAIEYFGEVSDGLFLAKSLLYLFQTLAGDSIIIWRCYIVTNRRPMLIALPLIAFIGDIVFGCIIVARMIRAPDGATIFSVLRGSFAAYTSMTLAITAYCTGERPSRSLCAICWRIYQPSREWGGVRTLLPVLMAIIESGALYTAGVLTTLILFLIESNAQFAALDLLMPLVGVVYCLIILQIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLZ4</accession>
    <name>W4KLZ4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Chitin synthase</fullName>
            <ecNumber evidence="2 10">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_40811</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chitin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 10"/>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540316.1">
        <property type="nucleotide sequence ID" value="XM_009542021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLZ4"/>
    <dbReference type="STRING" id="747525.W4KLZ4"/>
    <dbReference type="GeneID" id="20672656"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_40811"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004760_3_0_1"/>
    <dbReference type="InParanoid" id="W4KLZ4"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="van Diepen L.T."/>
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                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
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                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
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                <person name="Murat C."/>
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</entry>
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                <person name="Aerts A."/>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
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                <person name="van Diepen L.T."/>
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                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
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    </reference>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPZ4</accession>
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        </submittedName>
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    <organism evidence="1 2">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
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                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
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                <person name="Murat C."/>
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                <person name="Rouze P."/>
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                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541633.1">
        <property type="nucleotide sequence ID" value="XM_009543338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPZ4"/>
    <dbReference type="GeneID" id="20669592"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_308492"/>
    <dbReference type="HOGENOM" id="CLU_118682_0_0_1"/>
    <dbReference type="InParanoid" id="W4KPZ4"/>
    <dbReference type="OrthoDB" id="3044295at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW87769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="226" mass="25851" checksum="CEB5778D86C19B6C" modified="2014-03-19" version="1" fragment="single">GKVRCISLKAEWVITVWVDKDGSRCEAMLQLFKGFVLFMSPLKWYILLCEVVERSGRGSKVFDESAIEVSKAEERLYVSQVLRGWPGGDSINLDQVHGYIVRGNDKSKVFDCVCFKGTFRRLQEQVVVQKYLHDLGCHAPMFFNGLCEHQDVIHVDCKDLRNNEVMEDDVHHSLKGGGQVAKTKEHYKAFKQAEFSHEGCLPFVTFCYFNIVIPSFDIKLGEDPCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KQ55</accession>
    <name>W4KQ55_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_140760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541122.1">
        <property type="nucleotide sequence ID" value="XM_009542827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KQ55"/>
    <dbReference type="GeneID" id="20667000"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_140760"/>
    <dbReference type="HOGENOM" id="CLU_2855880_0_0_1"/>
    <dbReference type="InParanoid" id="W4KQ55"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW87191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="65" mass="7390" checksum="0360E72B756419AE" modified="2014-03-19" version="1" fragment="single">TVWVAADDYGRASARRAGDTRSCRVFLRARHELRCRRHHEYACWARRGPTDPPTRLSVCAGAAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4KQ93</accession>
    <name>W4KQ93_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_431871</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541456.1">
        <property type="nucleotide sequence ID" value="XM_009543161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KQ93"/>
    <dbReference type="STRING" id="747525.W4KQ93"/>
    <dbReference type="GeneID" id="20674572"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_431871"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_778808_0_0_1"/>
    <dbReference type="InParanoid" id="W4KQ93"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="257"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="276"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="326"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW87570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="341" mass="37675" checksum="EE2F0C58371FA1EE" modified="2014-03-19" version="1">MTHNFSEFAFDYINPDNSKPSQGYDVPFFDTAGEVVVPPVESFELQIDHDLAAFDEDQLQVLFDTAQFAGYRSNEPVFGPGSITASSHSAYDTVSTVSESFYSFPTSPAYAPSSFPFPIEMDFRSLTVGSDYGVTDPSANRYTSGASPDMDLTSFGVLPPSPPTSPPVHYMPKARSEYTPATSSGRYHVPAISQNVSPQLPTVPPVPSVLSVHDRSEIDSEDPRRRHQCPQCNRAFARAYNLKTHLDTHNPERQKSFICPHRSCGRAFSRKHDLQRHRAAIHHDTASSASSVSSISPSSRPYPQKNGISIVSSGRERCQSCGKSWSGRERRCSCNNDLRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4KQQ2</accession>
    <name>W4KQQ2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rgp1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_457174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541597.1">
        <property type="nucleotide sequence ID" value="XM_009543302.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Rgp1"/>
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        <property type="entry name" value="Rgp1"/>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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            <end position="427"/>
        </location>
    </feature>
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            <end position="473"/>
        </location>
    </feature>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW87730.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1011" mass="103777" checksum="E777AB476D6FCA7C" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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    </protein>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
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                <person name="Velez H."/>
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                <person name="Yakovlev I."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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    </dbReference>
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            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
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</entry>
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            <taxon>Agaricomycotina</taxon>
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            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
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                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Yakovlev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
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    </dbReference>
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        </location>
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        </location>
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        </location>
    </feature>
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        <location>
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            <end position="113"/>
        </location>
    </feature>
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        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="204" mass="22299" checksum="F21C4A4F22448BA5" modified="2014-03-19" version="1">MRGRGEGTHRIQMWMFVRGRVLCRTCRSSSRAGSRGRRGRGWDGRLWGGEERGRGGGDHPSRRLPPRPADLPCAPSPRLPSRAPFGPPDQPPTPPPGARIRTLTLLVRGTTTGAHGRPPCPRPPREPPNAPTPSPPHRMTPPRHGADGACKPASRAPSYTQHIHFLGPTPRARITTYVLARTHARTLARDLRASHPPARPHASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMS4</accession>
    <name>W4JMS4_HETIT</name>
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        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009555029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JMS4"/>
    <dbReference type="GeneID" id="20673067"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_412767"/>
    <dbReference type="HOGENOM" id="CLU_070119_0_0_1"/>
    <dbReference type="InParanoid" id="W4JMS4"/>
    <dbReference type="OrthoDB" id="2900663at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW74852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="38936" checksum="CC871BF4E3230C37" modified="2014-03-19" version="1">MPAPLYANTPWLPSELMLEIFEIALIEPRNASSLAFVSKRTTALLYKLLYRNVILSNPERVESFVGVLSAGRARPGSIREHVKRVIITFVDHPPYPMVTCSFIRYILHVCTGAHTFVVPGIISHSLLARSDPPQIRVVPASTTHLTLGHFKESDLLVREPLPPLQLARPLFNNLTHLRIADPWILFTPPSTVLAHLGPLPRLTHFYFAKMVGRGETDEEQFVKDVAEVLRARPALEYFIVGACLPLTGHIKKSELEVFEECVRVSTTWALVRELQKTEKRLLIVRGAFRGGWYREWSKGKHITNGAEPFDFWGETVKEGWLQRDREMLPEEVRPIGRWDWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMV9</accession>
    <name>W4JMV9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_164979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553271.1">
        <property type="nucleotide sequence ID" value="XM_009554976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JMV9"/>
    <dbReference type="GeneID" id="20667957"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_164979"/>
    <dbReference type="HOGENOM" id="CLU_2306516_0_0_1"/>
    <dbReference type="InParanoid" id="W4JMV9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW74794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="100" mass="11180" checksum="D4D29E95DA10D468" modified="2014-03-19" version="1">MRPNRPHRTQLQLSAPSQHKKAACLLSATPPIPRAKQVSGLHPRESCEYKVRALLRSLGPPHQTLSTYVLSSRPPSLLVSALWLPGWQFSPDFPSCEFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4JN30</accession>
    <name>W4JN30_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_127054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553407.1">
        <property type="nucleotide sequence ID" value="XM_009555112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JN30"/>
    <dbReference type="STRING" id="747525.W4JN30"/>
    <dbReference type="GeneID" id="20666970"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_127054"/>
    <dbReference type="eggNOG" id="ENOG502QRFX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_42_1_1"/>
    <dbReference type="InParanoid" id="W4JN30"/>
    <dbReference type="OrthoDB" id="10264707at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052742">
        <property type="entry name" value="Mito_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE ACA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="58"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW74948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="252" mass="27753" checksum="16BD7CF5F736E529" modified="2014-03-19" version="1">MSAYGSISFSSRPSSPLSSTAWKLAPAAANRPQSPFTSITVHHLTSASAASFPGLQELTYRIFSDEVRSGTSYPQEAPVGEYTREEFEAYFWAGDVFIAIGVTTDVGTSSEGTPIEGGIAEAQAWRSWEECVVGFYYVKPNYPGRSSHICNGGFVIPPAHRRFGYGKTLGKSYLHYAPQLGFKASVFNLVYTSNIGSMKIWDSLGFTRAGLIPRAGRLRRVDDQGEEWVDAVVYYRSLVADNAWDSALWNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNH6</accession>
    <name>W4JNH6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_120415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552564.1">
        <property type="nucleotide sequence ID" value="XM_009554269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNH6"/>
    <dbReference type="GeneID" id="20666695"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_120415"/>
    <dbReference type="HOGENOM" id="CLU_1129178_0_0_1"/>
    <dbReference type="InParanoid" id="W4JNH6"/>
    <dbReference type="OrthoDB" id="3266140at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844859" evidence="1">
        <location>
            <begin position="21"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="246" mass="26056" checksum="92E1A49BD99D1F40" modified="2014-03-19" version="1">MMRSFVSTLLFAVFVARVHALPTELHTLGRRDNVCALNLRGATAKDCLVDNKGTFFTLTPPSTITATAVTCKPFNQNVYHHIVELQLLDGALQKTGVCTMITAMIKAQSSVSKAALLQPLSDVINGNKNLNFLASTVNNRKKTVVGNSLKGKGKAAGNDDLNVAVGNYLQLTKASSTDIAKSLDVAVAKIIEQAQTIANALPADSGTGRKKVTTKSDLEKAIATANKSKNPVSTAWQAVLDDAPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNL1</accession>
    <name>W4JNL1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="3">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Nuclear thiol peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HETIRDRAFT_120391</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="3"/>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552595.1">
        <property type="nucleotide sequence ID" value="XM_009554300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNL1"/>
    <dbReference type="FunCoup" id="W4JNL1">
        <property type="interactions" value="203"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JNL1"/>
    <dbReference type="GeneID" id="20666694"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_120391"/>
    <dbReference type="eggNOG" id="KOG0855">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_2_2_1"/>
    <dbReference type="InParanoid" id="W4JNL1"/>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03017">
        <property type="entry name" value="PRX_BCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000157">
        <property type="entry name" value="DOT5p Nuclear thiol peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF23">
        <property type="entry name" value="PEROXIREDOXIN DOT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="128"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETW75147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="278" mass="29746" checksum="0115774639D17E98" modified="2014-03-19" version="1">MFPSVIASRQCAIVRSKAGLLEPKPSWSRTPSNGIRPIIIPSVPGGLLQLARPRPSLLDNPTSTLTTTTTISLFSPPNRFFATNMSDAPRRSARLAGNGTAAVSETPAADPAPKIVPAEEDVAELAKIDLGDSLPSLTLQNEKGEDIDVASLAAEKGVVMFLVPKADTAGCTTQACGFRDVYPDFTEHNFDVYCLSADSPSAQTKWQTKAQLPYPLISDPDRLLIAALGAKENGKTKRSHFIFEKGGKLVDKRNPVTPTESPPAALEFVKSYNTKASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4JP32</accession>
    <name>W4JP32_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_412476</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the profilin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552716.1">
        <property type="nucleotide sequence ID" value="XM_009554421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JP32"/>
    <dbReference type="FunCoup" id="W4JP32">
        <property type="interactions" value="147"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JP32"/>
    <dbReference type="GeneID" id="20673033"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_412476"/>
    <dbReference type="eggNOG" id="KOG1755">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120772_1_0_1"/>
    <dbReference type="InParanoid" id="W4JP32"/>
    <dbReference type="OrthoDB" id="421374at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00148">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000001">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027310">
        <property type="entry name" value="Profilin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604:SF0">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00392">
        <property type="entry name" value="PROFILIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01640">
        <property type="entry name" value="PROFILINPLNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00414">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW75283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="126" mass="13149" checksum="92B636956A0E4BD6" modified="2014-03-19" version="1">MSWQAYVDSNLVGSGKIAKAAILGLQGGVWATSAGYTLSVDEQKAAVAAFSHPDQAQANGFRLAGQKFFTLVANDRSVYGKKQADGAILVKTKQAILVAEYIAPIQAGEATPVVEGLADYLIGVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4JP33</accession>
    <name>W4JP33_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_442731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553305.1">
        <property type="nucleotide sequence ID" value="XM_009555010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JP33"/>
    <dbReference type="STRING" id="747525.W4JP33"/>
    <dbReference type="GeneID" id="20675481"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_442731"/>
    <dbReference type="eggNOG" id="ENOG502QQPX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007526_0_2_1"/>
    <dbReference type="InParanoid" id="W4JP33"/>
    <dbReference type="OrthoDB" id="191037at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW74830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="394" mass="44076" checksum="3C1F2C75A3A027D3" modified="2014-03-19" version="1">MVTNKKIGGEFGEVRAVIDVEQLNAYIGRSVPSIKAPLEVKQFKFGQSNPTYFLTDASGTRFVLRKKPAGQLLSKTAHQIEREYTILHAIHEHNVSPSTSASQRVPAPEPIILCEDISIIGTPFYIMEFLDGRIFTDVRMLEVSPSDRRECWLSAVQSLAALSSLDPAALGLSNFGPSTDYFPRQIKSLTSVSVAQSQAVDIETNEPTGMIPQFDEMVRWYRQNLPDEKKTGLRIVHGDYKLDNMIFHPTENRVIGILDWELCTLGSPLADLANLTTSWAIDISSIKGVDANKFTLMRGFKNTTKDVPIALEELEREYCRLTNQPYPIIEMLFVRSWMLFRLAIISQGIAARYARRQASSEQAYIQGQMFPIVGKLARAVLEDGGVTITAQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPD5</accession>
    <name>W4JPD5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="16">P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HETIRDRAFT_157550</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552814.1">
        <property type="nucleotide sequence ID" value="XM_009554519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPD5"/>
    <dbReference type="FunCoup" id="W4JPD5">
        <property type="interactions" value="583"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JPD5"/>
    <dbReference type="GeneID" id="20667736"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_157550"/>
    <dbReference type="eggNOG" id="KOG0209">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001828_4_1_1"/>
    <dbReference type="InParanoid" id="W4JPD5"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07543">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000058">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000071">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047820">
        <property type="entry name" value="P5A-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23143">
        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1024"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1064"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="domain" description="P5A-ATPase transmembrane helical hairpin" evidence="15">
        <location>
            <begin position="54"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="14">
        <location>
            <begin position="291"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1216"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1216"/>
            <end position="1231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETW75393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1248" mass="139185" checksum="DD8647DDC655B329" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPN6</accession>
    <name>W4JPN6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_331329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552939.1">
        <property type="nucleotide sequence ID" value="XM_009554644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPN6"/>
    <dbReference type="GeneID" id="20671651"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_331329"/>
    <dbReference type="HOGENOM" id="CLU_2922883_0_0_1"/>
    <dbReference type="InParanoid" id="W4JPN6"/>
    <dbReference type="OrthoDB" id="6123450at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW75537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="61" mass="6879" checksum="401B1A1441C478F3" modified="2014-03-19" version="1">MSSETENAQNMARGWKEFSKGIQQRQKPTIVVPCSVNGMVFSADPGQSKLRKLIDMKLHPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPT6</accession>
    <name>W4JPT6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_442754</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553353.1">
        <property type="nucleotide sequence ID" value="XM_009555058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPT6"/>
    <dbReference type="STRING" id="747525.W4JPT6"/>
    <dbReference type="GeneID" id="20675484"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_442754"/>
    <dbReference type="eggNOG" id="ENOG502S7E6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074886_0_0_1"/>
    <dbReference type="InParanoid" id="W4JPT6"/>
    <dbReference type="OrthoDB" id="412109at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038753">
        <property type="entry name" value="NFKBIL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263">
        <property type="entry name" value="I-KAPPA-B-LIKE PROTEIN IKBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263:SF1">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW74886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="349" mass="40194" checksum="A2B82EBACC3A659C" modified="2014-03-19" version="1">MPRSLHFKRTPAEQAAHDARKARRSARRAEKQGEPSRKRQRRERDSPKLRRWASDDEDDDGNGSEEYGPQPARPGAGPSRHMFDPDAIRAEVEEARFREKMFGALDDDERLDFVEARLNDYAHVPKRWRAHGFGAGGVDQDQDLLDADPRLMEDEEYVEWVRAGMWRRKHAAEHAEQQRQQAAFAAIQAEAAAREKAAANARRTKRRERERRRERDTRMLYDQRWRELLQPPAINSEEPAVLSFVDIPWPILKGKLSDGEMLHAISVKELTAEAISSFLFLLDIEQDLDPTGLAKIRKERLRETMLRFHPDKFEGRVMSMVREQDKSAVREGVGAVVRAVSALMGEKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQD6</accession>
    <name>W4JQD6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_119090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551958.1">
        <property type="nucleotide sequence ID" value="XM_009553663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQD6"/>
    <dbReference type="GeneID" id="20666629"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_119090"/>
    <dbReference type="HOGENOM" id="CLU_715835_0_0_1"/>
    <dbReference type="InParanoid" id="W4JQD6"/>
    <dbReference type="OrthoDB" id="3183258at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="206"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW75694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="386" mass="43472" checksum="D20F30055E8B2BE9" modified="2014-03-19" version="1">MRIPLAITTLMQDPSPREGERSWNETRGLSGVLEHEAQWRSSEHDRGEEASQLFSLERCARLPNPHPLFWPWMDDVSQINFARTIQGPIIVGAFLNLILYGVFLAQAHQYLSMFKRDRSWLKILIAYLVVGETVNSVFVMFYSYDRLVNHFAFGVDKLWSAVIICLFAFVACVGAIGVLVAATVAAPTPVDSANFRPIIILWLTFSVAADTMITVILCHHLQTHKTGFSETDNMINKIIQFTVQTGLITSLCAIIDLILYLTEKTGHHLIFNLPLAKLYTISLLSSLNSRQGWQLSSHVESNMDHMSGRKEACHLPTTTIGISFATVSELPERTVAHTGRLSMAGRRPAKNHQYKLGCTFAGDKFDSLTDFYYIKVWDDIRGIVHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQF3</accession>
    <name>W4JQF3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_329512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551976.1">
        <property type="nucleotide sequence ID" value="XM_009553681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQF3"/>
    <dbReference type="GeneID" id="20671497"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_329512"/>
    <dbReference type="HOGENOM" id="CLU_679820_0_0_1"/>
    <dbReference type="InParanoid" id="W4JQF3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="405" mass="43024" checksum="7A5782EBA708B813" modified="2014-03-19" version="1">MGYRFPELRFCGGSPANWKAKKVATDNYPAFIQGLLQKEMIHLLRPAPLSAVKRKNPSDNNQLSDSEHNSDIVLIDDLSPSSRGKRQVQKLKTPASARHITAKRARRTHAMPSVAMITQDPLADVFTTTSSPSTAEGQVANTTFTTDDRDGNLFGGNLRQTTVPLSVPDLFAMTLLMPILHTVTQDSSIDSSAPYVTASNHGATTSTVAPTENTSANTNDGATMSTVALTENASTNSVLPLNRASPAGPESGANAPVEPATYNTVSSVVETSNTSITTTGDTNKGHAAAEQSTTTTVMTPNPGVSVEQASGAITMASNLGVPSTCVSSTEARDGGNSAKDTGQPLWPLRTVTARNICGAQWKEQNCDATKEAFDTYWKMLSKQDKKIYTTEAKSMVRIVIKAACL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQM2</accession>
    <name>W4JQM2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mo25-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_437029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mo25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552631.1">
        <property type="nucleotide sequence ID" value="XM_009554336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQM2"/>
    <dbReference type="FunCoup" id="W4JQM2">
        <property type="interactions" value="191"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JQM2"/>
    <dbReference type="GeneID" id="20674928"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_437029"/>
    <dbReference type="eggNOG" id="KOG1566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035755_0_0_1"/>
    <dbReference type="InParanoid" id="W4JQM2"/>
    <dbReference type="OrthoDB" id="609103at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000257">
        <property type="entry name" value="Conidiophore development protein hymA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013878">
        <property type="entry name" value="Mo25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182:SF3">
        <property type="entry name" value="PROTEIN MO25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08569">
        <property type="entry name" value="Mo25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="38459" checksum="9944F293B5975213" modified="2014-03-19" version="1">MNFFKTKQRTPPDLVRGLRDNILKLESSPPGDARKKASEEISKHLQQIKGLLYGDGEPVPELLAQLAQETYSTDLLYFLVLHIGRFDFEARKDAVQIFNNLLRRQIGTRWPTVEYISSKREVLFAALQGYENEEVALNTGMILREMLKHEQLCKILLHSEQFYKYPHYIETTTFGISCDAYSSLKDTLTRHKPMVAEYLDKNYDRFFNSFTTLILSTNYVTKRQSLKLLGEILLDRANFNVMTRYIANEANLKMMMNLLRDKSKNIQFEAFHVFKVFVANPKKPPQIENILRRNKDKLLVYLKNFHNDKDDEQFTDEKQFLIVQIQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRF0</accession>
    <name>W4JRF0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_422709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552336.1">
        <property type="nucleotide sequence ID" value="XM_009554041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRF0"/>
    <dbReference type="STRING" id="747525.W4JRF0"/>
    <dbReference type="GeneID" id="20673843"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_422709"/>
    <dbReference type="HOGENOM" id="CLU_057554_1_0_1"/>
    <dbReference type="InParanoid" id="W4JRF0"/>
    <dbReference type="OrthoDB" id="3250044at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="31390" checksum="06DA0E2EF0D22CE7" modified="2014-03-19" version="1">MAESIVLALENDSIPAWLPSPENLVLECLKHGGGPSNITIHQPDGSGAAVVKWGRGVGMSEARTQDFLAKQVNEDNNSVVRVPVVYLAFRLNNVGYIAMQHVGDRDCTRDDFPKIALAVKHLQRIPSPTSAPGPVNGGPIMHCLFSCSLSSVSYSSVELLEEHINALLASRRWPWRVDFAEKAGIPLSLCIDDLHWGNFRIDSSGLIYSIDHARTNFLPLAFRHLSLAEGEELAMMLEEPVKGAESLQLWAMRLASGAFNMTTSGSSKALPDFLRELEGVYYSLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRY4</accession>
    <name>W4JRY4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_54146</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551872.1">
        <property type="nucleotide sequence ID" value="XM_009553577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRY4"/>
    <dbReference type="FunCoup" id="W4JRY4">
        <property type="interactions" value="831"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JRY4"/>
    <dbReference type="GeneID" id="20678288"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_54146"/>
    <dbReference type="eggNOG" id="KOG0979">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004969_2_0_1"/>
    <dbReference type="InParanoid" id="W4JRY4"/>
    <dbReference type="OrthoDB" id="10254973at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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            <end position="342"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
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        <location>
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            <end position="334"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
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            <end position="471"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
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            <end position="770"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="957"/>
            <end position="1008"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW75646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1199" mass="136418" checksum="735366584D6A4231" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JS96</accession>
    <name>W4JS96_HETIT</name>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">HETIRDRAFT_105898</name>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_105898"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="219"/>
            <end position="291"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="291" mass="32028" checksum="876FC949973814E9" modified="2014-03-19" version="1">MSSRLTRHRGKQTPGAVFTSVRPSLTPHARLRYQPPARARVPSPNITSKPPNRARRHQSIGVVPATGRLARVSRFPYQEKQVPSQGRVGTQEPRQPSLPHLTSTHPLTAERWHLQAAHPTRASQPASPPIHPAALSRTPSPSRFARTRAHRSRPPRSPGAPALARTQRSTTGCAHRAAIDPTRASPTVRATARPTFDSPIGARTRAPSPIHRADRILRGSTKPHEAPRPTTTATKRPGARHAHACPLTHHSLGRTITERARNTRTHPTPRPAFHNRQKTPQITPLFSRAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSI1</accession>
    <name>W4JSI1_HETIT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_247452</name>
    </gene>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_247452"/>
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    <dbReference type="InParanoid" id="W4JSI1"/>
    <dbReference type="OrthoDB" id="3223377at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="103" mass="11949" checksum="C3E431B947F8218B" modified="2014-03-19" version="1" fragment="single">FLGALFNWGLYGVLTSQVYMYSYYYPKDRVQTKAMVYGLYIWEMVQTILFTIDAYNLYASGWGDPDKLLSLGMVWFSSTIMSGIADGVVQLFYAWRIFKLTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTA8</accession>
    <name>W4JTA8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Essential protein Yae1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_328534</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009553345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTA8"/>
    <dbReference type="STRING" id="747525.W4JTA8"/>
    <dbReference type="GeneID" id="20671421"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_328534"/>
    <dbReference type="eggNOG" id="KOG4595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093191_1_1_1"/>
    <dbReference type="InParanoid" id="W4JTA8"/>
    <dbReference type="OrthoDB" id="48036at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052436">
        <property type="entry name" value="LTO1_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532">
        <property type="entry name" value="GEO13458P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532:SF1">
        <property type="entry name" value="ORAL CANCER OVEREXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="3">
        <location>
            <begin position="20"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW76768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="174" mass="19701" checksum="BCCC7DB187CEDCDF" modified="2014-03-19" version="1">MADFDLEDLVDVEQTFYNSGYEDGFAHGRIHGLIEGRALGKEKGFEMWEEIAFYEGFARAWVAFYALTGWTDDRVMHHARQLLDITSHFPRVNPSTSLTGSDDDGVDISALQRQTRSRYKLLCATLGIRPSLRAADVDDDRMDDADGANRDKRKKNVWKVEGPPIPKSEQGLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4JU88</accession>
    <name>W4JU88_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_454503</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550663.1">
        <property type="nucleotide sequence ID" value="XM_009552368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JU88"/>
    <dbReference type="GeneID" id="20676526"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_454503"/>
    <dbReference type="eggNOG" id="ENOG502SRIE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1305014_0_0_1"/>
    <dbReference type="InParanoid" id="W4JU88"/>
    <dbReference type="OrthoDB" id="444848at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW77117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="211" mass="23855" checksum="3B899178263A8D73" modified="2014-03-19" version="1">MLQRKTSSALADWIFEDILCRWGTLVEIVSNNGPAFVKALNQLAKKYHVWHIRISGYNSRANGIAERPYFNVRQALFKAVDGDQAKWNHAAHFVFWADHITVQHRMGCLPYFAVTRTHPLLPLNIAKATYLLPPLTTTLSTTDFIAQWAIALQNTDQTLPTFAAQLLLKLTNLEALLNISQERLWAMEDSQLSNNDTKNDSADEDTNTSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUN9</accession>
    <name>W4JUN9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_327968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551498.1">
        <property type="nucleotide sequence ID" value="XM_009553203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUN9"/>
    <dbReference type="GeneID" id="20671378"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_327968"/>
    <dbReference type="HOGENOM" id="CLU_000384_22_7_1"/>
    <dbReference type="InParanoid" id="W4JUN9"/>
    <dbReference type="OrthoDB" id="8023605at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="119" mass="13399" checksum="28D0B9D362C34939" modified="2014-03-19" version="1" fragment="single">FKQQHLATLCNFNFHQGLLVLMRNTAIEKALNQKMHPQYLGLLLVISRNRGGAYILAKLDGSVFDQPVAAFRVIPYFARRSLKLADLEALLDISQEHLQAMEDSRSRDNDDDAALATSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUW8</accession>
    <name>W4JUW8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="4 15">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HETIRDRAFT_156565</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids. SPC associates with the translocon complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase S26B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 15"/>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550867.1">
        <property type="nucleotide sequence ID" value="XM_009552572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUW8"/>
    <dbReference type="FunCoup" id="W4JUW8">
        <property type="interactions" value="286"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JUW8"/>
    <dbReference type="GeneID" id="20667647"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_156565"/>
    <dbReference type="eggNOG" id="KOG3342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089996_0_1_1"/>
    <dbReference type="InParanoid" id="W4JUW8"/>
    <dbReference type="OrthoDB" id="10257561at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
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        <property type="entry name" value="SPASE_I_1"/>
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    <keyword evidence="10 15" id="KW-0735">Signal-anchor</keyword>
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            <begin position="12"/>
            <end position="35"/>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047037"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362047"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW77348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="188" mass="21167" checksum="228786E3BA494CC9" modified="2014-03-19" version="1">MLGDTLKTVRKLGIRYVLLQMLNFASVIASGLMIWKGLGLLTNTESPIVVVLSGSMEPAFYRGDLLFLTNPPNTRYQNGDITVYKIPGQDIPIVHRVLETHDVSKKVKGVRLEPKPEDQLLLTKGDNNYLDDIELYQGLEWLERRHIVGKVRGFLPYVGYVTIAMNDFPQLKYALLGGLGLLALIQRE</sequence>
</entry>
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    <accession>W4JVQ5</accession>
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        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 69 protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">HETIRDRAFT_52325</name>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
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                <person name="Rouze P."/>
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                <person name="Solheim H."/>
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                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
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    </dbReference>
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    </dbReference>
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            <begin position="51"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW77559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="519" mass="58709" checksum="C8C49A62E7DCED62" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4JW62</accession>
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        <recommendedName>
            <fullName evidence="7">Enhancer of polycomb-like protein</fullName>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
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                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M.</text>
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        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the enhancer of polycomb family.</text>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14898">
        <property type="entry name" value="ENHANCER OF POLYCOMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="15"/>
            <end position="210"/>
        </location>
    </feature>
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            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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            <end position="948"/>
        </location>
    </feature>
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        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="786"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="915"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW77315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="948" mass="105669" checksum="F4BAE096CDC241E1" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWQ4</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">HETIRDRAFT_163861</name>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549901.1">
        <property type="nucleotide sequence ID" value="XM_009551606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWQ4"/>
    <dbReference type="GeneID" id="20667874"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_163861"/>
    <dbReference type="HOGENOM" id="CLU_2638362_0_0_1"/>
    <dbReference type="InParanoid" id="W4JWQ4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW77884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="77" mass="8038" checksum="FEC5F3D356D67E87" modified="2014-03-19" version="1">MRFPCCGAMRCSPTTKSAALRSQQHVYTRVDSPHVSMHIHSSSAAMAATTRSARCAVESSLAAGSVATARALIVCSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWT4</accession>
    <name>W4JWT4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_327283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551037.1">
        <property type="nucleotide sequence ID" value="XM_009552742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWT4"/>
    <dbReference type="GeneID" id="20671313"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_327283"/>
    <dbReference type="HOGENOM" id="CLU_1652368_0_0_1"/>
    <dbReference type="InParanoid" id="W4JWT4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW77550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="160" mass="18713" checksum="A0B6FC5DB3E74C43" modified="2014-03-19" version="1">MRFHDFPGGLDELSSDEKMYVDILLGDEIYINIDKKYDDLVELIRGFNRFLSLNSPFSSSIECSDDCGGLFGRLFNFLNGLTLEEFCELYVTWDIKKQNCALVVIQYKLMHAVFNSSWTIRKCLELLSTRRFNDDDRDADKILLGPFHRELLQETNQITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWT8</accession>
    <name>W4JWT8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase family 32 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_239633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550033.1">
        <property type="nucleotide sequence ID" value="XM_009551738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWT8"/>
    <dbReference type="STRING" id="747525.W4JWT8"/>
    <dbReference type="GeneID" id="20668832"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_239633"/>
    <dbReference type="eggNOG" id="ENOG502QRTH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036116_0_0_1"/>
    <dbReference type="InParanoid" id="W4JWT8"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051981">
        <property type="entry name" value="Glycosyltransf_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042:SF21">
        <property type="entry name" value="ALPHA1,4-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042">
        <property type="entry name" value="LACTOSYLCERAMIDE 4-ALPHA-GALACTOSYLTRANSFERASE ALPHA- 1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW78028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="42652" checksum="4A8CD6595C0BF27A" modified="2014-03-19" version="1" fragment="single">VLLLLKIIAPALFLLVFGGFFLWEPHIELAFYERAWVQREIVPIEPLAGCFNNERVSAMYNVSERVYGPRRNEVQAGVSLRLGLDCYDFAGTLRAPPDHELEGVTNFHSYWRTDLAPFGERQEWMLKSFFATQPAGHSKFILWSNGDLSGNEMLHGYVSRYPGAFELRVADVADLAKGTELEGSALLRSTDKKAWVDGDLIRLLVVWREGGVWVDMDSLLTRDLSPLLEHEFVTQWDCYDKIYQPFNGALMHFHQHSPYLCEAFHIIATSPAPRASSTDWGALLYLKLWRRLVAGGIPPFKILPFCFSDGRSCRLDNRLPDPFAPDPTDGRWTGGLTRDVGGGLDQKLKNVFAVHLHNQWEKEYPKDGWVRRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXR9</accession>
    <name>W4JXR9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_460196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549723.1">
        <property type="nucleotide sequence ID" value="XM_009551428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXR9"/>
    <dbReference type="STRING" id="747525.W4JXR9"/>
    <dbReference type="GeneID" id="20677053"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_460196"/>
    <dbReference type="eggNOG" id="ENOG502SDHH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025744_0_0_1"/>
    <dbReference type="InParanoid" id="W4JXR9"/>
    <dbReference type="OrthoDB" id="6738456at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="2">
        <location>
            <begin position="245"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW77686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="559" mass="60643" checksum="B901641256B0D36F" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4JY67</accession>
    <name>W4JY67_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_386694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548863.1">
        <property type="nucleotide sequence ID" value="XM_009550568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JY67"/>
    <dbReference type="GeneID" id="20672286"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_386694"/>
    <dbReference type="HOGENOM" id="CLU_2542841_0_0_1"/>
    <dbReference type="InParanoid" id="W4JY67"/>
    <dbReference type="OrthoDB" id="10674337at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="83" mass="9412" checksum="1352CA872AA82619" modified="2014-03-19" version="1">MSSSAPSVPGVHKVDSISAAVTFVEECFSRFRSLAYLEVETGKRSWNKSWWHRSPEGLVKAISSEEGLSAREYFEWEGIWEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYR2</accession>
    <name>W4JYR2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_410683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549004.1">
        <property type="nucleotide sequence ID" value="XM_009550709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYR2"/>
    <dbReference type="STRING" id="747525.W4JYR2"/>
    <dbReference type="GeneID" id="20672889"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_410683"/>
    <dbReference type="HOGENOM" id="CLU_1810739_0_0_1"/>
    <dbReference type="InParanoid" id="W4JYR2"/>
    <dbReference type="OrthoDB" id="3357985at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="16150" checksum="9D3278007F0C7097" modified="2014-03-19" version="1" fragment="single">MSEGQQSLDTMLRFCYPIPDPPLTSIGAIKQALKVGQKFQIAQIESAVRERTISNVRTFDPPETLYALGWRYQLRGVVLAAAKETLRSVNSPTYVDDFDELEGMAYHRLVDYRARCGEVASSAIRSWKLWEQPPPPAIQPCCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZ76</accession>
    <name>W4JZ76_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_324769</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549141.1">
        <property type="nucleotide sequence ID" value="XM_009550846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZ76"/>
    <dbReference type="STRING" id="747525.W4JZ76"/>
    <dbReference type="GeneID" id="20671079"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_324769"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_1"/>
    <dbReference type="InParanoid" id="W4JZ76"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="4"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW78842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="307" mass="33151" checksum="F98A6F67E14E4AF2" modified="2014-03-19" version="1">MSPCVWLITGANSGLGLALAEHVLSRGDKVIATARNIAKLPASLDTASPLQLDLNSSPAEIKAVGLKALEIHGHVDVLVNMAGYGLESPVEELDPTELIAQFQTNFFSAIYLIQALLPSFRFRKSGTILNVSSIGSIDAAAGLSAYTASKAALDAMSEALALELAPWGIRVFIVQPGFFYTNWFATAASIGEASRRAPEESGKTGVYTDLYGLSSRILPYNLGIRRVGDTQKAAQRMFDVATGTGLAEGLEMKEGWLRVLLGRDSGERFLSRVQTWKENVEATEKIWSSTEIDPAKLEEMRREAGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZM5</accession>
    <name>W4JZM5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_410841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549280.1">
        <property type="nucleotide sequence ID" value="XM_009550985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZM5"/>
    <dbReference type="GeneID" id="20672904"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_410841"/>
    <dbReference type="HOGENOM" id="CLU_2292057_0_0_1"/>
    <dbReference type="InParanoid" id="W4JZM5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="101" mass="10984" checksum="16E53F27FB3B7D2B" modified="2014-03-19" version="1">MPSQPGLMHSPNSYTSPSQLPASISQGVAMIQQQQQQQQQQQQSLQQQSSDPDWVNAQRPPQTLVSASRPVSASFGRASGEHAFAPPNGHTPPPVQMRQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZU3</accession>
    <name>W4JZU3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein eL8/eL30/eS12/Gadd45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_387325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549336.1">
        <property type="nucleotide sequence ID" value="XM_009551041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZU3"/>
    <dbReference type="FunCoup" id="W4JZU3">
        <property type="interactions" value="422"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JZU3"/>
    <dbReference type="GeneID" id="20672310"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_387325"/>
    <dbReference type="eggNOG" id="KOG2988">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130502_0_1_1"/>
    <dbReference type="InParanoid" id="W4JZU3"/>
    <dbReference type="OrthoDB" id="1928736at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002172">
        <property type="entry name" value="PRK01018.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00709">
        <property type="entry name" value="RIBOSOMAL_L30E_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="4">
        <location>
            <begin position="16"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW79067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="114" mass="12045" checksum="BB4EE2456ED151DF" modified="2014-03-19" version="1">MAPTKKSKASKSTESIAARLALVVKSGKYTLGYKSALKQMRNSKAKLILIAGNCPPLRKSEIEYYAMLSKTTVHHFAGTNVALGTAAGKLFRVGVMTISDPGDSDLLSVAEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4K048</accession>
    <name>W4K048_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">GH61J</name>
        <name evidence="19" type="ORF">HETIRDRAFT_68440</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549695.1">
        <property type="nucleotide sequence ID" value="XM_009551400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K048"/>
    <dbReference type="STRING" id="747525.W4K048"/>
    <dbReference type="GeneID" id="20678862"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_68440"/>
    <dbReference type="eggNOG" id="ENOG502SKJ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031730_2_1_1"/>
    <dbReference type="InParanoid" id="W4K048"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845080" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="17">
        <location>
            <begin position="23"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="18">
        <location>
            <begin position="23"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="252"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ETW78476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="332" mass="34747" checksum="8C94993C0A824B1F" modified="2014-03-19" version="1">MHPLSIAPALLALAAYLPRAAAHGYLASITIDGTTYKGNVPAGNTDPSPIRQVDTNSPVKGADNPFLNCGQNAQLASQVANANPGSKIDFLWSDIGSNWPHNTGPVMTYMAKCDGTCDKYNSTDAQWFKVDELGMKPDGSTWYQQDIMNGQPVSVTLSNDIAPGQYLIRHEIIALHLAVSPGGAEFYPSCTQVNIGGSQTGQPNQTVTFPGGYTDTEPGILVPDVFNPGLVYSFPGPAMSNLAAIADTATGQGQAPSSAADSPAPASTSAKGQPASPTSAAATGYPTSSPSNSSPSKQCNLKKRTAVNATKRDVASRPKHLSRIMRDLIHHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0M1</accession>
    <name>W4K0M1_HETIT</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_453796</name>
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    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009551307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0M1"/>
    <dbReference type="GeneID" id="20676425"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_453796"/>
    <dbReference type="HOGENOM" id="CLU_487489_0_0_1"/>
    <dbReference type="InParanoid" id="W4K0M1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="131"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
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            <end position="100"/>
        </location>
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW79368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="559" mass="60506" checksum="739174B262F067BF" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1H5</accession>
    <name>W4K1H5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_35598</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009549618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1H5"/>
    <dbReference type="FunCoup" id="W4K1H5">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="GeneID" id="20671795"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_35598"/>
    <dbReference type="eggNOG" id="KOG0754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_5_2_1"/>
    <dbReference type="InParanoid" id="W4K1H5"/>
    <dbReference type="OrthoDB" id="434783at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051752">
        <property type="entry name" value="Mito_2-oxodicarb_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356:SF1">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="8"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="103"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="196"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW79662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="296" mass="32298" checksum="29A2DE2083B0D929" modified="2014-03-19" version="1">MSQGKKPLPFAVTFTAGAIAGISEILTFYPLDVVKTRMQLETGKSQHGLVGSFRNIIKEEGFGRLYRGLVPPLLLEAPKRATKFAANDFWGKTFKNLSGQTQMTQNLSIITGCTAGATESFVVVPFELVKIKLQDKSSTFAGPIEVVKQIVRNDGVLGLYAGMEATFWRHFWWNGGYFGSIFQVRAMMPKAESPQGELFNNFISGSVGGFIGTAVNTPFDVVKSRIQGTAKVPGVVPKYNWTYPGIVTIFRDEGAAALYKGFVPKVLRLAPGGGVLLLVVEFTLDVFRKALGPPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4K286</accession>
    <name>W4K286_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_117774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
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                <person name="Hietala A."/>
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                <person name="Karlsson M."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
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                <person name="Raffaello T."/>
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                <person name="Salamov A."/>
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                <person name="Solheim H."/>
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                <person name="Velez H."/>
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                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    </evidence>
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    </evidence>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    </evidence>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="115" mass="13406" checksum="409A2097C8778D1F" modified="2014-03-19" version="1">MPDARSYAHGLHVRKSIFGIFPVYALSRYSLISYRDIVCSCHGQCYALHRSKTVCVACQGSDFLVLVRCAPFVNVPLVKTLWSRIAHMRRVSRIDLFRYRIMPIVLDLHQRIRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W4K363</accession>
    <name>W4K363_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">fumarate reductase (NADH)</fullName>
            <ecNumber evidence="10">1.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">NADH-dependent fumarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_384796</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="10"/>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547036.1">
        <property type="nucleotide sequence ID" value="XM_009548741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K363"/>
    <dbReference type="FunCoup" id="W4K363">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K363"/>
    <dbReference type="GeneID" id="20672213"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_384796"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011398_4_5_1"/>
    <dbReference type="InParanoid" id="W4K363"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000007">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF1">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="13">
        <location>
            <begin position="504"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="482"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="482"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW80262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="581" mass="62582" checksum="80CB3B274AF60437" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4K397</accession>
    <name>W4K397_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450 monooxygenase 23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cyp23</name>
        <name evidence="9" type="ORF">HETIRDRAFT_171919</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548136.1">
        <property type="nucleotide sequence ID" value="XM_009549841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K397"/>
    <dbReference type="STRING" id="747525.W4K397"/>
    <dbReference type="GeneID" id="20668370"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_171919"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_14_10_1"/>
    <dbReference type="InParanoid" id="W4K397"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW79556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="544" mass="60738" checksum="EE54B87DBEF634A8" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3E5</accession>
    <name>W4K3E5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_418348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547088.1">
        <property type="nucleotide sequence ID" value="XM_009548793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3E5"/>
    <dbReference type="GeneID" id="20673470"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_418348"/>
    <dbReference type="HOGENOM" id="CLU_099534_0_0_1"/>
    <dbReference type="InParanoid" id="W4K3E5"/>
    <dbReference type="OrthoDB" id="2548432at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="193" mass="21407" checksum="BA6104755A923CFB" modified="2014-03-19" version="1">MAAAPPPPPPGLNYIAVISPVLHSVLIGHSFLVLFVPLVCGLLFFSTTNTRRQPVFLLNIFNICLAIAVGIMLDYRGVRLTLDPLSNFPYPFNLSISIMGIIQSLLIDVILLIRLVSVYPRDLVGTRRFVLIITLPVLLKVGRFINLVLLSKTLVALSSGPNAEATILQKWAHAPYIKIEWFGQLIDVSFWSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3I7</accession>
    <name>W4K3I7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_321297</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547155.1">
        <property type="nucleotide sequence ID" value="XM_009548860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3I7"/>
    <dbReference type="STRING" id="747525.W4K3I7"/>
    <dbReference type="GeneID" id="20670736"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_321297"/>
    <dbReference type="eggNOG" id="ENOG502S1FZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054233_0_0_1"/>
    <dbReference type="InParanoid" id="W4K3I7"/>
    <dbReference type="OrthoDB" id="195231at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004843979" evidence="3">
        <location>
            <begin position="21"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW80398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="358" mass="39564" checksum="43211705A2D85DC5" modified="2014-03-19" version="1">MFLLSPTLLFLFSLLSLAHGQDTDTCDPAHNGLRTGTLQYSSDCNATTWCNNGKCDPKGCRKDEFPLGWPDSIDLPTRCNSSSFCPDEGSECLLKMPVGSACQFDRDDECLAPDNFKELRDQSARGLNVNGSICLNFVCTFANVTVGQACEVENTGFTAYGTDGTEFIDIVSRDNCRIGLYCDSQQKVCIQQKALAVSCSADKECLSYNCLASGVCGKDPREPHHVGVWVYVVIAIGIFGGMFGTLFALFFFHGRQRDTEREKRLQYWREQNAFRQNILQMRDTARASIFSSGAAGSPRSTMYSRDGGDDLQAPLVQHGAPTKSSGLRNYVSDDGSYEQGNENEELVMSTPYTHDRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3J3</accession>
    <name>W4K3J3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_247226</name>
        <name evidence="4" type="ORF">HETIRDRAFT_247227</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547160.1">
        <property type="nucleotide sequence ID" value="XM_009548865.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550960.1">
        <property type="nucleotide sequence ID" value="XM_009552665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3J3"/>
    <dbReference type="STRING" id="747525.W4K3J3"/>
    <dbReference type="GeneID" id="20669155"/>
    <dbReference type="GeneID" id="20669156"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_247226"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_247227"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2339135_0_0_1"/>
    <dbReference type="OrthoDB" id="3344688at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW77457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW80403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="98" mass="11223" checksum="E0E04D7EC6DC92A4" modified="2014-03-19" version="1" fragment="single">VDDLAIFASLRRHLEKIKEGLKQIFEMTDLGPIHWLLGIEIKRDRQARTLSLSQAAYIDVIIARFNLDEANPLTTPLDPSFILNSTQSPSTPRQYEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W4K460</accession>
    <name>W4K460_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_320868</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547354.1">
        <property type="nucleotide sequence ID" value="XM_009549059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K460"/>
    <dbReference type="FunCoup" id="W4K460">
        <property type="interactions" value="454"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K460"/>
    <dbReference type="GeneID" id="20670699"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_320868"/>
    <dbReference type="eggNOG" id="KOG0809">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038177_0_0_1"/>
    <dbReference type="InParanoid" id="W4K460"/>
    <dbReference type="OrthoDB" id="10251371at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15845">
        <property type="entry name" value="SNARE_syntaxin16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF83">
        <property type="entry name" value="SYNTAXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="238"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="347"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW80628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="412" mass="44896" checksum="56E8A447A7F60707" modified="2014-03-19" version="1">MSSAPSTSSAASAPTTRSRTLLFISYRDSSARSSRFARTAHYDDAHDEREGLIDAGPGHISLDVQLPPKWYVVDLAEQVEDILAGTQAKISALDRLHAKHVLPGFTDRTTEEREIEAATSEITKDFRHCQSLIQRILSDAAHAFPPASLDAQRHQALAAKNVQRGLAAKVQDLSAAFRKKQRVYMEKLQGHAIKNQDLLIASGVTSLKGSEGLSAVDDDVEAASRTGQYTSQQLLEPDLDLRARDRELTEIAKSIGTLAELFKDLSALVIDQGTLLDSVEYNIEQTATHVSEAAKELEVATRYQKNTGKRKCIFLLLLIIFGLVVVLIFKPRSHGAVAAPIASLAPTPAPSDLPSPSSSSSFEQQPPLAPRARPGPHPNSILDANLNPPIAPARHRLPEARHGLRARRRAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4Y2</accession>
    <name>W4K4Y2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_434783</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547575.1">
        <property type="nucleotide sequence ID" value="XM_009549280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4Y2"/>
    <dbReference type="STRING" id="747525.W4K4Y2"/>
    <dbReference type="GeneID" id="20674774"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_434783"/>
    <dbReference type="eggNOG" id="ENOG502RG69">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_8_2_1"/>
    <dbReference type="InParanoid" id="W4K4Y2"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW80878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="315" mass="34782" checksum="5E3AC7F0E8E817EF" modified="2014-03-19" version="1" fragment="single">MSKLIAVTGATGQQGSSVVEFLLKAPTDTFSIRAITRNPSSPAAQALAARGIEVVQADLASLEQATKAFEGAWGVFGVTQFYEHGFDAEQLHGKHIVEAAKAANVKHIVWSTVEGRDGECGAISWKSKALIEDRVIASGIPYTLVYIPMYYENFWTSFFAPSYDEQKGFNWSIAFLPDVPIFAFSVADLGGLVVPAFSQPEQYNGAKIKTVTEFLTLRELASQFSEVVGEKASLALEMTPEQFEASRFVDHPAAELMYLSWDYVRRAGPDSGVRDQNQTFSIYPHAKTYRQWVKDSQLVKDLVVKLKSEVKTTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5M1</accession>
    <name>W4K5M1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF803-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_434918</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547794.1">
        <property type="nucleotide sequence ID" value="XM_009549499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5M1"/>
    <dbReference type="STRING" id="747525.W4K5M1"/>
    <dbReference type="GeneID" id="20674784"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_434918"/>
    <dbReference type="eggNOG" id="KOG2922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012349_6_3_1"/>
    <dbReference type="InParanoid" id="W4K5M1"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF92">
        <property type="entry name" value="SPICHTHYIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="370"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="443"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="614"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="370"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="501"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="625"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="648"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW81123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="689" mass="73270" checksum="B16680D408C94A8C" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5P2</accession>
    <name>W4K5P2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gelsolin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_155044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009549468.1"/>
    </dbReference>
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    <dbReference type="STRING" id="747525.W4K5P2"/>
    <dbReference type="GeneID" id="20667544"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_155044"/>
    <dbReference type="eggNOG" id="KOG0443">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002568_0_1_1"/>
    <dbReference type="InParanoid" id="W4K5P2"/>
    <dbReference type="OrthoDB" id="6375767at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11290">
        <property type="entry name" value="gelsolin_S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000002">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF130">
        <property type="entry name" value="SEVERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Gelsolin-like" evidence="2">
        <location>
            <begin position="66"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="2">
        <location>
            <begin position="189"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="2">
        <location>
            <begin position="300"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW81084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="386" mass="42983" checksum="D8BC02B5DCB7F30F" modified="2014-03-19" version="1">MAHLTKPVTYDIESSNIALLGSEIEKRVRRHAGDSESSWEDVGTRPGLRIWRIENFNVVDWPKDRYGSFYDGDSYIVLHTYKKDPKSEALSYDLHFWLGAETSQDEAGTAAYKTVELDDHLKGSPVQHREVQGFESSRFLSYFPRCIILRGGVSTGFHHVSAPPPLNVKRLYQISATQSTLATGKSTLVVREVRPKAASLVEGDVFVLDKGVEVWQLNTKASIGKEKFKAAEFVQLVISDREGQCRVVVYDEGSSGAGIFLSEFGVEALTSRGMTDRSVKVPVTLYRVTDSTGTVKFERVSPPTHSSFDSGDAFLLDNSADVAHPAIFIWIGKDASLKERRLAMQYAQQHLYNKRGAGELVHMGVSIIRMNEGSESEEFINIINAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6D5</accession>
    <name>W4K6D5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_417458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545970.1">
        <property type="nucleotide sequence ID" value="XM_009547675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6D5"/>
    <dbReference type="GeneID" id="20673406"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_417458"/>
    <dbReference type="HOGENOM" id="CLU_2236936_0_0_1"/>
    <dbReference type="InParanoid" id="W4K6D5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="105" mass="11508" checksum="96A75C9DC007C2A0" modified="2014-03-19" version="1">MRMPSGTKRPVPQRPVPQRPVPRPCACTSLPHPHQLSFFPLYPTPLTPDRSRTPPCASPLAFRHNLHPQPFHPSYLPPARPMTGCNPLASSMSALAISPAPHPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6W7</accession>
    <name>W4K6W7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_451314</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="148" mass="16747" checksum="2B6CA60A3128B1D1" modified="2014-03-19" version="1">MASPLEVVYMPPANPSPQVQRVLRWAETFSSFERNVGAHFADDVEYHVLPRALQRPVVTRRRACEEGFERQRSLFNFVIHDLVESGSMISVHVSSYGTGANGTLYTNEYFFTFYFRPGGQWEDGLPKIAVVHEFVDSLSTERRAAGGT</sequence>
</entry>
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    <accession>W4K787</accession>
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        <recommendedName>
            <fullName evidence="9">NCA2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">HETIRDRAFT_65000</name>
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            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
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                <person name="Park J."/>
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                <person name="Rouze P."/>
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                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
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                <person name="Yakovlev I."/>
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                <person name="Martin F."/>
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            <dbReference type="PubMed" id="22463738"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_65000"/>
    <dbReference type="eggNOG" id="ENOG502QTT6">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="NCA2-like"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW81697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="685" mass="77173" checksum="0A61687412D8600F" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7M0</accession>
    <name>W4K7M0_HETIT</name>
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        <recommendedName>
            <fullName evidence="6">Sas10 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_156379</name>
    </gene>
    <organism evidence="7 8">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
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            <location evidence="1">Nucleus</location>
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    <dbReference type="FunCoup" id="W4K7M0">
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    <dbReference type="STRING" id="747525.W4K7M0"/>
    <dbReference type="GeneID" id="20667638"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_156379"/>
    <dbReference type="eggNOG" id="KOG3118">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019106_0_0_1"/>
    <dbReference type="InParanoid" id="W4K7M0"/>
    <dbReference type="OrthoDB" id="1924577at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018972">
        <property type="entry name" value="Sas10_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF8">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09368">
        <property type="entry name" value="Sas10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sas10 C-terminal" evidence="6">
        <location>
            <begin position="631"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="401"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="493"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="367"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="535"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="577"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="647"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW81812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="703" mass="76989" checksum="97C33C74F20C5B50" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4K942</accession>
    <name>W4K942_HETIT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_418191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ETW82347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546874.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K942"/>
    <dbReference type="GeneID" id="20673454"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_418191"/>
    <dbReference type="eggNOG" id="ENOG502QQ65">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025071_0_0_1"/>
    <dbReference type="InParanoid" id="W4K942"/>
    <dbReference type="OrthoDB" id="2803005at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="562" mass="62011" checksum="8681856748D03412" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4K950</accession>
    <name>W4K950_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 monooxygenase 35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cyp35</name>
        <name evidence="10" type="ORF">HETIRDRAFT_51586</name>
    </gene>
    <organism evidence="10 11">
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        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="protein sequence ID" value="ETW81875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009547554.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="20678187"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_51586"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_3_1"/>
    <dbReference type="InParanoid" id="W4K950"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW81875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="499" mass="55816" checksum="57D4EA5C9B0CBC97" modified="2014-03-19" version="1">MDPIVSTLSGLVLAVTLALFVYRRSSKSNLPFPPGPKPKFLSGNLDVIPRSYPWLGYAALGKEYGPMIYLRLGLQRSVLVINSASVATDLLESRSGIYSDRPKQWMYGVLANHFLNVFNLSIKHPRFRRYRKLMNSGLNPRATQGYAPLMESEVRTLMRGLYTKPNELSAHVRRNAGAVILKVAYGWTVETNDDYFVKLMEQAVHHMAKANAPGKWLVEDLPALRFVPSWFPGAYFKRRAQYLKEELSRIDKVPFEWASGSFIDSFTSQMLQPDDGSTPDAEEQDIIKWCSGALYGGGADTTVSALVSFVAVMALYPEIQARARAEVDAIVGCDRLPTVEDVPHLRYVNALLWLRWVSLGLPHRLTQDDVYQGYFIPEGTVVLTNIWAILNDPALYPEPEKFIPERYLSENPQPDPRKYAFGFSRRVCPGAHFAETSLTFTTSSVLSALIISKKEDASGKEIEPIVEFSSGLASHLKPSFQCDITPRSAEALALIQADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4K987</accession>
    <name>W4K987_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_451386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546276.1">
        <property type="nucleotide sequence ID" value="XM_009547981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K987"/>
    <dbReference type="GeneID" id="20676148"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_451386"/>
    <dbReference type="HOGENOM" id="CLU_512938_0_0_1"/>
    <dbReference type="InParanoid" id="W4K987"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="531" mass="57093" checksum="93B1C89A39D1778D" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9M5</accession>
    <name>W4K9M5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_316017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544843.1">
        <property type="nucleotide sequence ID" value="XM_009546548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9M5"/>
    <dbReference type="STRING" id="747525.W4K9M5"/>
    <dbReference type="GeneID" id="20670284"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_316017"/>
    <dbReference type="HOGENOM" id="CLU_046876_0_0_1"/>
    <dbReference type="InParanoid" id="W4K9M5"/>
    <dbReference type="OrthoDB" id="312874at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="159"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="322" mass="36995" checksum="6B5F09453642D0C1" modified="2014-03-19" version="1">MAKDDVQDNFWTIETDTFLDHILIWKTADNNVRNVLHTLNSSSAQWLSLLKVPKLEKELYSSFADTANAIIAACSATNPIVELALDIFWQASPNKSPKSPNRWLPQIRPDLLAVIGLKDALDEFKRLNTRIQDLEHQLGSGPEEEAEKEDLKLQRKEVLKKCELWWLRVHVPVEMKLKDSEEEMLEGILQLCSYMWMVLAEQLDRRFAIGLLLCKSKLIVWMCDRSGLVRTCTTIDIHAKPKKFIKVIISLSRLNPSRLGWDTTMRIYRMEMATYHFSTDKDVTVDYYGVSPHGTTWAIQGPRSDGNEGEDRYLTVKALSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAT6</accession>
    <name>W4KAT6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_418129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546740.1">
        <property type="nucleotide sequence ID" value="XM_009548445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAT6"/>
    <dbReference type="GeneID" id="20673450"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_418129"/>
    <dbReference type="HOGENOM" id="CLU_2292055_0_0_1"/>
    <dbReference type="InParanoid" id="W4KAT6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="101" mass="11393" checksum="A491AF6FC4DC5531" modified="2014-03-19" version="1">MTRSILVHSDTSSLSVRFRPRWCTIRNSCPPRALLVGNVTQAMSVHIWKPAQLYCQSSATRLDGGREEHWEMSPTLVIIGSLLSSMDSYQCQSGGYKYEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAW7</accession>
    <name>W4KAW7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_458561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545269.1">
        <property type="nucleotide sequence ID" value="XM_009546974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAW7"/>
    <dbReference type="STRING" id="747525.W4KAW7"/>
    <dbReference type="GeneID" id="20676925"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_458561"/>
    <dbReference type="eggNOG" id="ENOG502S1FD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023125_0_3_1"/>
    <dbReference type="InParanoid" id="W4KAW7"/>
    <dbReference type="OrthoDB" id="10267127at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050126">
        <property type="entry name" value="Ap4A_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850:SF4">
        <property type="entry name" value="ZINC-DEPENDENT ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="72"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW82977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="459" mass="52281" checksum="A8092669F6870D5E" modified="2014-03-19" version="1">MTESPLRRTASFTVVFIFLVVILSFGIGNELSEYAGLFPTNSDRKYHPDFAQYIHVRNVSAKELSLDQTGRRAIVIGDIHGMDQAFHALLENVSYDSKVDTLIHTGDICAKGPHDGSLSVLSYMASHNVTGVRGNHDQMVIEWRAWLDWIQGLENGYGGRWLQEAEAQWEKDNEKRDEDEEKWTKKQKKHARGKDRKWWERIPDGWAMFSDHYNIARAMSTADYKYLRSLPLILHLPSEHTFIVHAGLLPHDPTHSITDRRQPLSHLPSLSKTITDSSLLGIDWPANVRMRPTVPIYRQAQEINLIQEIPQNTDPWVLLNMRSLRRDNKVTKSSKTGKPWADIWNEVMPQCKGFRDAATQSQNSKLRCYPSTIIYGHAASRGLDVNRWTIGLDSGCVYGRRLTAMILEAAHKHKLDVVARADDEDDEDDETDAAKKTPKVIDFGDDGEARLASVQCKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBT8</accession>
    <name>W4KBT8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_439694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545487.1">
        <property type="nucleotide sequence ID" value="XM_009547192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBT8"/>
    <dbReference type="FunCoup" id="W4KBT8">
        <property type="interactions" value="625"/>
    </dbReference>
    <dbReference type="GeneID" id="20675176"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_439694"/>
    <dbReference type="eggNOG" id="KOG1150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070940_1_0_1"/>
    <dbReference type="InParanoid" id="W4KBT8"/>
    <dbReference type="OrthoDB" id="342454at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620:SF1">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="48"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW83209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="227" mass="26008" checksum="11C7D516FFD7F479" modified="2014-03-19" version="1">MASSSSSSNNAPPSIISDAELEKLLNREASAFQRELEVERILQAFKLNPYDILDLDETAKPEDVKRKYRQLSLFIHPDKTPHARAPEAFDILKKAESELSDTAKREELDATITQARSVLLKALSLPTNTPDDHPKLKGLEPTFKVQLRIKSKELLIDEEVRRRKAVKMNLANEGFEARKKEEEVTAKKRKAEDDAKWEETREQRVGSWRSFTNNSKKKKKQKVNILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBX9</accession>
    <name>W4KBX9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_426654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545633.1">
        <property type="nucleotide sequence ID" value="XM_009547338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBX9"/>
    <dbReference type="GeneID" id="20674133"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_426654"/>
    <dbReference type="HOGENOM" id="CLU_888674_0_0_1"/>
    <dbReference type="InParanoid" id="W4KBX9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW83372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="313" mass="33986" checksum="C567BD76A4CFE0AC" modified="2014-03-19" version="1">MSSILSVLETKLREYMLALPDGTTEYKDYEAWRVVRFAAQQQAVKAQALEEEAVRVATAKHEAEEAEAACTASALQVAEEGRQRCQEALVEAMFSGLLDAEEGDCQMAALEAESVLPLPLFLCSPSPSIPVMSSSRPKPSFTPLPSQPYPLVTESDLASATAALHHMSIDLVASPALTNVNGKPLVAAVVVEFTHQRMPSFGRVMLLPGLGHGWMSTVWAPEERNGAGKVFKDPPKLVSGNCLVRPFPLPPPETDCYDCSSVTPRVGGSSLGHSWRMCGTMVSAVRVAQEPEVYCDIAMKTVVGRLQWMRVLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCM0</accession>
    <name>W4KCM0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Quinone oxidoreductase 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">qor19</name>
        <name evidence="1" type="ORF">HETIRDRAFT_157950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545735.1">
        <property type="nucleotide sequence ID" value="XM_009547440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCM0"/>
    <dbReference type="GeneID" id="20667762"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_157950"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_5_1"/>
    <dbReference type="InParanoid" id="W4KCM0"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW83489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="260" mass="27226" checksum="77931F0EB0A1BA13" modified="2014-03-19" version="1">MSLPEVQKALLLAAKGQVLVKIHSSALNPADNYIQSLGIFVEEWPFILPNVSFERASTLPLGLATASIGLYAEKICRGSAGLYPPWEESGRGKYKGQPILVIGGASSVGQFSAYIIGKLSGFSLIITTCSTHSAAYCVAAGATHPIDYYTTPYSELSSVVRVIVGPSTFVSDILAPRGSIVMVATPAVAKDGEEAKDGKRAVNFGAALYGKLTALLEEEAIKPNNMDVLPDGLAGIPDGLKRLLGGVSGVKLVAHPQETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCQ9</accession>
    <name>W4KCQ9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_163255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545154.1">
        <property type="nucleotide sequence ID" value="XM_009546859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCQ9"/>
    <dbReference type="GeneID" id="20667835"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_163255"/>
    <dbReference type="HOGENOM" id="CLU_3014414_0_0_1"/>
    <dbReference type="InParanoid" id="W4KCQ9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="56" mass="6032" checksum="B860ABCB5D8DA818" modified="2014-03-19" version="1">MSRRSIPPSSLGLDRMSRFILVLGGQVSISQGSQRPDRAAIVGYSYVLVEGVIVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4KD53</accession>
    <name>W4KD53_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Actin-related protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">arp3</name>
        <name evidence="9" type="ORF">HETIRDRAFT_66889</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544701.1">
        <property type="nucleotide sequence ID" value="XM_009546406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KD53"/>
    <dbReference type="FunCoup" id="W4KD53">
        <property type="interactions" value="237"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KD53"/>
    <dbReference type="GeneID" id="20678792"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_66889"/>
    <dbReference type="eggNOG" id="KOG0678">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027965_3_0_1"/>
    <dbReference type="InParanoid" id="W4KD53"/>
    <dbReference type="OrthoDB" id="421448at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10221">
        <property type="entry name" value="ASKHA_NBD_Arp3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000029">
        <property type="entry name" value="Actin-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000006">
        <property type="entry name" value="Actin-related protein 3 (ARP3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW83011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="431" mass="47992" checksum="3BB79957062A04E5" modified="2014-03-19" version="1">MSLLAPIICDNGTGYSKVGFAGNSDPSFVFPTAIATRGPASQGSRTGPAVPAKPGNLASKRGVEDLDFFIGDEALANAKTPGYGINYPIRHGQIDNWDYMERYWEQTIFKYLRAEPEDHYFLLTEPPLNPPENREQTAEIFFESFNIQGLYIAVQAVLALAASWSSNQVTDRTLTGTVIDSGDGVTHVIPCAEGYVIGSAIKHIPIAGRDISQFVLNLMRERGEMANVPPEDQLKVAGKVKENYSYVCQDIVKEFRKYDAEPYKFFERYEGEYSVTGRKYSVDVGYERFLAPEIFFNPEIYSSDFLTPLPEIVDGVIQASPIDVRRGLYKNIVLSGGSTMFQHFGHRLKRDLKQLVDQRLEASAVSSGSVQKSSGVDVNVISHKRQRYAVWFGGSLLASLPEFYSSCHTKAQYDEIGPSICRRYQIFGSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDD9</accession>
    <name>W4KDD9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_438872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543603.1">
        <property type="nucleotide sequence ID" value="XM_009545308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDD9"/>
    <dbReference type="GeneID" id="20675085"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_438872"/>
    <dbReference type="HOGENOM" id="CLU_2306501_0_0_1"/>
    <dbReference type="InParanoid" id="W4KDD9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="100" mass="11178" checksum="5F1E84A20B004413" modified="2014-03-19" version="1">MLYSTASFASSRRTPDTRTGSSLRSYSGPGERTDVPSQAARVTAFLIIFLLTANKTRVTGYCRQHTVSSRLAPRRVWGDVASQKRNPDTSERTRRDGVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDI5</accession>
    <name>W4KDI5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_170387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543646.1">
        <property type="nucleotide sequence ID" value="XM_009545351.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="20668279"/>
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        </source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
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    <name>W4KDJ4_HETIT</name>
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        </recommendedName>
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                <person name="Bouzid O."/>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
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                <person name="Wiebenga A."/>
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                <person name="Yakovlev I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <property type="entry name" value="GLYCINE-RICH CELL WALL STRUCTURAL PROTEIN 1-LIKE"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <end position="945"/>
        </location>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
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                <person name="Murat C."/>
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                <person name="Raffaello T."/>
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                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KE34</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543358.1">
        <property type="nucleotide sequence ID" value="XM_009545063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KE34"/>
    <dbReference type="GeneID" id="20670047"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_313578"/>
    <dbReference type="HOGENOM" id="CLU_1496401_0_0_1"/>
    <dbReference type="InParanoid" id="W4KE34"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW83580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="180" mass="20961" checksum="B519981DD9892017" modified="2014-03-19" version="1">MATPSLAHLDDEVFTYSHKKMDEAVLKQIAFCFGTVPQCPPHDVLLSTIIEKCPELYQDSLDEAYLGRINKLLVEYTQLGSMLEDCWEKQSFESIRDLEILWPEREVRYTNYDMDDNSVVPRALSEKGKCVFSYFGTVTELGWRRTFRGNAHKALWRYIVHHQSHSDRAQSPYTQYASII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4KER4</accession>
    <name>W4KER4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_170814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544002.1">
        <property type="nucleotide sequence ID" value="XM_009545707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KER4"/>
    <dbReference type="GeneID" id="20668307"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_170814"/>
    <dbReference type="HOGENOM" id="CLU_3087497_0_0_1"/>
    <dbReference type="InParanoid" id="W4KER4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW84318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="52" mass="5561" checksum="D6CF14A0B6CEB387" modified="2014-03-19" version="1">MSPLGASATASGLIPAQTQHHISTYCSLSPAYQRALQFRATGKREARLCLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEX2</accession>
    <name>W4KEX2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED18</name>
        <name evidence="9" type="ORF">HETIRDRAFT_415594</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543593.1">
        <property type="nucleotide sequence ID" value="XM_009545298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEX2"/>
    <dbReference type="STRING" id="747525.W4KEX2"/>
    <dbReference type="GeneID" id="20673261"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_415594"/>
    <dbReference type="eggNOG" id="ENOG502SD6A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117750_0_0_1"/>
    <dbReference type="InParanoid" id="W4KEX2"/>
    <dbReference type="OrthoDB" id="10018982at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019095">
        <property type="entry name" value="Mediator_Med18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13321:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13321">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION, SUBUNIT 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09637">
        <property type="entry name" value="Med18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW83855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="201" mass="22902" checksum="76C51D8B8127485E" modified="2014-03-19" version="1">MSSYSYELSLFGEFFAQDLKAVLNRIAMHSESARPMHSREIVFEPEDIQQQRNAGQEPALLRARKELLEPESGWMLYSYMKAESSRIHPDATARPWATVQVVGDALSFASALGYVRRSQIYKRGYVFRKGTLAIQMFQQEQVDTRTNQPIPAHTDTLWEVEVKTASPVRGTQEAPLSQTVDALLEVQLLMKGLLDLRRRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEY8</accession>
    <name>W4KEY8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_443980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543611.1">
        <property type="nucleotide sequence ID" value="XM_009545316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEY8"/>
    <dbReference type="FunCoup" id="W4KEY8">
        <property type="interactions" value="598"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KEY8"/>
    <dbReference type="GeneID" id="20675554"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_443980"/>
    <dbReference type="eggNOG" id="KOG1993">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003886_2_0_1"/>
    <dbReference type="InParanoid" id="W4KEY8"/>
    <dbReference type="OrthoDB" id="361693at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="34"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW83875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="834" mass="93541" checksum="9FE2D805AF9C783C" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4KF34</accession>
    <name>W4KF34_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="7">1.1.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_408521</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2</text>
            <dbReference type="Rhea" id="RHEA:21252"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16782"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.1.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the L2HGDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.2" evidence="7"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544125.1">
        <property type="nucleotide sequence ID" value="XM_009545830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KF34"/>
    <dbReference type="STRING" id="747525.W4KF34"/>
    <dbReference type="GeneID" id="20672687"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_408521"/>
    <dbReference type="eggNOG" id="KOG2665">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024775_1_0_1"/>
    <dbReference type="InParanoid" id="W4KF34"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104:SF4">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW84453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="458" mass="50904" checksum="C36DFC72ED1C9482" modified="2014-03-19" version="1">MVRNLTAALNSKGWFKYKMPEWSFDHVVVGGGVVGLTIARQLLQRFPGKTTCLLERHPSAGVEISSRNSEVIHSGLYYPPNSLKSRLCLRGRQLLYDYCEKHDIPFQRTGKLVVATEPNQLPYLEYLRSNARSLLPPPHWTSKGEHDSVLPLELLSGDQARELEPELSPNVIAALWSPETGIIDSHAFMQSLQKDITANFESPLSFQSRVVRVDPTYTGPDGVPGWVVQAVPRFSERLSEDSDTYAIFARVLINASGLSGPLILNSLLDARKRIPMYYARGSYASYTGPGISCVSHLIYPCPEASSSADKGAHAFQSLGTHLTLDLQGKVRFGPDLEWISPPKDTSDVDFWMQYLAPDESRIQDMHEAISRYLPGVELDGLKADYAGIRPKLVPPGGGFQDFVLRKDYDRSFLPNFRRRSGSPMISLMGIESPGLTASLAIAEMVVEDMLVAENDHIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFX1</accession>
    <name>W4KFX1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_146988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544271.1">
        <property type="nucleotide sequence ID" value="XM_009545976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFX1"/>
    <dbReference type="GeneID" id="20667174"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_146988"/>
    <dbReference type="HOGENOM" id="CLU_1606597_0_0_1"/>
    <dbReference type="InParanoid" id="W4KFX1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="166" mass="18270" checksum="82C398FCC6255BAA" modified="2014-03-19" version="1" fragment="single">MVFDGVELPTVASIRRAEGPEMRERGRERARGQKRTREEMNYGEQLARVLHSAFQQNHRELEDTRERGSKDSAGKDTSEAESLPRPATRRPGRLHRRLPSESSSDAEPGAHKSSRAARVIDPEPPTETDAGPSTDIGTTFEPLTSTSVPSTPSSVIEIDTEPNSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFZ0</accession>
    <name>W4KFZ0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_147022</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544388.1">
        <property type="nucleotide sequence ID" value="XM_009546093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFZ0"/>
    <dbReference type="GeneID" id="20667177"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_147022"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008523_12_3_1"/>
    <dbReference type="InParanoid" id="W4KFZ0"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006531479" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="26"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW84758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="514" mass="56867" checksum="230295FDC39F21A5" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KG08</accession>
    <name>W4KG08_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_63479</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543300.1">
        <property type="nucleotide sequence ID" value="XM_009545005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KG08"/>
    <dbReference type="STRING" id="747525.W4KG08"/>
    <dbReference type="GeneID" id="20678642"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_63479"/>
    <dbReference type="eggNOG" id="KOG4178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_7_5_1"/>
    <dbReference type="InParanoid" id="W4KG08"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844216" evidence="3">
        <location>
            <begin position="24"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="65"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW84768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="368" mass="41815" checksum="FF13B96B68E9A589" modified="2014-03-19" version="1">MVKKAQFLAGGLLPLLCGTFAVAEVFNPREYPKQVATCKAVNRAEGKDVDIDLYYVDINPTAEKTLLMVHGWPSLWSSWKYQIEEFKHEYRLLIPDLRGFGSSTHPGDVKSSGNMEDMVSDMICLLEKAEVKSTICVGHDWGSQICYEAGRSRPDIFEAVVGVAIPYIPAGGPFMPTTALLEHLPRLSYQVFFDEHTSDAVNELKKDIRRTLRGTLRTVDSPPPEAFLMQTDSFLAGWSDVKEIDPIPFFSPDEEDYWVEQYGIQKFEYTLEFYTTENRYASWKIAHEQGNYTLHQPVLSVLPTKDPVADWVLAAKLLKSADYLPHITLQTLHGAHWLHIENPDGFNRILRAWLGQLDARAEHSHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KG27</accession>
    <name>W4KG27_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_416354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544327.1">
        <property type="nucleotide sequence ID" value="XM_009546032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KG27"/>
    <dbReference type="GeneID" id="20673315"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_416354"/>
    <dbReference type="HOGENOM" id="CLU_2942020_0_0_1"/>
    <dbReference type="InParanoid" id="W4KG27"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="60" mass="6463" checksum="24AFAFE9F46C4FCA" modified="2014-03-19" version="1">MPLIGRAMGDWISSHKYGFPVKVQQVRTIGAECGGSPESVCDDQPRAVNIDPTQCSSVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGA6</accession>
    <name>W4KGA6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_314046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544389.1">
        <property type="nucleotide sequence ID" value="XM_009546094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGA6"/>
    <dbReference type="GeneID" id="20670085"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_314046"/>
    <dbReference type="HOGENOM" id="CLU_2849959_0_0_1"/>
    <dbReference type="InParanoid" id="W4KGA6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW84759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="65" mass="6909" checksum="EAD4BA5BE7BC7C6A" modified="2014-03-19" version="1">MSPIVSPAPPCSLSQSLLATTNVLIANSKRLVHSLLYRDTCWGATCASRNPVRDDFDDIACSGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGJ5</accession>
    <name>W4KGJ5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MutL C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_381588</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543884.1">
        <property type="nucleotide sequence ID" value="XM_009545589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGJ5"/>
    <dbReference type="STRING" id="747525.W4KGJ5"/>
    <dbReference type="GeneID" id="20672078"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_381588"/>
    <dbReference type="eggNOG" id="KOG1977">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005415_1_0_1"/>
    <dbReference type="InParanoid" id="W4KGJ5"/>
    <dbReference type="OrthoDB" id="429932at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF47">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="5">
        <location>
            <begin position="223"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="4">
        <location>
            <begin position="577"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="395"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="809"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="809"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="820"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW84186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="837" mass="93628" checksum="23F8BB9D1F8618E5" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGR5</accession>
    <name>W4KGR5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphotransferase</fullName>
            <ecNumber evidence="8">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_155537</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="8"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544169.1">
        <property type="nucleotide sequence ID" value="XM_009545874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGR5"/>
    <dbReference type="STRING" id="747525.W4KGR5"/>
    <dbReference type="GeneID" id="20667579"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_155537"/>
    <dbReference type="eggNOG" id="KOG1369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014393_5_0_1"/>
    <dbReference type="InParanoid" id="W4KGR5"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000034">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF30">
        <property type="entry name" value="GLUCOKINASE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="9">
        <location>
            <begin position="19"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="10">
        <location>
            <begin position="223"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="10">
        <location>
            <begin position="401"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW84505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="540" mass="58151" checksum="4AD9C1A0EE693615" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4KH00</accession>
    <name>W4KH00_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_309330</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542019.1">
        <property type="nucleotide sequence ID" value="XM_009543724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KH00"/>
    <dbReference type="FunCoup" id="W4KH00">
        <property type="interactions" value="214"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KH00"/>
    <dbReference type="GeneID" id="20669665"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_309330"/>
    <dbReference type="eggNOG" id="KOG3894">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038403_0_0_1"/>
    <dbReference type="InParanoid" id="W4KH00"/>
    <dbReference type="OrthoDB" id="342981at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019529">
        <property type="entry name" value="Syntaxin-18_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959:SF0">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10496">
        <property type="entry name" value="Syntaxin-18_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="317"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW85138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="407" mass="45947" checksum="AC06E3AFE3F37012" modified="2014-03-19" version="1">MTGADHTTMFHGLVEAKRKEIPEAKRRRLTRPSRRVPGESQREGAPPLMQEYMQEAHNILTHVNTLSRMLANIRKPYLDVHSRHPGTSSRTGERALDFSDLESSFLDRRHFTNEERDQIDLQVRVILTRCAERVKNMEALEKQRTELAAKEANPLLRMLPARLRHDTSTIASEYVAAHNAAVTWYLTRRLAQVSQQQKELQEERVRRHTERTRTLGSGAAQQAMHMSVGDSMMADSYGPPGKSIGASWILGGASSTLANSFASTIGAPYSAASSATALPPDEYGDRYDDDDDDDDDYDVELSASQIQQFESENAQILRAVEDTYASVQQAEVRLLEISALQMELVAQLTRQAEVTDRIYEDAVATSELVEKGNVQLREARRRARDGRMWILLFLIGASLSLLFLHYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHW5</accession>
    <name>W4KHW5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_407493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542314.1">
        <property type="nucleotide sequence ID" value="XM_009544019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHW5"/>
    <dbReference type="STRING" id="747525.W4KHW5"/>
    <dbReference type="GeneID" id="20672604"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_407493"/>
    <dbReference type="eggNOG" id="KOG1256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_988853_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHW5"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF11">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
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    </dbReference>
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        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="275" mass="29586" checksum="9A12095D16AEAB1F" modified="2014-03-19" version="1">MSALDTLVSAHSLSTAFGRTVAYTALYEGTSFATLSSTTLYKTDDTVTLTGIPDILSTKQYPLPSPTILFLTPRHLTDLTTAVVREAEKSVVFRLAWRHKLAGIIDGYMNKDSLWDRLVFEGARTKVLGEGAATLRGLVVSGGIDSTVVTPTRIALSVPFVNAFTHPVVAAPIFASHPLDLQTFAPSANAHVGPPVINVETKLTGVEDDVVEKGGDPVGHLHVRGPIVGRILTVSDNAEPEQKDQEEPWVPTGYKSRAQTNGSFKVWPLVESLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJB4</accession>
    <name>W4KJB4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AT hook domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_60551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJB4"/>
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    <dbReference type="GeneID" id="20678518"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_60551"/>
    <dbReference type="eggNOG" id="ENOG502SCHZ">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133973_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJB4"/>
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    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="14870" checksum="684BAB1703E51E65" modified="2014-03-19" version="1">MSASPPPEDIADDNKVGDELDDAAQTGPDDDSGANKADSATTPPVKRSRGRPKGSKNKKSATAAAPPTSIAAGPSTGEKRKRGRPPKPKKPEEEGASGEPPVKRKRGRPPKNPKPIEPVSEDAGEATAPDASAKKKRGRPPKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJF5</accession>
    <name>W4KJF5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_60513</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541847.1">
        <property type="nucleotide sequence ID" value="XM_009543552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJF5"/>
    <dbReference type="STRING" id="747525.W4KJF5"/>
    <dbReference type="GeneID" id="20678516"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_60513"/>
    <dbReference type="eggNOG" id="ENOG502SM5N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026652_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJF5"/>
    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW85819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="730" mass="82394" checksum="9A22D29ACA94C044" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>W4KK07</accession>
    <name>W4KK07_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 17">Glutathione reductase</fullName>
            <ecNumber evidence="3 17">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HETIRDRAFT_379293</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 17">Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="14">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="3 17"/>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542235.1">
        <property type="nucleotide sequence ID" value="XM_009543940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KK07"/>
    <dbReference type="FunCoup" id="W4KK07">
        <property type="interactions" value="468"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KK07"/>
    <dbReference type="GeneID" id="20671962"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_379293"/>
    <dbReference type="eggNOG" id="KOG0405">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_2_2_1"/>
    <dbReference type="InParanoid" id="W4KK07"/>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000003">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000141">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006322">
        <property type="entry name" value="Glutathione_Rdtase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01421">
        <property type="entry name" value="gluta_reduc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004776">
        <property type="entry name" value="PRK06116.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 17" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 14 16" id="KW-0274">FAD</keyword>
    <keyword evidence="6 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0520">NAD</keyword>
    <keyword evidence="8 17" id="KW-0521">NADP</keyword>
    <keyword evidence="14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11 16" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="19">
        <location>
            <begin position="13"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="18">
        <location>
            <begin position="361"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="463"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="194"/>
            <end position="201"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="15">
        <location>
            <begin position="51"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU365016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ETW85371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="474" mass="51368" checksum="B6ADD24842A6FCC6" modified="2014-03-19" version="1">MAPIDKPIDGEKFDIVYIGGGSGGSAGSRRAALYGAKVALIEESGKLGGTCVNVGCVPKKIMWHAADIAEKLHHAAHGYHFDLPKDSSTKFTWSTFKPQRDAYIRWLNDIYDKNVNKEGVAYHEGHAKLTSPTTVQITRPDGKNYSINADNIVIATGGRPTVPSDKQIPGASLGVDSDGFFDLEDQPKRVAVVGAGYIAVELAGVLKALGSETHLIIRKDQVLRTFDPSLSEVLTPWMEHTGLHVHKNSHVLKVEGAKGQTLTVHTDKGEAIEVDTLIWAIGRTANTENLGLEDVGVKTDKKGDIIVDEWQATNLKGVWSIGDVQGKALLTPVAIAAGRRLSNRLYGPEKFKNDKLSYENIPTVVFSHPTIGTVGLTEPEARAKYGDDAVKIYKSNFRALYFSMLAPEHKEPTMYKLVCVGPDERVVGVHIIGAGSDEVLQGFAVAVKMGATKQDFDDTVAIHPTSAEELVTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KK51</accession>
    <name>W4KK51_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_432180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542284.1">
        <property type="nucleotide sequence ID" value="XM_009543989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KK51"/>
    <dbReference type="STRING" id="747525.W4KK51"/>
    <dbReference type="GeneID" id="20674592"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_432180"/>
    <dbReference type="eggNOG" id="KOG1091">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017119_1_0_1"/>
    <dbReference type="InParanoid" id="W4KK51"/>
    <dbReference type="OrthoDB" id="27140at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000038">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000031">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF337">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="137"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="652"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="802"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="652"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="705"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="721"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="821"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW85421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="831" mass="92426" checksum="11FA46FD10CD9B92" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKA5</accession>
    <name>W4KKA5_HETIT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_100859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKA5"/>
    <dbReference type="GeneID" id="20665714"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_100859"/>
    <dbReference type="HOGENOM" id="CLU_3014408_0_0_1"/>
    <dbReference type="InParanoid" id="W4KKA5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="56" mass="6235" checksum="2F7DE1D09AACF6DD" modified="2014-03-19" version="1">MDPLLERFMRPLYLYLLKVSASAVSLEEGYPFLVLTEVSGCEPLAKSFCKPILAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKG4</accession>
    <name>W4KKG4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidylethanolamine binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_145960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542408.1">
        <property type="nucleotide sequence ID" value="XM_009544113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKG4"/>
    <dbReference type="STRING" id="747525.W4KKG4"/>
    <dbReference type="GeneID" id="20667109"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_145960"/>
    <dbReference type="eggNOG" id="KOG3346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043994_2_1_1"/>
    <dbReference type="InParanoid" id="W4KKG4"/>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF140">
        <property type="entry name" value="PEBP-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845456" evidence="1">
        <location>
            <begin position="18"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="275" mass="27686" checksum="6402B2A2B56139A4" modified="2014-03-19" version="1">MFVSAAFVLSLASLVTAQPTNPTLEIEAIQAHFSNAGLVPSLLPTFAPTAFFNLSYSGVGTISPGQKLTKDQVSPTPQLTVMPANDTVKLEGNYTLVMADADVVGTDESKGQTRHWLVNDVTLTGSSPFNVSTASGLAVTEYAGPAPASGSGAHRYVILLLPQGSDFTPPANLSTANVGVSVFNLEDYISTSKLGAAVAGTYITVEEGTATATPSPTSAVVTSTLPAAHASTAGASGTASSTAKTTASTGNAAMSAQGLSTPLALLAAAFGIIMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKJ8</accession>
    <name>W4KKJ8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_43954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541796.1">
        <property type="nucleotide sequence ID" value="XM_009543501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKJ8"/>
    <dbReference type="GeneID" id="20675161"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_43954"/>
    <dbReference type="HOGENOM" id="CLU_3001998_0_0_1"/>
    <dbReference type="InParanoid" id="W4KKJ8"/>
    <dbReference type="OrthoDB" id="5598737at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845461" evidence="1">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="57" mass="6526" checksum="2FAB5CBDC55EC631" modified="2014-03-19" version="1" fragment="single">LVLWCMHSICLGFYLIPTIEGQNDVFSAIYTHFPQAPKIIVYDLACQSTPYYLVQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLF1</accession>
    <name>W4KLF1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_307758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540541.1">
        <property type="nucleotide sequence ID" value="XM_009542246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLF1"/>
    <dbReference type="GeneID" id="20669523"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_307758"/>
    <dbReference type="HOGENOM" id="CLU_118682_0_0_1"/>
    <dbReference type="InParanoid" id="W4KLF1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="159" mass="18198" checksum="D0F1D263FE90F249" modified="2014-03-19" version="1" fragment="single">EDGSRCEAMLQLFKGFVPLMSPLKWYILLCEVVERSGRGSEVFDESAIEVSKAEKRLYFFQVLRGWPGGNSIDLDQVHGYIIHGDDKPEVFDCVRLKGAFRRLQEQVVVQKYLHDLGHHAPMFFNGLCKHQDVIHVDCKDLRNNEVMEDDVHHSLKGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLQ6</accession>
    <name>W4KLQ6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_310568</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543035.1">
        <property type="nucleotide sequence ID" value="XM_009544740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLQ6"/>
    <dbReference type="STRING" id="747525.W4KLQ6"/>
    <dbReference type="GeneID" id="20669787"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_310568"/>
    <dbReference type="eggNOG" id="KOG2231">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050881_0_0_1"/>
    <dbReference type="InParanoid" id="W4KLQ6"/>
    <dbReference type="OrthoDB" id="3838338at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056437">
        <property type="entry name" value="Znf-C2H2_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25447">
        <property type="entry name" value="RING_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23230">
        <property type="entry name" value="zf-C2H2_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="72"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="373"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW86280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="439" mass="48748" checksum="81CEBDDFE957C3A6" modified="2014-03-19" version="1">MPDTATQNSASQKAQRGRRTNKRGRNGGPGSAPTPGAQAKTEGAPRANGAQAVEAASGEDPKDAEIDDSLICWICAEPVKYYSVSECNHRTCHVCVLRLRALYKKLDCTFCKESQPSVIFTVSADRPFSSYSPTDIPHKDFKLSIFFETPEMMEETLVLLRFNCPESTCEHVAQGWNDLKLHVRAVHGKLMCDLCLRNKKVFAHEHALYTPNQLAIHLPSIPHPHRKGAPPEQVEGGVHPLCEFCRECFSGDDELYKHMRERHEECFICKRNEVRDQYFKNYDALEKHFDHAHHPCPNSSCQQRKFVVFGSLLDLQAHMVEEHGADMSSRDKKAASRINVEFQEVNGGRRRGAREREPPPGSQPPGPARSGNSRRDRFAGHLTVEGDTHGSSPGPSRPASPPPADMDPATAECDIFLHAAAVVPLTGVPSGNMRRCSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KM20</accession>
    <name>W4KM20_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_308381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540440.1">
        <property type="nucleotide sequence ID" value="XM_009542145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KM20"/>
    <dbReference type="GeneID" id="20669578"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_308381"/>
    <dbReference type="HOGENOM" id="CLU_871887_0_0_1"/>
    <dbReference type="InParanoid" id="W4KM20"/>
    <dbReference type="OrthoDB" id="3067084at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="331" mass="37795" checksum="086448D5B1E35B7D" modified="2014-03-19" version="1">MEITWRISFSGRTPGKLILGDALGEVTIKPDFNQTKYETQNSHSWSELISHRFYADAHPRRRAVIAYAPSALSFTTHILDIHYWYTRTSTRFISIAGTMHISTSKLALCLISIYSALNAHERTWIGWVSMIPTFLLILVMISPYINMIKVVLRLKWQWKRSNWRTQAPMRRVPATHQERASERLDRRTNHIVMTGLLLALLAYFWVYPDGQVIIPPNIPSSSQDTSLSQWSKTSKALRKAMISVGTIYQILLNHRGHTFAGRHRSATIINFIYEIIGLSVFVPKVVGRFDLRPGLFMTGILSVALSFTLAWQAIWMRGVPHQGGGVDDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4KM86</accession>
    <name>W4KM86_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CSN8/PSMD8/EIF3K domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_309227</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542942.1">
        <property type="nucleotide sequence ID" value="XM_009544647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KM86"/>
    <dbReference type="STRING" id="747525.W4KM86"/>
    <dbReference type="GeneID" id="20669656"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_309227"/>
    <dbReference type="eggNOG" id="ENOG502RSEX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094291_1_0_1"/>
    <dbReference type="InParanoid" id="W4KM86"/>
    <dbReference type="OrthoDB" id="5351233at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010387">
        <property type="term" value="P:COP9 signalosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033205">
        <property type="entry name" value="COP9_CSN8"/>
    </dbReference>
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        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13339">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13339:SF0">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="CSN8/PSMD8/EIF3K" evidence="6">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW86176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="172" mass="18804" checksum="A5B064221BC17A8D" modified="2014-03-19" version="1" fragment="single">PLVLSYLILDDLPPAKFVLTRLPDSIASKPLPQSLFNIFASVWERKYENVYPRAEALMDIAHQADFPEGLASLIATLVTQFVESFRRRTFALISRAYSSIPLALAQAYIGLSQEELLAVTEANQWTYDASSQILTPAPVAGPRSTTYISGTSSPSTLKALDLITDSVALLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMW2</accession>
    <name>W4KMW2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily tetracycline resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_41260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540330.1">
        <property type="nucleotide sequence ID" value="XM_009542035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMW2"/>
    <dbReference type="GeneID" id="20673042"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_41260"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_8_4_1"/>
    <dbReference type="InParanoid" id="W4KMW2"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000172">
        <property type="entry name" value="MFS multidrug resistance transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="23"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW87044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="485" mass="52681" checksum="8AF734A785AF9D93" modified="2014-03-19" version="1">MQQPTVSAEKQYSVFTQHEKWFLVGTASVAGVFSPLTANIYFPAIPTIASQFRKSIEMINLTVTIYMVMQGISPMFWGTLSDRWGRRPMILACMIVLSLSCVGLALVPTSAYWLLMLLRCIQAAGSASTIALGAGVIADIASPSERGGLFGLFSMGPMIGPCLGPVIGGGLAQGLGWRAIFWFLCISSAACALVILLLLPETLRSLVGDGSIVPSAFYRPLIPIIGKSRQPTAPNNRPLPKPFANPLRLFTYPDIVILLIFNGVLYAVFYSVTTTISSLFADVYPFLDQTDIGLCFLAIGGGMVFGSVITGRFLDRDYAAIKNSMIKKAQSDPEKRDVKDVTKDENFPIEMARLRTMPIYVAVFVACTIGYGWCLKARVSLAGPLILQIIIGYVTNAVMNTIQTLLLDLAPSQGSSITACNNLIRCSLGAALVSVIDLILKAMGPGWTYVLLGGICVAVSPLMWVEIRWGPVWREGRRRRLADRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMZ8</accession>
    <name>W4KMZ8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CPL1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_406937</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541148.1">
        <property type="nucleotide sequence ID" value="XM_009542853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMZ8"/>
    <dbReference type="GeneID" id="20672555"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_406937"/>
    <dbReference type="eggNOG" id="ENOG502SA2G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053902_0_0_1"/>
    <dbReference type="InParanoid" id="W4KMZ8"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048661">
        <property type="entry name" value="CPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038955">
        <property type="entry name" value="PriA/CPL1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21671">
        <property type="entry name" value="CPL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844370" description="Protein CPL1-like domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Protein CPL1-like" evidence="3">
        <location>
            <begin position="238"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW87218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="299" mass="30961" checksum="C17F34A1AAD03BA1" modified="2014-03-19" version="1">MTMGRLLVAAFAVLATALPLAAATDCGSGEFWYENKSCCVKQGTPQAPPSPPSGKACPASGNWYWSSEKSCCLPSSKPPSGNPAPTCPSTHSWSYGDSVCNPNTPRSPSTPSSSDCSSSEFWYSPKGCCLPHGGVPNPPSPPSGSECPTSGWYWGKDQGCCVPHHPPANNPPPQCPGGWDWISNTWKCQPSPPSHPTQPPSTPSGTHKKSRKARAASLCPTGLNACPIANVSGLSSDYECIDTTQELESCGGCLSTGAGQDCTAIKGAWNVGCEQGSCAVYNCMTGYKLSSSGKSCIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4KN85</accession>
    <name>W4KN85_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_437588</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540817.1">
        <property type="nucleotide sequence ID" value="XM_009542522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KN85"/>
    <dbReference type="STRING" id="747525.W4KN85"/>
    <dbReference type="GeneID" id="20674966"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_437588"/>
    <dbReference type="eggNOG" id="ENOG502SFZ4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052375_1_0_1"/>
    <dbReference type="InParanoid" id="W4KN85"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00083">
        <property type="entry name" value="bHLH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="164"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW86835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="269" mass="30132" checksum="F42D4FCDB88EDA1F" modified="2014-03-19" version="1">MEGPLEQIPDHPKSPDFMYDSLNSLDYINYPLAAEPYGLAPLNLSSPLNDYAYIGASYTAGSPARPFTPTHIYPPVLSNLSAGEMSSDSMQSGRTSRGSGTHSPSLATVPRSHRYNPMSVMPPRTSGTRERKRRASKHEDFSDDDDDFQPVQTSNASNEVRREEIRRQRIESEQRRRDELRDGYRRLKDALPVSNQKSSKVSLLDRATTHIKYLEMTQQQLQTRLQQAESETQRLRQVNEALMLGTAEQRHAAAAAAVAAVQQQAPAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNB5</accession>
    <name>W4KNB5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vesicular-fusion protein SEC17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_41610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SNAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540341.1">
        <property type="nucleotide sequence ID" value="XM_009542046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNB5"/>
    <dbReference type="FunCoup" id="W4KNB5">
        <property type="interactions" value="335"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KNB5"/>
    <dbReference type="GeneID" id="20673289"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_41610"/>
    <dbReference type="eggNOG" id="KOG1586">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046329_0_2_1"/>
    <dbReference type="InParanoid" id="W4KNB5"/>
    <dbReference type="OrthoDB" id="9984275at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15832">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000049">
        <property type="entry name" value="Alpha-soluble NSF attachment protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF8">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00448">
        <property type="entry name" value="NSFATTACHMNT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW86875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="32377" checksum="090F02C6657B79E9" modified="2014-03-19" version="1">MPAKSPAQIFLEKADKKANASSGWFSSSTTKWEEAGDLYQQAANSFKLDKLFKEAGDAFAREAECRERCKETNDAANAWWNAAKAYKRGFPDLAIQALTQTITHFTQGGRFRQAADREKEIAQIYLQEQHDLQRACESFERAGDWYAQEDAIATANACFKDAADLHADLEQYPAAIARYEQVADHSLGSALTKYSVKEYWLRALLCSLAMQDPVTARRSLTRYSSLDTTFSTTREAKFASALMEAFESGDQEAFTGAVVEFDQVTKLDNWKTGILLKIKRGIQDEPGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPY9</accession>
    <name>W4KPY9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_31375</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540295.1">
        <property type="nucleotide sequence ID" value="XM_009542000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPY9"/>
    <dbReference type="FunCoup" id="W4KPY9">
        <property type="interactions" value="316"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KPY9"/>
    <dbReference type="GeneID" id="20670059"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_31375"/>
    <dbReference type="eggNOG" id="KOG1505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041844_3_1_1"/>
    <dbReference type="InParanoid" id="W4KPY9"/>
    <dbReference type="OrthoDB" id="189226at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="5">
        <location>
            <begin position="126"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW87460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="420" mass="48116" checksum="B827507B55564F5C" modified="2014-03-19" version="1">MPTGLYVKKITERPPKNWAQTLNAIAFVVVFNFGCLMVNASQFAILLPLKLLPFEWASRWYDSGIRYSKGAFGALLILMCQWFAPTRLVVTFEQEGPGAFSEDEFARLVVKDKKGRVTGINLPLKSVLIANHQVYADWWYAWTLTYFSGTHRDVFIVLKKSLKWVPVVGWGMQFFNFIFLARSWASDRLYLVKELAFLGRHAEQQDTPFTFILYPEGTLVSKDTRPISKKFADKIGIPDMTHTLLPRSTGLHYSLRALAPRIPALQLVDITVAYPGIPLLGYGQEYYTLRSIFFDCIPPPSVHIHIRRFDVAKEVPIGNIFTSNSNGLSNDSAATTILEAEVPEVEREVFDLWLRERWVEKDRFMQRYLDTGTFSSHPKTQPPVIIPLQLRHRREVLDAFCFFVPAIAGFVWSKVRDIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W4KQ87</accession>
    <name>W4KQ87_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_447961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541706.1">
        <property type="nucleotide sequence ID" value="XM_009543411.1"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KQ87"/>
    <dbReference type="GeneID" id="20675811"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_447961"/>
    <dbReference type="eggNOG" id="KOG0472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001714_0_0_1"/>
    <dbReference type="InParanoid" id="W4KQ87"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF270">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="1165"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="765"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="937"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1072"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="712"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="866"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="945"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1072"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1107"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1134"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1154"/>
            <end position="1163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW87849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1591" mass="171771" checksum="85AF320A8B6AE209" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4KQJ9</accession>
    <name>W4KQJ9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Prenylcysteine lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_308119</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prenylcysteine oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541549.1">
        <property type="nucleotide sequence ID" value="XM_009543254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KQJ9"/>
    <dbReference type="STRING" id="747525.W4KQJ9"/>
    <dbReference type="GeneID" id="20669546"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_308119"/>
    <dbReference type="eggNOG" id="ENOG502QSHJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021176_0_0_1"/>
    <dbReference type="InParanoid" id="W4KQJ9"/>
    <dbReference type="OrthoDB" id="437369at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001735">
        <property type="term" value="F:prenylcysteine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030327">
        <property type="term" value="P:prenylated protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030328">
        <property type="term" value="P:prenylcysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010795">
        <property type="entry name" value="Prenylcys_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017046">
        <property type="entry name" value="Prenylcysteine_Oxase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944">
        <property type="entry name" value="FARNESYLCYSTEINE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944:SF0">
        <property type="entry name" value="PRENYLCYSTEINE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07156">
        <property type="entry name" value="Prenylcys_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036292">
        <property type="entry name" value="Prenylcysteine_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845642" description="Prenylcysteine lyase domain-containing protein" evidence="9">
        <location>
            <begin position="17"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Prenylcysteine lyase" evidence="10">
        <location>
            <begin position="157"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="515"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW87680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="570" mass="62494" checksum="CAB7EBAD6F6D623F" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4KRM8</accession>
    <name>W4KRM8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transport protein particle component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_307952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541593.1">
        <property type="nucleotide sequence ID" value="XM_009543298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KRM8"/>
    <dbReference type="STRING" id="747525.W4KRM8"/>
    <dbReference type="GeneID" id="20669540"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_307952"/>
    <dbReference type="eggNOG" id="KOG3316">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076409_0_0_1"/>
    <dbReference type="InParanoid" id="W4KRM8"/>
    <dbReference type="OrthoDB" id="941624at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF0">
        <property type="entry name" value="GEO08327P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="26024" checksum="7126466496742957" modified="2014-03-19" version="1">MNTSTSSSSSSLSLLADPLPRSMDGPAMDYFLIEVVQTLRHSSSIAAARAKKVEEEMIASGLITAPPPPPPTLKVKKEVQRESLGSIVSQTQNISGKVAIDEEEEGIRARLEAIGLHVGANITERLCHDRPVFTDTLDIIKFICKDLWAICWDKQVDNLRTNHRGVYVLQDNTFKPISRFSSWEGRPDATRRARLYVAMSAGILRGALARLGIQAMVVPEVNLPQCTFQVKLPKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4JP85</accession>
    <name>W4JP85_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_331281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552800.1">
        <property type="nucleotide sequence ID" value="XM_009554505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JP85"/>
    <dbReference type="GeneID" id="20671644"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_331281"/>
    <dbReference type="eggNOG" id="ENOG502SQKR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052397_0_1_1"/>
    <dbReference type="InParanoid" id="W4JP85"/>
    <dbReference type="OrthoDB" id="3164835at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="14"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="308" mass="34657" checksum="665D8AE8DBFED69F" modified="2014-03-19" version="1" fragment="single">IKDALPPFNQQANSDLILRSSDHVDFHVHKLILSIASPIFEDMLSIPQTSQSVDEHRDGLPIVMLEEDAQMIDFMLRMIYPVPSPVITKLDDLRFVLGPSQKYLFSIYEGFAEESLEKALKWEPISVYVLACKYKYPGAAAKAAEASLSLPLTTPSQYLDDICGEQYHRLLLYRQKCVAATTDVVSSTSWFQPIPTTVFENSATCGCYTQAQEPSASQKRWYGPSYLWTYLTRVGLALRETPSSQCIIADKGDDLNKVFSCGHRGYSFPGYKDTTKGFTQFCQLLVEKVNRAVAQVNIDLYFLSSARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPC6</accession>
    <name>W4JPC6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_39442</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552488.1">
        <property type="nucleotide sequence ID" value="XM_009554193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPC6"/>
    <dbReference type="GeneID" id="20672496"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_39442"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_12_1"/>
    <dbReference type="InParanoid" id="W4JPC6"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF7">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="10"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW75383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="505" mass="55609" checksum="54EE7E0678048968" modified="2014-03-19" version="1">MYTIYNPYIIGAVSTMGGLLFGLDISSVSAFLAIDSYQDYFNHPSDIVQGGITAAMPGGAFFGANIAGHVSDRFGRKPSIIFATIFWIIGCILSCAAQNVGMLIVGRFVKGICVGWCSSQVPVYLAEQAPKAIRGRLVSCQQFAVTIGILVMFYLSYGCSFIPGPTSFRLAWGLQMIPGFLLAVGMLFLPESSRWLAAHGRWDEAENVIARIHNQPLDAPLVAYEITELREAMRLEKEAPKVTYGDMFGKRLRSRTIAGISCQLWSQLVGMNVMMYYIVYVFQMAGLSGNSNLISSSIQYIINFVMTIPAILFVDKWGRRITLLTGSALMAGFLFAVAGLLAAHGHYVDSVDGNENIRWTITGAPSKGVIACSFLFVASFAVTWGPVSWLYIAEIFPLPVRANAAGLATSTNWIMNFALAFFVPPAFRNIQWKTYIVFAVFCVASWVQVFFTFHETKGRALEDISELFESGASPFSKRRTAKMYDSQEKAAHHSTADVHHDKDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPG8</accession>
    <name>W4JPG8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_456036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552847.1">
        <property type="nucleotide sequence ID" value="XM_009554552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPG8"/>
    <dbReference type="GeneID" id="20676691"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_456036"/>
    <dbReference type="HOGENOM" id="CLU_2109365_0_0_1"/>
    <dbReference type="InParanoid" id="W4JPG8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="115" mass="12665" checksum="FF594A5DE27F8A0E" modified="2014-03-19" version="1">MQNLGAPIGSEAQTACPFCLGVWERDLSTKQQADRELPHVLIHEACAHPSTISNPEFDSSSHGAPPTRSIRLRPTSDRRRDPPNLRPTAPHELTQARMPGAEHTLSHPPSPRPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQJ5</accession>
    <name>W4JQJ5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 12 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gh12.3</name>
        <name evidence="4" type="ORF">HETIRDRAFT_144650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552606.1">
        <property type="nucleotide sequence ID" value="XM_009554311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQJ5"/>
    <dbReference type="STRING" id="747525.W4JQJ5"/>
    <dbReference type="GeneID" id="20667047"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_144650"/>
    <dbReference type="eggNOG" id="ENOG502RXZE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051064_0_1_1"/>
    <dbReference type="InParanoid" id="W4JQJ5"/>
    <dbReference type="OrthoDB" id="95118at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF9">
        <property type="entry name" value="XYLOGLUCAN-SPECIFIC ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844945" evidence="3">
        <location>
            <begin position="17"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW75161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="251" mass="26853" checksum="2173270F4981425D" modified="2014-03-19" version="1">MFLPLITLTLPILALAAPLSRRLDTSSYCGHWDTIPAGSYTVLLDQWGTKGATGQSCAQLTSLSGSNLAWVTDWTWSGGNGIKSYTNVQLDKGVNQQLSAIKSMPSAWSWKQTTTGKVVADIAYDLFTSTSVGGSNANEIMIWLANINAGPISYNWNADGTAKPVATGVSIEGHTWDVYHGSNNANPVWSFLPTSNAQITNFSGDIYSFFKYLISKQGLPSSQYLKTAQAGTEATSGSAGLTTTRYSLAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQL2</accession>
    <name>W4JQL2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_246005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552795.1">
        <property type="nucleotide sequence ID" value="XM_009554500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQL2"/>
    <dbReference type="GeneID" id="20669098"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_246005"/>
    <dbReference type="HOGENOM" id="CLU_143913_3_0_1"/>
    <dbReference type="InParanoid" id="W4JQL2"/>
    <dbReference type="OrthoDB" id="3044295at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844018" evidence="1">
        <location>
            <begin position="23"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="97" mass="11374" checksum="FEB932BA5734CE54" modified="2014-03-19" version="1" fragment="single">QILEFFFIKLALFWLQIEVIVAQDLENLVQDLDVFHHVFGKDEDVVHIYGYFPGRDEFFEDHVHHGLEVGKAEEHHRGFVRAQRSDESCLPLVALLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRG2</accession>
    <name>W4JRG2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA-binding S4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_482188</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552873.1">
        <property type="nucleotide sequence ID" value="XM_009554578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRG2"/>
    <dbReference type="FunCoup" id="W4JRG2">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JRG2"/>
    <dbReference type="GeneID" id="20678014"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_482188"/>
    <dbReference type="eggNOG" id="ENOG502QTS9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041823_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRG2"/>
    <dbReference type="OrthoDB" id="3356781at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="136"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="194"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW75456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="334" mass="38283" checksum="A2F83BC0F77C46F6" modified="2014-03-19" version="1">MRDINVYSFAKALPRMSWSRHNLYNLWRRSLGELAKETNFTRTQKTLFQQRWAAKSLVRAYHGDFINEKSFKRWYLPTTLPDVRSRRRVAGDDTLDLNKWAKQDKVVEKGTKVLQEDTENAQLAPVGSMMFAEVERRIDVFIFRACMAHSVYEARRMVVHGDVLLNGQKHQNANTRLAPGDMVSVNPDAIRFLQRQEPKKEDVELETVEPKIEIADESTSASEGEPSAASSSSPSGKPKVPNKPKAKKDSDLTPFNLPPFASPFIFIPAYIEPSFATCSAIYVRHPTARPGYSEVPTPYDADGEVVRLAWEWYSKVRPRMRSKRQLARMPENRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRK9</accession>
    <name>W4JRK9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_461338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552915.1">
        <property type="nucleotide sequence ID" value="XM_009554620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRK9"/>
    <dbReference type="STRING" id="747525.W4JRK9"/>
    <dbReference type="GeneID" id="20677159"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_461338"/>
    <dbReference type="eggNOG" id="ENOG502SVH8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018408_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRK9"/>
    <dbReference type="OrthoDB" id="5569250at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="438"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW75506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="783" mass="88386" checksum="7A51AACC568CC06E" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRL0</accession>
    <name>W4JRL0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartic peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_106390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551981.1">
        <property type="nucleotide sequence ID" value="XM_009553686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRL0"/>
    <dbReference type="GeneID" id="20666160"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_106390"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_8_2_1"/>
    <dbReference type="InParanoid" id="W4JRL0"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="2">
        <location>
            <begin position="42"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW75720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="438" mass="46799" checksum="6ADB6476CE12BE91" modified="2014-03-19" version="1">MSAPTSRSSTAAGGELAPFVLDFDVKRSVSGIPAIDRDDVVYLANVTVGGQPFLVQLDTGSADFWIHKREGMQVSKQTEQRVKIEYGTGWVSGNIAFAPFTVGDFQVPSQAFINVDASADLDDLDGIWGLGFDRASNIHSASSSSLTSHSPDSSTLTPLTNIFAQTPMTPNVLTLDLSRSASGDASSSSSGTFTIGPYMPAARFEGVPHVPVAETSGGWEVALDGMRVNGQPFDLNTSMSALATAVKKRWRWDKRQGQGGQNINVLLDSGTSFALVDDAAADFIYGGMQGAKSCVIDGGKYWFVPCLATANVSFGFGGRFFSVHPLDLTLVMDAEDLDGEPRTVCAGVFTGKSSAPDIRDEPLWVLGDAFMRNVLTAFHFGRETLEGGFDGAPTVQMASKTDQAAVATEFRRARWEALRGRPKMMDPVDVDCANVPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRS2</accession>
    <name>W4JRS2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_391201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552974.1">
        <property type="nucleotide sequence ID" value="XM_009554679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRS2"/>
    <dbReference type="GeneID" id="20672472"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_391201"/>
    <dbReference type="eggNOG" id="ENOG502SJDY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011073_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRS2"/>
    <dbReference type="OrthoDB" id="3258324at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW75576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="52438" checksum="5AB057E2DA5BFE35" modified="2014-03-19" version="1">MTPDPLDTTDELSFLESPALQLAAYYASMRFKANISLVSKRWNAFVKVYMYEFVWISRAVQAKALAHTLLLEFVEGLGSSGRFIRRLHIETPVLERCSPADLQTILEYSPQLTIYTDHQSIQRNRYDIVPDPRCSPERLLSLLAHPNSTLRRLAWTSYDDVPFHLRMSPLQDMPTRRLEYLELSSCSPNFHALFSESADLASAAMRVSLPALRSLKVSLDNGMFAVLASWDMPALRNLSVVSADFSYTGKGFFRFFAAHGAALQQLELGHSSSLIEEHYLTTHPRRHRQLHGTDVDADEGREPLSLARWCPNLRELICSADAEWHWESPDWIAPHILLPRHPRLTMIAIRDIDARITSALDMTEGGGIHAAAAGAAGDDTAFFPLLEQMSSLLLRDAFPALKYVRDLSVESHEMRAQYPHPAVAKFWRRVLRRCQERDVWLEDYTGVNITPSALKRASHMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4JS70</accession>
    <name>W4JS70_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_53389</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551181.1">
        <property type="nucleotide sequence ID" value="XM_009552886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JS70"/>
    <dbReference type="FunCoup" id="W4JS70">
        <property type="interactions" value="370"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JS70"/>
    <dbReference type="GeneID" id="20678255"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_53389"/>
    <dbReference type="eggNOG" id="KOG1110">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042860_1_2_1"/>
    <dbReference type="InParanoid" id="W4JS70"/>
    <dbReference type="OrthoDB" id="547796at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF72">
        <property type="entry name" value="NEUDESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="60"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW76407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="166" mass="18508" checksum="7DEFBF97D1CEE683" modified="2014-03-19" version="1">MSSFALSTPINTALVLYIVYYVQRVIFPRTSIPKEAPAEFKAGYSWMPKAHPPTLLFTTYTPNTLEPFSGRDGGRILLAIAGTVFDVTAGRNFYGPDGMYGNFAGRDASRGMAKQSFDIEMLTPIDQPLDKLEDLTPDEIENMKGWIDHFSNKYIICGRLVENDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4JS83</accession>
    <name>W4JS83_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_442224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552001.1">
        <property type="nucleotide sequence ID" value="XM_009553706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JS83"/>
    <dbReference type="GeneID" id="20675426"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_442224"/>
    <dbReference type="HOGENOM" id="CLU_1532762_0_0_1"/>
    <dbReference type="InParanoid" id="W4JS83"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW75741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="175" mass="20170" checksum="7D27A1297D522241" modified="2014-03-19" version="1">MRGHRVARYKLAISYQELHGVSLFSHLMDHLRPLPQIRPSTEGPMVQTMSRLVQERGSLLLIRGTRGPAIVNLPLRPIRHRRLVSSTPDRTRHCPGMPLGHFLMSLRKRGRVGRNMINTKRSIRMSKPLELNVMTLLWGPRPKPPPQTVFLLQAEVVLNLDLHRPSHLNFHLLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSG0</accession>
    <name>W4JSG0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 subunit A</fullName>
            <shortName evidence="6">eIF3a</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 110 kDa subunit homolog</fullName>
            <shortName evidence="6">eIF3 p110</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Translation initiation factor eIF3, p110 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TIF32</name>
        <name evidence="9" type="ORF">HETIRDRAFT_480612</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
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    </evidence>
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            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
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</entry>
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            <taxon>Bondarzewiaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
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                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
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                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
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                <person name="Karlsson M."/>
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                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552303.1">
        <property type="nucleotide sequence ID" value="XM_009554008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JT67"/>
    <dbReference type="GeneID" id="20668674"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_223481"/>
    <dbReference type="HOGENOM" id="CLU_2446636_0_0_1"/>
    <dbReference type="InParanoid" id="W4JT67"/>
    <dbReference type="OrthoDB" id="2686513at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="90" mass="9954" checksum="4E504A0414692C2A" modified="2014-03-19" version="1" fragment="single">YRVMAFVNVVNVLTFYDILRGFLSTFASCISITMMSRLILNLHDASSLLPSTHRATQSMAFASIHGPVNSDMLPSLRSADADDDQDDDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTI1</accession>
    <name>W4JTI1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hydrophobin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hbf2</name>
        <name evidence="8" type="ORF">HETIRDRAFT_65822</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551197.1">
        <property type="nucleotide sequence ID" value="XM_009552902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTI1"/>
    <dbReference type="GeneID" id="20678755"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_65822"/>
    <dbReference type="eggNOG" id="ENOG502QUR8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_930844_0_0_1"/>
    <dbReference type="InParanoid" id="W4JTI1"/>
    <dbReference type="OrthoDB" id="4225815at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844949" evidence="7">
        <location>
            <begin position="23"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="37"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW76410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="299" mass="33786" checksum="4BA747A043CCDEA5" modified="2014-03-19" version="1">MFSRISAVSAVSFLTLAVVVSAGPWGSMKPEYKPVPAPVPTPEYTAAPAYTTTPYKDDYKEPEYPKTTAYAPAYPKDDYPSPAYPTDDYSSQEYPKDDYKYPEPVKDEYEPKKEEYKSDYLDDYRRRDYAPEPPKGYPVNDKPYADPKKEYDPKKEYDPKKPYDPKKEYDPKKPYDPKKEYDPKKEYDPKDKDYKSVKDVKDEYAHDIYNEEEHKMQCNSGPVQCCNTVEEARSEGAAKALGLLGIVLNDLNTPIGLNCDSLNAAGFGSGSNCVSQTVCCDRTEFGGLGINCSPINIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTU4</accession>
    <name>W4JTU4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycoside hydrolase family 5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_411880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551831.1">
        <property type="nucleotide sequence ID" value="XM_009553536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTU4"/>
    <dbReference type="STRING" id="747525.W4JTU4"/>
    <dbReference type="GeneID" id="20672977"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_411880"/>
    <dbReference type="eggNOG" id="ENOG502SISK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031875_1_1_1"/>
    <dbReference type="InParanoid" id="W4JTU4"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000130">
        <property type="entry name" value="Endoglucanase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF13">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="5">
        <location>
            <begin position="72"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW76973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="475" mass="55359" checksum="4B300A72032CABA7" modified="2014-03-19" version="1">MSFLRVLGTSVVADSGSEVVLRGAGLGGWMCMENFISGFPGSEFQVREALAEVLGVQKAELFFEKYLENFFTASDASFFRSLSLNCIRIAINYRHFESPMNPRHLRPNAFTHLDRVIRLCAAEGIYTIIDLHTAPGGQNGGWHADHGTHLANFWRHKDFMDSAVWLWERLAERYKDEPWIAGFNVLNEPADPSAKQLILFYDRVVRAIRAIDTRHILFLDGNTYAADFSAFPANVKERWGENVAYSIHDYSVFGFPKGGIYERTEEQKEKIKRGYIRKRAWMDKRGLCVWNGEWGPVYARKEYEGENTDTINERRYMVLQDQLNLYQEDRLSWSIWLYKDIGFQGMVYVSPKTLYMQRLKPFLEKKYRLAVDSWGADDAGVQHVFRPIVDFIKEAVPREEDCRLYPWPNWSVEERVSRLARATLIGEFLVKEWAEYFRGMDETQLEEMAKSFHLDNCTKREGLNRVLREHAQQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTV8</accession>
    <name>W4JTV8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Elongation factor methyltransferase 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_105796</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">TC 32-1</strain>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="280" mass="31546" checksum="BEA970622C8EAF8D" modified="2014-03-19" version="1">MSNIEDEPGLSLDSIFEPERPPSPDPTFSTYTRKRALNKFDWETIEIRLVGSHPLWGHYLKVTHIPSFSWNASRSFASYLDEHQELYHDRCVLELGAGGGLPGIVAVKNGARKVVLTDYPDTALIDNLAYNVERNTDSTARSKADVQGYIWGHAVAPLLSPLQDTSKTSASQQKFDLIIMSDLVFNHSQHDALLKTCALCLSSTPSPPPVDMSPCLIVFYTHHRPHLAERDLDFFRKAHDQGWTCEEIITERFPPMFPDDPGDEEVRATVHGWKLTRHAP</sequence>
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            <strain evidence="2 3">TC 32-1</strain>
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    </dbReference>
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        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
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            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="150" mass="16757" checksum="6E55C0B778D82D2E" modified="2014-03-19" version="1">MSTVWPPVERNSAGKMIQDSLGLMPDDILADYACQRYTTKFTIMAFWCYTRSSQFLCTKCSKEQKGCSFQPGWMLKDKGKSKGKKKSKVKVAKTLEEPEPSCPTKKHKGKLEVLEAHLGGWAVSDVVLVEDSLNAKDLDMSMLGDFVPNV</sequence>
</entry>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="94" mass="10873" checksum="342C31CB952A7F8D" modified="2014-03-19" version="1">MGVVRGGGEGEREGEGLSKSSSLQILAESFFCFLHCLFFVHVPWYRSFFYYRHLRSRGNRGFSGGCFFVRLFDKSVFRGEVDGFTGRHVCWRSE</sequence>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
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                <person name="James T.Y."/>
                <person name="Karlsson M."/>
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                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
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                <person name="Park J."/>
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                <person name="Salamov A."/>
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                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_009552506.1"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77273.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="86" mass="10063" checksum="A7679129A1EB5662" modified="2014-03-19" version="1">MSSSSSYSTHYPLPWPLFSRLLSTSYNMPRMLLIMVTLKIISYLLINETACLLCVPSSFKCCAHRLLPFSHHMYPYSLRDRDETER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUT1</accession>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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        <property type="term" value="P:chromatin remodeling"/>
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        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <feature type="region of interest" description="Disordered" evidence="6">
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    <feature type="region of interest" description="Disordered" evidence="6">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
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    </feature>
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    </feature>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW77298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2012" mass="207199" checksum="E51E6EE34D8BA299" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUV5</accession>
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        <recommendedName>
            <fullName evidence="5">Phospholipase</fullName>
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        </recommendedName>
    </protein>
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    </gene>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
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            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">TC 32-1</strain>
        </source>
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        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
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        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the phospholipase D family.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
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                <person name="Hogberg N."/>
                <person name="James T.Y."/>
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                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
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        </source>
    </evidence>
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    </evidence>
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</entry>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
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                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
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                <person name="Gonthier P."/>
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                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
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                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
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                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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            <dbReference type="EMBL" id="ETW77498.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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    <accession>W4JVB0</accession>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Asiegbu F."/>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
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                <person name="Gonthier P."/>
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                <person name="Hansson D."/>
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                <person name="Kues U."/>
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                <person name="Lin Y.C."/>
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                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">TC 32-1</strain>
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    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="41912" checksum="7BC98082C88632D2" modified="2014-03-19" version="1">MDSLPYERLDAIVSKMHHFKDLLQIRTLNKTFCALATPRVFREVIVTKHFTSAAVFDEILQNDAIAQSIETITFREGGDHEYAHVQIRDTVPGPKSNLEISLKSLTSSFARIHDLPRLKNLVLSFYREPKLLLQSTILSAILSRPHPLSLSSLALDGLMSLHDSIYDLPSFKGLFGSLSSLMITTKFTGDPKSHSRNAYIRFWEQGIQHSVLGSLSHSLTSFILHSDVDVGIVPRLDFSQATFPVLEFLWLGRILFNAVTHVEDFILQLRLKTRRTKPRQWSHIWDYFAEELKALGTLKVESESHWFEDYSDSDLDDGEPMNYVQLKEGRQGTRYAYSAMEGSPYDDSDARALQKFWCLIHPEDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVD3</accession>
    <name>W4JVD3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_109354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550594.1">
        <property type="nucleotide sequence ID" value="XM_009552299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JVD3"/>
    <dbReference type="GeneID" id="20666434"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_109354"/>
    <dbReference type="HOGENOM" id="CLU_1489205_0_0_1"/>
    <dbReference type="InParanoid" id="W4JVD3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="181" mass="18727" checksum="5ADCF9CE6E85C13B" modified="2014-03-19" version="1">MASAPTAAGPSPTCPHWPALARPITGPGGGIPDGQRHDVTPCLHSAIRRPWPPSPPPSHAVPALPRRTRTRQPSRGHRTAPACSAHAAQPGVRPHAPPRRMCPLPSQSSSRPRSNSATHLTSVHHRMAVSAGSSPFPAAAAAAADHLGPAPALPGIPSFPLAHLLSFSHMCSSPSDPIHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVR6</accession>
    <name>W4JVR6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_326574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551116.1">
        <property type="nucleotide sequence ID" value="XM_009552821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JVR6"/>
    <dbReference type="STRING" id="747525.W4JVR6"/>
    <dbReference type="GeneID" id="20671255"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_326574"/>
    <dbReference type="HOGENOM" id="CLU_1468342_0_0_1"/>
    <dbReference type="InParanoid" id="W4JVR6"/>
    <dbReference type="OrthoDB" id="10066232at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW77637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="184" mass="20329" checksum="65475B8E5BCF4C70" modified="2014-03-19" version="1">MVLIIEQWGGRIYSEFASCALREQLSLHVTLEILAAEPEYCLNTVVPNCVLRSLIMDAILEPLGSGSITVGGSKRAKRGPLPHTSSDYKDHLLAAQALSKHLDAMGCHHAYIGGFAWSLLGSTRPTHDIDVLIETEDILTVRKTLDSLGIHFAMDTLKLYFVKVGFRSALYSMSIIEFRTIVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVX6</accession>
    <name>W4JVX6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS monocarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_65718</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550531.1">
        <property type="nucleotide sequence ID" value="XM_009552236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JVX6"/>
    <dbReference type="GeneID" id="20678748"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_65718"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_1_1"/>
    <dbReference type="InParanoid" id="W4JVX6"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW77026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="400" mass="44095" checksum="EE6B91B759BB5B13" modified="2014-03-19" version="1">MPSAPPESPVDHQTVAGSVVDHEKGDRDNVGVQPTSDPPSPSEIVPPDGGFDAWITIAGAWLFQFCTFGYINAFGVYQDYYTRTFLTKYTASDISWIGSFQLAMQYFPGVLVGRVFDAGYFHHLCISGSILYVFSMFMLSLVKENQYYQVFLSQGVGMGVAQGMLFLPSLTIVPHHFRRRRALATGIVVTGSSAGGIVIPIMLNRLFRSHLGFANGVRIGAAMVAVLLILANLMVRTRLPPKSARSSFSRDDLKRILTDWPYMTAMAGAFCTNLGLFFPYFYMQLWTIEHGIDQTLAFYTLAIVNAGSVGGRLLPTFLADIVGVYNMLLPCMASSAILLWAIFGAKTSAGVIVVSLLFGFSSGACMKLFPLSTFRPFRLTSFSRRFSDPEPPRMPRTEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWX4</accession>
    <name>W4JWX4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Intradiol ring-cleavage dioxygenases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_460312</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549971.1">
        <property type="nucleotide sequence ID" value="XM_009551676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWX4"/>
    <dbReference type="GeneID" id="20677062"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_460312"/>
    <dbReference type="eggNOG" id="ENOG502QWDJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046727_2_0_1"/>
    <dbReference type="InParanoid" id="W4JWX4"/>
    <dbReference type="OrthoDB" id="5238185at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF7">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catechol dioxygenase N-terminal" evidence="9">
        <location>
            <begin position="44"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="8">
        <location>
            <begin position="124"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW77959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="35729" checksum="8F965DFC1FDEF522" modified="2014-03-19" version="1">MSANSTASQPQSNGIPPPKLELPYPDRPEIVTANILKLTELVPDQRTKEVLTALVTHLHQFVQETKLSTEEWTKGMEFLTEVGELCTPLRQEYIMLSDVLGVSALVDTMNNPPLKNATESCLLGPAFTDDAPEVNYGGAIIDGEHGIGNAEYLFLEGRVLTTDGKPIDGAVVETWETDENGLYDVQYNVRDKPNGRGRLRTNSEGKFAFRGVVPLAYPMPDDGPVGKLLRVWNRHNMRAAHVHLIIKAAGFRTLTTQLYPAGDKWANTDVVFGPKKSLVITLKDVQDPEEAAKRGIPNSAPFKLAQYDFVLLSEAEVEAHAATPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWY6</accession>
    <name>W4JWY6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_429185</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550074.1">
        <property type="nucleotide sequence ID" value="XM_009551779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWY6"/>
    <dbReference type="FunCoup" id="W4JWY6">
        <property type="interactions" value="199"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JWY6"/>
    <dbReference type="GeneID" id="20674323"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_429185"/>
    <dbReference type="eggNOG" id="KOG1744">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075666_1_3_1"/>
    <dbReference type="InParanoid" id="W4JWY6"/>
    <dbReference type="OrthoDB" id="10254238at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000014">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10 11" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="13">
        <location>
            <begin position="45"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW78072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="149" mass="15715" checksum="E44846CF622C18E0" modified="2014-03-19" version="1">MAPKPASTAGKAPASSATASKAPAKTTEGSKAAKKTSKTAAAPGEEGKKKRRKVRKETYSSYIYKVLKQVHPDTGISNKAMAILNSFVNDIFERIATEASKLAAYSKKSTISSREIQTAVRLILPGELSKHAISEGTKSVTKFSSAGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>W4JX90</accession>
    <name>W4JX90_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1 6">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_235382</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1 6"/>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550997.1">
        <property type="nucleotide sequence ID" value="XM_009552702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JX90"/>
    <dbReference type="FunCoup" id="W4JX90">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JX90"/>
    <dbReference type="GeneID" id="20668748"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_235382"/>
    <dbReference type="eggNOG" id="KOG0169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002738_1_2_1"/>
    <dbReference type="InParanoid" id="W4JX90"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16207">
        <property type="entry name" value="EFh_ScPlc1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13360">
        <property type="entry name" value="PH_PLC_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037755">
        <property type="entry name" value="Plc1_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="168"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="9">
        <location>
            <begin position="554"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="665"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="516"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="742"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="468"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="516"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="528"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="744"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW77501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="871" mass="97517" checksum="A3B014AFAF8A0895" modified="2014-03-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXH1</accession>
    <name>W4JXH1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alpha-galactosidase</fullName>
            <ecNumber evidence="9">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_39280</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="9"/>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549642.1">
        <property type="nucleotide sequence ID" value="XM_009551347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXH1"/>
    <dbReference type="FunCoup" id="W4JXH1">
        <property type="interactions" value="152"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JXH1"/>
    <dbReference type="GeneID" id="20672490"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_39280"/>
    <dbReference type="eggNOG" id="KOG2366">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013093_2_1_1"/>
    <dbReference type="InParanoid" id="W4JXH1"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000197">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF61">
        <property type="entry name" value="ALPHA-GALACTOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="11">
        <location>
            <begin position="395"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW78243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="501" mass="55200" checksum="81D21A075A14B2CC" modified="2014-03-19" version="1">MSSGLPLAVDGRGLPSEKQREGCPAPSLPFPPALLYPSAPPHVSSPPARAARYAAMLLSAALLSLSLALALRAPPFRDHTSAPLGAAHALHDRVGKLPAMGYNTWNAYHCAINESIILQTARLVKSLGLADLGYDHINLDDCWAEKNRSADGAVLANKQDFPSGLKNLTDEIHALGLKAGIYSDSGWFTCQLYPGSFQHEEQDARTFVDWGFDYLKYDNCAVPFDDVLRQGMVGKYERMADAIQKVAKETGAPPLLFSLCQWGREQPWLWAREFGQSWRTTDDIGPHWDAMSSIINQNSFYSWASDFYGHNDMDILEVGNGDLTYDEAKSHYTAWALMKSPLLIGTDLTSITAETLEILSNREIIAINQDPVVGTGLTPFRWGRNPDWTNDYTYPAQYWSGRSQNGTVFMLLNVLDEPADMTFSLTESPWIRAGRQYSVRDLWAHTDNGTAVRNFTAAAVPAHGVVALLLRDAGDEPAGLSPPCAVIEWCMAPNGTRYDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXW4</accession>
    <name>W4JXW4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH TFE/IIEalpha-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_126621</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIE alpha subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549945.1">
        <property type="nucleotide sequence ID" value="XM_009551650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXW4"/>
    <dbReference type="FunCoup" id="W4JXW4">
        <property type="interactions" value="352"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JXW4"/>
    <dbReference type="GeneID" id="20666949"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_126621"/>
    <dbReference type="eggNOG" id="KOG2593">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035744_0_1_1"/>
    <dbReference type="InParanoid" id="W4JXW4"/>
    <dbReference type="OrthoDB" id="361102at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW77930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="511" mass="57091" checksum="7336570C5D0F0679" modified="2014-03-19" version="1">MITDEDKAALRLLVQYVSRAFYEPKFIVVMDQLARHEVLKDDDLAGRMGLQLKELNKLMAVLEGDRLVQVHRQNELKEGAQRSVGRQYFYVDFQRFCNVVKWRVSEMRRRIDTGLRNELDNKGYICPRCHKSFAPLEVDKLMDFERGAFICDVCHAELIDNDDAESVRGSQDRMQRFNYQMRFIREGLRKSEEMVLPAFDVVQFISKNLASDAASQKGSGEPGRGLKVAGSYGEKRKDEGVGIVISTDKDEETVRRERDAEAAAKRQQNAMPSWHLKSTITGDLTALGVKENALQVGSAVNGALVNGHEANGFDESLKGLGRVGGSLNLSAIQPSVDMAVEDVKPDVKQIHEVDYYDHYYASLANSAAPSAQNTPSADFAFTTDDFDEDRKPDVDYLDSLNEYRKRSRSREDEGDAERKIAKTANGVNGVVNGVNGHSGVNGSAMEPEGVSRIGDEEAIEDDPIMLGGCLCPLLFFNGEPIAFSHVTEEHQELMTPEEYTAYFDVYQARAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXW6</accession>
    <name>W4JXW6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_109022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550393.1">
        <property type="nucleotide sequence ID" value="XM_009552098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXW6"/>
    <dbReference type="GeneID" id="20666401"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_109022"/>
    <dbReference type="HOGENOM" id="CLU_2758090_0_0_1"/>
    <dbReference type="InParanoid" id="W4JXW6"/>
    <dbReference type="OrthoDB" id="10532032at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="70" mass="7920" checksum="93B4A3A5577A0591" modified="2014-03-19" version="1">MTTSLGRLTKAVDGIKLIVDYINDYQLTEQAQVRTPQYLVRAAIIKEFEAVAENLNLPSSDPIRQSHLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYP0</accession>
    <name>W4JYP0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_243347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="286" mass="31985" checksum="D19D4CE719E84921" modified="2014-03-19" version="1">MPTEHRTTDTVRVHMCTHPHQRTLERCAGTVPRVHKQRPEPLRASPPALAGETTDAGARALSSHYPPTRTRVHDMIMPPAEHRARTHTHIDIDIDTHRRISRTRTEEALLTNDLSAAQERADSETRARTLVPTACTVFTAHVHDQRLVARLDTEIADAAQAPRRCTDMSIQYLSIDPPAARPSPSNAVQRAKFREIYPPPFSPTLLRRAAPDYGAARHLRTMTHCVTARAHTISPSTEHLSESTKNANDREELEFSAGQPRPARPRLERQSRGCPARTPSRGRGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZ61</accession>
    <name>W4JZ61_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lipase, class 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_104169</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549122.1">
        <property type="nucleotide sequence ID" value="XM_009550827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZ61"/>
    <dbReference type="GeneID" id="20665972"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_104169"/>
    <dbReference type="eggNOG" id="KOG4569">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032957_9_1_1"/>
    <dbReference type="InParanoid" id="W4JZ61"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF25">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004843916" evidence="6">
        <location>
            <begin position="22"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="7">
        <location>
            <begin position="103"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW78822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="300" mass="31007" checksum="B59EF78A00173E76" modified="2014-03-19" version="1">MAASILTVALFAATLIDVSLGAAVTKRQSVTALSQAQISAFKPYTHYASTAYCTPSTTLTWTCGANCDANSGFLPTASGGDGAATQYWYVGWDASESTVIVGHQGTQASKIIPVLTDGSFFLTQLDSTLFPGLNSSIEVHNGFAASQARSAADVLAAVQSTLSAHSSNSVTVVGHSLGAAIALLDSVYLPLHLPSTVTVKTVGYGMPRVGNEAFADYVDAHLHVTHINNKVDPVPIVPGRFLGFVHPAGEVHINDDGSWDSCPGQDNTSSDCIVGAEPSLLDGDSSDHSGPYDGVTMGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZV0</accession>
    <name>W4JZV0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_419867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548944.1">
        <property type="nucleotide sequence ID" value="XM_009550649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZV0"/>
    <dbReference type="GeneID" id="20673610"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_419867"/>
    <dbReference type="HOGENOM" id="CLU_2503865_0_0_1"/>
    <dbReference type="InParanoid" id="W4JZV0"/>
    <dbReference type="OrthoDB" id="2449121at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="92" mass="10575" checksum="09D78F9D34056FD2" modified="2014-03-19" version="1">MPGVEYKHSYCKIYKVKFEDAKKVAQQCLNKCPVNIDSDAILGLITFCFFRSKNWPPPFYRGKFHKGHFLTPFASLSPNLNSVCPKKFRLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4K045</accession>
    <name>W4K045_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_453598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549366.1">
        <property type="nucleotide sequence ID" value="XM_009551071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K045"/>
    <dbReference type="STRING" id="747525.W4K045"/>
    <dbReference type="GeneID" id="20676398"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_453598"/>
    <dbReference type="eggNOG" id="ENOG502SE0S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006928_0_0_1"/>
    <dbReference type="InParanoid" id="W4K045"/>
    <dbReference type="OrthoDB" id="3262497at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="842"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="929"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
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            <end position="615"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="650"/>
        </location>
    </feature>
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        <location>
            <begin position="657"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="704"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="719"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="868"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="887"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="934"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1080"/>
            <end position="1093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1110" mass="116417" checksum="4CBDF8CBE8B606DE" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0U5</accession>
    <name>W4K0U5_HETIT</name>
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        <recommendedName>
            <fullName evidence="4 11">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_155984</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
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        <property type="protein sequence ID" value="ETW78955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549239.1">
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    </dbReference>
    <dbReference type="STRING" id="747525.W4K0U5"/>
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    <dbReference type="HOGENOM" id="CLU_010510_0_0_1"/>
    <dbReference type="InParanoid" id="W4K0U5"/>
    <dbReference type="OrthoDB" id="362021at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0051301">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Condensin_barren_su2"/>
    </dbReference>
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        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
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    </dbReference>
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        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Condensin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="8 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="206"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="362"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="549"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="652"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="728"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="658"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
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            <begin position="733"/>
            <end position="742"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR017126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW78955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="833" mass="92154" checksum="468335FB51EFF322" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1S5</accession>
    <name>W4K1S5_HETIT</name>
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        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_124369</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 35 family.</text>
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    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009550023.1"/>
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    <dbReference type="AlphaFoldDB" id="W4K1S5"/>
    <dbReference type="GeneID" id="20666868"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_124369"/>
    <dbReference type="eggNOG" id="KOG0496">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_005732_2_0_1"/>
    <dbReference type="InParanoid" id="W4K1S5"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
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            <end position="482"/>
        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW79762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="921" mass="101080" checksum="2061B88FCAF8AFD9" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
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        <name evidence="1" type="ORF">HETIRDRAFT_171604</name>
    </gene>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="20668355"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_171604"/>
    <dbReference type="HOGENOM" id="CLU_541903_0_0_1"/>
    <dbReference type="InParanoid" id="W4K232"/>
    <dbReference type="OrthoDB" id="2884925at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="ETW79873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="610" mass="68146" checksum="22BF11B0C545BD89" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2B2</accession>
    <name>W4K2B2_HETIT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <lineage>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="747525.W4K2B2"/>
    <dbReference type="GeneID" id="20672275"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_386381"/>
    <dbReference type="eggNOG" id="ENOG502SN7W">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000030671">
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    </dbReference>
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        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="335" mass="36306" checksum="5F6F84D83F2F8F40" modified="2014-03-19" version="1">MSGPRLERSLRRARCLCRRASHPSSIVENSIPRLHTPCVSQRPHALRHHSSTALRLSPLIDPLTGHDSDPHTQPESSPDTPPEISDTEWDLRTGRAIDLLRSTLPTFFNTGLVTRAPPAVSPSWNLTGADLARDSMPTTAKAHGDDSKSIYSPNIYFSYTPPHALPSPFPRTLHVEGFPLYIASSVFIRHTLNALYSDLSVDVHKLSVNPSRSSRAPHTPSSGLEQDSARNRTLRREKSLFVGFTVSGSARVTGSETKWEVNSTYTFSPVSGLIHKHTIDSIQPAPHEAVFDLLRAALAKLRIGVAEPGSGVGVGGAACRTHAKGSGIGDEKGCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2B4</accession>
    <name>W4K2B4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549483.1">
        <property type="nucleotide sequence ID" value="XM_009551188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2B4"/>
    <dbReference type="GeneID" id="20677831"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_478643"/>
    <dbReference type="HOGENOM" id="CLU_2085133_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2B4"/>
    <dbReference type="OrthoDB" id="3211970at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="117" mass="12828" checksum="D5D92FB3C7744BB5" modified="2014-03-19" version="1">MDVPTWRILVFSAPGETDLANLGHHSARVSVAKPFEDGAGLNHSETDSMDDQSDESSSEDNEHEARNDCSLLAPLIEAHTVYELTTYDLREDLLSLGLAEVSGRIALGTRFGQIRMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2J3</accession>
    <name>W4K2J3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_453041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548572.1">
        <property type="nucleotide sequence ID" value="XM_009550277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2J3"/>
    <dbReference type="GeneID" id="20676335"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_453041"/>
    <dbReference type="HOGENOM" id="CLU_078256_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2J3"/>
    <dbReference type="OrthoDB" id="3251271at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="277" mass="30348" checksum="56B15E17AD0354AB" modified="2014-03-19" version="1">MTGKSISTGTLNLRFMQNARRNEELAQAEAASKVQIQDESFWEVSSAVREAWGIAAGAQKDSHLAVVHEASYIPFLFPSASTSADTTDQPKLRGRRTWNKHGKEVTEADTQPKPEDSSASATEDASSTSSRSKPLRHLTSISGMGPPARSTKEGRESKKPTSRPAQTARDVIRESGRVGTDLRSSRTEPTSTHSLSPIPSDTRMFMKPAGVDEPSLNKGRRPPKTEEDGGIVYGARSKEKIPALKRARTERAEVNMFSGDVRDEEGKSRKKKKKKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2X4</accession>
    <name>W4K2X4_HETIT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_48849</name>
    </gene>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547929.1">
        <property type="nucleotide sequence ID" value="XM_009549634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2X4"/>
    <dbReference type="STRING" id="747525.W4K2X4"/>
    <dbReference type="GeneID" id="20678087"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_48849"/>
    <dbReference type="eggNOG" id="ENOG502S3G3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_32_0_1"/>
    <dbReference type="InParanoid" id="W4K2X4"/>
    <dbReference type="OrthoDB" id="128646at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW80167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="126" mass="14533" checksum="4B417B1639358E1F" modified="2014-03-19" version="1" fragment="single">MNDRIITPIRLNVKVSNRSQYAGAKATIDSACEGVIVNKTWVRRHRFPTYTLNNPIRVRNVDDTINKAGLIRSALDVNLTIWDIKGQTHTERVQMFISNLGKDDLILGTDWLKYHDPSIECRRREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3Q0</accession>
    <name>W4K3Q0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_46276</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009548650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3Q0"/>
    <dbReference type="FunCoup" id="W4K3Q0">
        <property type="interactions" value="213"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K3Q0"/>
    <dbReference type="GeneID" id="20677184"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_46276"/>
    <dbReference type="eggNOG" id="KOG3662">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011607_0_1_1"/>
    <dbReference type="InParanoid" id="W4K3Q0"/>
    <dbReference type="OrthoDB" id="5977743at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF4">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="63"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW80437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="388" mass="43472" checksum="3A2472F240B66D61" modified="2014-03-19" version="1" fragment="single">MNTKRYTFARALGSDILVNGLRLFWVTLVIWGEFGVFFYSLSSCRWPDKLFHRPKSSPRASHILLVADPHVLPDTHSRAHTLVQRFRDIHLRKSWAAVRRLRPHTIFFLGDMLASGGAIKDDDEYETYVRKFKNTFPVDPDIEVRYLPGNSDVGLGEINSFTKHVRERYMDHFGALNQRISVANSTLVLLDAPGLVNEDYLRAGSGVSFDHWTPLKDGPIEFVTAVATDHEQGPIILFSHIPLHRAESRACGPLRERGTIRRGVGHGWQSSLGKQTSVFLLQSLKPVVIFSADDRDYCDITHVIASNVSSASSSAQRAEIHEITVKSISLAPQITRPGFQLLSLLPMDPDTSTDVPTFAHTPCFLPSAHHTYTGLYIPFSFLTSIALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4J8</accession>
    <name>W4K4J8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pseudouridine synthase RsuA/RluA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_45339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546920.1">
        <property type="nucleotide sequence ID" value="XM_009548625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4J8"/>
    <dbReference type="STRING" id="747525.W4K4J8"/>
    <dbReference type="GeneID" id="20676375"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_45339"/>
    <dbReference type="eggNOG" id="KOG1919">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_11_0_1"/>
    <dbReference type="InParanoid" id="W4K4J8"/>
    <dbReference type="OrthoDB" id="428658at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="1">
        <location>
            <begin position="32"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="292" mass="32380" checksum="365A157FAC554A65" modified="2014-03-19" version="1">MPLRKQLSALARLSNARASSSLRSVLYVDRAVIVLNKPSGLVAQTSLKLTQLLIILPDLQHEYDLSTPPYPVHRLDKNTTGALVLAKTTHAARELSRQFKSRAVIKDYLALVRGGENMFTKKEGVITNPIQVDRDGRVSVSTQDGKPALTTWELLGSSPRVPLSLLRMQLHTGLKHQLRVHTASVLKAPILGDTLHGAEAIAPKVSSLVPEECMFLHASSVSLFRYRREGPSKRFRLKVVAPLPISFIRVCRDVGIELEEAIIQGGVYMDDVRVESGEVHTKEVRNRITGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4U6</accession>
    <name>W4K4U6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_101911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547523.1">
        <property type="nucleotide sequence ID" value="XM_009549228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4U6"/>
    <dbReference type="GeneID" id="20665810"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_101911"/>
    <dbReference type="HOGENOM" id="CLU_1396492_0_0_1"/>
    <dbReference type="InParanoid" id="W4K4U6"/>
    <dbReference type="OrthoDB" id="3166034at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="195" mass="22516" checksum="6167C90B96CD9026" modified="2014-03-19" version="1">MDTNEEHRLTTLREELARARSQLDAERTQRALDEAAAREQSDRDAADRHRAMMEQMNDLTTLLRGQRDELTSHRERMEDSIVEDSRRTAEKDARLAALESDLSRIRRDQATESTRLEEARAAAATKPSDGARWQAVETVLQEIRQRSDEHREMINDFSHQMREESARRHEQLQQMLLSSASARESVSFSDPGSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4Y1</accession>
    <name>W4K4Y1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcriptional coactivator p15 (PC4) C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_46047</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transcriptional coactivator PC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546937.1">
        <property type="nucleotide sequence ID" value="XM_009548642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4Y1"/>
    <dbReference type="STRING" id="747525.W4K4Y1"/>
    <dbReference type="GeneID" id="20677076"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_46047"/>
    <dbReference type="eggNOG" id="KOG2712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104273_1_3_1"/>
    <dbReference type="InParanoid" id="W4K4Y1"/>
    <dbReference type="OrthoDB" id="2505440at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.10">
        <property type="entry name" value="Transcriptional Coactivator Pc4, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003173">
        <property type="entry name" value="PC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009044">
        <property type="entry name" value="ssDNA-bd_transcriptional_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045125">
        <property type="entry name" value="Sub1/Tcp4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13215">
        <property type="entry name" value="RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02229">
        <property type="entry name" value="PC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54447">
        <property type="entry name" value="ssDNA-binding transcriptional regulator domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcriptional coactivator p15 (PC4) C-terminal" evidence="7">
        <location>
            <begin position="10"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW80425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="72" mass="8185" checksum="D691E3CE436077F1" modified="2014-03-19" version="1" fragment="single">KNYEGDQYIELAKKRRVTVRSFKGTTYVDIREFYGDAGDEKPGKKGISLSVEQWQTLVQSASIVDAMVKRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4K526</accession>
    <name>W4K526_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_434570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
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                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
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                <person name="Raffaello T."/>
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                <person name="Schmutz J."/>
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                <person name="Yakovlev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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</entry>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
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                <person name="Bouzid O."/>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
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                <person name="Hansson D."/>
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                <person name="Hietala A."/>
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                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Lucas S."/>
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    </evidence>
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    </evidence>
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</entry>
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                <person name="Lunden K."/>
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                <person name="Yakovlev I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">TC 32-1</strain>
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        </location>
    </feature>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
    <sequence length="240" mass="26009" checksum="A088BDF9F083977B" modified="2014-03-19" version="1">MSIAAASALYRYNEVVYARPADPFMHSDDENTIVLAECNGSLNNQRGRRGLGGGAIAGIVIGILALLSLIILVLFCRRRRAMRASSAARGDIPPPVPSKPQTRAAIDTVTPMHNVDSSTHYDQPLLLHHQRDLSSHPSSHPLSHPSLLTSHSSVTSSGLPSRNLSFSQPSTSAREIRADREMATTAPSSYSNTPAQFSTRRSSELHSEMVGYQKVLQDERRKGTSAAVDPPPSYEAIDVE</sequence>
</entry>
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    <accession>W4K5N0</accession>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547788.1">
        <property type="nucleotide sequence ID" value="XM_009549493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5N0"/>
    <dbReference type="STRING" id="747525.W4K5N0"/>
    <dbReference type="GeneID" id="20668244"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_169864"/>
    <dbReference type="HOGENOM" id="CLU_1855524_0_0_1"/>
    <dbReference type="InParanoid" id="W4K5N0"/>
    <dbReference type="OrthoDB" id="19224at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008383">
        <property type="entry name" value="API5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05918">
        <property type="entry name" value="API5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="138" mass="15738" checksum="F217CF8311C1B5B3" modified="2014-03-19" version="1">MVLVRLNGEVIVIFPVATFTLPKTTEHPPDDMDQHTTEQEREIRELIRRAEQTPVKTSPQRKEALQRLIELTRSPHSGLKTLAASNIAKFFKPFVDLDEDAINAIYDLCEDQDPQVAAVLCSEENHTDALYEGPNRWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5Z5</accession>
    <name>W4K5Z5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_33603</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546900.1">
        <property type="nucleotide sequence ID" value="XM_009548605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5Z5"/>
    <dbReference type="FunCoup" id="W4K5Z5">
        <property type="interactions" value="430"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K5Z5"/>
    <dbReference type="GeneID" id="20671762"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_33603"/>
    <dbReference type="eggNOG" id="KOG1278">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010714_4_1_1"/>
    <dbReference type="InParanoid" id="W4K5Z5"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF111">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007366265" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="25"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="523"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="563"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="594"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW80765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="633" mass="70342" checksum="DD73F39F3B8AF39C" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4K608</accession>
    <name>W4K608_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_117872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545916.1">
        <property type="nucleotide sequence ID" value="XM_009547621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K608"/>
    <dbReference type="GeneID" id="20666567"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_117872"/>
    <dbReference type="eggNOG" id="KOG0929">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_669136_0_0_1"/>
    <dbReference type="InParanoid" id="W4K608"/>
    <dbReference type="OrthoDB" id="18431at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF375">
        <property type="entry name" value="LD29171P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="1">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="411" mass="45100" checksum="F4EB7D69607DABBE" modified="2014-03-19" version="1">MCVPRAAHPRARLTRHGPVPVADTAYVISYSVILLNTDAHNPQVKKRMTRADFVKNNRGINEGADLPEELLSAIFDDIVNNGIRIKDEVDSSLVASLAPGAGLASALATVGQDLQREAYMLQSNGMAHKTEALFRTMMQSQCKGSRSGGQFFSVSHFLHVWPMFEVAWIPFLAGISGPLQETDNLDVVELCLDGFRNAVRIVCFFDLELERNAFVTTLAKFTFLNNLGDMKTKNMEAAQMLLDVTVMKGNNLKGSWREVLSRTRKLPNEELANESRSTHITVAADMTPAPVLVPLGYIMRDFTHSYLAAFQVSTQSIGLARSHGALYVVSDTTAQATRYFSRRLSLSLQEPFALQLSMPSVSQECLNALASRVKSSLKLLRTLKVQQAAAQSTISMLKSKVSSLGSLAQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4K620</accession>
    <name>W4K620_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_146275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547244.1">
        <property type="nucleotide sequence ID" value="XM_009548949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K620"/>
    <dbReference type="STRING" id="747525.W4K620"/>
    <dbReference type="GeneID" id="20667130"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_146275"/>
    <dbReference type="eggNOG" id="ENOG502QQW3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045794_0_0_1"/>
    <dbReference type="InParanoid" id="W4K620"/>
    <dbReference type="OrthoDB" id="506498at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000554">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43832">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43832:SF1">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="366" mass="42128" checksum="0D42B493181368B8" modified="2014-03-19" version="1">MIPDSVLTVGYNLLDKGLVPDFILRTAIRALCRQRLQEINHGSFETNHAAKMQWVENSRARETIAELTEKANEQHYEVSTDFILSCLGPFAKYSSCLYPTGKETLEEAEVLMMEMYCEKAKLRNGQYILDLGCGWGSLSLYLAQKYPRSQIMGLSNSSTQKLYIDAQAKKRGLNNVKTITADVNTIDFVDCDQFDRILSIEMFEHMKNYDKLLRKVSTWLKPSQHTGEGDDSNPSLLFVHIFCHKTMPYDFVEDDGWMAQTFFSGGTMPSHDLFLYYQSHLTLLSSSYISGIHYSRTLEHWLQRQDANAKHGLKELEMDAEKKGKKGEGAKAFYRFRVFYMACSELFAYNDGQEWGIGHYVFKRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4K651</accession>
    <name>W4K651_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Letm1 RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_385119</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547279.1">
        <property type="nucleotide sequence ID" value="XM_009548984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K651"/>
    <dbReference type="STRING" id="747525.W4K651"/>
    <dbReference type="GeneID" id="20672232"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_385119"/>
    <dbReference type="eggNOG" id="KOG1043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037786_0_0_1"/>
    <dbReference type="InParanoid" id="W4K651"/>
    <dbReference type="OrthoDB" id="73691at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="10">
        <location>
            <begin position="238"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="63"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW80546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="413" mass="45466" checksum="50E193727F2F1380" modified="2014-03-19" version="1">MIRSIGRNGAVERSLATQRRGSLFVHRQFRGHVVGYDVSLTTGIYSPGALTHPHFARLLSSSTQPPIVQKSPPATPSQPASLLPTSRKPKVELRPGPIKPAAKSSTRSDLNTPSVSSKLPTSSTQQSTTSSTPAPSTSSSILETTRQDLIHAHTHGIIPPPPPDAGRVQRMWHQLKEIFKFYVRGMKMVNTHRVQANEMRQRVKSGGPPLSRWESRFVATSQTDLLKLVPFVLIVLIAEEVIPLIVLYVPSMLPSTCIMPSQRERIENKRRDKQRVFVETMQDELAMISKVSPIHVALSSVTGSTPLLALCGVFSLSTMGPPFMRRRRLQRHLRAIAADDALLKQEGMGDRLTHPELLEALEQRGIVTAGAKLPALKSSLRWWLENVDKNDEGDSIGRRIALAARSAGVSSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6D0</accession>
    <name>W4K6D0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_104677</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545965.1">
        <property type="nucleotide sequence ID" value="XM_009547670.1"/>
    </dbReference>
    <dbReference type="GeneID" id="20666022"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_104677"/>
    <dbReference type="eggNOG" id="ENOG502S35T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_232762_0_0_1"/>
    <dbReference type="InParanoid" id="W4K6D0"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF65">
        <property type="entry name" value="PAXILLIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1819"/>
            <end position="1841"/>
        </location>
    </feature>
    <feature type="domain" description="CHAT" evidence="3">
        <location>
            <begin position="1250"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1669"/>
            <end position="1739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1878"/>
            <end position="1909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1923"/>
            <end position="2075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1925"/>
            <end position="1941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1981"/>
            <end position="1994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2048"/>
            <end position="2057"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW81294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="2075" mass="223596" checksum="7225DCB055C9CA2D" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6D6</accession>
    <name>W4K6D6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13 14">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="3 13 14">4.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HETIRDRAFT_440521</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>(R)-5-diphosphomevalonate + ATP = isopentenyl diphosphate + ADP + phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:23732"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 14">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="3 13 14"/>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547604.1">
        <property type="nucleotide sequence ID" value="XM_009549309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6D6"/>
    <dbReference type="FunCoup" id="W4K6D6">
        <property type="interactions" value="321"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K6D6"/>
    <dbReference type="GeneID" id="20675273"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_440521"/>
    <dbReference type="eggNOG" id="KOG2833">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040369_4_2_1"/>
    <dbReference type="InParanoid" id="W4K6D6"/>
    <dbReference type="OrthoDB" id="10253702at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000018">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000005">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977:SF3">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 13 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8 14" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="16">
        <location>
            <begin position="10"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Mvd1 C-terminal" evidence="15">
        <location>
            <begin position="194"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR015950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETW80910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="403" mass="43498" checksum="C20D63C8C226011F" modified="2014-03-19" version="1">MTVYQATVSAPVNIACIKYWGKRDTKLILPTNSSLSVTLDQDHLRSTTTSRADPSFDKDRLWLNGNEEEIKDGGRLATCITELKRLRRELEKDPKQPKLSTFPVHICSRNNFPTAAGLASSASGFAALVSSLAALYELPASPSELSLIARQGSGSACRSLFGGFVAWEQGTSPDGLDSFAVEVAPREHWPDIHALICVVSDDKKDTSSTSGMQRTVATSPLLQHRIAHVVPARMAAISEAIRARDFDAFARITMQDSNQFHAVALDTDPPIFYMNDVSRAIIALVTEYNRVAVAQGGKLKAAYTYDAGPNAVIYAPKENIKEIVELIVRYFPQAEPFKDSFGLFGVAGVGEGKVVDGFNAAVAKKHAVGAVKGLIHTRVGDGPRKLGQEEALLGAEGLPKFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7S2</accession>
    <name>W4K7S2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rho termination factor N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_417859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546393.1">
        <property type="nucleotide sequence ID" value="XM_009548098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7S2"/>
    <dbReference type="GeneID" id="20673426"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_417859"/>
    <dbReference type="eggNOG" id="ENOG502S7TZ">
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    </dbReference>
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            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="589" mass="65380" checksum="5BDCA870362043D7" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7Z8</accession>
    <name>W4K7Z8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_451593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009548209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7Z8"/>
    <dbReference type="GeneID" id="20676171"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_451593"/>
    <dbReference type="HOGENOM" id="CLU_2399941_0_0_1"/>
    <dbReference type="InParanoid" id="W4K7Z8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="109" mass="11700" checksum="0581C98354CF2F60" modified="2014-03-19" version="1">METAVGGTGVDDGDTTVNYDGDGDVSTVLPDELCTGACDGGRSGADIAAWNDIYTLRTGWTEHCDLRPWGTNTLTFDAPDGTFSSLHWAIASPVTPRAAPSYHRTRFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9N7</accession>
    <name>W4K9N7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <lineage>
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            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546641.1">
        <property type="nucleotide sequence ID" value="XM_009548346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9N7"/>
    <dbReference type="GeneID" id="20674189"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_427239"/>
    <dbReference type="HOGENOM" id="CLU_050560_0_0_1"/>
    <dbReference type="InParanoid" id="W4K9N7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="401" mass="43943" checksum="241BED4278CBE438" modified="2014-03-19" version="1">MLLHNDNTASSPSRNSSPNIILMVANLDIKHVNRGTSPTPPESNTTITILTQSLNNFSDNDAKDYAKFKEREWTHTNKQPSRRSSQDAPWDEGTYDKNNGGPSGPTTEVPPSIGVTTTPGTGSPLGLHARGGGQQPGNGATDPVPVLPGITKLTVPVSGQVPSTMGRITHRPNPHFGELEQYMDTLLQQNIISANNQEMKTTIASLQIRTLALQTNPNTASGYEDNDGRPRALLIYLDEFTQYVNQELLLALLFLGELGDIQAVRTNPFCVITWNVPPCIGKRPAAIPNPRGVPHSCGTPSSVTTRGYEIFPYPMEIPTRRNRPSIEEPKEEETKEPRQPSNAECILAGVFNTSLECLLLIIDFVQTRDRIAKVAAELAILIQRLEEIASRLNPSSMPRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9T2</accession>
    <name>W4K9T2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TIGR04076 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_318428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546412.1">
        <property type="nucleotide sequence ID" value="XM_009548117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9T2"/>
    <dbReference type="GeneID" id="20670512"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_318428"/>
    <dbReference type="eggNOG" id="ENOG502S1E4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146836_0_0_1"/>
    <dbReference type="InParanoid" id="W4K9T2"/>
    <dbReference type="OrthoDB" id="2838513at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023811">
        <property type="entry name" value="CHP04076"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04076">
        <property type="entry name" value="TIGR04076 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="12958" checksum="420C9E2C05A779AC" modified="2014-03-19" version="1">MDATASADTFELFDLRVEAICPPGEKILCGAKPGDHFTLEGEMLRLPPGQGFSIFSLGAVLPLLAAKQRLSSSNDWMETDEEVACPDPNCRSRLRIVRTGRRVFKHGETTVVPLEEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4KA89</accession>
    <name>W4KA89_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">coproporphyrinogen oxidase</fullName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_409772</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546800.1">
        <property type="nucleotide sequence ID" value="XM_009548505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KA89"/>
    <dbReference type="FunCoup" id="W4KA89">
        <property type="interactions" value="322"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KA89"/>
    <dbReference type="GeneID" id="20672800"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_409772"/>
    <dbReference type="eggNOG" id="KOG1518">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026169_0_1_1"/>
    <dbReference type="InParanoid" id="W4KA89"/>
    <dbReference type="OrthoDB" id="15318at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018375">
        <property type="entry name" value="Coprogen_oxidase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003727">
        <property type="entry name" value="PRK05330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755:SF0">
        <property type="entry name" value="OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000166">
        <property type="entry name" value="Coproporphyri_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01021">
        <property type="entry name" value="COPROGEN_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW82265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="379" mass="41830" checksum="630714546B517F2C" modified="2014-03-19" version="1">MSTSPPPMRDRVAAYITTLQDKIVSALEHLDPAAPPFLRDAWQRPEGGHGISCVFQVPYPTDPAAPPPTTLLEKAGVNVSVIHGSLPPAAIKQMRADHASVPYDPDSTASLPFFAAGISLIIHPRSAHAPTVHANYRYFEITDKPTTANTSTDADADAPPKVLAWWFGGGSDLTPSYLYDADAAHFHATLKQACDAHGAALYPAFKRWCDEYFYLPHRGETRGVGGLFFDDLTDAPHKRLPDPTDPAPPAKPDTRAQRPFSQEAIFAFVRSAGDALIPSYLPLLERRARAPTSAAERRWQLLRRGRYVEFNLVYDRGTKFGLMTPGARIESILVSLPEVARWEYRTEVGELEGSEEARLMGVLKKPKEWAYARADAYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAF0</accession>
    <name>W4KAF0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_61170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545857.1">
        <property type="nucleotide sequence ID" value="XM_009547562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAF0"/>
    <dbReference type="STRING" id="747525.W4KAF0"/>
    <dbReference type="GeneID" id="20678538"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_61170"/>
    <dbReference type="eggNOG" id="ENOG502S1RM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_12_3_1"/>
    <dbReference type="InParanoid" id="W4KAF0"/>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF3">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="29"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="322" mass="34326" checksum="9EB4B16CD3FBAD92" modified="2014-03-19" version="1">MKVLVIGSVKFSCTCSSWWLNTFPHLSSATGMIGRPIAQALSRAGHIVYGQTRSASKAKQLSAGEIFPVIGDPACPENWIDIVQNIDIVIDAVGGENSATIAPSLHKAVSDAAARRPPGTPPLTYIYTSGMWVHGDDRATIVTDGSPIVSPLRLVAWRPAVEDVILRSSGAVRGIVIRPGLLYGQGGSLFAALFASAAKGNIVWPGAPGGRYATVHADDLADLYVRVVGHAAALGGLVFDATREHSESVDLLLLRMAEVSGAERYEYKKPTNLLEEALSATIIARPTLARTMLGWESHKPDLVDGLEMYYAAWKARQGEVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBA9</accession>
    <name>W4KBA9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_384745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546858.1">
        <property type="nucleotide sequence ID" value="XM_009548563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBA9"/>
    <dbReference type="STRING" id="747525.W4KBA9"/>
    <dbReference type="GeneID" id="20672212"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_384745"/>
    <dbReference type="eggNOG" id="ENOG502SUTR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_407712_0_0_1"/>
    <dbReference type="InParanoid" id="W4KBA9"/>
    <dbReference type="OrthoDB" id="107110at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33266">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33266:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="836" mass="94318" checksum="AD915E44BE7BF402" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBH5</accession>
    <name>W4KBH5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4100 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_225522</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
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                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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                <person name="Martin F."/>
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            <strain evidence="4 5">TC 32-1</strain>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13352"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
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    <sequence length="1117" mass="124916" checksum="C0FB20372727571F" modified="2014-03-19" version="1" fragment="single"> </sequence>
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                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">TC 32-1</strain>
        </source>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW82795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
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</entry>
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            <taxon>Heterobasidion annosum species complex</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Gonthier P."/>
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                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
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                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
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    </reference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_425366"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="281"/>
        </location>
    </feature>
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        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="322" mass="37215" checksum="9C7419A341C839FA" modified="2014-03-19" version="1">MEPQEALTSTHDYLLALSKRPERVFGSTKDIDISGRDTGWQDHKELSDMDVILLRDTWNRLGSLIPYHSGGFYIPGSLSPEARYTAYSVLQSKEFGIRHTDMQMSRFVVRWARPGDEQSDLTLALTGWEHAHRAPLWSCARMPPWLIPHIHPYELITWEGQRNVRHFIFQSIYHSDFIPRDAAWEWIVAYVYGHTERWFEGLLGSHWAFRDSAEVLLVRLREHWLRERPDVPFPLEVGGPYLSGVPVRPNVIAEQNRGRTQRRPGRESGDKPKLPLPLPVPPETNMTLAQMQATLMKLRGDVVYERVPWPEKGIGPDPNDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDE6</accession>
    <name>W4KDE6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_472206</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543612.1">
        <property type="nucleotide sequence ID" value="XM_009545317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDE6"/>
    <dbReference type="FunCoup" id="W4KDE6">
        <property type="interactions" value="335"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KDE6"/>
    <dbReference type="GeneID" id="20677444"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_472206"/>
    <dbReference type="eggNOG" id="KOG3452">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140672_0_0_1"/>
    <dbReference type="InParanoid" id="W4KDE6"/>
    <dbReference type="OrthoDB" id="9616667at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1760:FF:000001">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01190">
        <property type="entry name" value="RIBOSOMAL_L36E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW83877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="101" mass="11745" checksum="C333BE862240EF8E" modified="2014-03-19" version="1">MVRNDTRRGLAHGHPTTAIPKTVRPSQRKGIQSTRTKFVRSVVREVVGFSPYERRVMELLRNSKDKKARKLTKKRLGTLLRSKRKLEELGNIIQESRRTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDG6</accession>
    <name>W4KDG6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="3">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_146597</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="3"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543522.1">
        <property type="nucleotide sequence ID" value="XM_009545227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDG6"/>
    <dbReference type="FunCoup" id="W4KDG6">
        <property type="interactions" value="366"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KDG6"/>
    <dbReference type="GeneID" id="20667153"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_146597"/>
    <dbReference type="eggNOG" id="KOG2112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049413_3_8_1"/>
    <dbReference type="InParanoid" id="W4KDG6"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000010">
        <property type="entry name" value="Acyl-protein thioesterase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="13">
        <location>
            <begin position="9"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW83774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="243" mass="26159" checksum="0C73EA41046CB80B" modified="2014-03-19" version="1">MASPPLLDALVVQPAAKHTATVIFVHGLGDSGHGWSPVANSFKTDPGLRHVKWVLPHSPSIKVTANMNLEMPSWFDIIEFGFMSEEDETGMLRTVRSINQLITAEIDAGIPAERILLGGFSQGAAMSILIGLTNERRLAGVVALSGWLPLRHKFKSMATEHARAMPIFWGHGTHDPLVKYQFGVDSVEFLKTDVGIAATTLAGADAAALRGIAFNSYSGLGHSANDKELADLKEWLKKVVAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDM0</accession>
    <name>W4KDM0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_235489</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543815.1">
        <property type="nucleotide sequence ID" value="XM_009545520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGA8"/>
    <dbReference type="FunCoup" id="W4KGA8">
        <property type="interactions" value="254"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KGA8"/>
    <dbReference type="GeneID" id="20667376"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_150945"/>
    <dbReference type="eggNOG" id="ENOG502RYJ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031468_2_1_1"/>
    <dbReference type="InParanoid" id="W4KGA8"/>
    <dbReference type="OrthoDB" id="3609at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF43">
        <property type="entry name" value="KETOPANTOATE REDUCTASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="4">
        <location>
            <begin position="14"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="5">
        <location>
            <begin position="207"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW84106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="38005" checksum="86591E25A016E749" modified="2014-03-19" version="1">MCNGLPQPVDMLQICVVGLGAIGTYYALALEKSGRAQVTAVCRSNLGTLIENGVDVVSDGLGRVAAWKPHRAVPTPEEAADRRYDFVICAFKALPDVNPTPKLIAPLLHSTDCFVLIQNGIGIHADLQAARPDAAIISSCAWIDATTVGGGRSVVQSGPDKLTSGLHPGLVASSEDGQTAEDEGVQSLRLFHELLVAGGAGSEVTDDINAARWQKILWNATFSTLCTVSRSPVADLLCSQLLPVTLPTVKGIMEEVVSVARSTGVTASKLPENKVDQVIADCLEQYSDERRTSPSRFKPSMLVDLEAGRPMEVEPIVGSVVKIARKHAVATPRLDMIYAQLMILQRAVLRARHVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGM4</accession>
    <name>W4KGM4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_470064</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW84997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541894.1">
        <property type="nucleotide sequence ID" value="XM_009543599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGM4"/>
    <dbReference type="FunCoup" id="W4KGM4">
        <property type="interactions" value="621"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KGM4"/>
    <dbReference type="GeneID" id="20677325"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_470064"/>
    <dbReference type="eggNOG" id="KOG2604">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011639_1_0_1"/>
    <dbReference type="InParanoid" id="W4KGM4"/>
    <dbReference type="OrthoDB" id="296793at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048685">
        <property type="entry name" value="COG3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048320">
        <property type="entry name" value="COG3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007265">
        <property type="entry name" value="COG_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302:SF8">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20671">
        <property type="entry name" value="COG3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04136">
        <property type="entry name" value="COG3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 N-terminal" evidence="10">
        <location>
            <begin position="154"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 C-terminal" evidence="11">
        <location>
            <begin position="319"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="84"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW84997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="858" mass="95313" checksum="5FD8961A9BFB2BBA" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHU4</accession>
    <name>W4KHU4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_243369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542291.1">
        <property type="nucleotide sequence ID" value="XM_009543996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHU4"/>
    <dbReference type="GeneID" id="20668982"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_243369"/>
    <dbReference type="eggNOG" id="ENOG502SEVI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123408_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHU4"/>
    <dbReference type="OrthoDB" id="21330at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="146" mass="15846" checksum="2289A7927400B1F7" modified="2014-03-19" version="1" fragment="single">ASPLPAAVSEPIRILHAQLMQSPHLEPSALLVRDPIPTPPGPPLPDAVPKGKRKRGGTHAGHGVAFQGGIWSWIVLAQVKEGTEKRGAIESVVRLVRKTLLTMDPPLPLPKNSRRTVSDGWAMVDAGDFAVHIVSRDAYQKFFTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHW6</accession>
    <name>W4KHW6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein CPL1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_309020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542299.1">
        <property type="nucleotide sequence ID" value="XM_009544004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHW6"/>
    <dbReference type="GeneID" id="20669635"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_309020"/>
    <dbReference type="HOGENOM" id="CLU_1949080_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHW6"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048661">
        <property type="entry name" value="CPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038955">
        <property type="entry name" value="PriA/CPL1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21671">
        <property type="entry name" value="CPL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein CPL1-like" evidence="1">
        <location>
            <begin position="66"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="129" mass="14107" checksum="47C60887B2A62342" modified="2014-03-19" version="1">MEYVPIQDFINPDSVSYASIHTDDISDQLCPSGLSVCPFVNQAESQPQGLAWSETWTLDNLVNHGFNCPNFDRDLENCGGCSVLDATFNCSDISNAVKTSCVTGRCIVGSCDEGYAISYMQDRCVIMND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4KI55</accession>
    <name>W4KI55_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sorbose reductase sou1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_311043</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542393.1">
        <property type="nucleotide sequence ID" value="XM_009544098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KI55"/>
    <dbReference type="STRING" id="747525.W4KI55"/>
    <dbReference type="GeneID" id="20669825"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_311043"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="InParanoid" id="W4KI55"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000245">
        <property type="entry name" value="Short chain dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="17"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW85543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="36123" checksum="13B49AEDF7EC8008" modified="2014-03-19" version="1">MLLSVRNALLRRTAALASATRTRAAAPPPLTRHFTTTRPASTAKTPPAAAPAAQSSSPPAPRGVALALAAQTDARIAPRARLRDEFTLAGRVALVSGANRGLGLEMALALAEAGARAVYCVDLPASPGAEWEAVAEYVKRMGAGEGKGEGTRMEYVCADVTDQARMWAVGRAIGEREGRMDVCVAAAGILREHTDCLEYPAEQFRKVFDVNANGVLFTAQAAGREMVRFGNAGSIILIASMSGSITNKDHAWVSYNSSKSAVLQMGRSMACELGAKGIRVNTLSPGHIYTSMTAAYLDKQPELFEKWSRSNPLGRLGRPDELRGVVAWLASDASTFCTGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIJ1</accession>
    <name>W4KIJ1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_457373</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TACO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542376.1">
        <property type="nucleotide sequence ID" value="XM_009544081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIJ1"/>
    <dbReference type="STRING" id="747525.W4KIJ1"/>
    <dbReference type="GeneID" id="20676823"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_457373"/>
    <dbReference type="eggNOG" id="KOG2972">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_507203_0_0_1"/>
    <dbReference type="InParanoid" id="W4KIJ1"/>
    <dbReference type="OrthoDB" id="2017544at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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        <location>
            <begin position="224"/>
            <end position="295"/>
        </location>
    </feature>
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        <location>
            <begin position="370"/>
            <end position="537"/>
        </location>
    </feature>
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        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
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        <location>
            <begin position="238"/>
            <end position="268"/>
        </location>
    </feature>
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        <location>
            <begin position="431"/>
            <end position="465"/>
        </location>
    </feature>
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        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
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            <end position="526"/>
        </location>
    </feature>
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        <location>
            <begin position="527"/>
            <end position="537"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW85524.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="537" mass="57830" checksum="F8693CEC80E4F736" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJ94</accession>
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        </submittedName>
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            <taxon>Russulales</taxon>
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            <taxon>Heterobasidion</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
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                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
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            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW85769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="57" mass="6191" checksum="F2C7E8EBA16F026E" modified="2014-03-19" version="1">MAFTGSDICKIIFAVLLPPIGVFLERGCGADLVINILLTILGYIPGIIHALYIILKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKN5</accession>
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        <recommendedName>
            <fullName evidence="4">Anaphase-promoting complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_456534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Kues U."/>
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                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_009542139.1"/>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_456534"/>
    <dbReference type="eggNOG" id="ENOG502S8RC">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="678" mass="73249" checksum="4BBA4024466C92B2" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKN8</accession>
    <name>W4KKN8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_449133</name>
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    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
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            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543025.1">
        <property type="nucleotide sequence ID" value="XM_009544730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKN8"/>
    <dbReference type="GeneID" id="20675916"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_449133"/>
    <dbReference type="HOGENOM" id="CLU_1787097_0_0_1"/>
    <dbReference type="InParanoid" id="W4KKN8"/>
    <dbReference type="OrthoDB" id="2637024at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="160" mass="18080" checksum="BA05DFD3ECF109DE" modified="2014-03-19" version="1">MSSVRPPYPSFTLVMSSNMSTMSNPADTSRLPAYRASHLGRFHPYPRAHPSYHENYMSFPSSAFVCDAQTTVDYRYGDPPIFQPQPRSSFALPAIIIEDCDIKIDSDSGDTDTAVDRRNRLNLKTFSHYVLAFAVAVQRKCRRTAVVKKMGDEPRLDLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KL57</accession>
    <name>W4KL57_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_423666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540456.1">
        <property type="nucleotide sequence ID" value="XM_009542161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KL57"/>
    <dbReference type="GeneID" id="20673931"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_423666"/>
    <dbReference type="HOGENOM" id="CLU_906308_0_0_1"/>
    <dbReference type="InParanoid" id="W4KL57"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="307" mass="33515" checksum="2AF828531DAA5970" modified="2014-03-19" version="1">MYLPRLPRTHTTSSAQPKRETCPKKPAKTGRRKCPVPLQALTKAFECLSGRLPKRRQAGRKQKRKSDEPSSEGAPKGKPPIPFARPTDGRSRGAVATDAGMSTIEVGTTILKEVADLALGVPYLQIIAAVLSQIVKVHGEVRMLSDKCSDLKGYVNELRRLVDGIKDSLGGTEHVPKDLAQALNFLTRLHRAYTGPIQPGSGRPIHANASFSSAHSDLPASALDDTVHVYTECTAKMTVRKILKRGLLLGEIQECQNRVQYALALFNTKLGVIQFSDAQKAYEVLEDTRGMVKCIQQTVGKQLVSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLH9</accession>
    <name>W4KLH9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_240951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540564.1">
        <property type="nucleotide sequence ID" value="XM_009542269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLH9"/>
    <dbReference type="GeneID" id="20668875"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_240951"/>
    <dbReference type="eggNOG" id="ENOG502SPUM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112288_0_0_1"/>
    <dbReference type="InParanoid" id="W4KLH9"/>
    <dbReference type="OrthoDB" id="3133596at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="22433" checksum="7FB7733674821138" modified="2014-03-19" version="1" fragment="single">AISNIKHCLVTNELASEARIEPCYLLNQRLWDNKEMLTRLEWHWGMKYSSLELDVEANRIYLRQDLLESFDSNRWLLLPPPEMRKATTAHRDGSCFHLSSKIHLMILQLYEGAETFEYRLLPLRHGIESIDRFDQPNSIRTFSPAAEQSPTRYSNPFDTLPTLVSRAKPHFVICDSAAKLFHETTSGPSGLARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLJ3</accession>
    <name>W4KLJ3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_166214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540695.1">
        <property type="nucleotide sequence ID" value="XM_009542400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLJ3"/>
    <dbReference type="GeneID" id="20668042"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_166214"/>
    <dbReference type="HOGENOM" id="CLU_2979348_0_0_1"/>
    <dbReference type="InParanoid" id="W4KLJ3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="58" mass="6841" checksum="3FC3B233431BA8C4" modified="2014-03-19" version="1">MTTAEDLKRTLMTTLLMPAQQMEDLTAQRESNLRHSIHYPHSFTSPLFLLDLLRAWIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLK4</accession>
    <name>W4KLK4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_32194</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541738.1">
        <property type="nucleotide sequence ID" value="XM_009543443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLK4"/>
    <dbReference type="FunCoup" id="W4KLK4">
        <property type="interactions" value="593"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KLK4"/>
    <dbReference type="MEROPS" id="M41.018"/>
    <dbReference type="GeneID" id="20670798"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_32194"/>
    <dbReference type="eggNOG" id="KOG0734">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_16_2_1"/>
    <dbReference type="InParanoid" id="W4KLK4"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000002">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002568">
        <property type="entry name" value="Cell division protein (FtsH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF97">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="9"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="422"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="438"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW85926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="449" mass="48858" checksum="1EAAA4CBE09C6A41" modified="2014-03-19" version="1">MFAALGGKLPKGILLTGSPGTGKTMLARAVAGEAGVPFLFASGSEFDEMFVGVGAKRVRELFAAARKKQPAIIFIDELDAIGGKRNARDQQYMKQTLNQLLVEMDGFLQDENVIVIAATNFPESLDEALVRPGRFDRHIAVPLPDIRGRSQILKHHMTDVVIGNDVDPMILARGTPGFSGADLQNMVNQAAIQASKEGSKEVNAKHLEWAKDRIVMGAERKSQYIDEHVKKLTAYHEGGHALAALYTPGSMPLHKVTCVPRGHALGVTSQLPENDRLSVTFKEFLADIDVSLGGRAAEELIFGRENVTSGASSDLKHATAVATRMVKNFGYSDKIGPVYLNERDEIISPSKREDIESEVRGLLRAGQARVFELLKSKQQELHRLANALIEHETLDMEEVKKVIRGEPIRNIKEVITEDLSRMAAGAGAPAPASPSAHAHSHSHSHSHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLL0</accession>
    <name>W4KLL0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_447417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540732.1">
        <property type="nucleotide sequence ID" value="XM_009542437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLL0"/>
    <dbReference type="GeneID" id="20675776"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_447417"/>
    <dbReference type="HOGENOM" id="CLU_1482160_0_0_1"/>
    <dbReference type="InParanoid" id="W4KLL0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="182" mass="20441" checksum="97E947D412F10A7A" modified="2014-03-19" version="1">MNALWALESTYLRPSSSLEDSPRQTPQLRTEGPRNLIHSPLRIVPDRSQCGGRSRACLDVKECQAGQAGDLMNALWALESTYLRASSSLEDYLANYDEKLDRTARPYHSVFHETERLRPSSVHASRLAVGTPPEMNELKNRAHTTSARPCESPHREAPLTHPHSLPHSTRASRLQESHSNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4KM41</accession>
    <name>W4KM41_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_58532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540370.1">
        <property type="nucleotide sequence ID" value="XM_009542075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KM41"/>
    <dbReference type="GeneID" id="20678436"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_58532"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006937_6_1_1"/>
    <dbReference type="InParanoid" id="W4KM41"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF7">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="65218" checksum="ABA7F9854E0D2B50" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KN45</accession>
    <name>W4KN45_HETIT</name>
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        <recommendedName>
            <fullName evidence="2">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_413567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541164.1">
        <property type="nucleotide sequence ID" value="XM_009542869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KN45"/>
    <dbReference type="STRING" id="747525.W4KN45"/>
    <dbReference type="GeneID" id="20673116"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_413567"/>
    <dbReference type="eggNOG" id="ENOG502S78R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118210_0_0_1"/>
    <dbReference type="InParanoid" id="W4KN45"/>
    <dbReference type="OrthoDB" id="302705at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF13">
        <property type="entry name" value="AT30094P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="2">
        <location>
            <begin position="37"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW87237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="176" mass="19488" checksum="8773DF56D3F6A8A7" modified="2014-03-19" version="1">MSSRIWRSYALRFLDHTNFTVTSLTAGVVLYSCSAGVAYFSLGAVACSLTVKVLKRVFRQPRPLHPKNKRTYGMPSTHSATITYFGTYIPLACAYLPIHPSFPSSAMSRTVPPLIVIPWAALIAISRIWLGHHTWPQVLCGCAYGFAFAFLWFAIWTHGGSQYGDIAEAHVQSLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNL7</accession>
    <name>W4KNL7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_231015</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540942.1">
        <property type="nucleotide sequence ID" value="XM_009542647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNL7"/>
    <dbReference type="GeneID" id="20668712"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_231015"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_924381_0_0_1"/>
    <dbReference type="InParanoid" id="W4KNL7"/>
    <dbReference type="OrthoDB" id="3269759at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481:SF22">
        <property type="entry name" value="RETROTRANSPOSON GAG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW86985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="291" mass="31670" checksum="EEEE2DCA15A14B95" modified="2014-03-19" version="1" fragment="single">MGPAVQAMSLANSITVTTVPKLSEDLSNWPIYKDRVQTAIESKTGLSRHLAGTARQPREPELPAEDAKDDVLEKYDKAIEKVDEYNQREAAIKQQIYSTIPDSILNRIKGETTAKEVWTALCDLAEKRGKMVEIDIRRRIHDSRCQEGGDVRAHLDTLIALQNELIGMDAALGDDDFVAVILSSLPKSYESIISVMTAASSLSSKPLTPSGIIQHLTQEHDRRSIQGRLEKKAPSDETALYSHGGGKQGKGGRGKGKKGNQSSSGKKCYNCGLTNHIAADCFRPGGGKEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNQ0</accession>
    <name>W4KNQ0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_413631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541230.1">
        <property type="nucleotide sequence ID" value="XM_009542935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNQ0"/>
    <dbReference type="GeneID" id="20673120"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_413631"/>
    <dbReference type="eggNOG" id="ENOG502SMIW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016384_0_0_1"/>
    <dbReference type="InParanoid" id="W4KNQ0"/>
    <dbReference type="OrthoDB" id="2564696at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
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        <location>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
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                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Lucas S."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
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    </evidence>
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        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="3"/>
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        </location>
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        </location>
    </feature>
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    </evidence>
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<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
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            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553231.1">
        <property type="nucleotide sequence ID" value="XM_009554936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JMN6"/>
    <dbReference type="STRING" id="747525.W4JMN6"/>
    <dbReference type="GeneID" id="20678034"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_482531"/>
    <dbReference type="eggNOG" id="KOG1823">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_490102_0_0_1"/>
    <dbReference type="InParanoid" id="W4JMN6"/>
    <dbReference type="OrthoDB" id="2743737at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW74744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="51260" checksum="CE9A9230B1BB6E03" modified="2014-03-19" version="1">MQKLAHDLRSVLAPSYFDILQKLLHLLSRSLSPEALTALLATLSALFKYILIPSANEEMLEKTWKITQPTLRGCNPEAGRAVAEVWGSLLRRLKTDFRGKAVKLMMLDSDGVEDLCAWAVVYACKSVSQTLHTASSSIISPLIASFLQAEDRTKTYTCIRRVLTALIHHCKNADEFCAIADVLLRCFTEAVESTDSERLGGIMDVVSIACSIRQGSRLSAKHLSAIVLASLSIPISVHSSHLSFATSVLTAGDMSLWIGPGRKLVELSWLDALFGIKLCGALSDLGWKGWKLVELPHVTKQTLQLLEGRSLDILELLATLHQAKRLDDADEVWIRQVQTWATSRFKTERSLRVEELQHILTMSGIMPSISKLLIKLINTTLDIPDDVQKDYRASPANKTWVLASCMKALAEQDTKTWVGIDLHAWTQAVISRWYWSEHVLGALVSLIEARYDELSSLISLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMY0</accession>
    <name>W4JMY0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_461496</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553354.1">
        <property type="nucleotide sequence ID" value="XM_009555059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JMY0"/>
    <dbReference type="FunCoup" id="W4JMY0">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JMY0"/>
    <dbReference type="GeneID" id="20677174"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_461496"/>
    <dbReference type="eggNOG" id="KOG1638">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065395_0_1_1"/>
    <dbReference type="InParanoid" id="W4JMY0"/>
    <dbReference type="OrthoDB" id="5788137at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF43">
        <property type="entry name" value="STEROID 5-ALPHA-REDUCTASE DET2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="130"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="271"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW74888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="323" mass="35800" checksum="C3FC4CDF7142623A" modified="2014-03-19" version="1">MAHNPSVLAQVWLLLKQVDYESVYTVSKRWFLFVPTVIFPATFFYDAPFGRFSTPGSLLALDGIRSWIFMELISPMSFLLTAFLHPFSRTPLSVLSPQALLTALYLTHYVNRAVLSPLRTPSRAPSHPAVVVSAIFFNGPNGFLLAAYLTSTAAATFLANAYTHPRFWLGLILWAVGFAGNIIHDEILLNIRRKAKAKGKAKEKSQGEHYSIPHGLLYKYISYPNYFCEWVEWLGFALAASPLPDVGLLPAASTVLTALSAGSVSAVGGLFTLFADSVAPPWAFLAAEVLLMLPRAVRGHRWYLQRFGEAYPSGRRIVVPFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMZ5</accession>
    <name>W4JMZ5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_412753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553309.1">
        <property type="nucleotide sequence ID" value="XM_009555014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JMZ5"/>
    <dbReference type="GeneID" id="20673065"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_412753"/>
    <dbReference type="eggNOG" id="ENOG502S7GG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085447_0_0_1"/>
    <dbReference type="InParanoid" id="W4JMZ5"/>
    <dbReference type="OrthoDB" id="5386199at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009724">
        <property type="entry name" value="TMEM70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045325">
        <property type="entry name" value="TMEM70/TMEM186/TMEM223"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13281">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13281:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06979">
        <property type="entry name" value="TMEM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW74834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="252" mass="27016" checksum="0FC28E8ECD859BCE" modified="2014-03-19" version="1">MKHCTVLPIPSIAHHLLRNSNHAPYRQHLTTLRALSTTAASPLSTTTLSSKPTISPPTTDAPESLALIYQGPLAPTFKRLKIFSLSSLTLSFLLSPFIFIIESGLPLSARAALAGIAIGTSGVSTALVSWCGQPYVTAMHRGAADGVLELTTLTLALHSRVTRVYDPAFLEDATRPFARWSLASAVQLPSGEARMPAVGSEETVSETTDAKGNVLGRWVVTWAENGEGNCRAVGQVVRHFNVHEELLDTPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JN00</accession>
    <name>W4JN00_HETIT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_482748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553398.1">
        <property type="nucleotide sequence ID" value="XM_009555103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JN00"/>
    <dbReference type="GeneID" id="20678052"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_482748"/>
    <dbReference type="HOGENOM" id="CLU_342569_0_0_1"/>
    <dbReference type="InParanoid" id="W4JN00"/>
    <dbReference type="OrthoDB" id="2756873at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="50"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW74937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="852" mass="92690" checksum="3E5571ECC926BB93" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4JN72</accession>
    <name>W4JN72_HETIT</name>
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        <recommendedName>
            <fullName evidence="3">XPG N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_482733</name>
    </gene>
    <organism evidence="4 5">
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        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asteroid family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925467">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009555092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JN72"/>
    <dbReference type="GeneID" id="20678050"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_482733"/>
    <dbReference type="eggNOG" id="ENOG502QQRA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_314230_0_0_1"/>
    <dbReference type="InParanoid" id="W4JN72"/>
    <dbReference type="OrthoDB" id="25987at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026832">
        <property type="entry name" value="Asteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665">
        <property type="entry name" value="ASTEROID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665:SF1">
        <property type="entry name" value="PROTEIN ASTEROID HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="774"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="777"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW74924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="815" mass="90557" checksum="1BE4D5D045ACC97B" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNA3</accession>
    <name>W4JNA3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_332018</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009555179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNA3"/>
    <dbReference type="GeneID" id="20671697"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_332018"/>
    <dbReference type="HOGENOM" id="CLU_163763_1_0_1"/>
    <dbReference type="InParanoid" id="W4JNA3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW75023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="52" mass="5615" checksum="8FA160CF4A86F13E" modified="2014-03-19" version="1" fragment="single">VKYGQTDPSAAECPLVGYGQSGEDCPYSVIVSILGTYLALFDIFSKLPKYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNR4</accession>
    <name>W4JNR4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4939 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_108566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553195.1">
        <property type="nucleotide sequence ID" value="XM_009554900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNR4"/>
    <dbReference type="GeneID" id="20666356"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_108566"/>
    <dbReference type="eggNOG" id="ENOG502S3G3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1094414_0_0_1"/>
    <dbReference type="InParanoid" id="W4JNR4"/>
    <dbReference type="OrthoDB" id="8955945at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW74705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="30484" checksum="62D34A994902A520" modified="2014-03-19" version="1">MAVYSNMIITNIKRPHKQDLGQEYPLGTRHINNQLRHNNHPIWREGDFWVYEDNNRFAPPNHDNCSYRNGRYYFTLEDGTEEKDIWNEIESQWELAPQYRELAPVIPEDSEQEETTSQSDSDSSPNQTLINTQNEPLAKMSGQASTSTDPPSMTVQPGRGKVKLPDNYTGNHIESQKFMLQCLLLFAAESDRYKTNQDKISLVLSCMRYGMAGAWAENFLLKSVGADPPTDLGTWRDFLMKFKLQFRETGKTDKARSILMTFSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNY7</accession>
    <name>W4JNY7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Importin subunit beta-1/Transportin-1-like TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_68096</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the importin beta family. Importin beta-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553083.1">
        <property type="nucleotide sequence ID" value="XM_009554788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNY7"/>
    <dbReference type="FunCoup" id="W4JNY7">
        <property type="interactions" value="988"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JNY7"/>
    <dbReference type="GeneID" id="20678845"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_68096"/>
    <dbReference type="eggNOG" id="KOG2023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008136_1_0_1"/>
    <dbReference type="InParanoid" id="W4JNY7"/>
    <dbReference type="OrthoDB" id="951172at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000028">
        <property type="entry name" value="Transportin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin subunit beta-1/Transportin-1-like TPR repeats" evidence="10">
        <location>
            <begin position="517"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="327"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW74770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="922" mass="102987" checksum="44A1ABCD745FE61A" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNZ2</accession>
    <name>W4JNZ2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_240776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552647.1">
        <property type="nucleotide sequence ID" value="XM_009554352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNZ2"/>
    <dbReference type="GeneID" id="20668871"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_240776"/>
    <dbReference type="HOGENOM" id="CLU_2503868_0_0_1"/>
    <dbReference type="InParanoid" id="W4JNZ2"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW75209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="86" mass="9127" checksum="2C96979E96AA3F3B" modified="2014-03-19" version="1" fragment="single">MLALEPGSLCDVCAVEYGPRNLPHSIACGHVLCHPCCTTIIEKTPRTRTPACPFCRDPFSAATIRLVRIDVPPPPPSSSTTSSAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPB1</accession>
    <name>W4JPB1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_423072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552793.1">
        <property type="nucleotide sequence ID" value="XM_009554498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPB1"/>
    <dbReference type="GeneID" id="20673866"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_423072"/>
    <dbReference type="HOGENOM" id="CLU_1806418_0_0_1"/>
    <dbReference type="InParanoid" id="W4JPB1"/>
    <dbReference type="OrthoDB" id="3256826at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW75368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="143" mass="16196" checksum="3E1A6DE159D85C22" modified="2014-03-19" version="1">MSLHNGILYLSGWLIIPSIPTIFKSLLSLTHDSLRHFGSNKYYTVNKSLPLKPLGPLYPLPISNAHGNSVAIKFIRPLPIDSGYNMIISMTYISSSNIHIIPTKSTLTVKEFVVLFFDHWYCENGLPFKIDQIETVFYTPPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPV6</accession>
    <name>W4JPV6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_430610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552567.1">
        <property type="nucleotide sequence ID" value="XM_009554272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPV6"/>
    <dbReference type="GeneID" id="20674465"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_430610"/>
    <dbReference type="HOGENOM" id="CLU_556738_0_0_1"/>
    <dbReference type="InParanoid" id="W4JPV6"/>
    <dbReference type="OrthoDB" id="2751369at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="332"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW75115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="490" mass="55521" checksum="32F27AEF37DEC1AD" modified="2014-03-19" version="1">MGSWDELCLLCGICPAGGPSALLHRNDLHDIACQLAAEIRVDTLTDDDILSIVTEALTSSFSDDDRMLGYRPKWLPDGLGQRADLTQCTCIAIGYFDVDREGEAPIRDNGRVPDGRNVEVRRVRDIVGGDFRVIVRAIVDEDDEQKDSETLEVLEPEEQEGSGDQEEWTEREEDCDSACSVSEVNHPNNPNFWLCERCYQLLHAWLDKDALPCRNPALHSASEPMSLAGELYEIVNSRAQRRQDADTGLLPCIDYNGIEATLEQWQVHFAPGRRGSRYIAKGIRTGLRGPDLIPAIMRDFRCWMFLQPDLWPEPTGSYPAFVPFQGAHTDLSPIIATLPVELLILIMRELPVESLLSLAATCRLLRGLITDPTFMDRVLREILLYGDIRWILPATPDEIPRAHEVASRWLSEPGTNASGQNFSSPFASPRFPYLAFVYACFQSDSMKNRKRIWGMVKQFEGLWVDYRVRGWEVDRFYPSSDLPWLEKTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPZ4</accession>
    <name>W4JPZ4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_164849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553405.1">
        <property type="nucleotide sequence ID" value="XM_009555110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPZ4"/>
    <dbReference type="GeneID" id="20667941"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_164849"/>
    <dbReference type="HOGENOM" id="CLU_3125243_0_0_1"/>
    <dbReference type="InParanoid" id="W4JPZ4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW74946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="50" mass="5790" checksum="AB08CD7D0DEAE055" modified="2014-03-19" version="1">MLSKTRYPMRKYIHRAARCLHTVALGCCHSYSSVGRCFVVWIRALIHTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQQ9</accession>
    <name>W4JQQ9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome recycling factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_330210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552136.1">
        <property type="nucleotide sequence ID" value="XM_009553841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JQQ9"/>
    <dbReference type="STRING" id="747525.W4JQQ9"/>
    <dbReference type="GeneID" id="20671558"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_330210"/>
    <dbReference type="eggNOG" id="ENOG502SEMN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092155_0_0_1"/>
    <dbReference type="InParanoid" id="W4JQQ9"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982:SF3">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="RIBOSOME RECYCLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome recycling factor" evidence="5">
        <location>
            <begin position="108"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="43"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW75897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="270" mass="29800" checksum="A95795B86A88C1AD" modified="2014-03-19" version="1">MSVFRQGLRSSLINFPRPPPCTHRLVHCSRLSPLPKIISRSYASKAKSKNRDQSSDAPSSKRSPVATSSLVPGSQQALSDPEAQAEHERASAKMSTAVEWFRREAAQLDARASGRVTPQLLSPVRVALPSAEGEGVEDVRVRLEEVATVGVRDGSMLVITVFDVDTLKHVEAALYDSKLPNIVPQRADERTIKIPIPKPTVDSRLAMYHSAARLAEDTRAQIRKQHQASIKKGKYGKHSIEIDEFQKLHDRFIGEVDTVLAQLKKSTGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRF8</accession>
    <name>W4JRF8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_455645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552272.1">
        <property type="nucleotide sequence ID" value="XM_009553977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRF8"/>
    <dbReference type="GeneID" id="20676643"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_455645"/>
    <dbReference type="HOGENOM" id="CLU_847462_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRF8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844951" evidence="2">
        <location>
            <begin position="23"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW76049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="328" mass="33521" checksum="CFDF0E1DD22445E4" modified="2014-03-19" version="1">MFALTRFVALACLLSTAGLASAAPAPTELMLARRGPTPDALSVFTRDLAASLAGAAINVVREDDESLYKREAAPPPPPRPQARPPAQARPPAGGPRPRDAAPPPPPPHPQSPPPPPGPHPRDAAPPPPPRPQAQAQAQAQARPAQARPAAQARPAPAGGPQPRDAAPPPPPPAPKSPPPPPGPGPHPRDAAPPPPPRPQAQAPAPAPAQARPAAQARPAAQARPPAGGPRPRDAAPPPPPPPPSSLPPPPAPHPRDAAPPPPPRPQAARPPAQARPPPATGPRPRDAAPPAPPPPPPPAPPAPPLPPHARGDEQTLYVRRTYVEDYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRI3</accession>
    <name>W4JRI3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_330366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552296.1">
        <property type="nucleotide sequence ID" value="XM_009554001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRI3"/>
    <dbReference type="GeneID" id="20671573"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_330366"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_22_3_1"/>
    <dbReference type="InParanoid" id="W4JRI3"/>
    <dbReference type="OrthoDB" id="446925at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="69"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW76074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="263" mass="29666" checksum="925A159679CEE19A" modified="2014-03-19" version="1">MVAALSSRITILTAAHDDVAHKGFYATTALIAEHFWWPHMRQDISWFVWTCHLCQIHQTRNILIPPTAATPAPLFAEMYMDTMHMPTAGSFKYLMQGHCLVSHYPEFWMLQRETSSALAGWIFKNILCQWGTLVEIVSDNGLAFVKVLDQLAKKYHVWHIHISGYNSCANGIAERPHFDIRQALFKAIDGDQAKWNRAAHFVFWADCITVQCRMGCSPYFAATGTHPLLPLDIAEATYLLPPPTTALSTTILIAQHAIALQKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRT5</accession>
    <name>W4JRT5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_329644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552455.1">
        <property type="nucleotide sequence ID" value="XM_009554160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRT5"/>
    <dbReference type="STRING" id="747525.W4JRT5"/>
    <dbReference type="GeneID" id="20671513"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_329644"/>
    <dbReference type="HOGENOM" id="CLU_1781884_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRT5"/>
    <dbReference type="OrthoDB" id="2343366at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="146" mass="15881" checksum="459132A51988DE0A" modified="2014-03-19" version="1" fragment="single">TAVAQQDRSVKVLNCNILKLLACSHHQIAAKIGYLIACIGHASVGSLHNVICCSLDSNVIDPYSREEQAEFAKCDSMCGGPEHAATASHSFCTQNIFHAPLPLGTVPDNALGYVSHDGHSFDCKDPALLRQSFHVYVFRMISEDMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4JS42</accession>
    <name>W4JS42_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation initiation factor eIF4e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_422374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551965.1">
        <property type="nucleotide sequence ID" value="XM_009553670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JS42"/>
    <dbReference type="STRING" id="747525.W4JS42"/>
    <dbReference type="GeneID" id="20673803"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_422374"/>
    <dbReference type="eggNOG" id="KOG1669">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042809_0_0_1"/>
    <dbReference type="InParanoid" id="W4JS42"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF73">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 4E, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="392"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW75701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="46536" checksum="31C2A14E0F8B8562" modified="2014-03-19" version="1">MAAAPPPAAATTVSKSERAPSGGRLPSLNQLAARIGANSSSSISPVNNRPRLAASLLRTGSTTSLSTTTSTADSTAVNPPITRSTSPGALSISPPNSTAGSVNGDVGEPLTFDKVEKLAQETGDKPPKKVKGYKNIPSLDAITAHYARTRTLSVDGTPVPPEAESIEDPQTPGLMTKAPEHPLQHSWTIYHDTKTKIPFTPAAVVEGANHPAPAEAGVYEAGLTTVGDFDTVESYCRYFNWLKPPSKLDRNSNYHIFKSGIKPMWEDDANANGGKWVLTMKNNPALLDRCWQWLTMALVGEELDETDEICGAVVSLRSKVDRIQLWMRSKDDVERINGIGRKFVKLLDVSEADGIGLEFQYNTEDRPLPNKFLSIQAVPQSSFRSSFHGKTSSVSSPISGPDSMSPVSAGPGAAFAAFSLGGGGALGGGIGGGWRGKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSU0</accession>
    <name>W4JSU0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_442316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552167.1">
        <property type="nucleotide sequence ID" value="XM_009553872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSU0"/>
    <dbReference type="GeneID" id="20675435"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_442316"/>
    <dbReference type="HOGENOM" id="CLU_2049975_0_0_1"/>
    <dbReference type="InParanoid" id="W4JSU0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="120" mass="13055" checksum="F6F37CA59818BC85" modified="2014-03-19" version="1">MEESRSFVEDQVSAENYHQKGTTTAHGWSDHQTEDPRVLGDQMRTKGRHCLSTDTISIPISGELSSPPAAHTIEACHRTPIPIVQRTSPTSAQKAGALIIVILRGPRTGRGSSVSTRIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSU3</accession>
    <name>W4JSU3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_148353</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552386.1">
        <property type="nucleotide sequence ID" value="XM_009554091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSU3"/>
    <dbReference type="STRING" id="747525.W4JSU3"/>
    <dbReference type="GeneID" id="20667263"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_148353"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_27_1_1"/>
    <dbReference type="InParanoid" id="W4JSU3"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="23"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="482"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="492"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW76175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="510" mass="54029" checksum="72407F98F931945A" modified="2014-03-19" version="1">MSSPEDASAFILPVQSKARKFSLLALFCIAQFIDTFSISSLITAIPKISEDLGLSTAQATWLLSGFSLTFASFLLVSGRVSDVYSPKVVFVGGIGALGFISLGAGFLKSKIPLIVLRALGGIAGSMTIPSALALIVAMFPQPLEQSRAISLFGGCGAVGNVAGLIIGGVFTQFATWHWVFWFVTIVAVPISFACIFLIPAQPKSGEPRMQSLKRLDALGVSILTVALVLLIFAMTQGSSSGWGTGGVIAPLIISIFMIAGFFYYETLIPTDMAAIPPATWFIPNFAALFGASLLPYFFWTTQSTLFTELWQGVYHRSAISAAVHTIPSSVVAFALNFTGPLQHRISPKWLIMSGQILMALAGILGTFADGANKYWRFDFLVFIFGSAGAQLIFTHDNVAIFRATPPHMAGTVGAIFNGGLQLGSAVGLAIATSIQASVSQKHGSPDDYSGRAAAYWFIFAAAILGAVAMFFFYHTDGDTAPPSAGNTVTGEEQEKVSDSGKSDVEARASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSZ7</accession>
    <name>W4JSZ7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_480850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551567.1">
        <property type="nucleotide sequence ID" value="XM_009553272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSZ7"/>
    <dbReference type="STRING" id="747525.W4JSZ7"/>
    <dbReference type="GeneID" id="20677936"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_480850"/>
    <dbReference type="eggNOG" id="ENOG502QW40">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025462_0_1_1"/>
    <dbReference type="InParanoid" id="W4JSZ7"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW76687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="386" mass="44604" checksum="D466BB3B08A9D19E" modified="2014-03-19" version="1">MAVTLSYPVLSAICLLSLIPIALHRWVSSRKAAGDSTEEATGKRLNEKTRRLPDPEPLNNLDLKTAQIRNHIYANKTLRHPYFQTMAHQPMNINHWIEIDKDIGWYIDEKTRVIKEQGKTVVDSLPENDDACAELLEILVDYLPKRYPTLFEHIGVNGIWNKITGERFHDLTGKSGVDALVVISRLVQDDFLMGREREDGHVYFVGGLVAFPGFYLLSNYIDKPLEEIHRHIPYFNEKILKSVERTLKRFGPHEPFERTSWGVVDDRNLFYKMIAEQALPNGLRPEDLWLRMDHQTFRKLPRSGGIAFGVHVVLKRLEDLAESPVVPALLAKIHLEADKELMHHKFDGIYRDRMMPYLQELTKRQLEQGLITCVGIRFQTLFSFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JT39</accession>
    <name>W4JT39_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_106063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551510.1">
        <property type="nucleotide sequence ID" value="XM_009553215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JT39"/>
    <dbReference type="GeneID" id="20666129"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_106063"/>
    <dbReference type="HOGENOM" id="CLU_927681_0_0_1"/>
    <dbReference type="InParanoid" id="W4JT39"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="300" mass="32022" checksum="5FB7C143196BD070" modified="2014-03-19" version="1">MLIVHAAPRDSDWPPWRAVRCSEFSTLLPPPPLAWPRRSAKAAGKVYFEFESEFEFKFKFEGSGRRCVTVACGLSLHIARPRAVCAPAPPSFGGLLARPTPALPAGVPTSPHSPAPQSRARAPRGAPFSHAPAHNAEASTADCRLSSAASPRDLRLCLRMRARTPPSRASFSRVVLIALVIRALPCLADLAGLAKHRARRGQRAARVHRPARHVPGSLSSAKPSSGRGAHAAAPRFVLARSLVRACLTLSPPPSTAAEHHGRTDARTGGRAAGQRLAGPVPVPVPVPVLVREFGRQRTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4JT95</accession>
    <name>W4JT95_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_480841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009553269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JT95"/>
    <dbReference type="FunCoup" id="W4JT95">
        <property type="interactions" value="296"/>
    </dbReference>
    <dbReference type="GeneID" id="20677935"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_480841"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_1"/>
    <dbReference type="InParanoid" id="W4JT95"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW76684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="337" mass="37338" checksum="EA6682837D64BD5C" modified="2014-03-19" version="1">MTIKLPTRKIGATDVTAIGYGTMGLSIAYGETGSDEDRFKVLDAVYENGCTNWDTADIYGDSEDLIGKWFKRTGKRDEIFLATKFGLYGPSGKFVEGDPAYVKSSFEKSLKRLGTDHIDLYYFHRADKTIPIEKTVGAMANLVKSGKVKYIGLSEVSESTLRRAHAVHPISALQVEYSPFALDIEDEKIGLLKAARELGIAIVAYSPLGRGLLTGRYKGPEDFEEKDFRRLIPRFSKENFPNILKLVDSLKAIGDKHKVTAGQVTLAWLLGQGDDVIPIPGTQRIKYLEENLGALKVELTREELLVLRKAAESSDAASGDRYPPNFMDVMFSDTPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTL9</accession>
    <name>W4JTL9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_328118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551770.1">
        <property type="nucleotide sequence ID" value="XM_009553475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTL9"/>
    <dbReference type="STRING" id="747525.W4JTL9"/>
    <dbReference type="GeneID" id="20671392"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_328118"/>
    <dbReference type="eggNOG" id="ENOG502SKHB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002498_2_0_1"/>
    <dbReference type="InParanoid" id="W4JTL9"/>
    <dbReference type="OrthoDB" id="2687259at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="547" mass="61199" checksum="C69280762BB61530" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4JU73</accession>
    <name>W4JU73_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_429889</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551330.1">
        <property type="nucleotide sequence ID" value="XM_009553035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JU73"/>
    <dbReference type="GeneID" id="20674388"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_429889"/>
    <dbReference type="eggNOG" id="ENOG502SRX6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035509_11_0_1"/>
    <dbReference type="InParanoid" id="W4JU73"/>
    <dbReference type="OrthoDB" id="3249922at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="17"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW76421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="433" mass="47319" checksum="0EF32B816E90E1ED" modified="2014-03-19" version="1">MPRVLIQTNVNGNITPYSIAGIAALLVYDYICTLDQEIEFVWSGPWSLGKFLFLANRYSPFIDTFISLHLLTSFESPEHCLAQFKVVAWLITLGTLLSEAILMLRTYAIWDRKRWVQVLLLCILLLVFPAAIAVTHIEVASFEYGPSPHPTIPGCTLKKASRIIYIAYVLLMVSETGQSRLLRKSPLADPATVIVALTGIRAIQHLRATRSPLVVALYRDGILFYGYLFAITAMNVIVPVAAPVEFSNWLATPQRVLHSIMCTRVLLFIFRARYAGSHPRSASASASPHAYAAPAGATGSARTDSDAAELTSFAKLTTMFSTVWGPGEGAPDGLGAGTRVGSSSSEEGEGELGSEQWRRRRLRGAGEGDVEEEIEMEVRSERVRGAEEDYERGQGRPSTNAPGGSIETTRALLGRGEEEAQDAIATIGRTRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4JW30</accession>
    <name>W4JW30_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_421274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550637.1">
        <property type="nucleotide sequence ID" value="XM_009552342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JW30"/>
    <dbReference type="GeneID" id="20673716"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_421274"/>
    <dbReference type="HOGENOM" id="CLU_1461503_0_0_1"/>
    <dbReference type="InParanoid" id="W4JW30"/>
    <dbReference type="OrthoDB" id="3269179at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW77091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="185" mass="20014" checksum="EF7C19837E66CFC7" modified="2014-03-19" version="1">MENSMAYCLLMENGRKLRSLTQAVLQCEMNLSPLRRDKRIGGISESIATLCPSILDGRSHSITKTILEGTSAHVGFRLAVKVDNPPEPANLLSSAKAALSNMKSPASPIALAIGASTSALEPVKDFVDNWTALLSQVQTFCELMDGIAEVHPYAKMAWSVISIPQKVFHLDLDDVSRDADQISCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWN9</accession>
    <name>W4JWN9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aryl-alcohol oxidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">aao7</name>
        <name evidence="11" type="ORF">HETIRDRAFT_163945</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549981.1">
        <property type="nucleotide sequence ID" value="XM_009551686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWN9"/>
    <dbReference type="STRING" id="747525.W4JWN9"/>
    <dbReference type="GeneID" id="20667880"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_163945"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_3_1"/>
    <dbReference type="InParanoid" id="W4JWN9"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="9">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW77972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="645" mass="68994" checksum="03BBFB3C1897B8BC" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4JX52</accession>
    <name>W4JX52_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_435975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550132.1">
        <property type="nucleotide sequence ID" value="XM_009551837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JX52"/>
    <dbReference type="STRING" id="747525.W4JX52"/>
    <dbReference type="GeneID" id="20674860"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_435975"/>
    <dbReference type="eggNOG" id="ENOG502SXTU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_636237_0_0_1"/>
    <dbReference type="InParanoid" id="W4JX52"/>
    <dbReference type="OrthoDB" id="3270670at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="431" mass="45287" checksum="A2424D20A297E31C" modified="2014-03-19" version="1">MAVAPPMFTDRRLPLTRNIYYHGVDTRQSPSMVLPDPAWPSTHSNPRPSSAYPDDVPTQLSSWILSPPPPSTSSSWSTDSAFPSSLYSQSSKNTDHYQPGYAGSDSASSYASEYPESSQRTDLAHAISPPSLCASPYTSPYSSSHATIHRTSSKYSLSNAIYTLDQDIHTSSSSPPPPPPARSAPRPHRPARRSPAVKIEQEDPPHDPFVHETAPAQSSAPPHAQTESQVPLRATQASTEMRQMMGVFRLNPFATQGAFGGPAARASSAEEATALEEEGSVIEFQLELDGACAPRTPSPPPNGLLLRKLSPGVSPGASCYGGHGGGGVDRRGSPVGLQAQAQGGGGGMQGGGWSYELPSEIAAYPLLTASQSQAQAHSPLSMAHVAFGHALVEGGGSTGPSGEPVGKCSDAVSLRGRGRERFREVQSSVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JX54</accession>
    <name>W4JX54_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_411292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550140.1">
        <property type="nucleotide sequence ID" value="XM_009551845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JX54"/>
    <dbReference type="GeneID" id="20672941"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_411292"/>
    <dbReference type="eggNOG" id="ENOG502SQ6G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045014_0_0_1"/>
    <dbReference type="InParanoid" id="W4JX54"/>
    <dbReference type="OrthoDB" id="5311491at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="39325" checksum="47A40EBFBEEED099" modified="2014-03-19" version="1">MPLAPVDNKGTQLYYEDTGAVEGVSYTTLIIVHGTGIHGAFFRPMLSFAAQNNLRVVLVNRRDYPGSTPISDEELATIGKGSTPEAQSAFMTSRGLEIVEFLAWFVKSQDIPPISHGDGKMEGGLAVVAWSSANATFLALFSHLDQVSSENRDLLESYFRTYVFYDGPRWAIGYPHIEGFSRPFYTVTTEHERFEVFKSWISAYYQHPNIEARSLAGLTDKALVKEKVATFSRMTPEEIDAVTSRTALFHSEPLVRTIDPDVFGAHMRKALFDKEMARVWPGTQVKLLQCSESLWETLHVLWELEALYDENRANGSSGRAMEFHMMTEANHCAQWDEPERLTRLLATIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXL8</accession>
    <name>W4JXL8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit OST5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_454296</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the OST5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550286.1">
        <property type="nucleotide sequence ID" value="XM_009551991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXL8"/>
    <dbReference type="STRING" id="747525.W4JXL8"/>
    <dbReference type="GeneID" id="20676492"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_454296"/>
    <dbReference type="eggNOG" id="ENOG502SDRX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166320_0_0_1"/>
    <dbReference type="InParanoid" id="W4JXL8"/>
    <dbReference type="OrthoDB" id="2503643at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007915">
        <property type="entry name" value="TMEM258/Ost5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05251">
        <property type="entry name" value="Ost5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW78307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="92" mass="9737" checksum="F2A3F0FD9D44C01D" modified="2014-03-19" version="1">MSQDTAAAYDAIKAGHLDQLHQSLPAFSPYIAVGLLPYIAFFLLTATFALAFYFSTLSKDTLPVRETVVALTASALGGFGVVALFCTVGVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYL3</accession>
    <name>W4JYL3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cysteine-rich PDZ-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cysteine-rich interactor of PDZ three</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_155876</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRIPT family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548961.1">
        <property type="nucleotide sequence ID" value="XM_009550666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYL3"/>
    <dbReference type="STRING" id="747525.W4JYL3"/>
    <dbReference type="GeneID" id="20667599"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_155876"/>
    <dbReference type="eggNOG" id="KOG3476">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133934_0_0_1"/>
    <dbReference type="InParanoid" id="W4JYL3"/>
    <dbReference type="OrthoDB" id="147332at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019367">
        <property type="entry name" value="PDZ-binding_CRIPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805:SF1">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10235">
        <property type="entry name" value="Cript"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="15"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW78638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="104" mass="11183" checksum="EBE2496B099D0822" modified="2014-03-19" version="1">MVCKKCEKKLSKVAAPDPFTSTSSSIKDGSRKVGENKLIGRPGPSKAGGSKSRFQPYGGKCKDCKQTVTQNRAKYCHGCAFKKGLCSICGKQILDTTGYAMQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYN2</accession>
    <name>W4JYN2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="5">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HETIRDRAFT_386831</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="5"/>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548976.1">
        <property type="nucleotide sequence ID" value="XM_009550681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYN2"/>
    <dbReference type="FunCoup" id="W4JYN2">
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    </dbReference>
    <dbReference type="STRING" id="747525.W4JYN2"/>
    <dbReference type="GeneID" id="20672293"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_386831"/>
    <dbReference type="eggNOG" id="KOG0625">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009330_0_1_1"/>
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    <dbReference type="OrthoDB" id="2291at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="P:carbohydrate metabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
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        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
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    <dbReference type="InterPro" id="IPR045244">
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    </dbReference>
    <dbReference type="NCBIfam" id="NF005737">
        <property type="entry name" value="PRK07564.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF2">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PGM1_C_vert_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PGM_PMM"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="13">
        <location>
            <begin position="16"/>
            <end position="154"/>
        </location>
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    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="14">
        <location>
            <begin position="186"/>
            <end position="289"/>
        </location>
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        <location>
            <begin position="301"/>
            <end position="404"/>
        </location>
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        <location>
            <begin position="1"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW78658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="562" mass="60875" checksum="902B2E2985A97C19" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZA3</accession>
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        </submittedName>
    </protein>
    <gene>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_388485"/>
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    <dbReference type="InParanoid" id="W4JZA3"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="131" mass="15086" checksum="3386FF8383086434" modified="2014-03-19" version="1" fragment="single">MDMEAINKVISMKGQVSRMEKELAALQAQLKDIPTWTRLSSTDPYLSKIKIEWDPEVQQRRAEEDEARRQQPTVPETIDLIETPEAEESNAPGDTKEGSASKYRQKYRALKQSHKELKQIVKTLCTRLEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZF9</accession>
    <name>W4JZF9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA endonuclease activator Ctp1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_324863</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550436.1">
        <property type="nucleotide sequence ID" value="XM_009552141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZF9"/>
    <dbReference type="STRING" id="747525.W4JZF9"/>
    <dbReference type="GeneID" id="20671089"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_324863"/>
    <dbReference type="eggNOG" id="ENOG502S92Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121088_0_0_1"/>
    <dbReference type="InParanoid" id="W4JZF9"/>
    <dbReference type="OrthoDB" id="5801062at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010792">
        <property type="term" value="P:DNA double-strand break processing involved in repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013882">
        <property type="entry name" value="Ctp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033316">
        <property type="entry name" value="RBBP8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15107:SF0">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15107">
        <property type="entry name" value="RETINOBLASTOMA BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08573">
        <property type="entry name" value="SAE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA endonuclease activator Ctp1 C-terminal" evidence="5">
        <location>
            <begin position="19"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="51"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW78470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="146" mass="17035" checksum="3AB208483C56EBAB" modified="2014-03-19" version="1" fragment="single">TINAQYEINPDVNEKLDYQFDEVVRGRQARQRLHGTDCDCCRDYYEAVGPLPPRLSAPMWRSPSPSPARPAERQDAIDSHKQEISRHRQQWQRGNTPPDFWVIGFPDTQAASRINAQAEQMHKEKVEMVERETRKEGGMYRKRGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4K031</accession>
    <name>W4K031_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptide hydrolase</fullName>
            <ecNumber evidence="10">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_124577</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="10"/>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549011.1">
        <property type="nucleotide sequence ID" value="XM_009550716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K031"/>
    <dbReference type="GeneID" id="20666881"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_124577"/>
    <dbReference type="eggNOG" id="ENOG502R701">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047420_0_0_1"/>
    <dbReference type="InParanoid" id="W4K031"/>
    <dbReference type="OrthoDB" id="10013407at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05642">
        <property type="entry name" value="M28_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF26">
        <property type="entry name" value="PEPTIDASE M28 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="368"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW78695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="453" mass="48656" checksum="AADE760F0FCB998F" modified="2014-03-19" version="1">MRDKILRYLYLASSVLNWPRGPGNLLESQPPGDELKAMLDQVDPRRVQTIIEKLVSFGTRHTASSQTDPNTGIGAARDWIAGQMREFASGSAGRMTVSVPSYIQAPVSGEFISSVNISNIVARLEGTTDPNRVYVVSGHYDSRNTNILDSTGDAPGADDDASGVAVSMELARIMATHETAATILFVAVAGEEQGLYGSTFLAQSLRSAGADVQAAFTNDIVGSSTADDGSKDPFSIRLFAQGIPSNETAAQVQARATIGGENDSPARQIGRFVSEVASNSATNMTVRVIYRLDRYLRGGDHKPFLALGYPGARFTEPHENFAHQHQNVRVEDGVQFGDLIEFCDFDFIARVARVNLATMFSLASAPGTPKNVTVDNSVLTNNSTLRWALGEDSGLAGYEILWRATDEPFWTHVIAVGLVSSATVELSKDNAIFGVRAVGQNGFRSPATFPFPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0E6</accession>
    <name>W4K0E6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_478059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549090.1">
        <property type="nucleotide sequence ID" value="XM_009550795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0E6"/>
    <dbReference type="GeneID" id="20677800"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_478059"/>
    <dbReference type="HOGENOM" id="CLU_2558559_0_0_1"/>
    <dbReference type="InParanoid" id="W4K0E6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="82" mass="8904" checksum="D459AB53B7504372" modified="2014-03-19" version="1">MEVDVAKDGGNDVAESVVVEEEQETEGASASAIAENPTENPEPVFVLHKIATLDLENDKLIVFSAVGFVFSYKNFLLFPLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1R8</accession>
    <name>W4K1R8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RED-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_435542</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1R8"/>
    <dbReference type="STRING" id="747525.W4K1R8"/>
    <dbReference type="GeneID" id="20674832"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_435542"/>
    <dbReference type="eggNOG" id="KOG2498">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048753_0_0_1"/>
    <dbReference type="InParanoid" id="W4K1R8"/>
    <dbReference type="OrthoDB" id="3366823at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039896">
        <property type="entry name" value="Red-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012916">
        <property type="entry name" value="RED_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12765">
        <property type="entry name" value="RED PROTEIN IK FACTOR CYTOKINE IK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07808">
        <property type="entry name" value="RED_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RED-like N-terminal" evidence="5">
        <location>
            <begin position="39"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="136"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW79041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="436" mass="47515" checksum="A2DBF795D499FF5F" modified="2014-03-19" version="1">MRSRGQAPIQSSKRKYTEIHAFSWISATVSASEPAFKPRKLKKQSEKYRNRAEERRAGADHDYSQIEAVLEDFERQNADKEDRAAVEAQRSYLGGDSDHSILVKGLDFALLEQNKARLASASSKLDDQLLEEAFKETAVASTSSESLNPTSKKRSRTDILRELKEKRGSMEGVAPAKAQEESIASANVSAKFRPIGFKPIGPPAEEKAKKKKKVKAQDGDGAERKKKRRKVEKGESQKGEMGPPAVPIKDSPSAANAPSSTTTAPTVQKPDMEPESIDEDLDIFAGAGEYEGIDLGDDDDDDGDDNNNNGGEGRHREASPADEGLSTATSGRKWFDDAPQSEQPKSSTETATQATVNSPPPPPDLEEGEEETPMRLVPLASSAVPSISDLLAMDEAAEKETKRKARKEKKKGKGGGDKLDRDYQRLKSYEAKKAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1V1</accession>
    <name>W4K1V1_HETIT</name>
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        <submittedName>
            <fullName evidence="6">Mitochondrial import inner membrane translocase</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">HETIRDRAFT_64392</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548815.1">
        <property type="nucleotide sequence ID" value="XM_009550520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1V1"/>
    <dbReference type="FunCoup" id="W4K1V1">
        <property type="interactions" value="539"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K1V1"/>
    <dbReference type="GeneID" id="20678678"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_64392"/>
    <dbReference type="eggNOG" id="KOG3324">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063935_0_0_1"/>
    <dbReference type="InParanoid" id="W4K1V1"/>
    <dbReference type="OrthoDB" id="159299at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF0">
        <property type="entry name" value="SD19278P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW79086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="214" mass="22057" checksum="E861027D366E01A3" modified="2014-03-19" version="1">MSSPGSNSQPSSSQDPTEYLRNASFSRSESSAPLPESMSASDVLMGAYDPAKLHPLAGLGDQLDYLMLDDDKTNDLPGSGTAIPSRGWSDDLCYGTGTMYLGGLALGGAWGVREGARRPLAVSNTRLRINSVLNAVTRRGTFLGNSAGVLALAYNGINSTIDGVRGKHDTLGSMAAGALTGALYKSSAGVKPALAAATLVSGLAGAWSYAKRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1W0</accession>
    <name>W4K1W0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_49035</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547936.1">
        <property type="nucleotide sequence ID" value="XM_009549641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1W0"/>
    <dbReference type="FunCoup" id="W4K1W0">
        <property type="interactions" value="915"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K1W0"/>
    <dbReference type="GeneID" id="20678094"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_49035"/>
    <dbReference type="eggNOG" id="KOG1872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017549_2_1_1"/>
    <dbReference type="InParanoid" id="W4K1W0"/>
    <dbReference type="OrthoDB" id="333239at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02657">
        <property type="entry name" value="Peptidase_C19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16104">
        <property type="entry name" value="Ubl_USP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF1">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="2"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="105"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW79793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="537" mass="59124" checksum="F8AE2D74BEF05938" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1W2</accession>
    <name>W4K1W2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_387660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549568.1">
        <property type="nucleotide sequence ID" value="XM_009551273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1W2"/>
    <dbReference type="STRING" id="747525.W4K1W2"/>
    <dbReference type="GeneID" id="20672324"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_387660"/>
    <dbReference type="eggNOG" id="KOG2793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052836_0_0_1"/>
    <dbReference type="InParanoid" id="W4K1W2"/>
    <dbReference type="OrthoDB" id="413520at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF162">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="44521" checksum="6A9EEA434BDF14B3" modified="2014-03-19" version="1">MYYYLSFLRPPPLQSSLSAPITITPQVSNDLRTEPLLDPLDIFYFWTLPPPASPTPLSTPVKLTTWRSANAYKELSIPPPPCVRDGMRFCLVLTTSPAMQPSPSEIDLRTHCTRISAPFPVSSLPIAFSLRMPKGKIPKQESIIRAFRFSDAEGSLVRVREQTSFDLDKKLWDSGIGLSAWLTELHASSTHPKNPKTHPLVNKAMTILFKKENCEIIELGAGTGVVSLTMAALRSADASLSEYPARILTTDLPSSMEVMEHNITQNDSLFTARVPVALVLDWDGGLPPQVLDVGSRGGFDMIVMADVTYNTSSFPALVNTLSALLALSPKSTTSDASESTADESEITKTAQNANAEAPLILLAYKQRDSAERELWELLREKTGVQLVQINALPGAGGEAVEIWVGQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1W7</accession>
    <name>W4K1W7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS monocarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_64624</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548824.1">
        <property type="nucleotide sequence ID" value="XM_009550529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1W7"/>
    <dbReference type="GeneID" id="20678687"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_64624"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="InParanoid" id="W4K1W7"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF305">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="252"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW79330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="447" mass="47072" checksum="80077C51ACCCAB70" modified="2014-03-19" version="1">MQLDILHRNPEATSRKSENRVANAIVEAADSRGDGSQAINIQATIDDLPDGGYGWVIVAACSLISFFHIGLTYSWGIVQARLSASHLAKDSTLSFIGSTAVAFVSFAALVNARIIRRLGTRNSALLGCFSLGFGQILNGWASYSIAGLFVTNGVIVGFGTSLCFMTCGSLPAQYFKRRRGLANGFVFAGGGIGGGVWSLSISSLIDRVGIPWTFRILGLITLTTTMPAAMLLKERVRRAPATVEWRLFLDPKFILLFLGSALATFPILVPAFFIPLYANSLGASAFTASALLALFNLSSAVGRVGFGALGDRIGPISALALTLLLAAVSMLAIWPVSASLAPLVVFIVLNGIGNGGFFSTMPSVIGHMYGSSRVASALAMVVTGWAFGYLLGSPVAGWLLDAYGGSSAGRTAFRPAIYFAGSLSLLSVVLITAMRHMVTKNKIFVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1X2</accession>
    <name>W4K1X2_HETIT</name>
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        <recommendedName>
            <fullName evidence="4">Actin interacting protein 3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="5" type="ORF">HETIRDRAFT_49645</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548753.1">
        <property type="nucleotide sequence ID" value="XM_009550458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1X2"/>
    <dbReference type="FunCoup" id="W4K1X2">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K1X2"/>
    <dbReference type="GeneID" id="20678117"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_49645"/>
    <dbReference type="eggNOG" id="ENOG502QS95">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005287_0_0_1"/>
    <dbReference type="InParanoid" id="W4K1X2"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005519">
        <property type="term" value="F:cytoskeletal regulatory protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1540">
        <property type="entry name" value="Actin interacting protein 3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022782">
        <property type="entry name" value="AIP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005613">
        <property type="entry name" value="AIP3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056279">
        <property type="entry name" value="Aip3p_Bud6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051825">
        <property type="entry name" value="SRCIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741:SF10">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741">
        <property type="entry name" value="P140CAP/SNIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03915">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23153">
        <property type="entry name" value="Aip3p_Bud6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00806">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Actin interacting protein 3 C-terminal" evidence="4">
        <location>
            <begin position="238"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="114"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="653"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="436"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="654"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="665"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW79335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="675" mass="74456" checksum="745A0C2ECFD6123B" modified="2014-03-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2H6</accession>
    <name>W4K2H6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_117037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548537.1">
        <property type="nucleotide sequence ID" value="XM_009550242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2H6"/>
    <dbReference type="GeneID" id="20666533"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_117037"/>
    <dbReference type="HOGENOM" id="CLU_037970_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2H6"/>
    <dbReference type="OrthoDB" id="3172239at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW80012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="574" mass="63487" checksum="2537526DD5ACF21C" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3R1</accession>
    <name>W4K3R1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative B mating type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_147163</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548269.1">
        <property type="nucleotide sequence ID" value="XM_009549974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3R1"/>
    <dbReference type="STRING" id="747525.W4K3R1"/>
    <dbReference type="GeneID" id="20667186"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_147163"/>
    <dbReference type="eggNOG" id="ENOG502SPJ7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027592_1_0_1"/>
    <dbReference type="InParanoid" id="W4K3R1"/>
    <dbReference type="OrthoDB" id="2874149at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004932">
        <property type="term" value="F:mating-type factor pheromone receptor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="7tmD_STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097:SF1">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00899">
        <property type="entry name" value="GPCRSTE3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="149"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="385"/>
            <end position="475"/>
        </location>
    </feature>
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        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
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        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW79706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="577" mass="63485" checksum="83BD9683EB19AF4C" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3V4</accession>
    <name>W4K3V4_HETIT</name>
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        <submittedName>
            <fullName evidence="11">Cytochrome P450 monooxygenase 105</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cpm105</name>
        <name evidence="11" type="ORF">HETIRDRAFT_321457</name>
    </gene>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009550003.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_321457"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450I"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW79741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="516" mass="57992" checksum="9FE832B008FA3D50" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4C7</accession>
    <name>W4K4C7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_101736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009549032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4C7"/>
    <dbReference type="GeneID" id="20665791"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_101736"/>
    <dbReference type="HOGENOM" id="CLU_1510809_0_0_1"/>
    <dbReference type="InParanoid" id="W4K4C7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="178" mass="19659" checksum="366077FF5C4780EB" modified="2014-03-19" version="1">MGWVSRADEMGHVYIGQLPAYCSEALRASCDQPPPLAARGFYTHHLSRPSPSRHPRHPSPSAPRCCCCCCPSDSPEQPNHTPSRHAGPMIAWRCLHILSSSSRTQRAFRVTFFPTSSHANRSSCRHTQSPTRPLSRLSPLASPYLFSNPPAHLRLDVPTHASSLRSLISFSPIEQALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4W2</accession>
    <name>W4K4W2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_123228</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547367.1">
        <property type="nucleotide sequence ID" value="XM_009549072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5K7"/>
    <dbReference type="GeneID" id="20677675"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_476330"/>
    <dbReference type="eggNOG" id="ENOG502S8VS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036221_0_0_1"/>
    <dbReference type="InParanoid" id="W4K5K7"/>
    <dbReference type="OrthoDB" id="2107166at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045030">
        <property type="entry name" value="LYSM1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932:SF8">
        <property type="entry name" value="LD22649P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932">
        <property type="entry name" value="LYSM AND PUTATIVE PEPTIDOGLYCAN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="58"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW80645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="359" mass="38549" checksum="C761F103DAFCC7EB" modified="2014-03-19" version="1">MSASTLGDTSHHDTRPHLARLLSLWEKDSSPANHDKLEGAHAGSSSGLGRGAEERVVLVHEVMPKDSLAGVALKYGITVAELRRSNQLWASDSIHLRKVLYIPLGHAKLPFLDAAVTPDNITVNLQSRSATSIPEDISPDSASHGARRTFSSYTVRRIPATRLSFFPPSQPTLPSTSPARSLYPFPAAHPSASPVPPHESLQIPARESFLRSSSTAVGATLRPHALSSLVSALPFSASTRDEIISRLSFESASTSTTGTGSDEDDLELTTVPPTPHSRPKYTSPVPFVAPQRRRRGPRTGQDASSPVPEEIALVQSVGPVRTVQMEPIPAMQLPSRMSRSSNMPKSGQDSGLVKHSVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5V8</accession>
    <name>W4K5V8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Metallo peptidase M24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_440646</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547822.1">
        <property type="nucleotide sequence ID" value="XM_009549527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5V8"/>
    <dbReference type="STRING" id="747525.W4K5V8"/>
    <dbReference type="GeneID" id="20675290"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_440646"/>
    <dbReference type="eggNOG" id="KOG2413">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011781_2_1_1"/>
    <dbReference type="InParanoid" id="W4K5V8"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000007">
        <property type="entry name" value="Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF17">
        <property type="entry name" value="AMINOPEPTIDASE P, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="7">
        <location>
            <begin position="22"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="6">
        <location>
            <begin position="309"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="8">
        <location>
            <begin position="533"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW81154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="610" mass="68907" checksum="996542D603E56F95" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4K602</accession>
    <name>W4K602_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycoside hydrolase family 31 TIM barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_451080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545912.1">
        <property type="nucleotide sequence ID" value="XM_009547617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K602"/>
    <dbReference type="STRING" id="747525.W4K602"/>
    <dbReference type="GeneID" id="20676110"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_451080"/>
    <dbReference type="eggNOG" id="KOG1065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2527729_0_0_1"/>
    <dbReference type="InParanoid" id="W4K602"/>
    <dbReference type="OrthoDB" id="2790169at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF133">
        <property type="entry name" value="P-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="3">
        <location>
            <begin position="14"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW81238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="84" mass="9192" checksum="8793841EA1CB2EAC" modified="2014-03-19" version="1">MKAVGEVKGQPASGYVELDTHNIFGYMEGRATNLALRAVHPGERPFIIACSTFPGSGHWTGHWPGDNYSKWAYMAHSIAGVLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W4K674</accession>
    <name>W4K674_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Nitrate reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">HETIRDRAFT_383634</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>nitrite + NADP(+) + H2O = nitrate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19061"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="17">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the nitrate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545961.1">
        <property type="nucleotide sequence ID" value="XM_009547666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K674"/>
    <dbReference type="STRING" id="747525.W4K674"/>
    <dbReference type="GeneID" id="20672163"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_383634"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_4_0_1"/>
    <dbReference type="InParanoid" id="W4K674"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050464">
        <property type="term" value="F:nitrate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006809">
        <property type="term" value="P:nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.420.10:FF:000003">
        <property type="entry name" value="Nitrate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012137">
        <property type="entry name" value="Nitr_rd_NADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000233">
        <property type="entry name" value="Nitr_rd_NADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 17" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="13 16" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="20">
        <location>
            <begin position="509"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="21">
        <location>
            <begin position="604"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ETW81288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="868" mass="97816" checksum="8DC0B61835779A39" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4K687</accession>
    <name>W4K687_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Meiotic nuclear division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_452150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MND1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547316.1">
        <property type="nucleotide sequence ID" value="XM_009549021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K687"/>
    <dbReference type="FunCoup" id="W4K687">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K687"/>
    <dbReference type="GeneID" id="20676227"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_452150"/>
    <dbReference type="eggNOG" id="KOG3433">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080628_3_1_1"/>
    <dbReference type="InParanoid" id="W4K687"/>
    <dbReference type="OrthoDB" id="273345at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040661">
        <property type="entry name" value="LZ3wCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005647">
        <property type="entry name" value="Mnd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040453">
        <property type="entry name" value="Mnd1_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18517">
        <property type="entry name" value="LZ3wCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03962">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026991">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mnd1 HTH" evidence="6">
        <location>
            <begin position="47"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine zipper with capping helix" evidence="7">
        <location>
            <begin position="205"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW80586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="28851" checksum="560498112D9A6B6D" modified="2014-03-19" version="1">MDEINLGLGLGHETGLIWSRVWARRGLRRALAPRGLSAEEKRVKLVEIFHETLKELEKLGPKMKGIGTSRPTRESARSLVDDGLVQTDKVGSSNCASGSLRRIDVFWSFPSQRGTIMQNRLDAAKEAEKNHQKQIADTEENMKTEHAARIESVSILRLDARELSTKCAIQAERTSSLAKLSALKQQAAELETELQAYGACDPTKVEEKKRAVTLAKEAAVRWTDNYSILLAHFTRQNGVEAEEVRKYLGVSDDYEDIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6A1</accession>
    <name>W4K6A1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_173037</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546013.1">
        <property type="nucleotide sequence ID" value="XM_009547718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6A1"/>
    <dbReference type="STRING" id="747525.W4K6A1"/>
    <dbReference type="GeneID" id="20668418"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_173037"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_1"/>
    <dbReference type="InParanoid" id="W4K6A1"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000374">
        <property type="entry name" value="3-oxoacyl-(Acyl-carrier-protein) reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="10"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW81352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="255" mass="26512" checksum="9A9C595224B0E577" modified="2014-03-19" version="1">MSSPLPLAGKVAIVTGSSRSIGASIATKLAADGASVVINYVSPSSAPLAAHLVAQIKSSGTGDAVAVKADLSTLEGGQRLLAEALRAFGKLDVLVLNAGIMGSRVLQDVDEAFFDAHFDINVKGPLFLTKAAAPLLPPGGRIVFFSSSLTSASAVQPNALVYVASKAAIEQFARVLAKDLAPRSITVNVVSPGPIDTDLFRRDKTEQQIQFITNLNPHKRLGEVDEVAPVVAFLASEGAKWVTGQNIRVNGGFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7S8</accession>
    <name>W4K7S8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_419046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547802.1">
        <property type="nucleotide sequence ID" value="XM_009549507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7S8"/>
    <dbReference type="GeneID" id="20673521"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_419046"/>
    <dbReference type="HOGENOM" id="CLU_2158757_0_0_1"/>
    <dbReference type="InParanoid" id="W4K7S8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="111" mass="12167" checksum="7718664AA86612B3" modified="2014-03-19" version="1">MTSGHVVPSYLYPPTVFPGWQQARTSVEIIQILARSAKSLGLEPSAVEPRFFKDPSLGNGKRHTQKSYPAELPQAQRFYSSSTSAMSGSPKLSLRRRACSSDNPIKTIKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8P7</accession>
    <name>W4K8P7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_451441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546334.1">
        <property type="nucleotide sequence ID" value="XM_009548039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8P7"/>
    <dbReference type="GeneID" id="20676154"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_451441"/>
    <dbReference type="HOGENOM" id="CLU_334953_0_0_1"/>
    <dbReference type="InParanoid" id="W4K8P7"/>
    <dbReference type="OrthoDB" id="3037908at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="724"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="775"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="804"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW81720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="852" mass="92467" checksum="65AFED31E73141BA" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9L9</accession>
    <name>W4K9L9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_36827</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Peripheral membrane protein</topology>
            <orientation evidence="1 11">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545788.1">
        <property type="nucleotide sequence ID" value="XM_009547493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9L9"/>
    <dbReference type="FunCoup" id="W4K9L9">
        <property type="interactions" value="436"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K9L9"/>
    <dbReference type="GeneID" id="20671832"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_36827"/>
    <dbReference type="eggNOG" id="KOG3479">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141397_3_0_1"/>
    <dbReference type="InParanoid" id="W4K9L9"/>
    <dbReference type="OrthoDB" id="1551503at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050673">
        <property type="entry name" value="Mito_inner_translocase_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13172">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="12">
        <location>
            <begin position="17"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW81766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="89" mass="10288" checksum="9A0BB6CAFDD0C917" modified="2014-03-19" version="1">MDFSQFNAAEQAHMSKVIEKKQMQDFMRMYSSLVERCFNSCCNDFTSKALSTKEEQCMLNCADKFLKHSERVGARFAEQNAEAMNALQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9R1</accession>
    <name>W4K9R1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_434237</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546601.1">
        <property type="nucleotide sequence ID" value="XM_009548306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAB2"/>
    <dbReference type="GeneID" id="20665767"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_101443"/>
    <dbReference type="HOGENOM" id="CLU_1686829_0_0_1"/>
    <dbReference type="InParanoid" id="W4KAB2"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="156" mass="16761" checksum="A51D1CE15AD586BD" modified="2014-03-19" version="1">MLVAFFCSSAASKPAPNSRSEAIDDACMPGQLRLDTGAASMGVLSMHHAHPGIGRLRPSPLALGQPPRPISLVHQAVCRLTSTPTGSRFAELARADAVRLRFALKRPPSNFEFRISEASSSPRRRSVGSTLLEPRVDSSLRLRTIEQLSAPPLLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBA8</accession>
    <name>W4KBA8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exoribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_163547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545414.1">
        <property type="nucleotide sequence ID" value="XM_009547119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBA8"/>
    <dbReference type="FunCoup" id="W4KBA8">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KBA8"/>
    <dbReference type="GeneID" id="20667851"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_163547"/>
    <dbReference type="eggNOG" id="KOG2102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002512_2_0_1"/>
    <dbReference type="InParanoid" id="W4KBA8"/>
    <dbReference type="OrthoDB" id="2285229at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF65">
        <property type="entry name" value="EXORIBONUCLEASE CYT-4, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="1">
        <location>
            <begin position="477"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="959" mass="107671" checksum="FD43BCEDAD2D2C82" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCE1</accession>
    <name>W4KCE1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbohydrate esterase family 16 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_416817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545069.1">
        <property type="nucleotide sequence ID" value="XM_009546774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCE1"/>
    <dbReference type="GeneID" id="20673364"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_416817"/>
    <dbReference type="eggNOG" id="ENOG502SKVX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053747_0_0_1"/>
    <dbReference type="InParanoid" id="W4KCE1"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845299" description="Carbohydrate esterase family 16 protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="37536" checksum="C3A53A3F63CFB8F7" modified="2014-03-19" version="1">MRCKVMLILSCFIVSIAPLSLATPFWDWQADYNDGVHLAVSPECGELGGNFTDVNAGIDLRKIKTIVSFGDSYTDSGKHDGSPLLPPVLTPPDPHAGGRYSDGPMWLENIANDINAKYMAYAWSGAVVNGSLWPSKPSTTTDFISQVSRFLNQSNDLDPHTTLYTVFFGINDWVASQTDGDHLPEDAQYLLNQIRILASPPTNARNILVTDVYGRGAHTPSGEAWKQSIFDGLSAFNSGTNGAPPLNVAFGDFSRIWDGVLGTAPGYAAFGYTSSGSCLPFTNTTEGECDDPKHTFYWLHGCELLHEVQASIFIAESLFLFSGIRQMKRDGSWLIMLKKCSKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCH2</accession>
    <name>W4KCH2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_426713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545719.1">
        <property type="nucleotide sequence ID" value="XM_009547424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCH2"/>
    <dbReference type="GeneID" id="20674139"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_426713"/>
    <dbReference type="HOGENOM" id="CLU_392805_0_0_1"/>
    <dbReference type="InParanoid" id="W4KCH2"/>
    <dbReference type="OrthoDB" id="5569250at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="702" mass="77771" checksum="6CF774A745729EA1" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDD3</accession>
    <name>W4KDD3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_426508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545385.1">
        <property type="nucleotide sequence ID" value="XM_009547090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDD3"/>
    <dbReference type="GeneID" id="20674120"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_426508"/>
    <dbReference type="eggNOG" id="ENOG502SBHA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078285_0_0_1"/>
    <dbReference type="InParanoid" id="W4KDD3"/>
    <dbReference type="OrthoDB" id="5529571at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013262">
        <property type="entry name" value="OMP_MIM1/TOM13_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28241">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28241:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08219">
        <property type="entry name" value="TOM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="327" mass="35563" checksum="49BEFD0D03502617" modified="2014-03-19" version="1">MADHSSPLQSDGEDLLQAALSDAFSISDLPRESAVTQTSYSQDSEPKSEAVAESAEGTEGASPPPASAEQHDAWKAEYEANVAQWRRQSAEARERSEAERARWEEVRAREREEARLRPPPEVKEKVESESGWESVSGITESTGHHSVLPGASSARTNIGIQTQHAPENTTPPSNANDSHPSSSAHWDDFPSSMTSSFPSMSFPEASRSHSPEHHHRHPADQTHHVHDSHAPAHTPHSHTRAHEHASASASTTLAVFDGTLSVRTRAWALVSSLTINMFLPFVNGVMLGFGEIFARNVVGWLGWRVPGAAAANVGIRPLADQRKKRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDM5</accession>
    <name>W4KDM5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_381089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543580.1">
        <property type="nucleotide sequence ID" value="XM_009545285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDM5"/>
    <dbReference type="STRING" id="747525.W4KDM5"/>
    <dbReference type="GeneID" id="20672050"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_381089"/>
    <dbReference type="HOGENOM" id="CLU_457862_0_0_1"/>
    <dbReference type="InParanoid" id="W4KDM5"/>
    <dbReference type="OrthoDB" id="286814at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF27">
        <property type="entry name" value="PHO85 CYCLIN CLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW83839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="596" mass="66165" checksum="4C2DC0E75332D32F" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDN3</accession>
    <name>W4KDN3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_313992</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543688.1">
        <property type="nucleotide sequence ID" value="XM_009545393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDN3"/>
    <dbReference type="FunCoup" id="W4KDN3">
        <property type="interactions" value="317"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KDN3"/>
    <dbReference type="GeneID" id="20670078"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_313992"/>
    <dbReference type="eggNOG" id="KOG0934">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061221_0_0_1"/>
    <dbReference type="InParanoid" id="W4KDN3"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000007">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW83962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="159" mass="18471" checksum="09022C9DF13FD339" modified="2014-03-19" version="1">MINYILLVSRQGKVRLAKWFTTMQPKAKAKIVKDVTQLVLARRTRMCNFLEYKDTKVVYRRYASLFFVCGIGQMDNELITLEIIHRYVEVLDRYFGNVCELDLIFNFQKAYAILDELIISGELQESSKKSVLRVVTQSDSVEEQENSEDTMARLGSRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W4KE60</accession>
    <name>W4KE60_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial</fullName>
            <shortName evidence="7">Glu-AdT subunit B</shortName>
            <ecNumber evidence="7">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_312503</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="7"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543808.1">
        <property type="nucleotide sequence ID" value="XM_009545513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KE60"/>
    <dbReference type="FunCoup" id="W4KE60">
        <property type="interactions" value="302"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KE60"/>
    <dbReference type="GeneID" id="20669960"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_312503"/>
    <dbReference type="eggNOG" id="KOG2438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019240_4_0_1"/>
    <dbReference type="InParanoid" id="W4KE60"/>
    <dbReference type="OrthoDB" id="1722066at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="GatB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004012">
        <property type="entry name" value="PRK05477.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004014">
        <property type="entry name" value="PRK05477.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="GLUTAMYL-TRNA GLN AMIDOTRANSFERASE SUBUNIT B MITOCHONDRIAL AND PROKARYOTIC PET112-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asn/Gln amidotransferase" evidence="8">
        <location>
            <begin position="374"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW84098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="521" mass="57607" checksum="ADD222C72FE21F93" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4KE79</accession>
    <name>W4KE79_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_313773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543767.1">
        <property type="nucleotide sequence ID" value="XM_009545472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KE79"/>
    <dbReference type="STRING" id="747525.W4KE79"/>
    <dbReference type="GeneID" id="20670062"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_313773"/>
    <dbReference type="eggNOG" id="ENOG502S36Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_527449_0_0_1"/>
    <dbReference type="InParanoid" id="W4KE79"/>
    <dbReference type="OrthoDB" id="10250130at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244:SF471">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244">
        <property type="entry name" value="KELCH REPEAT DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844189" evidence="1">
        <location>
            <begin position="30"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="474" mass="49438" checksum="7091CEC85C3B1A27" modified="2014-03-19" version="1">MPQLRSHHDLLLAAVFSSCLTLPPLTANAQSISTSTPVPPLQWINLTPQLQGSSPPPLKDVSIGYDDTSRNLLIFGGESQTGVPQDGTHLLNLNTLTWATPNPPSGFEGSPDPRSAAIGGLDSAASYRNGHVVIGGRGSSGPLSDVWEYDYNNQFWAKVNVPAGGPARWGAAGGIDLRVGFNTSTPIPNNTFFLAGGVDSSGPVAISDTWKLELTGTLSSNLRNALDATWVQQPIDTSLPAMSGVGGAVISQQVIAVGGCTQTTNVSASCAQQSSYVLNIPKGSSITPATCIAPRVGPAVAPNENRALSNFGSQVFVVLGLFDSSKWNDNGGLQKGEVDVLDMNGGSWARILPAGDPGTDGTVTYPSPREGAAAFSFSIGLVGSSRNSYSDTLVFGGRDASGTYQNELWLLRAYNGSVTSSGQKWSGFSDGKLQTGINANGAGVTRNFFCQALWHDVPDFSLWDIAADTVSSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4KES5</accession>
    <name>W4KES5_HETIT</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_415544</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543546.1">
        <property type="nucleotide sequence ID" value="XM_009545251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KES5"/>
    <dbReference type="FunCoup" id="W4KES5">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KES5"/>
    <dbReference type="GeneID" id="20673256"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_415544"/>
    <dbReference type="eggNOG" id="ENOG502SK6Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_769462_0_0_1"/>
    <dbReference type="InParanoid" id="W4KES5"/>
    <dbReference type="OrthoDB" id="205166at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008501">
        <property type="entry name" value="THOC7/Mft1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05615">
        <property type="entry name" value="THOC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="202"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="92"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW83800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="345" mass="38052" checksum="E39DC4F5606E5381" modified="2014-03-19" version="1">MSSKPSAPSTPQPSAITPLTVEEEDAIIHSRITNDERALRRVIKKFHGYTSVAHEPIVPIPSSSISIEDARDAFLVELASFSLQLKKAVMVCEAEARQVEEYHRERQRIEDERVALRGQIEQLKTSLEHAQLERRRKIEYDLVAEKINTLPSRQELQRTIDSLESDMTAIRVDHDAQNRLIHAQKSALVSIISELGSLRLMGKDTETPRDTTPALDTVGSDGEVPLSIVTAADADTEKEEGEEDRQSSDDVPLSATLNPGPRAFYASRDSVATGSRSLRSRTGLSSAPQSAAVSRAASKSIEDDDIEMGELTEEPKDSRTKVKVRELEEGEASDESSELSDPPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W4KET5</accession>
    <name>W4KET5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_313507</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544024.1">
        <property type="nucleotide sequence ID" value="XM_009545729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KET5"/>
    <dbReference type="FunCoup" id="W4KET5">
        <property type="interactions" value="464"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KET5"/>
    <dbReference type="GeneID" id="20670038"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_313507"/>
    <dbReference type="eggNOG" id="KOG0871">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066247_11_3_1"/>
    <dbReference type="InParanoid" id="W4KET5"/>
    <dbReference type="OrthoDB" id="601405at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22905">
        <property type="entry name" value="HFD_Dr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000019">
        <property type="entry name" value="Negative cofactor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042225">
        <property type="entry name" value="Ncb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138:SF1">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="3">
        <location>
            <begin position="17"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW84343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="146" mass="16418" checksum="A8FC22A09C6F1CBC" modified="2014-03-19" version="1">MSDREGHSGAPTDEDLSLPKATVAKMITELLPDDVTCAKETRDLVIECCVEFIHLISSEANEICEQESKKTIAPEHIIGALRRLGFETFTSEVESVLKDHKQQQKDREKKVSKFVESGLTEAELLAKQEELFAQSRARFQSQQQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KF97</accession>
    <name>W4KF97_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">U3 small nucleolar ribonucleoprotein protein IMP4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_313499</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544071.1">
        <property type="nucleotide sequence ID" value="XM_009545776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KF97"/>
    <dbReference type="FunCoup" id="W4KF97">
        <property type="interactions" value="613"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KF97"/>
    <dbReference type="GeneID" id="20670037"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_313499"/>
    <dbReference type="eggNOG" id="KOG2781">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040063_2_0_1"/>
    <dbReference type="InParanoid" id="W4KF97"/>
    <dbReference type="OrthoDB" id="10253204at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000001">
        <property type="entry name" value="IMP4, U3 small nucleolar ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF2">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="3">
        <location>
            <begin position="91"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00040513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW84394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="322" mass="37440" checksum="88896B9F3517389C" modified="2014-03-19" version="1">MLYSYWFLQKLRRQARERRQYVYAKSLEAQERQTYERKRQLKDALANGKQLPTELRKEAKNLGNDLGFDEAQTDPATHVDSEYSRAGVSDPKIVITTSRDPSSKLLQFAKEMRLVFPNSHRINRGNYVVKELADACRANDVTDLIVLHEHRGTPDAMIVSHFPHGPTLYFTLHNVNLRHDIATYKSSTVSEQYPHLIFENFSSKLGERVRDCLKFLFPVPKEDSKRVMTFSTENDFISFRHHVFLKVPPKQIQLAEVGPRFELKPYEIRQGTIEQTEAEREWVLSHYSRTAKKRSVLSGPYTMPSQSQSDQPGEGTKKRVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFC6</accession>
    <name>W4KFC6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_416118</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544098.1">
        <property type="nucleotide sequence ID" value="XM_009545803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFC6"/>
    <dbReference type="FunCoup" id="W4KFC6">
        <property type="interactions" value="419"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KFC6"/>
    <dbReference type="GeneID" id="20673293"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_416118"/>
    <dbReference type="eggNOG" id="KOG2309">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036235_0_3_1"/>
    <dbReference type="InParanoid" id="W4KFC6"/>
    <dbReference type="OrthoDB" id="10267824at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000020">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000006">
        <property type="entry name" value="60S ribosomal protein L8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023672">
        <property type="entry name" value="Ribosomal_uL2_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007180">
        <property type="entry name" value="PRK09612.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="5">
        <location>
            <begin position="2"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="4">
        <location>
            <begin position="95"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW84424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="254" mass="27415" checksum="28887A7A547F34AC" modified="2014-03-19" version="1">MGRVIRAQRRSHAIFKAHTHLNKNPAQLRALDFAERNGYVRGIVKEIIHDSGRGAPLARVVFRDPYRYKLRKETFIATEGMHTGAFVYCGKKATLAVGNVLPVSACPEGTIICNVEEKVGDRGALARTSGNYATVIGHSPEENKTRIRLPSGAKKTVAGGARATIGIVAGGGRIDKPLLKAGRAFHKYKAKRYNWPRTRGVAMNPVDHPHGGGNHQHIGKASTIARSAVPGQKVGLIAARRTGLLRGSVKVKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFD6</accession>
    <name>W4KFD6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kinesin-like protein unc-104</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HETIRDRAFT_473032</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544108.1">
        <property type="nucleotide sequence ID" value="XM_009545813.1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
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    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
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        <location>
            <begin position="1506"/>
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    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
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        <location>
            <begin position="1470"/>
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    </feature>
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        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
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            <begin position="596"/>
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        <source>
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    <sequence length="1607" mass="179004" checksum="A45D8561E044A839" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFG0</accession>
    <name>W4KFG0_HETIT</name>
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        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_416281</name>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
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    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="118" mass="13587" checksum="2213B3368C4FCF3B" modified="2014-03-19" version="1">MSLICERRHVHYRIVFKELGKSLREIHDLHDAFEALIDALMALKLLHKYKFVHRGIGAGNILLIEKRGVLADLDSAQSLSPNSLLKDPVGTYPFMAMEVSVRSYFFILHKMQSWQIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFP6</accession>
    <name>W4KFP6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 15">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HETIRDRAFT_103204</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 15"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544315.1">
        <property type="nucleotide sequence ID" value="XM_009546020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFP6"/>
    <dbReference type="FunCoup" id="W4KFP6">
        <property type="interactions" value="138"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KFP6"/>
    <dbReference type="GeneID" id="20665875"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_103204"/>
    <dbReference type="eggNOG" id="KOG3359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008438_2_1_1"/>
    <dbReference type="InParanoid" id="W4KFP6"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031502">
        <property type="term" value="C:dolichyl-phosphate-mannose-protein mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23283">
        <property type="entry name" value="beta-trefoil_MIR_PMT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000034">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF50">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="611"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="652"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="676"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="709"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="342"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="412"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="481"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="824"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="824"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="855"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="883"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="900"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="938"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETW84677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="948" mass="106184" checksum="4AB2E5557D728398" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFV1</accession>
    <name>W4KFV1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_313164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009546065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFV1"/>
    <dbReference type="GeneID" id="20670009"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_313164"/>
    <dbReference type="HOGENOM" id="CLU_2558550_0_0_1"/>
    <dbReference type="InParanoid" id="W4KFV1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW84723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="74" mass="7606" checksum="0CFDA3C808752FA3" modified="2014-03-19" version="1">MPSWLSSPPLGAACAALHTGGPARASVGSRCKMLSACRVRSGPTVPRLGKAGWYWSRCLRGRVTAPGGPTLVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4KG15</accession>
    <name>W4KG15_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_314083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009545649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KG15"/>
    <dbReference type="STRING" id="747525.W4KG15"/>
    <dbReference type="GeneID" id="20670088"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_314083"/>
    <dbReference type="eggNOG" id="ENOG502S960">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055001_0_0_1"/>
    <dbReference type="InParanoid" id="W4KG15"/>
    <dbReference type="OrthoDB" id="359154at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="42567" checksum="C2A4A21F9983D4A5" modified="2014-03-19" version="1">MSWSTRQVRTATTALPWTKDFRHLQSFPRHWLKRFSFADQNIKAARVKDRIKYWNIVPGDQVRVRGDESERILEVSRINKLTNRVYLKGMGETSSSRTGVKNVHYSRCQLFIGNHEFPPKGNAKEPRVVPVFATRLGTSQPHWLPTHHRYEWDRFAAATTPRLPAQTHQTDRVRIPWPKVEEPVRAQPTRYDTTAEAVTAITYKPFALPSTLKAPVPELAYEKGYIQSLFNPQARSFDASAPVEVHLHKELSNPHGRAKKQARWQARRAWRQTLLSDYVRAEMKELKGRTRAEARAEGTWKWSQRLVDERADERRRRWKSRGAQTRMERRKVRKERKAVKEGERLKRLVLHEAPNQVIPQPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGU4</accession>
    <name>W4KGU4_HETIT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_233057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541957.1">
        <property type="nucleotide sequence ID" value="XM_009543662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGU4"/>
    <dbReference type="GeneID" id="20668726"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_233057"/>
    <dbReference type="HOGENOM" id="CLU_1731689_0_0_1"/>
    <dbReference type="InParanoid" id="W4KGU4"/>
    <dbReference type="OrthoDB" id="2884925at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="148" mass="17353" checksum="058C73F016981D95" modified="2014-03-19" version="1" fragment="single">EEAQSAPPAADLDLRDVDTGQIVQHPTISDLNFSTASLRAHNESLPISQFPNEMLENIFDFCFDGWEWQPHYRTIEYSYDHRTFPRLYPGWIQLTHICSRWRRVAIGYPRLWSTIAYDSKQWFDLCIKRLPPKQIIDVTLQISGDRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2024-07-24" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHR7</accession>
    <name>W4KHR7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_433472</name>
        <name evidence="1" type="ORF">HETIRDRAFT_439364</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544473.1">
        <property type="nucleotide sequence ID" value="XM_009546178.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544489.1">
        <property type="nucleotide sequence ID" value="XM_009546194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHR7"/>
    <dbReference type="GeneID" id="20674674"/>
    <dbReference type="GeneID" id="20675133"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_433472"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_439364"/>
    <dbReference type="HOGENOM" id="CLU_2210391_0_0_1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW84845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="107" mass="10797" checksum="43F1CFA2EF2D93B0" modified="2014-03-19" version="1">MESVKSARAIIGIRVRGLSEVSSVAAAASKLMEGPTEDASDSELNMVRGGGCRVGGAGQCCSGRVVDGGGRGRGRGRGGALGRAEGAVCMGKVVHRRGARAWQATQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIA9</accession>
    <name>W4KIA9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_100769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542437.1">
        <property type="nucleotide sequence ID" value="XM_009544142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIA9"/>
    <dbReference type="STRING" id="747525.W4KIA9"/>
    <dbReference type="GeneID" id="20665708"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_100769"/>
    <dbReference type="HOGENOM" id="CLU_1343407_0_0_1"/>
    <dbReference type="InParanoid" id="W4KIA9"/>
    <dbReference type="OrthoDB" id="446925at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="204" mass="22987" checksum="72FAEC49195E6E6A" modified="2014-03-19" version="1">MNTTTNINNNIPLPLNYSDIPHTSTAILADDQIVAVRKWHSDLTCPSGLSNAEYTTFLRYCTEFFLASDKLWKKDVQGRHKLITLPTHHISILALAHNDVAHKGFFATCILIIQQTRNVLIPPVVALPATLFAKIYMDTMHMPMAGGFQYLVQGRCSILHYPEFHMLHNKTNAALANWISEDILCCWGTLVKIVSNNRPAFVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIF2</accession>
    <name>W4KIF2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_100862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </feature>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="ETW85484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="127" mass="13999" checksum="8EAB5AE16D7C387C" modified="2014-03-19" version="1">MAENPTAYYNRQNLRSAVHRAAPSPHPQSRNYMEAPPQRSKRFVNPPHADLGATQDECEARRGRRVLDVVRSRERAVEKARAIVASLQLSALSIYQGEPSSIASGFAKTPSTASKKPSQARRRSSAS</sequence>
</entry>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Duplessis S."/>
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                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
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                <person name="Hietala A."/>
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                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
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                <person name="Velez H."/>
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                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">TC 32-1</strain>
        </source>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
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    <accession>W4KJ42</accession>
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        <recommendedName>
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                <person name="Aerts A."/>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Fossdal C.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="58462" checksum="5A88B54F1D3A20C3" modified="2014-03-19" version="1"> </sequence>
</entry>
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    <accession>W4KJD7</accession>
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                <person name="Bouzid O."/>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="Yakovlev I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_380161"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="78" mass="8917" checksum="933CA51A9158F695" modified="2014-03-19" version="1" fragment="single">MGGATFDTIKRPKSEPNSKVFDDAVVDTSRWRHVRECILGRDGRTRSTWARCTVEYKFWSSGKTARFLCTSSGWALQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJI7</accession>
    <name>W4KJI7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GID complex catalytic subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glucose-induced degradation protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_44227</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RMD5/GID2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541808.1">
        <property type="nucleotide sequence ID" value="XM_009543513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJI7"/>
    <dbReference type="FunCoup" id="W4KJI7">
        <property type="interactions" value="353"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KJI7"/>
    <dbReference type="GeneID" id="20675430"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_44227"/>
    <dbReference type="eggNOG" id="KOG2817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020227_4_0_1"/>
    <dbReference type="InParanoid" id="W4KJI7"/>
    <dbReference type="OrthoDB" id="1933281at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16652">
        <property type="entry name" value="dRING_Rmd5p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000143">
        <property type="entry name" value="Regulator of gluconeogenesis Rmd5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037683">
        <property type="entry name" value="Rmd5_dRing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF3">
        <property type="entry name" value="GH10162P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CTLH" evidence="10">
        <location>
            <begin position="148"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="RING-Gid-type" evidence="11">
        <location>
            <begin position="333"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="9">
        <location>
            <begin position="333"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00075398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00080744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW86023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="389" mass="43932" checksum="0983623F9DD0E338" modified="2014-03-19" version="1">MDAAVKELVKLEKLTSTSSSPSKGKSPSIDNSLDFLLETLHDLRQHLMDGVASEEEIRDLCKVVDTRKKEIDDRQKEVYNTLARYGKALDKRFTNPLPTYNPLFASSEAESALEHVIAMHFLRIGRFSTAETFIEEFNVDISTELQAQFIDLHRILVALREQNIDPALEWVRNNRPFLQSRASSLEFYLHRSKYLRLLSASHTPIPTHAIDYANKYLRPFYDSHPGEFQRLLSCIMYLQKLETSPYADLASPTVHCDLEPMFATEFSACLGLSKQVPLKVVGDIGGGGALAKIEKGRKIMRERKSEWSQADELPVSIEIPLPPENRYHSIFACPVSKDQATEQNPPMMMTCGHVISKDSLQKLGKGNGRVKCPYCPVESVTTSALRVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJL2</accession>
    <name>W4KJL2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_247611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542122.1">
        <property type="nucleotide sequence ID" value="XM_009543827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJL2"/>
    <dbReference type="GeneID" id="20669183"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_247611"/>
    <dbReference type="HOGENOM" id="CLU_202883_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJL2"/>
    <dbReference type="OrthoDB" id="2728997at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="71" mass="8125" checksum="5A86206F4D75020A" modified="2014-03-19" version="1" fragment="single">LTNPRNPESKGPAMAKPTPFDGNRKQTEQFLHEINLMILARRHNFLDEFTKIAYALSYMKGGSAGIWSRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJY0</accession>
    <name>W4KJY0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_308660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of a tri-snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNUT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542797.1">
        <property type="nucleotide sequence ID" value="XM_009544502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJY0"/>
    <dbReference type="STRING" id="747525.W4KJY0"/>
    <dbReference type="GeneID" id="20669605"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_308660"/>
    <dbReference type="eggNOG" id="KOG3263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075596_5_0_1"/>
    <dbReference type="InParanoid" id="W4KJY0"/>
    <dbReference type="OrthoDB" id="21368at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013957">
        <property type="entry name" value="SNRNP27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077">
        <property type="entry name" value="U4/U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077:SF1">
        <property type="entry name" value="U4_U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08648">
        <property type="entry name" value="SNRNP27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein" evidence="9">
        <location>
            <begin position="26"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW86009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="88" mass="9793" checksum="67FAD4856087A43F" modified="2014-03-19" version="1">MGISQDTHKIDDAGEEGEEMDIVNEDDSAMMAMMGLSGFGSTKGKQIGGNQEGTADIKKMRTWRQYMNRRGGFNRPLDRVKVSQFMTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKP4</accession>
    <name>W4KKP4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HETIRDRAFT_153488</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540443.1">
        <property type="nucleotide sequence ID" value="XM_009542148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKP4"/>
    <dbReference type="STRING" id="747525.W4KKP4"/>
    <dbReference type="GeneID" id="20667434"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_153488"/>
    <dbReference type="eggNOG" id="KOG0385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_0_2_1"/>
    <dbReference type="InParanoid" id="W4KKP4"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000082">
        <property type="entry name" value="ISWI chromatin remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000005">
        <property type="entry name" value="Photoperiod-independent early flowering 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.30">
        <property type="entry name" value="ISWI, HAND domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015194">
        <property type="entry name" value="ISWI_HAND-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036306">
        <property type="entry name" value="ISWI_HAND-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015195">
        <property type="entry name" value="SLIDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF49">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09110">
        <property type="entry name" value="HAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09111">
        <property type="entry name" value="SLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101224">
        <property type="entry name" value="HAND domain of the nucleosome remodeling ATPase ISWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="202"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="505"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="15">
        <location>
            <begin position="863"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="131"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="812"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1038"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1054"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1067"/>
            <end position="1077"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ETW86418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1089" mass="125544" checksum="6CF3DCA0C3255422" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KL31</accession>
    <name>W4KL31_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_99012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540543.1">
        <property type="nucleotide sequence ID" value="XM_009542248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KL31"/>
    <dbReference type="GeneID" id="20678880"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_99012"/>
    <dbReference type="eggNOG" id="ENOG502T20M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_30_1_1"/>
    <dbReference type="InParanoid" id="W4KL31"/>
    <dbReference type="OrthoDB" id="3049938at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="17016" checksum="694FA608A9D80BFD" modified="2014-03-19" version="1">MSDKGNKPKDFDGTRSKYREWIYECHMYILANPTKYDTDMNKTLMVLSYMREGTASLFAQKYYFDRELREYKAMETKKAWGTFKDFLQELATAFKDKSLEQKVRQKLFTMRMGKQSADEFVTDYLMIAGESGFDLESTINYFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KL51</accession>
    <name>W4KL51_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_99056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540590.1">
        <property type="nucleotide sequence ID" value="XM_009542295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KL51"/>
    <dbReference type="GeneID" id="20678887"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_99056"/>
    <dbReference type="HOGENOM" id="CLU_930838_0_0_1"/>
    <dbReference type="InParanoid" id="W4KL51"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844312" evidence="2">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW86583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="299" mass="32031" checksum="2E31151DEDCA9911" modified="2014-03-19" version="1">MRSWGVCGFVISAASIARAASGTQGRGEVAAGQRLAARVSGDAGLSMSMSLSMSMSSGRAGAGRALRGGHRRLGVDSCAPGPVGGLCEARARHPVVMGVECMKWDPVWRCQSASRGEEEKLGHRKAHSLPDAVAAADRWRESSQGTCEAESARRARTPQHANTSDLCASAVYTRVALTPTCTCTIPNHRPKRRERGGADQQKRRRALRELGTNAPTPALYRAHAARRKENPPAQARQPTRVLHVGIEGEGEGVQKYAQMATMGRCVPPDRYGAVANPKRARSGLRTQAASPRRRKANAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W4KL71</accession>
    <name>W4KL71_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HETIRDRAFT_457491</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the U5 snRNP complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542605.1">
        <property type="nucleotide sequence ID" value="XM_009544310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KL71"/>
    <dbReference type="FunCoup" id="W4KL71">
        <property type="interactions" value="631"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KL71"/>
    <dbReference type="GeneID" id="20676839"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_457491"/>
    <dbReference type="eggNOG" id="KOG0333">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_11_3_1"/>
    <dbReference type="InParanoid" id="W4KL71"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17945">
        <property type="entry name" value="DEADc_DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057479">
        <property type="entry name" value="PRP28/DDX23-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25430">
        <property type="entry name" value="DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="355"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="386"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="612"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="46"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="278"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="355"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="46"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETW85781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="751" mass="82867" checksum="485C8BF885EE0181" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLA8</accession>
    <name>W4KLA8_HETIT</name>
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        <recommendedName>
            <fullName evidence="5">Phosphoglycerate mutase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_308843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009544620.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="W4KLA8">
        <property type="interactions" value="299"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KLA8"/>
    <dbReference type="GeneID" id="20669623"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_308843"/>
    <dbReference type="eggNOG" id="KOG0235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_9_2_1"/>
    <dbReference type="InParanoid" id="W4KLA8"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043456">
        <property type="term" value="P:regulation of pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051695">
        <property type="entry name" value="Phosphoglycerate_Mutase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517:SF1">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW86145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="21820" checksum="25ADF42DF476D140" modified="2014-03-19" version="1">MPLVRVYIVRHGETEENRNSIIQGHLDTRLNADGLEQARRVGKALQAVPFDLAFSSDLTRAAKLQTTRELRERFLGELQGLTYSARQKAAGQSSVEPAEKMTARALGWWDETIVKHAAAAGGDSALNVLTVSHGGLIGHLVRGLVETKRAVVAKGVFIGKCMNTAVAIVEVGRVGPGVVVQYGDITHLLAEGDMDLVQANADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLI6</accession>
    <name>W4KLI6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_306078</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540572.1">
        <property type="nucleotide sequence ID" value="XM_009542277.1"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KLI6"/>
    <dbReference type="GeneID" id="20669375"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_306078"/>
    <dbReference type="eggNOG" id="KOG1863">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002870_0_0_1"/>
    <dbReference type="InParanoid" id="W4KLI6"/>
    <dbReference type="OrthoDB" id="2420415at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025305">
        <property type="entry name" value="UCH_repeat_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13446">
        <property type="entry name" value="RPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="839"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="185"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="268"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="943"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="944"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="954"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="976"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="994"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1036"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1056"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW86564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1430" mass="155626" checksum="24A9554D94567C32" modified="2014-03-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4KM07</accession>
    <name>W4KM07_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_99271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540819.1">
        <property type="nucleotide sequence ID" value="XM_009542524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KM07"/>
    <dbReference type="GeneID" id="20678899"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_99271"/>
    <dbReference type="HOGENOM" id="CLU_2158746_0_0_1"/>
    <dbReference type="InParanoid" id="W4KM07"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="111" mass="12024" checksum="B1ABE12133BA6577" modified="2014-03-19" version="1">MSFAASPFLCTDRLRFSVEVHTPSWASVLAGSMHGALGPPFPLASFPARSSATKIPRHLQALDGFLYATDLYLADSTPMAHKPRTMCGRMISSLDSSMEISASGEVPYFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4KM61</accession>
    <name>W4KM61_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">3-ketoacyl-CoA thiolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_468663</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540891.1">
        <property type="nucleotide sequence ID" value="XM_009542596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KM61"/>
    <dbReference type="STRING" id="747525.W4KM61"/>
    <dbReference type="GeneID" id="20677246"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_468663"/>
    <dbReference type="eggNOG" id="KOG1389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_1_1_1"/>
    <dbReference type="InParanoid" id="W4KM61"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF10">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="8">
        <location>
            <begin position="31"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="9">
        <location>
            <begin position="295"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW86928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="44027" checksum="58D5C2CE90306B2D" modified="2014-03-19" version="1">MAMERVKQLASHLISPSGGRAVLERKNPDDIVITLAIRSPLCKAKSGGLKDTRSDELLTEMFKQAISHSKIDPSVIGDITVGTVLPRAPMYEARSAALAAGIPQSVPVQTVNRFCSSGLMAVTSIANQIRAGQISVGLAVGVDSMTFNPDQGPDPASSEISCHATAADALKPMGWTSENVAGDYSISREDMDAFAAASFQRAERAQNSGWFESEIVPFHAFKKDPKTGEREAVVVSRDDGIRAGTKKEALLKIRSAFPQWAPSQTTGGNASQNSDGAAAVLLMTRRKAEELGQPILGKYVTTSVAGLAPRVMGIGPTYAIPMVLEATGLTKEDVDIFEINEAFASMLVYCVRTLDLDHEKVNVNGGAIALGHPLGCTGARQVVTGLNELKRRGGKVLVTSMCIGTGMGAAAVFIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KM81</accession>
    <name>W4KM81_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_305576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540778.1">
        <property type="nucleotide sequence ID" value="XM_009542483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KM81"/>
    <dbReference type="GeneID" id="20669338"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_305576"/>
    <dbReference type="eggNOG" id="ENOG502SSEC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142954_0_0_1"/>
    <dbReference type="InParanoid" id="W4KM81"/>
    <dbReference type="OrthoDB" id="3201641at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="15153" checksum="692ADC47E40A93E9" modified="2014-03-19" version="1">MLVLSNVHKLLARALAPPELHTAVLLTPAGQLVSCAADPARCKDDVRAIVGLSGEKWQEAGDRGVGMESPFGRIMVLAGVGAGEVASEKPLMLVALNATSAVEWDVLEAKAKLAGHLARPIGKIRAPLAAAMAVPAAPATTPSRLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMG2</accession>
    <name>W4KMG2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_305990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540853.1">
        <property type="nucleotide sequence ID" value="XM_009542558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMG2"/>
    <dbReference type="FunCoup" id="W4KMG2">
        <property type="interactions" value="641"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KMG2"/>
    <dbReference type="GeneID" id="20669364"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_305990"/>
    <dbReference type="eggNOG" id="KOG2318">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010564_0_1_1"/>
    <dbReference type="InParanoid" id="W4KMG2"/>
    <dbReference type="OrthoDB" id="431825at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039754">
        <property type="entry name" value="Esf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056750">
        <property type="entry name" value="RRM_ESF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202:SF0">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25121">
        <property type="entry name" value="RRM_ESF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ESF1 RRM" evidence="7">
        <location>
            <begin position="169"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="6">
        <location>
            <begin position="607"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="390"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="634"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="405"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="425"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="463"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="499"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="530"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="559"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="577"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW86884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="694" mass="78177" checksum="64D5E1C7CBEDAF1D" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KN26</accession>
    <name>W4KN26_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4939 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_98969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009542172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KN26"/>
    <dbReference type="GeneID" id="20678876"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_98969"/>
    <dbReference type="HOGENOM" id="CLU_1384325_0_0_1"/>
    <dbReference type="InParanoid" id="W4KN26"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="22983" checksum="13C7306412E19B31" modified="2014-03-19" version="1">MSGQASTSTDPPSMTVQPRRGKVKFPDNYPDNRIESQKFMLQCLLLFAAESDRYKTNQDKISLVLSCMRYGTAGAWVENFLLKLVGADPPTDLEAFAQFEETRRDTWVRQGEETARLIWKEKTTHPLWETKREYIEEWRWRMLITTTSGYHNLVLRWNIHTLPHPDDPKRTISNASCRLTDDREMEASVILLESEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNB2</accession>
    <name>W4KNB2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_114043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="GeneID" id="20666440"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_114043"/>
    <dbReference type="HOGENOM" id="CLU_963308_0_0_1"/>
    <dbReference type="InParanoid" id="W4KNB2"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="289" mass="31894" checksum="875E345D75E47D50" modified="2014-03-19" version="1">MSEEVKMAVVEVELEKAVEIVNLVVKVIFGLRSIGGMWWSSGESIRAMRGAGDVDECEIEDEDGDDPPINASTGFKIWVPNADEIHFGRSKGAKETVEFKLGLGESQFMVAKGDGAESGIVLNPQIVERTLTEVEADHDFQSVEGLVIWVALTGDPNDTNHPQKCPNIGEIPARSPLHNRFYPRLVGQPSFIRAAVADNYDFGCAECCLVPRKCSSAVLHPLNHLIEALKVFPHKPSYAGVVGMRLEASIRKFVSGRWALNRNIINERNGGVWDLWLEDVGDVVVEDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNJ4</accession>
    <name>W4KNJ4_HETIT</name>
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        <recommendedName>
            <fullName evidence="15">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_431284</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540629.1">
        <property type="nucleotide sequence ID" value="XM_009542334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNJ4"/>
    <dbReference type="STRING" id="747525.W4KNJ4"/>
    <dbReference type="GeneID" id="20674522"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_431284"/>
    <dbReference type="eggNOG" id="KOG1729">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3524">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005251_0_0_1"/>
    <dbReference type="InParanoid" id="W4KNJ4"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF270">
        <property type="entry name" value="FYVE-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DH" evidence="11">
        <location>
            <begin position="111"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="371"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="12">
        <location>
            <begin position="607"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="56"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="424"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="728"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="883"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
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            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
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            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="813"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW86626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="935" mass="103079" checksum="4AC3D834ED8E837A" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPU6</accession>
    <name>W4JPU6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_164897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="59" mass="6598" checksum="ADA5086E4B91878E" modified="2014-03-19" version="1">MTNIVCSSLLFQSMSAITAHLHRSFWSCIALRSFLMLCSKHLRTSSQQAYQRAGSMATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQQ7</accession>
    <name>W4JQQ7_HETIT</name>
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        <submittedName>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="20674911"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_436822"/>
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    <dbReference type="InParanoid" id="W4JQQ7"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="246"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="287" mass="30808" checksum="74F257A0446D481D" modified="2014-03-19" version="1">MVSPHPPPPNQPTFSYADRARNVLKSHNPPSQRPSIVSEHAAASNMPHSSTSTSDASKPSSLIPSTGIASNPSISPTRTVPFPASPTSPVEGLVVCGTNGDVTSTIPTKTAPINVWNLRMEQMAQARASSRPVQLRSQNNMLSSARDLPDDPSVKLPNPNSIATQNGLPSLRIDGNTDPFATRALSQALAADIPRAPALVNDMENWPEVGQSVGSSSKGTTQHRHDASESTEEQRREDDESSTSLPILPKKSASLVIFTTPLSTFRTIHSISFYTIYFHLLPATRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
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    <name>W4JQW3_HETIT</name>
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        <submittedName>
            <fullName evidence="12">GMC oxidoreductase 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">gor12</name>
        <name evidence="12" type="ORF">HETIRDRAFT_148913</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GMC oxidoreductase family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="20667306"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_148913"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002865_6_0_1"/>
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    <dbReference type="OrthoDB" id="269227at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="11">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="543"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="586"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="101"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW75271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="608" mass="65765" checksum="AD804687308B694B" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JR17</accession>
    <name>W4JR17_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_422602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552218.1">
        <property type="nucleotide sequence ID" value="XM_009553923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JR17"/>
    <dbReference type="GeneID" id="20673825"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_422602"/>
    <dbReference type="HOGENOM" id="CLU_1133708_0_0_1"/>
    <dbReference type="InParanoid" id="W4JR17"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="245" mass="26478" checksum="A839FB881A313AD4" modified="2014-03-19" version="1">MVHFAMQQQAVEAQALEEEAEQVATAEHEAEEAEVARAASALEVAEKDHQREMFSELLDVKKGNHQMAALKAESILPLSLFLHSPSPSVPAMSFSCPKPSFAHLPSQPNPLVAESNLASTTTTLHCISIDPVTLVTLTNMNGKPLAAAVVVEFAHQQTPSFGCVMLPLGPGYGQMSTVWASEEWNGASKVLKNPPGLVFGDCLSMLVQFLDHGVLLLHLAWLGVLYQVCQLAKGVQFPAWVDTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4JR40</accession>
    <name>W4JR40_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell morphogenesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_329435</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552165.1">
        <property type="nucleotide sequence ID" value="XM_009553870.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="W4JR40">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JR40"/>
    <dbReference type="GeneID" id="20671493"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_329435"/>
    <dbReference type="eggNOG" id="KOG1825">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000325_1_1_1"/>
    <dbReference type="InParanoid" id="W4JR40"/>
    <dbReference type="OrthoDB" id="6287725at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025614">
        <property type="entry name" value="Cell_morpho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025481">
        <property type="entry name" value="Cell_Morphogen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029473">
        <property type="entry name" value="MOR2-PAG1_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14225">
        <property type="entry name" value="MOR2-PAG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14228">
        <property type="entry name" value="MOR2-PAG1_mid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14222">
        <property type="entry name" value="MOR2-PAG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell morphogenesis protein N-terminal" evidence="2">
        <location>
            <begin position="376"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1496"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1755"/>
            <end position="1938"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis protein C-terminal" evidence="3">
        <location>
            <begin position="1968"/>
            <end position="2217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW75929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2417" mass="270912" checksum="AF707CBE8C547FB8" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JR85</accession>
    <name>W4JR85_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_455649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552276.1">
        <property type="nucleotide sequence ID" value="XM_009553981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JR85"/>
    <dbReference type="GeneID" id="20676646"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_455649"/>
    <dbReference type="HOGENOM" id="CLU_2223613_0_0_1"/>
    <dbReference type="InParanoid" id="W4JR85"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="106" mass="11785" checksum="BD5218A5952B79A2" modified="2014-03-19" version="1">MLMKRSCRSVIFRYAIKVLAVDVDEEARTSQGTNTRLPANCQWAAMTDGESRQAFVIQRSPHISKRWSGLCSAPFYDCVRDALVPKPLGGACLGRRVLSGAERWPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRA6</accession>
    <name>W4JRA6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">B-related factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_330876</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552822.1">
        <property type="nucleotide sequence ID" value="XM_009554527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRA6"/>
    <dbReference type="FunCoup" id="W4JRA6">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JRA6"/>
    <dbReference type="GeneID" id="20671620"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_330876"/>
    <dbReference type="eggNOG" id="KOG1598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010293_2_3_1"/>
    <dbReference type="InParanoid" id="W4JRA6"/>
    <dbReference type="OrthoDB" id="511529at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
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            <end position="321"/>
        </location>
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        <location>
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            <end position="437"/>
        </location>
    </feature>
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            <begin position="489"/>
            <end position="530"/>
        </location>
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            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
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            <end position="437"/>
        </location>
    </feature>
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            <begin position="490"/>
            <end position="500"/>
        </location>
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            <end position="512"/>
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            <end position="530"/>
        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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</entry>
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    <accession>W4JS45</accession>
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        </lineage>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
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                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
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                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="461"/>
        </location>
    </feature>
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        <location>
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            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW75925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="622" mass="68343" checksum="E1A11F711B92CF42" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSH5</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">HETIRDRAFT_389544</name>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009553115.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSH5"/>
    <dbReference type="GeneID" id="20672416"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_389544"/>
    <dbReference type="HOGENOM" id="CLU_2758091_0_0_1"/>
    <dbReference type="InParanoid" id="W4JSH5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="70" mass="7659" checksum="0615D442A9105418" modified="2014-03-19" version="1" fragment="single">MGGLLAGELGFHSALYRGAFSLLFWARLFEFFTGALLPTYLATGLSVCRRRLQSVAAAIVIHVLFTPTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSN4</accession>
    <name>W4JSN4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CPL1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_446505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551443.1">
        <property type="nucleotide sequence ID" value="XM_009553148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSN4"/>
    <dbReference type="STRING" id="747525.W4JSN4"/>
    <dbReference type="GeneID" id="20675690"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_446505"/>
    <dbReference type="eggNOG" id="ENOG502SS21">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063728_0_0_1"/>
    <dbReference type="InParanoid" id="W4JSN4"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048661">
        <property type="entry name" value="CPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038955">
        <property type="entry name" value="PriA/CPL1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21671">
        <property type="entry name" value="CPL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844969" description="Protein CPL1-like domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Protein CPL1-like" evidence="2">
        <location>
            <begin position="201"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW76553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="299" mass="31504" checksum="22F20F600E712AA6" modified="2014-03-19" version="1">MMRLYRLLPAALLLLSRPGTAAAQLHRNDLRDLVDVCASLDVDLAIPLGSKPLVVGKLDLCLCISAIPEFLQTNLIAIAAVAIAGKPVVTGVLTGLINDAAGKSRCTYPEHSVPACTGKSCGFSCTDGFSPSPASHPTTCVCKAPNTVCNGVCGHFPSCASGKPHTKRSKKDRLWEGSGTCWDRGQGWMACGVFGGAARAWECVNTKKDLESCGGCMLPLTPYTPTGTDCTALPGVADVECISGSCVVQRCAKGYVPSWDGTECIHTPSSPQHHAVYAEWDEDDTPATRYGLEHVPLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSY0</accession>
    <name>W4JSY0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase/Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_156749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551453.1">
        <property type="nucleotide sequence ID" value="XM_009553158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSY0"/>
    <dbReference type="STRING" id="747525.W4JSY0"/>
    <dbReference type="GeneID" id="20667663"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_156749"/>
    <dbReference type="eggNOG" id="KOG4178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_7_0_1"/>
    <dbReference type="InParanoid" id="W4JSY0"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="29"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="327" mass="36715" checksum="B691A4E0771F7244" modified="2014-03-19" version="1">MDVASYKKYITTRGFTYNYYFSAAQPEKPTLVFMHGFPSSSWDWTSQATFFKARGYGLIIPDMLGYAGTDKPTDPKAYVGSGLARDIVDIMDNESVQKAIAVGHDWGARPTSRLANYHPDRFIAFGFLAVCYAPPNPVHNPAAQAAAIRQLVGRDIFAYWDFFTEEGADKKIEQNFDSFFSLFFPSPPELWRENVTTIGATKAWIEGNKQSPAPAYVRPEFKEHYRKTLLEGGLAGPLCWYRVNTEGLAAEDDKQAPLSSYEIHHPVFFGAALKDEICLPMFGKAVLQRLAKGPVTIREFDGDHWFMVSHAEELNGELLAWLEGLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTF4</accession>
    <name>W4JTF4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_446565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551618.1">
        <property type="nucleotide sequence ID" value="XM_009553323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTF4"/>
    <dbReference type="GeneID" id="20675694"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_446565"/>
    <dbReference type="HOGENOM" id="CLU_043968_0_0_1"/>
    <dbReference type="InParanoid" id="W4JTF4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="487" mass="54578" checksum="D832D0CE608D9EF7" modified="2014-03-19" version="1">MFPPSSTSSRYRPSTPERSPDPKPYEDRERKYSAWWSGSRRAEDWQGLTEDKVGETPQPLCQTETSPQTRISAMATPETLIACFQPVSPLTMYRWMPKLDHIEPQVKIIVDALTALSISKRGDVAAVALETHAQSTCTIYIAASDKDNSLESHFQILWDCLRRVALSTGGASPSLDSPAIDVGVEVYNFVWTAFYDRFSKNAESFVTDFISQVTDPMFGAKISEKERRDLQTAENLFDTLRKIVTPTNPANADMKKIVATLGLLNATLKPYLDFLPPNALVRRCCDSLENVSTTFVWLYLDDVLDLQPPIEVLLDTARSAITRSWFTQSLRVIQVPNAHLPFEVDMHDAVLRLWKDHKGIENPDADLDAQWNSHIIDPILDMVDSSKWENVSIVSTGGRVILSASVRPHSVCALVVHLANSADASPFSYIGLSFNHPCYACYMFLSAYNQSNSRVPFYTLGPKSGFSSLSFSLHSPTTTSWWRMIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTH1</accession>
    <name>W4JTH1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_328365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551632.1">
        <property type="nucleotide sequence ID" value="XM_009553337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTH1"/>
    <dbReference type="STRING" id="747525.W4JTH1"/>
    <dbReference type="GeneID" id="20671412"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_328365"/>
    <dbReference type="eggNOG" id="ENOG502QRZN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054792_0_0_1"/>
    <dbReference type="InParanoid" id="W4JTH1"/>
    <dbReference type="OrthoDB" id="445341at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF5">
        <property type="entry name" value="ISOCHORISMATASE FAMILY PROTEIN FAMILY (AFU_ORTHOLOGUE AFUA_3G14500)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="1">
        <location>
            <begin position="105"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="295" mass="32987" checksum="2AA495EC3128D741" modified="2014-03-19" version="1">MSKDQQTSSGDIGKIGEGDTSLVLDILPEDLCAIAFENLRKEVQWHTMLHRGGEVPRLVAVEGAVDIDGSFPIYRHPTDFTPPLEPFSSTVSLIRQHVEKALNHPVNHVLIQHYRTGADYISEHSDKTVDVVRGSNIVNVSLGAQRTMFLRTKKEKDPAAATPRITQRIPLPHNSMFVMGLDTNNKWMHSIHTDKRPMKTKSPAEQFQGGERISLTFRHIGTFLTKGEKKIWGQGAKSKTKNEARPVVNGGEEAEKLLAAFGRENHESTFVWDDHYGQGFDVLHFTKHPGGEVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTL8</accession>
    <name>W4JTL8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_436959</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552441.1">
        <property type="nucleotide sequence ID" value="XM_009554146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTL8"/>
    <dbReference type="STRING" id="747525.W4JTL8"/>
    <dbReference type="GeneID" id="20674924"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_436959"/>
    <dbReference type="eggNOG" id="KOG2582">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028825_2_1_1"/>
    <dbReference type="InParanoid" id="W4JTL8"/>
    <dbReference type="OrthoDB" id="29061at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055089">
        <property type="entry name" value="COP9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF1">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22788">
        <property type="entry name" value="COP9_hel_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="COP9 signalosome complex subunit 3 N-terminal helical repeats" evidence="9">
        <location>
            <begin position="13"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="253"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW76236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="429" mass="44430" checksum="9668B167DAAC6122" modified="2014-03-19" version="1">MPDGSDPLDAIDLDGPAGSLIVLFILSARLTHGGPAASDAPPAAPLFPTSHIGEFCARFDPAQARLAPERVSLLAKGIYQRADARGSLQTAIAPLRDLVMRYPPSPAHLTTVHPLFLSACLSTTHPAPALPLLTNHPITHAPRALAPDLAHADVTSYHLLAGAALAALKRFAEAAEYLEMCAAAPVAGAEPSVVQVDAMKKLVLVQLILHGKTTPPPKYTHPAIANVRGTPYGALARAYPDAGALRDVVRRERALFDADGNAGLVAQALGRAPRWAIRRLTETYMTLGLAEIARAAQLGDADAARRVVLGMIESGEIDARIAADGTVRFEDPTAATHAAAVDRAALEGVLRAAQAQERVLRALERETARGREYLGKATKGREHAVGEYVIEEELVGGAGGGGGGAGGAGAGAGAGAGAGVAQWVDESVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JU67</accession>
    <name>W4JU67_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_411450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550561.1">
        <property type="nucleotide sequence ID" value="XM_009552266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JU67"/>
    <dbReference type="GeneID" id="20672952"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_411450"/>
    <dbReference type="HOGENOM" id="CLU_3106632_0_0_1"/>
    <dbReference type="InParanoid" id="W4JU67"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW77004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="51" mass="5319" checksum="3F90E44CE4FE6D21" modified="2014-03-19" version="1" fragment="single">MATTGNDHACHGANVIGVCLSGPRYSRWTEIGTNLGDRCIACTTPSASVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUN4</accession>
    <name>W4JUN4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_429503</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550729.1">
        <property type="nucleotide sequence ID" value="XM_009552434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUN4"/>
    <dbReference type="FunCoup" id="W4JUN4">
        <property type="interactions" value="606"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JUN4"/>
    <dbReference type="GeneID" id="20674354"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_429503"/>
    <dbReference type="eggNOG" id="KOG0299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014017_2_0_1"/>
    <dbReference type="InParanoid" id="W4JUN4"/>
    <dbReference type="OrthoDB" id="189968at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000899">
        <property type="entry name" value="Chromosome 15, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039241">
        <property type="entry name" value="Rrp9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="160"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="229"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="271"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="313"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW77189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="576" mass="62880" checksum="03B3A634F29A9FBA" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUP0</accession>
    <name>W4JUP0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_52669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550506.1">
        <property type="nucleotide sequence ID" value="XM_009552211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUP0"/>
    <dbReference type="GeneID" id="20678222"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_52669"/>
    <dbReference type="HOGENOM" id="CLU_094659_1_0_1"/>
    <dbReference type="InParanoid" id="W4JUP0"/>
    <dbReference type="OrthoDB" id="10255174at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW77199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="135" mass="15016" checksum="CA02164EF46BB7CB" modified="2014-03-19" version="1" fragment="single">ENLEGCVNDAKAIESLLVERMQVSDSHIALLTNELATRKAIISRFLTHLVENPRIEHGDPILLFYAGRGSRAVPPSTWMFMSNTVDTICPYDEWLEDPEGGFIAGIPDRTINALLRKLARVKGNNITVILDCCHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUY3</accession>
    <name>W4JUY3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA replication licensing factor MCM4</fullName>
            <ecNumber evidence="11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_156569</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="11"/>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550861.1">
        <property type="nucleotide sequence ID" value="XM_009552566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUY3"/>
    <dbReference type="FunCoup" id="W4JUY3">
        <property type="interactions" value="584"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JUY3"/>
    <dbReference type="GeneID" id="20667648"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_156569"/>
    <dbReference type="eggNOG" id="KOG0478">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_7_1_1"/>
    <dbReference type="InParanoid" id="W4JUY3"/>
    <dbReference type="OrthoDB" id="10251574at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17755">
        <property type="entry name" value="MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
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    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MCM"/>
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    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
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    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF21128">
        <property type="entry name" value="WHD_MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="493"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="442"/>
            <end position="471"/>
        </location>
    </feature>
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        <location>
            <begin position="89"/>
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        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="RuleBase" id="RU004070"/>
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        <source>
            <dbReference type="RuleBase" id="RU368062"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50051"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW77342.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="913" mass="100390" checksum="546136549B65CA8A" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUZ9</accession>
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        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
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    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_454697</name>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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            <taxon>Basidiomycota</taxon>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="233" mass="25923" checksum="86D9D84049E644D8" modified="2014-03-19" version="1">MASIDTPSDRERPRTELDAELLINHPALYFDDGDVILQCGKTLFRVHRSILLKHSTLFQEMLAPARDTLRDSSRARTRTTLRASQPHTEDLIVHPAAVIALLRSINYADNALLSALFYDLNRRTQQLGGAYGHHLASLSEADIGRLMSCHALVSGFWHSPAGQRCLLNMQDLISQPVENWELVKGQVQGTLALPGLSLTGLCSTCRAEMVKYVGQQQATLWGSLSRHFDLAEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4JW73</accession>
    <name>W4JW73_HETIT</name>
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        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_429476</name>
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    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Bondarzewiaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550684.1">
        <property type="nucleotide sequence ID" value="XM_009552389.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_429476"/>
    <dbReference type="eggNOG" id="ENOG502RW2M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048769_0_0_1"/>
    <dbReference type="InParanoid" id="W4JW73"/>
    <dbReference type="OrthoDB" id="3049938at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00343">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW77141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="383" mass="43538" checksum="84CD0678E07378FC" modified="2014-03-19" version="1">MSDRGNKPKDFDGTRSKYREWIYECHMYILANPTKYDTDKDKTLMVLSYMREGTASLFAQKYYFDRELREYKPTETRKAWGTFKDFLKELAAAFKDESLKQKARQKLFTMRMGKRSADEFVTDYLMTAGESGFDLESTVDYFRRAIHPEILKQIYRLPDMPTTMDDWVKYTRRFDNQWRELQSIKSSVPSATVRSSNPFRYNSSNAPSSMNNSVVPMAVDSVRTTLTDEERNRLRMEGGCFYCHQKGHMANQCPVRGSSRLYEGSARYVQQSSGTMGNRSAQTGGRMGGGGSGYGRAFSAGTSGSAQGGAATQGRGVATTNPFQARLAARQAHAPGPDAPVRETEHEISREEVQRVIGKMRWDEQEALLQELSEMSKKKESDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWE9</accession>
    <name>W4JWE9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_55591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009551353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWE9"/>
    <dbReference type="GeneID" id="20678337"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_55591"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_22_0_1"/>
    <dbReference type="InParanoid" id="W4JWE9"/>
    <dbReference type="OrthoDB" id="446925at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="211" mass="23467" checksum="003A2DD628852354" modified="2014-03-19" version="1">MGCSPYFAATGTHPLLPLDIAEATYLLPPPPTTLSTTDLITRRAIALQKRRSDLAHLRSSVVGARVQAAIRFEQQHSATLRDFNFHRDSLVLMRNTAIEKALNRKMRPRYLGPLLVISRNRGGAYILAELDGLVFDRPVAAFRIIPYFAHRSLKLSDLEALLDISQARLRAMEESRSNDDDAEDDDADEEDTDTSSIRSAEDDDVASATSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWK1</accession>
    <name>W4JWK1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Replication factor A protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_411186</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549957.1">
        <property type="nucleotide sequence ID" value="XM_009551662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWK1"/>
    <dbReference type="FunCoup" id="W4JWK1">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="GeneID" id="20672928"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_411186"/>
    <dbReference type="eggNOG" id="ENOG502SBIR">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141922_1_1_1"/>
    <dbReference type="InParanoid" id="W4JWK1"/>
    <dbReference type="OrthoDB" id="188186at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04479">
        <property type="entry name" value="RPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013970">
        <property type="entry name" value="Rfa2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114:SF1">
        <property type="entry name" value="REPLICATION PROTEIN A 14 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114">
        <property type="entry name" value="REPLICATION PROTEIN A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08661">
        <property type="entry name" value="Rep_fac-A_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW77943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="11868" checksum="675A5323D0A67E6B" modified="2014-03-19" version="1">MAEHTTTRVNAHHLPNFIGRRVLIVGKILKFQDDVAIMQACDDLQIEIRLPPTGSNLTDTFVEVVGSVVDASTVKMLACTNMGSSLDTKLVKDVVDLTHDPKFAGRMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4JX08</accession>
    <name>W4JX08_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_411217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
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            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="245" mass="27284" checksum="15ADFDA06A7D918D" modified="2014-03-19" version="1">MAVMFAQLSSNLPPYKRQRRTATSVLAGQFDPRPPRDVLTSLLNGVPINKELEETDEAKREKRREKKERDKEKKRAKALLKPRESPVLPVVESVATPTPMHVNVHPILPLPEPSTSWGARPVLHIASMQRSVSVTPPPMPSSPPTTPGPSISSSTSRTSSKRPHTPYEDEDMDHSRDMSFTTPPPEPRPRKKRAAARKGWKGWVEGSPPPSEKLINLDAVTVLHERRTRSGKNFDAIGLGQDGWV</sequence>
</entry>
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    </protein>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
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                <person name="Rouze P."/>
                <person name="Salamov A."/>
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                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="526" mass="58755" checksum="EA952CA266CF577A" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYB6</accession>
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        </submittedName>
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            <taxon>Bondarzewiaceae</taxon>
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            <taxon>Heterobasidion annosum species complex</taxon>
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    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009552119.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_454382"/>
    <dbReference type="HOGENOM" id="CLU_2590063_0_0_1"/>
    <dbReference type="InParanoid" id="W4JYB6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="80" mass="8397" checksum="BDCD2E583B5D56CD" modified="2014-03-19" version="1">MSRASAIHERTNEPTHNPFTAALHSHAAGASPEASPGSRRTEESCAIPPGRILSRAAQSTVGDDNDKGKPPPSPFPSARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYN4</accession>
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            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009551690.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="W4JYN4">
        <property type="interactions" value="27"/>
    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_460318"/>
    <dbReference type="eggNOG" id="KOG1399">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006909_5_1_1"/>
    <dbReference type="InParanoid" id="W4JYN4"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW77976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="54877" checksum="DBB11D12F3983566" modified="2014-03-19" version="1">MAEHPPNPLVGPHAETPTAEKRICIIGAGAGGLATLKVLKETEQAQSGLWKLTAFEERQAIGGVWLPAPPEQNPPLTPLYDVLTTNLPHLIMGYPSFPFPPSTPLFPSAAIVLKYLQDYAAHFDLLRHVRPNTRVEEARWNASEQVWKVTLSTGELSDFDFIVVANGHYRKPRYPNTQGLQKWIASGRAIHSAWFRRASDHAQYKKVLVAGGGPSGLDISTEMRTVSQLVLHSVPSDAFPSDFAPPPNTDSYRKVPKVKEYKDNGDVVFADGTIESNVEFAILGTGYEVSFPFLPQSTLGVPNFPPPLPSHLYNSTYHIFPLAKHLFPLQSDFPAHTIAFPALPQRVAPFPISEDQARAIARVLTEPSALDVAAEAVAIVERARALAKEEGTDDPLQLAKAWSRFGPREPFEYRAELHAFAKPGTEWRAPDWEVEFWDRKDALRAEWKEVVKSGQAGEWVKGVGERGVQEWVDLCRRLLKRRDDREKQQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYR6</accession>
    <name>W4JYR6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_410641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548928.1">
        <property type="nucleotide sequence ID" value="XM_009550633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYR6"/>
    <dbReference type="GeneID" id="20672887"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_410641"/>
    <dbReference type="HOGENOM" id="CLU_2512908_0_0_1"/>
    <dbReference type="InParanoid" id="W4JYR6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="85" mass="9696" checksum="8E5BDCD0E4C273CB" modified="2014-03-19" version="1">MIFIGSVRGLKRRRTIEKGSSRSDATVGSLVRVLYRWLTCPPLMSTDVGLWARHVLWSRFNFASAAHMMDDVIVEAKSNCRKRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZ85</accession>
    <name>W4JZ85_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_460407</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550181.1">
        <property type="nucleotide sequence ID" value="XM_009551886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZ85"/>
    <dbReference type="FunCoup" id="W4JZ85">
        <property type="interactions" value="465"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JZ85"/>
    <dbReference type="GeneID" id="20677070"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_460407"/>
    <dbReference type="eggNOG" id="KOG0787">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023861_5_1_1"/>
    <dbReference type="InParanoid" id="W4JZ85"/>
    <dbReference type="OrthoDB" id="241648at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="308"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW78186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="442" mass="50096" checksum="26D57EF44777F97D" modified="2014-03-19" version="1">MSAGFRITPALWDRIHHFASFPQTGVSLQQMVLFGQNPSQGTLFKASQFLVEELPVRLAHRVKELDELPHNLSSMPSIKKVKNWYAQSFEELIHFPTISVSRDIRAALMASPTEDTYLPESTPNPSLGDFGDHFAPHSSGNMGANGNGNGSRVKLRIPMEKRYYAKTGNINWPPEVHDYNKRFTKTLDAIKRRHDPTVTTTAQGVLEWKRRQNARNIGLDIQAWLDRFYLSRIGIRFLIGQHVALNELQPHPDYVGIICTRSNVHDIVHEAIENARFVCEEHYAMFKGPPVQLICPKDLHFAYVPGHLSHICFELLKNSLRAVVERYGHDREDQLPPIKVIVVEGKEDITIKISDEGGGIPRSAIPLIWTYMYTTMESQGIDQDFQASDFKAPMAGFGYGLPLSRLYARYFGGDLRLISMDGFGTDVYIHLNRLSSSREPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZU7</accession>
    <name>W4JZU7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_420185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549282.1">
        <property type="nucleotide sequence ID" value="XM_009550987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZU7"/>
    <dbReference type="STRING" id="747525.W4JZU7"/>
    <dbReference type="GeneID" id="20673635"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_420185"/>
    <dbReference type="eggNOG" id="ENOG502S9VY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031133_0_0_1"/>
    <dbReference type="InParanoid" id="W4JZU7"/>
    <dbReference type="OrthoDB" id="4230923at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="408"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="427"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="516"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="553"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="576"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="609"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW79004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="626" mass="70058" checksum="D5109EF27FB2156E" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4K001</accession>
    <name>W4K001_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_410926</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549409.1">
        <property type="nucleotide sequence ID" value="XM_009551114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K001"/>
    <dbReference type="STRING" id="747525.W4K001"/>
    <dbReference type="GeneID" id="20672908"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_410926"/>
    <dbReference type="eggNOG" id="KOG1199">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_42_0_1"/>
    <dbReference type="InParanoid" id="W4K001"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW79148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="258" mass="27157" checksum="5D97DA3F8FDDAA0C" modified="2014-03-19" version="1">MKIENRTFIVSGGSSGLGLATVQTLLDAGARVAILDLRPAEGLSGDARVKFFETDITSAEDIARAVEGTVAWAQTMGARLGGVVNCAGVGTAAKVLDIHGEPHSLDLWNFAIGVNLTGTFNLTRLTCKHLAQTEPEGPDGERGVIIMVASSAAFEGQPGQAAYSASKGALVSMTLPLARDLARHGIRVVTLAPGAFASAMTDKMPLKTRASLERELTFPRRFGSAEEFAGTVKWVVECPYVNGETIRLSGASRLPGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4K089</accession>
    <name>W4K089_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_50705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548788.1">
        <property type="nucleotide sequence ID" value="XM_009550493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K089"/>
    <dbReference type="STRING" id="747525.W4K089"/>
    <dbReference type="GeneID" id="20678153"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_50705"/>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009665_6_1_1"/>
    <dbReference type="InParanoid" id="W4K089"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="148"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW78521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="255" mass="28995" checksum="4FE485C3C4A271DB" modified="2014-03-19" version="1" fragment="single">ATCDILIGADSIKSMVRMFMLQEQAGRAEQHGELAEAADLRNPVQPRWSGVITNKTTGECHRRNTTDGRDHETVTQYGTLVDEHELRFLQHIVAYPISHRKFINFAAFDTDHTKEDSFYGESWIRVSNSREIVDLFRDWEPEVKQLCIRSRKVNRWTMNVVRTLPSYASGRVAILGDAARAMTSIQAAGVGQAIEDAWIRSALLSHPLTTLNSVVQVLQIYSRIRLPLASQVAEGSRRNSMYFCTEGVRRRYLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0B9</accession>
    <name>W4K0B9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Eukaryotic aspartyl protease asp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">asp1</name>
        <name evidence="6" type="ORF">HETIRDRAFT_172810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549488.1">
        <property type="nucleotide sequence ID" value="XM_009551193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0B9"/>
    <dbReference type="FunCoup" id="W4K0B9">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="GeneID" id="20668407"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_172810"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_1_4_1"/>
    <dbReference type="InParanoid" id="W4K0B9"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000008">
        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF57">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845084" evidence="4">
        <location>
            <begin position="19"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="104"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="135"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW79237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="415" mass="43048" checksum="2B04B4E05219FE40" modified="2014-03-19" version="1">MFFPTAFVLAAMPFLVAATPLVASPSTGVAIPIAKRSTFHAADGSINATALSGRVRHSVAKIQKGFTTYEKNTGSPHPLAAGLSKKAKRATGKDALTDDDAELWYGTISVGTPAKTYTVDFDTGSSDLFLPGPSCTTNCAGHTKYTPSSSSTSVDLKKTFSLGYGDGSTVSGEQYTDTVSIAGLTATKQTLGAAKTYSTGFSSDNFPADGLLGMAFKSLSDYKANPLFQSLAAQGKTSSSVFSFKLASSGSELYLGGKNSNLYTGSITYTPVTDASYWQVDMDGLAVDGTSVLSTTAVIIDTGTTQIVGDPDNVATVYDQISGAVSAPQYGDGIYTIPCSFNTPITLTFSGQDFTVDPSTFNLGPVSSGSSTCVGGLASDSKITNKFWIVGDVFLQNVYTIFDVANTQVGFAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0P0</accession>
    <name>W4K0P0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative terpene cyclase</fullName>
            <ecNumber evidence="3">2.5.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cyc1</name>
        <name evidence="3" type="ORF">HETIRDRAFT_181194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the trichodiene synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.21" evidence="3"/>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549012.1">
        <property type="nucleotide sequence ID" value="XM_009550717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0P0"/>
    <dbReference type="GeneID" id="20668589"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_181194"/>
    <dbReference type="eggNOG" id="ENOG502SQ3X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052212_0_2_1"/>
    <dbReference type="InParanoid" id="W4K0P0"/>
    <dbReference type="OrthoDB" id="2998174at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016838">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on phosphates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024652">
        <property type="entry name" value="Trichodiene_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06330">
        <property type="entry name" value="TRI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW78696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="313" mass="35729" checksum="352B522C7AC0A75C" modified="2014-03-19" version="1">MAVTEPFDAHNVPSVSAGDLSSRLAPVFRSFLTDMTYTPPAAPSTNEQLKVVMQAEMDARGTRCVELERLAHLAINYVECVFPHYNFEEKTAIALYHWYLLYVDELAPINAAPLIAFKGRLLRHQPQLDPVLDALPAVFARFYDLYEPFTADFIYSSALEFITGTALEPQTKHLPLIRKADRFPLYLRELCGIGEGYAHMIFPKRLGVSIVEYIEAVPDMIIWINLSNDLLSFYKEELGGETATYVHLRAAVEKKDHMQVLAEIKDELIIAQETIRATLATSSAALQAWKSFEQRLIFWHMTQDRYRLKELNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4K223</accession>
    <name>W4K223_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="8">2.7.7.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_321424</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="8"/>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548403.1">
        <property type="nucleotide sequence ID" value="XM_009550108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K223"/>
    <dbReference type="STRING" id="747525.W4K223"/>
    <dbReference type="GeneID" id="20670748"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_321424"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037448_0_0_1"/>
    <dbReference type="InParanoid" id="W4K223"/>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="10">
        <location>
            <begin position="252"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW79863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="416" mass="45213" checksum="ABD1C998EC46A29A" modified="2014-03-19" version="1">MESTEPNAHHKKTLHSKRSFGKYPHKIDSPAYDASEEDNDPLTDDAASALSIPAPSRNHSANTSQPRASSAAASQSNAVPSAAKSRLKHYLASSAVLSDDGVDSPTYDGDIESSTTAGPDRENSKAASAVAVSHIRSSSTSTLTSPVSVFHALPDDASGSPFHAGPTIVTAFAPSTASSSDVEPVTVTVTRRHAINTTPSEPEPVAAAQEAFDPAALAADDIQSFVRQAIDGELHRKYKINEPPVGRPVRVYADGVYDLFHFGHALQLRQAKLSFPDVYLLVGVCSDELVKEHKFSCVMSHAERCEAARHCRWVDEVVPEAPWVIDAEFVERYQIDYVAHDEDPYVSAGHEDVYDFVKRLGRFIPTRRTPGVSTSSLLERIVKGYRKRDFDKKLENMGHAELMAQGSDYEEKGTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2E9</accession>
    <name>W4K2E9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elicitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_247865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548523.1">
        <property type="nucleotide sequence ID" value="XM_009550228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2E9"/>
    <dbReference type="GeneID" id="20669208"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_247865"/>
    <dbReference type="HOGENOM" id="CLU_160407_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2E9"/>
    <dbReference type="OrthoDB" id="2536450at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34862">
        <property type="entry name" value="SPARK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34862:SF1">
        <property type="entry name" value="SPARK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="10365" checksum="10B729C33333960D" modified="2014-03-19" version="1" fragment="single">SLSSQCQSTFLSVAASPEASCLNLAGLIPFFSIDHNASLVAPINTWSTDFCSQSACTNQSLATVFETLIPDCSEGFDSSQTNYTVESAIATIQSIYPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2G3</accession>
    <name>W4K2G3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_322648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548450.1">
        <property type="nucleotide sequence ID" value="XM_009550155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2G3"/>
    <dbReference type="GeneID" id="20670892"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_322648"/>
    <dbReference type="HOGENOM" id="CLU_2498131_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2G3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="86" mass="9216" checksum="900AAF0090A4229F" modified="2014-03-19" version="1">MPGLSGCVSKPPFGSSYRVGGPQIGTSSMKGMVVSGISGWRMWVTSSWKIGTKFVHPMGRVTSRWAPNGVWNVVKSRDDSASPRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4K315</accession>
    <name>W4K315_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_171744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548297.1">
        <property type="nucleotide sequence ID" value="XM_009550002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K315"/>
    <dbReference type="GeneID" id="20668360"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_171744"/>
    <dbReference type="HOGENOM" id="CLU_2812682_0_0_1"/>
    <dbReference type="InParanoid" id="W4K315"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="67" mass="7273" checksum="BE409D8CFFC8EC90" modified="2014-03-19" version="1">MITSLSAPARRTPALTHPCEGRPSAGFIELSPSDDADGVSRARMRKACSPERDHGSRNRDEPPRSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4K337</accession>
    <name>W4K337_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">chorismate mutase</fullName>
            <ecNumber evidence="1">5.4.99.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_428410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.99.5" evidence="1"/>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548666.1">
        <property type="nucleotide sequence ID" value="XM_009550371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K337"/>
    <dbReference type="STRING" id="747525.W4K337"/>
    <dbReference type="GeneID" id="20674270"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_428410"/>
    <dbReference type="eggNOG" id="ENOG502RC50">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_538676_0_0_1"/>
    <dbReference type="InParanoid" id="W4K337"/>
    <dbReference type="OrthoDB" id="191918at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.590.10">
        <property type="entry name" value="Chorismate mutase, AroQ class superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037039">
        <property type="entry name" value="CM_AroQ_sf_eucaryotic"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW80149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="506" mass="56477" checksum="E4B0C6231B5F38FD" modified="2014-03-19" version="1">MPSNESTHLSSENTLIEQTPSTDPSIPSTPEMSIVEERSVPWDTDEEQAAREAEEGFSEYLEGLDEDEQRQDEMIRLLTEDFDRPSPSHSPSPPPLIHTPSEGIVFPDRETYLTTPVAYMMGLIEGTPNTEFVSGPTRPEIQRALEILEEERSFVRHTQRALQIREGTLIARINAGERKLIGLDQTTPLRDTFHPTDDITPVTEYHMPTTAVVSRASSSASNRAPLRPMPGAYPMERGRGRDVYSPRMVGNEVGYHDVRTQGLSRHDSTVGSENDLSPDYTSRSCSTDTCILIENISLYTIKSFLRQNSRFLGSDNILLAILIISNYQILLGPGLGCRLKDFWQMSTIVEYLGRVFDGLKIRIAKILLKTGDIEVKVLIFVRVGSSYCTDPAIYADGDKRLLEFINARENASAASGRFDYGKLEYPFALSPIAPDSATKNDTLPPGRFHQDSFNGNANLISFYVGTLVPDFFQAPTSFFFHLDNSTLNDDAAMNLEAILLALLSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3G1</accession>
    <name>W4K3G1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_410366</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548184.1">
        <property type="nucleotide sequence ID" value="XM_009549889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3G1"/>
    <dbReference type="GeneID" id="20672857"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_410366"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_2_1"/>
    <dbReference type="InParanoid" id="W4K3G1"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF2">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="30"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW79616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="384" mass="42538" checksum="485585CC646529CB" modified="2014-03-19" version="1">MSFFAPPPPPATGLGRYRVLSPLAGIRVSPLQLGAMSIGDKWKGMGAMNKESSFKLLDAYYEKGGNFIDTANSYQDETSEEFIGEWMEARGIRDQLVIATKYTSNFKRGDPSVAQKVNYVGNSTKSLHISLAASLRKLRTSYVDVLYVHWWDWGTSVEETMRALHRVVLSGQVLYLGASDMPAWVVAKANQYARDHAMTPFSIYQGRWNVMMRSFEREIIPMAREEGLALAPWDVLAAGKIRTDAEEAVRRETGENGRVIFGPDWERTPDERKVCAALEVVAGQVGVTSIQAVAIAYLMHKTTHVFPIVGGRKVEHLEANITALDIALSPEQIAYLEAALPFDVGFPASMIGTGLEDPPLLKSAAHMDRWPLRQPILPVKKSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4K3Q5</accession>
    <name>W4K3Q5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_459276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547194.1">
        <property type="nucleotide sequence ID" value="XM_009548899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K3Q5"/>
    <dbReference type="STRING" id="747525.W4K3Q5"/>
    <dbReference type="GeneID" id="20676983"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_459276"/>
    <dbReference type="eggNOG" id="ENOG502S8WT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041941_0_0_1"/>
    <dbReference type="InParanoid" id="W4K3Q5"/>
    <dbReference type="OrthoDB" id="10256743at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="470" mass="51510" checksum="848B58E85992F327" modified="2014-03-19" version="1">MSTVSEATSRPVEPVAPTTGAPIDPVPLSFPAVLRNPGLNSRFAHLHRGGDSEGRPAPAPVSNPTRREDREGKRWIRRKENARFVGNPHIAAPTKRDYAPVRPTTHPTFPVPLPPYLPRNVALPHAVPPPISPDTANAGRFSLSTRGMRRTLRKAGPRTQALVKAVENEIVGWLSEGGVVLQPDGTLTAGFEGLQFPGRAIGEQQGVREVERSPLKLVWWIEDDAWARYVVHCCARYYEVVSFSKDTSTHRLTHLLRPNVTRPDHAARAALMTPPATDLDLSSLSSYDSDILSSFSDILSDATHSDALSESENGGGPLSDIASDHEPLSDIASDAGAEADVERERAEERPHSPASVGSIYRDGMQDADVWSVDGDSELDRAIVALSVQDSPVSSVFPESMNQEETPRPRHGATYRRRVWDRNTRSASSPSRSPARRGPRRRMDTHILTSTARTGKAAGKGERSFYEYLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4K471</accession>
    <name>W4K471_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_476313</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547362.1">
        <property type="nucleotide sequence ID" value="XM_009549067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K471"/>
    <dbReference type="GeneID" id="20677673"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_476313"/>
    <dbReference type="eggNOG" id="ENOG502QUA0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020178_2_1_1"/>
    <dbReference type="InParanoid" id="W4K471"/>
    <dbReference type="OrthoDB" id="2140105at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053001">
        <property type="entry name" value="MNNG_permease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814:SF1">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="3">
        <location>
            <begin position="87"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW80638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="483" mass="53809" checksum="5A5778252E24DD73" modified="2014-03-19" version="1">MSTNHSVQKRASNSDSISGMTISNSGIPMANVSNRTKTLSDDTGASSAPVVHDDDDKVWFSENFFSKEPSTSRARALYLKIVFGTSFMITVFIMTVLPIYWGALWKVPSHVHNLKGWIVDFDGAQMGQFVTQAFISSSGLPTRMTWEVVSPDRFPNGQADIIDLLVHEHTWAIVAINPGATNSFNSSIASTNGSYNGSSAVTIYTEEARSENAYNQIIKPNVEIVMKNASSIFAASSTNQLALGGRNLSNIAINAPQLLSAPLYYTVYNTRPFDVPVAAAVDFVGLIYLLIVAFVTSLVNTVARTDVTHIEDRLRFRSLMLARAIVPILIYFYLSCFFSMISLAFQAPFNRTFGHSGFVIYWMLSWIAMCALGLAVEAMVTLITVRFIPFFLILWIIGRLLLIPNVSVCFMPISVLPRVYRYGYAMPFYNVQRAVRTIVFNTKNDLGLNFGVLIAWSLISLMTMTLFQYMARRRAIKQHVESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4D1</accession>
    <name>W4K4D1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GET1</name>
        <name evidence="9" type="ORF">HETIRDRAFT_418651</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the WRB/GET1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547387.1">
        <property type="nucleotide sequence ID" value="XM_009549092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4D1"/>
    <dbReference type="FunCoup" id="W4K4D1">
        <property type="interactions" value="216"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K4D1"/>
    <dbReference type="GeneID" id="20673496"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_418651"/>
    <dbReference type="eggNOG" id="KOG4253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089418_0_1_1"/>
    <dbReference type="InParanoid" id="W4K4D1"/>
    <dbReference type="OrthoDB" id="69461at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03113">
        <property type="entry name" value="Get1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028945">
        <property type="entry name" value="Get1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027538">
        <property type="entry name" value="Get1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650:SF1">
        <property type="entry name" value="GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650">
        <property type="entry name" value="TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04420">
        <property type="entry name" value="CHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="3"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="169"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW80667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="204" mass="22628" checksum="8EFCE2FD56E7A409" modified="2014-03-19" version="1">MSLILTIFALVFITELVSWVGQSVLLSFAWAAYQRIFNPSAVARQRQLKADILAKKAELLQTSAQDQFARWAKLRRSVDKGLAELEKLNGDLNSSKSAFAVKFNSVVWILTTGLQFVVGWWYRKSAVFYLPPTWMGPVTWWLSFPFAPAGSVSCGVWQMACRRVVKIGERAAVEFVGFSAEPVSTDAATGMGGAEPASKDQKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4P4</accession>
    <name>W4K4P4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Ornithine aminotransferase</fullName>
            <ecNumber evidence="4 9">2.6.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HETIRDRAFT_477620</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2-oxocarboxylate + L-ornithine = L-glutamate 5-semialdehyde + an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:13877"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="EC" id="2.6.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="4 9"/>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548555.1">
        <property type="nucleotide sequence ID" value="XM_009550260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4P4"/>
    <dbReference type="FunCoup" id="W4K4P4">
        <property type="interactions" value="350"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K4P4"/>
    <dbReference type="GeneID" id="20677761"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_477620"/>
    <dbReference type="eggNOG" id="KOG1402">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_3_1"/>
    <dbReference type="InParanoid" id="W4K4P4"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019544">
        <property type="term" value="P:L-arginine catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010121">
        <property type="term" value="P:L-arginine catabolic process to proline via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000011">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000152">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW80031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="472" mass="50643" checksum="25AE81F3FA96E752" modified="2014-03-19" version="1">MAPSAFADNGAQGAPANPNGKASGKSGSGGSVHLSSADVIQLEHQFGAHNYHPLPVVFDRALGAKVWDPEGNEYIDMLSAYSAVNQGHCHPRIVATLVEQAQKLTLSSRAFYNSVFGRFAQKVTTLFGYDMVLPMNTGAEAVETAVKLSRKWGYEKKGIRDGKAVVLSVEGNFHGRTLGVISMSTDPESRGGFGPYLQGVGPTFQDGAQTRTIRYGVIEDLERALELYGTDVAAFLIEPIQGEAGIVVPPEGYLSKVRALCTKHNVLFICDEIQTGLCRTGKLLCCEYDNVRPDIILLGKALSGGVYPVSAVLADRDVMLCIKPGEHGSTYGGNPLGCAVAMTALDVLLEEQLAERAAALGEKFRALVRAIKSPLIKTVRGRGLLNAVVIDETQSAKGRSAWQLCLLLKSKGLLAKPTHVNIIRFAPPLVIEEADIVKAVKIIEEALSDLDKLDDIPGEVQSEKGFKDEISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4X1</accession>
    <name>W4K4X1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_418427</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547172.1">
        <property type="nucleotide sequence ID" value="XM_009548877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4X1"/>
    <dbReference type="STRING" id="747525.W4K4X1"/>
    <dbReference type="GeneID" id="20673480"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_418427"/>
    <dbReference type="eggNOG" id="ENOG502S6WI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091449_2_0_1"/>
    <dbReference type="InParanoid" id="W4K4X1"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF52">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="61"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW80415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="250" mass="27336" checksum="ED2571351A6908C4" modified="2014-03-19" version="1">MHTVVYRGCARANLNLLYASTSYASSTTTTHRRRPVSTSSSSSTSSSSANPYPYPTASHPSPHQIFHLPPSASQAEIKARYYQLVRVYHPDAPTARLIPPDVAQARFHAISRAYDVLRGRSPSGALDDGSGLGVGLGQRVRDFHDLSSAMRRRARRRGAEMNVPMDDRWKDRLFLGSLLVAVGVFVMQTSMARRSSIGEALDRGAFEAAVIRARVGESSDRTRTGEGTMRRSRGDDDALDAEAGVRSGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>W4K506</accession>
    <name>W4K506_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_321369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547520.1">
        <property type="nucleotide sequence ID" value="XM_009549225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K506"/>
    <dbReference type="GeneID" id="20670744"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_321369"/>
    <dbReference type="HOGENOM" id="CLU_2373055_0_0_1"/>
    <dbReference type="InParanoid" id="W4K506"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW80819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="95" mass="10743" checksum="898DA49E4085B961" modified="2014-03-19" version="1">MARQPYLEHSKTLERRFICTVRLATLDERHLSFRTLCAMLSSSCHKFGICWDWSFVNYGKQCDLLIAFAVASSSRRLAGPAFLAVPSSSGPLFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4K662</accession>
    <name>W4K662_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_474727</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545976.1">
        <property type="nucleotide sequence ID" value="XM_009547681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K662"/>
    <dbReference type="FunCoup" id="W4K662">
        <property type="interactions" value="74"/>
    </dbReference>
    <dbReference type="GeneID" id="20677582"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_474727"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="W4K662"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF85">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G00710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="8"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW81307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="464" mass="51281" checksum="9E264F91090DD2D1" modified="2014-03-19" version="1">MTKIDLMIIPLVGVIYFLSFLDRANIGNARLAGLQKDLNMTNHQFSVSLTVFYVPYILMEIPVNLVLKRFGANITIPLMVVLWGLFSACQGAVSTYGGLIACRFFLGMAEGGLFPSLVLYLSNFYPRHSLQLRLSMMFSVTSLAGAFSGLLAAAIEDMNGLRGLAGWAWIFVLEGVFTVLCGILGFFLLPREPSKLRWLTRHEKAVYVEMLREDWSGDAEDEKFSWAEVWNVFLDAPHVLILCMHFFIEGITLFGLATFTPTIVNALGFSMTHSQLLTVPPFACSFVVSLVSAYLSDKYKRRGVTALVFSFLAIVGYAIFIGTLLAASSHANYGALFLQIIGVYGLAPCTATWNANNVQPHFRRATAIAFAFACTNMGGIVSTWIFIDPPRFHTASAVNVSFAIGNVIACGGLIVYLVRRNASKRVQVAILLREKGNGTEKGGWDSPEERQRLGDRHPRFVYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6X5</accession>
    <name>W4K6X5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_28304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546888.1">
        <property type="nucleotide sequence ID" value="XM_009548593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6X5"/>
    <dbReference type="STRING" id="747525.W4K6X5"/>
    <dbReference type="GeneID" id="20669286"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_28304"/>
    <dbReference type="eggNOG" id="ENOG502SY12">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146165_0_0_1"/>
    <dbReference type="InParanoid" id="W4K6X5"/>
    <dbReference type="OrthoDB" id="3267074at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="11059" checksum="2EBA5F1398C7D399" modified="2014-03-19" version="1" fragment="single">LMQLRTGHAPLQRHLHRIRPDEFENPTCPACGQRDETVAHFLLECRSFTDSRHRLEQAVGRASRNLSELLSNPSMFKHLFEFIHETQRFKKTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6Y8</accession>
    <name>W4K6Y8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Midasin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_444807</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the midasin family.</text>
    </comment>
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        <property type="protein sequence ID" value="ETW81514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009547858.1"/>
    </dbReference>
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        <property type="interactions" value="376"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K6Y8"/>
    <dbReference type="GeneID" id="20675597"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_444807"/>
    <dbReference type="eggNOG" id="KOG1808">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000050_0_2_1"/>
    <dbReference type="InParanoid" id="W4K6Y8"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005654">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:preribosome, large subunit precursor"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
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    </dbReference>
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        <property type="entry name" value="AAA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Midasin_AAA_lid_5"/>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
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        <property type="entry name" value="VWF_A"/>
    </dbReference>
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        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="8"/>
    </dbReference>
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        <property type="entry name" value="AAA_lid_5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA_lid_7"/>
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    </dbReference>
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        <property type="entry name" value="MDN1_4th"/>
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    </dbReference>
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        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="12">
        <location>
            <begin position="4894"/>
            <end position="5121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="851"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="4244"/>
            <end position="4750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="854"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1555"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4291"/>
            <end position="4308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
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            <begin position="4309"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
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            <end position="4420"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
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            <end position="4437"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
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        </location>
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        <location>
            <begin position="4557"/>
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        </location>
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        <location>
            <begin position="4570"/>
            <end position="4584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
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        </location>
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        </location>
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        <location>
            <begin position="4685"/>
            <end position="4694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR010340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW81514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="5124" mass="570923" checksum="4E92316B1BBF8C71" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4K749</accession>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="van Diepen L.T."/>
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                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Lucas S."/>
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                <person name="Yakovlev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW80871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="122" mass="13972" checksum="0C1FD542A0EF0CCD" modified="2014-03-19" version="1" fragment="single">MNDRIITPIRLNVKVSNRSQNAGAKATIDSACEGVIVNETWVKRHRFPTYTLNNPIRVRNVDDTINKAGLIRSALDVNLTIRDICGRTHTERVQMFISNLGKDDLILGTDWLKYHDPSIEWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7K0</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
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                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
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                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545984.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7K0"/>
    <dbReference type="GeneID" id="20674145"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_426780"/>
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    <dbReference type="InParanoid" id="W4K7K0"/>
    <dbReference type="OrthoDB" id="3258143at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="383" mass="42539" checksum="969A0D37864D47F1" modified="2014-03-19" version="1">MSTLSKAQHEGVHWILSAFRTSPIGGMEVLAGIPPLHLHIKKLVQRAALCTLRLLNQHPINTALHLQHPHEHSPHIPFPLHCTRASSNLPIQLIRDLIPKNTKSFAPLHPEVQPGKRVIDTFADHITFRLLHPPKSSPEFPAWVRDLKRRIAAESSSNNTTTCFSDGSFSPYNGRHAGCACLVLPPNSDPPIIRKLAYGQTTAFNAEVMGLTIALHHAILTPNTFNIILYADNEAALKSLLDPRVHPSQMCSILACQRLRAWLSATLNRHLTIAWCPGHVGIPRQEQKAYTSMLAAWQTLMQSTKYSGRDFPRQRAFQKVASTKSKVLRQVGQHNTLAARTVRLILNHGPMVPRDTNMQAHTILVHSLPAPAGLHGHKILILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7P1</accession>
    <name>W4K7P1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_409582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546399.1">
        <property type="nucleotide sequence ID" value="XM_009548104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7P1"/>
    <dbReference type="GeneID" id="20672782"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_409582"/>
    <dbReference type="HOGENOM" id="CLU_2758082_0_0_1"/>
    <dbReference type="InParanoid" id="W4K7P1"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="70" mass="7465" checksum="06721F8F5527A2EA" modified="2014-03-19" version="1">MRSYAGAVWRGTRSSIYICRPTAFDHSQTADLEEASAARESSPPAPVLALSRTVHAASGGKYAACRGRHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7P5</accession>
    <name>W4K7P5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_118186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546404.1">
        <property type="nucleotide sequence ID" value="XM_009548109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7P5"/>
    <dbReference type="GeneID" id="20666578"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_118186"/>
    <dbReference type="HOGENOM" id="CLU_359044_0_0_1"/>
    <dbReference type="InParanoid" id="W4K7P5"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="642"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="780" mass="85626" checksum="D0F0B462F4392A58" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7Q4</accession>
    <name>W4K7Q4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_440110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546451.1">
        <property type="nucleotide sequence ID" value="XM_009548156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7Q4"/>
    <dbReference type="GeneID" id="20675229"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_440110"/>
    <dbReference type="HOGENOM" id="CLU_1073863_0_0_1"/>
    <dbReference type="InParanoid" id="W4K7Q4"/>
    <dbReference type="OrthoDB" id="2322499at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="259" mass="29062" checksum="BE83C3332CF4CB6D" modified="2014-03-19" version="1">MMHWFKQRRTRFIKMLPPDFQSLQISDSVVRISTPAAAARRTDGKVGFAGALQLAVAVFTDGALAYIGRDFCNVWKMRTTDFLVTKDFLFSQRGFDAAANLVALVGRASTTTTAADMDRLDLRFVCDDCGGATESERRASKSQAEYAFGWRKCVDHYMLSNRIDHSTPSFSVLPPDITADVKSREPEDPSLMHQRWQCNHCSALPELEDRATVAEHILTVHNITAPADDEDLFYLPSPGTRRPLIAYQPVEPFDVALER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7W7</accession>
    <name>W4K7W7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_444958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546474.1">
        <property type="nucleotide sequence ID" value="XM_009548179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7W7"/>
    <dbReference type="GeneID" id="20675605"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_444958"/>
    <dbReference type="HOGENOM" id="CLU_044614_9_3_1"/>
    <dbReference type="InParanoid" id="W4K7W7"/>
    <dbReference type="OrthoDB" id="3259206at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="359" mass="40170" checksum="109FE66DD62DD916" modified="2014-03-19" version="1">MSAFNSMYIDAQTNNASDLTEAQAIHDAGLIILYNVTALALQTLFYGIYVVLILFSTWVLCQRGLPRANLMMLVTILVMFISSTSGFWVHTVTVLKRIRSLLVEQPGEPIAAKLPLIRDSLRGMEGGAFYCSLINFILGDSIVVWRAMVLQRHKWQRFVLLCLFLCSIVVAGVVGGSQLRYLISPSDPLGQIIVISRCVYWGLSLVINLLCTCLIACTTWNYRKATQLIGRPMPSRAQQILTLLVESAALYSFLWLALIVGEYIRIPGLSSLVTDMFMPTYTHIAGIYPTAIIVLVKMNRSPCGSDVSIKTMPHMQYASRDRSAQTDAIHRPPSRSIIFSDNDDLEHNKYQTEAVWKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4K854</accession>
    <name>W4K854_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_451089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545920.1">
        <property type="nucleotide sequence ID" value="XM_009547625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K854"/>
    <dbReference type="GeneID" id="20676112"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_451089"/>
    <dbReference type="HOGENOM" id="CLU_667411_0_0_1"/>
    <dbReference type="InParanoid" id="W4K854"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="412" mass="43317" checksum="1F20F34A5BA71E91" modified="2014-03-19" version="1">MAYPSTLPAPSSRLLNLTHLRPALPSDSLPRPTLSTRSLAVLSSPLSSHDLMPTGRLARTVHIPSRILDTTHHPGTSSASYTFVNTSASDATSAVTTIATHITTTTTIAAAASSTSSRRSSESSRTRPSASRHDRDRTPQDRSKSMSAVSTAHIRAALLDQAAAAASASASSRTGWPSLPPVPRPPPPLAAAFRVRISLAGRIKDGLACPTLPPTSATSPAFAPTLSKLILPLRPDSASMQESGSSPSHDPSSTDSPLPSLPHSGDDGLQPDGHDSELITLLCALTLERGMRKPALMEDASHECTRRERGGVVCEDLDGRVIDDADEVEGPTRRGGYVRGPELSHLGLGAFCGGRACTSRGQSPTALDSERFQLWDNVNARPPLGTRAPLEAGLEEVAFTPSAREGRLNDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8C2</accession>
    <name>W4K8C2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_168964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546653.1">
        <property type="nucleotide sequence ID" value="XM_009548358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8C2"/>
    <dbReference type="GeneID" id="20668193"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_168964"/>
    <dbReference type="HOGENOM" id="CLU_2886070_0_0_1"/>
    <dbReference type="InParanoid" id="W4K8C2"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="63" mass="7097" checksum="1D010B893CC6E2C7" modified="2014-03-19" version="1">MRLVITLPKLISCHSKNTKPRPAQVPRNFHTSINPHMSAALLSFLGVYILPEAERLTMANWAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4K928</accession>
    <name>W4K928_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar proton pump subunit B</fullName>
            <shortName evidence="5">V-ATPase subunit B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar proton pump subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_156280</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546222.1">
        <property type="nucleotide sequence ID" value="XM_009547927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K928"/>
    <dbReference type="FunCoup" id="W4K928">
        <property type="interactions" value="141"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K928"/>
    <dbReference type="GeneID" id="20667632"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_156280"/>
    <dbReference type="eggNOG" id="KOG1351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022916_3_0_1"/>
    <dbReference type="InParanoid" id="W4K928"/>
    <dbReference type="OrthoDB" id="1735853at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
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        <property type="term" value="P:vacuolar acidification"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="V-type proton ATPase subunit B, brain"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
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        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005723">
        <property type="entry name" value="ATPase_V1-cplx_bsu"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
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        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="V-ATPase_V1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-synt_ab_N"/>
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    </dbReference>
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        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="35"/>
            <end position="101"/>
        </location>
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        <location>
            <begin position="158"/>
            <end position="385"/>
        </location>
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    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="9">
        <location>
            <begin position="391"/>
            <end position="490"/>
        </location>
    </feature>
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        <location>
            <begin position="492"/>
            <end position="519"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW81591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="519" mass="57539" checksum="73EA2FCAEE7B9E77" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9A9</accession>
    <name>W4K9A9_HETIT</name>
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        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_61178</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="20678539"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_61178"/>
    <dbReference type="eggNOG" id="ENOG502SF44">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="122"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW82314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="322" mass="36335" checksum="01383039538218FD" modified="2014-03-19" version="1">MACIGCTSNLIEFTDGVTWVQQVLHEGLLLALVNISPSFRLLDGDVCTLVLAMLSDRLPRYFVYRSVIVAASAAMTKLDNQHLAKIARSPLKEPWLKLKHLTEERMSIKTEWSVMRKQVGYCDNQGAKDTFKQCARCQTTMYCSKSCQVLGWKKGHKTECELKSLERTADTINRQDRVFMHHLAIRNARDNIVNLREIAARDHPGVPYAGLGVSCDYLKVPPTFGVFALENYTLERLADPTAERTLEARGLSLIAKVRASEGKYTLVESRVSRGETSTLIITISVRSLWEFDSDWEEEMNRLIDLSAEDVGMPSAWAKELTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9N2</accession>
    <name>W4K9N2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_318718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546636.1">
        <property type="nucleotide sequence ID" value="XM_009548341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9N2"/>
    <dbReference type="STRING" id="747525.W4K9N2"/>
    <dbReference type="GeneID" id="20670530"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_318718"/>
    <dbReference type="HOGENOM" id="CLU_2855882_0_0_1"/>
    <dbReference type="InParanoid" id="W4K9N2"/>
    <dbReference type="OrthoDB" id="2501483at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="65" mass="7978" checksum="E97A9B62CC720B2F" modified="2014-03-19" version="1" fragment="single">WFNSSIADLMNMWFRGFYSIIYKMHKDHYNFFLDEMIRQQNSIIINSLYFCGVICYKIPYSYLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9N3</accession>
    <name>W4K9N3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_105063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
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</entry>
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                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545695.1">
        <property type="nucleotide sequence ID" value="XM_009547400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KC48"/>
    <dbReference type="GeneID" id="20667332"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_149241"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_1_0_1"/>
    <dbReference type="InParanoid" id="W4KC48"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844208" evidence="4">
        <location>
            <begin position="19"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="69"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="100"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW83447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="394" mass="41310" checksum="5F3C2A4D43DAE167" modified="2014-03-19" version="1">MFPTLALGLLAVSAGVEAIANPVHSPAKINLSSRRIRNPPRPSVSSQRRALSPANLPLTDFFKGTDLQWYGNISVGTPSQQITVVFDTGSSTLEFASKQCGSACSNQVQFDTSKSSTYKDGGRTSSISFATGVGVDPVQSDDDYTLTLRSGSDVVSVGGLDAGRVSLFTITDQTPKFNIDPFSGIQGMSSQAQGFFAALIKKGLPSLFSLYLTPQKAGNAELTIGGIDNSKFKGDLTYATLSSSDGDWELSSSGISVNGKTTSALKTARDIIFDSGTSNILFDTTTTEAIYALISPDIVANDDEPGTYGIACSKIASLPAKIDIQFTSTAGKAFNLTIPSSELSVGPFASDPSTCQTLINAMDGLDLVGGSVLKHYYSVWDIGGQRMGFASNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCM2</accession>
    <name>W4KCM2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_450545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545120.1">
        <property type="nucleotide sequence ID" value="XM_009546825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCM2"/>
    <dbReference type="GeneID" id="20676058"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_450545"/>
    <dbReference type="HOGENOM" id="CLU_2073458_0_0_1"/>
    <dbReference type="InParanoid" id="W4KCM2"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="118" mass="12329" checksum="35BF5621466DFA2A" modified="2014-03-19" version="1">MSSVFPLLSVSSSSSLLSPPLLSLSLSLVSSSPVPYQTQRSPALYTPRALRCASPLPVSPSPSVTPRLVSPPSSAPPRGARPCTNLTYLPTGSPQYRAHALLDAGRLLISFARASVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCP9</accession>
    <name>W4KCP9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lignin medium expressed protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lep12</name>
        <name evidence="2" type="ORF">HETIRDRAFT_148569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545399.1">
        <property type="nucleotide sequence ID" value="XM_009547104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCP9"/>
    <dbReference type="GeneID" id="20667279"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_148569"/>
    <dbReference type="HOGENOM" id="CLU_1949082_0_0_1"/>
    <dbReference type="InParanoid" id="W4KCP9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="129" mass="13170" checksum="212AECDF99D03FE2" modified="2014-03-19" version="1">MGRDINPGGGSECSRTDGNPRPCRVSETARAPVHDPSISSGSSSESRLLAPRGLACAFTGWIASLRLDGCGAPPPKVWPWGSLSGATGASNARASSDLSGSNISIGGRKYVKDLGGSPSDVVASRILCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCR3</accession>
    <name>W4KCR3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Up-regulated during septation protein 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_155113</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543423.1">
        <property type="nucleotide sequence ID" value="XM_009545128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCR3"/>
    <dbReference type="GeneID" id="20667549"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_155113"/>
    <dbReference type="eggNOG" id="ENOG502QWKV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011428_0_0_1"/>
    <dbReference type="InParanoid" id="W4KCR3"/>
    <dbReference type="OrthoDB" id="5569911at2759"/>
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                <person name="Asiegbu F."/>
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                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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    </evidence>
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</entry>
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                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
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                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
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                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
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                <person name="Karlsson M."/>
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                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Raffaello T."/>
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                <person name="Velez H."/>
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                <person name="Yakovlev I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">TC 32-1</strain>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="113" mass="12320" checksum="2387C3378AD129C1" modified="2014-03-19" version="1">MSTPCISPVLAPMHSLPCHAVLKTQPCASTLHVQSSHRPSASLIRTRSAQRTSSRVIQPPSPLHLHRERANLFGLVSHHIALPISFHVDQKESICGQRRGVEGNRGQCPDGPL</sequence>
</entry>
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    <accession>W4KDW7</accession>
    <name>W4KDW7_HETIT</name>
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        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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            <taxon>Bondarzewiaceae</taxon>
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        </lineage>
    </organism>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545755.1">
        <property type="nucleotide sequence ID" value="XM_009547460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDW7"/>
    <dbReference type="GeneID" id="20675195"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_439821"/>
    <dbReference type="eggNOG" id="ENOG502QSY2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006019_2_2_1"/>
    <dbReference type="InParanoid" id="W4KDW7"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="28"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="656"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="692"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW83510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="919" mass="103330" checksum="3D2A62325F749C79" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEG9</accession>
    <name>W4KEG9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Esterase/lipase/thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_47144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543204.1">
        <property type="nucleotide sequence ID" value="XM_009544909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEG9"/>
    <dbReference type="FunCoup" id="W4KEG9">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KEG9"/>
    <dbReference type="GeneID" id="20677395"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_47144"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042179_1_0_1"/>
    <dbReference type="InParanoid" id="W4KEG9"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF31">
        <property type="entry name" value="STERYL ACETYL HYDROLASE MUG81-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="47"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW83715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="298" mass="32763" checksum="30D1702A4284ABAB" modified="2014-03-19" version="1">MVSVMGSTTPLYEKWARQTKLEVLSDEISEGAKLHWVGSRKYERVFLYFHGGGFSLPLNPQEQLNFLHKVQRDLQTSVGDVGVIAFEYSLTPSSPFPTQLRQVNAAISYLISKGTAPANIILGGDSAGGNLVLQFASHILHPLQNIPAPATSGPLGGALLISPWVTFDDSSPSFAENDKLDTTSRAILNFLADLVRPGITPETRAYFEPFAADDSWWTGLDKVFHRILSTAGSAECLRDPILAFGETLKKHVEDTTVVLEKNGVHEDVLRDFGVGQGEKSDAYKLDIEWLSDTFKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEK1</accession>
    <name>W4KEK1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 16">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HETIRDRAFT_438811</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="function">
        <text evidence="16">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543499.1">
        <property type="nucleotide sequence ID" value="XM_009545204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEK1"/>
    <dbReference type="FunCoup" id="W4KEK1">
        <property type="interactions" value="453"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KEK1"/>
    <dbReference type="GeneID" id="20675079"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_438811"/>
    <dbReference type="eggNOG" id="KOG0070">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_9_3_1"/>
    <dbReference type="InParanoid" id="W4KEK1"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 13 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 16" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 16" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ETW83745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="181" mass="20527" checksum="BFB38D5F43CC61DA" modified="2014-03-19" version="1">MGLSVSRLLSGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGIIFVVDSNDRERVSEAREELQRMLNEDELRDALLLVFANKQDLPNAMNASEITDKLGLQGLRQRTWYIQAACATSGDGLYEGLEWLSANIKRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEN9</accession>
    <name>W4KEN9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase family 125 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_48511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543241.1">
        <property type="nucleotide sequence ID" value="XM_009544946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEN9"/>
    <dbReference type="STRING" id="747525.W4KEN9"/>
    <dbReference type="GeneID" id="20678071"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_48511"/>
    <dbReference type="eggNOG" id="ENOG502QR7D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023537_1_1_1"/>
    <dbReference type="InParanoid" id="W4KEN9"/>
    <dbReference type="OrthoDB" id="7771656at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047:SF0">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028846">
        <property type="entry name" value="UCP028846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844248" description="Glycoside hydrolase family 125 protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="54457" checksum="B565BF64134E5C01" modified="2014-03-19" version="1">MRATILGIFGGVSSVIAQGCPDYTIYAQTPHGVISSGPLSLPYMRPALECRTFNSSAVERVIDDMKSRFKDPDIARLFENTFPNTLDTTIRYFNSTENLAFIITGLVVYRSLLSTDPELALLVKAVINNEARYIFQYPYCGAFQPPPESGLSPSHNDWADGVTVNPPVDNQTVFECKYEIDSLCGFIKLSRSYYQATNDSSFMNQNWAWAIDQIFRVIWEQSQSSFDDDFNFVSYYNWTGGNGALSPAVNNDGNGEPKAYNGLVGTHHRPSDDLSTYAFLTPANAMLSVELGHLASMLDQVQQLKNVSKLAKKYSSTIKKAIWNHTVVDGIFAYETNGFGGRYVMDDANVPSLLSLPYLGFLDKSDPTYVTTRKLLLSRRNPYYAAGKSFQGIGGPHVDAWHPWLMSQISAIFGTDDDEEIHQSLYLIANNTAGLGLIHESQNIYNNSDYTRPWFAWANSYFAEMILDLAERKPHLIFTDSRSNLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFG6</accession>
    <name>W4KFG6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HBS1-like protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_170967</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544138.1">
        <property type="nucleotide sequence ID" value="XM_009545843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFG6"/>
    <dbReference type="STRING" id="747525.W4KFG6"/>
    <dbReference type="GeneID" id="20668313"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_170967"/>
    <dbReference type="HOGENOM" id="CLU_154022_0_0_1"/>
    <dbReference type="InParanoid" id="W4KFG6"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015033">
        <property type="entry name" value="HBS1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037189">
        <property type="entry name" value="HBS1-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08938">
        <property type="entry name" value="HBS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109732">
        <property type="entry name" value="HBS1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HBS1-like protein N-terminal" evidence="7">
        <location>
            <begin position="13"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW84469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="92" mass="10335" checksum="02A29592B9D11D4A" modified="2014-03-19" version="1">MSRHRFVRNLDLDDERDDGALSDGGGEDIPPEEQAQMESGLEHIRAVLGSEAESGLSDSVIRETLWDSYFDVEKSVEWLMGISRHFTIPGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFK4</accession>
    <name>W4KFK4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_425910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544275.1">
        <property type="nucleotide sequence ID" value="XM_009545980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFK4"/>
    <dbReference type="GeneID" id="20674051"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_425910"/>
    <dbReference type="HOGENOM" id="CLU_353756_0_0_1"/>
    <dbReference type="InParanoid" id="W4KFK4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="574"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="651"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="731"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="882"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="494"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="574"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="743"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="762"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="816"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="894"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW84628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="914" mass="99457" checksum="8867F7DB4D80195A" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFK8</accession>
    <name>W4KFK8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Poly(A) polymerase</fullName>
            <ecNumber evidence="13">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HETIRDRAFT_472544</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Polymerase that creates the 3'-poly(A) tail of mRNA's.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions. Also active with manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="13"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543810.1">
        <property type="nucleotide sequence ID" value="XM_009545515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFK8"/>
    <dbReference type="FunCoup" id="W4KFK8">
        <property type="interactions" value="690"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KFK8"/>
    <dbReference type="GeneID" id="20677460"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_472544"/>
    <dbReference type="eggNOG" id="KOG2245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011511_4_1_1"/>
    <dbReference type="InParanoid" id="W4KFK8"/>
    <dbReference type="OrthoDB" id="412748at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.590:FF:000003">
        <property type="entry name" value="Poly(A) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000002">
        <property type="entry name" value="Poly(A) polymerase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014492">
        <property type="entry name" value="PolyA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018425">
        <property type="entry name" value="PolyA_polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="19">
        <location>
            <begin position="9"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="18">
        <location>
            <begin position="207"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="17">
        <location>
            <begin position="354"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="519"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="101"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="234"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR018425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ETW84100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="625" mass="69486" checksum="134CC226977632CA" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFN6</accession>
    <name>W4KFN6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_102501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845364" evidence="1">
        <location>
            <begin position="24"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="152" mass="16025" checksum="4688CB1376AA57E7" modified="2014-03-19" version="1">MAFSVPKLFIFAAVLACAFVANAGPLSRRQVGNAQCNIDRLKFVVNLQETSDQINKLATELANTNFSSTVDSAQSGIDGAFQATDGIADAIFSNQTAPPELRNQVGGNLTIVLKALLSINTTDPTASATLENAKSFFQTAAEASNDVVEDCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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    <name>W4KFW1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">HETIRDRAFT_313600</name>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="20670048"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_313600"/>
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    <dbReference type="InParanoid" id="W4KFW1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845367" evidence="2">
        <location>
            <begin position="32"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW83941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="118" mass="13236" checksum="D75A7BA6E6DFFBB1" modified="2014-03-19" version="1">MSVWRLESSLTLSRRFALSLVLALSCSVCTPDMLLTCHPTHYLVDSTLADCRYPGDSFRPLCPMPVPSDILGSHCTASLIYRVSFGLLLVRYIHPSVLCTLMSVLLYSYVWFLVGFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGD7</accession>
    <name>W4KGD7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543842.1">
        <property type="nucleotide sequence ID" value="XM_009545547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGD7"/>
    <dbReference type="GeneID" id="20668296"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_170623"/>
    <dbReference type="HOGENOM" id="CLU_2979354_0_0_1"/>
    <dbReference type="InParanoid" id="W4KGD7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="58" mass="6628" checksum="1547EE5159AB5E19" modified="2014-03-19" version="1">MSIVWRPSLHQDEPIESHSAYHSQDNKDYLTPRVASGPRSPYKCFSNTKLPPHLSSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGT5</accession>
    <name>W4KGT5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_101156</name>
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    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541958.1">
        <property type="nucleotide sequence ID" value="XM_009543663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGT5"/>
    <dbReference type="GeneID" id="20665738"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_101156"/>
    <dbReference type="HOGENOM" id="CLU_2133815_0_0_1"/>
    <dbReference type="InParanoid" id="W4KGT5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="113" mass="12204" checksum="50E064AA21DB8384" modified="2014-03-19" version="1">MVTSYGPIAASADPEASTRCRRNPRKLFSLRNSILDVEQPVNATHSLPSGPFRRLASAHLLDSTSHRDIPPSVHSGDLSDTSSSRTRGSTGPAYPISLRPPLTLMSVWEPLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGW9</accession>
    <name>W4KGW9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_312224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544222.1">
        <property type="nucleotide sequence ID" value="XM_009545927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGW9"/>
    <dbReference type="STRING" id="747525.W4KGW9"/>
    <dbReference type="GeneID" id="20669936"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_312224"/>
    <dbReference type="eggNOG" id="ENOG502SDNV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048619_0_0_1"/>
    <dbReference type="InParanoid" id="W4KGW9"/>
    <dbReference type="OrthoDB" id="3363286at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW84570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="448" mass="51331" checksum="DE04AEE3F104E3EA" modified="2014-03-19" version="1">MPRLIPRLLESLKATANTPTGKKVRPIYPASRGRVSLRQPVPPSPDFFSSRTRSILLDQQNPVLHPKDFVQHKSLPPRVRLHRNHRKRVVERDGTVGVDVPREMLAIERQWWANPYLRMLSTPLRRCTMTMQHLPTDFLIRLSPRRITPPRTSSQRTTYALLPDGLEHPKFKNLYSRKGVYISCRRDVLPHLNSLMRAPLDVKITPTRALPFYVSHLLRLRVLQDLEILTAQLEANPANAESVPLLRRLTRRELKAIRETNIIPFEGAVAVLIVPPVNRDPSTKERVAPHASSLPEHDHVIAPTTRTSPQVSSLPISVLHPTSSPEDYDSVSDFITPTQIPLYNGASLFPSKGQRAALHSRLSKLLLVERRARYKQHGRINSSDKMHYPQKDDKWARGDEKASHAFLLYSTGESVKRADTVPLAIALWRLRMWEKHDWENNDKWASII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHA9</accession>
    <name>W4KHA9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_311229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542116.1">
        <property type="nucleotide sequence ID" value="XM_009543821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHA9"/>
    <dbReference type="GeneID" id="20669852"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_311229"/>
    <dbReference type="HOGENOM" id="CLU_1943117_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHA9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="130" mass="14686" checksum="E36E028A35DBD453" modified="2014-03-19" version="1" fragment="single">LGTHLTSTLISCLIFYLEALFTIKTYIHLWNKPAFAPHSSELICTRLNHRNCLRQLPKTYHPCRSASFAFILVSLLVPPSSLVYCQSPVWLLKHVVVGRDTTFSLPTALPTRPTERSVGVRRSPETVRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHH2</accession>
    <name>W4KHH2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_150264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542157.1">
        <property type="nucleotide sequence ID" value="XM_009543862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHH2"/>
    <dbReference type="GeneID" id="20667357"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_150264"/>
    <dbReference type="eggNOG" id="ENOG502SIZI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006410_5_0_1"/>
    <dbReference type="InParanoid" id="W4KHH2"/>
    <dbReference type="OrthoDB" id="2881271at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="156"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="630" mass="72279" checksum="1DC88049B4D9B435" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHR9</accession>
    <name>W4KHR9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">L-dopachrome isomerase</fullName>
            <ecNumber evidence="9">5.3.2.1</ecNumber>
            <ecNumber evidence="8">5.3.3.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-dopachrome tautomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phenylpyruvate tautomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_470362</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-phenylpyruvate = enol-phenylpyruvate</text>
            <dbReference type="Rhea" id="RHEA:17097"/>
            <dbReference type="ChEBI" id="CHEBI:16815"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="EC" id="5.3.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-dopachrome = 5,6-dihydroxyindole-2-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13041"/>
            <dbReference type="ChEBI" id="CHEBI:16875"/>
            <dbReference type="ChEBI" id="CHEBI:57509"/>
            <dbReference type="EC" id="5.3.3.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.1" evidence="9"/>
    <dbReference type="EC" id="5.3.3.12" evidence="8"/>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542246.1">
        <property type="nucleotide sequence ID" value="XM_009543951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHR9"/>
    <dbReference type="STRING" id="747525.W4KHR9"/>
    <dbReference type="GeneID" id="20677342"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_470362"/>
    <dbReference type="eggNOG" id="KOG1759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129906_1_0_1"/>
    <dbReference type="InParanoid" id="W4KHR9"/>
    <dbReference type="OrthoDB" id="255819at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004167">
        <property type="term" value="F:dopachrome isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050178">
        <property type="term" value="F:phenylpyruvate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954:SF6">
        <property type="entry name" value="MACROPHAGE MIGRATION INHIBITORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW85382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="120" mass="13336" checksum="B8C45FEC897F043A" modified="2014-03-19" version="1">MPTLALTTNVKLADPKAFALEFSKAGAQILGKPEAYISVLYHYEEILTFNGTFDPALSLEITSLDNISPEANEVYSKALFEFFEKHLGVSSARGYINFNDPGRAFLGYKGTTFEQIFKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHU0</accession>
    <name>W4KHU0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_48484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543238.1">
        <property type="nucleotide sequence ID" value="XM_009544943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHU0"/>
    <dbReference type="GeneID" id="20678068"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_48484"/>
    <dbReference type="eggNOG" id="ENOG502S5IV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2360802_0_0_1"/>
    <dbReference type="InParanoid" id="W4KHU0"/>
    <dbReference type="OrthoDB" id="2742659at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW84646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="92" mass="10306" checksum="54278BDA69FD1981" modified="2014-03-19" version="1" fragment="single">PIFNSGHKSIMVWGCIAHSVKGLLIKLEFPPIIMSEKGQRQGRGLCAKEYVAQVLEGPLKNFFDKMEQQWMCLMLVVRDGAPAYTSHLTKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIG7</accession>
    <name>W4KIG7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_424546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541995.1">
        <property type="nucleotide sequence ID" value="XM_009543700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIG7"/>
    <dbReference type="GeneID" id="20673978"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_424546"/>
    <dbReference type="HOGENOM" id="CLU_785401_0_0_1"/>
    <dbReference type="InParanoid" id="W4KIG7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="353" mass="37612" checksum="9AE2A16E35C76341" modified="2014-03-19" version="1">MLIVLPLGQLQLTTRHSTLQYLISVTYCHTQSNIHMGRPKHPVCGPPPINRPPSKGKTFTSKMKGSDARDPRGDNPSTHDALPGSSIGGCARDLNARTLYVGGIDVLVGHARDHNATGSNATGSNSVHEHVAGCGNATVGHALGGNSASKHIAGGGNTLGRIASGSDTSGRNSGGGHIAGRMAMVVKGMVSVRKTMAANCRYCVILRRLDSLVAWHAAFKHTRAVEPPHMQGGDSRAGRTRPTNLSGRWDEDPTGGKATATTISYKGDRGLKAGNAMAVNMSSRRGRYSIAGNVIYASEADRWGRDSDGVDNTYAFASSRDARDRHMLVQDVTIEEWSLRVSSLRPCFYMRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIQ4</accession>
    <name>W4KIQ4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_109218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544552.1">
        <property type="nucleotide sequence ID" value="XM_009546257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIQ4"/>
    <dbReference type="GeneID" id="20666421"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_109218"/>
    <dbReference type="HOGENOM" id="CLU_2306502_0_0_1"/>
    <dbReference type="InParanoid" id="W4KIQ4"/>
    <dbReference type="OrthoDB" id="3063394at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW84931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="100" mass="10221" checksum="B240A5C6275AE908" modified="2014-03-19" version="1">MLAIPALMTRAKTAKKGIGVYTSSSAGRPHATPSLKGGTTQCILSQPGFLQPTPALMSPANCLGPVPGTGIGMYATCTIAVEELIVSERPLLVVPGAYHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>W4KK27</accession>
    <name>W4KK27_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="16">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HETIRDRAFT_60087</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="16"/>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541825.1">
        <property type="nucleotide sequence ID" value="XM_009543530.1"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KK27"/>
    <dbReference type="GeneID" id="20678494"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_60087"/>
    <dbReference type="eggNOG" id="KOG0206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000846_5_2_1"/>
    <dbReference type="InParanoid" id="W4KK27"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000014">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF153">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1060"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1091"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1141"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1177"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1208"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1249"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="18">
        <location>
            <begin position="54"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="19">
        <location>
            <begin position="1028"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="549"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1304"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1359"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1307"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1374"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="13">
        <location>
            <position position="510"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="510"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="510"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="648"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="691"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="724"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="758"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="838"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="839"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="840"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="976"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="982"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1002"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1005"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1006"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1006"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ETW86202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1404" mass="156302" checksum="A42E4E4891B3B199" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKL7</accession>
    <name>W4KKL7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_449127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_449127"/>
    <dbReference type="HOGENOM" id="CLU_1938436_0_0_1"/>
    <dbReference type="InParanoid" id="W4KKL7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="49"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="130" mass="13386" checksum="5AA179F3C54A9EFB" modified="2014-03-19" version="1">MLPAPAPGPPPHLFPYPAAPSILHSANLSVISRPFLGLSLLLFVSSSAPRTASSPASKTPVPPTPASAHPHLLPHTLPTVSYSQLNTAPAPCAPAPAHTHTKQRPLPYSGLSLNLALPLPPLSLPLHPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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    <name>W4KL72_HETIT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">HETIRDRAFT_145093</name>
    </gene>
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        <lineage>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009542290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KL72"/>
    <dbReference type="GeneID" id="20667059"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_145093"/>
    <dbReference type="HOGENOM" id="CLU_2126914_0_0_1"/>
    <dbReference type="InParanoid" id="W4KL72"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="114" mass="12629" checksum="C9C2E49FEDA219DB" modified="2014-03-19" version="1" fragment="single">MATIDVTPSATAWRPTGPVPMTILSWSKLRSTYGTPVWATEWLEDCLNCEIQIQQHEVQPNNIVYEQRRIVLDGSDTLTDADIARKEGYRAKAEGVDGLTLREKRGGDGRLAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLA0</accession>
    <name>W4KLA0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_167976</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542632.1">
        <property type="nucleotide sequence ID" value="XM_009544337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLA0"/>
    <dbReference type="GeneID" id="20668142"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_167976"/>
    <dbReference type="HOGENOM" id="CLU_1038501_0_0_1"/>
    <dbReference type="InParanoid" id="W4KLA0"/>
    <dbReference type="OrthoDB" id="2758459at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="268" mass="29625" checksum="FDD1C3CBD29D5F10" modified="2014-03-19" version="1">MTATPSSFSSSSPAFSPFSSNQLKLPYQTDSSCVYHQSHSSQSLVSNSNDYNDILRILIKADHDMLVRAGNCPYNQHLQQLAQAESQHMALFAQIVLYKNAYNKIITAIPQLLSTTSNPFSHPIPSMPVSPSVNTPIAITWSMQWCPSRILLGQDMIMPLAPNMDSDCSKLPYFSRKGWNSQEKGKAGKGGPQSENVGLQFAEDINRQAVPYVVAKEMQAMLNSLFHSLLANGQAAEVSNSFTHEARMYIHVTMSNHFPLLLLCEGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLA4</accession>
    <name>W4KLA4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_310299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542637.1">
        <property type="nucleotide sequence ID" value="XM_009544342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLA4"/>
    <dbReference type="GeneID" id="20669770"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_310299"/>
    <dbReference type="HOGENOM" id="CLU_2942016_0_0_1"/>
    <dbReference type="InParanoid" id="W4KLA4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="60" mass="6528" checksum="6FC597E0EEF8ABD0" modified="2014-03-19" version="1" fragment="single">LSSVGWGPTVFGNSRRLRYLSSAVRYLPKASQIPPSEPSAGACSSPASKYIVKHAHRLRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLR1</accession>
    <name>W4KLR1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_58737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540382.1">
        <property type="nucleotide sequence ID" value="XM_009542087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLR1"/>
    <dbReference type="GeneID" id="20678448"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_58737"/>
    <dbReference type="eggNOG" id="ENOG502S04M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_756547_0_0_1"/>
    <dbReference type="InParanoid" id="W4KLR1"/>
    <dbReference type="OrthoDB" id="2392789at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046921">
        <property type="term" value="F:alpha-(1-&gt;6)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132">
        <property type="entry name" value="ALPHA- 1,6 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132:SF29">
        <property type="entry name" value="ALPHA-(1,6)-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="361" mass="40773" checksum="C4D15B92CE9CB59F" modified="2014-03-19" version="1">MLDGYVGLSADLALMAQAAALAKERNRTFLVDDTYWNRGKWIDYFQDVRARQPGPEPGCRAPPSEELVACPRTARHWVINSRTAKWHFGHGFSENYEDAYARQLNRLKVIYERARESLQHTIRPNAATALLIRSVRAEFASLLPNSTSGLSSSDVGRYIAVHIRRGDRYGLSWKYHGKYIPIEDYAEATSSTWSRLFLDPDLPPSSHPPSPVVYLAFDDPTTQENYRAQLPADTTLFSLVESTDGELRALSSPIAYVQKEFDALWEAERVKRTRGMVVDFAMMGGFWNWESEGNIVPGAVVCTIGSNACRLSATGLGWDRAFGHVFGDHVEGNIDEQYKRWVEIDEKGAVEPVWQAFELFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLS7</accession>
    <name>W4KLS7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase F(0) complex subunit e, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_306580</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Subunit e, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase e subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540763.1">
        <property type="nucleotide sequence ID" value="XM_009542468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLS7"/>
    <dbReference type="STRING" id="747525.W4KLS7"/>
    <dbReference type="GeneID" id="20669420"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_306580"/>
    <dbReference type="eggNOG" id="ENOG502SDS3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159435_2_0_1"/>
    <dbReference type="InParanoid" id="W4KLS7"/>
    <dbReference type="OrthoDB" id="2125027at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008386">
        <property type="entry name" value="ATP_synth_F0_esu_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05680">
        <property type="entry name" value="ATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 11" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW86778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="82" mass="9511" checksum="A4F6B599973380FE" modified="2014-03-19" version="1" fragment="single">VVRYTALLSGVFYGIAHRRTLQKTHDEEKARHAVHDRTNLIAQAKEAWKRKQEGSKDGVVTDPEDSRFDLEKLFAKWESESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMK0</accession>
    <name>W4KMK0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_238204</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541014.1">
        <property type="nucleotide sequence ID" value="XM_009542719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMK0"/>
    <dbReference type="FunCoup" id="W4KMK0">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KMK0"/>
    <dbReference type="GeneID" id="20668802"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_238204"/>
    <dbReference type="eggNOG" id="KOG1087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036827_3_1_1"/>
    <dbReference type="InParanoid" id="W4KMK0"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14232">
        <property type="entry name" value="GAT_LSB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16980">
        <property type="entry name" value="VHS_Lsb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044103">
        <property type="entry name" value="GAT_LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045007">
        <property type="entry name" value="LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789:SF1">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="4">
        <location>
            <begin position="30"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="5">
        <location>
            <begin position="182"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="150"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="359"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW87068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="50511" checksum="DC23B58CD4F90BE3" modified="2014-03-19" version="1" fragment="single">MSAIALGKQVAAAFGREKPRSSITEWIDILTAPSYADEVYDGIPELIDSINLQPTGPAEASRAIRKKLKHGNAHQQYRALVILKALVENCGHKFQTTFADGQLTDAIRHLASDSSTDEKVKRKLNAVLASWRNQFKDDHSMTLVANMFKPRRPSEPARRSVDHEVEARESEYEKRRREEKIAKEEAKKKAKLDKEAEKERLKNEEAARRQRAKDKTTRKPFNFEQEKPQVLNSIASASSAANNLVNAITLVNTEHDSLQANERVQECLGKAKQARKQIVRYIQLVEDEEFIGTLIETNDRIIAAIETYDKLSNPHVTEQDIADVQEGLAAANIHDSELQKLQIKQRAALQRAVNRDRSAVLEEQNERSRQPQSPLHPDLQDLSFGTLGVDQQNLPPPIRPNGPYSSDDDRRGGSLSDFSDYQSSDEDAHHQRAGPSSRRTYVTVSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNS0</accession>
    <name>W4KNS0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Jacalin-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_424001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540985.1">
        <property type="nucleotide sequence ID" value="XM_009542690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNS0"/>
    <dbReference type="STRING" id="747525.W4KNS0"/>
    <dbReference type="GeneID" id="20673949"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_424001"/>
    <dbReference type="eggNOG" id="ENOG502QPIS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032141_0_0_1"/>
    <dbReference type="InParanoid" id="W4KNS0"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09615">
        <property type="entry name" value="Jacalin_EEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF1">
        <property type="entry name" value="SPHINGOMYELINASE DDB_G0288017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01419">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00915">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845619" description="Jacalin-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Jacalin-type lectin" evidence="2">
        <location>
            <begin position="312"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW87035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="441" mass="47077" checksum="A4C1C63877F4238F" modified="2014-03-19" version="1">MLHLALAVSLAVSLSRIAHVQASGTFNILSMNVAGLPEILNGNGESGDKTTNTMVIGQDFATYDYDLIHVQEDFNYHATLYKYDTHPYRTATSGGAGIGSGLNSLSNYDWIDFDRTKWNDCSDASENDCLTPKGFTHMRWRIAEGVYIDAFNLHTDAGTEDGDESARRSNIQQVADYVDANASGNPVLIFGDTNSRYTRSADNIPTILSQNGLTDAWVQLVRNGVAPVAGTDALVCPDGVPTNTSCEVVDKVLYRGSKSVTLTATAFFYDTARFLSTDLATLTDHNPVRVEFKWAGANGFSQSDLYGGPHGSSWFNDLPSLPTSPKVASVTLRGAKRLDAVSFTLSTGAVLSHGGTGGDASSLTLASGEYFTSAKLCWGEYNGHTRNFYALLTTSSGRTVSAGTTTDDCATVTAPSGSGIVASYGQSGDEMDLLGWIYSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNW6</accession>
    <name>W4KNW6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DinB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_121883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541425.1">
        <property type="nucleotide sequence ID" value="XM_009543130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNW6"/>
    <dbReference type="STRING" id="747525.W4KNW6"/>
    <dbReference type="GeneID" id="20666759"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_121883"/>
    <dbReference type="eggNOG" id="ENOG502S7Z8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083400_1_0_1"/>
    <dbReference type="InParanoid" id="W4KNW6"/>
    <dbReference type="OrthoDB" id="5564877at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39473">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39473:SF1">
        <property type="entry name" value="DINB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DinB-like" evidence="1">
        <location>
            <begin position="28"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="182" mass="20192" checksum="3C1F7E531894C72C" modified="2014-03-19" version="1">MRSLEQLLDVSTKVLAQAIDLLDNSLTSDDQLTVSSKYLPGSTIGKHLRHARDHFSLLLECITSSPPRVLSYDKRSRNTPMESSRQAAREAIQETIAKLKAVVPNSKLDAPLSLDAVTPYEQTFQSTFGRELWFAGLHAVHHWSMVRVITGELNIQLEESFGFAPSTLVHQGKEAPLGKAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNY6</accession>
    <name>W4KNY6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_308051</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541314.1">
        <property type="nucleotide sequence ID" value="XM_009543019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNY6"/>
    <dbReference type="FunCoup" id="W4KNY6">
        <property type="interactions" value="760"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KNY6"/>
    <dbReference type="GeneID" id="20669545"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_308051"/>
    <dbReference type="eggNOG" id="KOG3285">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072097_0_0_1"/>
    <dbReference type="InParanoid" id="W4KNY6"/>
    <dbReference type="OrthoDB" id="1806at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF11">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="7">
        <location>
            <begin position="18"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW87409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="214" mass="24048" checksum="990AA0DB9E3EE859" modified="2014-03-19" version="1">MAPTKTKKAPTRQAITLKGSTNLVTEFFKYAVNTILFQRGVYPSDDFHMVKKYGQTVLVTQDLALENYLDKILKQVNTWLLTGAVTQLVVAIISKDTRTPLERWVFDINLVQQSSDKSPEAAPPPAKPEADIQAEIRSILKQIVSTVTFLPIIDEPTVFNILAYTSESADVPADEWVDTDPLAIEASKSQQVKLRSFSTDVHRIEAMVAYRYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNZ3</accession>
    <name>W4KNZ3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">V-type proton ATPase subunit F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_40619</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540310.1">
        <property type="nucleotide sequence ID" value="XM_009542015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KNZ3"/>
    <dbReference type="FunCoup" id="W4KNZ3">
        <property type="interactions" value="246"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KNZ3"/>
    <dbReference type="GeneID" id="20672518"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_40619"/>
    <dbReference type="eggNOG" id="KOG3432">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135754_0_0_1"/>
    <dbReference type="InParanoid" id="W4KNZ3"/>
    <dbReference type="OrthoDB" id="10261947at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10580:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="entry name" value="ATPase, V1 complex, subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005772">
        <property type="entry name" value="ATPase_V1-cplx_fsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01101">
        <property type="entry name" value="V_ATP_synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861:SF2">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015945">
        <property type="entry name" value="ATPase_V1_F_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="AtpF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR015945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW87563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="119" mass="13390" checksum="0BB8F0E64FE28B30" modified="2014-03-19" version="1">MTSTSFKDRNLLAVIGDEDTVTGLLLAGIGHITQQQKKNFLVVDSKTQVSAIEAAFQEYTERKDIAILLINQHVAEKIRPTVDRYQQAFPSLLEIPSKDHPYDPAKDSVLKRVHKLFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPL7</accession>
    <name>W4KPL7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_378186</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541231.1">
        <property type="nucleotide sequence ID" value="XM_009542936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPL7"/>
    <dbReference type="STRING" id="747525.W4KPL7"/>
    <dbReference type="GeneID" id="20671916"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_378186"/>
    <dbReference type="eggNOG" id="ENOG502S54T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003767_0_0_1"/>
    <dbReference type="InParanoid" id="W4KPL7"/>
    <dbReference type="OrthoDB" id="1112565at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF35">
        <property type="entry name" value="MUSCLE LIM PROTEIN MLP84B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="183"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="565"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="33"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="330"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="397"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="479"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="652"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="741"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="794"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="910"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="428"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="485"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="653"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="805"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="825"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="835"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="916"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW87315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="970" mass="102590" checksum="97FA97E3CABDD6D3" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4KS19</accession>
    <name>W4KS19_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_413759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541713.1">
        <property type="nucleotide sequence ID" value="XM_009543418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KS19"/>
    <dbReference type="STRING" id="747525.W4KS19"/>
    <dbReference type="GeneID" id="20673130"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_413759"/>
    <dbReference type="eggNOG" id="ENOG502SAW1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028914_0_0_1"/>
    <dbReference type="InParanoid" id="W4KS19"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW87856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="44886" checksum="33C67A26C6CC7A1E" modified="2014-03-19" version="1">MLRMTCPHFLSHDLVRETFLRGDTLKLTSSLPVNKTTVGSVINMGSGLIHLELIGFDTILDQGFAAVVTHLTSLRVLNLRGCTKVGQKTIETAAKRCPNLTTVNLNYTSVSPVSLVPLLLTCQKHLEVLKLAGISSWANTTIVKALSLLPQGGVLCFPALRTLKLRQTSLTDISLNLLLPSCPALRRLDISFTGIRHPHQFMQGSRIALEKLSLTSTAVSSDFLVTAISCIPSLRILSIGALGGGPGQAPAIRNTTAMTLTDDALSCLVDVLDTYESIKSISLVGNTKLGMTGGRNRALADFVARIGRRLKVLNLAGIPSLRSEDLIGLLVDNAGQEPSRLQELILNNTAVDDDAAPYISSCSSLETLEVAGTKFTSRGLFTIVDACTLLTKLDLTSCRGVRIVDRRRFFQVCDYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMP7</accession>
    <name>W4JMP7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_331858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553266.1">
        <property type="nucleotide sequence ID" value="XM_009554971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JMP7"/>
    <dbReference type="FunCoup" id="W4JMP7">
        <property type="interactions" value="206"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JMP7"/>
    <dbReference type="GeneID" id="20671685"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_331858"/>
    <dbReference type="eggNOG" id="KOG2961">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056221_1_0_1"/>
    <dbReference type="InParanoid" id="W4JMP7"/>
    <dbReference type="OrthoDB" id="198652at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027706">
        <property type="entry name" value="PGP_Pase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09419">
        <property type="entry name" value="PGP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW74788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="279" mass="31277" checksum="57240204178CA631" modified="2014-03-19" version="1">MPFNLPGVLVPFHILINPRIILPSIAVADIRQLDFTALKRAGYRGAVFDKDNCLTIPHDDALVPELREAWQECQQTFGPGNVLIVSNSAGTRDDPGLLQAESVTHHLRAPVLRHKSLKPSYSCVRGVRSYFASLPSPVQPHDLVVIGDRIFTDVVLARRLAPRPWPWTQGQLLGKGETTEEKTELVDDRRESGPLAIWTTGVWKHEATLMRWAEKKLVAAAESWIQGAEGERRVIESRFVKPVTEAKVEPGTRSKMWYGRISTAAGWVGKQLRTVVRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMR9</accession>
    <name>W4JMR9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_157711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553319.1">
        <property type="nucleotide sequence ID" value="XM_009555024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JMR9"/>
    <dbReference type="GeneID" id="20667745"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_157711"/>
    <dbReference type="eggNOG" id="ENOG502SVPG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065000_0_0_1"/>
    <dbReference type="InParanoid" id="W4JMR9"/>
    <dbReference type="OrthoDB" id="2653987at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW74847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="31896" checksum="F7259CC585328672" modified="2014-03-19" version="1">MTSEAQQQPTNSNSTRHPTAIVHQRAFHAAASDHAVLQIIQIWQDRLQLISVVASFFTSIDSILLSLVSAQRDHKSTDGKLMDATIAGALIFHAGAAFTASFVLIRYKLNDAKNAPASPSPSPSNAAFYSTNDKQEDTNNINDISTTSTWPFFSVPHRSPAHPTSGPTSPAPLPFPLSLLSHATDLLNAITLTLGFGSRISVSRVHIFTLPWRQQDPSRDLPDEGAGDPDSDKGAVELTRLLTRCHAACTAFSLAGFVLLIVGVLAYVWEVLARSVSIFVSCCVGLVAFVWVVALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W4JN67</accession>
    <name>W4JN67_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_127040</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553439.1">
        <property type="nucleotide sequence ID" value="XM_009555144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JN67"/>
    <dbReference type="FunCoup" id="W4JN67">
        <property type="interactions" value="352"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JN67"/>
    <dbReference type="GeneID" id="20666968"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_127040"/>
    <dbReference type="eggNOG" id="KOG0975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031922_0_2_1"/>
    <dbReference type="InParanoid" id="W4JN67"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW74983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="367" mass="40068" checksum="E7808C4DF4840166" modified="2014-03-19" version="1">MLQIEKTHQRKTIPPANTLKTGHHFTDHMLTIPWILDGGWGTPKIQPYGPLSFEPSCSVFHYAHCLFEGLKAYRRADGRVTMFRPGMHMTRMNASAARITLPTFDGDELLKLIMELVRIDQAWIPQPTGQGLYIRPVLIGTQTKIGPWPPDAALLYVMCSPAGPYSSHPVALQATTGFTRASVGGTGDFKVGANYALGLLPQKQAASLGYDQILWLHGPEHYLTEAGTMNLFVVLKNATGALELVTPPLDGMILPGITRDSVLTIAREHVSGVRPLPKLPRKLTVTERPITMKEFQNAAESGSLLEMFGTGTAVVVSPVNRIGYMGKDIHIPGEADGMGPVSRPLWGELIGRQTGVMPCKWSIEVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNA2</accession>
    <name>W4JNA2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_423601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW75018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553470.1">
        <property type="nucleotide sequence ID" value="XM_009555175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNA2"/>
    <dbReference type="GeneID" id="20673918"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_423601"/>
    <dbReference type="HOGENOM" id="CLU_048769_0_0_1"/>
    <dbReference type="InParanoid" id="W4JNA2"/>
    <dbReference type="OrthoDB" id="3049938at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="365" mass="40638" checksum="B6D5C700205D359D" modified="2014-03-19" version="1">MTSKGKGGEVGRNSKEIWVYVGGPDSRKPIDAPLVAWEDRKAPLRTVTTLTQTKPGNIPVDIPKEVIEKEVILAGVLTLVDKEDPELTPGPSNPRCLDPNPDPIPGTRTANTNNEMSSDKGNKLKDFDGTRSKYQEWIYEYYMYILANPTKYTTDMDKILMVLSYMREGTALLMGKCSADEFVTDYLMTAGESGFDLESTVNYFRRAIYLEIFKQIYRLPEMPTTIDDWWRELQSIKSSVPTTMPRHNNPFCYDFSNAPTSMNNSVVPMAIDSIHTPLTDDERARLRAEGGVSSRVHEGGTRHVQQGSREVGYRPAQTGRALAGRGGGYGRALPARAQISGETATSGKSRSVVMTNLFWARLAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNB3</accession>
    <name>W4JNB3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_120455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW75033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553483.1">
        <property type="nucleotide sequence ID" value="XM_009555188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNB3"/>
    <dbReference type="GeneID" id="20666699"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_120455"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069180_0_0_1"/>
    <dbReference type="InParanoid" id="W4JNB3"/>
    <dbReference type="OrthoDB" id="2746711at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW75033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="272" mass="31573" checksum="C2FAE314141E849C" modified="2014-03-19" version="1">MLTNPRNPESKGPAIAKPTPFDGNRKRTEQFLHEIDLMILARKYDFPGEFAKIAYALSYMKGGSAELSGVDLETKKTHFLRGLKWELARGIYQDPAKQDTWEELVAKAKRHETMRIEEMRARDLRQGKYQVFTPSNYYSNIAPPRQERESQYVPMDVDAAEMEADAIRTRFKKLTPGERSQLAKEGKCFYCKKPGHMARGCPSRPKQRFPPPSRGRFQPKRRMMRAMEEEEGGDEEDQEEGKQRVAYIQQMMMGLSMDEIEEVRAFSESKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNE9</accession>
    <name>W4JNE9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PB1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_482796</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
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                <person name="Hietala A."/>
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                <person name="Hogberg N."/>
                <person name="James T.Y."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
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                <person name="Wiebenga A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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            <dbReference type="EMBL" id="ETW75194.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
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                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Lunden K."/>
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                <person name="Stahlberg J."/>
                <person name="Velez H."/>
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                <person name="Wiebenga A."/>
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                <person name="Yakovlev I."/>
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        </citation>
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                <person name="Cullen D."/>
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                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Lucas S."/>
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                <person name="Woodward S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="EMBL" id="ETW75405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
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                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
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    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="589"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SMART" id="SM00823"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW76143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1088" mass="119368" checksum="4C2C35D1B124D4C7" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JS52</accession>
    <name>W4JS52_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_328334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551304.1">
        <property type="nucleotide sequence ID" value="XM_009553009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JS52"/>
    <dbReference type="GeneID" id="20671409"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_328334"/>
    <dbReference type="HOGENOM" id="CLU_2558560_0_0_1"/>
    <dbReference type="InParanoid" id="W4JS52"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="82" mass="9441" checksum="A9B138546CB439CD" modified="2014-03-19" version="1">MSISFHTLSPEVQKRVRFDEEDSRALPCHSSISSLRFPQASFQGCVTYIYGIGSRARNDLRVYTLNSCCMLVSCRIYVRSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSL1</accession>
    <name>W4JSL1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_174525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551349.1">
        <property type="nucleotide sequence ID" value="XM_009553054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSL1"/>
    <dbReference type="GeneID" id="20668514"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_174525"/>
    <dbReference type="eggNOG" id="ENOG502SBYH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004591_2_1_1"/>
    <dbReference type="InParanoid" id="W4JSL1"/>
    <dbReference type="OrthoDB" id="2246127at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912:SF34">
        <property type="entry name" value="NOTOCHORD-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1037" mass="115434" checksum="FB7471D4E0A7B91F" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSM9</accession>
    <name>W4JSM9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_330113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552333.1">
        <property type="nucleotide sequence ID" value="XM_009554038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JSM9"/>
    <dbReference type="GeneID" id="20671550"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_330113"/>
    <dbReference type="HOGENOM" id="CLU_2184316_0_0_1"/>
    <dbReference type="InParanoid" id="W4JSM9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="109" mass="12312" checksum="95409E47EBEDBD36" modified="2014-03-19" version="1">MPVLQLFGCSWTLKITLIVLYFLKDPSLSPSTAVRIRSWELHLLYDSGSLPFDSHMPFTPETFPGLQIYQSNDQYQQANSDFRPTMSETVKPALRQSSRSTQGQGGTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTC4</accession>
    <name>W4JTC4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_455704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552367.1">
        <property type="nucleotide sequence ID" value="XM_009554072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTC4"/>
    <dbReference type="GeneID" id="20676654"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_455704"/>
    <dbReference type="HOGENOM" id="CLU_103448_0_0_1"/>
    <dbReference type="InParanoid" id="W4JTC4"/>
    <dbReference type="OrthoDB" id="3358294at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="196" mass="21540" checksum="3C0E17E1CA83C700" modified="2014-03-19" version="1">MSFSFIRAASVTWRSPQPDIHHHPFSPLTRALTIIPERPAKPPLPSSDAFDDFFGAARTTCTSDSRHHEHPIPSSPPMGTALPPAYAYPPPAPIHADPAFDESELPSYAQLEAVHARQPISAELESITLAPYFFKFDINAAPADWEMTKTPAKRNALFDTMRKAEYKWARRGIAAAALLSVMITAIVIIAVSLSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTM9</accession>
    <name>W4JTM9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_430180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551779.1">
        <property type="nucleotide sequence ID" value="XM_009553484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTM9"/>
    <dbReference type="GeneID" id="20674426"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_430180"/>
    <dbReference type="HOGENOM" id="CLU_1468344_0_0_1"/>
    <dbReference type="InParanoid" id="W4JTM9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046521">
        <property type="entry name" value="DUF6698"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20414">
        <property type="entry name" value="DUF6698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="184" mass="21185" checksum="4282DDD8A781E490" modified="2014-03-19" version="1">MFLPPLLPLPLEHVFAKKCATFKCKGKKKDKTRQKDQKKLYLKILKQVLDLVPGFSVKVESEDMTHIKEFVTDTWNKLKNNEIKVLAKHWPAFIYEDYQYDPSNCEKGLFHGHLLIYAWHAIYIGLLAARLGPSSKIARNVPQSHKHTATCAQYNDNSSHTLKACKAKMNTSTILTSKIYLPHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUD5</accession>
    <name>W4JUD5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Restriction of telomere capping protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_327170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RTC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550704.1">
        <property type="nucleotide sequence ID" value="XM_009552409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUD5"/>
    <dbReference type="GeneID" id="20671303"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_327170"/>
    <dbReference type="HOGENOM" id="CLU_1678133_0_0_1"/>
    <dbReference type="InParanoid" id="W4JUD5"/>
    <dbReference type="OrthoDB" id="128308at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039024">
        <property type="entry name" value="RTC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028094">
        <property type="entry name" value="RTC4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391:SF1">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14474">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01312">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Restriction of telomere capping protein 4 C-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW77162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="157" mass="17900" checksum="8653894515918CA6" modified="2014-03-19" version="1">MLDPTASPFYTELMELLVMKNSNNTFSIQGEYESLEAVGTGYYGLKGKEIMFWSLLALLELTHEHTVWTIPAWEFTNRVLIPEATVFFIQEDLNVTREHAIEIKIASSSYGMVAHPTNDELDFRELQATVRILRVIVEAEDSSLDVGERVNDKRGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUE3</accession>
    <name>W4JUE3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_454537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550715.1">
        <property type="nucleotide sequence ID" value="XM_009552420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUE3"/>
    <dbReference type="GeneID" id="20676529"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_454537"/>
    <dbReference type="HOGENOM" id="CLU_1713519_0_0_1"/>
    <dbReference type="InParanoid" id="W4JUE3"/>
    <dbReference type="OrthoDB" id="3259156at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW77173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="16582" checksum="F851071C173E4C62" modified="2014-03-19" version="1">MFPIPLSFIYMHVAPHDLSALIRVRRRCRTAAHSVLYFSACPDHMVDQCITVLASARDIAELVYNGLGLAHTLCSASSNLLLSMSSAWVTLLVPSSLSFISLSDAARSKPIACVVLQSINTYTLSTFFQPVFSRAQYGVASLTCDDANATGCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUK3</accession>
    <name>W4JUK3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleic acid-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_327712</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550769.1">
        <property type="nucleotide sequence ID" value="XM_009552474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUK3"/>
    <dbReference type="FunCoup" id="W4JUK3">
        <property type="interactions" value="177"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JUK3"/>
    <dbReference type="GeneID" id="20671354"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_327712"/>
    <dbReference type="eggNOG" id="ENOG502SBJ5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073626_2_0_1"/>
    <dbReference type="InParanoid" id="W4JUK3"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="88"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW77233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13938" checksum="034CDAD01FD4FE93" modified="2014-03-19" version="1" fragment="single">RPALHLHSFAKMPPMAFTGLVTKVGFMNKTATVTVSRWVFHKLTGKRILRSTKLLVHDEKNQLRMDDSVLIRNCPPISARKRFTLEKVVKSPEQERERAHAGLQHATETPAPPPPLEAQPTLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUZ1</accession>
    <name>W4JUZ1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_446302</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550869.1">
        <property type="nucleotide sequence ID" value="XM_009552574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUZ1"/>
    <dbReference type="STRING" id="747525.W4JUZ1"/>
    <dbReference type="GeneID" id="20675684"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_446302"/>
    <dbReference type="eggNOG" id="KOG2538">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010669_1_0_1"/>
    <dbReference type="InParanoid" id="W4JUZ1"/>
    <dbReference type="OrthoDB" id="10265211at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20704">
        <property type="entry name" value="Orc3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020795">
        <property type="entry name" value="ORC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045667">
        <property type="entry name" value="ORC3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040855">
        <property type="entry name" value="ORC_WH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07034">
        <property type="entry name" value="ORC3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18137">
        <property type="entry name" value="WHD_ORC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 N-terminal" evidence="6">
        <location>
            <begin position="58"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 3 winged helix C-terminal" evidence="7">
        <location>
            <begin position="571"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW77352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="693" mass="78489" checksum="69E8C2C63B4E7571" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JV33</accession>
    <name>W4JV33_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_328145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551615.1">
        <property type="nucleotide sequence ID" value="XM_009553320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JV33"/>
    <dbReference type="STRING" id="747525.W4JV33"/>
    <dbReference type="GeneID" id="20671394"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_328145"/>
    <dbReference type="eggNOG" id="ENOG502S8AN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_560268_0_0_1"/>
    <dbReference type="InParanoid" id="W4JV33"/>
    <dbReference type="OrthoDB" id="4851849at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="444" mass="50157" checksum="68B9119BDBDBF157" modified="2014-03-19" version="1">MATPEAFLSALYPLLPLFSTSKSARSLSGKVDGQVRVALDALAAISVANGTGDVVAVALDARPHETKLYVATNGDVKHEVEDHLISVWSCLGRIAKLANGRHSTTSSSDINAHRMDLTLQIYRFSRKKFRSEFEKHSEEFLRVFPQGHTSSVWNSLFDRDQYEVLGYIQSTFKSITDSVKVEKPTDNQVHSLAGLVDKLDRLHAHVNTKIFLEVRRYLRKVLSLRNHIEVLLQIACTKKFRSWFLPVMSVVKVPGMSQSYAVDMGNLYFTQQCFGSRGQFESVRPRWNTEVLEVVRSELINRHCSVSGHGQNTFTFARVFIHCECALAVYIDDHPGAKPFRFIGVSKLCCHGCYTFLRAYNKNVGSPFEFKGTHGKVYLPYVFPKIPSRSTLVSNAAIRRDMLKILKDDFHVAWTQPRRGRRYSDSTAASPPPPDTEQEDQGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W4JV38</accession>
    <name>W4JV38_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDB1- and CUL4-associated factor 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">WD repeat and SOF domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_37201</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="FunCoup" id="W4JV38">
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    </dbReference>
    <dbReference type="STRING" id="747525.W4JV38"/>
    <dbReference type="GeneID" id="20671845"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_37201"/>
    <dbReference type="eggNOG" id="KOG0268">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_033999_0_0_1"/>
    <dbReference type="InParanoid" id="W4JV38"/>
    <dbReference type="OrthoDB" id="10249065at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Sof1"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_PAC1"/>
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    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
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    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="107"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="287"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="330"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Sof1-like protein" evidence="11">
        <location>
            <begin position="363"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="424"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00032239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW77433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="454" mass="51066" checksum="7670136D0E565781" modified="2014-03-19" version="1">MVKISVLQHAPSAHLPARLGDPTPTQRNLDPNMHPFSRARERTRALNAAKMERMFAKPFIASLEGHMDAVEVMVRKPDSVTDVASGSWDGEIILYNLARRTRLAKFPGAHKGKVSGLCFADQTRILSCGIDHNIKMWDIRPSGDDLTGAGPSEPKPLHVYPGKTLFNSIDHHRNDPLFATASNIVQIWDETKSAPISNLTFPTSTETITSVRFNAAEPSVLASIGSDRTFTLYDIRTGKAERRLVMQMRNNSLAWSPTFPTSVLLASEDHNLYTFDIRSMETPTQIYKAHVAAVMSCDWSPTGQEFVSGGWDRTVRIWKEGHGSAPEVYHTKRMQRVLSTVFTADARFVLSGSDDGNVRVWKSNASEKLGIITARERAAIEYRDTLKERWKMDTQIGKVQRSRHIPKPVYKAAALKRTMLEAQRVKEERRRKHTRAGDNKPKAERKKVVIAEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVW6</accession>
    <name>W4JVW6_HETIT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_241095</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_241095"/>
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    <dbReference type="InParanoid" id="W4JVW6"/>
    <dbReference type="OrthoDB" id="3133286at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW77619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="133" mass="15476" checksum="8FC73BBA8CEE16A0" modified="2014-03-19" version="1" fragment="single">DVVVMTNPNEIDPENIKDILENEDSRFIRRPSRLINRSYTVLEYCLPGYQTLGRKLKVDILVSGWGNLDIPRISWRKLIDIDDIPVMPILPLLFLKMQGWDAHRMSPRRDFQAKEEGDIQDVEQLLNIACEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4JW34</accession>
    <name>W4JW34_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_460520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009552347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JW34"/>
    <dbReference type="STRING" id="747525.W4JW34"/>
    <dbReference type="GeneID" id="20677083"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_460520"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_6_4_1"/>
    <dbReference type="InParanoid" id="W4JW34"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF24">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="1">
        <location>
            <begin position="96"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW77096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="335" mass="37065" checksum="1A957B26302BF042" modified="2014-03-19" version="1">MSSSYLPTPTTKDLSILEPEFRDFIGNFPDTTETAETGDVVVNFMRSIPPRPHNDPRVIKQDIQVSSPNAPSTQPPVNVRVYSPKDVDPARPLPVLLWMHHGGFFSAGPLRLDPFCSAIAAEANIIMIAPAYRQTPEHPFPAPFDDCYEVLRWITTSPETSRYAIDSTKFAVGGTSVGGTVAIGLALKLREETGSTKAISLLLLDDTSFTDKPNTYSTFHNPINKIWNANVTRYAWQFYLPNGSDALDPVTRSYVVPALATDLTGLPQTMMMCAQWDDLTDDAIAFASRLLQAGIPTEIHTYRGTFHVSDKFLHNAKMSIRKRQNMVDALEAAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWT1</accession>
    <name>W4JWT1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_429094</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW77914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549929.1">
        <property type="nucleotide sequence ID" value="XM_009551634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWT1"/>
    <dbReference type="STRING" id="747525.W4JWT1"/>
    <dbReference type="GeneID" id="20674319"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_429094"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_1"/>
    <dbReference type="InParanoid" id="W4JWT1"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF5">
        <property type="entry name" value="2-DEHYDRO-3-DEOXY-D-GLUCONATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="18"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW77914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="266" mass="28192" checksum="C75A916A8BDC14D2" modified="2014-03-19" version="1">MDSTPSISAPQLFNLTGQNVLITGASRGIGAACAKALAEAGASVCLVLRAPAEGAQPNLDTVGAIRAMGVRAEYVYCDLSDLNAVKGLFQKALDAMGGQIHVLVNCAGIQRRSPSVDFSERDWDDVLDVNLKSVWLLSQAAGRHMVPLRRGKIINFASLLTFQGGLTVPAYAAAKGAVGQLTKALSNEWSQHNVQVNGICPGYIATDMNEKLLADPVRLRQISERIPAGRWGQPNDFAGPVVFLASSASQYVCGELLVVDGGWMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXL4</accession>
    <name>W4JXL4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">H+/Ca2+ exchanger Vxc1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_68332</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549688.1">
        <property type="nucleotide sequence ID" value="XM_009551393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXL4"/>
    <dbReference type="GeneID" id="20678855"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_68332"/>
    <dbReference type="eggNOG" id="KOG1397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008721_4_3_1"/>
    <dbReference type="InParanoid" id="W4JXL4"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF20">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="109"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="317"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW78302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="505" mass="54504" checksum="01EB7E6B9FDCD3C9" modified="2014-03-19" version="1">MPGDASALIASEKPRQPHSPSLERAEHGLSPSAPPPPHRAGSLSHGAPYAEHNGMARFWARFKGRGRKKVGWADSAKAIVFSSWLNAFLIFIPFAFVARYHESWGHGAAFAFAFLSIVPLEKLFDWGGEQLALYCGEDLGDLIVVTLNNAVEATLAIILLLKCELKLLQSTIAGVVLLHLLLVPGTAFLVGGARIWEQQLHPTRTQLNHTLLTLGVLALVVPAAFFAALDQGLTTNADGSESGGGVVVDALRADFLRLSRGFAIVLLVVYVCSRFYLHDPPGQDNAFRLPAGAPQEAIERERELANAEPEVNPVGCVVLLAVTVAIMAVMAEFLVESIEFVREQGNIQEEWFGLVLLPLISFSADGTVAIVYFARSLLQALLGSKPAPPPDSVAEAKAIDLSIQFTLFWLPFLVLLGWWTGRPLTFLFDLFEVTVLIGSCFLVNYITADAKTNWVEGIIMIAFYLMIGLSAWYYPGQAEIGVLDACRESIAEALAAGVGAGAGAE</sequence>
</entry>
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            <taxon>Heterobasidion</taxon>
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    </organism>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
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                <person name="Henrissat B."/>
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                <person name="Hogberg N."/>
                <person name="James T.Y."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
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                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="ETW78313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="569" mass="64460" checksum="F18BF45FB4B43AF3" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXZ7</accession>
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        </recommendedName>
    </protein>
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            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
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    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
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                <person name="Gonthier P."/>
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                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Velez H."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
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        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
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        </location>
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        </location>
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        </location>
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        </location>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW77751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYC5</accession>
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                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
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                <person name="Gonthier P."/>
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                <person name="Hansson D."/>
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                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
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                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
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                <person name="Murat C."/>
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                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
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    <dbReference type="HOGENOM" id="CLU_033082_1_1_1"/>
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    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="14"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW77856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="347" mass="37888" checksum="80558372C77A5581" modified="2014-03-19" version="1" fragment="single">TDPSRHADLWFPDGSVVLRAENTLFCVHMSQLSRHSVVFRDMFSLPRSSASAHDLSANDLYEGCPLVRLHDLAEDVVNLLSALYDGPTFGSNDCSDFRIVSGILRLSNKYMIESLRAKAIAHLNIAWPMTLKGWDAREDKARAYELENIPGSAHLYPSPIAVINLARQVNASTLLPSAFYDLSRYTYTQIFESADDDQSRLRSFSPPLSSPHATPPPRAHPTSAPGPMLETTDLQKLALGKESASQAVSAVINGMTRGPYTHSRKSSLSRSSNPSSSSLSSGVCASPGACRRDFAELVALATQHYVCDRERGCADPLYVAEELGTLKSAELSECRACARGLEIWAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYN3</accession>
    <name>W4JYN3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chitin-binding type-4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_324730</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the polysaccharide monooxygenase AA13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548994.1">
        <property type="nucleotide sequence ID" value="XM_009550699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYN3"/>
    <dbReference type="STRING" id="747525.W4JYN3"/>
    <dbReference type="GeneID" id="20671073"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_324730"/>
    <dbReference type="eggNOG" id="ENOG502QQKA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053021_2_0_1"/>
    <dbReference type="InParanoid" id="W4JYN3"/>
    <dbReference type="OrthoDB" id="120613at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052282">
        <property type="entry name" value="Starch-active_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36575">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36575:SF2">
        <property type="entry name" value="CHITIN-BINDING TYPE-4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844174" description="Chitin-binding type-4 domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="8">
        <location>
            <begin position="20"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW78677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="192" mass="20708" checksum="71B21F5ABB84B34E" modified="2014-03-19" version="1">MDFFVKSIILAGFIGQALAHGVVTSPSPRKIGSAAKSACGTAVYSALASDKYGPIENAAKKIDDTYNAEACHLFFCKGYQYEDNAANTRVYTAGQVVNMQVDLAAHHTGHANVSVVNLSSQTTIGKPLYLWPVYANSSLGPSKWPTNETNFNVTIPDLGDECTTAGACAIQWWWYADSNGQTYESCVDFTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4JYY3</accession>
    <name>W4JYY3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_325003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550093.1">
        <property type="nucleotide sequence ID" value="XM_009551798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JYY3"/>
    <dbReference type="GeneID" id="20671099"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_325003"/>
    <dbReference type="HOGENOM" id="CLU_1886029_0_0_1"/>
    <dbReference type="InParanoid" id="W4JYY3"/>
    <dbReference type="OrthoDB" id="2792702at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW78091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="135" mass="15201" checksum="A9164A4D14B71D32" modified="2014-03-19" version="1">MCYMFKTRQTGMDRTDSMLYRLIVFAASRGLIMSCIRVVLTGDIRQFFVYNDKLYWAVFHFMLGKLCSNSVLASLNIRDFMRGDDSSNYSGSNSIALSPAFALRSGFGFRKVTACFVLCCNAPIRTDTHLVASLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZ14</accession>
    <name>W4JZ14_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_421062</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
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        </reaction>
    </comment>
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    <dbReference type="Proteomes" id="UP000030671">
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    <dbReference type="GO" id="GO:0005816">
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
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        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF417">
        <property type="entry name" value="CELL CYCLE PROTEIN KINASE DBF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
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    <dbReference type="PROSITE" id="PS50011">
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    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="128"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="441"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="157"/>
        </location>
        <ligand>
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        </ligand>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW78310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="537" mass="61500" checksum="C8DA04BBF3E21EFD" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0R5</accession>
    <name>W4K0R5_HETIT</name>
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        <recommendedName>
            <fullName evidence="4">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_104255</name>
    </gene>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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    </dbReference>
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            <end position="250"/>
        </location>
    </feature>
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        <location>
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            <end position="302"/>
        </location>
    </feature>
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        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="52692" checksum="76D313AD1753F79E" modified="2014-03-19" version="1">MSCDCTKSANSNWFPSQKVIDGYFEEPLGFPRVAVAGERDSYLPLNTLLAKALEVDGKGKLKPDLTGCLRKLKPMEKVPWREIEVGIEVKDDWLELLKQANTYGRSMLEEGSRWYALVIAVNHRTSEARFCWYTRLGLFLTPALDLTKKEGLTTFVGGIFGLAACDRERAGNDPCQVMLERTLHFLIPPPAPTFWRWSKTFCRRICVRGRATHVYRIGPAANLPEQIQERPEDGSGKEGQKEPWKRKGHNTKGIVQSWSWITYLVLFQRKRGMRYVQSPLGDVTGTQQPPSNTPEPSSHLTQVQKKTSDTAWCRLLGITPPTWTNVDVHWKESIDWSKMTSLVMKDSWPIESTAKVETEMFSQHYTAFFPFPSLPALANLIKLQPFLVTLSLPALIFSALTRMLTPLVRRMRLYVAGTDALASGCVCARGVLPDVLVFDSAVPQPDAPPKMYSSNSRPRADAPLPPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0T1</accession>
    <name>W4K0T1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_419149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009549694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0T1"/>
    <dbReference type="STRING" id="747525.W4K0T1"/>
    <dbReference type="GeneID" id="20673533"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_419149"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082492_1_0_1"/>
    <dbReference type="InParanoid" id="W4K0T1"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW79402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="282" mass="32143" checksum="9A3FF2E4168E0CDA" modified="2014-03-19" version="1">MLSRAAINSLISQLMAQCNGTIPIPIKNIYIRCYNGTRHPSYDVLTMVLKEMAACLDRTFIVLDSLDECTGLERTSLLQFLSQMKDWGLASLHTLVTDRSVLEIEDAIASQVDWRLDLQTEARFVDQDIQIYLDNLLSRDFSLRKWGAEEKAMISETLLERACGMFQWIRCQLDTLRMCVSYADLEAALVGLPKTLDATYERILQNILEDHQPRVYTVLQFLYFSASPMTLQVIAEVTIKEYSLTIARYEPRRRLCSPEDVLTLCGSLVSLSAKTVTRSMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4K135</accession>
    <name>W4K135_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_386970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549091.1">
        <property type="nucleotide sequence ID" value="XM_009550796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K135"/>
    <dbReference type="FunCoup" id="W4K135">
        <property type="interactions" value="231"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K135"/>
    <dbReference type="GeneID" id="20672300"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_386970"/>
    <dbReference type="eggNOG" id="KOG3914">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1063759_0_0_1"/>
    <dbReference type="InParanoid" id="W4K135"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036265">
        <property type="term" value="P:RNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028884">
        <property type="entry name" value="Trm82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288:SF0">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT WDR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288">
        <property type="entry name" value="WD40 REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW78781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="262" mass="29071" checksum="A9C2EDCDED9386CA" modified="2014-03-19" version="1" fragment="single">ANTSSYPHSKLLIGAEKCALISGPHIQILDTQSGQLLFSTASFEDSAKEAIVKSGPIRCAAVDEAFVHLATTGDDKKLKVWAVDGLRLLSERELPKKPTQVSFIRKGRFILVSDKFGDVFRYPLTPVPKQQPATESDVKRDPLASHENPSDGHLILGHTSLLTSFCLPSDEKYIITADRDEHIRVSWYPQGYCIENYCLGHEKYVSAIHIPAFLPSSLVSGGGDPALKIWDWQHGTVVCEIPVLEAIKPFIRVRAKKRKWGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1B6</accession>
    <name>W4K1B6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UDP-galactose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_124682</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549164.1">
        <property type="nucleotide sequence ID" value="XM_009550869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1B6"/>
    <dbReference type="FunCoup" id="W4K1B6">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K1B6"/>
    <dbReference type="GeneID" id="20666882"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_124682"/>
    <dbReference type="eggNOG" id="KOG1583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033007_1_1_1"/>
    <dbReference type="InParanoid" id="W4K1B6"/>
    <dbReference type="OrthoDB" id="999962at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005462">
        <property type="term" value="F:UDP-N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005464">
        <property type="term" value="F:UDP-xylose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF4">
        <property type="entry name" value="NUCLEOTIDE SUGAR TRANSPORTER SLC35B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW78871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="313" mass="34374" checksum="C07C93A941572FD4" modified="2014-03-19" version="1">MLSLVLGGCCTNVWAYERLLRIESRVGSALTFSQMLFITLQQLPSFITWKPSSGLLPRLKPRQVPLSQWLLQVVVLATGSLFNNWVYAFHVPLTIQIVFRSAGLAVSMLFGRFFMHKRYSIQQVTAVLLVSIGVVVATLSRPPSTDQSTDDLFEYALGVTMLTVSLALTGTLGMLQERTYQKYGPCWKEGVFYTHALSLPVFLFLIPQVKHGLGSLSEKSGSVVPMPYVILAANLVSQLVCVSGVNQLSSRVSSVSTQVVLTTRKAISLCFSVWWFGNGWNGQLGLGAGMVFVGSFWYTQIDADGRTGAGKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1K8</accession>
    <name>W4K1K8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_440755</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548255.1">
        <property type="nucleotide sequence ID" value="XM_009549960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1K8"/>
    <dbReference type="STRING" id="747525.W4K1K8"/>
    <dbReference type="GeneID" id="20675302"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_440755"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_27_1_1"/>
    <dbReference type="InParanoid" id="W4K1K8"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="19"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW79692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="502" mass="52809" checksum="CB5B61273118A6A4" modified="2014-03-19" version="1" fragment="single">MLDDAPLPPPVPRWRAWTLLLVFSMAQMLDIFNVTAPTVALPRIASDLDVLFTERQWAINAYSLTFGAFLLTGGRFSAIYGPKTLFVTGFTVVGVFSIVDGFSVDGPMLFVFRAIQGIGAALTIPSALTMITTLFPERGEQDRALGIFAGFGAMGNVSGLVIGGVIAELLTWRWIFWIMAMLILPLAFAAFLLAPPSSAAARGHASLRSMDWLGLGTITLALILLVYAITEGNNRGWATGGILAPLLVAVALLPAFALIETRVKEPLVPPLLEYLAMNVVIFQESLVFQQVWHTSALSAALRIIPFGITGFITTVSMGYVTPHVAPRWILCAGELLMMAGALLLAYAPTPDLYWSRVLPGIILTALGVSSGFVAANIEMLRTPLNRPASAARLRDSTALIGAIFNADLQIGSALGLAIATAITARVNGAPSAAATTTTSSSAAAANANGGAPLGSADFAGYRAAYWFLVGLTAAEAVVAGVFLRGRRRREGLIGEGGASGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4K274</accession>
    <name>W4K274_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Importin-95</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Karyopherin-95</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_459766</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the importin beta family. Importin beta-1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548438.1">
        <property type="nucleotide sequence ID" value="XM_009550143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K274"/>
    <dbReference type="FunCoup" id="W4K274">
        <property type="interactions" value="981"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K274"/>
    <dbReference type="GeneID" id="20677018"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_459766"/>
    <dbReference type="eggNOG" id="KOG1241">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008296_1_0_1"/>
    <dbReference type="InParanoid" id="W4K274"/>
    <dbReference type="OrthoDB" id="10263328at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000027">
        <property type="entry name" value="Importin subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="12">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="11">
        <location>
            <begin position="410"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00079884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW79902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="863" mass="94630" checksum="2828E762BDB4DD62" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2Y1</accession>
    <name>W4K2Y1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_322107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548003.1">
        <property type="nucleotide sequence ID" value="XM_009549708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2Y1"/>
    <dbReference type="GeneID" id="20670815"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_322107"/>
    <dbReference type="HOGENOM" id="CLU_046025_17_0_1"/>
    <dbReference type="InParanoid" id="W4K2Y1"/>
    <dbReference type="OrthoDB" id="2535105at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="100" mass="11588" checksum="F0610A00C678B6FF" modified="2014-03-19" version="1">MPSLIPLDNLLGVAFVGVIISTAQVVHHIYLIYGVTCLQLYLYYTKHCQYDGRFVKLFVSFFLSTFMVLDTLNLIFLAHAMYYYMVTNFGDYQALVPNVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4K329</accession>
    <name>W4K329_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_171370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548656.1">
        <property type="nucleotide sequence ID" value="XM_009550361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K329"/>
    <dbReference type="GeneID" id="20668335"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_171370"/>
    <dbReference type="HOGENOM" id="CLU_3087505_0_0_1"/>
    <dbReference type="InParanoid" id="W4K329"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW80139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="52" mass="5471" checksum="65D36C72E59D3CCE" modified="2014-03-19" version="1">MLAVNPNALLGCAGFIVDLKFPWMENVIGHSEVSKPAALKLGSTDTVMSVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4K352</accession>
    <name>W4K352_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_322539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548680.1">
        <property type="nucleotide sequence ID" value="XM_009550385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K352"/>
    <dbReference type="GeneID" id="20670869"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_322539"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181676_0_0_1"/>
    <dbReference type="InParanoid" id="W4K352"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="99" mass="10945" checksum="F3E691B4712DA9A8" modified="2014-03-19" version="1">MCGCGTEMNITAMWLGPGKHLKGRTWMGGVIMPEEFDYFHELIVYFELARCSMRAYMDELMAGMIFGLPPVLNFGLLAVQAAVVPDVLAGHKFICLAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4J0</accession>
    <name>W4K4J0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_171528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548488.1">
        <property type="nucleotide sequence ID" value="XM_009550193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K4J0"/>
    <dbReference type="GeneID" id="20668346"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_171528"/>
    <dbReference type="HOGENOM" id="CLU_2996737_0_0_1"/>
    <dbReference type="InParanoid" id="W4K4J0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="57" mass="6503" checksum="4B94AB82950DB252" modified="2014-03-19" version="1">MPRSVRVRSRASEVESLSVLRKGDCLRNCINKYENGLCKGAMAAMMRRIYIEPHCTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4K4N0</accession>
    <name>W4K4N0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial outer membrane protein OM14 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_445244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ETW80714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="747525.W4K4N0"/>
    <dbReference type="GeneID" id="20675615"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_445244"/>
    <dbReference type="eggNOG" id="ENOG502SCDT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW80714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="27494" checksum="3C8E852AC6C14C1D" modified="2014-03-19" version="1">MSYASVAAQDAPPLSEQPKPDPALLNTGSSRSDAVADDTSKVKVVPADFKDNLSTFTSETRETIVRDAEPAGDEARSHAHKAEAEGLHYWEVAKDHLLRPAIAGGLIGIVNIGLFAGASYAYYTHPPLRRDARAIASTVAVAVALLGGEGYAAEQFRQTPQGKKEERRAREEGSLVYRHAREHILRPGVLGGIVGLVNVGILGAVGYLAYTNWERPKWDRRAVSAISVGLMTLWSGEGFVAERYREGKIHPPRS</sequence>
</entry>
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    <accession>W4K5L6</accession>
    <name>W4K5L6_HETIT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_419033</name>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="20673520"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_419033"/>
    <dbReference type="eggNOG" id="KOG2213">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015163_0_0_1"/>
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    <dbReference type="OrthoDB" id="19224at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="329"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="539" mass="58650" checksum="B2D6A0F9AD2CC832" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5S6</accession>
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        <recommendedName>
            <fullName evidence="6">Hcy-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_476925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
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                <person name="Solheim H."/>
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                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
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            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="FunCoup" id="W4K5S6">
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    </dbReference>
    <dbReference type="STRING" id="747525.W4K5S6"/>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_476925"/>
    <dbReference type="eggNOG" id="KOG1579">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004914_3_2_1"/>
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    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008898">
        <property type="term" value="F:S-adenosylmethionine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HCY_dom"/>
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    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051486">
        <property type="entry name" value="Hcy_S-methyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015:SF1">
        <property type="entry name" value="HOMOCYSTEINE S-METHYLTRANSFERASE-LIKE ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="378"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW81119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="395" mass="43859" checksum="8325932F1D8D6B98" modified="2014-03-19" version="1">MAGFSEIFGSKKCCILDGGLGTTLEDIFHKNVSNTSLWSAKPIDEDPEIMIQTHLAFLRAGARVISTSTYQCAFETFEDAGYSRNDAARLMRKSVELAAEARSRYVDVANGIRRKDVKIALSLGPYGATLTPAQEFDGFYPLPFGPQEYSTSRPNRNTFTKEERAAGKATMAIDALTDFHLQRLRVFANDIDTWATIDCIAFETVPLVREITAIRGAMALLEEELKPRAQRFPWKPWWISTVWPEGRYPQSIRPDGVPMTVKDVVAFLLSSGSGELKHVAVGKTNVPDGLGINCTRMEHLSTIRMEMEAAVVDLKGEDAKPWFVVYPNGGETYDPVSRTWIKEEDPQHKSESWATGLGDLVDEARNSGVWDGVIVGGCCKTGPAEIQALSRRWEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5U5</accession>
    <name>W4K5U5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidoreductase AflY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_459590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547853.1">
        <property type="nucleotide sequence ID" value="XM_009549558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5U5"/>
    <dbReference type="GeneID" id="20677005"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_459590"/>
    <dbReference type="eggNOG" id="ENOG502S69W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019145_1_0_1"/>
    <dbReference type="InParanoid" id="W4K5U5"/>
    <dbReference type="OrthoDB" id="10004862at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="483"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW81188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="55527" checksum="782D91BFC2E1285E" modified="2014-03-19" version="1">MADTLPTGLPSTIHKDALTVSGASSHSKALVERLLEQDRESNHCFYGPGFHNHLSHHLLAAYDLGAPSSLIQAIYDEEKHGLNSVFTADRPNKTVERQNLHIGVDTWTHYLGQEKYYANYLEFFSDEVRRLGPKPAYQHYVFSEDANIGKAHMTERFVGGALHPLIQMGYAIEFGSDVMIAQALAQTAVHEAFEPGLFPWSSESVDDGPAVDISANGQRAATSKDEHTLLSILRETYRSDIMTPVLPYDPDALLSARRKAAFTPARVSEIRRLTMLWHLSAFATPAQLAQKTEELFFVAALLFAGVGRPGRKERLDFFLMHVLTSTVFVPNLVGALDGATAQKRLLEAVLSVVLAYVLLRGRPRIDCELIMSYTASPRPDGAQLIPTPGALGEPATKPDEYINPWPTLLAHVLPARDAHTLKALRTLYVGAQRYGTIPAGAVRGAVDSRGEETHAGAKRLDGSVFVRAAGALVRVMGWVGPGEGGGQKEGSWDRSALGWDEAWDEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6X9</accession>
    <name>W4K6X9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_439974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546228.1">
        <property type="nucleotide sequence ID" value="XM_009547933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6X9"/>
    <dbReference type="GeneID" id="20675213"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_439974"/>
    <dbReference type="eggNOG" id="ENOG502SMF9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020999_1_2_1"/>
    <dbReference type="InParanoid" id="W4K6X9"/>
    <dbReference type="OrthoDB" id="3341212at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="646" mass="72098" checksum="9A1041A21381DD66" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4K725</accession>
    <name>W4K725_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 monooxygenase 50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cyp50</name>
        <name evidence="10" type="ORF">HETIRDRAFT_62172</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546985.1">
        <property type="nucleotide sequence ID" value="XM_009548690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K725"/>
    <dbReference type="SMR" id="W4K725"/>
    <dbReference type="STRING" id="747525.W4K725"/>
    <dbReference type="GeneID" id="20678587"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_62172"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_3_1"/>
    <dbReference type="InParanoid" id="W4K725"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW81145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="510" mass="57238" checksum="D3A90BBF39D9967A" modified="2014-03-19" version="1">MDPLISAFSGLVLAVTLALFVYRRSPKSNLPFPPGPKPKFFSGNVDDIPKTYPWLGYAAMAKEYGPLIHLKVGMRRNMLVINSAQVASDLLESRSGIYSDRPKQWMYGVLANRLLNVFNISIQHSRFRRYRKLMNSGLNSRATQGYAPLMESEVKTLLRALYTKPEELSAHVRRNAGAVILKVAYGWEVKTNDDRFVTMMEKAVKMNVEANTPGKWLVEDLPALRYVPSWFPGAYFQRRARYFKEQLSQIDTVPFEWVKKQMASGSYIDSFTSRMLQPDDGNTPNAEEQDIIKWCSGALYAGGADTTVSALASFVAAMALYPEIQERARAEVDSVVGRDRLPTIEDVPHLHYVNAVVKEVLRWAPVAPMGLPHRLTQDDVYQGQFIPADTTVHANIWAILHDPALYPEPEKFNPERHLGEHPQPDPRKYAFGFSRRVCPGAHFAETSLTFTTSSVLSSLIISKKKDANGKVIEPIVEFTSSVTSHLKPSFQCDIVPRSAGARALIEDDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7D6</accession>
    <name>W4K7D6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_318229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546300.1">
        <property type="nucleotide sequence ID" value="XM_009548005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7D6"/>
    <dbReference type="GeneID" id="20670487"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_318229"/>
    <dbReference type="HOGENOM" id="CLU_050560_0_0_1"/>
    <dbReference type="InParanoid" id="W4K7D6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="479" mass="52572" checksum="532D49BF9FFFC2B3" modified="2014-03-19" version="1">MLLHDDHDASSPSRNSSPDVVLMVANPDVERVERGTSPHRPDAGRIDRGTSPQQPGPTGVLLTPHTNNFSDDDAEDYAKFKERERTRRPSPERASRGASRHESSDDRNQSSLGPLPVGVPPPSEGTRPSGVAGPSGFRARTAAQLPGHGEAEPIPVLSETAPPPIPTSGPIPSSMGGPTPRTDPHTGELERHADALLQRNTISAVIQMATAMALQRLANFSAGQPGNEHSDVPRRLASASLQIRALALQTDPDTASWYAHNDGRPRALLIHPDEFSQYVNRELLPALLFGGELGNVQPSRTDPFRVVTWNVPRPGEHPTPVPNPRRVPRTVVERPPPRQREVPTAHSHTATPPSHRIRGFPLSQGNTDEEEPPVYRRNEGRRSRGNQTTLGRGTTAGRSVRHRPGSPPPSARLRTDEREDNRSSRRTRRINSEARRNSSWTRSELDAWDALDDPGNYDDADPYYRPDEGGGDYQGPFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7E1</accession>
    <name>W4K7E1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_434166</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the wax synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546303.1">
        <property type="nucleotide sequence ID" value="XM_009548008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7E1"/>
    <dbReference type="GeneID" id="20674730"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_434166"/>
    <dbReference type="eggNOG" id="ENOG502SHW9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034105_1_0_1"/>
    <dbReference type="InParanoid" id="W4K7E1"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF57">
        <property type="entry name" value="OS04G0481900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="9">
        <location>
            <begin position="279"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW81679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="435" mass="48641" checksum="D963452A5C868B70" modified="2014-03-19" version="1">MGVTVYQELWYSASQAFRLLIPEPKARVPITWKTIPRTFIYFIPFVFLAYLARRPDTYLIRVLILPSLVSLALHCSFGYIWTDPRLNVYNWGSALCAFVVIAKSIDISLTANGRFKQGERTLGSMREPAVAAKADSDASADASARHRPGNSFLPVWLEDALELIFSIRGLGWDFGRGVHVPSHIRPTERGPFLRAAARSFITNFLMLDLLEALFKLIPGVGSVLGGSIFVSSFPPLQRYAFSTFIHFMTGCALLAGFNMVYDLLTLLAVVLLGHSPTAWPPIMDNPWISNSLHEFWAKRWHQTLRQTFLVFGGIPGRAIAGDLGLIFGTFLASGLYHECSIYAMGRGWDSRVPFFFLLQALALVGERVWRKVTGRRVGGFFGRLWVYFDVIVLGQPLVDAWHRRGLAGAMIIPPPISPARLLLLPAIRSLTGWQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7X9</accession>
    <name>W4K7X9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_384379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546522.1">
        <property type="nucleotide sequence ID" value="XM_009548227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7X9"/>
    <dbReference type="GeneID" id="20672197"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_384379"/>
    <dbReference type="HOGENOM" id="CLU_2184306_0_0_1"/>
    <dbReference type="InParanoid" id="W4K7X9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="109" mass="12294" checksum="F0B45BCC7828844A" modified="2014-03-19" version="1">MSVSFTRAIDSPTDCLPPRVVLAGINRCNTSGDRHPLESRRSFLYSPEKVTGQFSLLPVQCPISATRHLTRWEMCVCPRKERNRVNVLRMISTSSLIPYASLRSSSQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7Y4</accession>
    <name>W4K7Y4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_444964</name>
        <name evidence="4" type="ORF">HETIRDRAFT_444979</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546489.1">
        <property type="nucleotide sequence ID" value="XM_009548194.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546527.1">
        <property type="nucleotide sequence ID" value="XM_009548232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7Y4"/>
    <dbReference type="STRING" id="747525.W4K7Y4"/>
    <dbReference type="GeneID" id="20675606"/>
    <dbReference type="GeneID" id="20675607"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_444964"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_444979"/>
    <dbReference type="eggNOG" id="ENOG502S8B6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049061_0_0_1"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="12"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW81898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW81937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="386" mass="42461" checksum="3A4B6FC0A540FB72" modified="2014-03-19" version="1">MDSSPCVSFIGIVDFTENARWVFLTESVSDLLGYEPHELVGTPSLDLVHPDEFPQVKLLHYDTIRQDKAAVLAYLRMKHKDPYKGYILCAISRTVAHNVLVGSVSFAAMGPKAMHNASTAQEITIITPSATNFEFRRWNDPSPMPPSPIQVPLLDSLTDPGSPESTTESTADSSTSKETLKDVEDDKDEDAKDKGQDKGKSKEREVTPQPPVPKPEPITFDPLPKQSIRTALILDRFSLSCPIIYCSNDSFLSTTRIMGRSFFDFVIKRDEELVRSWIDAVKGWGVNERGQPSDGGFGFGKFTLSLVGRDSSDRHPDPPPSRHRHGQHGGPGARDSAARSHAHSAAPATARSRVRTRGSNQDQEMAVDSIFSAHSDGLMVILRHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4K806</accession>
    <name>W4K806_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_247964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546128.1">
        <property type="nucleotide sequence ID" value="XM_009547833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K806"/>
    <dbReference type="GeneID" id="20669213"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_247964"/>
    <dbReference type="HOGENOM" id="CLU_2549138_0_0_1"/>
    <dbReference type="InParanoid" id="W4K806"/>
    <dbReference type="OrthoDB" id="3270181at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="83" mass="8804" checksum="18EAA1E7FEFD6330" modified="2014-03-19" version="1" fragment="single">DEEDEQARRQRITAKLAGMGGMRFGMIPGASPVPNHPSPAPKREEPTPTIPSRAIPPAQLPPPPPSRSARPPIPTGRPPVPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8L1</accession>
    <name>W4K8L1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_247090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546046.1">
        <property type="nucleotide sequence ID" value="XM_009547751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8L1"/>
    <dbReference type="GeneID" id="20669144"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_247090"/>
    <dbReference type="HOGENOM" id="CLU_040578_2_1_1"/>
    <dbReference type="InParanoid" id="W4K8L1"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF1">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW81396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="15004" checksum="52A5775D721ADB31" modified="2014-03-19" version="1" fragment="single">EAKEALAGVAQLFGQHNTDGIDLYFLNNTKIQDVLAGNTPTGARLRDILNTYISQLEDRTVSHKPISIVVITDGAPDNKKELEDTIVSAASRLNQSHINSRELGIQFVQIGKDTGAEEYLKHLDNDLRGQYKIDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4K958</accession>
    <name>W4K958_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_314784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544732.1">
        <property type="nucleotide sequence ID" value="XM_009546437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K958"/>
    <dbReference type="GeneID" id="20670158"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_314784"/>
    <dbReference type="HOGENOM" id="CLU_2694487_0_0_1"/>
    <dbReference type="InParanoid" id="W4K958"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="92" mass="10604" checksum="2267149DB87AADA1" modified="2014-03-19" version="1" fragment="single">KCLVSLVGPFKGYILFCEVVERSGYGSEVSDESPIEVSKTEEGLYFFQVLRGWPGGDSLDLYRVHRYVIRRDNKPKVFDCVRFKGAFGRFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KA18</accession>
    <name>W4KA18_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_458443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544970.1">
        <property type="nucleotide sequence ID" value="XM_009546675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KA18"/>
    <dbReference type="GeneID" id="20676911"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_458443"/>
    <dbReference type="HOGENOM" id="CLU_605591_0_0_1"/>
    <dbReference type="InParanoid" id="W4KA18"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="452" mass="48197" checksum="F9BCBD9A39957E27" modified="2014-03-19" version="1">MTFLTTGQATDSLRLPGSLYVRARLQLHLLSALVAPLSLSLALRHRFLLWKMYQEVSNAEQAVYKTISTANPPARRRALANVGNALSLEQPRVRACIGRQKRHTLLPSSTRTAPSHPTAHSTTRKAPTPIPLKPRLTRVPTASNPPSHPAPIRAAGGPTRTTQPNRQQDGSDAQALENRTGALKPERNAPRLIVQRGRGAPYTTTHPARTSARRLSLPHNAALPLPLREQRPVDRALAARDMWPAGPARRAQGELDRLSVEQQLPTPPSSMRVRGPGVHALLSGAAASQPVSLSSPPLPPPPPPPPPPSAGMATSLVSLMRSLSGQRNSARGGTEDGWNAEGAGCSFTMELDETNKETLLGLTLSGLGAPAYPASPDVDSDFTPLAGDRGTEWSAGKLEAVRRIEAVGVGGGAAFAARDEVERAMEKVCEACLRLCKEWEALDALLGRADVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAH1</accession>
    <name>W4KAH1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_314805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545076.1">
        <property type="nucleotide sequence ID" value="XM_009546781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAH1"/>
    <dbReference type="FunCoup" id="W4KAH1">
        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KAH1"/>
    <dbReference type="GeneID" id="20670159"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_314805"/>
    <dbReference type="eggNOG" id="KOG3429">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089470_0_1_1"/>
    <dbReference type="InParanoid" id="W4KAH1"/>
    <dbReference type="OrthoDB" id="270639at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016150">
        <property type="term" value="F:translation release factor activity, codon nonspecific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052104">
        <property type="entry name" value="Mito_Release_Factor_mL62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075:SF54">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110916">
        <property type="entry name" value="Peptidyl-tRNA hydrolase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="2">
        <location>
            <begin position="45"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW82749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="184" mass="21159" checksum="18E1AF830B9FAA30" modified="2014-03-19" version="1">MGCSVTRRGVRTDSSPLPLPPSLDRLESAQDTAHARHWLMRFKSHKIPKDSVEITFSRSSGPGGQNVNKVNTKATLRCLLDSEWIPRWARAGLRKSPYFVSSSRSILIKSMAHRSQAQNIDDCLSKLHSLISSISSVDMRNEPSEKQKERVRSFERAERAKRRQEKDRRSQVKRDRSSSRKDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAM0</accession>
    <name>W4KAM0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_18343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">TC 32-1</strain>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
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        <property type="entry name" value="LDOC1 RELATED"/>
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    </dbReference>
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        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="9963" checksum="DFF96FEBF8B17B6C" modified="2014-03-19" version="1" fragment="single">DHTIDLKPIFKPQVPRIYALSPEKHNKLGKFIKEHLTRGTIHQSTSQNAAPFFFIEKKDGKLWPVQDYRYLNSRTILNVCLFPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAX7</accession>
    <name>W4KAX7_HETIT</name>
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        <recommendedName>
            <fullName evidence="7">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_434403</name>
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    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="ETW82226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009548473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAX7"/>
    <dbReference type="STRING" id="747525.W4KAX7"/>
    <dbReference type="GeneID" id="20674745"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_434403"/>
    <dbReference type="eggNOG" id="KOG1396">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011244_0_0_1"/>
    <dbReference type="InParanoid" id="W4KAX7"/>
    <dbReference type="OrthoDB" id="266334at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844116" description="SUN domain-containing protein" evidence="6">
        <location>
            <begin position="26"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="7">
        <location>
            <begin position="131"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="325"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="398"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="635"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="677"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="852"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="899"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="451"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="466"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="635"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="717"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="745"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="916"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW82226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="958" mass="100826" checksum="9B329D6B9F188D47" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAZ1</accession>
    <name>W4KAZ1_HETIT</name>
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        <recommendedName>
            <fullName evidence="1">Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_315947</name>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="20670274"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_315947"/>
    <dbReference type="eggNOG" id="KOG0143">
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    <dbReference type="HOGENOM" id="CLU_010119_10_2_1"/>
    <dbReference type="InParanoid" id="W4KAZ1"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="1">
        <location>
            <begin position="175"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="308" mass="35287" checksum="7F3CE59BE83F7A61" modified="2014-03-19" version="1">MSLLQVELEEKKQYETDIKKTGTFLGYKLPQYWHIANGVKDRIEHYRLNRNVDSTVHPVPLRPFLPEIQSFIKFNHIDVGQELLGLLALGLELPEDALVKKFSYEEKNNANCEFRNIYPHPKDEEIQTEGVWLKGHTDQGLLTILWSQPVSALQIRDEDGKWRWVRHVENALVCLHVQATGGFRSDKPTPHFSQIVNCGDSLEMLSGDYYKSAIHRVVQPPEDQQGYNRLGVFYFGYADDDVQLEPLTESPVLQRVGFTRHAPEGKAPFMGDWRKARAAAYGTSNLQKGEEEGIEEEVVGGIRVKHYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4KB59</accession>
    <name>W4KB59_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_54992</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544662.1">
        <property type="nucleotide sequence ID" value="XM_009546367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KB59"/>
    <dbReference type="FunCoup" id="W4KB59">
        <property type="interactions" value="437"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KB59"/>
    <dbReference type="GeneID" id="20678324"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_54992"/>
    <dbReference type="eggNOG" id="KOG2881">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040186_0_0_1"/>
    <dbReference type="InParanoid" id="W4KB59"/>
    <dbReference type="OrthoDB" id="442680at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015085">
        <property type="term" value="F:calcium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032468">
        <property type="term" value="P:Golgi calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032472">
        <property type="term" value="P:Golgi calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="GDT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049555">
        <property type="entry name" value="GDT1-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN HTP-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="GDT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01214">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW82964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="274" mass="29160" checksum="0F5F222CEF1B3FC6" modified="2014-03-19" version="1">MNDGTVPPVEGRAEAFVQAFAMIIFSEIGDKTFLIAAILAMRHPRSVVFAGAFGSLVVMSILSAALGHILPSLIPKRWTQAVAAVLFLAFGVKMFLEGRAMSGGNEEIQEEMREAEEEIEGDEAEHDGTGRVENGGSVIPLEEIEEGGRAANGPVSNSPLRQTVQGVRNLCSYILGPVFVQAFALTFLGEWGDRSQIATIVLAAAHNVYLVTIGTIIGHSCCTALAVVAGRYVATKISAKHVTLGGAALFLCFGVIYIYSAYQMTDVEMHIPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBE3</accession>
    <name>W4KBE3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_144228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545402.1">
        <property type="nucleotide sequence ID" value="XM_009547107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBE3"/>
    <dbReference type="GeneID" id="20667042"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_144228"/>
    <dbReference type="HOGENOM" id="CLU_2855881_0_0_1"/>
    <dbReference type="InParanoid" id="W4KBE3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW83118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="65" mass="7133" checksum="2D4AE0E03ADF7864" modified="2014-03-19" version="1" fragment="single">MFDVRTSEQPACPPWQPGNFEGACFNVVTAVEAPARPCQLRPVKSGYGVMAESGHRKTPRTLMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBU8</accession>
    <name>W4KBU8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_450934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545599.1">
        <property type="nucleotide sequence ID" value="XM_009547304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBU8"/>
    <dbReference type="GeneID" id="20676094"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_450934"/>
    <dbReference type="HOGENOM" id="CLU_1428164_0_0_1"/>
    <dbReference type="InParanoid" id="W4KBU8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="190" mass="21796" checksum="0417B9E76644C0BE" modified="2014-03-19" version="1">MHLLKRPSFQPFWRPLRRPSEHSAFQLPYPYLIGHPRPVFNTVVPPLRSSYKRKDRRKDRRQTPPSCPSCDRPLPPSRAFRHGSESHYLGRVVVPSKASGVARILSRGDGLESSSTQTQTQTQIQTQTQTQTQTQTRYFWISLSSLVARVHRTAHANDDVPSLPARIEPAGPSRRRHVVQRARRLPGRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCK3</accession>
    <name>W4KCK3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Macrofage activating glycoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_316292</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545715.1">
        <property type="nucleotide sequence ID" value="XM_009547420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCK3"/>
    <dbReference type="STRING" id="747525.W4KCK3"/>
    <dbReference type="GeneID" id="20670314"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_316292"/>
    <dbReference type="eggNOG" id="ENOG502R3Y3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036093_2_1_1"/>
    <dbReference type="InParanoid" id="W4KCK3"/>
    <dbReference type="OrthoDB" id="2564904at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845304" description="Macrofage activating glycoprotein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW83469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="39391" checksum="FC6A0EFB32C7A16C" modified="2014-03-19" version="1">MVHYALSALLAVASSTYVVAQSATEQQFPDTPLANKHFSYPTQIPYKSDTDSFGRGTQFGYNLCNSTTEGASSLCQTSFVNHLDDFCLWSPASPNSTIADTEGEEVAWCTKKGHGTRLMPAGTLQGVQYLKTPDYILIAGFIDQTKINIQDGDYGGELDPHGQDLRGNPLGGLLYSNVFETNNDNNTYTQVIEWTNFMGGNAFCIKACDPAGANAASYCQHIYDRIGCSYNAPNNAQNGTFEVCDSDNMMFPGQYVENGVTMTYTQPPESLGAITTMPYTASIPASSNCRTFQSADLYTDLAAVTASAASSAATATATASGKSGSSASASKGSSASGTASRSGSASSATVTGASSGASSMGVSLVAGIVGVAFSVVALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCQ5</accession>
    <name>W4KCQ5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_407987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543308.1">
        <property type="nucleotide sequence ID" value="XM_009545013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCQ5"/>
    <dbReference type="GeneID" id="20672648"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_407987"/>
    <dbReference type="HOGENOM" id="CLU_3068939_0_0_1"/>
    <dbReference type="InParanoid" id="W4KCQ5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="53" mass="5770" checksum="BC5CE6D3AE3E188C" modified="2014-03-19" version="1">MGAEQSFKENGADADVVDVDEKRETRGDGRGCGKSVEWVPGVLQLQIMKSKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDB5</accession>
    <name>W4KDB5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_432845</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543502.1">
        <property type="nucleotide sequence ID" value="XM_009545207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDB5"/>
    <dbReference type="STRING" id="747525.W4KDB5"/>
    <dbReference type="GeneID" id="20674636"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_432845"/>
    <dbReference type="eggNOG" id="KOG4245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039329_4_0_1"/>
    <dbReference type="InParanoid" id="W4KDB5"/>
    <dbReference type="OrthoDB" id="191270at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF28">
        <property type="entry name" value="ISO-OROTATE DECARBOXYLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="5">
        <location>
            <begin position="8"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW83749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="398" mass="42212" checksum="F815D71530DB9032" modified="2014-03-19" version="1">MALSRLVVDIHTHVYLPRYASVLRSRTAAPRILSRTTPAGLAEDRLVILDDEPSGGRPVGPQYWDRDEKLKFMDNHGIDISIVSTANPWLDFLPFPAAQTLARDLNADLESYCSTAPPADPSAPALKRLYGFGLLPLVPGTPPAALPPAVAHLAASHPHIRGVILGTRAAGKGLDDPALEPLWAALADSGLVVFLHPHYGLGPQAWGDADNGHVLPLALGFPFETTTAITRLILAGVLDRHPRLRILLAHAGGALPQLSSRLASCIAHDPAVAARLRHDARWYLGRLYFDAVAYGSAELAFVADAVGRAARFASATGAPDKADTAPEGEGAGAGERNAGSRRMLFGTDHPFFPPLDESERWRSVVENLEAIDGVAGWSAADRAGVKGANALELFGLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDH4</accession>
    <name>W4KDH4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor Cactin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_170300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
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            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CACTIN family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="interactions" value="666"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KDH4"/>
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    <dbReference type="eggNOG" id="KOG2370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011759_2_1_1"/>
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    <dbReference type="OrthoDB" id="265955at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019134">
        <property type="entry name" value="Cactin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018816">
        <property type="entry name" value="Cactin_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737">
        <property type="entry name" value="POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737:SF4">
        <property type="entry name" value="SPLICING FACTOR CACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10312">
        <property type="entry name" value="Cactin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CactinC_cactus"/>
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    </dbReference>
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        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Splicing factor cactin central" evidence="5">
        <location>
            <begin position="3"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Splicing factor Cactin C-terminal" evidence="4">
        <location>
            <begin position="359"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09732"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF10312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW83838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="483" mass="56037" checksum="2BF6633A815312CA" modified="2014-03-19" version="1">MHRMAESAQMADWIAKDGDFQLEQERRRAAIRIREKRAKAVDFLALNLRYVNPIDEAEDEVGIEEAGLEIDLDEPYNIFDSLSPDQVDELHDDIERYLQLEQSDVNIDFWTNMMVICKDRVERIKADQRLGVEASAAVESDITALLQGKPYDHLVALQRQIQAKLSSGEPVDTDYWESLLKKLLVWKAKARLKSLHEVVVRNRLEQLRKRQRDEALQAQEELLEGVANAAAGKAHAAVVEPTVVQESVLAEDVEPYDRAMSPGLIDITKLPYEERQIDIVLEADDRRALLEQRRAVAASRFVPKAAQPAPQEEEDIEAPSGADLASEALYRAEAEKDMDEEEELFNLEENIVNPTTYNWEDKYRPRKPRYFNRVHTGYEWNKYNQTHYDTDNPPPKVVQGYKFNIFYPDLIDKSKAPSYKIVKEPGNDDTVLLHFTAGPPYEDIAFRIVNREWEYSHKRGFRSSFDRGCLSLWFNFRRNFYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEK5</accession>
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            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009545208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEK5"/>
    <dbReference type="GeneID" id="20675944"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_449402"/>
    <dbReference type="eggNOG" id="ENOG502R2KH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_513928_0_0_1"/>
    <dbReference type="InParanoid" id="W4KEK5"/>
    <dbReference type="OrthoDB" id="2985494at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="377"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="91"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW83750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="530" mass="56827" checksum="8E3D1111800F8CCA" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEP3</accession>
    <name>W4KEP3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADP-ribosylation factor-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_123919</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
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                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the small GTPase superfamily. Arf family.</text>
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        <property type="protein sequence ID" value="ETW84293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009545683.1"/>
    </dbReference>
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    <dbReference type="STRING" id="747525.W4KEP3"/>
    <dbReference type="GeneID" id="20666847"/>
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    <dbReference type="eggNOG" id="KOG0072">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_9_3_1"/>
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    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04151">
        <property type="entry name" value="Arl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000306">
        <property type="entry name" value="ADP-ribosylation factor-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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    <feature type="binding site" evidence="7">
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            <position position="76"/>
        </location>
        <ligand>
            <name>GTP</name>
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            <begin position="132"/>
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        <ligand>
            <name>GTP</name>
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        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW84293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="187" mass="20768" checksum="658232D064CF0831" modified="2014-03-19" version="1">MGLSVSSLFTSFASLLRWSKDQDVRILMLGLDSAGKTTILYRLQIGEVVSTIPTIGFNVETVEYKNIKFQVWDLGGQSSIRPYWRCYFPNTSAIIYVIDSSDHDRLQTSRSELLTMLSEEELAGVPLLVFCNKQDVDGALKPEEVSEKLGLAGGEKGRDWSVRGSCAVKGEGLEEGLDWLVNAIQKK</sequence>
</entry>
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    <accession>W4KGA1</accession>
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        <name evidence="2" type="ORF">HETIRDRAFT_449828</name>
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            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
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                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
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                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="747525.W4KGA1"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
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        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="321" mass="33960" checksum="02B86DE78D714B26" modified="2014-03-19" version="1">MRREDRGGDGREGATERPHRPARLALGAEATVGNSPTPANKIHPLTSTRVLSLSHRPQPSSVPSITPRGPPPPPIKPPRAPPPSVPSRHAPPAFPSTLPTHPRTHAPTHPPCPAQPPFYSRPLPNPASPFPLVPLDRPTTLSGVETVHANGAVSRAPPFAIHRSIHLPPPSEPALLFFPPSQNGPRHALFPTPAQIAICTQPEPALAAARPARTCPQPLPSNPPLSLAPLPTASIPRSSHLATATRPSRTTPPPSPSHPSFRPLLPDRLLPAQARRPPPTSPNTNIALFGRPDTSPASSLSPITGPSPPSSRIPTYHVHLH</sequence>
</entry>
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    <name>W4KGE6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">HETIRDRAFT_408749</name>
    </gene>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Durling M."/>
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                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
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                <person name="Hietala A."/>
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                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544559.1">
        <property type="nucleotide sequence ID" value="XM_009546264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGE6"/>
    <dbReference type="GeneID" id="20672711"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_408749"/>
    <dbReference type="HOGENOM" id="CLU_3106632_0_0_1"/>
    <dbReference type="InParanoid" id="W4KGE6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW84938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="51" mass="5355" checksum="3B35E04CFE54B7FD" modified="2014-03-19" version="1">MATTGNDHACHSANVIGVCLSGPRYSRWTQIGTNLGDRCIACTTPSPSVPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGH8</accession>
    <name>W4KGH8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_416444</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544433.1">
        <property type="nucleotide sequence ID" value="XM_009546138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGH8"/>
    <dbReference type="GeneID" id="20673320"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_416444"/>
    <dbReference type="HOGENOM" id="CLU_3125236_0_0_1"/>
    <dbReference type="InParanoid" id="W4KGH8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW84804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="50" mass="5929" checksum="ED689100F843AEBB" modified="2014-03-19" version="1">MIIRHSISIVYLSTKFETILVILEWRYRVDMGPMNQKLGAEEGFVYRPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGK5</accession>
    <name>W4KGK5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_408715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544462.1">
        <property type="nucleotide sequence ID" value="XM_009546167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGK5"/>
    <dbReference type="GeneID" id="20672703"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_408715"/>
    <dbReference type="HOGENOM" id="CLU_2512901_0_0_1"/>
    <dbReference type="InParanoid" id="W4KGK5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW84834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="85" mass="9270" checksum="C3DB44AEA9016B55" modified="2014-03-19" version="1">MPDVTSKVPPPVEQEQFGSPVLLRSEWIPSAAECRDAAHSSTSLTVSIRADIGMAGPLGVRGLHSLMLFLAICRPVLPRSTWHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGR0</accession>
    <name>W4KGR0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-ribosomal peptide synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_444247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544164.1">
        <property type="nucleotide sequence ID" value="XM_009545869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGR0"/>
    <dbReference type="GeneID" id="20675571"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_444247"/>
    <dbReference type="eggNOG" id="ENOG502QWJ3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005562_3_0_1"/>
    <dbReference type="InParanoid" id="W4KGR0"/>
    <dbReference type="OrthoDB" id="3142841at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF5">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01222)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="54510" checksum="A3CB7AA19F76FADD" modified="2014-03-19" version="1">MTDMEKTVTPPAPTYQGQIHIADVPALPHTPVDSSRLSPSYSSASVLEKGNVWDGYLEDDIPDKTQGRLIRNLRHQIFSLYRRLFGVIFVTNMAVFIATLVRDEANPSHLALIVVANLFCAILMRQDHVINTFFNVFCAVPSSWPLVIRRVCARVYSIGGFHSGCGVSGVVWFILFIVQATREVVNGGPTSVATLIISYLILLLLLGIVALAYPRLRILYHNSFEATHRFLGWTAVALVWCQVILLTNDHRPEGQTLGKALIKTAPFWMVLVMSISIILPWLKLRKVAVRSEVLSNHAVRLYFDYVTPVPGSFTRVSTDPLMEWHGFATIAEPGKKGYSMVVSKAGDWTSKQIANPPEKIWIRGVPTCGVMRIVPIFRRVILVATGSGIGPIAPHVFARPIPLRLIWTAPNVRQTFGDKLVDSILEAAPDTVIFDTRVHGKPDMVKLTYRLVREFNAEAVCIISNQALTRKVVYGMMSRGIPAFGAIWDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGT1</accession>
    <name>W4KGT1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_18523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543148.1">
        <property type="nucleotide sequence ID" value="XM_009544853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGT1"/>
    <dbReference type="STRING" id="747525.W4KGT1"/>
    <dbReference type="GeneID" id="20668619"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_18523"/>
    <dbReference type="HOGENOM" id="CLU_010591_6_2_1"/>
    <dbReference type="InParanoid" id="W4KGT1"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW84919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="92" mass="9266" checksum="4EABBF35BDA05348" modified="2014-03-19" version="1" fragment="single">SAFVLAHAACVPVAVSDRATRFRSQVAFVNQNKVGAACDNLPVGEVLCLGVVGQDCATTHTVVSGDFCASIAGAASTLLANNPNVSSDCSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGW2</accession>
    <name>W4KGW2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_101142</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541973.1">
        <property type="nucleotide sequence ID" value="XM_009543678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGW2"/>
    <dbReference type="GeneID" id="20665737"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_101142"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_8_0_1"/>
    <dbReference type="InParanoid" id="W4KGW2"/>
    <dbReference type="OrthoDB" id="3066029at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF64">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="37"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW85087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="470" mass="50531" checksum="042C2D9D70722F5A" modified="2014-03-19" version="1">MSTDSEQTPLLSARGDAAADKHDAVYNRFSRTRKRVIVALVSLAGLIPLFVAGAFIPSIPEIAREFNTTGSVVNMAVSLSLLASAIGTLTWANYSGFYGRRPIYLASLPFFTLGSLGVAQARSIPEIMIWRFVQAFGAGGGLSVGAGVIGDIYRLEERGGAMGVFFAACLLGPALAPLCGGLATHYASWRVMQLALFVTGVLVGTAMYFLLPETSQPHARGIDKLYEQQGTTQWRWVWLNPFKSLALFRSPNLLAVCLAGTFVLLTDYVMLLPLAYTIGQRYGITNEALIGAFFLPCGLGNIIGAPLAGRVSDIIVVRWRKRRGGEWVPEDRLRGTLYGACIFVPLSVLCSGLVTHYIGGTLGIVLNLVCLFFNGLGVDLVLSPSAAYNVDIMHSRSAEIMAANTGFRGAFISLATVGILPLINRVGVLPTNILSAAIAWMGCALLWATIRYGDRMRAWVDIGYSTADTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGZ9</accession>
    <name>W4KGZ9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_240237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543990.1">
        <property type="nucleotide sequence ID" value="XM_009545695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGZ9"/>
    <dbReference type="GeneID" id="20668849"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_240237"/>
    <dbReference type="eggNOG" id="ENOG502RZ9J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040908_6_2_1"/>
    <dbReference type="InParanoid" id="W4KGZ9"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="1">
        <location>
            <begin position="7"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="247" mass="27555" checksum="2173A1122C0543B8" modified="2014-03-19" version="1" fragment="single">NGSGKGGLAWPNGNQSSISSYVFADQFTITWRRSLYTWSPELPDNCWSLGFNCIPMLWGENQLEDFSKKVVKGYANIALGFNEPNESGQSNMTPDRGAELWKQYLAPLRSQGYQLGSPATSSNPNGFTWVQNFVSACNGGCEFDFVALHWYDVKATDFIAYVEKWHNGFNKPVMVTEYACQNFNGGAQCSKDDIFSFMSTVNSWMDSTDYVLAYFPFGVMGDMQGVNDLDRLMTSSGSPTDLGFLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4KH57</accession>
    <name>W4KH57_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Phosphoribosylaminoimidazole carboxylase</fullName>
            <ecNumber evidence="4 11">4.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HETIRDRAFT_313681</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2</text>
            <dbReference type="Rhea" id="RHEA:10792"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.21" evidence="4 11"/>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544298.1">
        <property type="nucleotide sequence ID" value="XM_009546003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KH57"/>
    <dbReference type="FunCoup" id="W4KH57">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KH57"/>
    <dbReference type="GeneID" id="20670052"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_313681"/>
    <dbReference type="eggNOG" id="KOG2835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011534_2_1_1"/>
    <dbReference type="InParanoid" id="W4KH57"/>
    <dbReference type="OrthoDB" id="15425at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000013">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000037">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016301">
        <property type="entry name" value="Ade2_fungi/plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054350">
        <property type="entry name" value="PurT/PurK_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004679">
        <property type="entry name" value="PRK06019.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609:SF5">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609">
        <property type="entry name" value="PURINE BIOSYNTHESIS PROTEIN 6/7, PUR6/7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22660">
        <property type="entry name" value="RS_preATP-grasp-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001340">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52255">
        <property type="entry name" value="N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="98"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW84660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="565" mass="60629" checksum="8FC1BB406E94E77B" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHB4</accession>
    <name>W4KHB4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Laccase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">lcc18</name>
        <name evidence="10" type="ORF">HETIRDRAFT_181231</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544352.1">
        <property type="nucleotide sequence ID" value="XM_009546057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHB4"/>
    <dbReference type="STRING" id="747525.W4KHB4"/>
    <dbReference type="GeneID" id="20668595"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_181231"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_2_1_1"/>
    <dbReference type="InParanoid" id="W4KHB4"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13903">
        <property type="entry name" value="CuRO_3_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF511">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="36"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="165"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="370"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW84715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="533" mass="59800" checksum="5CC6A196017D7D1D" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHQ8</accession>
    <name>W4KHQ8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_44016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541798.1">
        <property type="nucleotide sequence ID" value="XM_009543503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHQ8"/>
    <dbReference type="STRING" id="747525.W4KHQ8"/>
    <dbReference type="GeneID" id="20675233"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_44016"/>
    <dbReference type="eggNOG" id="ENOG502S3G3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_32_0_1"/>
    <dbReference type="InParanoid" id="W4KHQ8"/>
    <dbReference type="OrthoDB" id="128646at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="110" mass="12817" checksum="6E72C43B2AE58308" modified="2014-03-19" version="1">MKVSNRYQNAGAKATINSACEGVIVNETWVRRHRFPTYTLNNPIRVRNVDDTINKAGLIRSALDVNLIIWDIHRQTHTERVQMFISNLGKDDLILGTDWLKYHDPSIEWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KHS4</accession>
    <name>W4KHS4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_311073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542251.1">
        <property type="nucleotide sequence ID" value="XM_009543956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KHS4"/>
    <dbReference type="GeneID" id="20669831"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_311073"/>
    <dbReference type="eggNOG" id="ENOG502SW6N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190138_1_1_1"/>
    <dbReference type="InParanoid" id="W4KHS4"/>
    <dbReference type="OrthoDB" id="3169417at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="59" mass="6661" checksum="F35A8DD4E423DA2A" modified="2014-03-19" version="1">MQNRLLAVGAHTTYTVPFGVTYEKIGTIQRRLAWPLHKDDTLSQSGRPTGLNIYFVLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIV3</accession>
    <name>W4KIV3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_310118</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542480.1">
        <property type="nucleotide sequence ID" value="XM_009544185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIV3"/>
    <dbReference type="STRING" id="747525.W4KIV3"/>
    <dbReference type="GeneID" id="20669750"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_310118"/>
    <dbReference type="eggNOG" id="KOG4299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013898_0_0_1"/>
    <dbReference type="InParanoid" id="W4KIV3"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15535">
        <property type="entry name" value="PHD1_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15534">
        <property type="entry name" value="PHD2_PHF12_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052819">
        <property type="entry name" value="Chromatin_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="220"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="18"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="154"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="598"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="746"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="844"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="624"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="673"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="705"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="760"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="772"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="844"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="911"/>
            <end position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW85644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="947" mass="102795" checksum="25C13163FC56E2AC" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJA3</accession>
    <name>W4KJA3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Postreplication repair E3 ubiquitin-protein ligase RAD18</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Postreplication repair E3 ubiquitin-protein ligase rad18</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 18">RING-type E3 ubiquitin transferase RAD18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">HETIRDRAFT_424703</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 27">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RAD18 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542259.1">
        <property type="nucleotide sequence ID" value="XM_009543964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJA3"/>
    <dbReference type="FunCoup" id="W4KJA3">
        <property type="interactions" value="170"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KJA3"/>
    <dbReference type="GeneID" id="20674001"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_424703"/>
    <dbReference type="eggNOG" id="KOG0287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028491_3_0_1"/>
    <dbReference type="InParanoid" id="W4KJA3"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097505">
        <property type="term" value="C:Rad6-Rad18 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
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        <location>
            <begin position="38"/>
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        </location>
    </feature>
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        </location>
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        <location>
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        </location>
    </feature>
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            <begin position="109"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
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            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
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            <begin position="222"/>
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        </location>
    </feature>
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            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="366"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
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        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
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            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51908"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW85395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="410" mass="45315" checksum="08769D7D3C6339F7" modified="2014-03-19" version="1">MVNNNVGDLLKSDIQDPSDFPPHSVAPGLRELDSALRCKICSELYEAPVILACGHCFCSLCVRCAMADKAECPTCRKPANDTQLRANMYMEEVVVAWNKARSFVLHWSKEEESRSQQSSDNTALESGTRPAKRRKLSSERFVGSSDVERLGSEDELLRSNFTAERSKAKIRHRNHNNLVTSNGEPSSSSRPADVPLVDCPVCAKQVPFSVINQHIDGGCRLSPTPNSVSSPQMKSKTAQKTAWSKILNGVPADKGNSKGKGKASAKASGSDMSPLPKVSYTVLKDKQIRDLLAQSGLSISGERNVLIARHQRWVYVYNANLDRGEQHRKRVSELRASMKQWDERHNDQKKGGKEIVKDVVQHQKQNKAHFNALIEQARPKAPDKTPPTNLPVSEPVGSSNDLKEGDQLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJD5</accession>
    <name>W4KJD5_HETIT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">HETIRDRAFT_310101</name>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_009543761.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_310101"/>
    <dbReference type="HOGENOM" id="CLU_621211_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJD5"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="115"/>
        </location>
    </feature>
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            <end position="264"/>
        </location>
    </feature>
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            <end position="292"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW85181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="441" mass="48465" checksum="3C984BD7468E0F6C" modified="2014-03-19" version="1">MSLAVVCSLLAIFSGLSMFPGRSVSSSLLAVSWIWCARSVLLAPRSPLYPCSVFSPGCVFFLLTLSFSLCLSWSSLSPLAVALLLVSGFSSQSLLVYLSLVSFLVYLVWPSFILGGPGLSRRRSRPLSSRTATHAYFKLQELAPRPYVLHFQYSLPPHVHRTVEAQSRILWHDRLKHDVRLIAGTIAFKHDSKFLGCSVSSGDTTLGSVALVCGIGLYRSLEVASTSGCWYLWNVSGSCPLARLLTGGFRLLLLFAALYCPWLWSTRSSLCSLVALCFLCCLLAVSFLLALAPSLCSTSFSLSPSLAVALLLISGFSSQSFLVYLSLVSLLVYLLWPSFILGGPGLSRRRSRSVMFISFLLIVLFWCISPTFSPHPWSRISCQYSESPTRLTFTVSQQVHRTVGAQHWVIIGTISLKHDLKFTRRNNQRSSVTSTSGILAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KJM8</accession>
    <name>W4KJM8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_438586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542845.1">
        <property type="nucleotide sequence ID" value="XM_009544550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KJM8"/>
    <dbReference type="GeneID" id="20675058"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_438586"/>
    <dbReference type="HOGENOM" id="CLU_2126915_0_0_1"/>
    <dbReference type="InParanoid" id="W4KJM8"/>
    <dbReference type="OrthoDB" id="3250732at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="114" mass="12879" checksum="CAFFE190511F600E" modified="2014-03-19" version="1" fragment="single">MCGNRRKDPIHQHDIVCSLSSLPCKQCHRATCLRHLLSQGIHSSHAIIAVLRDKEHRHWHKGHRLLREAFPSAKKSILDAELSGDACSYIYGHRLALAAITFPKCQPVNPVFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4KK14</accession>
    <name>W4KK14_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_100276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542963.1">
        <property type="nucleotide sequence ID" value="XM_009544668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KK14"/>
    <dbReference type="GeneID" id="20665677"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_100276"/>
    <dbReference type="HOGENOM" id="CLU_2373049_0_0_1"/>
    <dbReference type="InParanoid" id="W4KK14"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="95" mass="10234" checksum="35EFC13D3FE49AA2" modified="2014-03-19" version="1">MVRAVVKGSSSPSGRYSCITALGPRISSSPDGRATNRQNITSRKLQQTRSEMFGTVPPNLRSVPPSYARFTHPRTIAFILSNETFLLPGAPASAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KK41</accession>
    <name>W4KK41_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_100250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542990.1">
        <property type="nucleotide sequence ID" value="XM_009544695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KK41"/>
    <dbReference type="GeneID" id="20665675"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_100250"/>
    <dbReference type="HOGENOM" id="CLU_2277860_0_0_1"/>
    <dbReference type="InParanoid" id="W4KK41"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="102" mass="10960" checksum="718E377844A5865A" modified="2014-03-19" version="1">MYHVRFRWAHRVKGNKGLGTYSGEDGVSAPFSSILGQGRVGYMTGGGQTGLGAYLLDANFTIHYGHPDCRLRAARIPGPVLCGPNSYFSPTCSLFLSQTAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKA9</accession>
    <name>W4KKA9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_407879</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542923.1">
        <property type="nucleotide sequence ID" value="XM_009544628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKA9"/>
    <dbReference type="GeneID" id="20672635"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_407879"/>
    <dbReference type="HOGENOM" id="CLU_1981851_0_0_1"/>
    <dbReference type="InParanoid" id="W4KKA9"/>
    <dbReference type="OrthoDB" id="5569309at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="72"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW86154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="126" mass="13154" checksum="39D3A52AB95186BB" modified="2014-03-19" version="1">MCHPPTPTQRNDAHAGGTPFQPNAARHIGWGAGGTERNAVAKGLEDDAQKGGAARDRDARRAIASTVFSGSLGTKAKAQLRDIASALGLPVEGTKKVVVERIQAHLDATPALADHPRFAGLRACRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKM0</accession>
    <name>W4KKM0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c oxidase assembly protein COX16, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cytochrome c oxidase assembly protein cox16, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">lep8</name>
        <name evidence="13" type="ORF">HETIRDRAFT_44056</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COX16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541800.1">
        <property type="nucleotide sequence ID" value="XM_009543505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKM0"/>
    <dbReference type="FunCoup" id="W4KKM0">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KKM0"/>
    <dbReference type="GeneID" id="20675275"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_44056"/>
    <dbReference type="eggNOG" id="ENOG502S9GT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131611_2_0_1"/>
    <dbReference type="InParanoid" id="W4KKM0"/>
    <dbReference type="OrthoDB" id="5516033at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020164">
        <property type="entry name" value="Cyt_c_Oxase_assmbl_COX16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130:SF14">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX16 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14138">
        <property type="entry name" value="COX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW86362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="116" mass="13182" checksum="866F633025D9BAFF" modified="2014-03-19" version="1">MPTFRSNALNQSAVARAVRRSPLLFGIPFVSLIVGTSFGLQAFTQTRYDLHSQKVTQLTKEQALGLDRNRKKFDIREEYFNLSAAGDAEWEPKRIPRPKGLPEWGVPPEEQPDAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKM8</accession>
    <name>W4KKM8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pumilio homology domain family member 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_471122</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PUF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542703.1">
        <property type="nucleotide sequence ID" value="XM_009544408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKM8"/>
    <dbReference type="STRING" id="747525.W4KKM8"/>
    <dbReference type="GeneID" id="20677382"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_471122"/>
    <dbReference type="eggNOG" id="KOG1488">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004017_8_1_1"/>
    <dbReference type="InParanoid" id="W4KKM8"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000004">
        <property type="entry name" value="Pumilio homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="8">
        <location>
            <begin position="19"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="39"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="75"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="112"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="183"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="219"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="255"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="7">
        <location>
            <begin position="291"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00081811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW85895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="385" mass="44231" checksum="506B6D7EE7B3F394" modified="2014-03-19" version="1">MYQQGIHSGRRREGDNPALRSPILDEFRANKSRKWELRDIFGYIVEFSGDQHGSRFIQQKLETATSEEKQIVFDEIVPDNTLQLIQDVFGNYVIQKLFEHGTQVQKTVLANAMETHILPLSLQMYGCRVVQKAVEFVLPEQQGSFVKELEPHVLKCVKDANGNHVIQKLIERVSPDRLAFVNSFRGNVYELSTHPYGCRVLQRCFEHLSEEQTRPLLDELHKYTINLMQDQFGNYVIQFVLEHGKPQDRALIISKLRGQMLHMSRHKFASNVCEKALVTADSQSRRQLIDEIITPKQDGVSPIVTMMKDQFANYVLQRALSVVEGDQKEELVSKIKPQLVSMRRYSSAYSKHLIAIERLLEKTLGSKVNEDFLSATLEATNLSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4KL09</accession>
    <name>W4KL09_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar complex-associated protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_432559</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542825.1">
        <property type="nucleotide sequence ID" value="XM_009544530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KL09"/>
    <dbReference type="FunCoup" id="W4KL09">
        <property type="interactions" value="535"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KL09"/>
    <dbReference type="GeneID" id="20674618"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_432559"/>
    <dbReference type="eggNOG" id="KOG2153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012441_0_0_1"/>
    <dbReference type="InParanoid" id="W4KL09"/>
    <dbReference type="OrthoDB" id="10263597at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011501">
        <property type="entry name" value="Noc3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016903">
        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428:SF5">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Nucleolar_complex_p3"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
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        <location>
            <begin position="270"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="CCAAT-binding factor" evidence="7">
        <location>
            <begin position="630"/>
            <end position="807"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="526"/>
        </location>
    </feature>
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        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
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        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR028977"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07540"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW86040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="817" mass="90651" checksum="F84C74B798E9096D" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KL62</accession>
    <name>W4KL62_HETIT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_437457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_437457"/>
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    <dbReference type="InParanoid" id="W4KL62"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
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        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
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        <location>
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            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="83" mass="9582" checksum="37C3B147AA7B8E7B" modified="2014-03-19" version="1" fragment="single">MGRCQCRCRCRCREKGRRWECSWPMRQDGNGWAGMGGMGGTRREQDGRDGHGRGMRGWESGDRDRDNDPQDETGKTTKKEKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4KL64</accession>
    <name>W4KL64_HETIT</name>
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        <submittedName>
            <fullName evidence="3">Phosphatidylinositol transfer protein PDR16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_30399</name>
    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009541979.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="20669306"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_30399"/>
    <dbReference type="eggNOG" id="KOG1470">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014001_1_0_1"/>
    <dbReference type="InParanoid" id="W4KL64"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="100"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW86598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="330" mass="37400" checksum="E4F0C123166D74A1" modified="2014-03-19" version="1">MAKTTQFITAPAPGTVINPVHTYTEEQTAQIAALREYAHSIALPESDPYHPFERRWLDRSDTLPRYMRAAKWKLDDGMKRIKGTLEWRREFKPDLIPPDEVKIEAETGKIILNGFDVDGRPIIYMRPGRENTETSPRQLRHLVWVLERAKDMMPPGQESLMIIVDYKSTTLRTNPSISIARKVLTILQQHYVETLGRALVVNLPMLLSFFYKGIAPFLDPITRDKMRFNPDLFELVPRAQLDADFGGEYEFEWDFESYWAQVVEHCGIAPDGTHIRDNDGPAPAPTSVPTPTLGEQSRQESETPSLTPSSEDTGEPKKDPAAALVEPVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLU5</accession>
    <name>W4KLU5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_308267</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540762.1">
        <property type="nucleotide sequence ID" value="XM_009542467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLU5"/>
    <dbReference type="GeneID" id="20669565"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_308267"/>
    <dbReference type="eggNOG" id="ENOG502SB33">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055491_8_1_1"/>
    <dbReference type="InParanoid" id="W4KLU5"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="11"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW86777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="157" mass="17737" checksum="A3104333B2745757" modified="2014-03-19" version="1">MSTTISVESPLKGGCYCGAVSYAISAPPVTRAFCHCTQCQRLNACPFIHTIHVDALHFTWAHATPHESFLDRFVNPSRPWKQRFRCKSCGCTIASKNSKTNRVSVWGAQLERDDEGKVKRWDEVKPTAHIFYATRMLDIDDGLGKWEGYEGKSKELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMM3</accession>
    <name>W4KMM3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_406786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540914.1">
        <property type="nucleotide sequence ID" value="XM_009542619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KMM3"/>
    <dbReference type="STRING" id="747525.W4KMM3"/>
    <dbReference type="GeneID" id="20672543"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_406786"/>
    <dbReference type="eggNOG" id="ENOG502SZF8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100707_0_0_1"/>
    <dbReference type="InParanoid" id="W4KMM3"/>
    <dbReference type="OrthoDB" id="10251155at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="257" mass="29536" checksum="3BA04BF818C30A00" modified="2014-03-19" version="1">MDSQVLQLQFPDNFDSVPELDHWRCLRCSTGFLQDGNVEIMSLRQAVEHEQTAAHQAKAAAHDPWGPPNTTWGDVRLQDFYSEMKVREKQQWVDQCPERILFWLKGVMAAERGEEVENMQVFLDELDKKREEYEKGLSEGWGSVSWNNNWGWGGGVKDEVEQWQLPEDGWVQAGPKRKRKGKRTSWDKQGGYNVQGGSDEIGARHPIGNSNVPSVARKFTQPQSANLVRKQKMNAFLKMPLDQKADKIQEMIHSLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4KND0</accession>
    <name>W4KND0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exosome complex component CSL4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_308387</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541242.1">
        <property type="nucleotide sequence ID" value="XM_009542947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KND0"/>
    <dbReference type="FunCoup" id="W4KND0">
        <property type="interactions" value="646"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KND0"/>
    <dbReference type="GeneID" id="20669579"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_308387"/>
    <dbReference type="eggNOG" id="KOG3409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067135_3_1_1"/>
    <dbReference type="InParanoid" id="W4KND0"/>
    <dbReference type="OrthoDB" id="440760at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019495">
        <property type="entry name" value="EXOSC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE CSL4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10447">
        <property type="entry name" value="EXOSC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exosome complex component CSL4 C-terminal" evidence="4">
        <location>
            <begin position="90"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW87328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="185" mass="19768" checksum="6040F34CB943046F" modified="2014-03-19" version="1">MASDCLLPGQPVPLPRGPLPQLGSGIYMKDGEPRASLVGIPRYDASTLAISRVRPHPPAPNSIVLGSVTRLSPQQAVVSITVVDGMPLPAGEEFTGVIRVQDVRATEKDKVKIADCFRGGDVVKGLVISLGDARSYYITTARNDLGVLFATSEAGATMEPVSWQEMRCARTGRIERRKCAKPEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNS5</accession>
    <name>W4KNS5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">HETIRDRAFT_443043</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
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    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
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            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
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            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
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        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
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        <property type="protein sequence ID" value="ETW87040.1"/>
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        <property type="nucleotide sequence ID" value="XM_009542694.1"/>
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    <dbReference type="STRING" id="747525.W4KNS5"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
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        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
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        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
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        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
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        <property type="entry name" value="RNA_pol_bsu_CS"/>
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        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
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        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
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        <property type="entry name" value="RNA_pol_Rpb2_3"/>
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        <property type="entry name" value="RNA_pol_Rpb2_4"/>
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    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
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        <property type="entry name" value="PRK09606.1"/>
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        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
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        <property type="entry name" value="RNA_pol_Rpb2_1"/>
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        <property type="entry name" value="RNA_pol_Rpb2_3"/>
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    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb2_4"/>
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        <property type="entry name" value="RNA_pol_Rpb2_6"/>
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        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
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        <property type="entry name" value="RNA_POL_BETA"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="20">
        <location>
            <begin position="50"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="229"/>
            <end position="419"/>
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    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="493"/>
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    <feature type="domain" description="RNA polymerase Rpb2" evidence="22">
        <location>
            <begin position="591"/>
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        <location>
            <begin position="679"/>
            <end position="751"/>
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    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="17">
        <location>
            <begin position="758"/>
            <end position="1130"/>
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    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="1132"/>
            <end position="1223"/>
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    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="30"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="17"/>
            <end position="30"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
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        <source>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
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        <source>
            <dbReference type="RuleBase" id="RU000434"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363031"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF00562"/>
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        <source>
            <dbReference type="Pfam" id="PF04560"/>
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        <source>
            <dbReference type="Pfam" id="PF04561"/>
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        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="ETW87040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1231" mass="139307" checksum="7EC32EFF5F0F3142" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4KNX5</accession>
    <name>W4KNX5_HETIT</name>
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        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 15 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_145522</name>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">TC 32-1</strain>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="GH15-like"/>
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        <property type="entry name" value="Trehalase-like_N"/>
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    <dbReference type="PANTHER" id="PTHR31616:SF0">
        <property type="entry name" value="GLUCAN 1,4-ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
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        <property type="match status" value="1"/>
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    </dbReference>
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            <end position="154"/>
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        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW87512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="692" mass="77533" checksum="72A19355CBCAC839" modified="2014-03-19" version="1"> </sequence>
</entry>
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        </submittedName>
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            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="747525.W4KNZ1"/>
    <dbReference type="GeneID" id="20669477"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_307288"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="2422840at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1111" mass="123749" checksum="4E6D1403DCA5C797" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
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    <name>W4KQL1_HETIT</name>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540304.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KQL1"/>
    <dbReference type="FunCoup" id="W4KQL1">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KQL1"/>
    <dbReference type="GeneID" id="20672512"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_40385"/>
    <dbReference type="eggNOG" id="KOG4186">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049216_0_0_1"/>
    <dbReference type="InParanoid" id="W4KQL1"/>
    <dbReference type="OrthoDB" id="411017at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
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        <property type="entry name" value="PEROXIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW87321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="27429" checksum="D2198F6B4629A883" modified="2014-03-19" version="1">MSSVASQVILHPAVSDTLKVLGTTLGRDKIYRAVQYFARFFAWYLLARGYKLEATRWNALKGHLATARKLMRIGKPLEHLQAALRAAQTTGDLKEQISTIGRQLGYFGYLTYDAIVWANAVRFITLKPDTAQRVNKTANRFWVAGILFSIVHAVFKSGRLTQEVNSLRALTEKDVGEENVRQTRLRTLAALLTATRQQFVIDVLDVWIPAANIGLVTLNDGILGAFGFITSILALRSHWAVTTAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4JMA9</accession>
    <name>W4JMA9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_331983</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009554808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JMA9"/>
    <dbReference type="GeneID" id="20671694"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_331983"/>
    <dbReference type="HOGENOM" id="CLU_3032622_0_0_1"/>
    <dbReference type="InParanoid" id="W4JMA9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW74599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="55" mass="6000" checksum="67FD40B6D281A20C" modified="2014-03-19" version="1">MPPEFSQLTILYSCTTNKNSAGMTTTALYALFSAPTTLEACSGQGDILLFWEISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4JND4</accession>
    <name>W4JND4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_442815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW75072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553518.1">
        <property type="nucleotide sequence ID" value="XM_009555223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JND4"/>
    <dbReference type="STRING" id="747525.W4JND4"/>
    <dbReference type="GeneID" id="20675492"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_442815"/>
    <dbReference type="HOGENOM" id="CLU_715836_0_0_1"/>
    <dbReference type="InParanoid" id="W4JND4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="386" mass="40485" checksum="256DF3395D094317" modified="2014-03-19" version="1">MSFPIDPTYFPDCPQGIKRHVLDWAQHVCADTIPYYRPYIAKIKHCKREGGVWHEFLIIEFIYPISASATRIVPVIVERTIETGQIPHEMIRPGVDLSAQTGQMNVRSEPAWFHSSSYTSVDSSMTSSTYANIGSSSIPPMGAHALDYIHVPQNGASINSIDEGAGSPYQVCRELTFTSRVTDHNLAALLVAVHEHSPIYNVVSRQCYWYAAVIYDVFCVRHGGRSVDHALHGPLRAGRFLTIFTIQPKDPPLDYILPGSGSKGEEGGSGEGTGCCGSKRGSKRCGGNGEGGGSGEGTGYCGSKRGSKRGGGNGEGGGSGEGTGRREGEGGGSGEGTGRCEGEGGGSGEGKGYCGSKRGSKRGGGNGEEGGSGEGTGRRGEEEGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNP7</accession>
    <name>W4JNP7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_423360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553183.1">
        <property type="nucleotide sequence ID" value="XM_009554888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNP7"/>
    <dbReference type="FunCoup" id="W4JNP7">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JNP7"/>
    <dbReference type="GeneID" id="20673898"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_423360"/>
    <dbReference type="eggNOG" id="KOG1472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006198_1_0_1"/>
    <dbReference type="InParanoid" id="W4JNP7"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22927">
        <property type="entry name" value="HFD_SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037782">
        <property type="entry name" value="Spt7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="5">
        <location>
            <begin position="61"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="196"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="361"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="640"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="701"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="553"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="374"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="651"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW74690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="806" mass="88512" checksum="E400BD2137EF5BD1" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNT1</accession>
    <name>W4JNT1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_442461</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552638.1">
        <property type="nucleotide sequence ID" value="XM_009554343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNT1"/>
    <dbReference type="FunCoup" id="W4JNT1">
        <property type="interactions" value="180"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JNT1"/>
    <dbReference type="GeneID" id="20675451"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_442461"/>
    <dbReference type="eggNOG" id="KOG0860">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064620_2_1_1"/>
    <dbReference type="InParanoid" id="W4JNT1"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15874">
        <property type="entry name" value="R-SNARE_Snc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005409">
        <property type="entry name" value="Synaptobrevin_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW75198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="115" mass="12762" checksum="FD12932548EEBCBB" modified="2014-03-19" version="1">MSEPYDPYLPRGGSSSNPPGGAGNAKTAAIQAQIDDTVNIMRDNITKVTERQERLDSLQDKTDNLAVSAQGFRRNANRVRKNMWWKDMKMRLIIGVAIAIIIVIIVVSIVKATKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4JP50</accession>
    <name>W4JP50_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">INO80 complex subunit B-like conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_437260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553161.1">
        <property type="nucleotide sequence ID" value="XM_009554866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JP50"/>
    <dbReference type="STRING" id="747525.W4JP50"/>
    <dbReference type="GeneID" id="20674941"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_437260"/>
    <dbReference type="eggNOG" id="ENOG502S7M7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104745_0_0_1"/>
    <dbReference type="InParanoid" id="W4JP50"/>
    <dbReference type="OrthoDB" id="2021186at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029523">
        <property type="entry name" value="INO80B/Ies2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006880">
        <property type="entry name" value="INO80B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561:SF12">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04795">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01406">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit B-like conserved region" evidence="2">
        <location>
            <begin position="61"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW74666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="273" mass="27666" checksum="75B6EA2CA818DE2E" modified="2014-03-19" version="1">MNDNGGTPSALSIPPGTGPTASGSGSRPMTTRQAVLASVVDSTHVSLTETSRKKKPLNDAELALRREETARKRKHLSEKKLEDEKAETINRLLKKQSRSKTKRSALSTAEDRTPAGASTPALGDADDDAPHPLGTPALAAAATASSLLNGAGTEGAAAGANVHAAAEARPTMYRWLSTTRGAAPGEKTMALAFCVPACALPGGVAGTGTGTGTGAADGMDVDAPALAPVAAHPAAVCAVAGCGRGRKYRLVRDWTRGACGMEHLRALTTPSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPB6</accession>
    <name>W4JPB6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein YIF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_67728</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the YIF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552523.1">
        <property type="nucleotide sequence ID" value="XM_009554228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPB6"/>
    <dbReference type="FunCoup" id="W4JPB6">
        <property type="interactions" value="305"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JPB6"/>
    <dbReference type="GeneID" id="20678822"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_67728"/>
    <dbReference type="eggNOG" id="KOG3094">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047877_2_2_1"/>
    <dbReference type="InParanoid" id="W4JPB6"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005578">
        <property type="entry name" value="Yif1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083">
        <property type="entry name" value="YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083:SF0">
        <property type="entry name" value="YIP1D-INTERACTING FACTOR 1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03878">
        <property type="entry name" value="YIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW75373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="239" mass="26700" checksum="8B255EA720733BF2" modified="2014-03-19" version="1">MQLGHNAVAAGQDYVQRNLGGMIPVTHLKHHFNVSNSYVIRKLRLVLFPWRHRPWTRRMWRSEQGHSEFQPPRDDINSPDLYIPVMAFVTYVLLAALQSGLQSRFDPEILGLTATTALFIVFADFLVLKGGCYILGIQSSSPVVDLMAYCGYKFVGVILTLTAGLLKAGRTVWMLVFLYAFLANAFFLLRSLRSVVLPDVSGAPAAVGTVSHAQRSRRITFLFVVAVTQVLYMGVLVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPH8</accession>
    <name>W4JPH8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_461334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552890.1">
        <property type="nucleotide sequence ID" value="XM_009554595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPH8"/>
    <dbReference type="GeneID" id="20677158"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_461334"/>
    <dbReference type="HOGENOM" id="CLU_1261661_0_0_1"/>
    <dbReference type="InParanoid" id="W4JPH8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW75477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="219" mass="25336" checksum="34AA219474896F54" modified="2014-03-19" version="1">MQSPRIGPAVVVRSSTPFKESLGGSIARGLTRSIVKPLLKEELINTLQIDLLIEDFVYRIWGFHPDRLQWKNFFYLFQLDETLVEAYKATFHYPEPYRYAPFARLIDSTVAKLVEVLKLESPLPVSFEPLGSTYIRSDRSNRKLDMGIIGKRAVEEYRLAQDNPDKYSKARLRWETIPCFMEFKRFLLIDHDAVILFPQAPAAISEPVAIAPETENEWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPK5</accession>
    <name>W4JPK5_HETIT</name>
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        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_482200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
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        <property type="protein sequence ID" value="ETW75468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552883.1">
        <property type="nucleotide sequence ID" value="XM_009554588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPK5"/>
    <dbReference type="STRING" id="747525.W4JPK5"/>
    <dbReference type="GeneID" id="20678016"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_482200"/>
    <dbReference type="eggNOG" id="KOG3677">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029210_0_1_1"/>
    <dbReference type="InParanoid" id="W4JPK5"/>
    <dbReference type="OrthoDB" id="15082at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="332"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="570"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="581"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW75468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="607" mass="68909" checksum="96E558EF4CD1FB75" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPP2</accession>
    <name>W4JPP2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_456358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009555016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPP2"/>
    <dbReference type="GeneID" id="20676734"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_456358"/>
    <dbReference type="HOGENOM" id="CLU_924559_0_0_1"/>
    <dbReference type="InParanoid" id="W4JPP2"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW74836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="301" mass="32047" checksum="1A101ED387F3C649" modified="2014-03-19" version="1">MPVPTEVSASLAQTPPYRPPPPFHTATSSVTPLPPSTPSPIGHPAGVPPTAYTRQEGYFPPGPTVPMLRPDVSPGWGPYVTLPQLRLYPFYAPFSQSVPFTGAMLPFSYHGPQPPTLARWLKPSKAERKRLKAERKRLNAIQVETTRLQGVKDWLEKYNGAATDTDNEASEKAAASEKINVPAADIATAMAARAANVAARHAVATAIRADTVAYRAFATAVDAAGAAVAAADAALKAAADAVAAAAMRDMEKQNSEIVTKPADNDVNQSLEHTVEEMAAEQDGPRHELSDLHTEEDERSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4JQ48</accession>
    <name>W4JQ48_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_460967</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
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                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </subcellularLocation>
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        <source>
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</entry>
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    <accession>W4JQ88</accession>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
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                <person name="Cullen D."/>
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                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
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                <person name="Hietala A."/>
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                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
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                <person name="Yakovlev I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">TC 32-1</strain>
        </source>
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        <source>
            <dbReference type="EMBL" id="ETW75727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
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</entry>
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                <person name="Bouzid O."/>
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                <person name="Cullen D."/>
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                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
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                <person name="Hansson D."/>
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                <person name="Himmelstrand K."/>
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                <person name="Kues U."/>
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                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">TC 32-1</strain>
        </source>
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        <property type="entry name" value="WD40_rpt"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108:SF4">
        <property type="entry name" value="BLUE CHEESE"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF13385">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
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    </dbReference>
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        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
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    </dbReference>
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        <property type="entry name" value="PH domain-like"/>
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        </location>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="ETW75285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2035" mass="229697" checksum="4297B3339C1C6991" modified="2014-03-19" version="1"> </sequence>
</entry>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
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                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
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                <person name="James T.Y."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
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                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">TC 32-1</strain>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_390437"/>
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    </dbReference>
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        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="206" mass="22219" checksum="126C8F8064F8A808" modified="2014-03-19" version="1" fragment="single">MESRESVLQVAATASVVSSVAGPTTSRCVPGGSSCLSCYNELGGHQSLGGHAAFFFFFLFLADHVLGDCKSLHLYARVGSEGGWTRCPQMPHCGTRIFSSPLPSGKFSSLVDLWSHSGNPLRQLACRERARRSTDAGAESPALVRRRFFSCDCVLMILGFPSGEPPVVLAEGGGRRPGSLHTSSVWYLHKSIFFIFFVSHSESACQ</sequence>
</entry>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Gonthier P."/>
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                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
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                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
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                <person name="James T.Y."/>
                <person name="Karlsson M."/>
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                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
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                <person name="Raffaello T."/>
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                <person name="Salamov A."/>
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                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="InParanoid" id="W4JTS5"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="ETW76849.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="711" mass="78387" checksum="37982B50863C8833" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="17" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
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                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">TC 32-1</strain>
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    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="94" mass="11032" checksum="D399E8051C0CF58B" modified="2014-03-19" version="1" fragment="single">AGILIEPQQLYADLWTYLDNAAKIKQLESRLYPFQSLSLMTYCLDWQPRSTSHKNFGCHPQPYFSYVRKEGSTRRHHRRILDFAVLITTDGVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>W4JU62</accession>
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            <fullName evidence="3">DUF6697 domain-containing protein</fullName>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
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                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
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                <person name="Gonthier P."/>
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                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
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                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
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                <person name="Karlsson M."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Morin E."/>
                <person name="Murat C."/>
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                <person name="Raffaello T."/>
                <person name="Rouze P."/>
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                <person name="Schmutz J."/>
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                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW76999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550556.1">
        <property type="nucleotide sequence ID" value="XM_009552261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JU62"/>
    <dbReference type="GeneID" id="20671343"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_327583"/>
    <dbReference type="HOGENOM" id="CLU_049204_0_0_1"/>
    <dbReference type="InParanoid" id="W4JU62"/>
    <dbReference type="OrthoDB" id="3214033at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046520">
        <property type="entry name" value="DUF6697"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20411">
        <property type="entry name" value="DUF6697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6697" evidence="3">
        <location>
            <begin position="253"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="392"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="96"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW76999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="450" mass="50993" checksum="CEDDB5F7CD858EDB" modified="2014-03-19" version="1">MAATVEDHTGPSRTNESDQSPLASVSVRNRISIDASYAPEMVKFWAKKYQDAKKELDLLKVRICITFFSSEASCRDSDKAVTVCLKQRHLFTQPDRNELQQEQKSLKTLVSQLKSESRVRAAYEKELNKTVVKAQQQKDKWQEEVVRFEKERTETVGKVADLEAENEALKQSRTSMVNVMLWLRRLIKVGGPRSRQFTPVSFIDPVFLEGIKPVQLPETLLDALGPKVSLMLSGDRPSMQSDIHFIRRPPICMPLCVEECGMHGHWFYPTAQVRENTPVDLVIESTPNMWMYLGKYLCAFMPVSEMQLSEWMNLNEITKVIHCRQVVSAGLPPDQSVLLPAQMTMKRRYETGEWSVPCFSLRCVGFDVDLYNSLHLAVEELMRPTAALEKRPVRSDAENDAVNKRIRITQSPGRPSGNGTDVSPAQSSSLTYDPHPELNPENILASPHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUA9</accession>
    <name>W4JUA9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GEgh 16 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_480825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551551.1">
        <property type="nucleotide sequence ID" value="XM_009553256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUA9"/>
    <dbReference type="GeneID" id="20677933"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_480825"/>
    <dbReference type="eggNOG" id="ENOG502QUBE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047729_5_0_1"/>
    <dbReference type="InParanoid" id="W4JUA9"/>
    <dbReference type="OrthoDB" id="3241054at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021476">
        <property type="entry name" value="Egh16-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618:SF1">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618">
        <property type="entry name" value="SURFACE PROTEIN MAS1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11327">
        <property type="entry name" value="Egh16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844963" description="GEgh 16 protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="28096" checksum="3E919F6BD52E6616" modified="2014-03-19" version="1">MFFNALLASVVVAASLVSQTSAHGTITAVTGANGVNAAGFGIIATTPRDGSKANPFEQDTSVIKNQEIASGKVGVCGRTKAGGNNDVAAQLAAASAAGLPTASADGTVSMTLHQVNGDGAGPYTCDVSADGGNTFIAATVTTQVPGRNGRSQAKAQDFPLEVQMPAAMTCEGGPNGDACIVRCRNPVGPFGSCVAIASADSASNATASAAPAAVAGATAGAASVSNSTAAAPAAGAVASSAAVAVAAPSADSNVSASGQTAAATKQAKAAKNAKRIITSRVAGKRAGYWIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUK0</accession>
    <name>W4JUK0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_174637</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551450.1">
        <property type="nucleotide sequence ID" value="XM_009553155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUK0"/>
    <dbReference type="STRING" id="747525.W4JUK0"/>
    <dbReference type="GeneID" id="20668519"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_174637"/>
    <dbReference type="eggNOG" id="KOG4178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_7_0_1"/>
    <dbReference type="InParanoid" id="W4JUK0"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="29"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW76561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="329" mass="36598" checksum="3F85CDF0C04FA048" modified="2014-03-19" version="1">MDASLFKKHITQRGFTYNYFRVSAEAGKPTLVLLHGFPSSSWDWHYQVDFFKPRGYGLVVPDMLGYAGTDKPTDAKFYIGSGLAQDIVDILDKEDVQKSVLIGHDWGSRVVSRLANNHPDRFTAIGFLALAYLPPNPVHDPAAQSARIKQLVGRDLFGYWDYLAEEGADKMIKKNFNSFLSIFFSGSGEIALKNLCPPGALKEWIEANNQGPIAPFLTVEDQEHYRQTLLGGGLASPVAWYKIQTTAGSIRAEDDKLVPKEAYDIQQPVFFGAALRDIVCLPALGNALLKQYAKGPLTVKEFDAGHWVLLSHPKEVNEALLEWIEGLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4JUM4</accession>
    <name>W4JUM4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 monooxygenase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cyp4</name>
        <name evidence="11" type="ORF">HETIRDRAFT_52060</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550486.1">
        <property type="nucleotide sequence ID" value="XM_009552191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JUM4"/>
    <dbReference type="GeneID" id="20678202"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_52060"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_3_1"/>
    <dbReference type="InParanoid" id="W4JUM4"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW77258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="514" mass="57722" checksum="8B6308E231C3D78D" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W4JVI3</accession>
    <name>W4JVI3_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_327145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551039.1">
        <property type="nucleotide sequence ID" value="XM_009552744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JVI3"/>
    <dbReference type="FunCoup" id="W4JVI3">
        <property type="interactions" value="557"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JVI3"/>
    <dbReference type="GeneID" id="20671301"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_327145"/>
    <dbReference type="eggNOG" id="KOG0686">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022348_1_0_1"/>
    <dbReference type="InParanoid" id="W4JVI3"/>
    <dbReference type="OrthoDB" id="422427at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="232"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW77552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="508" mass="55064" checksum="5F87BCE42C9BC824" modified="2014-03-19" version="1">MDIDIEDVDINLAIDASTSAASAGKQANRVEIVPVDDAHPFDLDAYISGYTGRAAIDRLSHIILHAPAVAPQALRLALTLLTEPSQRDATLYQSLLSTYESALAQTRTLPPLADVLPDHSPYVRWAEETAAANQAERVKLEVELKTYTNNMIKESIRMAHRDLGAFHRTTGQYDLALRHYTKSREFCTTGAHVLEMCLSVLELLIEQRNYAHIPTYIFKAENALDGLSSSAAAPIASSSTAATAAAPPASQSTKKDPYAPTYAKLALCNALSLLSQGAYAKAGAKLLSLPASGAGGTWIGTIVGPGDISTYATLCALATLDRPEVKRKLVDGDAAPAVGEGGMRELVDAWMTSRFKTVLELLQRYSTRHALDPILAPHVASLTTLIRARAIVLYFQPFATVHLDRMSAAFGWSVADTEREVVDLIQRGEIQARVDSQNKILKARTIDARAQLYARALRAGDEMRSATRKLLLRMRLQQADLVVRKTQPGNAHILAAGPFSQGSEPMIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4JWR2</accession>
    <name>W4JWR2_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carnosine N-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_327542</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnosine N-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="KI925463">
        <property type="protein sequence ID" value="ETW77530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551021.1">
        <property type="nucleotide sequence ID" value="XM_009552726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JWR2"/>
    <dbReference type="FunCoup" id="W4JWR2">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JWR2"/>
    <dbReference type="GeneID" id="20671340"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_327542"/>
    <dbReference type="eggNOG" id="KOG2798">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030612_0_1_1"/>
    <dbReference type="InParanoid" id="W4JWR2"/>
    <dbReference type="OrthoDB" id="978at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030735">
        <property type="term" value="F:carnosine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF6">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW77530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="299" mass="33904" checksum="F8AAC3A3B5C766F5" modified="2014-03-19" version="1" fragment="single">HSHSHEHSHDLQIRSHGPSGKLSSHKRYRPTDFDMDKVRSTLKQFVRDWSQEGREEREASYTPLKDALVEHFSDIPVEERRNLHVLVPGAGLGRLAFDVAKLGFACQGNEFSHYMLLSSYFILNCTDTINQYTLYPYVHSFSNLPDRAAILREVKIPDVLPGGLAPGSNFSLVAGDFEEIYGSDSDDENGPYSGPWDAILTCFFIDTAKNIVNYLRIIHKILAPGGVWINLGPLLWHFENNSSNDPSIELDLEEVKELARTIGFEIKNERTISTTYVNNQDSLLGYVYHAAFWIATKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4JXW7</accession>
    <name>W4JXW7_HETIT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_326154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009551975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JXW7"/>
    <dbReference type="GeneID" id="20671213"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_326154"/>
    <dbReference type="eggNOG" id="ENOG502SADP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_195672_0_0_1"/>
    <dbReference type="InParanoid" id="W4JXW7"/>
    <dbReference type="OrthoDB" id="2278877at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043457">
        <property type="term" value="P:regulation of cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044792">
        <property type="entry name" value="TAR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47188">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47188:SF1">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="83" mass="9300" checksum="B904D4EF165798B3" modified="2014-03-19" version="1" fragment="single">SFAPIPKFDDRFARQNRYEPPPEFPLASPYSGIVHHLSGPNIHALPQIRHRSSGPGVGALHDRGPNFHFHYAHGFPPEHSRAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZ04</accession>
    <name>W4JZ04_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydrofolate reductase</fullName>
            <ecNumber evidence="2">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_323473</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="2"/>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549025.1">
        <property type="nucleotide sequence ID" value="XM_009550730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZ04"/>
    <dbReference type="STRING" id="747525.W4JZ04"/>
    <dbReference type="GeneID" id="20670966"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_323473"/>
    <dbReference type="eggNOG" id="KOG1324">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043966_2_1_1"/>
    <dbReference type="InParanoid" id="W4JZ04"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046452">
        <property type="term" value="P:dihydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017925">
        <property type="entry name" value="DHFR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069:SF3">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00070">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00075">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="8">
        <location>
            <begin position="3"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW78709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="218" mass="23367" checksum="AF49400E69103F3F" modified="2014-03-19" version="1">MSRLTLIVAATASNGIGKDAGLPWRLPKEMAYFARATAGAPAGLANVVIMGRNTWESIPPRFRPLRGRANAVVSRNAGYDLSAGASVVDADTSASLHADLRSALDSLEGDGGASRARIHRRFVIGGASLYAEALALPPLAARAFVDRVLLTRILSPAFDCDVFMPDFLESGSGGAGGRWERASDEELSAWVGFDVPMGVQEERGVRYEFQMWTRQAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZ36</accession>
    <name>W4JZ36_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_420932</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
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    </evidence>
    <sequence length="111" mass="12805" checksum="C7CAE951701BCA38" modified="2014-03-19" version="1">MAETQPKIRIMQGAEQDLSAATYQIFDESHTLGNALRWMIMKNPKVEFCGYSVPHPSENLIQLRIQMYDNLSSLTALQTALDDLDTLYESIEDAYRASLEQDHYEKFIEQS</sequence>
</entry>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
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                <person name="Cullen D."/>
                <person name="Dalman K."/>
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                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
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                <person name="Rouze P."/>
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                <person name="Yakovlev I."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">TC 32-1</strain>
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    </dbReference>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW78744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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    </protein>
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                <person name="Cullen D."/>
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                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
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                <person name="Lunden K."/>
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                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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    <dbReference type="InParanoid" id="W4JZ50"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="303" mass="33142" checksum="45C8D93B549B765D" modified="2014-03-19" version="1">MAAGPKPAPRDDLLAVRLVVSLPSVGKQPATQLWPAAVGHRQGKPRDMWPKKRANAECGDESPVQWPKTSNLTSPADQQITEFIVSQSETTAKRKAPLDETNSKSIHRSKRARTSREDVHVAEAEAVEGFRFALQMLAEFEVARSNTEEFNNGHDEDHFYMVHPSVEAIPAFAAGPDHQPGLGTPGTTQKGGKAPARKASVRAEGKARGNRAADVQAEDETEGKAKKPRADPWRRKLPRNGSWVCELCGTKLDVYTISPDTIEPSTKGLMAPSNASVGLSSHQCREDALARHKRNSRGWPLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZF6</accession>
    <name>W4JZF6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein L37ae</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_387068</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549138.1">
        <property type="nucleotide sequence ID" value="XM_009550843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZF6"/>
    <dbReference type="FunCoup" id="W4JZF6">
        <property type="interactions" value="470"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JZF6"/>
    <dbReference type="GeneID" id="20672302"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_387068"/>
    <dbReference type="eggNOG" id="KOG0402">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141199_1_0_1"/>
    <dbReference type="InParanoid" id="W4JZF6"/>
    <dbReference type="OrthoDB" id="10258345at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000002">
        <property type="entry name" value="60S ribosomal protein L37a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_eL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050522">
        <property type="entry name" value="Ribosomal_protein_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003058">
        <property type="entry name" value="PRK03976.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW78839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="10269" checksum="697EBFD68A413E5E" modified="2014-03-19" version="1">MTKRTRKVGVTGKYGTRYGASLRKQVKKMEITQHARYTCTFCGKDSVKRQAVGIWKCKACRKVIAGGAWTVTTTAAATVRSTVRRLREITEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZJ7</accession>
    <name>W4JZJ7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_172543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549254.1">
        <property type="nucleotide sequence ID" value="XM_009550959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZJ7"/>
    <dbReference type="GeneID" id="20668403"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_172543"/>
    <dbReference type="HOGENOM" id="CLU_2942033_0_0_1"/>
    <dbReference type="InParanoid" id="W4JZJ7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="60" mass="6601" checksum="4DEC5925ED6DC759" modified="2014-03-19" version="1">MTTQGHKYKDPQLIRSDQDRTSTSRVFCHLAIGLEEVECSFLSGALTTSQAGGRRADMAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZL7</accession>
    <name>W4JZL7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_453187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548871.1">
        <property type="nucleotide sequence ID" value="XM_009550576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZL7"/>
    <dbReference type="GeneID" id="20676354"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_453187"/>
    <dbReference type="HOGENOM" id="CLU_132759_0_0_1"/>
    <dbReference type="InParanoid" id="W4JZL7"/>
    <dbReference type="OrthoDB" id="3235294at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW78535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="155" mass="17475" checksum="DA5EC42DEB5C04F9" modified="2014-03-19" version="1">MSHWSDLNYYPAFPDNNASKPIYFETPGLEPAAVLGSRHVLLIWDNDRGGTLVHQVMQLTGIPSRYFYDTSPVAKLRNPATRPLNTYISLGTFTRAQRDAILELAKAVPYDPASYINGCQVWTRDLLQAMIAHGYLAESTFRQIEAVVPLIHRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZM2</accession>
    <name>W4JZM2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_386706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548876.1">
        <property type="nucleotide sequence ID" value="XM_009550581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZM2"/>
    <dbReference type="GeneID" id="20672288"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_386706"/>
    <dbReference type="HOGENOM" id="CLU_797074_0_0_1"/>
    <dbReference type="InParanoid" id="W4JZM2"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="337" mass="37262" checksum="F91B9FC2B81A6759" modified="2014-03-19" version="1">MERDNTHSAPLKIPAYRMRISPSTHVSITLTSFTPFSPAPVDDILLSKAVNMASLVRTSSHGAQTPNIDDHRASTNTFGYVEGENDVQHDRRVVDQLRLDISTLQTNSARELQAVKTDMAVRFAEVNGTLVQHSKDLSTVKTTVESLQTSVEGLKKQGDKHEALIHSLHTMMERQEEMMKRQQESLDSHSRILKLLASRADVDILEDLPALQATGSAVALPEVVVTHTPTSSVSSTEPQFRASTPPSPPSRAGPSTLPVPFSQTAPSYRLSEENVLLSLPNVLRLRTQSEPDVREALGAREGRETFRPLEADRRPEVKKGFRDVAKLFRKTFSNKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZT3</accession>
    <name>W4JZT3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_410883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW79083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549352.1">
        <property type="nucleotide sequence ID" value="XM_009551057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZT3"/>
    <dbReference type="GeneID" id="20672905"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_410883"/>
    <dbReference type="HOGENOM" id="CLU_3087506_0_0_1"/>
    <dbReference type="InParanoid" id="W4JZT3"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="52" mass="5704" checksum="A1F3212BDD90333A" modified="2014-03-19" version="1">MGVGSLKQAGDWDGRDMDARDEGTKKKGNSTHFGWGDIIMIEWDGMGWDGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4JZY7</accession>
    <name>W4JZY7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="9">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_325266</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KI925462">
        <property type="protein sequence ID" value="ETW78411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009550382.1">
        <property type="nucleotide sequence ID" value="XM_009552087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JZY7"/>
    <dbReference type="STRING" id="747525.W4JZY7"/>
    <dbReference type="GeneID" id="20671130"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_325266"/>
    <dbReference type="eggNOG" id="KOG0558">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_10_0_1"/>
    <dbReference type="InParanoid" id="W4JZY7"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031405">
        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000013">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050743">
        <property type="entry name" value="2-oxoacid_DH_E2_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178:SF5">
        <property type="entry name" value="LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="11">
        <location>
            <begin position="33"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="12">
        <location>
            <begin position="168"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW78411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="507" mass="54920" checksum="F3C09A05E0AD852D" modified="2014-03-19" version="1">MLLLRSSRRLLGRPAFRSHFHSSQTFWATRKVLQKFKLADIGEGITECEVIKWSVIPSGNISAFDPLCEVQSDKASVEITSPFDGTVKEILVQEGEVAKVGEDLCIIEVDEEVQETTDSADHASSSDGVSSPAQIQGDAFRPSELRRPHPLDPNHAEQVFVKNTKDVLALPAVRHFARLSGVDLSLLAPGSGKNGRIEKSDVEGYLSRGKQAAGIQTRARGAVSLEEDVVVELGRTRYGMWKAMTKSLEIPHFGYSTYLDLTALHNILPILNAHIPEHFLPAPSVPPPLASVSPASLYPPPCPPPVPDTGRYTKLTYLPILLKTLSKAMVEWPLLRSSITPTASSIPPNTKPTITIRPHADISIALSTPTGLYTPTLQRVDTYSIYALASSLKHLSHLGRQVPSGLTLAELPKRGGTLTVSNVGAIGAGEVAAPVLVPGGGVAIVALGRARWEWDVNRGDGKGERRLKVGVSWSADHRVVEGAELAAFVERWRAYVEQPERMIAEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>W4K004</accession>
    <name>W4K004_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_219397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548988.1">
        <property type="nucleotide sequence ID" value="XM_009550693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K004"/>
    <dbReference type="GeneID" id="20668647"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_219397"/>
    <dbReference type="eggNOG" id="ENOG502SXYS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068189_0_0_1"/>
    <dbReference type="InParanoid" id="W4K004"/>
    <dbReference type="OrthoDB" id="128646at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW78670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="45572" checksum="A243C536621322F3" modified="2014-03-19" version="1" fragment="single">MKSHSAPSLRIETILIGKNRKAATQALVDSGATGIFMHPRFVETHRIKTRKTPAPIPVNTVQNTEFKGGPITKFTELKLQVLGEQGGTHTESAKFYIAEIGKEDVILGTGWLLEHNPEVDWHAYGLHFTRCPPSCQIKGGPIKAKRATRKPGRQNPEIQRIETVPRKNDYSITLQKPGQAQPGRKVGNATVPHPRIKPNIRGSQPEGRNPEYLRARAKHYAAPTWAEEDTPEDGVRLSALPSTDLEEDGVYLVRCLNTRQLEALELYNDGKENIDIHRIETTETLVTNTPVPRKEPIGKQTKHTNSQKLAEEASKGKPELSFEEIVPKEYWDYRKVFEGRKPGKLPPKRPWDHKIELKDGMEHSLRPKLYSLSPMEQTELKKFIDENLKKGFIRESKSHIASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0I6</accession>
    <name>W4K0I6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_428632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925461">
        <property type="protein sequence ID" value="ETW78830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009549130.1">
        <property type="nucleotide sequence ID" value="XM_009550835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0I6"/>
    <dbReference type="GeneID" id="20674288"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_428632"/>
    <dbReference type="HOGENOM" id="CLU_348176_0_0_1"/>
    <dbReference type="InParanoid" id="W4K0I6"/>
    <dbReference type="OrthoDB" id="3197870at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="510"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="639"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="754"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="418"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="510"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="639"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="664"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="687"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="762"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW78830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="810" mass="90621" checksum="D794C5FBFEB0FD0E" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4K0Y4</accession>
    <name>W4K0Y4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_117335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548049.1">
        <property type="nucleotide sequence ID" value="XM_009549754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K0Y4"/>
    <dbReference type="GeneID" id="20666548"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_117335"/>
    <dbReference type="HOGENOM" id="CLU_1042280_0_0_1"/>
    <dbReference type="InParanoid" id="W4K0Y4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW79462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="267" mass="29379" checksum="C0B1BF890FE697AE" modified="2014-03-19" version="1">MCAFADRSITSTSIRMRVNRDARGINKISSTTFVPTSMAALLVTTIDSFSFPTHGEENPRTPGKGRDTQEESRIPSDRLSIVEGGTMSARIKFKRLSTLQAWRETNENNRMWFTQDSSWERSAQCRWVFLKGAASAKISEITLRREATTRTNTKQKTIVVTVSIAADAQVRDLAAAALAWKMVAVQLGVAKEKSKGTQMLGGGPVTSCLFSSHNMTATFDPLSRSDGAEATAEKNDAFLSPPCRTARAPRSRHWQTAPRSTIGSMRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4K163</accession>
    <name>W4K163_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 monooxygenase 21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cyp21</name>
        <name evidence="10" type="ORF">HETIRDRAFT_35637</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547916.1">
        <property type="nucleotide sequence ID" value="XM_009549621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K163"/>
    <dbReference type="GeneID" id="20671798"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_35637"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_3_1"/>
    <dbReference type="InParanoid" id="W4K163"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW79573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="524" mass="59023" checksum="F44FB69966F1822B" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4K1B7</accession>
    <name>W4K1B7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_117307</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009549801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K1B7"/>
    <dbReference type="GeneID" id="20666547"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_117307"/>
    <dbReference type="HOGENOM" id="CLU_1390408_0_0_1"/>
    <dbReference type="InParanoid" id="W4K1B7"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="196" mass="22002" checksum="ACB50E1473D5FB7E" modified="2014-03-19" version="1">MSRRMARREVFLRLCAFTIEAPTDFEVEVTLNLQEMPQGCHGLQDRARQIPIAMVHESPRGRERAIFAIAGHVGLVDTATKQDHTEAKKKAKNILAETRKCKDTYSEPQWWRGNVPKEPRYQNAFADEFAGVGALETTTSHSKGLFPPSQKIVPTVKNGLSEATHVVQARVSSVDCTVIKVEQVIIKEPRPQIKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4K224</accession>
    <name>W4K224_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_452607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009549687.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="W4K224">
        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K224"/>
    <dbReference type="GeneID" id="20676276"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_452607"/>
    <dbReference type="eggNOG" id="KOG1210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_3_0_1"/>
    <dbReference type="InParanoid" id="W4K224"/>
    <dbReference type="OrthoDB" id="10267115at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Short-chain dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW79395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="329" mass="36124" checksum="2769BD0AA8E124ED" modified="2014-03-19" version="1">MFGRSEWNPSMKHCYITGGSSGLGLALAKMLSSQGAHVSIVARDSEKLADALAEIEGVRQSKDQIHQAFSFSLFTADDSRAALDAAAAKHGGVPPDIVFLCAGKAIPRFFVEYTEAELVDGMNYGYWVQAWTAWIVTQQMVVHKRTGSIIFVSSTLGLMTIPGYSGYSPGKHALRGLADTLRCELLLYDINVHIFFPPTMFTPSYEEENKIKPKITKKIEETDGGLTAEQAAAGLLTGLRKGHAHITADMLTDSFRASTRGSAPANNWILDGLIDLASKIWVPVWSTITDRRVKAHKREHHQYLEDIDFFSAQGSLSVFCESWQAASAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>W4K294</accession>
    <name>W4K294_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_49014</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine = N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10234"/>
            <dbReference type="Rhea" id="RHEA-COMP:10236"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8 9 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW79839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547934.1">
        <property type="nucleotide sequence ID" value="XM_009549639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K294"/>
    <dbReference type="FunCoup" id="W4K294">
        <property type="interactions" value="437"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K294"/>
    <dbReference type="GeneID" id="20678092"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_49014"/>
    <dbReference type="eggNOG" id="KOG0820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041220_2_3_1"/>
    <dbReference type="InParanoid" id="W4K294"/>
    <dbReference type="OrthoDB" id="74991at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052909">
        <property type="term" value="F:18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.480:FF:000002">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000007">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF7">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 9 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="12">
        <location>
            <begin position="52"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW79839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="321" mass="36258" checksum="972BFF8D6DDEE00E" modified="2014-03-19" version="1">MPRATSDRFTRAHQPSAKASVSKGQGESSSATRNPIFNTERFGQHILKNPSIAQEIVDKANLRPTDKVLEVGPGTGNLTVKILEKAKQCTVIEMDPRMAAELTKRVQGKPEQRRLEIIIGDFVKADLPYFDVCISNTPYQISSPLVFRLLSHRPLFRTAILMFQREFALRLVAKPGSTLWSRLSANVQLYAKVDHIMNVGKNNFRPPPNVESSVVRIVPLDPPPPVKFEEFDGLTRIIFSRRNKTTHGNFQAKGVTEMLEKNWRTWCSEQNMMVEDVVNMKNKIKDILEETGFCESRAAKMDVNDLLKLLSAFHDGGIHFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4K2M8</accession>
    <name>W4K2M8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_117007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548596.1">
        <property type="nucleotide sequence ID" value="XM_009550301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K2M8"/>
    <dbReference type="GeneID" id="20666530"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_117007"/>
    <dbReference type="HOGENOM" id="CLU_1102905_0_0_1"/>
    <dbReference type="InParanoid" id="W4K2M8"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW80072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="252" mass="27577" checksum="B54B899BBB91B131" modified="2014-03-19" version="1">MSPQAASSVQMGSHRTSRPVPDPAPHGRAPDRMGHTLPGMVERTQPTRARLKRSFGHQRRQWLRQGALVTPRGQAPLAGISRTGWKAPMQRVANTSAFRALPHELYLASISSSRLAELDTDQPHCSILVPSRAARRGLDAMSGGIDVYILQTSFSIALFMDSNTFGSTQPGTDSLHSSQPWCPLHYAGTAMQKNVHLALSHLTYGTVIAESRCIPKDRLKRVSLVQKKKSSYLLLPDTLPSAILARGDRSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4K332</accession>
    <name>W4K332_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Permease of the drug/metabolite transporter superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_65272</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546992.1">
        <property type="nucleotide sequence ID" value="XM_009548697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K332"/>
    <dbReference type="FunCoup" id="W4K332">
        <property type="interactions" value="390"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K332"/>
    <dbReference type="GeneID" id="20678726"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_65272"/>
    <dbReference type="eggNOG" id="KOG1443">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022332_1_0_1"/>
    <dbReference type="InParanoid" id="W4K332"/>
    <dbReference type="OrthoDB" id="18894at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="55"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="366"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="385"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW80227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="441" mass="48996" checksum="AF330D30CC246068" modified="2014-03-19" version="1">MSGLHDENGGPPEYPPDYTLDDLNGPQSTLNTDIHFADSLEKKRLWWRNAVINAAFIASWFTFAIVISLYNKWMFSADHFAFPYPLFATTVQMFFQFCFAAIMRYGWPRKFRPKHVPSRADYGRKAVPTGILTGLDIGLSNLSLKTITLSFYTMCKSSSLIFVLLFAFLFRLEKFSYRLVGVIFLIFIGVLLMVATETHFVLSGLILVLSASASGGLRWSLTQVLLKNKKMGLDNPAATIFWLSPVMGVSLAIVSVAVESWTTLFRSRFLSGLTETLTTTVSLFVPGVLAFSMVLSEYYIIQRIGVVPMSIAGIAKEVTTITISAWVFGDELTPLNITGVAITICGIGLFTYHKYRKSMDSSVPLDVHGNPVTDEDGDMEDGSLLGSSHETTPLVLSSTEQFDRDDRQGTESRGVPVLFSADGQEDEEHLYSSEDGHRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>W4K466</accession>
    <name>W4K466_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_233267</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547358.1">
        <property type="nucleotide sequence ID" value="XM_009549063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K466"/>
    <dbReference type="GeneID" id="20668729"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_233267"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_18_5_1"/>
    <dbReference type="InParanoid" id="W4K466"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051631">
        <property type="entry name" value="Ankyrin-KH/SAM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23206">
        <property type="entry name" value="MASK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23206:SF7">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW80633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="103" mass="10801" checksum="723D161332AEA4D2" modified="2014-03-19" version="1" fragment="single">EGGVHWKAQAASHSGHEAIARLLLDRGAEVNAQEGEYGNALQAASCFGRDVMLLEKGAEVDARRGNGGFALQAASQGGHETVVKLLLDRGAEVNAQRVHKSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4K483</accession>
    <name>W4K483_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_171353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925460">
        <property type="protein sequence ID" value="ETW80155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009548671.1">
        <property type="nucleotide sequence ID" value="XM_009550376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K483"/>
    <dbReference type="GeneID" id="20668331"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_171353"/>
    <dbReference type="HOGENOM" id="CLU_003921_8_1_1"/>
    <dbReference type="InParanoid" id="W4K483"/>
    <dbReference type="OrthoDB" id="5596707at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW80155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="121" mass="13456" checksum="3C2C89241B4D765D" modified="2014-03-19" version="1">MSEGICNKLALIYDPEIVLNMQSANGEIDRSLGLARNVPFLISDITLYLQVHIIQNPAYDVLLGQPFDILTESIVKNYSNEDQTITISDLNTGQQATIPTIRQGPPQVLHQRQAGFCDLMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4K592</accession>
    <name>W4K592_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HETIRDRAFT_155003</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547663.1">
        <property type="nucleotide sequence ID" value="XM_009549368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K592"/>
    <dbReference type="FunCoup" id="W4K592">
        <property type="interactions" value="74"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K592"/>
    <dbReference type="GeneID" id="20667540"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_155003"/>
    <dbReference type="eggNOG" id="KOG3771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072096_0_0_1"/>
    <dbReference type="InParanoid" id="W4K592"/>
    <dbReference type="OrthoDB" id="446293at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07591">
        <property type="entry name" value="BAR_Rvs161p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000014">
        <property type="entry name" value="Protein hob3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037429">
        <property type="entry name" value="Rvs161/Hob3_BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="4">
        <location>
            <begin position="17"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ETW80977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="264" mass="29932" checksum="E3FD03E9A7A201FF" modified="2014-03-19" version="1">MSWSGFKKSMNRAGTTILQKAGQVERTVDQDFATEEAKYKQFEKECQALQKDGKGYLDAMRAMTAAQLRLAETIETFYGAADRTSEGSMAAHAYKRNVEELDNGIGREMDVPYRATIMEPLGKMNAYFPIVNEHIAKRNKKLLDFDSARSKARKLTEKPSDDPTKLPKAQQELDDAREVFEMLNGQLVAEIPQLLDQRVPYFDPSFEAMIRMQCKFAEEGYEKLSSVQRYFDDSVRDDYAAGQLDAQVEGVLQEMRELSICGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5H4</accession>
    <name>W4K5H4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytoplasmic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_154870</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW80615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547342.1">
        <property type="nucleotide sequence ID" value="XM_009549047.1"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K5H4"/>
    <dbReference type="GeneID" id="20667530"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_154870"/>
    <dbReference type="eggNOG" id="KOG1998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000595_3_0_1"/>
    <dbReference type="InParanoid" id="W4K5H4"/>
    <dbReference type="OrthoDB" id="18896at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08679">
        <property type="entry name" value="C2_DOCK180_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11684">
        <property type="entry name" value="DHR2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.350">
        <property type="entry name" value="Dedicator of cytokinesis N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042455">
        <property type="entry name" value="DOCK_N_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16172">
        <property type="entry name" value="DOCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 DOCK-type" evidence="8">
        <location>
            <begin position="671"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="9">
        <location>
            <begin position="1594"/>
            <end position="2005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2033"/>
            <end position="2080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2094"/>
            <end position="2116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1874"/>
            <end position="1901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="522"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2034"/>
            <end position="2045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW80615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2164" mass="241873" checksum="CE69B78C357451C0" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4K5W8</accession>
    <name>W4K5W8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_319450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547870.1">
        <property type="nucleotide sequence ID" value="XM_009549575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K5W8"/>
    <dbReference type="FunCoup" id="W4K5W8">
        <property type="interactions" value="168"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K5W8"/>
    <dbReference type="GeneID" id="20670597"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_319450"/>
    <dbReference type="eggNOG" id="ENOG502S5RN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043161_0_0_1"/>
    <dbReference type="InParanoid" id="W4K5W8"/>
    <dbReference type="OrthoDB" id="62853at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="15"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW81208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="398" mass="44523" checksum="866ECD1D78045EF7" modified="2014-03-19" version="1">MSKKAKTPKETKYDFRDVVLAKVRGYPPWPGMVVDPENVTSEVAKERPANKKSHFYCVRFFPKGEHAWLVSKDISRLQQHEIEAYINEPYKKSGDLLTGYRIALDPTKWEEELENKRVEAAEAEENAEVDQLEAESSVADADADADEDDKPIKPKKRKRDSEPAPSKVKGKPKSKKASAEPAGKKKPAAGAKGKKNGAKSKAMVESEDEADPEAVKVREWRHRLQKTFLTDGKDPKPEDMPACDELFTAIEQYEKMNIHYLLFSKIGKVMRHIYMQTPEKIPRDDDFHFRDRANVLVEKWHALMNANKDSVENGTAKVNGAVIKDAPSSEEPKASEPNVTAESEVKRETAEDVPMEDVEAKENTDDVVPKTETNGVAESAETADGDLSVLADVTMSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>W4K661</accession>
    <name>W4K661_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_64667</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545878.1">
        <property type="nucleotide sequence ID" value="XM_009547583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K661"/>
    <dbReference type="FunCoup" id="W4K661">
        <property type="interactions" value="74"/>
    </dbReference>
    <dbReference type="GeneID" id="20678690"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_64667"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_1_1"/>
    <dbReference type="InParanoid" id="W4K661"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF85">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G00710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="8"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW81273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="461" mass="50822" checksum="3F5464D6F3963B0F" modified="2014-03-19" version="1">MTKIDLMIIPLVGVIYFLSFLDRANIGNARIAGLQKDLNMTDHQFSVSLTVFYVSYILTEVPVNLVLKRFGANITIPLMVVLWGLFCACQGSVTTFGGLIACRFFLGMAEGGLFPSLVLYLSNFYPRHSLQLRLSMTFSVTSLAGAFSGLLAAAIEDMDGLRGLSGWAWIFVLEGVLTVLCGILSFFLLPREPSKLRWLTRHEKAVYVEMLREDWSGDAEDEKFSWAEVWSVFLNAPHFIILCVHFFVGGITLFGLATFTPTIVNALSFSTTRSQLLTVPPFACSFVTSLVSAYLSDKYKRRGVTALVFSFLAILGYAIFIGTPNKHANYGALFLQIIGVYGLAPCTATWNANNVQPHFRRATAIAFASACTNVGGIVSTWIFIDPPRFHTASAVNVSFATGNVLACGGLIVYLVRRNAAKRAHVAVLLREKGDGTEKGGWDSPEERQRLGDRHPRFVYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6G4</accession>
    <name>W4K6G4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 56</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_383737</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 60S ribosomal subunit synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_009547748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6G4"/>
    <dbReference type="FunCoup" id="W4K6G4">
        <property type="interactions" value="865"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K6G4"/>
    <dbReference type="GeneID" id="20672167"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_383737"/>
    <dbReference type="eggNOG" id="KOG2573">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015495_4_1_1"/>
    <dbReference type="InParanoid" id="W4K6G4"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000001">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000002">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="8">
        <location>
            <begin position="294"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="443"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="478"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="492"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="513"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW81393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="534" mass="59055" checksum="D9F757EB6D27FD57" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4K6P0</accession>
    <name>W4K6P0_HETIT</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_102072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009547692.1">
        <property type="nucleotide sequence ID" value="XM_009549397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K6P0"/>
    <dbReference type="GeneID" id="20665820"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_102072"/>
    <dbReference type="HOGENOM" id="CLU_420939_0_0_1"/>
    <dbReference type="InParanoid" id="W4K6P0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW81010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="651" mass="70809" checksum="18C731A2683D767E" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4K777</accession>
    <name>W4K777_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_64983</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545897.1">
        <property type="nucleotide sequence ID" value="XM_009547602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K777"/>
    <dbReference type="FunCoup" id="W4K777">
        <property type="interactions" value="589"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K777"/>
    <dbReference type="GeneID" id="20678709"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_64983"/>
    <dbReference type="eggNOG" id="KOG3090">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047969_0_2_1"/>
    <dbReference type="InParanoid" id="W4K777"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF1">
        <property type="entry name" value="PROHIBITIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="7">
        <location>
            <begin position="51"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW81687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="306" mass="33603" checksum="522FA7221D1CEF4C" modified="2014-03-19" version="1">MSNQEAFRRFAQQLQKAGSGGSFPGGNPKGLFAGGGLVLALIAGGITLNASLFNVDGGHRAIKYTRLHGVTEDVYSEGTHLMIPWFETPILFDIRAKPRSIASLTGTKDLQMVNITCRVLSKPSPQALPTIYRELGQDFDERVLPSIVNEVLKSVVAQFNASQLITQREMVSRLVRENLTRRALRFNLVLDDVSITHVAFSPEFTHAVEAKQVAQQTAFRAAFLVDQAIQEKQSIIVRAQGEAKSAELIGEAIRTNKGFLSLRRLEAARDIASLLAASGNRVMLDSDSLLLNVTKDDMKDLLKTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7B6</accession>
    <name>W4K7B6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HETIRDRAFT_51402</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRP40 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545842.1">
        <property type="nucleotide sequence ID" value="XM_009547547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7B6"/>
    <dbReference type="FunCoup" id="W4K7B6">
        <property type="interactions" value="402"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K7B6"/>
    <dbReference type="GeneID" id="20678180"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_51402"/>
    <dbReference type="eggNOG" id="KOG1004">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069847_1_0_1"/>
    <dbReference type="InParanoid" id="W4K7B6"/>
    <dbReference type="OrthoDB" id="340500at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22526">
        <property type="entry name" value="KH-I_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05790">
        <property type="entry name" value="S1_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000112">
        <property type="entry name" value="Exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049469">
        <property type="entry name" value="RRP40_KH-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041054">
        <property type="entry name" value="Rrp40_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037319">
        <property type="entry name" value="Rrp40_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18311">
        <property type="entry name" value="Rrp40_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21262">
        <property type="entry name" value="RRP40_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exosome complex exonuclease Rrp40 N-terminal" evidence="11">
        <location>
            <begin position="17"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="10">
        <location>
            <begin position="149"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ETW81693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="230" mass="24939" checksum="ECE4CC4282AB6EC3" modified="2014-03-19" version="1">MALVLPGESVPVQHVNLKLGPGLQQTITPEGSNVVVSTRAGRLEHSKNGARWWVESNARRYTPALQESVVGIVAGKQGEGWRVDIGSAHNASLDGLAFEGASRRNRPNLKVGSLIYARVSLAHKDMEPELECFDAQTRKAEGFGELKGGLLVRCSLKMARNLLDPSYFLLSLLGSHFPLDVAVGVNGRVWIKANEVRDTIAVTRCIEAADPDEGGLDEAALKQFLKTMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>W4K7W9</accession>
    <name>W4K7W9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tridomain enzyme adenylation-thiolation-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nps8</name>
        <name evidence="4" type="ORF">HETIRDRAFT_45017</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925459">
        <property type="protein sequence ID" value="ETW81166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546913.1">
        <property type="nucleotide sequence ID" value="XM_009548618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K7W9"/>
    <dbReference type="STRING" id="747525.W4K7W9"/>
    <dbReference type="GeneID" id="20676008"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_45017"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002220_1_0_1"/>
    <dbReference type="InParanoid" id="W4K7W9"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
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        <property type="entry name" value="PP-bd_ACP"/>
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        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
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    </dbReference>
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        <property type="entry name" value="AMP-binding"/>
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    </dbReference>
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        <property type="entry name" value="AMP-binding_C_3"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="564"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW81166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1069" mass="117796" checksum="2EE7BAC04A63B156" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4K801</accession>
    <name>W4K801_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_51081</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545831.1">
        <property type="nucleotide sequence ID" value="XM_009547536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K801"/>
    <dbReference type="GeneID" id="20678168"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_51081"/>
    <dbReference type="eggNOG" id="KOG0253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_52_3_1"/>
    <dbReference type="InParanoid" id="W4K801"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="527"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="18"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="288"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW81874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="562" mass="60683" checksum="820333C28DC97389" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8G8</accession>
    <name>W4K8G8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HETIRDRAFT_51505</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW81346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545844.1">
        <property type="nucleotide sequence ID" value="XM_009547549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8G8"/>
    <dbReference type="FunCoup" id="W4K8G8">
        <property type="interactions" value="334"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K8G8"/>
    <dbReference type="GeneID" id="20678182"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_51505"/>
    <dbReference type="eggNOG" id="KOG4628">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028987_0_0_1"/>
    <dbReference type="InParanoid" id="W4K8G8"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000388">
        <property type="entry name" value="Putative RING zinc finger domain superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051653">
        <property type="entry name" value="E3_ligase_sorting_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168:SF1">
        <property type="entry name" value="OS02G0798600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168">
        <property type="entry name" value="RING ZINC FINGER DOMAIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844071" description="RING-type E3 ubiquitin transferase" evidence="13">
        <location>
            <begin position="21"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="341"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETW81346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="432" mass="47232" checksum="214D7DE7419B00F3" modified="2014-03-19" version="1">MHRLDISLSLLIFFALGAHAGPLGWLRAASASVQADHGWLWGWAWGADSSVSVVDRTPPLTFISRPAAFGSELTDPLLGYVIPLNSFTAPCTDVEDANEFALNFTSQAPTSNVGCPALCISGPNVPEASESWIALVQRGKCQFADKAREAQRLGARAVVVGGDDPEISGNPDALVNMYSPGDASDVRIAATFIKYSDYMELSSLIATSNTSHSGLKTLSLLLNSEYSVWQWYSPILTFLTILVVPCCLTFMTLLIHRIRLVRAAQRDRAPEDIVKSLPWRVWTGTGWEKHSGVVPGQDAQPAPSHQDVDIELRESPAESVTPARVVDDDDDPAWFQSQSECAICLEEFMKGDRVRVLPCKHIFHLDEVDAWLIHRKKLCPVCKADVTQPPPVIYSHTPSPLAENTPVAHPASPPIDSMLEATERTPLMQSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4K8Z5</accession>
    <name>W4K8Z5_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_101254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009546820.1">
        <property type="nucleotide sequence ID" value="XM_009548525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K8Z5"/>
    <dbReference type="GeneID" id="20665752"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_101254"/>
    <dbReference type="HOGENOM" id="CLU_2223605_0_0_1"/>
    <dbReference type="InParanoid" id="W4K8Z5"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="106" mass="12014" checksum="0160019948C4BAA8" modified="2014-03-19" version="1">MSFIHPFHAVIVLGIKQGRICGGSQDIDMVRATEELESWASAIQRNEDMTSLKTGRREHHSTVLHDSMRAIRTIFSYEWAANESSAERSEDERSPDESLTSRIHDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4K916</accession>
    <name>W4K916_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Geranylgeranyl pyrophosphate synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_45250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545804.1">
        <property type="nucleotide sequence ID" value="XM_009547509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K916"/>
    <dbReference type="STRING" id="747525.W4K916"/>
    <dbReference type="GeneID" id="20676263"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_45250"/>
    <dbReference type="eggNOG" id="ENOG502QRQN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030046_0_1_1"/>
    <dbReference type="InParanoid" id="W4K916"/>
    <dbReference type="OrthoDB" id="420564at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF2">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW82249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="47354" checksum="92B36275E7515129" modified="2014-03-19" version="1">MYYQHPHLSPLRPAAFRHSSSLGLPPDRHIKEGLDVTRPLHTLLVPPVPTLTSSTSTDIKHYKYIGSYNWTETSYPAVIIVPGSAPEWTGRSPPIKVTPDRGVQFVDQNGFRCPSSILLPLFRSVDTLGKTVDWPAIDFVTDRNGLRKLSRWISGGDVKDFRIDMELAGEHTVLLNRWEAQTRTTFLGKSYGFGFEQATTAAVPGCEKSTGHHRIVKFKFFGLNMVVRYEVDACLPSAPPKIPASRASQSSNPDDLADALAGLNITSSKPANTLAVTSPPSPHASSALPPLLRIVRAGAEQPQESIIELTTRSENYIHKLNWAEIFPQLYLSQTPHFYTGVHSAGRFFEVREQRLDSLEMVSQREKAETGLRKLGKVLKMIQEIVVKHGKAGRLSLVCEDGTLKVYERVSMQSCLPAEVMRRFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9I5</accession>
    <name>W4K9I5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_165304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544856.1">
        <property type="nucleotide sequence ID" value="XM_009546561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9I5"/>
    <dbReference type="GeneID" id="20667975"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_165304"/>
    <dbReference type="HOGENOM" id="CLU_637872_0_0_1"/>
    <dbReference type="InParanoid" id="W4K9I5"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="380"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW82497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="430" mass="47531" checksum="C71F489F2351AF51" modified="2014-03-19" version="1">MQASQSDSTLASWNQTDVGSEQAFVNYGSEPYQSSSGDGLASFPYSIISSQNTEILNLVGCNPSRYSHYSPDEHEFYQMHGAYHHPGGVDFAATADMHYGNTSSHTDLSAAVDVCQDPILDPWAETTHERWNDAVDDVYPAIEPIQVREIVAPTPRHAVQMMLEAAPSSGRRPSVSALNPAFFDQHAWVKERRNRHSLASFHGESAYTENKYEHTSSLLEDEASEKHYQAQYQRRHDHQNAVMPWQGGAANTSANQCFSPCEHSQHYPYSSPSSVTVSPTSAPTASTSPHSQSPVAISILESKFYTILSEQCAPTTHTHTAHAKHEAGIFRGPNTGNQQGLTGRTSTESLETVCEEGSRTASVAQRRGRTRVVRNVQPIACFFCRGRKIACGPADPNSSDKTCMQCLKRHRKCVYPPESRRGRRQNEDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>W4K9Z1</accession>
    <name>W4K9Z1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNase P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RNase_P_6</name>
        <name evidence="9" type="ORF">HETIRDRAFT_57646</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544674.1">
        <property type="nucleotide sequence ID" value="XM_009546379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4K9Z1"/>
    <dbReference type="FunCoup" id="W4K9Z1">
        <property type="interactions" value="282"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4K9Z1"/>
    <dbReference type="GeneID" id="20678403"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_57646"/>
    <dbReference type="eggNOG" id="KOG4046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078577_1_0_1"/>
    <dbReference type="InParanoid" id="W4K9Z1"/>
    <dbReference type="OrthoDB" id="124041at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="entry name" value="Ribonuclease P/MRP, subunit p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00754">
        <property type="entry name" value="RNase_P_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016848">
        <property type="entry name" value="RNase_P/MRP_Rpp29-subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023538">
        <property type="entry name" value="RNP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027081">
        <property type="entry name" value="RNase_P/MRP_p29_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="Rof/RNase P subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW82598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="225" mass="25319" checksum="27A96BFAC298A957" modified="2014-03-19" version="1" fragment="single">YHERIRHQFILLENPEKKGRIALLHAAQVEKMKKAKEWRRLGVIGRNEVVEKGMWKLKKEQERWDLFIPLRRLWLGYMSELLGLASPPASGMPSSAGMHAKLVKADFHGSIMTVRRSNKPALIGLSGIVVHETENAFRVVTRTNKSKLIPKHGSVFAFAVPLYSTLDTPSSSSPAAGPSSSQSSKTSNTVLEAPHIEFELYGNQFQFRSAERASKKFKPKETIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4KA71</accession>
    <name>W4KA71_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_14942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544595.1">
        <property type="nucleotide sequence ID" value="XM_009546300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KA71"/>
    <dbReference type="GeneID" id="20667345"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_14942"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_22_0_1"/>
    <dbReference type="InParanoid" id="W4KA71"/>
    <dbReference type="OrthoDB" id="444848at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48475">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48475:SF1">
        <property type="entry name" value="RNASE H TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW82644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="223" mass="25838" checksum="B84F0FF34D8257F3" modified="2014-03-19" version="1" fragment="single">GAFKLLLERMGIPQITISPYNSKANGVVERGHFIIRESIVKACEGNIAKWPEKVQEAFFADKITISKVTGFSPYYLLHRVHPVLPFDLTESTFLVKGFKSGMSRADLLTLRMRQIQKRQTDLDRAAAQLTKFRIRSKEKFEKKFQKRMQFGPFDPGDLVLVRHTEIEKSLDRKAKPRYRGPYQIVRRNQGGAYILSELSGEIMREKYAAFRILPYIARDRKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KAG9</accession>
    <name>W4KAG9_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_45747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925458">
        <property type="protein sequence ID" value="ETW82086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545811.1">
        <property type="nucleotide sequence ID" value="XM_009547516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KAG9"/>
    <dbReference type="GeneID" id="20676837"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_45747"/>
    <dbReference type="HOGENOM" id="CLU_000384_42_9_1"/>
    <dbReference type="InParanoid" id="W4KAG9"/>
    <dbReference type="OrthoDB" id="1750432at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="10338" checksum="3D234A8E2CCA8A4D" modified="2014-03-19" version="1">MYFLLMNVNTRYNNALIEPKSRKLAAFIINLGMYKPLVIFFRLTNFLATFQIMINALFKDLIYIKKMTIYMDNILVFSKTMENYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KBJ0</accession>
    <name>W4KBJ0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_408790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544790.1">
        <property type="nucleotide sequence ID" value="XM_009546495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KBJ0"/>
    <dbReference type="GeneID" id="20672724"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_408790"/>
    <dbReference type="eggNOG" id="ENOG502T29H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2365241_0_0_1"/>
    <dbReference type="InParanoid" id="W4KBJ0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="96" mass="10557" checksum="E266C78807377CAF" modified="2014-03-19" version="1" fragment="single">MSCSSGKLSTSQQLPALPPTPLQQEDGIFMSTLPCATQQPPISLAQHNIKVRDFAYESVLPPIPPIPRLRSVQAGPRPLKRLKRSHGPDMDDDDPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4KC18</accession>
    <name>W4KC18_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_149167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW82626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544973.1">
        <property type="nucleotide sequence ID" value="XM_009546678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KC18"/>
    <dbReference type="GeneID" id="20667325"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_149167"/>
    <dbReference type="HOGENOM" id="CLU_1124675_0_0_1"/>
    <dbReference type="InParanoid" id="W4KC18"/>
    <dbReference type="OrthoDB" id="10627109at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW82626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="247" mass="26912" checksum="D103B24CCC461B7F" modified="2014-03-19" version="1">MIPGDYSNLFFSGLRVMAHTRRRVPSIPSAPSASSLSSIPSSPETDPASSSFRVRALKSLFQSMRRTPSKAPTSTHGPGAAEPSLHEKKAARRRTLPAATAAPADVFSVWIGEKSPLAQGSTAAVLHTHIEEEDPRPKTGALDPSSPSRSFVITLTEQHPPIPALAKDDDFLSFSASSTHDSPRRLRERPVSLPVPICLPSHPYRMSEHKYSDSTDSADAISCELANTDDWRQFHVEWIGREMVPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4KC83</accession>
    <name>W4KC83_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aspartic peptidase DDI1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_58241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544692.1">
        <property type="nucleotide sequence ID" value="XM_009546397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KC83"/>
    <dbReference type="STRING" id="747525.W4KC83"/>
    <dbReference type="GeneID" id="20678427"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_58241"/>
    <dbReference type="eggNOG" id="ENOG502SRIE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003921_0_0_1"/>
    <dbReference type="InParanoid" id="W4KC83"/>
    <dbReference type="OrthoDB" id="3260546at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW83378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="32531" checksum="815CFCF58C9297B3" modified="2014-03-19" version="1">MGAPAKIPSAKKDAPAYKTTAPIYDEKVAAEVYNRAMATQVTLTQRELLSLSAEVRSQVREATSARRSPTKDASNVRTFYQDADLPYAIDDLEPPTRPTVSSFVNVLHQPETPPPGAIIIPDTYETYLKSLQPGQVPLPLIVAKESSALRSIVPLVDHQQEVECVIDPGSQVIAMSEGICNELALIYDPEIVLNMQSANGEIDRSLGLARNVPFLIGDITLYLQVHIIRNPAYDVLLGRPFDILTESIVKNYSNEDQTITISDPNMGRRATIPTIRRGPPRVLHRRQAGFCDSMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4KC95</accession>
    <name>W4KC95_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_149225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545644.1">
        <property type="nucleotide sequence ID" value="XM_009547349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KC95"/>
    <dbReference type="GeneID" id="20667330"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_149225"/>
    <dbReference type="HOGENOM" id="CLU_2740325_0_0_1"/>
    <dbReference type="InParanoid" id="W4KC95"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW83388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="71" mass="7826" checksum="0C3ECE6D03050CB4" modified="2014-03-19" version="1">MHLSSSCAPLRTSTVFTYACSDNCAQLQKYIQGVHVDTRPRTPSHARCALTNVKIAHIAVALSRPYRSQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KCH7</accession>
    <name>W4KCH7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_426692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545687.1">
        <property type="nucleotide sequence ID" value="XM_009547392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KCH7"/>
    <dbReference type="GeneID" id="20674137"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_426692"/>
    <dbReference type="HOGENOM" id="CLU_653932_0_0_1"/>
    <dbReference type="InParanoid" id="W4KCH7"/>
    <dbReference type="OrthoDB" id="5569250at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW83439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="420" mass="46724" checksum="B946FF4EDC72760C" modified="2014-03-19" version="1">MPLAPEPEPPPQARRSKPVALATHTYHRGMHILVIIGQLPRGVTVKTKKWWRFLSGVVLVLLAAAQAVVPALQCKTFAWSSILPLIELKACETISNLPPAAYLKARRLSVPAIQCRLYGVAMLLQRPSFSCPGSDDVMWIWWCNRQGAIQTEGIDFVHDLPHFLILLFALQRFELDNWWFNISLDQQPHAIHSSDPASRGIGIGSTRYIKLMVLRASGKLARNHNQYELAGASGVWPGWAMHCSGKVESSGNSPVAGGATVASKLSTELQEVTVKIYWQEELRSYQAEGPREASMMGFKMDALGHHPDPLFTHITTLVSTAFMKAWLDCVHTAGVEGQGRYALWELGIEDVKPRLSILMAGKGGHGFLINWELATMFGQSSHDGTSHLETVPFTVLYLLDEEYWASKIKHQYNHGLKGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDG7</accession>
    <name>W4KDG7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF1793-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_449514</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543632.1">
        <property type="nucleotide sequence ID" value="XM_009545337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDG7"/>
    <dbReference type="STRING" id="747525.W4KDG7"/>
    <dbReference type="GeneID" id="20675954"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_449514"/>
    <dbReference type="eggNOG" id="ENOG502QPQS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008020_1_0_1"/>
    <dbReference type="InParanoid" id="W4KDG7"/>
    <dbReference type="OrthoDB" id="3918848at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="GtaA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF1">
        <property type="entry name" value="GLUTAMINASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004844228" description="DUF1793-domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="3">
        <location>
            <begin position="104"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="2">
        <location>
            <begin position="340"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW83902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="698" mass="74955" checksum="BFB9A5518457334D" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4KDN8</accession>
    <name>W4KDN8_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_457952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543692.1">
        <property type="nucleotide sequence ID" value="XM_009545397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KDN8"/>
    <dbReference type="GeneID" id="20676874"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_457952"/>
    <dbReference type="eggNOG" id="ENOG502SJNW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_548729_0_0_1"/>
    <dbReference type="InParanoid" id="W4KDN8"/>
    <dbReference type="OrthoDB" id="3363734at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="53570" checksum="D1AB32BF45E53D1F" modified="2014-03-19" version="1">MLATQRSHSSRHAPISYPLSPQNSPPQGLDSHSPMSAKTTTRHPRRPSLSSPMSWLSRNSSSASQHAPYTPAAKPVRISEPKLSKTVDSLAHIRNRSLGTGAVVVRTPQEALAGSGVTVDVASDPELQEQDSEDSDIPEEEEEEAESNVVHLNSPPSSPSLPPLPISKSSPTLPLRESPTQPAKPSRPPPPAPASTDSSPRSSLKHRSPSPIPSFFPGVPPLPAHLALPPPPPPPPFDCILLSSVPTNAIDMSKMIVTLETCTATHRTTLTTLTSRPSHLANYLKSLFRSYRDSAASLQSQTSEYASSPDTAFNSIFHQHLASSGLLPQSATNVHLFLDRPSAPYDHILTYLRSPPATIDHVPALPHAVQLHTITTPRIEALVALRDEARYLGLDDLHKLCVDELRTRPATRIRGGSIRSTHTVRDQLSPRSSHESARDTGSPSRSGGGGGAIDARRTSPSDLAAALHHRLAGREQGGELKREGSVAHSARSRPVGNWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4KE26</accession>
    <name>W4KE26_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_449272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543349.1">
        <property type="nucleotide sequence ID" value="XM_009545054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KE26"/>
    <dbReference type="GeneID" id="20675930"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_449272"/>
    <dbReference type="HOGENOM" id="CLU_1816047_0_0_1"/>
    <dbReference type="InParanoid" id="W4KE26"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW83570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="142" mass="15333" checksum="7E7451A080571A04" modified="2014-03-19" version="1">MDQRVLWLIHDDDRALAASYNFNPPPPPPRCFPAILAHHPPFLSLPTQGTSTVLMCGAPGHPVIQPYALLISEIFRLVSPQLHQLTTTVPCATATAIQITSTPEPPAVVLHAHRAVVLRARVARAQRPVALPLMATTLPTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEJ5</accession>
    <name>W4KEJ5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HETIRDRAFT_153422</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">TC 32-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="4"/>
    <dbReference type="EMBL" id="KI925457">
        <property type="protein sequence ID" value="ETW83486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009545732.1">
        <property type="nucleotide sequence ID" value="XM_009547437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEJ5"/>
    <dbReference type="STRING" id="747525.W4KEJ5"/>
    <dbReference type="GeneID" id="20667431"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_153422"/>
    <dbReference type="eggNOG" id="ENOG502QVA9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032232_0_0_1"/>
    <dbReference type="InParanoid" id="W4KEJ5"/>
    <dbReference type="OrthoDB" id="406631at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF39">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26410">
        <property type="entry name" value="GH5_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="9">
        <location>
            <begin position="142"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ETW83486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="505" mass="55380" checksum="C139EB365F1110D1" modified="2014-03-19" version="1">MRASCAVRGFPADHESRVTSGGTSRRFIVAQSPSSVGGIYKVLLYGEEYTDEPFQHLRSMRTTAWLSIFSFAVCVSAVVPLPRELWERTGIPQAEIESILSQLPEVPGLGPSASTCTANTTIDGTWPNPTRSSSYDISKRSAFVKRSGNQLTLLGDPFHVVGPNVYWLGLDENVIPDPSYPSKTRVLEAMGVISAMQGTALRGHTLGISFGNPLSVEPSLDVFNENAYESIDFAILAARVYGLKILIPLVDNYNYYHGGKYQFIQWAGHPFEGVGDNITPPDVGAYFFNTSSIVDSFKRYITHHLSHVNRYTNIALKDDPTILGWESGNELSAVLWNDGPAPPTWTSEIGQLIKSLAPNHLFFDGTYGIYEGTGQVDVKVVDVFSDHFYPPNITKLESGIALAHGAGRGYFAGEFDWVGKSGDDLTTFLSQVKTSGAVGDAFWSLFGHDDQCCQYVEHDDGESFYYLRNETYKARGDILVAHAKDISGKQAPAILPAVACPQYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4KEM4</accession>
    <name>W4KEM4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_155391</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543895.1">
        <property type="nucleotide sequence ID" value="XM_009545600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KEM4"/>
    <dbReference type="FunCoup" id="W4KEM4">
        <property type="interactions" value="191"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KEM4"/>
    <dbReference type="GeneID" id="20667569"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_155391"/>
    <dbReference type="eggNOG" id="KOG4155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_11_1"/>
    <dbReference type="InParanoid" id="W4KEM4"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="16"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="57"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="194"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="244"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW84199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="328" mass="34694" checksum="2618D058ADF10BBD" modified="2014-03-19" version="1">MNEAWIESACEPTRHPKSHSDAVWDIAWTANDSVVSVSADGSLKQWDSDSGQVLRIPPTHTLGLVSLSVSPSGKHALYNTIDGSTCLWDLESGEVVGQHEGYARGGTETTETAWSVSLDPKGGSYASTGGSGNITIHSAQLDSFGQRLSTLSSGRNKFGMHCRYSPDGSRIALATESGQMYVYDIQSSALIATYTSHAMAVRSLAWSPDSQFLLSASEDKRLVLHDIRSSSSSGKPGSGAVASLSGHSSWVLSTDISPDGRLALSGSADKTIRVWDLSARAAVSVVQDTGEVWSVSWRPRPSSNNSAGAFVSGGEDGLVRWWRAAGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4KET4</accession>
    <name>W4KET4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_408124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW83810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543556.1">
        <property type="nucleotide sequence ID" value="XM_009545261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KET4"/>
    <dbReference type="GeneID" id="20672661"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_408124"/>
    <dbReference type="HOGENOM" id="CLU_1896484_0_0_1"/>
    <dbReference type="InParanoid" id="W4KET4"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW83810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="134" mass="14509" checksum="8469CB040B805924" modified="2014-03-19" version="1">MVRFLDNQLLIATLHLLVPIPDTLPQAVHALTPSSISRSCANPSLRGISIPDSKNRALGARYITQRIVSGVPATSLSHRLYRACARQHSARDVPALADCMGSRRQARNHGTVAAHHSPRAATDLTWVSDPQPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4KF33</accession>
    <name>W4KF33_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_313683</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544008.1">
        <property type="nucleotide sequence ID" value="XM_009545713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KF33"/>
    <dbReference type="STRING" id="747525.W4KF33"/>
    <dbReference type="GeneID" id="20670053"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_313683"/>
    <dbReference type="eggNOG" id="ENOG502SK3A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036940_0_1_1"/>
    <dbReference type="InParanoid" id="W4KF33"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF3">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="89"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="292"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ETW84324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="334" mass="37297" checksum="0B909DB4A4673C90" modified="2014-03-19" version="1">MLAVPRQSLHSDYAHHRRYRLYALLKPWLPLIVYLLTSLGFLLTIAVWKEEVFKGLDDLSSWLKADERFGYAVLFFLIFLTTFPPLPLYSTLIILSGYTFGPWTGALISYSAALAGALVVFILSRYLFHETISRWLSCAVSVKRVVRAIEKRPKLLFLIRLAPYPYNVMNCLLAASPTLTLRTYAVCTALSLFKVIIHTALGNSIHSFAAYHVKPRPEAAEQDESALAHYSTIGGIVLCVGIFIYLSYVARRAVDEELEDETLPAHTDEEARAFLPRDVDSLSLHGHMSETPFRAATPSTVSATGGSTLWSTSRTDTGTGREWGGREEAEIGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFP4</accession>
    <name>W4KFP4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HETIRDRAFT_155557</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544206.1">
        <property type="nucleotide sequence ID" value="XM_009545911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFP4"/>
    <dbReference type="GeneID" id="20667581"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_155557"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_5_1"/>
    <dbReference type="InParanoid" id="W4KFP4"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033229">
        <property type="term" value="F:cysteine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="54"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ETW84549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="489" mass="54826" checksum="9EFD0F02A82F9404" modified="2014-03-19" version="1">MSALDKDSHEPSVQIEDTDKDVYSFRSASPGTDGVPEIDDATNRRLRWMIHKRVLVVMVVTYFAQTLDKGTINFASIMGIRTDTNLHGQQYAWLTTCVYIAILCWEFPANRLLQRLPVAKLLAFNITAWGAILACTAACKNFTGLVIVRTLLGMFECICQPAFVFMSTMWYTREEQALVIGAFYSMNGFQQCVGGLIAYGIAHIEHARLKNWQVLFTLLGCVTALWGIFVLWWLPDSPMRARCFSKEDRLLMAERVRKNETGIQNKEFKALTDPNVWAVTLISLTNALPTGGLGAFSNIILNAFGFTQLQTYLLAIAQGAIIMIFLFSGAYLSKRYNQKLLFAFLYTLPNIAGTIVFLSKQESLCTQGFGAVAVLNLAVMSGNVAGRTKQVIASTLVFVAWAVGNAVGPQVFRANDAPRYIKAFIAHMVVYGVQLVVIVTLRLRLMRLNALKRRAQKGFDDAANRERIEHKHAFDDLTDKENPDFRYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFS3</accession>
    <name>W4KFS3_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 monooxygenase 104</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cpm104</name>
        <name evidence="11" type="ORF">HETIRDRAFT_116864</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544331.1">
        <property type="nucleotide sequence ID" value="XM_009546036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFS3"/>
    <dbReference type="STRING" id="747525.W4KFS3"/>
    <dbReference type="GeneID" id="20666520"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_116864"/>
    <dbReference type="eggNOG" id="KOG0158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_5_11_1"/>
    <dbReference type="InParanoid" id="W4KFS3"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ETW84693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="524" mass="57099" checksum="B692871CB6447B10" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>W4KFY0</accession>
    <name>W4KFY0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_171142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544280.1">
        <property type="nucleotide sequence ID" value="XM_009545985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KFY0"/>
    <dbReference type="GeneID" id="20668319"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_171142"/>
    <dbReference type="HOGENOM" id="CLU_3032605_0_0_1"/>
    <dbReference type="InParanoid" id="W4KFY0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW84634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="55" mass="6467" checksum="7002C0542E4749FC" modified="2014-03-19" version="1">MSSGYHDLVIHWNTQTLSHPKNPYKTINNATYYLIDNEVIELLGILLKSEWSLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4KG67</accession>
    <name>W4KG67_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_313126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544365.1">
        <property type="nucleotide sequence ID" value="XM_009546070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KG67"/>
    <dbReference type="GeneID" id="20670006"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_313126"/>
    <dbReference type="HOGENOM" id="CLU_2542833_0_0_1"/>
    <dbReference type="InParanoid" id="W4KG67"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW84729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="83" mass="9313" checksum="B421A4EC619A5FE4" modified="2014-03-19" version="1">MTALIVDITVGSTLDRISATSFCRESRLSNDWSISAPRITIISEKISSARLMLADENIAIVAISITRLNLDFRPFRLEWARVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>W4KG87</accession>
    <name>W4KG87_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_247562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544375.1">
        <property type="nucleotide sequence ID" value="XM_009546080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KG87"/>
    <dbReference type="STRING" id="747525.W4KG87"/>
    <dbReference type="GeneID" id="20669179"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_247562"/>
    <dbReference type="eggNOG" id="KOG2401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2580268_0_0_1"/>
    <dbReference type="InParanoid" id="W4KG87"/>
    <dbReference type="OrthoDB" id="3231855at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053020">
        <property type="entry name" value="Smr_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417:SF1">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="1">
        <location>
            <begin position="6"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW84744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="81" mass="8692" checksum="E89015466A2BA47D" modified="2014-03-19" version="1" fragment="single">RKLNNVDLHGLYVQEATKFAEASITVARSHGFESLKLIVGKGLHASNGVAKVKPAVEKMLKSRGLVVTEQRGNAGVLIVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4KGF5</accession>
    <name>W4KGF5_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Piwi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_314333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925456">
        <property type="protein sequence ID" value="ETW84922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009544543.1">
        <property type="nucleotide sequence ID" value="XM_009546248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KGF5"/>
    <dbReference type="FunCoup" id="W4KGF5">
        <property type="interactions" value="231"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KGF5"/>
    <dbReference type="GeneID" id="20670114"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_314333"/>
    <dbReference type="eggNOG" id="KOG1041">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004544_4_3_1"/>
    <dbReference type="InParanoid" id="W4KGF5"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
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            <begin position="232"/>
            <end position="344"/>
        </location>
    </feature>
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        <location>
            <begin position="527"/>
            <end position="830"/>
        </location>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW84922.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="873" mass="98376" checksum="80B0A70C02AE6D96" modified="2014-03-19" version="1"> </sequence>
</entry>
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    <accession>W4KGU1</accession>
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        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
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    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="BCAS3-like"/>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
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        <property type="entry name" value="BCAS3 MICROTUBULE ASSOCIATED CELL MIGRATION FACTOR"/>
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    </dbReference>
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        <property type="entry name" value="BREAST CARCINOMA AMPLIFIED SEQUENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
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        </location>
    </feature>
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        <location>
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            <end position="40"/>
        </location>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="28"/>
        </location>
    </feature>
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            <end position="188"/>
        </location>
    </feature>
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        <location>
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            <end position="513"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="1138"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF21034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW84929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1217" mass="133330" checksum="8F2AF94F0ED4163C" modified="2014-03-19" version="1"> </sequence>
</entry>
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        <submittedName>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Bondarzewiaceae</taxon>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_42737"/>
    <dbReference type="eggNOG" id="ENOG502SMFS">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049744_1_0_1"/>
    <dbReference type="InParanoid" id="W4KH12"/>
    <dbReference type="OrthoDB" id="3337916at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
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    </dbReference>
    <dbReference type="InterPro" id="IPR048958">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR40124">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40124:SF1">
        <property type="entry name" value="DISAGGREGATASE RELATED REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21294">
        <property type="entry name" value="Polysacc_lyase_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845393" evidence="2">
        <location>
            <begin position="21"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide lyase 14" evidence="3">
        <location>
            <begin position="163"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW85137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="392" mass="40924" checksum="D943C6A155A787A9" modified="2014-03-19" version="1">MYAFNAFVLVLVALFSFANALPLGHGHIRRSCPHNARASALSAIESASSAASSAESTPLSSTVPSSSSSAVPTATSSKAAASHSASAPSSSASSAKATATRSATNNAVTGSLLGALFPIAQPSTSWTTLQGISGALSLSDSTFNPDHVLSSLTHNYVASPGSDSKLSMQAHYPKGSYTFGHQPQGGISFYAPGPSDVDLTTAKEATFGYSVMFDEGFDWNKGGKLPGLYGGDDATVAVSCSGGRRSDACFSARLMWRTDGQGELYTYLPPYTDSRFAANEKQCSVAPKSECNPTYGASVGRGSFSFEAGKWTTVSQRVRLNDVGQANGELELFANGESVVKVDGLILRASDAGRLRGIQMQTFFGGSTSDWASPKDQNTYFSDFSMAITEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>W4KH27</accession>
    <name>W4KH27_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone deacetylase complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_414162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541915.1">
        <property type="nucleotide sequence ID" value="XM_009543620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KH27"/>
    <dbReference type="STRING" id="747525.W4KH27"/>
    <dbReference type="GeneID" id="20673157"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_414162"/>
    <dbReference type="eggNOG" id="KOG3391">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064128_0_0_1"/>
    <dbReference type="InParanoid" id="W4KH27"/>
    <dbReference type="OrthoDB" id="440566at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.550">
        <property type="entry name" value="ASAP complex, SAP18 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010516">
        <property type="entry name" value="SAP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042534">
        <property type="entry name" value="SAP18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082:SF0">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06487">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW85019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="30572" checksum="22BB64499E035193" modified="2014-03-19" version="1">METTTTASGQPIVDREKTVPFLVRAFIKVGGFHRLNQFEEGPLPIADEQQIFTWKDATLSEIITSLRSIAPQTAEYRHPLARFSFRAIFADSASRGRYAQKDLGMVYSRDILGEPGTLDTPAPRLLEDAEDDPSKQKEARTLEELRLVPGDYLCIAVYLPKSVTAAPGPNVELSIKGSSAAAGGANGWKISGPLGPGRDGDGFGPGSGAGRGAGGHWRGGSEAPRGRGGRGGDIGDRDRRPLPARRRRDTPPRNSGWDDVGRDAYRDRSRSRSRSPPRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KI57</accession>
    <name>W4KI57_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_100826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542379.1">
        <property type="nucleotide sequence ID" value="XM_009544084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KI57"/>
    <dbReference type="GeneID" id="20665710"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_100826"/>
    <dbReference type="HOGENOM" id="CLU_2004218_0_0_1"/>
    <dbReference type="InParanoid" id="W4KI57"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004845484" evidence="2">
        <location>
            <begin position="22"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ETW85527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="124" mass="13206" checksum="42D7E35ACE77800F" modified="2014-03-19" version="1">MAFGGLLWMGFVVAVLLSIRAGQDSGLCKDFSRLSGACGGAGPGLVVFALLASWVTPVLASVGIFMHVREGMWHAQKAPLRPLYLSGNREKGPDVETYPAPWNQFDTVPLDDSIPTVSYGHMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIH7</accession>
    <name>W4KIH7_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_457436</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542492.1">
        <property type="nucleotide sequence ID" value="XM_009544197.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="W4KIH7">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KIH7"/>
    <dbReference type="GeneID" id="20676831"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_457436"/>
    <dbReference type="eggNOG" id="KOG0998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006395_0_0_1"/>
    <dbReference type="InParanoid" id="W4KIH7"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd14270">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF170">
        <property type="entry name" value="DYNAMIN ASSOCIATED PROTEIN 160, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
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                <person name="Aerts A."/>
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                <person name="Bouzid O."/>
                <person name="Broberg A."/>
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                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
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                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
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                <person name="Hietala A."/>
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                <person name="James T.Y."/>
                <person name="Karlsson M."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Lucas S."/>
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                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    </evidence>
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</entry>
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                <person name="Cullen D."/>
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                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
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                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
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                <person name="Karlsson M."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
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                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_448712"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0000500">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Rrn5"/>
    </dbReference>
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        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28079:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN5"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="191"/>
        </location>
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            <end position="331"/>
        </location>
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    </feature>
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        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
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        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
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        <location>
            <begin position="568"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="707"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="738"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW85678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="796" mass="88147" checksum="2852D9B64DCC1326" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIL5</accession>
    <name>W4KIL5_HETIT</name>
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        <recommendedName>
            <fullName evidence="8">60S ribosomal protein L7</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">HETIRDRAFT_438386</name>
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    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">TC 32-1</strain>
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        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
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    </dbReference>
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        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_L30_N"/>
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    </dbReference>
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        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="5">
        <location>
            <begin position="15"/>
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        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="4">
        <location>
            <begin position="91"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW85692.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="28889" checksum="513751411C074403" modified="2014-03-19" version="1">MAASTTVPTVSDIEVPETLLKKRKQNEKAREERLVKADAARKAAKAKRKVIFKRAETYVKDYLSKEREEIRLKRAARASGDFYVPAQPKVYFVVRIRGINEIAPKPRKILQLLRLLQINNGVFVRVTKATQQMLRLVEPYVTYGEPNLKTVRELIYKRGYGKVDKQRIPLSNNAVIEESLGKYDILSVEDLVHEIFTVGPNFKQAANFLWPFKLSNPTGGWRIRKFKHYVEGGDFGNREDNINKLIRQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KIM7</accession>
    <name>W4KIM7_HETIT</name>
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        <recommendedName>
            <fullName evidence="13">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542535.1">
        <property type="nucleotide sequence ID" value="XM_009544240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KIM7"/>
    <dbReference type="GeneID" id="20675883"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_448726"/>
    <dbReference type="eggNOG" id="ENOG502S87A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090067_0_0_1"/>
    <dbReference type="InParanoid" id="W4KIM7"/>
    <dbReference type="OrthoDB" id="432881at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08761">
        <property type="entry name" value="Cyt_b561_CYB561D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF45">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="145"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="13">
        <location>
            <begin position="78"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ETW85702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="247" mass="26488" checksum="1DFFA9027CEBB673" modified="2014-03-19" version="1">MSTPDDLPHGYQALPAHPDQSDPLVPAMGNEEQLPKPEGRKGDTLALYAAITAAAIFTVVTWAMVLNNNPSALGWFAFHPTLQSLAIFFFTLGILTLQPTSQPSTKAAGLQRHQIAMLLGVPTIILGALSIIWNKRIHEAPHFTTWHGVFGILSLTWLAAQFALGAASVWFGGAALGGGPRAKRVWKLSGYVLLPLVLATANFGGAWSAWVTSSSAHGVRIVAYTLAPAVILASLYSRIRPSKMRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KK88</accession>
    <name>W4KK88_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_100344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542896.1">
        <property type="nucleotide sequence ID" value="XM_009544601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KK88"/>
    <dbReference type="GeneID" id="20665683"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_100344"/>
    <dbReference type="HOGENOM" id="CLU_1992915_0_0_1"/>
    <dbReference type="InParanoid" id="W4KK88"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="125" mass="13321" checksum="15965F929789A3A6" modified="2014-03-19" version="1">MSPHLDSARPCSAVWEEGASVGTSAAGKHRRFAHAISTSKDVTTPRRRPCTRPTMPRGRDVIAGVTEREPSPSPSRWPAVPSEPAIPSSPPLLKPSIALPYKPPTRAQTCAPPRLPPSLAQVPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKK6</accession>
    <name>W4KKK6_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_101265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009543005.1">
        <property type="nucleotide sequence ID" value="XM_009544710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKK6"/>
    <dbReference type="GeneID" id="20665753"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_101265"/>
    <dbReference type="eggNOG" id="ENOG502RC63">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184646_0_0_1"/>
    <dbReference type="InParanoid" id="W4KKK6"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="70" mass="7463" checksum="0C6F5FC127342861" modified="2014-03-19" version="1">MSSGQQQQQQHQMRLYVAGTDALASGCVCARGVLPDVLVFDSAVPQPDAPPKMYSSNSRPRADAPLPPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKS8</accession>
    <name>W4KKS8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_309437</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW85955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009542753.1">
        <property type="nucleotide sequence ID" value="XM_009544458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKS8"/>
    <dbReference type="STRING" id="747525.W4KKS8"/>
    <dbReference type="GeneID" id="20669678"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_309437"/>
    <dbReference type="eggNOG" id="ENOG502SJA9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096587_0_0_1"/>
    <dbReference type="InParanoid" id="W4KKS8"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW85955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="206" mass="23599" checksum="230F8392CA45F6E7" modified="2014-03-19" version="1">MSSPPPEVVFSNDVRNMDDWAKRTGIPLTSADALGTNYARARRWLLSLKQQLVQRHGWREASPLDSRMLFSIECSPPHRSSSGLPRSPNMRLQIPLNASSFFSPDRRVQWEMVFHSAVFPSMRHTVTPVSDLLHLLQCLLTGLLVLVKVERVPNEGVYRTIRGLPPIEWISSHEQMLTEVFGSAHYRTLFRAASDKRIAFKLEHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4KKS9</accession>
    <name>W4KKS9_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_447220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540479.1">
        <property type="nucleotide sequence ID" value="XM_009542184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KKS9"/>
    <dbReference type="GeneID" id="20675742"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_447220"/>
    <dbReference type="HOGENOM" id="CLU_1886020_0_0_1"/>
    <dbReference type="InParanoid" id="W4KKS9"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="135" mass="13696" checksum="35BBA127389C204F" modified="2014-03-19" version="1">MTANALGFWILHHPSCSSCSSCSSCSSCSSHHFFPATTTPATPTTAPATFTPTPAPSAPAPSTPATPVPTLSTALPHLLVSPPLPLLLHCAGSSAPLAPLLFLLIHCSTALPTTTTPATPADAVDSTLPLYSLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLJ1</accession>
    <name>W4KLJ1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_423730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540577.1">
        <property type="nucleotide sequence ID" value="XM_009542282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLJ1"/>
    <dbReference type="GeneID" id="20673939"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_423730"/>
    <dbReference type="HOGENOM" id="CLU_486657_0_0_1"/>
    <dbReference type="InParanoid" id="W4KLJ1"/>
    <dbReference type="OrthoDB" id="3133596at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="560" mass="62867" checksum="86A2DA1496B3B5A3" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLQ2</accession>
    <name>W4KLQ2_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Quinone oxidoreductase 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">qor9</name>
        <name evidence="2" type="ORF">HETIRDRAFT_31829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925455">
        <property type="protein sequence ID" value="ETW86275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541731.1">
        <property type="nucleotide sequence ID" value="XM_009543436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLQ2"/>
    <dbReference type="STRING" id="747525.W4KLQ2"/>
    <dbReference type="GeneID" id="20670492"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_31829"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_1"/>
    <dbReference type="InParanoid" id="W4KLQ2"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF3">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="27"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW86275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="365" mass="38607" checksum="3173307077E07BB4" modified="2014-03-19" version="1">MSSSLPRTTKALVVQKDAQERKPVYHGTEVVERPIPTLKHGEILVKIGAAAFNHRDLWIRKGQYPGITFGNTLGADGAGIVVASADAADPLLHKRVFLVPMRGWESDPDAPESGAGVSIMGGTKHLAIGTFSEYVAVERDQIILSPDHLDDVQISAWPVGGVTAWRAAMVNARVDKGHNVLITGAGGGVALIALQLCLAKGANVYVTSGSEEKIARAIGLGAKGGVNYKNASWPKELGKLLQRDGQSSLNAVIDSGGGDIARQTGGLLRAGGRVVCYGMTAAPQIAVSMREVLKNQQLIGSTMGSHKDLIDATRFLAEHRIVPIVSHVLDGLQSAEQGFELMKRGEQFGKIVIKVEAKPAPSAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2023-06-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>W4KLY0</accession>
    <name>W4KLY0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_406708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW86838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009540820.1">
        <property type="nucleotide sequence ID" value="XM_009542525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KLY0"/>
    <dbReference type="GeneID" id="20672539"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_406708"/>
    <dbReference type="HOGENOM" id="CLU_2441122_0_0_1"/>
    <dbReference type="InParanoid" id="W4KLY0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW86838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="90" mass="10064" checksum="6965CF6E02F6AA03" modified="2014-03-19" version="1">MGGHLRMRDAQLFGARFWSMASALGDRAQRRAFCCATILLRPFPTSGVFSRDPRLDVVGWLWKALPSEVAIASHFAAADYDLLYLVDQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>W4KMG6</accession>
    <name>W4KMG6_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_181091</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">TC 32-1</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="ENOG502SHUE">
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="378"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="415"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="445"/>
            <end position="466"/>
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            <begin position="1"/>
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            <end position="174"/>
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            <end position="267"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
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        </source>
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        <source>
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        <source>
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    <sequence length="572" mass="62860" checksum="E8855AFD95415ABD" modified="2014-03-19" version="1"> </sequence>
</entry>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
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                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
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                <person name="Durling M."/>
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                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
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                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Yakovlev I."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
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                <person name="Hogberg N."/>
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                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
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                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
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                <person name="Yakovlev I."/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
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    </evidence>
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    </evidence>
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            <dbReference type="Pfam" id="PF00733"/>
        </source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="550" mass="60900" checksum="E710106C44D81646" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KPN7</accession>
    <name>W4KPN7_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_305385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541646.1">
        <property type="nucleotide sequence ID" value="XM_009543351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KPN7"/>
    <dbReference type="GeneID" id="20669323"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_305385"/>
    <dbReference type="HOGENOM" id="CLU_2922870_0_0_1"/>
    <dbReference type="InParanoid" id="W4KPN7"/>
    <dbReference type="OrthoDB" id="3268967at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="61" mass="7184" checksum="10BEB194AD4EEC04" modified="2014-03-19" version="1">MYNSLLLLRSYMVLPDILCLYKCFFCIAHNSLGHFGTNKSYSTLHSSFYWINMCYNTEMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>W4KQ62</accession>
    <name>W4KQ62_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_378607</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541432.1">
        <property type="nucleotide sequence ID" value="XM_009543137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KQ62"/>
    <dbReference type="FunCoup" id="W4KQ62">
        <property type="interactions" value="283"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4KQ62"/>
    <dbReference type="GeneID" id="20671930"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_378607"/>
    <dbReference type="eggNOG" id="KOG1779">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130128_3_0_1"/>
    <dbReference type="InParanoid" id="W4KQ62"/>
    <dbReference type="OrthoDB" id="5567124at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.100:FF:000001">
        <property type="entry name" value="40S ribosomal protein S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_eS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_eS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_eS27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11594">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01168">
        <property type="entry name" value="RIBOSOMAL_S27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW87540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="83" mass="9057" checksum="0CBA6B1FD62B18E9" modified="2014-03-19" version="1">MTLAVDLLNPSAEHEKRSHKLKRLVQSPNSYFMDVKCPGCFAITTVFSHAQTVVICGACASVLCQPTGGKARLTEGSSYRRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4KQ72</accession>
    <name>W4KQ72_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_413862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925454">
        <property type="protein sequence ID" value="ETW87550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009541442.1">
        <property type="nucleotide sequence ID" value="XM_009543147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4KQ72"/>
    <dbReference type="GeneID" id="20673137"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_413862"/>
    <dbReference type="eggNOG" id="ENOG502SH1G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090743_0_0_1"/>
    <dbReference type="InParanoid" id="W4KQ72"/>
    <dbReference type="OrthoDB" id="2537258at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW87550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="251" mass="27384" checksum="9E1D36880C75344C" modified="2014-03-19" version="1">MGSVASPPPHSSDHPAIAEYPPQSLNKPERLISSTWQILEQPPPPSLREILGAYRTRGDGDREMLMAMLNAKSAEDQRIASMASLHRSMLEYYQLVPPSAHQSPNDHPYLESFGAYSHPGLSPQSNGNPSSYSPRINKEPHRSSHTVHPRKRHRTSESPHANHHSVPRAPTPSSPPQLPSSPYSSTRSDSTQHSPHSRSAMDIGSLLSAGAREAAREEAERRGSPRDGIMDRAAPVRGHHSNANSVAVVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4JN42</accession>
    <name>W4JN42_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_332168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553416.1">
        <property type="nucleotide sequence ID" value="XM_009555121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JN42"/>
    <dbReference type="STRING" id="747525.W4JN42"/>
    <dbReference type="GeneID" id="20671708"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_332168"/>
    <dbReference type="HOGENOM" id="CLU_132424_0_0_1"/>
    <dbReference type="InParanoid" id="W4JN42"/>
    <dbReference type="OrthoDB" id="3183767at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW74958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="173" mass="19349" checksum="0C78D7FBF4256F7D" modified="2014-03-19" version="1" fragment="single">HSVAFIPEDDPAAFGFLDPEQIICSVHLIPAFAHEHTSERLGSSITQQPAENDEDWEGYHINMFVDRDMFMHFHGGGIGHKGTWHLNASLLRDGQAAQVPEEPSDEAVDEQGGAEDDDSEEESEEEEGEEGPLMEEEEEEEEEDSDNDPNPLPEGNGRERDERVLAKEGYGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNS4</accession>
    <name>W4JNS4_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_57170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553058.1">
        <property type="nucleotide sequence ID" value="XM_009554763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNS4"/>
    <dbReference type="GeneID" id="20678386"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_57170"/>
    <dbReference type="eggNOG" id="ENOG502S3G3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_32_0_1"/>
    <dbReference type="InParanoid" id="W4JNS4"/>
    <dbReference type="OrthoDB" id="128646at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW74715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="123" mass="14160" checksum="2D607BFDF9914BE9" modified="2014-03-19" version="1" fragment="single">MNDRIITPIRLNVKVSNRSQYAGAKATIDSACEGVIVNKTWVKRHRFPTYTLNNPIRVRNVDDTINKAGLIRSALDVNLTIRDISGRTHTERVQMFISNLGKDDLILGTDWLKYHDPSIEWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>W4JNX4</accession>
    <name>W4JNX4_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TM7S3/TM198-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HETIRDRAFT_456310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553249.1">
        <property type="nucleotide sequence ID" value="XM_009554954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JNX4"/>
    <dbReference type="GeneID" id="20676729"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_456310"/>
    <dbReference type="eggNOG" id="ENOG502SUFN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060789_0_0_1"/>
    <dbReference type="InParanoid" id="W4JNX4"/>
    <dbReference type="OrthoDB" id="3359595at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="TM7S3/TM198-like" evidence="7">
        <location>
            <begin position="59"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ETW74765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="309" mass="32437" checksum="06512BA7D4AC0571" modified="2014-03-19" version="1">MQSALLPRAPAIVKTSESGNTTTVSVFDSNSLQPITQTSASDGSGVGFASSAPSILWFCFCLLFGLPLALAGIRGRRFTTGAAFGLAFGVCSWAAFINTVSAPGIADLPLTLIVFAFVFVGSALGMFSLVRVGGMVTLGVVGGLALGVRIVVVKDDLLVASVFFVNWLVASVFGLLGGLLVVTNRRTGILVCSASAGTFLAGLGADLIVNQQDGLSRGYRFLFDRNTSHLTDLLVHGYHPPVSAQINIAVSISLIPLLAYLQHRLFPNEFSSTRPESVVLNDANLADSEKPRSDARAPLSSEPVSRFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>W4JP69</accession>
    <name>W4JP69_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HETIRDRAFT_127188</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">TC 32-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KI925467">
        <property type="protein sequence ID" value="ETW74686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009553180.1">
        <property type="nucleotide sequence ID" value="XM_009554885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JP69"/>
    <dbReference type="FunCoup" id="W4JP69">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JP69"/>
    <dbReference type="GeneID" id="20666979"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_127188"/>
    <dbReference type="eggNOG" id="KOG0927">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_45_3_1"/>
    <dbReference type="InParanoid" id="W4JP69"/>
    <dbReference type="OrthoDB" id="10255969at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43117">
        <property type="entry name" value="OSMOPROTECTANT IMPORT ATP-BINDING PROTEIN OSMV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43117:SF4">
        <property type="entry name" value="OSMOPROTECTANT IMPORT ATP-BINDING PROTEIN OSMV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="31"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="327"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ETW74686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="582" mass="64511" checksum="10865D774FD1704C" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPD1</accession>
    <name>W4JPD1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Quinone oxidoreductase 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">qor18</name>
        <name evidence="2" type="ORF">HETIRDRAFT_157553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552809.1">
        <property type="nucleotide sequence ID" value="XM_009554514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPD1"/>
    <dbReference type="GeneID" id="20667737"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_157553"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_1_1"/>
    <dbReference type="InParanoid" id="W4JPD1"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="14"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW75388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="349" mass="37457" checksum="091BF9A661319F17" modified="2014-03-19" version="1">MAPSKHLTAVVAEGGSTVVKEVDVPKLGPGQILVKVVAAAQNPTDWKTALWGKRYGSVSGCDFSGVIEELSSDVPASLRSVGDRVAGIVHGGVYPNGAFAEYLVVDAERVLHIPDSWSFEDAAQLGVGPYTAVQCLYQSHSFATPLAPTSTPTPLLIWGGATSVGQYVIQFAKLAGLHVIVTVSPKNFDLVKSLGADEVFDYNDPEVSKKIKLATGGKLAHAVDTISENDTPRQISEALSDDGGRVAALLFYKSPRPEVSINLTLAYDLLGKSYDFPFPWSPKTDEDRDRGKKFTQLLQQIIDTGKIKPNATLILPQGLASVAQGFEYQKTGKVSAQKITYRIADTPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>W4JPQ8</accession>
    <name>W4JPQ8_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HETIRDRAFT_243993</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">TC 32-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KI925466">
        <property type="protein sequence ID" value="ETW75454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552871.1">
        <property type="nucleotide sequence ID" value="XM_009554576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JPQ8"/>
    <dbReference type="STRING" id="747525.W4JPQ8"/>
    <dbReference type="GeneID" id="20669023"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_243993"/>
    <dbReference type="eggNOG" id="ENOG502SGA0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122021_2_1_1"/>
    <dbReference type="InParanoid" id="W4JPQ8"/>
    <dbReference type="OrthoDB" id="202672at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024512">
        <property type="entry name" value="Ser_palmitoyltrfase_ssu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11779">
        <property type="entry name" value="SPT_ssu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ETW75454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="76" mass="9240" checksum="72AFAA657B707254" modified="2014-03-19" version="1" fragment="single">KKPNSMISRVLWQWRLWFEATFVFTLLEPWEKAFLMTLLAVFTTMLVTGLYKYFPYHVAFLYRRGMYYLLGQEGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>W4JR63</accession>
    <name>W4JR63_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_390472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552285.1">
        <property type="nucleotide sequence ID" value="XM_009553990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JR63"/>
    <dbReference type="GeneID" id="20672455"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_390472"/>
    <dbReference type="HOGENOM" id="CLU_2688126_0_0_1"/>
    <dbReference type="InParanoid" id="W4JR63"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="74" mass="8058" checksum="519793B2EB4D7D79" modified="2014-03-19" version="1">MTAWSYLELLVGWANLIFTYTVCAGHAAVLLGCSAPRAELAADLFLLLSVRTLLYRPDDVEIPNSHAIIPCTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRB1</accession>
    <name>W4JRB1_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_222332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009552300.1">
        <property type="nucleotide sequence ID" value="XM_009554005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRB1"/>
    <dbReference type="GeneID" id="20668663"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_222332"/>
    <dbReference type="HOGENOM" id="CLU_126116_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRB1"/>
    <dbReference type="OrthoDB" id="2686513at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="154" mass="17166" checksum="C3E40848ED888F50" modified="2014-03-19" version="1" fragment="single">LIKQHNTVITGEPLHGCHTGLSFMRFIAVPWEGQFLFDVTVFGLTVYKSFQHRSESEWARGKRSWSNLGLMELIFRDGASPTSVHHLVMALVNLANIFTFYLTSDPLRGVLSTFASCVSITMMSRLILNLHDAASLLPSTRATTVPMAFAPPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>W4JRM0</accession>
    <name>W4JRM0_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HETIRDRAFT_430267</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551991.1">
        <property type="nucleotide sequence ID" value="XM_009553696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JRM0"/>
    <dbReference type="STRING" id="747525.W4JRM0"/>
    <dbReference type="GeneID" id="20674434"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_430267"/>
    <dbReference type="eggNOG" id="ENOG502S89P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012917_0_0_1"/>
    <dbReference type="InParanoid" id="W4JRM0"/>
    <dbReference type="OrthoDB" id="5571888at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14810">
        <property type="entry name" value="bZIP_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="378"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="581"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ETW75730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="728" mass="77583" checksum="AA030532586800E4" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>W4JS01</accession>
    <name>W4JS01_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_174386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551232.1">
        <property type="nucleotide sequence ID" value="XM_009552937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JS01"/>
    <dbReference type="GeneID" id="20668510"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_174386"/>
    <dbReference type="eggNOG" id="ENOG502STIY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068522_0_0_1"/>
    <dbReference type="InParanoid" id="W4JS01"/>
    <dbReference type="OrthoDB" id="440424at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038213">
        <property type="entry name" value="IFI6/IFI27-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="260" mass="28663" checksum="DB26AFCB9292887F" modified="2014-03-19" version="1">MFGGYQDIYTSNIPNDFFERAKSMGNVLKKYATGLLDRVNAEYEAPVQAKVAEFRESLDRLAEGTTRLHDLGMSDFGEELARVLATIAQQIQDEFPPPDKAPSHERRVEMVDDVLQRVEEVLVHVAEAYGLPAERIREDLHDRILPHVKRLVVITGDLAEQHPVLLETLLFAAVGALIPESWFLRPLLNLFGFGPYGPVKGSAAAWAQRRFYGATVASRSWFAHLQSAAMRPRLPPGTGAAIGGAVGAGLSLFGCRARAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>W4JS46</accession>
    <name>W4JS46_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein transport protein SEC31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein transport protein sec31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HETIRDRAFT_156866</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW75706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551969.1">
        <property type="nucleotide sequence ID" value="XM_009553674.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="W4JS46">
        <property type="interactions" value="419"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JS46"/>
    <dbReference type="GeneID" id="20667674"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_156866"/>
    <dbReference type="eggNOG" id="KOG0307">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003033_2_0_1"/>
    <dbReference type="InParanoid" id="W4JS46"/>
    <dbReference type="OrthoDB" id="542917at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000193">
        <property type="entry name" value="Protein transport protein SEC31, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009917">
        <property type="entry name" value="SRA1/Sec31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07304">
        <property type="entry name" value="SRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7 15" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="123"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="278"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="SRA1/Sec31" evidence="17">
        <location>
            <begin position="1269"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="524"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1026"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="571"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1037"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1082"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1146"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1207"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1268"/>
            <end position="1281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ETW75706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="1410" mass="150249" checksum="684CD0709E05BCC8" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>W4JSW1</accession>
    <name>W4JSW1_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Pyrimidine-specific carbamoyl phosphate synthase-aspartate carbamoyl transferase</fullName>
            <ecNumber evidence="6">2.1.3.2</ecNumber>
            <ecNumber evidence="5">3.5.1.2</ecNumber>
            <ecNumber evidence="20">6.3.4.16</ecNumber>
            <ecNumber evidence="4">6.3.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">HETIRDRAFT_53393</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31 32">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="25">Multifunctional protein that encodes the first 2 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5) and aspartate transcarbamylase (ATCase; EC 2.1.3.2). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="19">In the 2nd section; belongs to the CarB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the 3rd section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">In the C-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">In the N-terminal section; belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="6"/>
    <dbReference type="EC" id="3.5.1.2" evidence="5"/>
    <dbReference type="EC" id="6.3.4.16" evidence="20"/>
    <dbReference type="EC" id="6.3.5.5" evidence="4"/>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551182.1">
        <property type="nucleotide sequence ID" value="XM_009552887.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="W4JSW1">
        <property type="interactions" value="554"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JSW1"/>
    <dbReference type="GeneID" id="20678256"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_53393"/>
    <dbReference type="eggNOG" id="KOG0370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000513_2_1_1"/>
    <dbReference type="InParanoid" id="W4JSW1"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01423">
        <property type="entry name" value="MGS_CPS_I_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000002">
        <property type="entry name" value="Aspartate carbamoyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000025">
        <property type="entry name" value="Bifunctional pyrimidine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000005">
        <property type="entry name" value="CAD protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000005">
        <property type="entry name" value="CAD protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000011">
        <property type="entry name" value="CAD protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000004">
        <property type="entry name" value="Carbamoyl-phosphate synthase (glutamine-hydrolyzing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000036">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002032">
        <property type="entry name" value="PRK00856.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF5">
        <property type="entry name" value="CAD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00101">
        <property type="entry name" value="ATCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 27" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11 27" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="29">
        <location>
            <begin position="600"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="29">
        <location>
            <begin position="1140"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="30">
        <location>
            <begin position="1396"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00043968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00043979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00043984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00043998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00058513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00081752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="ETW76652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="2230" mass="244676" checksum="497797239D85E17E" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>W4JT17</accession>
    <name>W4JT17_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450 monooxygenase 66</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">cyp66</name>
        <name evidence="15" type="ORF">HETIRDRAFT_66435</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">TC 32-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925465">
        <property type="protein sequence ID" value="ETW76011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551890.1">
        <property type="nucleotide sequence ID" value="XM_009553595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JT17"/>
    <dbReference type="GeneID" id="20678777"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_66435"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_2_1_1"/>
    <dbReference type="InParanoid" id="W4JT17"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ETW76011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="529" mass="59659" checksum="EFC5F92CDBA16E31" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>W4JT42</accession>
    <name>W4JT42_HETIT</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription elongation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HETIRDRAFT_446561</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">TC 32-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TFS-II family.</text>
    </comment>
    <dbReference type="EMBL" id="KI925464">
        <property type="protein sequence ID" value="ETW76708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551586.1">
        <property type="nucleotide sequence ID" value="XM_009553291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JT42"/>
    <dbReference type="FunCoup" id="W4JT42">
        <property type="interactions" value="691"/>
    </dbReference>
    <dbReference type="STRING" id="747525.W4JT42"/>
    <dbReference type="GeneID" id="20675693"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_446561"/>
    <dbReference type="eggNOG" id="KOG1105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037637_1_0_1"/>
    <dbReference type="InParanoid" id="W4JT42"/>
    <dbReference type="OrthoDB" id="44867at2759"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001139">
        <property type="term" value="F:RNA polymerase II complex recruiting activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="IP08861P-RELATED"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="12">
        <location>
            <begin position="145"/>
            <end position="259"/>
        </location>
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        <location>
            <begin position="262"/>
            <end position="302"/>
        </location>
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            <begin position="76"/>
            <end position="142"/>
        </location>
    </feature>
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        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU368078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ETW76708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="304" mass="33236" checksum="746715D865793C6F" modified="2014-03-19" version="1">MTDALELRKLVKSLQHSSTDQEIVDLLNVLRKEAKITEALLRESKAGLAVGKLRQHASKEVSDLAKEVVRKWKQEVEKEKQAAGGSKANANGKSSASAPVPSRKSSVASVTPTTPTTPSGNSLANGSTRSSRSDGVNTNVTGDKTRDKCIELVYDALASDSGAPSDLILSRAKAVESAVLTEYKGTTAAYKTKIRQIFVNLKDKNNPGLRESVISGDLSAQKFAKMTSQEMASEERRAADQKIKDDNLFHSLGAEEQQAETDAFQCSRCKQRKCRYRQAQTRSADEPMTTFVTCTNCNNRWKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTP9</accession>
    <name>W4JTP9_HETIT</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HETIRDRAFT_481743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">TC 32-1</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="KEGG" id="hir:HETIRDRAFT_481743"/>
    <dbReference type="HOGENOM" id="CLU_2455011_0_0_1"/>
    <dbReference type="InParanoid" id="W4JTP9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ETW76261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="89" mass="10508" checksum="77537FF80A5A298C" modified="2014-03-19" version="1">MRLFSADLPVSFLAHLICPYLEFSSIKLECCRRWLVRPWKALLIGLVQIAEWPRIPSLMVYSVRRESVAEYNRTRFDQTGILCRSIHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>W4JTT0</accession>
    <name>W4JTT0_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HETIRDRAFT_442172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
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                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
            </authorList>
            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">TC 32-1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ETW76953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_009551811.1">
        <property type="nucleotide sequence ID" value="XM_009553516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W4JTT0"/>
    <dbReference type="GeneID" id="20675419"/>
    <dbReference type="KEGG" id="hir:HETIRDRAFT_442172"/>
    <dbReference type="HOGENOM" id="CLU_1570843_0_0_1"/>
    <dbReference type="InParanoid" id="W4JTT0"/>
    <dbReference type="Proteomes" id="UP000030671">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ETW76953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000030671"/>
        </source>
    </evidence>
    <sequence length="170" mass="18939" checksum="D3E44EFE4ED2E45A" modified="2014-03-19" version="1">MEKWMVHRAKHGGRLGRRRASARMCWSAREANLGFLSWCNRWRSSALGGGSAWHRGRECEQSRVRKSREGRADGRSSRSTHTRRNQGADKTSVWGFEAGMLREGTITGGTYRRTALPARRACVRHHRPVTTPSSLDSRCPSSASITIGSLFFSSACSTSRDKIIALLHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>W4JU07</accession>
    <name>W4JU07_HETIT</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HETIRDRAFT_455340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Heterobasidion irregulare (strain TC 32-1)</name>
        <dbReference type="NCBI Taxonomy" id="747525"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Russulales</taxon>
            <taxon>Bondarzewiaceae</taxon>
            <taxon>Heterobasidion</taxon>
            <taxon>Heterobasidion annosum species complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="New Phytol." volume="194" first="1001" last="1013">
            <title>Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen.</title>
            <authorList>
                <person name="Olson A."/>
                <person name="Aerts A."/>
                <person name="Asiegbu F."/>
                <person name="Belbahri L."/>
                <person name="Bouzid O."/>
                <person name="Broberg A."/>
                <person name="Canback B."/>
                <person name="Coutinho P.M."/>
                <person name="Cullen D."/>
                <person name="Dalman K."/>
                <person name="Deflorio G."/>
                <person name="van Diepen L.T."/>
                <person name="Dunand C."/>
                <person name="Duplessis S."/>
                <person name="Durling M."/>
                <person name="Gonthier P."/>
                <person name="Grimwood J."/>
                <person name="Fossdal C.G."/>
                <person name="Hansson D."/>
                <person name="Henrissat B."/>
                <person name="Hietala A."/>
                <person name="Himmelstrand K."/>
                <person name="Hoffmeister D."/>
                <person name="Hogberg N."/>
                <person name="James T.Y."/>
                <person name="Karlsson M."/>
                <person name="Kohler A."/>
                <person name="Kues U."/>
                <person name="Lee Y.H."/>
                <person name="Lin Y.C."/>
                <person name="Lind M."/>
                <person name="Lindquist E."/>
                <person name="Lombard V."/>
                <person name="Lucas S."/>
                <person name="Lunden K."/>
                <person name="Morin E."/>
                <person name="Murat C."/>
                <person name="Park J."/>
                <person name="Raffaello T."/>
                <person name="Rouze P."/>
                <person name="Salamov A."/>
                <person name="Schmutz J."/>
                <person name="Solheim H."/>
                <person name="Stahlberg J."/>
                <person name="Velez H."/>
                <person name="de Vries R.P."/>
                <person name="Wiebenga A."/>
                <person name="Woodward S."/>
                <person name="Yakovlev I."/>
                <person name="Garbelotto M."/>
                <person name="Martin F."/>
                <person name="Grigoriev I.V."/>
                <person name="Stenlid J."/>
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            <dbReference type="PubMed" id="22463738"/>
            <dbReference type="DOI" id="10.1111/j.1469-8137.2012.04128.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">TC 32-1</strain>
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        <property type="protein sequence ID" value="ETW76939.1"/>
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        <property type="term" value="F:RNA binding"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="2"/>
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    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="567"/>
            <end position="589"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="308"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="496"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
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    </feature>
    <feature type="compositionally biased